evidence_pass,evidence_status,failure_reasons,positive_evidence_inside,positive_evidence_reproductive,selectivity_gate_applied,selectivity_exclusions,rna_routine_missing,ihc_routine_missing,ihc_coverage,vital_rna_max_ntpm,protected_rna_max_ntpm,manageable_rna_max_ntpm,rna_exclusions,ihc_exclusions,ihc_forbidden_contexts_observed,absence_evidence,tissue_review_status,tissue_review_flags,tissue_review_contexts,Ensembl_Gene_ID,Symbol,scenario,retained,family_eligible,nomination_review_eligible,nomination_review_reason,source_dois,source_publications,manageable_worst_selectivity_margin,protected_worst_selectivity_margin,vital_worst_selectivity_margin
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,8.9,13,11.3,"parathyroid gland: 13 nTPM (protected, limit 2); thymus: 11.3 nTPM (manageable, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); retina: 5.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000000460,FIRRM,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 84.7458% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.0901% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.3396% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.3396% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.9101% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.9231% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.9091% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.3396% (minimum 99%, Baseline (adaptation disabled)); colon: 80.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.2857% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.7431% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.5926% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.4579% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.9091% (minimum 99%, Baseline (adaptation disabled)); liver: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 86.2069% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.7284% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.4579% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.7193% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 43.4783% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.9091% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.4286% (minimum 97%, Baseline (adaptation disabled)); retina: 65.3595% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 86.9565% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.7431% (minimum 99%, Baseline (adaptation disabled)); skin: 80.6452% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.7458% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 79.3651% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.4956% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.7402% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.7458% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.9484% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.2069% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.7193% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.5194% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,8.9,13,11.3,"parathyroid gland: 13 nTPM (protected, limit 2); thymus: 11.3 nTPM (manageable, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); retina: 5.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000000460,FIRRM,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.480516,-0.535217,-0.460899
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 84.7458% (minimum 95%, Missing); adrenal gland: 90.0901% (minimum 99%, Missing); amygdala: 94.3396% (minimum 99%, Missing); basal ganglia: 94.3396% (minimum 99%, Missing); bone marrow: 52.9101% (minimum 99%, Missing); cerebellum: 76.9231% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 99%, Missing); choroid plexus: 94.3396% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); duodenum: 89.2857% (minimum 99%, Uncertain); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 91.7431% (minimum 99%, Missing); hippocampal formation: 92.5926% (minimum 99%, Missing); hypothalamus: 93.4579% (minimum 99%, Missing); kidney: 90.9091% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lung: 86.2069% (minimum 99%, Missing); lymph node: 61.7284% (minimum 97%, Missing); midbrain: 93.4579% (minimum 99%, Missing); pancreas: 87.7193% (minimum 99%, Missing); parathyroid gland: 43.4783% (minimum 97%, Missing); pituitary gland: 90.9091% (minimum 99%, Missing); rectum: 71.4286% (minimum 97%, Uncertain); retina: 65.3595% (minimum 99%, Missing); salivary gland: 86.9565% (minimum 97%, Missing); skeletal muscle: 91.7431% (minimum 99%, Missing); skin: 80.6452% (minimum 95%, Missing); small intestine: 84.7458% (minimum 99%, Uncertain); smooth muscle: 79.3651% (minimum 99%, Missing); spinal cord: 88.4956% (minimum 99%, Missing); spleen: 78.7402% (minimum 95%, Missing); stomach: 84.7458% (minimum 97%, Missing); thymus: 46.9484% (minimum 95%, Missing); thyroid gland: 86.2069% (minimum 95%, Missing); tongue: 87.7193% (minimum 97%, Missing); urinary bladder: 77.5194% (minimum 97%, Missing)",0,0,routine_complete,8.9,13,11.3,"parathyroid gland: 13 nTPM (protected, limit 2); thymus: 11.3 nTPM (manageable, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); retina: 5.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000000460,FIRRM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.480516,-0.535217,-0.460899
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,12.4,15.8,12.6,"parathyroid gland: 15.8 nTPM (protected, limit 6); tongue: 13 nTPM (protected, limit 2); skeletal muscle: 12.4 nTPM (vital, limit 3); heart muscle: 12 nTPM (vital, limit 3); thymus: 10.7 nTPM (manageable, limit 5); cerebellum: 10.4 nTPM (vital, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 3); colon: 8.5 nTPM (protected, limit 2); adrenal gland: 8.4 nTPM (vital, limit 3); urinary bladder: 8.4 nTPM (protected, limit 6); liver: 8.1 nTPM (vital, limit 3); salivary gland: 8.1 nTPM (protected, limit 6); stomach: 7.9 nTPM (protected, limit 6); pancreas: 7.9 nTPM (vital, limit 3); esophagus: 7.7 nTPM (protected, limit 6); smooth muscle: 7.6 nTPM (vital, limit 3); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); spinal cord: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000001631,KRIT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.8235% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.9655% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.9341% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.5522% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.5714% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.4921% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.0391% (minimum 99%, Baseline (adaptation disabled)); colon: 58.5366% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.2983% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.9137% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.5714% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.9341% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.8720% (minimum 99%, Baseline (adaptation disabled)); liver: 59.7015% (minimum 99%, Baseline (adaptation disabled)); lung: 65.5738% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 67.7966% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.3015% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 43.1655% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.6038% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 74.5342% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.7015% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 49.1803% (minimum 99%, Baseline (adaptation disabled)); skin: 66.2983% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.8272% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.2245% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.5738% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.8298% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.3015% (minimum 97%, Baseline (adaptation disabled)); thymus: 52.8634% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.7805% (minimum 95%, Baseline (adaptation disabled)); tongue: 48.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.8235% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,12.4,15.8,12.6,"parathyroid gland: 15.8 nTPM (protected, limit 2); tongue: 13 nTPM (protected, limit 2); thyroid gland: 12.6 nTPM (manageable, limit 5); skeletal muscle: 12.4 nTPM (vital, limit 1); heart muscle: 12 nTPM (vital, limit 1); thymus: 10.7 nTPM (manageable, limit 5); cerebellum: 10.4 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 2); urinary bladder: 8.4 nTPM (protected, limit 2); adrenal gland: 8.4 nTPM (vital, limit 1); salivary gland: 8.1 nTPM (protected, limit 2); liver: 8.1 nTPM (vital, limit 1); adipose tissue: 8 nTPM (manageable, limit 5); stomach: 7.9 nTPM (protected, limit 2); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 2); smooth muscle: 7.6 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); lung: 6.3 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); lymph node: 6 nTPM (protected, limit 2); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000001631,KRIT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.462195,-0.538345,-0.498197
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.0000% (minimum 80%, Supported); adrenal gland: 58.8235% (minimum 97%, Supported); amygdala: 68.9655% (minimum 99%, Missing); basal ganglia: 65.9341% (minimum 99%, Missing); bone marrow: 89.5522% (minimum 97%, Supported); cerebellum: 53.5714% (minimum 97%, Supported); cerebral cortex: 63.4921% (minimum 97%, Supported); choroid plexus: 67.0391% (minimum 99%, Missing); colon: 58.5366% (minimum 97%, Missing); duodenum: 66.2983% (minimum 99%, Missing); esophagus: 60.9137% (minimum 90%, Supported); heart muscle: 50.0000% (minimum 97%, Supported); hippocampal formation: 68.5714% (minimum 99%, Missing); hypothalamus: 65.9341% (minimum 99%, Missing); kidney: 56.8720% (minimum 97%, Supported); liver: 59.7015% (minimum 97%, Supported); lung: 65.5738% (minimum 97%, Supported); lymph node: 66.6667% (minimum 90%, Supported); midbrain: 67.7966% (minimum 99%, Missing); pancreas: 60.3015% (minimum 97%, Supported); parathyroid gland: 43.1655% (minimum 90%, Supported); pituitary gland: 56.6038% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 74.5342% (minimum 99%, Missing); salivary gland: 59.7015% (minimum 90%, Supported); skeletal muscle: 49.1803% (minimum 97%, Supported); skin: 66.2983% (minimum 80%, Supported); small intestine: 62.8272% (minimum 99%, Missing); smooth muscle: 61.2245% (minimum 97%, Supported); spinal cord: 65.5738% (minimum 99%, Missing); spleen: 63.8298% (minimum 80%, Supported); stomach: 60.3015% (minimum 90%, Supported); thymus: 52.8634% (minimum 95%, Missing); thyroid gland: 48.7805% (minimum 80%, Supported); tongue: 48.0000% (minimum 97%, Missing); urinary bladder: 58.8235% (minimum 90%, Supported)",0,6,partial,12.4,15.8,12.6,"parathyroid gland: 15.8 nTPM (protected, limit 6); tongue: 13 nTPM (protected, limit 2); skeletal muscle: 12.4 nTPM (vital, limit 3); heart muscle: 12 nTPM (vital, limit 3); thymus: 10.7 nTPM (manageable, limit 5); cerebellum: 10.4 nTPM (vital, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 3); colon: 8.5 nTPM (protected, limit 2); adrenal gland: 8.4 nTPM (vital, limit 3); urinary bladder: 8.4 nTPM (protected, limit 6); liver: 8.1 nTPM (vital, limit 3); salivary gland: 8.1 nTPM (protected, limit 6); stomach: 7.9 nTPM (protected, limit 6); pancreas: 7.9 nTPM (vital, limit 3); esophagus: 7.7 nTPM (protected, limit 6); smooth muscle: 7.6 nTPM (vital, limit 3); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); spinal cord: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000001631,KRIT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.421366,-0.49,-0.478197
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,20.2,3.7,1.2,"bone marrow: 20.2 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000004809,SLC22A16,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 50.7317% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5782% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.8980% (minimum 97%, Baseline (adaptation disabled)); smooth muscle: 92.4444% (minimum 99%, Baseline (adaptation disabled)); thymus: 94.5455% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,20.2,3.7,1.2,"bone marrow: 20.2 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000004809,SLC22A16,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,-0.00454545,-0.12102,-0.482683
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 50.7317% (minimum 99%, Missing); lung: 98.5782% (minimum 99%, Missing); parathyroid gland: 84.8980% (minimum 97%, Missing); smooth muscle: 92.4444% (minimum 99%, Uncertain); thymus: 94.5455% (minimum 95%, Missing)",0,1,partial,20.2,3.7,1.2,"bone marrow: 20.2 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000004809,SLC22A16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,-0.00454545,-0.12102,-0.482683
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,82.5,3.6,1.8,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000004838,ZMYND10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7441% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.3338% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.2846% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.8401% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.8794% (minimum 99%, Baseline (adaptation disabled)); lung: 95.8794% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.7441% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7814% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,82.5,3.6,1.8,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000004838,ZMYND10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0428882,0.0158768,-0.237154
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7441% (minimum 99%, Missing); basal ganglia: 95.3338% (minimum 99%, Missing); choroid plexus: 75.2846% (minimum 99%, Missing); hippocampal formation: 96.8401% (minimum 99%, Missing); hypothalamus: 95.8794% (minimum 99%, Missing); lung: 95.8794% (minimum 99%, Missing); pituitary gland: 97.7441% (minimum 99%, Missing); retina: 98.7814% (minimum 99%, Missing)",0,80,unavailable,82.5,3.6,1.8,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000004838,ZMYND10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0428882,0.0158768,-0.237154
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,22,28.9,22.9,"lymph node: 28.9 nTPM (protected, limit 2); thymus: 22.9 nTPM (manageable, limit 5); tongue: 22.7 nTPM (protected, limit 2); skeletal muscle: 22 nTPM (vital, limit 1); spleen: 16.9 nTPM (manageable, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 2); urinary bladder: 16.3 nTPM (protected, limit 2); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 2); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); skin: 10.9 nTPM (manageable, limit 5); stomach: 10.8 nTPM (protected, limit 2); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 2); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000005175,RPAP3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.7736% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.1324% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.9149% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 57.2881% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.5039% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.0756% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.0156% (minimum 99%, Baseline (adaptation disabled)); colon: 58.2759% (minimum 97%, Baseline (adaptation disabled)); duodenum: 55.7756% (minimum 99%, Baseline (adaptation disabled)); esophagus: 56.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.1602% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.5354% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.4830% (minimum 99%, Baseline (adaptation disabled)); liver: 52.9781% (minimum 99%, Baseline (adaptation disabled)); lung: 63.0597% (minimum 99%, Baseline (adaptation disabled)); lymph node: 36.8996% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.9149% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.0635% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.2976% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.8715% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.6792% (minimum 97%, Baseline (adaptation disabled)); retina: 61.0108% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.0152% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 43.4447% (minimum 99%, Baseline (adaptation disabled)); skin: 60.7914% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.8767% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.3123% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.6992% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.0108% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.4623% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.7756% (minimum 95%, Baseline (adaptation disabled)); tongue: 42.6768% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.9036% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,22,28.9,22.9,"lymph node: 28.9 nTPM (protected, limit 2); thymus: 22.9 nTPM (manageable, limit 5); tongue: 22.7 nTPM (protected, limit 2); skeletal muscle: 22 nTPM (vital, limit 1); spleen: 16.9 nTPM (manageable, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 2); urinary bladder: 16.3 nTPM (protected, limit 2); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 2); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); skin: 10.9 nTPM (manageable, limit 5); stomach: 10.8 nTPM (protected, limit 2); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 2); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000005175,RPAP3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.525377,-0.601004,-0.555553
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.7736% (minimum 95%, Missing); adrenal gland: 62.1324% (minimum 99%, Missing); amygdala: 72.2222% (minimum 99%, Missing); basal ganglia: 71.9149% (minimum 99%, Missing); bone marrow: 57.2881% (minimum 99%, Missing); cerebellum: 65.5039% (minimum 99%, Missing); cerebral cortex: 58.0756% (minimum 99%, Missing); choroid plexus: 66.0156% (minimum 99%, Missing); colon: 58.2759% (minimum 97%, Missing); duodenum: 55.7756% (minimum 99%, Missing); esophagus: 56.3333% (minimum 97%, Missing); heart muscle: 52.0000% (minimum 99%, Missing); hippocampal formation: 73.1602% (minimum 99%, Missing); hypothalamus: 66.5354% (minimum 99%, Missing); kidney: 57.4830% (minimum 99%, Missing); liver: 52.9781% (minimum 99%, Missing); lung: 63.0597% (minimum 99%, Missing); lymph node: 36.8996% (minimum 97%, Missing); midbrain: 71.9149% (minimum 99%, Missing); pancreas: 67.0635% (minimum 99%, Missing); parathyroid gland: 50.2976% (minimum 97%, Missing); pituitary gland: 67.8715% (minimum 99%, Missing); rectum: 57.6792% (minimum 97%, Missing); retina: 61.0108% (minimum 99%, Missing); salivary gland: 64.0152% (minimum 97%, Missing); skeletal muscle: 43.4447% (minimum 99%, Missing); skin: 60.7914% (minimum 95%, Missing); small intestine: 57.8767% (minimum 99%, Missing); smooth muscle: 53.3123% (minimum 99%, Missing); spinal cord: 68.6992% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 61.0108% (minimum 97%, Missing); thymus: 42.4623% (minimum 95%, Missing); thyroid gland: 55.7756% (minimum 95%, Missing); tongue: 42.6768% (minimum 97%, Missing); urinary bladder: 50.9036% (minimum 97%, Missing)",0,3,partial,22,28.9,22.9,"lymph node: 28.9 nTPM (protected, limit 2); thymus: 22.9 nTPM (manageable, limit 5); tongue: 22.7 nTPM (protected, limit 2); skeletal muscle: 22 nTPM (vital, limit 1); spleen: 16.9 nTPM (manageable, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 2); urinary bladder: 16.3 nTPM (protected, limit 2); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 2); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); skin: 10.9 nTPM (manageable, limit 5); stomach: 10.8 nTPM (protected, limit 2); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 2); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000005175,RPAP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.525377,-0.601004,-0.555553
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,11.4,38.6,7.2,"parathyroid gland: 38.6 nTPM (protected, limit 4); bone marrow: 11.4 nTPM (vital, limit 2); thymus: 7.2 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 2); rectum: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 2); cerebellum: 2.5 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000005189,REXO5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 96.6985% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.6376% (minimum 97%, Baseline (adaptation disabled)); retina: 98.7870% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,11.4,38.6,7.2,"parathyroid gland: 38.6 nTPM (protected, limit 2); bone marrow: 11.4 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000005189,REXO5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0288918,-0.0736242,-0.0230148
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 96.6985% (minimum 98%, Approved); parathyroid gland: 89.6376% (minimum 95%, Approved); retina: 98.7870% (minimum 99%, Missing)",0,2,partial,11.4,38.6,7.2,"parathyroid gland: 38.6 nTPM (protected, limit 4); bone marrow: 11.4 nTPM (vital, limit 2); thymus: 7.2 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 2); rectum: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 2); cerebellum: 2.5 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000005189,REXO5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0288918,-0.0536242,-0.0130148
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,29.2,14.9,16.8,"bone marrow: 29.2 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); parathyroid gland: 14.9 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); tongue: 12 nTPM (protected, limit 2); spleen: 12 nTPM (manageable, limit 5); lymph node: 11.3 nTPM (protected, limit 2); thyroid gland: 10.4 nTPM (manageable, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); urinary bladder: 8.8 nTPM (protected, limit 2); heart muscle: 8.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); cerebral cortex: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000005889,ZFX,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 54.3165% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.5853% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.8794% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.2626% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 34.0858% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.6364% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.2661% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.7487% (minimum 99%, Baseline (adaptation disabled)); colon: 61.3821% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.5853% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.6364% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.9831% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.2626% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.2383% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.2281% (minimum 99%, Baseline (adaptation disabled)); liver: 60.6426% (minimum 99%, Baseline (adaptation disabled)); lung: 64.5299% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.1970% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.8794% (minimum 99%, Baseline (adaptation disabled)); pancreas: 61.1336% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.9048% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.9048% (minimum 97%, Baseline (adaptation disabled)); retina: 60.4000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 67.7130% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.8418% (minimum 99%, Baseline (adaptation disabled)); skin: 65.9389% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.6522% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 51.8900% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.6585% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.7196% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.2281% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.3354% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.2157% (minimum 95%, Baseline (adaptation disabled)); tongue: 55.7196% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.1799% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,29.2,14.9,16.8,"bone marrow: 29.2 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); parathyroid gland: 14.9 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); tongue: 12 nTPM (protected, limit 2); spleen: 12 nTPM (manageable, limit 5); lymph node: 11.3 nTPM (protected, limit 2); thyroid gland: 10.4 nTPM (manageable, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); urinary bladder: 8.8 nTPM (protected, limit 2); heart muscle: 8.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); cerebral cortex: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000005889,ZFX,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.476646,-0.466667,-0.649142
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 54.3165% (minimum 95%, Missing); adrenal gland: 69.5853% (minimum 99%, Missing); amygdala: 75.8794% (minimum 99%, Missing); basal ganglia: 76.2626% (minimum 99%, Missing); bone marrow: 34.0858% (minimum 99%, Missing); cerebellum: 68.6364% (minimum 99%, Missing); cerebral cortex: 69.2661% (minimum 99%, Missing); choroid plexus: 80.7487% (minimum 99%, Missing); colon: 61.3821% (minimum 97%, Missing); duodenum: 69.5853% (minimum 99%, Missing); esophagus: 68.6364% (minimum 97%, Missing); heart muscle: 63.9831% (minimum 99%, Missing); hippocampal formation: 76.2626% (minimum 99%, Missing); hypothalamus: 78.2383% (minimum 99%, Missing); kidney: 66.2281% (minimum 99%, Missing); liver: 60.6426% (minimum 99%, Missing); lung: 64.5299% (minimum 99%, Missing); lymph node: 57.1970% (minimum 97%, Missing); midbrain: 75.8794% (minimum 99%, Missing); pancreas: 61.1336% (minimum 99%, Missing); parathyroid gland: 50.3333% (minimum 97%, Missing); pituitary gland: 71.9048% (minimum 99%, Missing); rectum: 71.9048% (minimum 97%, Missing); retina: 60.4000% (minimum 99%, Missing); salivary gland: 67.7130% (minimum 97%, Missing); skeletal muscle: 50.8418% (minimum 99%, Missing); skin: 65.9389% (minimum 95%, Missing); small intestine: 65.6522% (minimum 99%, Missing); smooth muscle: 51.8900% (minimum 99%, Missing); spinal cord: 73.6585% (minimum 99%, Missing); spleen: 55.7196% (minimum 95%, Missing); stomach: 66.2281% (minimum 97%, Missing); thymus: 47.3354% (minimum 95%, Missing); thyroid gland: 59.2157% (minimum 95%, Missing); tongue: 55.7196% (minimum 97%, Missing); urinary bladder: 63.1799% (minimum 97%, Missing)",0,4,partial,29.2,14.9,16.8,"bone marrow: 29.2 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); parathyroid gland: 14.9 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); tongue: 12 nTPM (protected, limit 2); spleen: 12 nTPM (manageable, limit 5); lymph node: 11.3 nTPM (protected, limit 2); thyroid gland: 10.4 nTPM (manageable, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); urinary bladder: 8.8 nTPM (protected, limit 2); heart muscle: 8.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); cerebral cortex: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000005889,ZFX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.476646,-0.466667,-0.649142
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,3.9,7,2.9,"hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000006047,YBX2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,3.9,7,2.9,"colon: 7 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000006047,YBX2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0446167,0.0171039,0.00277376
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,3.9,7,2.9,"hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000006047,YBX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0298134,0.00646643
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,6,partial,0,0.9,46,"skin: 46 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,ENSG00000006059,KRT33A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); esophagus: 72.7273% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 82.7586% (minimum 97%, Baseline (adaptation disabled)); skin: 4.9587% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,0,0.9,46,"skin: 46 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,ENSG00000006059,KRT33A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.900413,-0.242727,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 80%, Supported); esophagus: 72.7273% (minimum 90%, Supported); salivary gland: 82.7586% (minimum 90%, Supported); skin: 4.9587% (minimum 95%, Missing)",0,6,partial,0,0.9,46,"skin: 46 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,ENSG00000006059,KRT33A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.900413,-0.172727,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,16.2,12.7,7.3,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); rectum: 9 nTPM (protected, limit 2); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 2); duodenum: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 2); esophagus: 6.7 nTPM (protected, limit 2); thymus: 6.5 nTPM (manageable, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 4.9 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000006459,KDM7A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3548% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.4159% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.4615% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.4615% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 36.2205% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.9661% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.0159% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.9293% (minimum 99%, Baseline (adaptation disabled)); colon: 53.1792% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.4884% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.8616% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.2290% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.7925% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.3204% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.4409% (minimum 99%, Baseline (adaptation disabled)); liver: 58.5987% (minimum 99%, Baseline (adaptation disabled)); lung: 66.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.6190% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.6471% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.6970% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.4615% (minimum 99%, Baseline (adaptation disabled)); rectum: 50.5495% (minimum 97%, Baseline (adaptation disabled)); retina: 61.7450% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.2482% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 42.9907% (minimum 99%, Baseline (adaptation disabled)); skin: 55.7576% (minimum 95%, Baseline (adaptation disabled)); small intestine: 53.1792% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.6567% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.1429% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.0137% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.2732% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.5987% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 77.3109% (minimum 95%, Baseline (adaptation disabled)); tongue: 42.0091% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.5850% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,16.2,12.7,7.3,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); rectum: 9 nTPM (protected, limit 2); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 2); duodenum: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 2); esophagus: 6.7 nTPM (protected, limit 2); thymus: 6.5 nTPM (manageable, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 4.9 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000006459,KDM7A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.392424,-0.549909,-0.627795
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3548% (minimum 95%, Missing); adrenal gland: 81.4159% (minimum 99%, Missing); amygdala: 88.4615% (minimum 99%, Missing); basal ganglia: 88.4615% (minimum 99%, Missing); bone marrow: 36.2205% (minimum 99%, Missing); cerebellum: 77.9661% (minimum 99%, Missing); cerebral cortex: 73.0159% (minimum 99%, Missing); choroid plexus: 92.9293% (minimum 99%, Missing); colon: 53.1792% (minimum 97%, Missing); duodenum: 53.4884% (minimum 99%, Missing); esophagus: 57.8616% (minimum 97%, Missing); heart muscle: 70.2290% (minimum 99%, Uncertain); hippocampal formation: 86.7925% (minimum 99%, Missing); hypothalamus: 89.3204% (minimum 99%, Missing); kidney: 72.4409% (minimum 99%, Missing); liver: 58.5987% (minimum 99%, Missing); lung: 66.6667% (minimum 99%, Missing); lymph node: 57.5000% (minimum 97%, Missing); midbrain: 87.6190% (minimum 99%, Missing); pancreas: 67.6471% (minimum 99%, Missing); parathyroid gland: 69.6970% (minimum 97%, Missing); pituitary gland: 88.4615% (minimum 99%, Missing); rectum: 50.5495% (minimum 97%, Missing); retina: 61.7450% (minimum 99%, Missing); salivary gland: 65.2482% (minimum 97%, Missing); skeletal muscle: 42.9907% (minimum 99%, Missing); skin: 55.7576% (minimum 95%, Missing); small intestine: 53.1792% (minimum 99%, Missing); smooth muscle: 68.6567% (minimum 99%, Missing); spinal cord: 82.1429% (minimum 99%, Missing); spleen: 63.0137% (minimum 95%, Missing); stomach: 50.2732% (minimum 97%, Missing); thymus: 58.5987% (minimum 95%, Missing); thyroid gland: 77.3109% (minimum 95%, Missing); tongue: 42.0091% (minimum 97%, Missing); urinary bladder: 62.5850% (minimum 97%, Missing)",0,1,partial,16.2,12.7,7.3,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); rectum: 9 nTPM (protected, limit 2); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 2); duodenum: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 2); esophagus: 6.7 nTPM (protected, limit 2); thymus: 6.5 nTPM (manageable, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 4.9 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000006459,KDM7A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.392424,-0.549909,-0.627795
True,compatible,,True,True,False,,0,80,unavailable,0.6,0.5,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000006634,DBF4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.6577% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.0784% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6577% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.6577% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.6577% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.6577% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6577% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.7105% (minimum 97%, Baseline (adaptation disabled)); retina: 98.6577% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.5,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000006634,DBF4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0107843,-0.00289474,-0.0292157
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.6577% (minimum 99%, Missing); basal ganglia: 98.0000% (minimum 99%, Missing); bone marrow: 96.0784% (minimum 99%, Missing); cerebellum: 98.0000% (minimum 99%, Missing); cerebral cortex: 98.6577% (minimum 99%, Missing); duodenum: 98.6577% (minimum 99%, Missing); hippocampal formation: 98.6577% (minimum 99%, Missing); hypothalamus: 98.6577% (minimum 99%, Missing); kidney: 98.6577% (minimum 99%, Missing); lymph node: 96.7105% (minimum 97%, Missing); retina: 98.6577% (minimum 99%, Missing); small intestine: 98.0000% (minimum 99%, Missing)",0,80,unavailable,0.6,0.5,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000006634,DBF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0107843,-0.00289474,-0.0292157
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.4,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000006659,LGALS14,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,,True,True,True,,0,80,unavailable,0.5,0.4,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000006659,LGALS14,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0360248,0.0237402,0.0021875
True,compatible,,True,True,True,,0,80,unavailable,0.5,0.4,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000006659,LGALS14,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0360248,0.0237402,0.0021875
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.2,3.1,1.1,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000006837,CDKL3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.5294% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.6543% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6111% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.0256% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.5422% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.8734% (minimum 99%, Baseline (adaptation disabled)); colon: 94.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.9310% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.9459% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.5422% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.5238% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.0237% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.4459% (minimum 99%, Baseline (adaptation disabled)); liver: 95.3020% (minimum 99%, Baseline (adaptation disabled)); lung: 96.5986% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.3020% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.5581% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.5986% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.0397% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.9459% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.9459% (minimum 97%, Baseline (adaptation disabled)); retina: 77.1739% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 82.0809% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.9459% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.0256% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.0409% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.5986% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.0397% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.8105% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.0809% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.9459% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.2,3.1,1.1,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000006837,CDKL3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0218954,-0.149191,-0.218261
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.6667% (minimum 99%, Missing); amygdala: 83.5294% (minimum 99%, Missing); basal ganglia: 87.6543% (minimum 99%, Missing); bone marrow: 98.6111% (minimum 99%, Missing); cerebellum: 91.0256% (minimum 99%, Missing); cerebral cortex: 85.5422% (minimum 99%, Missing); choroid plexus: 89.8734% (minimum 99%, Missing); colon: 94.6667% (minimum 97%, Missing); duodenum: 97.9310% (minimum 99%, Missing); esophagus: 95.9459% (minimum 97%, Missing); heart muscle: 85.5422% (minimum 99%, Missing); hippocampal formation: 84.5238% (minimum 99%, Missing); hypothalamus: 84.0237% (minimum 99%, Missing); kidney: 90.4459% (minimum 99%, Missing); liver: 95.3020% (minimum 99%, Missing); lung: 96.5986% (minimum 99%, Missing); lymph node: 95.3020% (minimum 97%, Missing); midbrain: 82.5581% (minimum 99%, Missing); pancreas: 96.5986% (minimum 99%, Missing); parathyroid gland: 94.0397% (minimum 97%, Missing); pituitary gland: 95.9459% (minimum 99%, Missing); rectum: 95.9459% (minimum 97%, Missing); retina: 77.1739% (minimum 99%, Missing); skeletal muscle: 82.0809% (minimum 99%, Missing); small intestine: 95.9459% (minimum 99%, Missing); smooth muscle: 91.0256% (minimum 99%, Missing); spinal cord: 83.0409% (minimum 99%, Missing); stomach: 96.5986% (minimum 97%, Missing); thymus: 94.0397% (minimum 95%, Missing); thyroid gland: 92.8105% (minimum 95%, Missing); tongue: 82.0809% (minimum 97%, Missing); urinary bladder: 95.9459% (minimum 97%, Missing)",0,80,unavailable,4.2,3.1,1.1,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000006837,CDKL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0218954,-0.149191,-0.218261
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,7.7,19.9,1.7,"salivary gland: 19.9 nTPM (protected, limit 12); bone marrow: 7.7 nTPM (vital, limit 6); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000007038,PRSS21,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 91.4444% (minimum 99%, Baseline (adaptation disabled)); lung: 97.1665% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.6275% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.5284% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,7.7,19.9,1.7,"salivary gland: 19.9 nTPM (protected, limit 2); bone marrow: 7.7 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000007038,PRSS21,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,0.0297619,-0.164716,-0.0755556
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 91.4444% (minimum 95%, Enhanced); lung: 97.1665% (minimum 99%, Missing); pancreas: 97.6275% (minimum 99%, Missing)",0,5,partial,7.7,19.9,1.7,"salivary gland: 19.9 nTPM (protected, limit 12); bone marrow: 7.7 nTPM (vital, limit 6); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000007038,PRSS21,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,0.0368106,0.00528376,-0.0355556
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,13,3.5,2,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000007174,DNAH9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.4598% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.7077% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.9976% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.0469% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.4286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.4637% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.6501% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.3992% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.7807% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.5182% (minimum 99%, Baseline (adaptation disabled)); lung: 92.6630% (minimum 99%, Baseline (adaptation disabled)); midbrain: 88.8021% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.9861% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.6915% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 84.1975% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5549% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.4209% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,13,3.5,2,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000007174,DNAH9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.00540166,-0.0630851,-0.266008
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 80.9976% (minimum 99%, Missing); basal ganglia: 80.0469% (minimum 99%, Missing); cerebral cortex: 85.4637% (minimum 95%, Enhanced); choroid plexus: 73.6501% (minimum 99%, Missing); hippocampal formation: 72.3992% (minimum 99%, Missing); hypothalamus: 74.7807% (minimum 99%, Missing); lung: 92.6630% (minimum 95%, Enhanced); midbrain: 88.8021% (minimum 99%, Missing); pancreas: 94.9861% (minimum 95%, Enhanced); pituitary gland: 91.6667% (minimum 99%, Missing); retina: 84.1975% (minimum 99%, Missing); spinal cord: 91.4209% (minimum 99%, Missing)",0,4,partial,13,3.5,2,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000007174,DNAH9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.047076,0.027076,-0.266008
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,3.7,0.5,0.7,"retina: 2.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000007350,TKTL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 97.0889% (minimum 99%, Baseline (adaptation disabled)); retina: 98.3267% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,3.7,0.5,0.7,"heart muscle: 3.7 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000007350,TKTL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0443594,0.0259645,-0.0191109
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.3267% (minimum 99%, Missing)",0,2,partial,3.7,0.5,0.7,"retina: 2.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000007350,TKTL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.046769,0.0259645,-0.00673307
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,27.6,19,27.9,"adipose tissue: 27.9 nTPM (manageable, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (manageable, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); skin: 20.9 nTPM (manageable, limit 5); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 2); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 2); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 2); stomach: 13.5 nTPM (protected, limit 2); urinary bladder: 13.4 nTPM (protected, limit 2); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); parathyroid gland: 11.1 nTPM (protected, limit 2); spleen: 10.7 nTPM (manageable, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); thymus: 5.6 nTPM (manageable, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000008256,CYTH3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.3891% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.9424% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.4000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.3665% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.0202% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.8154% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.7143% (minimum 99%, Baseline (adaptation disabled)); colon: 63.5611% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.7388% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.3002% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.6587% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.4584% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.0611% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.9888% (minimum 99%, Baseline (adaptation disabled)); liver: 88.4726% (minimum 99%, Baseline (adaptation disabled)); lung: 61.6466% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.5153% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.0913% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.7895% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.4450% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.1787% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.0856% (minimum 97%, Baseline (adaptation disabled)); retina: 84.8066% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.7488% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 67.7704% (minimum 99%, Baseline (adaptation disabled)); skin: 59.4961% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.4584% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.5768% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.4324% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.1546% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.4570% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.5730% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.2986% (minimum 95%, Baseline (adaptation disabled)); tongue: 61.7706% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.6145% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,27.6,19,27.9,"adipose tissue: 27.9 nTPM (manageable, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (manageable, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); skin: 20.9 nTPM (manageable, limit 5); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 2); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 2); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 2); stomach: 13.5 nTPM (protected, limit 2); urinary bladder: 13.4 nTPM (protected, limit 2); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); parathyroid gland: 11.1 nTPM (protected, limit 2); spleen: 10.7 nTPM (manageable, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); thymus: 5.6 nTPM (manageable, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000008256,CYTH3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.426109,-0.352294,-0.463413
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.3891% (minimum 95%, Missing); adrenal gland: 76.9424% (minimum 99%, Missing); amygdala: 68.2222% (minimum 99%, Missing); basal ganglia: 61.4000% (minimum 99%, Missing); bone marrow: 80.3665% (minimum 99%, Missing); cerebellum: 62.0202% (minimum 99%, Missing); cerebral cortex: 57.8154% (minimum 99%, Missing); choroid plexus: 87.7143% (minimum 99%, Missing); colon: 63.5611% (minimum 97%, Missing); duodenum: 65.7388% (minimum 99%, Uncertain); esophagus: 69.3002% (minimum 97%, Uncertain); heart muscle: 52.6587% (minimum 99%, Missing); hippocampal formation: 65.4584% (minimum 99%, Missing); hypothalamus: 75.0611% (minimum 99%, Missing); kidney: 68.9888% (minimum 99%, Missing); liver: 88.4726% (minimum 99%, Uncertain); lung: 61.6466% (minimum 99%, Missing); lymph node: 85.5153% (minimum 97%, Missing); midbrain: 70.0913% (minimum 99%, Missing); pancreas: 80.7895% (minimum 99%, Uncertain); parathyroid gland: 73.4450% (minimum 97%, Missing); pituitary gland: 76.1787% (minimum 99%, Missing); rectum: 82.0856% (minimum 97%, Uncertain); retina: 84.8066% (minimum 99%, Missing); salivary gland: 72.7488% (minimum 97%, Uncertain); skeletal muscle: 67.7704% (minimum 99%, Missing); skin: 59.4961% (minimum 95%, Missing); small intestine: 65.4584% (minimum 99%, Uncertain); smooth muscle: 72.5768% (minimum 99%, Missing); spinal cord: 81.4324% (minimum 99%, Missing); spleen: 74.1546% (minimum 95%, Uncertain); stomach: 69.4570% (minimum 97%, Missing); thymus: 84.5730% (minimum 95%, Missing); thyroid gland: 53.2986% (minimum 95%, Missing); tongue: 61.7706% (minimum 97%, Missing); urinary bladder: 69.6145% (minimum 97%, Uncertain)",0,5,partial,27.6,19,27.9,"adipose tissue: 27.9 nTPM (manageable, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (manageable, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); skin: 20.9 nTPM (manageable, limit 5); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 2); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 2); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 2); stomach: 13.5 nTPM (protected, limit 2); urinary bladder: 13.4 nTPM (protected, limit 2); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); parathyroid gland: 11.1 nTPM (protected, limit 2); spleen: 10.7 nTPM (manageable, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); thymus: 5.6 nTPM (manageable, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000008256,CYTH3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.426109,-0.352294,-0.463413
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,63.3,56.3,24.8,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 2); parathyroid gland: 35 nTPM (protected, limit 2); smooth muscle: 28.1 nTPM (vital, limit 2); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 2); urinary bladder: 27.1 nTPM (protected, limit 2); adipose tissue: 24.8 nTPM (manageable, limit 5); rectum: 22.5 nTPM (protected, limit 2); liver: 22.3 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 2); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 2); lymph node: 20.5 nTPM (protected, limit 4); stomach: 20.4 nTPM (protected, limit 2); small intestine: 20.3 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); thymus: 18.1 nTPM (manageable, limit 5); spleen: 17.5 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (manageable, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000009335,UBE3C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6958% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.2837% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.8333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.2338% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.4458% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.0470% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.0048% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.7216% (minimum 99%, Baseline (adaptation disabled)); colon: 54.1401% (minimum 97%, Baseline (adaptation disabled)); duodenum: 56.7929% (minimum 99%, Baseline (adaptation disabled)); esophagus: 48.2955% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 48.1132% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.0549% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.2291% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.5410% (minimum 99%, Baseline (adaptation disabled)); liver: 53.3473% (minimum 99%, Baseline (adaptation disabled)); lung: 58.0866% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.4348% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.0549% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.0254% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 42.1488% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.2479% (minimum 99%, Baseline (adaptation disabled)); rectum: 53.1250% (minimum 97%, Baseline (adaptation disabled)); retina: 56.5410% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.5714% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 28.7162% (minimum 99%, Baseline (adaptation disabled)); skin: 55.7987% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.6769% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 47.5746% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.7539% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.3023% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.5556% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.4862% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.2837% (minimum 95%, Baseline (adaptation disabled)); tongue: 31.1736% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 48.4791% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,63.3,56.3,24.8,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 2); parathyroid gland: 35 nTPM (protected, limit 2); smooth muscle: 28.1 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 2); urinary bladder: 27.1 nTPM (protected, limit 2); adipose tissue: 24.8 nTPM (manageable, limit 5); rectum: 22.5 nTPM (protected, limit 2); liver: 22.3 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 2); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 2); lymph node: 20.5 nTPM (protected, limit 2); stomach: 20.4 nTPM (protected, limit 2); small intestine: 20.3 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); thymus: 18.1 nTPM (manageable, limit 5); spleen: 17.5 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (manageable, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000009335,UBE3C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.443042,-0.658264,-0.702838
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6958% (minimum 95%, Missing); adrenal gland: 60.2837% (minimum 99%, Missing); amygdala: 70.8333% (minimum 99%, Missing); basal ganglia: 66.2338% (minimum 99%, Missing); bone marrow: 61.4458% (minimum 99%, Missing); cerebellum: 57.0470% (minimum 99%, Missing); cerebral cortex: 61.0048% (minimum 99%, Missing); choroid plexus: 65.7216% (minimum 99%, Missing); colon: 54.1401% (minimum 97%, Missing); duodenum: 56.7929% (minimum 99%, Missing); esophagus: 48.2955% (minimum 97%, Missing); heart muscle: 48.1132% (minimum 99%, Missing); hippocampal formation: 70.0549% (minimum 99%, Missing); hypothalamus: 71.2291% (minimum 99%, Missing); kidney: 56.5410% (minimum 99%, Missing); liver: 53.3473% (minimum 99%, Missing); lung: 58.0866% (minimum 99%, Missing); lymph node: 55.4348% (minimum 95%, Approved); midbrain: 70.0549% (minimum 99%, Missing); pancreas: 54.0254% (minimum 99%, Missing); parathyroid gland: 42.1488% (minimum 97%, Missing); pituitary gland: 70.2479% (minimum 99%, Missing); rectum: 53.1250% (minimum 97%, Missing); retina: 56.5410% (minimum 99%, Missing); salivary gland: 53.5714% (minimum 97%, Missing); skeletal muscle: 28.7162% (minimum 99%, Missing); skin: 55.7987% (minimum 95%, Missing); small intestine: 55.6769% (minimum 99%, Missing); smooth muscle: 47.5746% (minimum 98%, Approved); spinal cord: 66.7539% (minimum 99%, Missing); spleen: 59.3023% (minimum 95%, Missing); stomach: 55.5556% (minimum 97%, Missing); thymus: 58.4862% (minimum 95%, Missing); thyroid gland: 60.2837% (minimum 95%, Missing); tongue: 31.1736% (minimum 97%, Missing); urinary bladder: 48.4791% (minimum 97%, Missing)",0,7,partial,63.3,56.3,24.8,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 2); parathyroid gland: 35 nTPM (protected, limit 2); smooth muscle: 28.1 nTPM (vital, limit 2); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 2); urinary bladder: 27.1 nTPM (protected, limit 2); adipose tissue: 24.8 nTPM (manageable, limit 5); rectum: 22.5 nTPM (protected, limit 2); liver: 22.3 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 2); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 2); lymph node: 20.5 nTPM (protected, limit 4); stomach: 20.4 nTPM (protected, limit 2); small intestine: 20.3 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); thymus: 18.1 nTPM (manageable, limit 5); spleen: 17.5 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (manageable, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000009335,UBE3C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.443042,-0.658264,-0.702838
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,11.7,6.2,7,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); thymus: 7 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 2); skin: 5.7 nTPM (manageable, limit 5); esophagus: 5.5 nTPM (protected, limit 2); tongue: 5.1 nTPM (protected, limit 2); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); urinary bladder: 4.6 nTPM (protected, limit 2); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000010072,SPRTN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.0492% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.1136% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.9398% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.9398% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.6512% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 87.0370% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.2162% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.0370% (minimum 99%, Baseline (adaptation disabled)); colon: 79.6610% (minimum 97%, Baseline (adaptation disabled)); duodenum: 78.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.9388% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.6304% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.4320% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.9286% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.2162% (minimum 99%, Baseline (adaptation disabled)); liver: 73.8220% (minimum 99%, Baseline (adaptation disabled)); lung: 79.6610% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.4581% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.9412% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.4311% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.4011% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.9286% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.2135% (minimum 97%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.5714% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.2287% (minimum 99%, Baseline (adaptation disabled)); skin: 71.2121% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.1136% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.9006% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.2105% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.9006% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.8246% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 74.2105% (minimum 95%, Baseline (adaptation disabled)); tongue: 73.4375% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.4011% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,11.7,6.2,7,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); thymus: 7 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 2); skin: 5.7 nTPM (manageable, limit 5); esophagus: 5.5 nTPM (protected, limit 2); tongue: 5.1 nTPM (protected, limit 2); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); urinary bladder: 4.6 nTPM (protected, limit 2); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000010072,SPRTN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.281754,-0.275419,-0.443488
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.0492% (minimum 95%, Uncertain); adrenal gland: 80.1136% (minimum 99%, Missing); amygdala: 84.9398% (minimum 99%, Missing); basal ganglia: 84.9398% (minimum 99%, Missing); bone marrow: 54.6512% (minimum 99%, Missing); cerebellum: 87.0370% (minimum 99%, Missing); cerebral cortex: 76.2162% (minimum 99%, Missing); choroid plexus: 87.0370% (minimum 99%, Missing); colon: 79.6610% (minimum 97%, Missing); duodenum: 78.3333% (minimum 99%, Uncertain); esophagus: 71.9388% (minimum 97%, Uncertain); heart muscle: 76.6304% (minimum 99%, Uncertain); hippocampal formation: 83.4320% (minimum 99%, Missing); hypothalamus: 83.9286% (minimum 99%, Missing); kidney: 76.2162% (minimum 99%, Uncertain); liver: 73.8220% (minimum 99%, Uncertain); lung: 79.6610% (minimum 99%, Uncertain); lymph node: 69.4581% (minimum 97%, Missing); midbrain: 82.9412% (minimum 99%, Missing); pancreas: 84.4311% (minimum 99%, Uncertain); parathyroid gland: 75.4011% (minimum 97%, Uncertain); pituitary gland: 83.9286% (minimum 99%, Missing); rectum: 79.2135% (minimum 97%, Uncertain); retina: 75.0000% (minimum 99%, Missing); salivary gland: 80.5714% (minimum 97%, Uncertain); skeletal muscle: 63.2287% (minimum 99%, Uncertain); skin: 71.2121% (minimum 95%, Missing); small intestine: 80.1136% (minimum 99%, Uncertain); smooth muscle: 75.0000% (minimum 99%, Uncertain); spinal cord: 77.9006% (minimum 99%, Missing); spleen: 74.2105% (minimum 95%, Uncertain); stomach: 77.9006% (minimum 97%, Uncertain); thymus: 66.8246% (minimum 95%, Missing); thyroid gland: 74.2105% (minimum 95%, Missing); tongue: 73.4375% (minimum 97%, Missing); urinary bladder: 75.4011% (minimum 97%, Uncertain)",0,0,routine_complete,11.7,6.2,7,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); thymus: 7 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 2); skin: 5.7 nTPM (manageable, limit 5); esophagus: 5.5 nTPM (protected, limit 2); tongue: 5.1 nTPM (protected, limit 2); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); urinary bladder: 4.6 nTPM (protected, limit 2); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000010072,SPRTN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.281754,-0.275419,-0.443488
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,4.6,5.5,4.9,"choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000010318,PHF7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,2,partial,4.6,5.5,4.9,"parathyroid gland: 5.5 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); rectum: 4.4 nTPM (protected, limit 2); colon: 4.2 nTPM (protected, limit 2); pancreas: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); urinary bladder: 2.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000010318,PHF7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0458692,0.0253657,0.00612109
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,2,partial,4.6,5.5,4.9,"choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000010318,PHF7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0476353,0.0292387,0.00771959
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,1.6,3.3,2.6,"lymph node: 3.3 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000011590,ZBTB32,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 98.7578% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.5294% (minimum 97%, Baseline (adaptation disabled)); small intestine: 96.7546% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.8310% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,1.6,3.3,2.6,"lymph node: 3.3 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000011590,ZBTB32,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00168986,-0.0347059,-0.0224544
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 98.7578% (minimum 99%, Missing); lymph node: 93.5294% (minimum 97%, Missing); spleen: 94.8310% (minimum 95%, Missing)",0,6,partial,1.6,3.3,2.6,"lymph node: 3.3 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000011590,ZBTB32,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00168986,-0.0347059,-0.00242236
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,28.8,12.9,23.4,"bone marrow: 28.8 nTPM (vital, limit 1); thymus: 23.4 nTPM (manageable, limit 5); pancreas: 17 nTPM (vital, limit 1); skin: 16.3 nTPM (manageable, limit 5); spleen: 13.5 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 2); skeletal muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); stomach: 9.3 nTPM (protected, limit 2); colon: 9.3 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 3); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 2); thyroid gland: 7.8 nTPM (manageable, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 2); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000013573,DDX11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.2439% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.3136% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.1022% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.6765% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 27.0886% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.8718% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.2877% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.4805% (minimum 99%, Baseline (adaptation disabled)); colon: 53.5000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.1522% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.7215% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.9784% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.5362% (minimum 99%, Baseline (adaptation disabled)); kidney: 54.3147% (minimum 99%, Baseline (adaptation disabled)); liver: 54.0404% (minimum 99%, Baseline (adaptation disabled)); lung: 64.4578% (minimum 99%, Baseline (adaptation disabled)); lymph node: 45.3390% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.4286% (minimum 99%, Baseline (adaptation disabled)); pancreas: 38.6282% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.6442% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 53.7688% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.4510% (minimum 97%, Baseline (adaptation disabled)); retina: 62.5731% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.3158% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.9524% (minimum 99%, Baseline (adaptation disabled)); skin: 39.6296% (minimum 95%, Baseline (adaptation disabled)); small intestine: 45.1477% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.8865% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.8865% (minimum 99%, Baseline (adaptation disabled)); spleen: 44.2149% (minimum 95%, Baseline (adaptation disabled)); stomach: 53.5000% (minimum 97%, Baseline (adaptation disabled)); thymus: 31.3783% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.8378% (minimum 95%, Baseline (adaptation disabled)); tongue: 63.3136% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.4943% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,28.8,12.9,23.4,"bone marrow: 28.8 nTPM (vital, limit 1); thymus: 23.4 nTPM (manageable, limit 5); pancreas: 17 nTPM (vital, limit 1); skin: 16.3 nTPM (manageable, limit 5); spleen: 13.5 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 2); skeletal muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); colon: 9.3 nTPM (protected, limit 2); stomach: 9.3 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 2); thyroid gland: 7.8 nTPM (manageable, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 2); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); parathyroid gland: 5.6 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000013573,DDX11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.636217,-0.51661,-0.719114
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.2439% (minimum 95%, Missing); adrenal gland: 63.3136% (minimum 99%, Missing); amygdala: 78.1022% (minimum 99%, Missing); basal ganglia: 78.6765% (minimum 99%, Missing); bone marrow: 27.0886% (minimum 99%, Missing); cerebellum: 54.8718% (minimum 99%, Missing); cerebral cortex: 73.2877% (minimum 99%, Missing); choroid plexus: 69.4805% (minimum 99%, Missing); colon: 53.5000% (minimum 97%, Missing); duodenum: 58.1522% (minimum 99%, Missing); esophagus: 53.5000% (minimum 97%, Missing); heart muscle: 67.7215% (minimum 99%, Missing); hippocampal formation: 76.9784% (minimum 99%, Missing); hypothalamus: 77.5362% (minimum 99%, Missing); kidney: 54.3147% (minimum 99%, Missing); liver: 54.0404% (minimum 97%, Supported); lung: 64.4578% (minimum 99%, Missing); lymph node: 45.3390% (minimum 97%, Missing); midbrain: 76.4286% (minimum 99%, Missing); pancreas: 38.6282% (minimum 99%, Missing); parathyroid gland: 65.6442% (minimum 90%, Supported); pituitary gland: 53.7688% (minimum 99%, Missing); rectum: 52.4510% (minimum 97%, Missing); retina: 62.5731% (minimum 99%, Missing); salivary gland: 56.3158% (minimum 97%, Missing); skeletal muscle: 50.9524% (minimum 99%, Missing); skin: 39.6296% (minimum 95%, Missing); small intestine: 45.1477% (minimum 99%, Missing); smooth muscle: 75.8865% (minimum 99%, Missing); spinal cord: 75.8865% (minimum 99%, Missing); spleen: 44.2149% (minimum 95%, Missing); stomach: 53.5000% (minimum 97%, Missing); thymus: 31.3783% (minimum 95%, Missing); thyroid gland: 57.8378% (minimum 95%, Missing); tongue: 63.3136% (minimum 97%, Missing); urinary bladder: 61.4943% (minimum 97%, Missing)",0,7,partial,28.8,12.9,23.4,"bone marrow: 28.8 nTPM (vital, limit 1); thymus: 23.4 nTPM (manageable, limit 5); pancreas: 17 nTPM (vital, limit 1); skin: 16.3 nTPM (manageable, limit 5); spleen: 13.5 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 2); skeletal muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); stomach: 9.3 nTPM (protected, limit 2); colon: 9.3 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 3); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 2); thyroid gland: 7.8 nTPM (manageable, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 2); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000013573,DDX11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.636217,-0.51661,-0.719114
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,55.5,39,50.2,"bone marrow: 55.5 nTPM (vital, limit 1); thymus: 50.2 nTPM (manageable, limit 5); lymph node: 39 nTPM (protected, limit 2); spleen: 21.5 nTPM (manageable, limit 5); esophagus: 14.4 nTPM (protected, limit 2); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 6); duodenum: 5.9 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 2); urinary bladder: 4.3 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 2 / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / extracellular matrix; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000013810,TACC3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.7757% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.8166% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.8442% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2277% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 46.9407% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.2418% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.7115% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.4670% (minimum 99%, Baseline (adaptation disabled)); colon: 83.6457% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.2727% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.3228% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.8815% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.6535% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.6535% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.9710% (minimum 99%, Baseline (adaptation disabled)); liver: 93.5238% (minimum 99%, Baseline (adaptation disabled)); lung: 88.6282% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.7321% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.4637% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.6143% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.0861% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.1550% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.9392% (minimum 97%, Baseline (adaptation disabled)); retina: 96.6535% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.1689% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.8442% (minimum 99%, Baseline (adaptation disabled)); skin: 90.0917% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.7078% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.1107% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.4637% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.5467% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.7579% (minimum 97%, Baseline (adaptation disabled)); thymus: 49.4461% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.8815% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 91.9476% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,55.5,39,50.2,"bone marrow: 55.5 nTPM (vital, limit 1); thymus: 50.2 nTPM (manageable, limit 5); lymph node: 39 nTPM (protected, limit 2); spleen: 21.5 nTPM (manageable, limit 5); esophagus: 14.4 nTPM (protected, limit 2); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 2); urinary bladder: 4.3 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); liver: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 2 / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / extracellular matrix; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000013810,TACC3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.455539,-0.412679,-0.520593
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.8166% (minimum 95%, Enhanced); amygdala: 96.8442% (minimum 99%, Missing); basal ganglia: 97.2277% (minimum 99%, Missing); bone marrow: 46.9407% (minimum 99%, Missing); cerebellum: 94.2418% (minimum 95%, Enhanced); cerebral cortex: 95.7115% (minimum 99%, Missing); choroid plexus: 92.4670% (minimum 99%, Missing); colon: 83.6457% (minimum 97%, Missing); duodenum: 89.2727% (minimum 99%, Missing); esophagus: 77.3228% (minimum 97%, Missing); heart muscle: 93.8815% (minimum 95%, Enhanced); hippocampal formation: 96.6535% (minimum 99%, Missing); hypothalamus: 96.6535% (minimum 99%, Missing); kidney: 94.9710% (minimum 99%, Missing); liver: 93.5238% (minimum 95%, Enhanced); lung: 88.6282% (minimum 95%, Enhanced); lymph node: 55.7321% (minimum 97%, Missing); midbrain: 96.4637% (minimum 99%, Missing); pituitary gland: 95.1550% (minimum 99%, Missing); rectum: 82.9392% (minimum 97%, Missing); retina: 96.6535% (minimum 99%, Missing); salivary gland: 93.1689% (minimum 97%, Missing); skeletal muscle: 96.8442% (minimum 99%, Missing); skin: 90.0917% (minimum 95%, Missing); small intestine: 79.7078% (minimum 99%, Missing); smooth muscle: 89.1107% (minimum 95%, Enhanced); spinal cord: 96.4637% (minimum 99%, Missing); spleen: 69.5467% (minimum 95%, Missing); stomach: 90.7579% (minimum 97%, Missing); thymus: 49.4461% (minimum 95%, Missing); tongue: 93.8815% (minimum 97%, Missing); urinary bladder: 91.9476% (minimum 97%, Missing)",0,6,partial,55.5,39,50.2,"bone marrow: 55.5 nTPM (vital, limit 1); thymus: 50.2 nTPM (manageable, limit 5); lymph node: 39 nTPM (protected, limit 2); spleen: 21.5 nTPM (manageable, limit 5); esophagus: 14.4 nTPM (protected, limit 2); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 6); duodenum: 5.9 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 2); urinary bladder: 4.3 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 2 / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / extracellular matrix; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000013810,TACC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.455539,-0.412679,-0.520593
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.3,6.9,10.7,"skin: 10.7 nTPM (manageable, limit 5); thymus: 7.1 nTPM (manageable, limit 5); parathyroid gland: 6.9 nTPM (protected, limit 2); esophagus: 6.8 nTPM (protected, limit 2); thyroid gland: 6.6 nTPM (manageable, limit 5); lymph node: 6.4 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); stomach: 5.7 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5.4 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000020256,ZFP64,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7168% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.5042% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.8649% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.6087% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.0164% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.0169% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 54.5455% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.9245% (minimum 99%, Baseline (adaptation disabled)); colon: 54.5455% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 51.4286% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.0169% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.8649% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.8649% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.0169% (minimum 99%, Baseline (adaptation disabled)); liver: 58.5366% (minimum 99%, Baseline (adaptation disabled)); lung: 62.6087% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.9412% (minimum 97%, Baseline (adaptation disabled)); midbrain: 65.4545% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.6929% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.0638% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.5385% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.1429% (minimum 97%, Baseline (adaptation disabled)); retina: 60.5042% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.2500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 59.0164% (minimum 99%, Baseline (adaptation disabled)); skin: 40.2235% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.2500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.6000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.0550% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.1429% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.8140% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.3497% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.1739% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.6087% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.3,6.9,10.7,"skin: 10.7 nTPM (manageable, limit 5); thymus: 7.1 nTPM (manageable, limit 5); parathyroid gland: 6.9 nTPM (protected, limit 2); esophagus: 6.8 nTPM (protected, limit 2); thyroid gland: 6.6 nTPM (manageable, limit 5); lymph node: 6.4 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); stomach: 5.7 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5.4 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000020256,ZFP64,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.547765,-0.459362,-0.456667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7168% (minimum 95%, Missing); adrenal gland: 60.5042% (minimum 99%, Missing); amygdala: 64.8649% (minimum 99%, Missing); basal ganglia: 62.6087% (minimum 99%, Missing); bone marrow: 59.0164% (minimum 99%, Missing); cerebellum: 61.0169% (minimum 99%, Missing); cerebral cortex: 54.5455% (minimum 99%, Missing); choroid plexus: 67.9245% (minimum 99%, Missing); colon: 54.5455% (minimum 97%, Missing); duodenum: 53.3333% (minimum 99%, Missing); esophagus: 51.4286% (minimum 97%, Missing); heart muscle: 61.0169% (minimum 99%, Missing); hippocampal formation: 64.8649% (minimum 99%, Missing); hypothalamus: 64.8649% (minimum 99%, Missing); kidney: 61.0169% (minimum 99%, Missing); liver: 58.5366% (minimum 99%, Missing); lung: 62.6087% (minimum 99%, Missing); lymph node: 52.9412% (minimum 97%, Missing); midbrain: 65.4545% (minimum 99%, Missing); pancreas: 56.6929% (minimum 99%, Missing); parathyroid gland: 51.0638% (minimum 97%, Missing); pituitary gland: 61.5385% (minimum 99%, Missing); rectum: 57.1429% (minimum 97%, Missing); retina: 60.5042% (minimum 99%, Missing); salivary gland: 56.2500% (minimum 97%, Missing); skeletal muscle: 59.0164% (minimum 99%, Missing); skin: 40.2235% (minimum 95%, Missing); small intestine: 56.2500% (minimum 99%, Missing); smooth muscle: 57.6000% (minimum 99%, Missing); spinal cord: 66.0550% (minimum 99%, Missing); spleen: 57.1429% (minimum 95%, Missing); stomach: 55.8140% (minimum 97%, Missing); thymus: 50.3497% (minimum 95%, Missing); thyroid gland: 52.1739% (minimum 95%, Missing); tongue: 62.6087% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",0,80,unavailable,6.3,6.9,10.7,"skin: 10.7 nTPM (manageable, limit 5); thymus: 7.1 nTPM (manageable, limit 5); parathyroid gland: 6.9 nTPM (protected, limit 2); esophagus: 6.8 nTPM (protected, limit 2); thyroid gland: 6.6 nTPM (manageable, limit 5); lymph node: 6.4 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); stomach: 5.7 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5.4 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000020256,ZFP64,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.547765,-0.459362,-0.456667
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,13,9.7,13.7,"thymus: 13.7 nTPM (manageable, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 2); tongue: 9.6 nTPM (protected, limit 2); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 2); basal ganglia: 7.1 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 2); esophagus: 6.9 nTPM (protected, limit 2); spleen: 6.9 nTPM (manageable, limit 5); stomach: 6.3 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 2); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 5.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000021574,SPAST,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2258% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.8205% (minimum 99%, Baseline (adaptation disabled)); amygdala: 55.3672% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 57.9882% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.2462% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.3672% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 42.9825% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.2174% (minimum 99%, Baseline (adaptation disabled)); colon: 58.6826% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.3099% (minimum 99%, Baseline (adaptation disabled)); esophagus: 58.6826% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.5328% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 52.6882% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 54.7486% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.2258% (minimum 99%, Baseline (adaptation disabled)); liver: 51.3089% (minimum 99%, Baseline (adaptation disabled)); lung: 61.6352% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.2564% (minimum 97%, Baseline (adaptation disabled)); midbrain: 51.3089% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.9007% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.0253% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.3099% (minimum 97%, Baseline (adaptation disabled)); retina: 57.9882% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 56.3218% (minimum 99%, Baseline (adaptation disabled)); skin: 57.6471% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.3672% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.9882% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 43.7500% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.6826% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.8696% (minimum 97%, Baseline (adaptation disabled)); thymus: 41.7021% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.5519% (minimum 95%, Baseline (adaptation disabled)); tongue: 50.5155% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.6471% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,13,9.7,13.7,"thymus: 13.7 nTPM (manageable, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 2); tongue: 9.6 nTPM (protected, limit 2); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 2); basal ganglia: 7.1 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 2); esophagus: 6.9 nTPM (protected, limit 2); spleen: 6.9 nTPM (manageable, limit 5); stomach: 6.3 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 2); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 5.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000021574,SPAST,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.532979,-0.467436,-0.560175
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2258% (minimum 95%, Missing); adrenal gland: 62.8205% (minimum 99%, Missing); amygdala: 55.3672% (minimum 99%, Missing); basal ganglia: 57.9882% (minimum 99%, Missing); bone marrow: 49.2462% (minimum 99%, Missing); cerebellum: 55.3672% (minimum 99%, Missing); cerebral cortex: 42.9825% (minimum 99%, Missing); choroid plexus: 85.2174% (minimum 99%, Missing); colon: 58.6826% (minimum 97%, Missing); duodenum: 57.3099% (minimum 99%, Missing); esophagus: 58.6826% (minimum 97%, Missing); heart muscle: 71.5328% (minimum 99%, Missing); hippocampal formation: 52.6882% (minimum 99%, Missing); hypothalamus: 54.7486% (minimum 99%, Missing); kidney: 63.2258% (minimum 99%, Missing); liver: 51.3089% (minimum 99%, Missing); lung: 61.6352% (minimum 99%, Missing); lymph node: 50.2564% (minimum 97%, Missing); midbrain: 51.3089% (minimum 99%, Missing); pancreas: 64.9007% (minimum 99%, Missing); parathyroid gland: 62.0253% (minimum 97%, Missing); pituitary gland: 70.0000% (minimum 99%, Missing); rectum: 57.3099% (minimum 97%, Missing); retina: 57.9882% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 56.3218% (minimum 99%, Missing); skin: 57.6471% (minimum 95%, Missing); small intestine: 55.3672% (minimum 99%, Missing); smooth muscle: 57.9882% (minimum 99%, Missing); spinal cord: 43.7500% (minimum 99%, Missing); spleen: 58.6826% (minimum 95%, Missing); stomach: 60.8696% (minimum 97%, Missing); thymus: 41.7021% (minimum 95%, Missing); thyroid gland: 53.5519% (minimum 95%, Missing); tongue: 50.5155% (minimum 97%, Missing); urinary bladder: 57.6471% (minimum 97%, Missing)",0,3,partial,13,9.7,13.7,"thymus: 13.7 nTPM (manageable, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 2); tongue: 9.6 nTPM (protected, limit 2); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 2); basal ganglia: 7.1 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 2); esophagus: 6.9 nTPM (protected, limit 2); spleen: 6.9 nTPM (manageable, limit 5); stomach: 6.3 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 2); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 5.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000021574,SPAST,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.532979,-0.467436,-0.560175
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,4.9,4.7,7.9,"thymus: 7.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 2); lymph node: 4.7 nTPM (protected, limit 4); rectum: 3.4 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000024526,DEPDC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 98.7342% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.4173% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 73.5849% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.4706% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.2277% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.7342% (minimum 99%, Baseline (adaptation disabled)); liver: 95.1220% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.4000% (minimum 97%, Baseline (adaptation disabled)); rectum: 69.6429% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.2963% (minimum 97%, Baseline (adaptation disabled)); skin: 83.8710% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.2277% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.7826% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.9759% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 49.6815% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 89.6552% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,4.9,4.7,7.9,"thymus: 7.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000024526,DEPDC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.453185,-0.346,-0.375827
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4173% (minimum 98%, Approved); cerebral cortex: 97.5000% (minimum 99%, Missing); colon: 73.5849% (minimum 97%, Missing); duodenum: 76.4706% (minimum 99%, Missing); esophagus: 77.2277% (minimum 97%, Missing); liver: 95.1220% (minimum 98%, Approved); lung: 97.5000% (minimum 98%, Approved); lymph node: 62.4000% (minimum 95%, Approved); rectum: 69.6429% (minimum 97%, Missing); skin: 83.8710% (minimum 95%, Missing); small intestine: 77.2277% (minimum 99%, Missing); smooth muscle: 84.7826% (minimum 99%, Missing); spleen: 93.9759% (minimum 95%, Missing); stomach: 86.6667% (minimum 97%, Missing); thymus: 49.6815% (minimum 95%, Missing); urinary bladder: 89.6552% (minimum 97%, Missing)",0,6,partial,4.9,4.7,7.9,"thymus: 7.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 2); lymph node: 4.7 nTPM (protected, limit 4); rectum: 3.4 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000024526,DEPDC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.453185,-0.326,-0.365827
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,5,partial,46.8,61.7,17.4,"tongue: 61.7 nTPM (protected, limit 2); skeletal muscle: 46.8 nTPM (vital, limit 2); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 2); heart muscle: 22.4 nTPM (vital, limit 2); cerebellum: 17.9 nTPM (vital, limit 2); thymus: 17.4 nTPM (manageable, limit 5); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 2); parathyroid gland: 13.6 nTPM (protected, limit 4); smooth muscle: 13.5 nTPM (vital, limit 2); skin: 12.4 nTPM (manageable, limit 10); lymph node: 12.4 nTPM (protected, limit 4); cerebral cortex: 11.5 nTPM (vital, limit 2); colon: 11.2 nTPM (protected, limit 4); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 4); stomach: 9.1 nTPM (protected, limit 4); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 2); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.4 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 4); esophagus: 8 nTPM (protected, limit 4); duodenum: 6.7 nTPM (vital, limit 2); rectum: 6.7 nTPM (protected, limit 4); kidney: 6.5 nTPM (vital, limit 2); pancreas: 6.2 nTPM (vital, limit 2); liver: 5.3 nTPM (vital, limit 2)",,64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000025156,HSF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.4563% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.2362% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.8791% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.7576% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.2761% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.1905% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.5652% (minimum 99%, Baseline (adaptation disabled)); colon: 76.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.5977% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.1429% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.1622% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.5252% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.8267% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.9885% (minimum 99%, Baseline (adaptation disabled)); liver: 87.4109% (minimum 99%, Baseline (adaptation disabled)); lung: 81.2362% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.7967% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.4159% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.5814% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.0159% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.1316% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.5977% (minimum 97%, Baseline (adaptation disabled)); retina: 46.0576% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 81.7778% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 44.0191% (minimum 99%, Baseline (adaptation disabled)); skin: 74.7967% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.7018% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.1610% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.0573% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.3493% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.1743% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.8967% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.0573% (minimum 95%, Baseline (adaptation disabled)); tongue: 37.3604% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 79.8265% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,46.8,61.7,17.4,"tongue: 61.7 nTPM (protected, limit 2); skeletal muscle: 46.8 nTPM (vital, limit 1); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); heart muscle: 22.4 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 2); smooth muscle: 13.5 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 2); skin: 12.4 nTPM (manageable, limit 5); cerebral cortex: 11.5 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 2); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); stomach: 9.1 nTPM (protected, limit 2); spleen: 9 nTPM (manageable, limit 5); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); thyroid gland: 8.6 nTPM (manageable, limit 5); amygdala: 8.5 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); midbrain: 8.4 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 2); esophagus: 8 nTPM (protected, limit 2); duodenum: 6.7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); kidney: 6.5 nTPM (vital, limit 1); pancreas: 6.2 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1)",,64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000025156,HSF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.271033,-0.596396,-0.549809
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 90%, Approved); adrenal gland: 71.4563% (minimum 98%, Approved); amygdala: 81.2362% (minimum 99%, Missing); basal ganglia: 80.8791% (minimum 99%, Missing); bone marrow: 55.7576% (minimum 98%, Approved); cerebellum: 67.2761% (minimum 98%, Approved); cerebral cortex: 76.1905% (minimum 98%, Approved); choroid plexus: 69.5652% (minimum 99%, Missing); colon: 76.6667% (minimum 95%, Approved); duodenum: 84.5977% (minimum 98%, Approved); esophagus: 82.1429% (minimum 95%, Approved); heart muscle: 62.1622% (minimum 98%, Approved); hippocampal formation: 80.5252% (minimum 99%, Missing); hypothalamus: 76.8267% (minimum 99%, Missing); kidney: 84.9885% (minimum 98%, Approved); liver: 87.4109% (minimum 98%, Approved); lung: 81.2362% (minimum 98%, Approved); lymph node: 74.7967% (minimum 95%, Approved); midbrain: 81.4159% (minimum 99%, Missing); pancreas: 85.5814% (minimum 98%, Approved); parathyroid gland: 73.0159% (minimum 95%, Approved); pituitary gland: 78.1316% (minimum 99%, Missing); rectum: 84.5977% (minimum 95%, Approved); retina: 46.0576% (minimum 99%, Missing); salivary gland: 81.7778% (minimum 95%, Approved); skeletal muscle: 44.0191% (minimum 98%, Approved); skin: 74.7967% (minimum 90%, Approved); small intestine: 80.7018% (minimum 98%, Approved); smooth muscle: 73.1610% (minimum 98%, Approved); spinal cord: 81.0573% (minimum 99%, Missing); spleen: 80.3493% (minimum 90%, Approved); stomach: 80.1743% (minimum 95%, Approved); thymus: 67.8967% (minimum 95%, Missing); thyroid gland: 81.0573% (minimum 90%, Approved); tongue: 37.3604% (minimum 97%, Missing); urinary bladder: 79.8265% (minimum 95%, Approved)",0,5,partial,46.8,61.7,17.4,"tongue: 61.7 nTPM (protected, limit 2); skeletal muscle: 46.8 nTPM (vital, limit 2); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 2); heart muscle: 22.4 nTPM (vital, limit 2); cerebellum: 17.9 nTPM (vital, limit 2); thymus: 17.4 nTPM (manageable, limit 5); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 2); parathyroid gland: 13.6 nTPM (protected, limit 4); smooth muscle: 13.5 nTPM (vital, limit 2); skin: 12.4 nTPM (manageable, limit 10); lymph node: 12.4 nTPM (protected, limit 4); cerebral cortex: 11.5 nTPM (vital, limit 2); colon: 11.2 nTPM (protected, limit 4); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 4); stomach: 9.1 nTPM (protected, limit 4); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 2); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.4 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 4); esophagus: 8 nTPM (protected, limit 4); duodenum: 6.7 nTPM (vital, limit 2); rectum: 6.7 nTPM (protected, limit 4); kidney: 6.5 nTPM (vital, limit 2); pancreas: 6.2 nTPM (vital, limit 2); liver: 5.3 nTPM (vital, limit 2)",,64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000025156,HSF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.271033,-0.596396,-0.539809
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.7,1.7,0.5,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,ENSG00000027644,INSRR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.1667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 59.3750% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.3636% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.0769% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.4762% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 95.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.4762% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.1667% (minimum 99%, Baseline (adaptation disabled)); kidney: 33.9286% (minimum 99%, Baseline (adaptation disabled)); midbrain: 86.3636% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.4762% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 79.1667% (minimum 99%, Baseline (adaptation disabled)); retina: 90.4762% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); stomach: 52.7778% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.3636% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.7,1.7,0.5,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,ENSG00000027644,INSRR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.158333,-0.442222,-0.650714
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.1667% (minimum 95%, Missing); adrenal gland: 59.3750% (minimum 99%, Missing); basal ganglia: 86.3636% (minimum 99%, Missing); cerebellum: 73.0769% (minimum 99%, Missing); cerebral cortex: 90.4762% (minimum 99%, Missing); choroid plexus: 95.0000% (minimum 99%, Missing); colon: 95.0000% (minimum 97%, Missing); heart muscle: 90.4762% (minimum 99%, Missing); hypothalamus: 79.1667% (minimum 99%, Missing); kidney: 33.9286% (minimum 99%, Missing); midbrain: 86.3636% (minimum 99%, Missing); pancreas: 90.4762% (minimum 99%, Missing); pituitary gland: 79.1667% (minimum 99%, Missing); retina: 90.4762% (minimum 99%, Missing); salivary gland: 95.0000% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); stomach: 52.7778% (minimum 97%, Missing); thymus: 86.3636% (minimum 95%, Missing)",0,80,unavailable,3.7,1.7,0.5,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,ENSG00000027644,INSRR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.158333,-0.442222,-0.650714
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,11,8.8,20.2,"thymus: 20.2 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 2); colon: 3.9 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); spinal cord: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000035499,DEPDC1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Jamin 2021;Bruggeman 2018;Bradley 2020,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.4000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.4000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.4000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.7897% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.4000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.8931% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.6190% (minimum 99%, Baseline (adaptation disabled)); colon: 75.9259% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.5824% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.6735% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 97.6190% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.6190% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.4570% (minimum 99%, Baseline (adaptation disabled)); liver: 97.6190% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6190% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.2938% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.0938% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.4915% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.0938% (minimum 97%, Baseline (adaptation disabled)); skin: 86.0140% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.4865% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.8931% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.4892% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.1304% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.4412% (minimum 97%, Baseline (adaptation disabled)); thymus: 37.8462% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.1111% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.4812% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,11,8.8,20.2,"thymus: 20.2 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 2); colon: 3.9 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); spinal cord: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000035499,DEPDC1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Jamin 2021;Bruggeman 2018;Bradley 2020,-0.571538,-0.387062,-0.462103
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.4000% (minimum 99%, Missing); basal ganglia: 98.4000% (minimum 99%, Missing); bone marrow: 52.7897% (minimum 99%, Missing); cerebral cortex: 93.8931% (minimum 99%, Missing); choroid plexus: 97.6190% (minimum 99%, Missing); colon: 75.9259% (minimum 97%, Missing); duodenum: 67.5824% (minimum 99%, Missing); esophagus: 83.6735% (minimum 97%, Missing); hippocampal formation: 97.6190% (minimum 99%, Missing); hypothalamus: 97.6190% (minimum 99%, Missing); kidney: 81.4570% (minimum 99%, Missing); liver: 97.6190% (minimum 98%, Approved); lung: 97.6190% (minimum 99%, Missing); lymph node: 58.2938% (minimum 97%, Missing); midbrain: 96.0938% (minimum 99%, Missing); rectum: 69.4915% (minimum 97%, Missing); skin: 86.0140% (minimum 90%, Approved); small intestine: 66.4865% (minimum 99%, Missing); smooth muscle: 93.8931% (minimum 99%, Missing); spinal cord: 88.4892% (minimum 99%, Missing); spleen: 89.1304% (minimum 95%, Missing); stomach: 90.4412% (minimum 95%, Approved); thymus: 37.8462% (minimum 95%, Missing); thyroid gland: 91.1111% (minimum 95%, Missing); urinary bladder: 92.4812% (minimum 97%, Missing)",0,2,partial,11,8.8,20.2,"thymus: 20.2 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 2); colon: 3.9 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); spinal cord: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000035499,DEPDC1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Jamin 2021;Bruggeman 2018;Bradley 2020,-0.571538,-0.387062,-0.462103
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,11,partial,8.9,39.8,15.7,"lymph node: 39.8 nTPM (protected, limit 2); spleen: 15.7 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); bone marrow: 5.8 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000035720,STAP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.0968% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.4286% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 31.7647% (minimum 99%, Baseline (adaptation disabled)); colon: 54.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.3636% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.4118% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.1034% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.4118% (minimum 99%, Baseline (adaptation disabled)); kidney: 23.2759% (minimum 99%, Baseline (adaptation disabled)); liver: 90.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 65.8537% (minimum 99%, Baseline (adaptation disabled)); lymph node: 6.3529% (minimum 97%, Baseline (adaptation disabled)); pancreas: 90.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 55.1020% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 67.5000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.4286% (minimum 99%, Baseline (adaptation disabled)); small intestine: 25.4717% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.0968% (minimum 99%, Baseline (adaptation disabled)); spleen: 14.6739% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.1020% (minimum 97%, Baseline (adaptation disabled)); thymus: 30.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.0968% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 61.3636% (minimum 97%, Baseline (adaptation disabled))",0,11,partial,8.9,39.8,15.7,"lymph node: 39.8 nTPM (protected, limit 2); spleen: 15.7 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); bone marrow: 5.8 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000035720,STAP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.803261,-0.906471,-0.757241
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 31.7647% (minimum 99%, Missing); colon: 54.0000% (minimum 97%, Missing); duodenum: 61.3636% (minimum 99%, Missing); esophagus: 79.4118% (minimum 80%, Enhanced); heart muscle: 93.1034% (minimum 95%, Enhanced); hippocampal formation: 79.4118% (minimum 99%, Missing); kidney: 23.2759% (minimum 99%, Missing); liver: 90.0000% (minimum 95%, Enhanced); lung: 65.8537% (minimum 95%, Enhanced); lymph node: 6.3529% (minimum 97%, Missing); pancreas: 90.0000% (minimum 95%, Enhanced); rectum: 55.1020% (minimum 97%, Missing); salivary gland: 67.5000% (minimum 80%, Enhanced); small intestine: 25.4717% (minimum 99%, Missing); smooth muscle: 87.0968% (minimum 95%, Enhanced); spleen: 14.6739% (minimum 95%, Missing); stomach: 55.1020% (minimum 80%, Enhanced); thymus: 30.0000% (minimum 95%, Missing); urinary bladder: 61.3636% (minimum 80%, Enhanced)",0,11,partial,8.9,39.8,15.7,"lymph node: 39.8 nTPM (protected, limit 2); spleen: 15.7 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); bone marrow: 5.8 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000035720,STAP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.803261,-0.906471,-0.757241
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,2.8,0.7,0.9,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000039139,DNAH5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.8919% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.1795% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.1429% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.1429% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 54.8387% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.1795% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.9268% (minimum 99%, Baseline (adaptation disabled)); liver: 79.0698% (minimum 99%, Baseline (adaptation disabled)); lung: 68.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.8919% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.0698% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 62.9630% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.1795% (minimum 97%, Baseline (adaptation disabled)); spinal cord: 97.1429% (minimum 99%, Baseline (adaptation disabled)); stomach: 89.4737% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 79.0698% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 82.9268% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,2.8,0.7,0.9,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000039139,DNAH5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.159302,-0.140732,-0.441613
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.8919% (minimum 99%, Missing); basal ganglia: 87.1795% (minimum 99%, Missing); choroid plexus: 54.8387% (minimum 99%, Missing); hippocampal formation: 87.1795% (minimum 99%, Missing); hypothalamus: 85.0000% (minimum 99%, Missing); kidney: 82.9268% (minimum 95%, Enhanced); liver: 79.0698% (minimum 95%, Enhanced); lung: 68.0000% (minimum 99%, Missing); midbrain: 91.8919% (minimum 99%, Missing); pancreas: 79.0698% (minimum 95%, Enhanced); pituitary gland: 62.9630% (minimum 99%, Missing); spinal cord: 97.1429% (minimum 99%, Missing)",0,5,partial,2.8,0.7,0.9,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000039139,DNAH5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,0.0292683,-0.441613
True,compatible,,True,True,False,,0,1,partial,0.7,0.3,0.7,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000039600,SOX30,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.7,0.3,0.7,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000039600,SOX30,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0411504,0.0261881,0.00115044
True,compatible,,True,True,True,,0,1,partial,0.7,0.3,0.7,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000039600,SOX30,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0411504,0.03,0.00872611
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,14.6,43,15.2,"stomach: 43 nTPM (protected, limit 2); skin: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); salivary gland: 13.6 nTPM (protected, limit 2); esophagus: 13.5 nTPM (protected, limit 2); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000041353,RAB27B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 88.7892% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.2553% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.5234% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.1923% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.5581% (minimum 99%, Baseline (adaptation disabled)); colon: 80.8163% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.1619% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.4595% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 88.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.5075% (minimum 99%, Baseline (adaptation disabled)); liver: 94.2857% (minimum 99%, Baseline (adaptation disabled)); lung: 74.1573% (minimum 99%, Baseline (adaptation disabled)); midbrain: 90.4110% (minimum 99%, Baseline (adaptation disabled)); pancreas: 83.5443% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.1923% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.5181% (minimum 97%, Baseline (adaptation disabled)); retina: 95.1923% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.2814% (minimum 97%, Baseline (adaptation disabled)); skin: 56.5714% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.8163% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.6522% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.5369% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.5234% (minimum 95%, Baseline (adaptation disabled)); stomach: 31.5287% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.3962% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 76.7442% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,14.6,43,15.2,"stomach: 43 nTPM (protected, limit 2); skin: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); salivary gland: 13.6 nTPM (protected, limit 2); esophagus: 13.5 nTPM (protected, limit 2); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000041353,RAB27B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.384286,-0.654713,-0.414419
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 88.7892% (minimum 99%, Missing); amygdala: 84.2553% (minimum 99%, Missing); basal ganglia: 92.5234% (minimum 99%, Missing); bone marrow: 95.1923% (minimum 99%, Missing); cerebral cortex: 57.5581% (minimum 99%, Missing); colon: 80.8163% (minimum 97%, Missing); duodenum: 80.1619% (minimum 99%, Missing); esophagus: 59.4595% (minimum 97%, Missing); hippocampal formation: 88.0000% (minimum 99%, Missing); hypothalamus: 82.5000% (minimum 99%, Missing); kidney: 98.5075% (minimum 99%, Missing); liver: 94.2857% (minimum 99%, Missing); lung: 74.1573% (minimum 99%, Missing); midbrain: 90.4110% (minimum 99%, Missing); pancreas: 83.5443% (minimum 99%, Missing); parathyroid gland: 90.0000% (minimum 97%, Missing); pituitary gland: 95.1923% (minimum 99%, Missing); rectum: 79.5181% (minimum 97%, Missing); retina: 95.1923% (minimum 99%, Missing); salivary gland: 59.2814% (minimum 97%, Missing); skin: 56.5714% (minimum 95%, Missing); small intestine: 80.8163% (minimum 99%, Missing); smooth muscle: 95.6522% (minimum 99%, Missing); spinal cord: 97.5369% (minimum 99%, Missing); spleen: 92.5234% (minimum 95%, Missing); stomach: 31.5287% (minimum 97%, Missing); thymus: 93.3962% (minimum 95%, Missing); urinary bladder: 76.7442% (minimum 97%, Missing)",0,3,partial,14.6,43,15.2,"stomach: 43 nTPM (protected, limit 2); skin: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); salivary gland: 13.6 nTPM (protected, limit 2); esophagus: 13.5 nTPM (protected, limit 2); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000041353,RAB27B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.384286,-0.654713,-0.414419
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.5,0.2,1.4,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; tonsil,ENSG00000041515,MYO16,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 41.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 58.8235% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 71.4286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 28.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); duodenum: 90.9091% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 55.5556% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 52.6316% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 35.7143% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.9231% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.9091% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 37.0370% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.9091% (minimum 97%, Baseline (adaptation disabled)); retina: 71.4286% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); skin: 90.9091% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.9091% (minimum 99%, Baseline (adaptation disabled)); tongue: 83.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.5,0.2,1.4,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; tonsil,ENSG00000041515,MYO16,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.533333,-0.136667,-0.704286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 41.6667% (minimum 95%, Missing); adrenal gland: 62.5000% (minimum 99%, Missing); amygdala: 58.8235% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); cerebellum: 71.4286% (minimum 99%, Missing); cerebral cortex: 28.5714% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); duodenum: 90.9091% (minimum 99%, Missing); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 55.5556% (minimum 99%, Missing); hippocampal formation: 52.6316% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); liver: 35.7143% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 83.3333% (minimum 97%, Missing); midbrain: 76.9231% (minimum 99%, Missing); pancreas: 90.9091% (minimum 99%, Missing); pituitary gland: 37.0370% (minimum 99%, Missing); rectum: 90.9091% (minimum 97%, Missing); retina: 71.4286% (minimum 99%, Missing); salivary gland: 90.9091% (minimum 97%, Missing); skin: 90.9091% (minimum 95%, Missing); smooth muscle: 71.4286% (minimum 99%, Missing); spinal cord: 90.9091% (minimum 99%, Missing); tongue: 83.3333% (minimum 97%, Missing)",0,80,unavailable,2.5,0.2,1.4,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; tonsil,ENSG00000041515,MYO16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.533333,-0.136667,-0.704286
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,18.6,0,0.1,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000042781,USH2A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 71.4286% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 6.9444% (minimum 99%, Baseline (adaptation disabled)); retina: 2.6178% (minimum 99%, Baseline (adaptation disabled)); thymus: 83.3333% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,18.6,0,0.1,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000042781,USH2A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.116667,0.03,-0.963822
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 71.4286% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 99%, Missing); heart muscle: 71.4286% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 6.9444% (minimum 99%, Missing); retina: 2.6178% (minimum 99%, Missing); thymus: 83.3333% (minimum 95%, Missing)",0,80,unavailable,18.6,0,0.1,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000042781,USH2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.116667,0.03,-0.963822
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,4.5,0,0.3,"retina: 4.5 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,ENSG00000042813,ZPBP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 96.8619% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,4.5,0,0.3,"retina: 4.5 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,ENSG00000042813,ZPBP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0478448,0.03,-0.0213808
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 96.8619% (minimum 99%, Missing)",0,1,partial,4.5,0,0.3,"retina: 4.5 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,ENSG00000042813,ZPBP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0213808
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,155.1,0.1,0.1,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000043355,ZIC2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); amygdala: 16.9014% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 23.0769% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 0.7678% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 10.8108% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 5.7971% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.3077% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 13.1868% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 17.6471% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.3077% (minimum 99%, Baseline (adaptation disabled)); midbrain: 24.4898% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 52.1739% (minimum 99%, Baseline (adaptation disabled)); retina: 33.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 92.3077% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 17.3913% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,155.1,0.1,0.1,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000043355,ZIC2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0269231,-0.0469231,-0.982322
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.7143% (minimum 99%, Missing); amygdala: 16.9014% (minimum 99%, Missing); basal ganglia: 23.0769% (minimum 99%, Missing); cerebellum: 0.7678% (minimum 99%, Missing); cerebral cortex: 10.8108% (minimum 99%, Missing); choroid plexus: 5.7971% (minimum 99%, Missing); esophagus: 92.3077% (minimum 97%, Missing); hippocampal formation: 13.1868% (minimum 99%, Missing); hypothalamus: 17.6471% (minimum 99%, Missing); kidney: 92.3077% (minimum 99%, Missing); midbrain: 24.4898% (minimum 99%, Missing); pituitary gland: 52.1739% (minimum 99%, Missing); retina: 33.3333% (minimum 99%, Missing); skin: 92.3077% (minimum 95%, Missing); spinal cord: 17.3913% (minimum 99%, Missing)",0,80,unavailable,155.1,0.1,0.1,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000043355,ZIC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0269231,-0.0469231,-0.982322
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,10.2,4.3,4.3,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); adrenal gland: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000044459,CNTLN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2479% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.2887% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.0575% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.2222% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 50.6849% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.8899% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.3187% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.4348% (minimum 99%, Baseline (adaptation disabled)); colon: 63.2479% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.0465% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.0833% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.0575% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.2222% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.2887% (minimum 99%, Baseline (adaptation disabled)); liver: 42.0455% (minimum 99%, Baseline (adaptation disabled)); lung: 73.2673% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.3187% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.3187% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.7931% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.8947% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.8947% (minimum 97%, Baseline (adaptation disabled)); retina: 77.8947% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.2222% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.1461% (minimum 99%, Baseline (adaptation disabled)); skin: 79.5699% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.8947% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.2479% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.5699% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.0714% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.5699% (minimum 97%, Baseline (adaptation disabled)); thymus: 73.2673% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.1538% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.2887% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.1589% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,10.2,4.3,4.3,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); adrenal gland: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000044459,CNTLN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.317521,-0.337521,-0.569545
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2479% (minimum 95%, Uncertain); adrenal gland: 76.2887% (minimum 99%, Missing); amygdala: 85.0575% (minimum 99%, Missing); basal ganglia: 82.2222% (minimum 99%, Missing); bone marrow: 50.6849% (minimum 99%, Missing); cerebellum: 67.8899% (minimum 99%, Missing); cerebral cortex: 81.3187% (minimum 99%, Missing); choroid plexus: 80.4348% (minimum 99%, Missing); colon: 63.2479% (minimum 97%, Missing); duodenum: 86.0465% (minimum 99%, Missing); esophagus: 74.0000% (minimum 97%, Missing); heart muscle: 77.0833% (minimum 99%, Missing); hippocampal formation: 85.0575% (minimum 99%, Missing); hypothalamus: 82.2222% (minimum 99%, Missing); kidney: 76.2887% (minimum 99%, Missing); liver: 42.0455% (minimum 99%, Missing); lung: 73.2673% (minimum 99%, Missing); lymph node: 74.0000% (minimum 97%, Missing); midbrain: 81.3187% (minimum 99%, Missing); pancreas: 81.3187% (minimum 99%, Missing); parathyroid gland: 63.7931% (minimum 97%, Missing); pituitary gland: 77.8947% (minimum 99%, Missing); rectum: 77.8947% (minimum 97%, Missing); retina: 77.8947% (minimum 99%, Missing); salivary gland: 82.2222% (minimum 97%, Missing); skeletal muscle: 83.1461% (minimum 99%, Missing); skin: 79.5699% (minimum 95%, Missing); small intestine: 77.8947% (minimum 99%, Missing); smooth muscle: 63.2479% (minimum 99%, Missing); spinal cord: 79.5699% (minimum 99%, Missing); spleen: 66.0714% (minimum 95%, Missing); stomach: 79.5699% (minimum 97%, Missing); thymus: 73.2673% (minimum 95%, Missing); thyroid gland: 71.1538% (minimum 95%, Missing); tongue: 76.2887% (minimum 97%, Missing); urinary bladder: 69.1589% (minimum 97%, Missing)",0,3,partial,10.2,4.3,4.3,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); adrenal gland: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000044459,CNTLN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.317521,-0.337521,-0.569545
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000046774,MAGEC2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000046774,MAGEC2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000046774,MAGEC2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,199.6,3.1,5.4,"retina: 199.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000047617,ANO2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2378% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.8889% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.6842% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.8163% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.7391% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.7526% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.1667% (minimum 99%, Baseline (adaptation disabled)); colon: 90.8163% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.7391% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.6842% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.6349% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.6842% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.6809% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.7391% (minimum 99%, Baseline (adaptation disabled)); lung: 70.6349% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.6842% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7391% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.8990% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.8022% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.6989% (minimum 97%, Baseline (adaptation disabled)); retina: 4.2686% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.6809% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.4078% (minimum 99%, Baseline (adaptation disabled)); small intestine: 92.7083% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.7083% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.4078% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.7526% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 88.1188% (minimum 95%, Baseline (adaptation disabled)); tongue: 74.1667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.0000% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,199.6,3.1,5.4,"retina: 199.6 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); skeletal muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000047617,ANO2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.327622,-0.228333,-0.947314
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.6842% (minimum 99%, Missing); basal ganglia: 90.8163% (minimum 99%, Missing); cerebral cortex: 91.7526% (minimum 95%, Enhanced); choroid plexus: 74.1667% (minimum 99%, Missing); heart muscle: 70.6349% (minimum 95%, Enhanced); hippocampal formation: 93.6842% (minimum 99%, Missing); hypothalamus: 94.6809% (minimum 99%, Missing); lung: 70.6349% (minimum 95%, Enhanced); midbrain: 93.6842% (minimum 99%, Missing); pituitary gland: 97.8022% (minimum 99%, Missing); retina: 4.2686% (minimum 99%, Missing); skeletal muscle: 86.4078% (minimum 95%, Enhanced); small intestine: 92.7083% (minimum 95%, Enhanced); smooth muscle: 89.0000% (minimum 95%, Enhanced); spinal cord: 92.7083% (minimum 99%, Missing); tongue: 74.1667% (minimum 97%, Missing)",0,3,partial,199.6,3.1,5.4,"retina: 199.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000047617,ANO2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0223776,-0.228333,-0.947314
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,21.3,21.4,23.2,"thyroid gland: 23.2 nTPM (manageable, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 4); heart muscle: 21.3 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 2); lymph node: 19.5 nTPM (protected, limit 2); skin: 18.2 nTPM (manageable, limit 5); colon: 18.1 nTPM (protected, limit 2); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 2); tongue: 16.7 nTPM (protected, limit 2); spleen: 16.5 nTPM (manageable, limit 10); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 10); small intestine: 14.6 nTPM (vital, limit 1); urinary bladder: 14.6 nTPM (protected, limit 2); stomach: 14.5 nTPM (protected, limit 2); kidney: 14 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 2); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000047932,GOPC,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.4775% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.2951% (minimum 99%, Baseline (adaptation disabled)); amygdala: 66.4723% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.5101% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.1469% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.1576% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.7204% (minimum 99%, Baseline (adaptation disabled)); colon: 55.7457% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.7061% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.0870% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.7007% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.6872% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.9573% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.9565% (minimum 99%, Baseline (adaptation disabled)); liver: 58.9147% (minimum 99%, Baseline (adaptation disabled)); lung: 63.5097% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.9007% (minimum 97%, Baseline (adaptation disabled)); midbrain: 65.8960% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.9573% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.5837% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.2208% (minimum 99%, Baseline (adaptation disabled)); rectum: 53.6471% (minimum 97%, Baseline (adaptation disabled)); retina: 63.5097% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.1253% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 55.6098% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.9626% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.2963% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.1579% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.0153% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.1260% (minimum 97%, Baseline (adaptation disabled)); thymus: 52.7778% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 49.5652% (minimum 95%, Baseline (adaptation disabled)); tongue: 57.7215% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.9626% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,21.3,21.4,23.2,"thyroid gland: 23.2 nTPM (manageable, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 2); heart muscle: 21.3 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 2); lymph node: 19.5 nTPM (protected, limit 2); skin: 18.2 nTPM (manageable, limit 5); colon: 18.1 nTPM (protected, limit 2); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 1); tongue: 16.7 nTPM (protected, limit 2); spleen: 16.5 nTPM (manageable, limit 5); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); small intestine: 14.6 nTPM (vital, limit 1); urinary bladder: 14.6 nTPM (protected, limit 2); stomach: 14.5 nTPM (protected, limit 2); kidney: 14 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 2); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000047932,GOPC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.454348,-0.454163,-0.472993
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.4775% (minimum 90%, Approved); adrenal gland: 62.2951% (minimum 99%, Missing); amygdala: 66.4723% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 76.5101% (minimum 99%, Missing); cerebellum: 53.1469% (minimum 99%, Missing); cerebral cortex: 56.1576% (minimum 99%, Missing); choroid plexus: 81.7204% (minimum 99%, Missing); colon: 55.7457% (minimum 97%, Missing); duodenum: 65.7061% (minimum 99%, Missing); esophagus: 66.0870% (minimum 97%, Missing); heart muscle: 51.7007% (minimum 99%, Missing); hippocampal formation: 63.6872% (minimum 99%, Missing); hypothalamus: 64.9573% (minimum 99%, Missing); kidney: 61.9565% (minimum 99%, Missing); liver: 58.9147% (minimum 99%, Missing); lung: 63.5097% (minimum 99%, Missing); lymph node: 53.9007% (minimum 97%, Missing); midbrain: 65.8960% (minimum 99%, Missing); pancreas: 64.9573% (minimum 99%, Missing); parathyroid gland: 51.5837% (minimum 95%, Approved); pituitary gland: 59.2208% (minimum 99%, Missing); rectum: 53.6471% (minimum 97%, Missing); retina: 63.5097% (minimum 99%, Missing); salivary gland: 62.1253% (minimum 97%, Missing); skeletal muscle: 60.0000% (minimum 99%, Missing); skin: 55.6098% (minimum 95%, Missing); small intestine: 60.9626% (minimum 99%, Missing); smooth muscle: 56.2963% (minimum 98%, Approved); spinal cord: 63.1579% (minimum 99%, Missing); spleen: 58.0153% (minimum 90%, Approved); stomach: 61.1260% (minimum 97%, Missing); thymus: 52.7778% (minimum 95%, Missing); thyroid gland: 49.5652% (minimum 95%, Missing); tongue: 57.7215% (minimum 97%, Missing); urinary bladder: 60.9626% (minimum 97%, Missing)",0,4,partial,21.3,21.4,23.2,"thyroid gland: 23.2 nTPM (manageable, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 4); heart muscle: 21.3 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 2); lymph node: 19.5 nTPM (protected, limit 2); skin: 18.2 nTPM (manageable, limit 5); colon: 18.1 nTPM (protected, limit 2); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 2); tongue: 16.7 nTPM (protected, limit 2); spleen: 16.5 nTPM (manageable, limit 10); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 10); small intestine: 14.6 nTPM (vital, limit 1); urinary bladder: 14.6 nTPM (protected, limit 2); stomach: 14.5 nTPM (protected, limit 2); kidney: 14 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 2); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000047932,GOPC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.454348,-0.434163,-0.472993
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,734.2,0.1,0.1,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,ENSG00000048545,GUCA1A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.6744% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.8235% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.3226% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.7778% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8235% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.4545% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.8235% (minimum 99%, Baseline (adaptation disabled)); retina: 1.1312% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.8235% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.8235% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,734.2,0.1,0.1,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,ENSG00000048545,GUCA1A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0382353,0.0182353,-0.978688
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.6744% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); cerebral cortex: 90.3226% (minimum 97%, Supported); choroid plexus: 77.7778% (minimum 99%, Missing); hippocampal formation: 98.8235% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); midbrain: 98.8235% (minimum 99%, Missing); retina: 1.1312% (minimum 99%, Missing)",0,0,routine_complete,734.2,0.1,0.1,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,ENSG00000048545,GUCA1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.978688
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4,4,4,"tongue: 4 nTPM (protected, limit 2); spinal cord: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); amygdala: 3.4 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); pancreas: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000049167,ERCC8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.9481% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.1429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 54.0541% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.7945% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.6061% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.7273% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.8235% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.1754% (minimum 99%, Baseline (adaptation disabled)); colon: 55.5556% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.5385% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.7015% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.0541% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.1429% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.5556% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 54.0541% (minimum 99%, Baseline (adaptation disabled)); lung: 65.5738% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 51.9481% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.6061% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 53.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.5000% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.0541% (minimum 97%, Baseline (adaptation disabled)); retina: 52.6316% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.6061% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 57.9710% (minimum 99%, Baseline (adaptation disabled)); skin: 63.4921% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.5161% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 54.7945% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.1429% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.5385% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.9710% (minimum 95%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4,4,4,"tongue: 4 nTPM (protected, limit 2); spinal cord: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); amygdala: 3.4 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); pancreas: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000049167,ERCC8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.45,-0.47,-0.49
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.9481% (minimum 95%, Missing); adrenal gland: 57.1429% (minimum 99%, Missing); amygdala: 54.0541% (minimum 99%, Missing); basal ganglia: 54.7945% (minimum 99%, Missing); bone marrow: 60.6061% (minimum 99%, Missing); cerebellum: 72.7273% (minimum 99%, Missing); cerebral cortex: 58.8235% (minimum 99%, Missing); choroid plexus: 70.1754% (minimum 99%, Missing); colon: 55.5556% (minimum 97%, Missing); duodenum: 61.5385% (minimum 99%, Missing); esophagus: 59.7015% (minimum 97%, Missing); heart muscle: 54.0541% (minimum 99%, Missing); hippocampal formation: 57.1429% (minimum 99%, Missing); hypothalamus: 55.5556% (minimum 99%, Missing); kidney: 50.0000% (minimum 99%, Missing); liver: 54.0541% (minimum 99%, Missing); lung: 65.5738% (minimum 99%, Missing); lymph node: 62.5000% (minimum 97%, Missing); midbrain: 51.9481% (minimum 99%, Missing); pancreas: 60.6061% (minimum 99%, Missing); parathyroid gland: 53.3333% (minimum 97%, Missing); pituitary gland: 62.5000% (minimum 99%, Missing); rectum: 54.0541% (minimum 97%, Missing); retina: 52.6316% (minimum 99%, Missing); salivary gland: 60.6061% (minimum 97%, Missing); skeletal muscle: 57.9710% (minimum 99%, Missing); skin: 63.4921% (minimum 95%, Missing); small intestine: 64.5161% (minimum 99%, Missing); smooth muscle: 54.7945% (minimum 99%, Missing); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 57.1429% (minimum 95%, Missing); stomach: 61.5385% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing); thyroid gland: 57.9710% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",0,80,unavailable,4,4,4,"tongue: 4 nTPM (protected, limit 2); spinal cord: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); amygdala: 3.4 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); pancreas: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000049167,ERCC8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.45,-0.47,-0.49
True,compatible,,True,True,False,,0,2,partial,0.6,0.7,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000049192,ADAMTS6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 78.2609% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.7368% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.7368% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.7368% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.8182% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.2609% (minimum 99%, Baseline (adaptation disabled)); colon: 85.7143% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.7368% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.7368% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.7368% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 78.2609% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.8182% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.7368% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.7368% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 90.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.7368% (minimum 97%, Baseline (adaptation disabled)); skin: 94.7368% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.7368% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.7143% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.7368% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.7368% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.0000% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,0.6,0.7,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000049192,ADAMTS6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.2,-0.25,-0.24
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.7368% (minimum 95%, Enhanced); amygdala: 94.7368% (minimum 99%, Missing); basal ganglia: 94.7368% (minimum 99%, Missing); cerebral cortex: 81.8182% (minimum 95%, Enhanced); choroid plexus: 78.2609% (minimum 99%, Missing); duodenum: 94.7368% (minimum 95%, Enhanced); heart muscle: 85.7143% (minimum 95%, Enhanced); hippocampal formation: 94.7368% (minimum 99%, Missing); hypothalamus: 94.7368% (minimum 99%, Missing); kidney: 90.0000% (minimum 95%, Enhanced); lung: 78.2609% (minimum 95%, Enhanced); midbrain: 94.7368% (minimum 99%, Missing); pituitary gland: 94.7368% (minimum 99%, Missing); retina: 90.0000% (minimum 99%, Missing); small intestine: 75.0000% (minimum 95%, Enhanced); smooth muscle: 75.0000% (minimum 95%, Enhanced); spinal cord: 94.7368% (minimum 99%, Missing); thymus: 90.0000% (minimum 95%, Missing); tongue: 94.7368% (minimum 97%, Missing); urinary bladder: 72.0000% (minimum 80%, Enhanced)",0,2,partial,0.6,0.7,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000049192,ADAMTS6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.05,-0.08,-0.207391
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,2.3,5.6,6.6,"thymus: 6.6 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2)",lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000049768,FOXP3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.1538% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.2857% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.2857% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.2069% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.2857% (minimum 99%, Baseline (adaptation disabled)); colon: 89.2857% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.2857% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.9672% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.0392% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.2857% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.5926% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.3396% (minimum 99%, Baseline (adaptation disabled)); liver: 68.4932% (minimum 99%, Baseline (adaptation disabled)); lung: 86.2069% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.1698% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.5926% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0392% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.1538% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.9091% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.9091% (minimum 97%, Baseline (adaptation disabled)); retina: 92.5926% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 84.7458% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.3396% (minimum 99%, Baseline (adaptation disabled)); skin: 72.4638% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.5294% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.3396% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.3396% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.4932% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.7576% (minimum 97%, Baseline (adaptation disabled)); thymus: 43.1034% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.5926% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 65.7895% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,2.3,5.6,6.6,"thymus: 6.6 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); liver: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000049768,FOXP3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.518966,-0.498302,-0.305068
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 89.2857% (minimum 99%, Missing); basal ganglia: 89.2857% (minimum 99%, Missing); bone marrow: 83.3333% (minimum 95%, Enhanced); cerebellum: 86.2069% (minimum 95%, Enhanced); cerebral cortex: 89.2857% (minimum 95%, Enhanced); duodenum: 89.2857% (minimum 95%, Enhanced); hippocampal formation: 89.2857% (minimum 99%, Missing); hypothalamus: 92.5926% (minimum 99%, Missing); kidney: 94.3396% (minimum 95%, Enhanced); liver: 68.4932% (minimum 95%, Enhanced); lung: 86.2069% (minimum 99%, Missing); lymph node: 47.1698% (minimum 97%, Missing); midbrain: 92.5926% (minimum 99%, Missing); pituitary gland: 90.9091% (minimum 99%, Missing); retina: 92.5926% (minimum 99%, Missing); skeletal muscle: 94.3396% (minimum 95%, Enhanced); small intestine: 73.5294% (minimum 95%, Enhanced); smooth muscle: 94.3396% (minimum 95%, Enhanced); spinal cord: 94.3396% (minimum 99%, Missing); spleen: 68.4932% (minimum 95%, Missing); stomach: 75.7576% (minimum 80%, Enhanced); thymus: 43.1034% (minimum 95%, Missing); urinary bladder: 65.7895% (minimum 80%, Enhanced)",0,2,partial,2.3,5.6,6.6,"thymus: 6.6 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2)",lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000049768,FOXP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.518966,-0.498302,-0.265068
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,3,1.8,0.4,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000050030,NEXMIF,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 90.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 45.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 37.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 33.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 23.0769% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.2308% (minimum 99%, Baseline (adaptation disabled)); colon: 52.9412% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.8182% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 47.3684% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 30.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.2500% (minimum 99%, Baseline (adaptation disabled)); lung: 90.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.2857% (minimum 99%, Baseline (adaptation disabled)); pancreas: 39.1304% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 33.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 34.6154% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.2308% (minimum 97%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.2308% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.2500% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.0000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 69.2308% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 81.8182% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3,1.8,0.4,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000050030,NEXMIF,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.257692,-0.636667,-0.759231
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 90.0000% (minimum 95%, Missing); adrenal gland: 50.0000% (minimum 99%, Missing); amygdala: 45.0000% (minimum 99%, Missing); basal ganglia: 37.5000% (minimum 99%, Missing); cerebellum: 33.3333% (minimum 99%, Missing); cerebral cortex: 23.0769% (minimum 99%, Missing); choroid plexus: 69.2308% (minimum 99%, Missing); colon: 52.9412% (minimum 97%, Missing); duodenum: 90.0000% (minimum 99%, Missing); esophagus: 81.8182% (minimum 97%, Missing); hippocampal formation: 47.3684% (minimum 99%, Missing); hypothalamus: 30.0000% (minimum 99%, Missing); kidney: 56.2500% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); lymph node: 90.0000% (minimum 97%, Missing); midbrain: 64.2857% (minimum 99%, Missing); pancreas: 39.1304% (minimum 99%, Missing); parathyroid gland: 33.3333% (minimum 97%, Missing); pituitary gland: 34.6154% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 69.2308% (minimum 97%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 69.2308% (minimum 99%, Missing); smooth muscle: 56.2500% (minimum 99%, Missing); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 90.0000% (minimum 95%, Missing); stomach: 60.0000% (minimum 97%, Missing); thyroid gland: 69.2308% (minimum 95%, Missing); tongue: 90.0000% (minimum 97%, Missing); urinary bladder: 81.8182% (minimum 97%, Missing)",0,80,unavailable,3,1.8,0.4,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000050030,NEXMIF,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.257692,-0.636667,-0.759231
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,10.3,10.7,15.2,"thymus: 15.2 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 2); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); colon: 8 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / sebaceous glands: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thymus / cortical cells: High (Enhanced); thymus / medullary cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / langerhans cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / sebaceous glands; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000051180,RAD51,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.9167% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.7395% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.5266% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.3264% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.9167% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.3264% (minimum 99%, Baseline (adaptation disabled)); colon: 74.6032% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.0150% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.4545% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.9167% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.9167% (minimum 99%, Baseline (adaptation disabled)); liver: 94.7581% (minimum 99%, Baseline (adaptation disabled)); lung: 95.5285% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.7135% (minimum 97%, Baseline (adaptation disabled)); pancreas: 94.7581% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.7554% (minimum 97%, Baseline (adaptation disabled)); retina: 98.7395% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.9184% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.9184% (minimum 99%, Baseline (adaptation disabled)); skin: 88.6792% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.4545% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.0853% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.0853% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.8854% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.7235% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.2540% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,10.3,10.7,15.2,"thymus: 15.2 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 2); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); colon: 8 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / sebaceous glands: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thymus / cortical cells: High (Enhanced); thymus / medullary cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / langerhans cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / sebaceous glands; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000051180,RAD51,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.342765,-0.282865,-0.294734
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.9167% (minimum 99%, Missing); basal ganglia: 98.7395% (minimum 99%, Missing); bone marrow: 69.5266% (minimum 99%, Missing); choroid plexus: 98.3264% (minimum 99%, Missing); colon: 74.6032% (minimum 97%, Missing); duodenum: 88.0150% (minimum 99%, Missing); esophagus: 85.4545% (minimum 97%, Missing); kidney: 97.9167% (minimum 99%, Missing); liver: 94.7581% (minimum 95%, Enhanced); lung: 95.5285% (minimum 99%, Missing); lymph node: 68.7135% (minimum 97%, Missing); pancreas: 94.7581% (minimum 95%, Enhanced); rectum: 72.7554% (minimum 97%, Missing); retina: 98.7395% (minimum 99%, Missing); salivary gland: 95.9184% (minimum 97%, Missing); skin: 88.6792% (minimum 95%, Missing); small intestine: 85.4545% (minimum 99%, Missing); smooth muscle: 91.0853% (minimum 95%, Enhanced); stomach: 92.8854% (minimum 97%, Missing); thymus: 60.7235% (minimum 95%, Missing); urinary bladder: 93.2540% (minimum 97%, Missing)",0,6,partial,10.3,10.7,15.2,"thymus: 15.2 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 2); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); colon: 8 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / sebaceous glands: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thymus / cortical cells: High (Enhanced); thymus / medullary cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / langerhans cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / sebaceous glands; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000051180,RAD51,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.342765,-0.282865,-0.294734
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.9,2.7,4.3,"bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000051341,POLQ,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.3043% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 26.2500% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.4545% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.4545% (minimum 99%, Baseline (adaptation disabled)); colon: 63.6364% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.6250% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.3043% (minimum 99%, Baseline (adaptation disabled)); liver: 95.4545% (minimum 99%, Baseline (adaptation disabled)); lung: 91.3043% (minimum 99%, Baseline (adaptation disabled)); lymph node: 43.7500% (minimum 97%, Baseline (adaptation disabled)); parathyroid gland: 95.4545% (minimum 97%, Baseline (adaptation disabled)); rectum: 52.5000% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 91.3043% (minimum 97%, Baseline (adaptation disabled)); skin: 60.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.4138% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.7692% (minimum 97%, Baseline (adaptation disabled)); thymus: 32.8125% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 87.5000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.9,2.7,4.3,"bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000051341,POLQ,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.621875,-0.5325,-0.7275
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.3043% (minimum 99%, Missing); bone marrow: 26.2500% (minimum 99%, Missing); cerebellum: 95.4545% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); colon: 63.6364% (minimum 97%, Missing); duodenum: 65.6250% (minimum 99%, Missing); esophagus: 52.5000% (minimum 97%, Missing); heart muscle: 91.3043% (minimum 99%, Missing); liver: 95.4545% (minimum 99%, Missing); lung: 91.3043% (minimum 99%, Missing); lymph node: 43.7500% (minimum 97%, Missing); parathyroid gland: 95.4545% (minimum 97%, Missing); rectum: 52.5000% (minimum 97%, Missing); salivary gland: 91.3043% (minimum 97%, Missing); skin: 60.0000% (minimum 95%, Missing); small intestine: 70.0000% (minimum 99%, Missing); smooth muscle: 84.0000% (minimum 99%, Missing); spleen: 72.4138% (minimum 95%, Missing); stomach: 80.7692% (minimum 97%, Missing); thymus: 32.8125% (minimum 95%, Missing); urinary bladder: 87.5000% (minimum 97%, Missing)",0,80,unavailable,5.9,2.7,4.3,"bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000051341,POLQ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.621875,-0.5325,-0.7275
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000054796,SPO11,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000054796,SPO11,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000054796,SPO11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,1807.4,5.1,7.2,"liver: 1807.4 nTPM (vital, limit 6); pancreas: 47.5 nTPM (vital, limit 6); skeletal muscle: 38.8 nTPM (vital, limit 6); adrenal gland: 17.9 nTPM (vital, limit 6); bone marrow: 9.9 nTPM (vital, limit 6); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000055955,ITIH4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.6173% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 18.6364% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.2941% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 29.2857% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.9474% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.1644% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.2941% (minimum 99%, Baseline (adaptation disabled)); colon: 53.9474% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.5455% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 56.9444% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 69.4915% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.6897% (minimum 99%, Baseline (adaptation disabled)); kidney: 44.0860% (minimum 99%, Baseline (adaptation disabled)); liver: 0.2263% (minimum 99%, Baseline (adaptation disabled)); lung: 46.5909% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.9298% (minimum 97%, Baseline (adaptation disabled)); midbrain: 67.2131% (minimum 99%, Baseline (adaptation disabled)); pancreas: 7.9457% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 49.3976% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.3922% (minimum 97%, Baseline (adaptation disabled)); retina: 56.1644% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 67.2131% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 9.5571% (minimum 99%, Baseline (adaptation disabled)); skin: 63.0769% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.4054% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 74.5455% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.5455% (minimum 99%, Baseline (adaptation disabled)); spleen: 36.2832% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.5641% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.1290% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 44.5652% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.2941% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 44.5652% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,1807.4,5.1,7.2,"liver: 1807.4 nTPM (vital, limit 1); pancreas: 47.5 nTPM (vital, limit 1); skeletal muscle: 38.8 nTPM (vital, limit 1); adrenal gland: 17.9 nTPM (vital, limit 1); bone marrow: 9.9 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 2); lung: 4.7 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000055955,ITIH4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.587168,-0.524348,-0.987737
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.6173% (minimum 60%, Enhanced); adrenal gland: 18.6364% (minimum 95%, Enhanced); amygdala: 68.3333% (minimum 99%, Missing); basal ganglia: 60.2941% (minimum 99%, Missing); bone marrow: 29.2857% (minimum 95%, Enhanced); cerebellum: 53.9474% (minimum 95%, Enhanced); cerebral cortex: 56.1644% (minimum 95%, Enhanced); choroid plexus: 60.2941% (minimum 99%, Missing); colon: 53.9474% (minimum 80%, Enhanced); duodenum: 82.0000% (minimum 95%, Enhanced); esophagus: 74.5455% (minimum 80%, Enhanced); heart muscle: 56.9444% (minimum 95%, Enhanced); hippocampal formation: 69.4915% (minimum 99%, Missing); hypothalamus: 70.6897% (minimum 99%, Missing); kidney: 44.0860% (minimum 95%, Enhanced); liver: 0.2263% (minimum 95%, Enhanced); lung: 46.5909% (minimum 95%, Enhanced); lymph node: 71.9298% (minimum 80%, Enhanced); midbrain: 67.2131% (minimum 99%, Missing); pancreas: 7.9457% (minimum 95%, Enhanced); pituitary gland: 49.3976% (minimum 99%, Missing); retina: 56.1644% (minimum 99%, Missing); salivary gland: 67.2131% (minimum 80%, Enhanced); skeletal muscle: 9.5571% (minimum 95%, Enhanced); small intestine: 55.4054% (minimum 95%, Enhanced); smooth muscle: 74.5455% (minimum 95%, Enhanced); spinal cord: 74.5455% (minimum 99%, Missing); spleen: 36.2832% (minimum 60%, Enhanced); stomach: 52.5641% (minimum 80%, Enhanced); thymus: 66.1290% (minimum 95%, Missing); thyroid gland: 44.5652% (minimum 60%, Enhanced); tongue: 60.2941% (minimum 97%, Missing); urinary bladder: 44.5652% (minimum 80%, Enhanced)",0,1,partial,1807.4,5.1,7.2,"liver: 1807.4 nTPM (vital, limit 6); pancreas: 47.5 nTPM (vital, limit 6); skeletal muscle: 38.8 nTPM (vital, limit 6); adrenal gland: 17.9 nTPM (vital, limit 6); bone marrow: 9.9 nTPM (vital, limit 6); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000055955,ITIH4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.28871,-0.367059,-0.947737
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,2.6,2.2,2.1,"bone marrow: 2.6 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000056277,ZNF280C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 85.0467% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.0990% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.7778% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.8491% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.8491% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.7917% (minimum 99%, Baseline (adaptation disabled)); colon: 86.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.5000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.0990% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.3495% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.2157% (minimum 99%, Baseline (adaptation disabled)); liver: 88.3495% (minimum 99%, Baseline (adaptation disabled)); lung: 86.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.5310% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.0990% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.3495% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.0467% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.8491% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 83.4862% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.2157% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 85.0467% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.2593% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.3495% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.0467% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.2157% (minimum 97%, Baseline (adaptation disabled)); thymus: 81.2500% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.8491% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.0990% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.8491% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,2.6,2.2,2.1,"bone marrow: 2.6 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000056277,ZNF280C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.1375,-0.16469,-0.212222
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 86.6667% (minimum 99%, Missing); amygdala: 90.0990% (minimum 99%, Missing); basal ganglia: 91.0000% (minimum 99%, Missing); bone marrow: 77.7778% (minimum 99%, Missing); cerebellum: 85.8491% (minimum 99%, Missing); cerebral cortex: 85.8491% (minimum 99%, Missing); choroid plexus: 94.7917% (minimum 99%, Missing); colon: 86.6667% (minimum 97%, Missing); duodenum: 87.5000% (minimum 99%, Missing); esophagus: 87.5000% (minimum 97%, Missing); heart muscle: 91.0000% (minimum 99%, Missing); hippocampal formation: 90.0990% (minimum 99%, Missing); hypothalamus: 88.3495% (minimum 99%, Missing); kidney: 89.2157% (minimum 99%, Missing); liver: 88.3495% (minimum 99%, Missing); lung: 86.6667% (minimum 99%, Missing); lymph node: 80.5310% (minimum 97%, Missing); midbrain: 90.0990% (minimum 99%, Missing); pancreas: 88.3495% (minimum 99%, Missing); parathyroid gland: 85.0467% (minimum 97%, Missing); pituitary gland: 85.8491% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 83.4862% (minimum 99%, Missing); salivary gland: 89.2157% (minimum 97%, Missing); skeletal muscle: 87.5000% (minimum 99%, Missing); skin: 85.0467% (minimum 95%, Missing); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 84.2593% (minimum 99%, Missing); spinal cord: 88.3495% (minimum 99%, Missing); spleen: 85.0467% (minimum 95%, Missing); stomach: 89.2157% (minimum 97%, Missing); thymus: 81.2500% (minimum 95%, Missing); thyroid gland: 85.8491% (minimum 95%, Missing); tongue: 90.0990% (minimum 97%, Missing); urinary bladder: 85.8491% (minimum 97%, Missing)",0,2,partial,2.6,2.2,2.1,"bone marrow: 2.6 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000056277,ZNF280C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.1375,-0.16469,-0.212222
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.7,0.4,7,"thymus: 7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000056291,NPFFR2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 93.9394% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.9394% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.1765% (minimum 99%, Baseline (adaptation disabled)); colon: 96.8750% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.8750% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.5714% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.8750% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.8750% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.9394% (minimum 97%, Baseline (adaptation disabled)); retina: 81.5789% (minimum 99%, Baseline (adaptation disabled)); thymus: 30.6931% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.5714% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.9394% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.5714% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.4,7,"thymus: 7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000056291,NPFFR2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.643069,-0.0842857,-0.174211
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 93.9394% (minimum 99%, Missing); basal ganglia: 93.9394% (minimum 99%, Missing); cerebral cortex: 91.1765% (minimum 99%, Missing); colon: 96.8750% (minimum 97%, Missing); duodenum: 96.8750% (minimum 99%, Missing); hypothalamus: 88.5714% (minimum 99%, Missing); lymph node: 96.8750% (minimum 97%, Missing); pituitary gland: 96.8750% (minimum 99%, Missing); rectum: 93.9394% (minimum 97%, Missing); retina: 81.5789% (minimum 99%, Missing); thymus: 30.6931% (minimum 95%, Missing); thyroid gland: 88.5714% (minimum 95%, Missing); tongue: 93.9394% (minimum 97%, Missing); urinary bladder: 88.5714% (minimum 97%, Missing)",0,80,unavailable,0.7,0.4,7,"thymus: 7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000056291,NPFFR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.643069,-0.0842857,-0.174211
True,compatible,,True,True,False,,0,80,unavailable,1,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000057468,MSH4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.6190% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.6190% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.6190% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.6190% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.3922% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.3488% (minimum 99%, Baseline (adaptation disabled)); colon: 93.1818% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.1818% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6190% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.6190% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.6190% (minimum 99%, Baseline (adaptation disabled)); liver: 97.6190% (minimum 99%, Baseline (adaptation disabled)); lung: 95.3488% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.6190% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.6190% (minimum 99%, Baseline (adaptation disabled)); retina: 87.2340% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 85.4167% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.3488% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.6190% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.3488% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.1304% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.1818% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000057468,MSH4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0586957,-0.0381818,-0.186078
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.6190% (minimum 99%, Missing); amygdala: 97.6190% (minimum 99%, Missing); basal ganglia: 97.6190% (minimum 99%, Missing); bone marrow: 97.6190% (minimum 99%, Missing); cerebellum: 80.3922% (minimum 99%, Missing); cerebral cortex: 95.3488% (minimum 99%, Missing); colon: 93.1818% (minimum 97%, Missing); heart muscle: 93.1818% (minimum 99%, Missing); hippocampal formation: 97.6190% (minimum 99%, Missing); hypothalamus: 97.6190% (minimum 99%, Missing); kidney: 97.6190% (minimum 99%, Missing); liver: 97.6190% (minimum 99%, Missing); lung: 95.3488% (minimum 99%, Missing); midbrain: 97.6190% (minimum 99%, Missing); pancreas: 97.6190% (minimum 99%, Missing); retina: 87.2340% (minimum 99%, Missing); skeletal muscle: 85.4167% (minimum 99%, Missing); small intestine: 95.3488% (minimum 99%, Missing); smooth muscle: 97.6190% (minimum 99%, Missing); spinal cord: 95.3488% (minimum 99%, Missing); spleen: 89.1304% (minimum 95%, Missing); urinary bladder: 93.1818% (minimum 97%, Missing)",0,80,unavailable,1,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000057468,MSH4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0586957,-0.0381818,-0.186078
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,5.7,4.3,4,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); salivary gland: 2.9 nTPM (protected, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 2); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000062370,ZNF112,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.0225% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.5686% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.8421% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.8421% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6486% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.1538% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.2772% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.3478% (minimum 99%, Baseline (adaptation disabled)); colon: 71.5686% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.4898% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.4898% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.8679% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.2577% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.2577% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 82.9545% (minimum 99%, Baseline (adaptation disabled)); lung: 75.2577% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.1235% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.4898% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.2577% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.9310% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.8679% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.2772% (minimum 97%, Baseline (adaptation disabled)); retina: 59.3496% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.5686% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.2198% (minimum 99%, Baseline (adaptation disabled)); skin: 73.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.7374% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.2772% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.4946% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.1923% (minimum 97%, Baseline (adaptation disabled)); thymus: 83.9080% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.6018% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.2577% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.8421% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,5.7,4.3,4,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); salivary gland: 2.9 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); midbrain: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000062370,ZNF112,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.303982,-0.34069,-0.428462
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.0225% (minimum 90%, Approved); adrenal gland: 71.5686% (minimum 99%, Missing); amygdala: 76.8421% (minimum 99%, Missing); basal ganglia: 76.8421% (minimum 99%, Missing); cerebellum: 56.1538% (minimum 99%, Missing); cerebral cortex: 72.2772% (minimum 99%, Missing); choroid plexus: 79.3478% (minimum 99%, Missing); colon: 71.5686% (minimum 97%, Missing); duodenum: 74.4898% (minimum 99%, Missing); esophagus: 74.4898% (minimum 95%, Approved); heart muscle: 68.8679% (minimum 99%, Missing); hippocampal formation: 75.2577% (minimum 99%, Missing); hypothalamus: 75.2577% (minimum 99%, Missing); kidney: 73.0000% (minimum 99%, Missing); liver: 82.9545% (minimum 98%, Approved); lung: 75.2577% (minimum 99%, Missing); lymph node: 90.1235% (minimum 95%, Approved); midbrain: 74.4898% (minimum 99%, Missing); pancreas: 75.2577% (minimum 98%, Approved); parathyroid gland: 62.9310% (minimum 97%, Missing); pituitary gland: 68.8679% (minimum 99%, Missing); rectum: 72.2772% (minimum 95%, Approved); retina: 59.3496% (minimum 99%, Missing); salivary gland: 71.5686% (minimum 97%, Missing); skeletal muscle: 80.2198% (minimum 99%, Missing); skin: 73.0000% (minimum 90%, Approved); small intestine: 73.7374% (minimum 99%, Missing); smooth muscle: 73.0000% (minimum 99%, Missing); spinal cord: 72.2772% (minimum 99%, Missing); spleen: 78.4946% (minimum 90%, Approved); stomach: 70.1923% (minimum 95%, Approved); thymus: 83.9080% (minimum 95%, Missing); thyroid gland: 64.6018% (minimum 90%, Approved); tongue: 75.2577% (minimum 97%, Missing); urinary bladder: 76.8421% (minimum 95%, Approved)",0,0,routine_complete,5.7,4.3,4,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); salivary gland: 2.9 nTPM (protected, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 2); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000062370,ZNF112,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.253982,-0.34069,-0.428462
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,15.5,6.7,4.6,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 2); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000063127,SLC6A16,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9636% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.3854% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.1740% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.0084% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.5005% (minimum 99%, Baseline (adaptation disabled)); colon: 96.1094% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.4414% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.3854% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.3854% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.6750% (minimum 99%, Baseline (adaptation disabled)); liver: 90.4055% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0104% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.1702% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.8108% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.1702% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.3854% (minimum 99%, Baseline (adaptation disabled)); retina: 95.0104% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.9177% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.2105% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.1740% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.4135% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.3119% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,15.5,6.7,4.6,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 2); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000063127,SLC6A16,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00208333,-0.0382977,-0.134995
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9636% (minimum 99%, Missing); amygdala: 98.3854% (minimum 99%, Missing); basal ganglia: 98.1740% (minimum 99%, Missing); bone marrow: 96.0084% (minimum 99%, Missing); choroid plexus: 85.5005% (minimum 99%, Missing); colon: 96.1094% (minimum 97%, Missing); heart muscle: 97.4414% (minimum 99%, Missing); hippocampal formation: 98.3854% (minimum 99%, Missing); hypothalamus: 98.3854% (minimum 99%, Missing); kidney: 91.6750% (minimum 99%, Missing); liver: 90.4055% (minimum 99%, Missing); lung: 95.0104% (minimum 99%, Missing); lymph node: 93.1702% (minimum 97%, Missing); midbrain: 98.8108% (minimum 99%, Missing); pancreas: 93.1702% (minimum 99%, Missing); pituitary gland: 98.3854% (minimum 99%, Missing); retina: 95.0104% (minimum 99%, Missing); skeletal muscle: 98.9177% (minimum 99%, Missing); small intestine: 96.2105% (minimum 99%, Missing); smooth muscle: 98.1740% (minimum 99%, Missing); stomach: 96.4135% (minimum 97%, Missing); urinary bladder: 96.3119% (minimum 97%, Missing)",0,80,unavailable,15.5,6.7,4.6,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 2); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000063127,SLC6A16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00208333,-0.0382977,-0.134995
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.1,3.3,5.8,"skin: 5.8 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000063438,AHRR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4716% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.1983% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.4716% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.5508% (minimum 99%, Baseline (adaptation disabled)); colon: 95.7537% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.4716% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.3488% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.9035% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.5739% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.1983% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.7811% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6871% (minimum 99%, Baseline (adaptation disabled)); lung: 95.5508% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6871% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.7811% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.9035% (minimum 99%, Baseline (adaptation disabled)); skin: 88.6051% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.1620% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.9546% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.1818% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.1,3.3,5.8,"skin: 5.8 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000063438,AHRR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0639489,-0.0381818,-0.0344915
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4716% (minimum 99%, Missing); amygdala: 97.1983% (minimum 99%, Missing); basal ganglia: 98.4716% (minimum 99%, Missing); cerebral cortex: 95.5508% (minimum 99%, Missing); colon: 95.7537% (minimum 97%, Missing); duodenum: 98.4716% (minimum 99%, Missing); esophagus: 95.3488% (minimum 97%, Missing); heart muscle: 98.9035% (minimum 99%, Missing); hippocampal formation: 96.5739% (minimum 99%, Missing); hypothalamus: 97.1983% (minimum 99%, Missing); kidney: 96.7811% (minimum 99%, Missing); liver: 98.6871% (minimum 99%, Missing); lung: 95.5508% (minimum 99%, Missing); pancreas: 98.6871% (minimum 99%, Missing); pituitary gland: 96.7811% (minimum 99%, Missing); skeletal muscle: 98.9035% (minimum 99%, Missing); skin: 88.6051% (minimum 95%, Missing); small intestine: 96.1620% (minimum 99%, Missing); spleen: 88.9546% (minimum 95%, Missing); urinary bladder: 93.1818% (minimum 97%, Missing)",0,80,unavailable,2.1,3.3,5.8,"skin: 5.8 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000063438,AHRR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0639489,-0.0381818,-0.0344915
True,compatible,,True,True,False,,0,0,routine_complete,1,0,0,,,55,not_established,not_triggered,,,ENSG00000063515,GSC2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 68.7500% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,1,0,0,,,55,not_established,not_triggered,,,ENSG00000063515,GSC2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.3025
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 68.7500% (minimum 99%, Missing)",0,0,routine_complete,1,0,0,,,55,not_established,not_triggered,,,ENSG00000063515,GSC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.3025
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,9,partial,16.1,5.2,8.6,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 6); midbrain: 9.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); spinal cord: 5.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000064199,SPA17,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.2517% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.9324% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.3745% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.6596% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.6667% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.0803% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.6925% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.3167% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.2139% (minimum 99%, Baseline (adaptation disabled)); lung: 96.8131% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.9863% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1659% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.4935% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.7264% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.5271% (minimum 99%, Baseline (adaptation disabled))",0,9,partial,16.1,5.2,8.6,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); thyroid gland: 8.6 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 2); esophagus: 4.9 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 2); heart muscle: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000064199,SPA17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0131534,0.0073913,-0.0568327
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 94.9324% (minimum 99%, Missing); basal ganglia: 94.3745% (minimum 99%, Missing); choroid plexus: 93.6667% (minimum 99%, Missing); hippocampal formation: 94.6925% (minimum 99%, Missing); hypothalamus: 93.3167% (minimum 99%, Missing); kidney: 95.2139% (minimum 99%, Missing); midbrain: 95.9863% (minimum 99%, Missing); pituitary gland: 94.4935% (minimum 99%, Missing); spinal cord: 97.5271% (minimum 99%, Missing)",0,9,partial,16.1,5.2,8.6,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 6); midbrain: 9.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); spinal cord: 5.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000064199,SPA17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0390013,0.0291111,-0.0568327
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,8.5,3.8,4.7,"skeletal muscle: 8.5 nTPM (vital, limit 6); small intestine: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); urinary bladder: 3.8 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000064703,DDX20,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.1005% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.6131% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.8879% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.7090% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.7090% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.9560% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.5307% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.2759% (minimum 99%, Baseline (adaptation disabled)); colon: 93.1034% (minimum 97%, Baseline (adaptation disabled)); esophagus: 94.1284% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.6131% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.0674% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.0674% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.6494% (minimum 99%, Baseline (adaptation disabled)); liver: 95.3532% (minimum 99%, Baseline (adaptation disabled)); lung: 94.3015% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.6494% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.7925% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.6131% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.5307% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.6102% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.4286% (minimum 97%, Baseline (adaptation disabled)); retina: 98.4645% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.1284% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.7860% (minimum 99%, Baseline (adaptation disabled)); skin: 93.6131% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.4324% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1591% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.6071% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.2727% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.4426% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.3015% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.7925% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 93.1034% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,8.5,3.8,4.7,"skeletal muscle: 8.5 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); colon: 3.8 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000064703,DDX20,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0339286,-0.0389655,-0.13214
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.6131% (minimum 95%, Enhanced); amygdala: 95.8879% (minimum 99%, Missing); basal ganglia: 95.7090% (minimum 99%, Missing); cerebellum: 93.9560% (minimum 95%, Enhanced); choroid plexus: 98.2759% (minimum 99%, Missing); colon: 93.1034% (minimum 97%, Missing); esophagus: 94.1284% (minimum 97%, Missing); heart muscle: 93.6131% (minimum 95%, Enhanced); hippocampal formation: 96.0674% (minimum 99%, Missing); hypothalamus: 96.0674% (minimum 99%, Missing); kidney: 94.6494% (minimum 95%, Enhanced); lung: 94.3015% (minimum 95%, Enhanced); lymph node: 94.6494% (minimum 97%, Missing); midbrain: 96.7925% (minimum 99%, Missing); pancreas: 93.6131% (minimum 95%, Enhanced); pituitary gland: 96.6102% (minimum 99%, Missing); rectum: 96.4286% (minimum 97%, Missing); retina: 98.4645% (minimum 99%, Missing); skeletal muscle: 85.7860% (minimum 95%, Enhanced); small intestine: 92.4324% (minimum 99%, Missing); spinal cord: 97.1591% (minimum 99%, Missing); stomach: 93.2727% (minimum 97%, Missing); thymus: 93.4426% (minimum 95%, Missing); tongue: 96.7925% (minimum 97%, Missing); urinary bladder: 93.1034% (minimum 97%, Missing)",0,1,partial,8.5,3.8,4.7,"skeletal muscle: 8.5 nTPM (vital, limit 6); small intestine: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); urinary bladder: 3.8 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000064703,DDX20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0155738,-0.0389655,-0.0921405
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,9.1,4.7,7.9,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000065328,MCM10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.2381% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 18.0180% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.9091% (minimum 99%, Baseline (adaptation disabled)); colon: 54.0541% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.1429% (minimum 99%, Baseline (adaptation disabled)); esophagus: 51.2821% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.2381% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.2381% (minimum 99%, Baseline (adaptation disabled)); liver: 74.0741% (minimum 99%, Baseline (adaptation disabled)); lung: 86.9565% (minimum 99%, Baseline (adaptation disabled)); lymph node: 29.8507% (minimum 97%, Baseline (adaptation disabled)); pancreas: 95.2381% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.2381% (minimum 99%, Baseline (adaptation disabled)); rectum: 48.7805% (minimum 97%, Baseline (adaptation disabled)); retina: 95.2381% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 86.9565% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 64.5161% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.9655% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.4286% (minimum 97%, Baseline (adaptation disabled)); thymus: 20.2020% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.9565% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.2381% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.9231% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,9.1,4.7,7.9,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000065328,MCM10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.74798,-0.671493,-0.80982
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 90%, Approved); adrenal gland: 95.2381% (minimum 98%, Approved); bone marrow: 18.0180% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 98%, Approved); colon: 54.0541% (minimum 95%, Approved); duodenum: 57.1429% (minimum 98%, Approved); esophagus: 51.2821% (minimum 95%, Approved); heart muscle: 95.2381% (minimum 98%, Approved); hypothalamus: 95.2381% (minimum 99%, Missing); kidney: 95.2381% (minimum 98%, Approved); liver: 74.0741% (minimum 98%, Approved); lung: 86.9565% (minimum 98%, Approved); lymph node: 29.8507% (minimum 97%, Missing); pancreas: 95.2381% (minimum 98%, Approved); parathyroid gland: 90.9091% (minimum 95%, Approved); pituitary gland: 95.2381% (minimum 99%, Missing); rectum: 48.7805% (minimum 95%, Approved); retina: 95.2381% (minimum 99%, Missing); salivary gland: 86.9565% (minimum 95%, Approved); skeletal muscle: 80.0000% (minimum 98%, Approved); skin: 64.5161% (minimum 90%, Approved); small intestine: 62.5000% (minimum 98%, Approved); smooth muscle: 71.4286% (minimum 98%, Approved); spleen: 68.9655% (minimum 95%, Missing); stomach: 71.4286% (minimum 95%, Approved); thymus: 20.2020% (minimum 95%, Missing); thyroid gland: 86.9565% (minimum 90%, Approved); tongue: 95.2381% (minimum 97%, Missing); urinary bladder: 76.9231% (minimum 95%, Approved)",0,0,routine_complete,9.1,4.7,7.9,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000065328,MCM10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.74798,-0.671493,-0.80982
True,compatible,,True,True,False,,0,3,partial,0.6,6,1.5,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000065371,ROPN1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 96.2594% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,0.6,6,1.5,"salivary gland: 6 nTPM (protected, limit 2)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000065371,ROPN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0403784,-0.00740648,0.00612903
True,compatible,,True,True,True,,0,3,partial,0.6,6,1.5,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000065371,ROPN1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.0267721,0.00806076
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,110.6,2.9,1.3,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 6)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000065609,SNAP91,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.8247% (minimum 99%, Baseline (adaptation disabled)); amygdala: 22.4762% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 28.1623% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 9.6405% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 11.6832% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 54.1284% (minimum 99%, Baseline (adaptation disabled)); colon: 90.7692% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.5207% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.4000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 21.3382% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 20.3098% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5207% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.2721% (minimum 97%, Baseline (adaptation disabled)); midbrain: 28.3654% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.7218% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.4729% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 31.9783% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.1613% (minimum 97%, Baseline (adaptation disabled)); retina: 11.7063% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.9350% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.3333% (minimum 99%, Baseline (adaptation disabled)); small intestine: 93.6508% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.4000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 38.9439% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.0763% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.6508% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.9134% (minimum 95%, Baseline (adaptation disabled)); tongue: 89.3939% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.7213% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,110.6,2.9,1.3,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000065609,SNAP91,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0492366,-0.167279,-0.893595
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.8247% (minimum 95%, Enhanced); amygdala: 22.4762% (minimum 99%, Missing); basal ganglia: 28.1623% (minimum 99%, Missing); cerebellum: 9.6405% (minimum 99%, Missing); cerebral cortex: 11.6832% (minimum 99%, Missing); choroid plexus: 54.1284% (minimum 99%, Missing); colon: 90.7692% (minimum 97%, Missing); heart muscle: 94.4000% (minimum 95%, Enhanced); hippocampal formation: 21.3382% (minimum 99%, Missing); hypothalamus: 20.3098% (minimum 99%, Missing); midbrain: 28.3654% (minimum 99%, Missing); pancreas: 88.7218% (minimum 95%, Enhanced); pituitary gland: 31.9783% (minimum 99%, Missing); retina: 11.7063% (minimum 99%, Missing); small intestine: 93.6508% (minimum 95%, Enhanced); smooth muscle: 94.4000% (minimum 95%, Enhanced); spinal cord: 38.9439% (minimum 99%, Missing); tongue: 89.3939% (minimum 97%, Missing)",0,5,partial,110.6,2.9,1.3,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 6)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000065609,SNAP91,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0252066,-0.0760606,-0.893595
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,27.3,19.4,18.7,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 2); thyroid gland: 18.7 nTPM (manageable, limit 5); retina: 18.4 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); spleen: 15.5 nTPM (manageable, limit 5); parathyroid gland: 15.1 nTPM (protected, limit 2); liver: 14.7 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 2); esophagus: 12.5 nTPM (protected, limit 2); rectum: 12.1 nTPM (protected, limit 2); stomach: 11.7 nTPM (protected, limit 2); cerebellum: 11.6 nTPM (vital, limit 1); pancreas: 11.6 nTPM (vital, limit 1); kidney: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); urinary bladder: 11.4 nTPM (protected, limit 2); skin: 11.3 nTPM (manageable, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 2); lung: 10.8 nTPM (vital, limit 1); skeletal muscle: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10 nTPM (manageable, limit 5); duodenum: 10 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000065883,CDK13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.0996% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.5172% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.3756% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.6725% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.5135% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 59.5819% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.5688% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.4000% (minimum 99%, Baseline (adaptation disabled)); colon: 60.6383% (minimum 97%, Baseline (adaptation disabled)); duodenum: 63.0996% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.7703% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.2672% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.3393% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.5819% (minimum 99%, Baseline (adaptation disabled)); liver: 53.7736% (minimum 99%, Baseline (adaptation disabled)); lung: 61.2903% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.8493% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.7273% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.5819% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 53.1056% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.9516% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.5616% (minimum 97%, Baseline (adaptation disabled)); retina: 48.1690% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.7902% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.2903% (minimum 99%, Baseline (adaptation disabled)); skin: 60.2113% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.4240% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.7329% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.4540% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.3750% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.4425% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 47.7654% (minimum 95%, Baseline (adaptation disabled)); tongue: 57.5758% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,27.3,19.4,18.7,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 2); thyroid gland: 18.7 nTPM (manageable, limit 5); retina: 18.4 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); spleen: 15.5 nTPM (manageable, limit 5); parathyroid gland: 15.1 nTPM (protected, limit 2); liver: 14.7 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 2); esophagus: 12.5 nTPM (protected, limit 2); rectum: 12.1 nTPM (protected, limit 2); stomach: 11.7 nTPM (protected, limit 2); cerebellum: 11.6 nTPM (vital, limit 1); pancreas: 11.6 nTPM (vital, limit 1); kidney: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); urinary bladder: 11.4 nTPM (protected, limit 2); skin: 11.3 nTPM (manageable, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 2); lung: 10.8 nTPM (vital, limit 1); skeletal muscle: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10 nTPM (manageable, limit 5); duodenum: 10 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000065883,CDK13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.472346,-0.501507,-0.604865
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.0996% (minimum 95%, Uncertain); adrenal gland: 65.5172% (minimum 99%, Uncertain); amygdala: 77.3756% (minimum 99%, Missing); basal ganglia: 74.6725% (minimum 99%, Missing); bone marrow: 38.5135% (minimum 99%, Uncertain); cerebellum: 59.5819% (minimum 99%, Uncertain); cerebral cortex: 63.5688% (minimum 99%, Uncertain); choroid plexus: 68.4000% (minimum 99%, Missing); colon: 60.6383% (minimum 97%, Uncertain); duodenum: 63.0996% (minimum 99%, Missing); esophagus: 57.7703% (minimum 97%, Missing); heart muscle: 65.2672% (minimum 99%, Missing); hippocampal formation: 76.3393% (minimum 99%, Missing); hypothalamus: 76.0000% (minimum 99%, Missing); kidney: 59.5819% (minimum 99%, Missing); liver: 53.7736% (minimum 99%, Uncertain); lung: 61.2903% (minimum 99%, Uncertain); lymph node: 46.8493% (minimum 97%, Uncertain); midbrain: 77.7273% (minimum 99%, Missing); pancreas: 59.5819% (minimum 99%, Uncertain); parathyroid gland: 53.1056% (minimum 97%, Missing); pituitary gland: 68.9516% (minimum 99%, Missing); rectum: 58.5616% (minimum 97%, Missing); retina: 48.1690% (minimum 99%, Missing); salivary gland: 59.7902% (minimum 97%, Uncertain); skeletal muscle: 61.2903% (minimum 99%, Uncertain); skin: 60.2113% (minimum 95%, Missing); small intestine: 60.4240% (minimum 99%, Missing); smooth muscle: 61.7329% (minimum 99%, Uncertain); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 52.4540% (minimum 95%, Uncertain); stomach: 59.3750% (minimum 97%, Missing); thymus: 50.4425% (minimum 95%, Missing); thyroid gland: 47.7654% (minimum 95%, Uncertain); tongue: 57.5758% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",0,2,partial,27.3,19.4,18.7,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 2); thyroid gland: 18.7 nTPM (manageable, limit 5); retina: 18.4 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); spleen: 15.5 nTPM (manageable, limit 5); parathyroid gland: 15.1 nTPM (protected, limit 2); liver: 14.7 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 2); esophagus: 12.5 nTPM (protected, limit 2); rectum: 12.1 nTPM (protected, limit 2); stomach: 11.7 nTPM (protected, limit 2); cerebellum: 11.6 nTPM (vital, limit 1); pancreas: 11.6 nTPM (vital, limit 1); kidney: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); urinary bladder: 11.4 nTPM (protected, limit 2); skin: 11.3 nTPM (manageable, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 2); lung: 10.8 nTPM (vital, limit 1); skeletal muscle: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10 nTPM (manageable, limit 5); duodenum: 10 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000065883,CDK13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.472346,-0.501507,-0.604865
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,91.6,1.9,0.1,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 6); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000066032,CTNNA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.4379% (minimum 99%, Baseline (adaptation disabled)); amygdala: 44.2867% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 52.0254% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.2986% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 41.6932% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.9722% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 53.9539% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.1021% (minimum 99%, Baseline (adaptation disabled)); midbrain: 68.6583% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.7934% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.4696% (minimum 99%, Baseline (adaptation disabled)); retina: 45.6446% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9426% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.9580% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,91.6,1.9,0.1,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000066032,CTNNA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0484756,0.00181009,-0.573068
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.4379% (minimum 95%, Enhanced); amygdala: 44.2867% (minimum 99%, Missing); basal ganglia: 52.0254% (minimum 99%, Missing); cerebellum: 84.2986% (minimum 95%, Enhanced); cerebral cortex: 41.6932% (minimum 99%, Missing); choroid plexus: 90.9722% (minimum 99%, Missing); hippocampal formation: 53.9539% (minimum 99%, Missing); hypothalamus: 63.1021% (minimum 99%, Missing); midbrain: 68.6583% (minimum 99%, Missing); pituitary gland: 90.4696% (minimum 99%, Missing); retina: 45.6446% (minimum 99%, Missing); spinal cord: 85.9580% (minimum 99%, Missing)",0,3,partial,91.6,1.9,0.1,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 6); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000066032,CTNNA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,0.03,-0.573068
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.9,2.4,4.8,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000066185,ZMYND12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.6910% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.2913% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.4608% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.5524% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.7763% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.8095% (minimum 99%, Baseline (adaptation disabled)); colon: 96.2069% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.5398% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 92.6910% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.8795% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.6460% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.6098% (minimum 99%, Baseline (adaptation disabled)); liver: 80.6358% (minimum 99%, Baseline (adaptation disabled)); lung: 93.6242% (minimum 99%, Baseline (adaptation disabled)); midbrain: 89.1374% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.7106% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.6910% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 89.4231% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.2069% (minimum 97%, Baseline (adaptation disabled)); retina: 87.7358% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.5398% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.9394% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5866% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.2125% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.5844% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.5763% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 85.3211% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.0792% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.8750% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.9,2.4,4.8,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000066185,ZMYND12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.096789,-0.0492079,-0.251905
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.6910% (minimum 99%, Missing); amygdala: 90.2913% (minimum 99%, Missing); basal ganglia: 87.4608% (minimum 99%, Missing); cerebellum: 97.5524% (minimum 99%, Missing); cerebral cortex: 91.7763% (minimum 99%, Missing); choroid plexus: 73.8095% (minimum 99%, Missing); colon: 96.2069% (minimum 97%, Missing); duodenum: 96.5398% (minimum 99%, Missing); heart muscle: 92.6910% (minimum 99%, Missing); hippocampal formation: 90.8795% (minimum 99%, Missing); hypothalamus: 86.6460% (minimum 99%, Missing); kidney: 75.6098% (minimum 99%, Missing); liver: 80.6358% (minimum 99%, Missing); lung: 93.6242% (minimum 99%, Missing); midbrain: 89.1374% (minimum 99%, Missing); pancreas: 89.7106% (minimum 99%, Missing); parathyroid gland: 92.6910% (minimum 97%, Missing); pituitary gland: 89.4231% (minimum 99%, Missing); rectum: 96.2069% (minimum 97%, Missing); retina: 87.7358% (minimum 99%, Missing); salivary gland: 96.5398% (minimum 97%, Missing); skeletal muscle: 93.9394% (minimum 99%, Missing); small intestine: 98.5866% (minimum 99%, Missing); smooth muscle: 97.2125% (minimum 99%, Missing); spinal cord: 90.5844% (minimum 99%, Missing); stomach: 94.5763% (minimum 97%, Missing); thyroid gland: 85.3211% (minimum 95%, Missing); tongue: 92.0792% (minimum 97%, Missing); urinary bladder: 96.8750% (minimum 97%, Missing)",0,80,unavailable,9.9,2.4,4.8,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000066185,ZMYND12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.096789,-0.0492079,-0.251905
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10,5.1,16.5,"thymus: 16.5 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000066279,ASPM,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.9394% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 23.6641% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.8750% (minimum 99%, Baseline (adaptation disabled)); colon: 65.9574% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.7843% (minimum 99%, Baseline (adaptation disabled)); esophagus: 67.3913% (minimum 97%, Baseline (adaptation disabled)); liver: 83.7838% (minimum 99%, Baseline (adaptation disabled)); lung: 91.1765% (minimum 99%, Baseline (adaptation disabled)); lymph node: 37.8049% (minimum 97%, Baseline (adaptation disabled)); rectum: 63.2653% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 93.9394% (minimum 97%, Baseline (adaptation disabled)); skin: 54.3860% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.2653% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.7838% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.9394% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.8095% (minimum 97%, Baseline (adaptation disabled)); thymus: 15.8163% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 83.7838% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10,5.1,16.5,"thymus: 16.5 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000066279,ASPM,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.791837,-0.591951,-0.753359
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.9394% (minimum 95%, Missing); bone marrow: 23.6641% (minimum 99%, Missing); cerebral cortex: 96.8750% (minimum 99%, Missing); colon: 65.9574% (minimum 97%, Missing); duodenum: 60.7843% (minimum 99%, Missing); esophagus: 67.3913% (minimum 97%, Missing); liver: 83.7838% (minimum 99%, Missing); lung: 91.1765% (minimum 99%, Missing); lymph node: 37.8049% (minimum 97%, Missing); rectum: 63.2653% (minimum 97%, Missing); salivary gland: 93.9394% (minimum 97%, Missing); skin: 54.3860% (minimum 95%, Missing); small intestine: 63.2653% (minimum 99%, Missing); smooth muscle: 83.7838% (minimum 99%, Missing); spinal cord: 93.9394% (minimum 99%, Missing); spleen: 77.5000% (minimum 95%, Missing); stomach: 73.8095% (minimum 97%, Missing); thymus: 15.8163% (minimum 95%, Missing); urinary bladder: 83.7838% (minimum 97%, Missing)",0,80,unavailable,10,5.1,16.5,"thymus: 16.5 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000066279,ASPM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.791837,-0.591951,-0.753359
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,3,partial,1.1,0.4,0.5,,heart muscle / cardiomyocytes: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000066923,STAG3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 97.9167% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2890% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.1,0.4,0.5,"bone marrow: 1.1 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000066923,STAG3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0404215,0.0223225,-0.0108333
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"heart muscle: 98.2890% (minimum 99%, Missing)",0,3,partial,1.1,0.4,0.5,,heart muscle / cardiomyocytes: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000066923,STAG3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0404215,0.0280695,-0.00711027
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,7.9,7.1,2.7,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 2); rectum: 4.9 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000067646,ZFY,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.9167% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.3953% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.3529% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 46.9799% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.7071% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.6517% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.1053% (minimum 99%, Baseline (adaptation disabled)); colon: 76.0870% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.9167% (minimum 99%, Baseline (adaptation disabled)); esophagus: 61.4035% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.5455% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.3529% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.4598% (minimum 99%, Baseline (adaptation disabled)); liver: 61.9469% (minimum 99%, Baseline (adaptation disabled)); lung: 80.4598% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.3659% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.6842% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.6517% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.3529% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.8235% (minimum 97%, Baseline (adaptation disabled)); retina: 76.0870% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.9167% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 67.9612% (minimum 99%, Baseline (adaptation disabled)); skin: 80.4598% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.0631% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.3953% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.9231% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.4681% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 72.1649% (minimum 95%, Baseline (adaptation disabled)); tongue: 49.6454% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.3069% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,7.9,7.1,2.7,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 2); rectum: 4.9 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000067646,ZFY,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.228351,-0.473546,-0.520201
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.9167% (minimum 95%, Uncertain); adrenal gland: 81.3953% (minimum 99%, Uncertain); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 82.3529% (minimum 99%, Missing); bone marrow: 46.9799% (minimum 99%, Missing); cerebellum: 70.7071% (minimum 99%, Missing); cerebral cortex: 78.6517% (minimum 99%, Missing); choroid plexus: 92.1053% (minimum 99%, Missing); colon: 76.0870% (minimum 97%, Missing); duodenum: 72.9167% (minimum 99%, Missing); esophagus: 61.4035% (minimum 97%, Uncertain); heart muscle: 79.5455% (minimum 99%, Uncertain); hippocampal formation: 82.3529% (minimum 99%, Missing); hypothalamus: 83.3333% (minimum 99%, Missing); kidney: 80.4598% (minimum 99%, Missing); liver: 61.9469% (minimum 99%, Missing); lung: 80.4598% (minimum 99%, Missing); lymph node: 85.3659% (minimum 97%, Missing); midbrain: 83.3333% (minimum 99%, Missing); pancreas: 73.6842% (minimum 99%, Missing); parathyroid gland: 78.6517% (minimum 97%, Missing); pituitary gland: 82.3529% (minimum 99%, Missing); rectum: 58.8235% (minimum 97%, Missing); retina: 76.0870% (minimum 99%, Missing); salivary gland: 72.9167% (minimum 97%, Missing); skeletal muscle: 67.9612% (minimum 99%, Missing); skin: 80.4598% (minimum 95%, Missing); small intestine: 63.0631% (minimum 99%, Missing); spinal cord: 81.3953% (minimum 99%, Missing); spleen: 76.9231% (minimum 95%, Missing); stomach: 74.4681% (minimum 97%, Missing); thyroid gland: 72.1649% (minimum 95%, Missing); tongue: 49.6454% (minimum 97%, Missing); urinary bladder: 69.3069% (minimum 97%, Missing)",0,4,partial,7.9,7.1,2.7,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 2); rectum: 4.9 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000067646,ZFY,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.228351,-0.473546,-0.520201
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,17.8,10,20,"thymus: 20 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); small intestine: 4.8 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000068489,PRR11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.9259% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.2340% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.1818% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.1818% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 18.7215% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.6190% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.4915% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.1304% (minimum 99%, Baseline (adaptation disabled)); colon: 47.6744% (minimum 97%, Baseline (adaptation disabled)); duodenum: 39.4231% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.2468% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.3922% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.1111% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.1818% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.2340% (minimum 99%, Baseline (adaptation disabled)); liver: 75.9259% (minimum 99%, Baseline (adaptation disabled)); lung: 65.0794% (minimum 99%, Baseline (adaptation disabled)); lymph node: 29.0780% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.1111% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.1304% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.1818% (minimum 97%, Baseline (adaptation disabled)); rectum: 43.6170% (minimum 97%, Baseline (adaptation disabled)); retina: 71.9298% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.1304% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.8462% (minimum 99%, Baseline (adaptation disabled)); skin: 57.7465% (minimum 95%, Baseline (adaptation disabled)); small intestine: 46.0674% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.9474% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.6735% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.9444% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.0794% (minimum 97%, Baseline (adaptation disabled)); thymus: 17.0124% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 77.3585% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.1111% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.2131% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,17.8,10,20,"thymus: 20 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); small intestine: 4.8 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000068489,PRR11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.779876,-0.67922,-0.802785
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.9259% (minimum 95%, Missing); adrenal gland: 87.2340% (minimum 99%, Missing); amygdala: 93.1818% (minimum 99%, Missing); basal ganglia: 93.1818% (minimum 99%, Missing); bone marrow: 18.7215% (minimum 99%, Missing); cerebellum: 97.6190% (minimum 99%, Missing); cerebral cortex: 69.4915% (minimum 99%, Missing); choroid plexus: 89.1304% (minimum 99%, Missing); colon: 47.6744% (minimum 97%, Missing); duodenum: 39.4231% (minimum 99%, Missing); esophagus: 53.2468% (minimum 97%, Missing); heart muscle: 80.3922% (minimum 99%, Missing); hippocampal formation: 91.1111% (minimum 99%, Missing); hypothalamus: 93.1818% (minimum 99%, Missing); kidney: 87.2340% (minimum 99%, Missing); liver: 75.9259% (minimum 99%, Missing); lung: 65.0794% (minimum 99%, Missing); lymph node: 29.0780% (minimum 97%, Missing); midbrain: 91.1111% (minimum 99%, Missing); pancreas: 89.1304% (minimum 99%, Missing); parathyroid gland: 93.1818% (minimum 97%, Missing); rectum: 43.6170% (minimum 97%, Missing); retina: 71.9298% (minimum 99%, Missing); salivary gland: 89.1304% (minimum 97%, Missing); skeletal muscle: 78.8462% (minimum 99%, Missing); skin: 57.7465% (minimum 95%, Missing); small intestine: 46.0674% (minimum 99%, Missing); smooth muscle: 53.9474% (minimum 99%, Missing); spinal cord: 83.6735% (minimum 99%, Missing); spleen: 56.9444% (minimum 95%, Missing); stomach: 65.0794% (minimum 97%, Missing); thymus: 17.0124% (minimum 95%, Missing); thyroid gland: 77.3585% (minimum 95%, Missing); tongue: 91.1111% (minimum 97%, Missing); urinary bladder: 67.2131% (minimum 97%, Missing)",0,80,unavailable,17.8,10,20,"thymus: 20 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); small intestine: 4.8 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000068489,PRR11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.779876,-0.67922,-0.802785
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,41.4,32.1,42.4,"thymus: 42.4 nTPM (manageable, limit 5); retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 2); urinary bladder: 19.5 nTPM (protected, limit 2); spleen: 18 nTPM (manageable, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 2); colon: 13.3 nTPM (protected, limit 2); smooth muscle: 12.6 nTPM (vital, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); thyroid gland: 12.2 nTPM (manageable, limit 10); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 2); parathyroid gland: 11.9 nTPM (protected, limit 2); adipose tissue: 11.5 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 2); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 2); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 4); tongue: 6.5 nTPM (protected, limit 2); heart muscle: 6 nTPM (vital, limit 2); skin: 5.7 nTPM (manageable, limit 5); liver: 5.2 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000068796,KIF2A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.5743% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.4130% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.6327% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.1045% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.3309% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.9212% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.3626% (minimum 99%, Baseline (adaptation disabled)); colon: 78.1967% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.1224% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.7659% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.8268% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.2366% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.4423% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.9459% (minimum 99%, Baseline (adaptation disabled)); liver: 90.1701% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3916% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.7744% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.8125% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.0336% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.1786% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.0598% (minimum 97%, Baseline (adaptation disabled)); retina: 53.5354% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.6838% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.2046% (minimum 99%, Baseline (adaptation disabled)); skin: 89.3258% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.4747% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 79.1045% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.3846% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.6027% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.6842% (minimum 97%, Baseline (adaptation disabled)); thymus: 52.9412% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 79.6327% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.0074% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 70.9821% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,41.4,32.1,42.4,"thymus: 42.4 nTPM (manageable, limit 5); retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 2); urinary bladder: 19.5 nTPM (protected, limit 2); spleen: 18 nTPM (manageable, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 2); colon: 13.3 nTPM (protected, limit 2); smooth muscle: 12.6 nTPM (vital, limit 1); bone marrow: 12.6 nTPM (vital, limit 1); thyroid gland: 12.2 nTPM (manageable, limit 5); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 2); parathyroid gland: 11.9 nTPM (protected, limit 2); adipose tissue: 11.5 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 2); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); tongue: 6.5 nTPM (protected, limit 2); heart muscle: 6 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); liver: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000068796,KIF2A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.420588,-0.372256,-0.454646
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.5743% (minimum 95%, Missing); adrenal gland: 86.4130% (minimum 99%, Missing); amygdala: 75.7143% (minimum 99%, Missing); basal ganglia: 79.6327% (minimum 99%, Missing); bone marrow: 79.1045% (minimum 99%, Missing); cerebellum: 85.3309% (minimum 99%, Missing); cerebral cortex: 56.9212% (minimum 99%, Missing); choroid plexus: 87.3626% (minimum 99%, Missing); colon: 78.1967% (minimum 97%, Missing); duodenum: 81.1224% (minimum 99%, Missing); esophagus: 79.7659% (minimum 97%, Missing); heart muscle: 88.8268% (minimum 98%, Approved); hippocampal formation: 75.2366% (minimum 99%, Missing); hypothalamus: 76.4423% (minimum 99%, Missing); kidney: 85.9459% (minimum 98%, Approved); liver: 90.1701% (minimum 98%, Approved); lung: 83.3916% (minimum 99%, Missing); lymph node: 59.7744% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 82.8125% (minimum 99%, Missing); parathyroid gland: 80.0336% (minimum 97%, Missing); pituitary gland: 85.1786% (minimum 99%, Missing); rectum: 77.0598% (minimum 97%, Missing); retina: 53.5354% (minimum 99%, Missing); salivary gland: 87.6838% (minimum 95%, Approved); skeletal muscle: 91.2046% (minimum 98%, Approved); skin: 89.3258% (minimum 95%, Missing); small intestine: 75.4747% (minimum 99%, Missing); smooth muscle: 79.1045% (minimum 98%, Approved); spinal cord: 73.3846% (minimum 99%, Missing); spleen: 72.6027% (minimum 95%, Missing); stomach: 83.6842% (minimum 97%, Missing); thymus: 52.9412% (minimum 95%, Missing); thyroid gland: 79.6327% (minimum 90%, Approved); tongue: 88.0074% (minimum 97%, Missing); urinary bladder: 70.9821% (minimum 97%, Missing)",0,4,partial,41.4,32.1,42.4,"thymus: 42.4 nTPM (manageable, limit 5); retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 2); urinary bladder: 19.5 nTPM (protected, limit 2); spleen: 18 nTPM (manageable, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 2); colon: 13.3 nTPM (protected, limit 2); smooth muscle: 12.6 nTPM (vital, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); thyroid gland: 12.2 nTPM (manageable, limit 10); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 2); parathyroid gland: 11.9 nTPM (protected, limit 2); adipose tissue: 11.5 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 2); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 2); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 4); tongue: 6.5 nTPM (protected, limit 2); heart muscle: 6 nTPM (vital, limit 2); skin: 5.7 nTPM (manageable, limit 5); liver: 5.2 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000068796,KIF2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.420588,-0.372256,-0.454646
True,compatible,,True,True,False,,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000068985,PAGE1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000068985,PAGE1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000068985,PAGE1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.2,1.1,2.6,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000069188,SDK2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.9495% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.0370% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.0693% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.9167% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.9286% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.9167% (minimum 99%, Baseline (adaptation disabled)); colon: 94.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.9474% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.2621% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.6792% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.4561% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.9072% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9474% (minimum 99%, Baseline (adaptation disabled)); lung: 89.5238% (minimum 99%, Baseline (adaptation disabled)); lymph node: 89.5238% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.3846% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.9474% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.2621% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.8505% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.9072% (minimum 97%, Baseline (adaptation disabled)); retina: 91.2621% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.9167% (minimum 99%, Baseline (adaptation disabled)); skin: 94.9495% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.1569% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.9167% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.0345% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.9495% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.0693% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.8505% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.9072% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.9184% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.2,1.1,2.6,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000069188,SDK2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.166667,-0.0747619,-0.179655
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.9495% (minimum 99%, Missing); amygdala: 87.0370% (minimum 99%, Missing); basal ganglia: 93.0693% (minimum 99%, Missing); bone marrow: 94.0000% (minimum 99%, Missing); cerebellum: 97.9167% (minimum 99%, Missing); cerebral cortex: 83.9286% (minimum 99%, Missing); choroid plexus: 97.9167% (minimum 99%, Missing); colon: 94.0000% (minimum 97%, Missing); duodenum: 98.9474% (minimum 99%, Missing); esophagus: 94.0000% (minimum 97%, Missing); heart muscle: 91.2621% (minimum 99%, Missing); hippocampal formation: 88.6792% (minimum 99%, Missing); hypothalamus: 82.4561% (minimum 99%, Missing); kidney: 96.9072% (minimum 99%, Missing); liver: 98.9474% (minimum 99%, Missing); lung: 89.5238% (minimum 99%, Missing); lymph node: 89.5238% (minimum 97%, Missing); midbrain: 90.3846% (minimum 99%, Missing); pancreas: 98.9474% (minimum 99%, Missing); parathyroid gland: 91.2621% (minimum 97%, Missing); pituitary gland: 87.8505% (minimum 99%, Missing); rectum: 96.9072% (minimum 97%, Missing); retina: 91.2621% (minimum 99%, Missing); salivary gland: 94.0000% (minimum 97%, Missing); skeletal muscle: 97.9167% (minimum 99%, Missing); skin: 94.9495% (minimum 95%, Missing); small intestine: 92.1569% (minimum 99%, Missing); smooth muscle: 97.9167% (minimum 99%, Missing); spinal cord: 81.0345% (minimum 99%, Missing); spleen: 78.3333% (minimum 95%, Missing); stomach: 94.9495% (minimum 97%, Missing); thymus: 93.0693% (minimum 95%, Missing); thyroid gland: 87.8505% (minimum 95%, Missing); tongue: 96.9072% (minimum 97%, Missing); urinary bladder: 95.9184% (minimum 97%, Missing)",0,80,unavailable,2.2,1.1,2.6,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000069188,SDK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.166667,-0.0747619,-0.179655
True,compatible,,True,True,False,,0,0,routine_complete,0.6,0,0,,,53,not_established,not_triggered,,,ENSG00000069206,ADAM7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,0,routine_complete,0.6,0,0,,,53,not_established,not_triggered,,,ENSG00000069206,ADAM7,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00983512
True,compatible,,True,True,True,,0,0,routine_complete,0.6,0,0,,,53,not_established,not_triggered,,,ENSG00000069206,ADAM7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,19.8,52.7,30.9,"lymph node: 52.7 nTPM (protected, limit 2); thymus: 30.9 nTPM (manageable, limit 5); spleen: 26 nTPM (manageable, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000069493,CLEC2D,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.4033% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.1429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.1429% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.7698% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 42.5087% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.5736% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.7059% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.9394% (minimum 99%, Baseline (adaptation disabled)); colon: 72.6190% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.2500% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.7386% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.5202% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.9155% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.9155% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.2500% (minimum 99%, Baseline (adaptation disabled)); liver: 79.2208% (minimum 99%, Baseline (adaptation disabled)); lung: 59.5122% (minimum 99%, Baseline (adaptation disabled)); lymph node: 18.7982% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.9932% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.1379% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.8462% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.7222% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.7764% (minimum 97%, Baseline (adaptation disabled)); retina: 77.7070% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.5914% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 79.7386% (minimum 99%, Baseline (adaptation disabled)); skin: 76.7296% (minimum 95%, Baseline (adaptation disabled)); small intestine: 38.1250% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.3147% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.7097% (minimum 99%, Baseline (adaptation disabled)); spleen: 31.9372% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.3182% (minimum 97%, Baseline (adaptation disabled)); thymus: 28.3063% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 73.9394% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.3704% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.5393% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,19.8,52.7,30.9,"lymph node: 52.7 nTPM (protected, limit 2); thymus: 30.9 nTPM (manageable, limit 5); spleen: 26 nTPM (manageable, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000069493,CLEC2D,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.666937,-0.782018,-0.60875
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.4033% (minimum 95%, Uncertain); adrenal gland: 87.1429% (minimum 99%, Missing); amygdala: 87.1429% (minimum 99%, Missing); basal ganglia: 87.7698% (minimum 99%, Missing); bone marrow: 42.5087% (minimum 99%, Missing); cerebellum: 94.5736% (minimum 99%, Missing); cerebral cortex: 89.7059% (minimum 99%, Missing); choroid plexus: 73.9394% (minimum 99%, Missing); colon: 72.6190% (minimum 97%, Missing); duodenum: 76.2500% (minimum 99%, Missing); esophagus: 79.7386% (minimum 97%, Missing); heart muscle: 70.5202% (minimum 99%, Missing); hippocampal formation: 85.9155% (minimum 99%, Missing); hypothalamus: 85.9155% (minimum 99%, Missing); kidney: 76.2500% (minimum 99%, Missing); liver: 79.2208% (minimum 99%, Missing); lung: 59.5122% (minimum 99%, Missing); lymph node: 18.7982% (minimum 97%, Missing); midbrain: 82.9932% (minimum 99%, Missing); pancreas: 84.1379% (minimum 99%, Missing); parathyroid gland: 93.8462% (minimum 97%, Missing); pituitary gland: 84.7222% (minimum 99%, Missing); rectum: 75.7764% (minimum 97%, Missing); retina: 77.7070% (minimum 99%, Missing); salivary gland: 65.5914% (minimum 97%, Missing); skeletal muscle: 79.7386% (minimum 99%, Missing); skin: 76.7296% (minimum 95%, Missing); small intestine: 38.1250% (minimum 99%, Missing); smooth muscle: 85.3147% (minimum 99%, Missing); spinal cord: 78.7097% (minimum 99%, Missing); spleen: 31.9372% (minimum 95%, Missing); stomach: 69.3182% (minimum 97%, Missing); thymus: 28.3063% (minimum 95%, Missing); thyroid gland: 73.9394% (minimum 95%, Missing); tongue: 90.3704% (minimum 97%, Missing); urinary bladder: 68.5393% (minimum 97%, Missing)",0,2,partial,19.8,52.7,30.9,"lymph node: 52.7 nTPM (protected, limit 2); thymus: 30.9 nTPM (manageable, limit 5); spleen: 26 nTPM (manageable, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000069493,CLEC2D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.666937,-0.782018,-0.60875
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,66.8,3.9,6.1,"retina: 66.8 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000070601,FRMPD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.7917% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.7273% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.5310% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.9192% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.4862% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 94.7917% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.8571% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.8491% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.3495% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.2157% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.7917% (minimum 99%, Baseline (adaptation disabled)); liver: 94.7917% (minimum 99%, Baseline (adaptation disabled)); lung: 93.8144% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.4862% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.9192% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.8571% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.8571% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.7917% (minimum 97%, Baseline (adaptation disabled)); retina: 11.9895% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.4656% (minimum 99%, Baseline (adaptation disabled)); skin: 59.8684% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.2157% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.7895% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.8571% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.7917% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 90.0990% (minimum 95%, Baseline (adaptation disabled)); tongue: 89.2157% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.7917% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,66.8,3.9,6.1,"retina: 66.8 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000070601,FRMPD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.351316,-0.27,-0.870105
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.7917% (minimum 99%, Missing); amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 82.7273% (minimum 99%, Missing); bone marrow: 80.5310% (minimum 99%, Missing); cerebellum: 91.9192% (minimum 99%, Missing); cerebral cortex: 83.4862% (minimum 99%, Missing); choroid plexus: 91.0000% (minimum 99%, Missing); colon: 94.7917% (minimum 97%, Missing); duodenum: 92.8571% (minimum 99%, Missing); esophagus: 85.8491% (minimum 97%, Missing); heart muscle: 92.8571% (minimum 99%, Missing); hippocampal formation: 88.3495% (minimum 99%, Missing); hypothalamus: 89.2157% (minimum 99%, Missing); kidney: 94.7917% (minimum 99%, Missing); liver: 94.7917% (minimum 99%, Missing); lung: 93.8144% (minimum 99%, Missing); lymph node: 87.5000% (minimum 97%, Missing); midbrain: 83.4862% (minimum 99%, Missing); pancreas: 91.9192% (minimum 99%, Missing); parathyroid gland: 92.8571% (minimum 97%, Missing); pituitary gland: 92.8571% (minimum 99%, Missing); rectum: 94.7917% (minimum 97%, Missing); retina: 11.9895% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 69.4656% (minimum 99%, Missing); skin: 59.8684% (minimum 95%, Missing); small intestine: 89.2157% (minimum 99%, Missing); smooth muscle: 95.7895% (minimum 99%, Missing); spinal cord: 92.8571% (minimum 99%, Missing); stomach: 94.7917% (minimum 97%, Missing); thyroid gland: 90.0990% (minimum 95%, Missing); tongue: 89.2157% (minimum 97%, Missing); urinary bladder: 94.7917% (minimum 97%, Uncertain)",0,2,partial,66.8,3.9,6.1,"retina: 66.8 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000070601,FRMPD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.351316,-0.27,-0.870105
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,32.4,0,4.5,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000070886,EPHA8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.1818% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.7419% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 63.6364% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.6250% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.8462% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 6.0870% (minimum 99%, Baseline (adaptation disabled)); duodenum: 77.7778% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.4138% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 43.7500% (minimum 99%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 39.6226% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 58.3333% (minimum 99%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.4138% (minimum 99%, Baseline (adaptation disabled)); spleen: 31.8182% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,32.4,0,4.5,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000070886,EPHA8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.631818,0.03,-0.92913
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.1818% (minimum 99%, Missing); amygdala: 67.7419% (minimum 99%, Missing); basal ganglia: 63.6364% (minimum 99%, Missing); cerebellum: 65.6250% (minimum 99%, Missing); cerebral cortex: 53.8462% (minimum 99%, Missing); choroid plexus: 6.0870% (minimum 99%, Missing); duodenum: 77.7778% (minimum 99%, Missing); hippocampal formation: 72.4138% (minimum 99%, Missing); hypothalamus: 43.7500% (minimum 99%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 39.6226% (minimum 99%, Missing); pituitary gland: 58.3333% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing); spinal cord: 72.4138% (minimum 99%, Missing); spleen: 31.8182% (minimum 95%, Missing)",0,80,unavailable,32.4,0,4.5,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000070886,EPHA8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.631818,0.03,-0.92913
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,6,partial,5.9,7,9,"thymus: 9 nTPM (manageable, limit 5); colon: 3.7 nTPM (protected, limit 2); pituitary gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000071539,TRIP13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.6431% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.0265% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.3154% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.0946% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6395% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.0820% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.6431% (minimum 99%, Baseline (adaptation disabled)); colon: 88.6850% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.5062% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.5672% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.6395% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.7096% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.3455% (minimum 99%, Baseline (adaptation disabled)); liver: 97.3154% (minimum 99%, Baseline (adaptation disabled)); lung: 95.7096% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.5556% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.9761% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.7096% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.7712% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.0580% (minimum 97%, Baseline (adaptation disabled)); retina: 98.6395% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.9730% (minimum 99%, Baseline (adaptation disabled)); skin: 92.6518% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.9571% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.5062% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9761% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.8511% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.4625% (minimum 97%, Baseline (adaptation disabled)); thymus: 76.3158% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.1558% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,5.9,7,9,"thymus: 9 nTPM (manageable, limit 5); lymph node: 7 nTPM (protected, limit 2); bone marrow: 5.9 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); esophagus: 4.5 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000071539,TRIP13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.186842,-0.164444,-0.159054
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.0265% (minimum 99%, Missing); basal ganglia: 97.3154% (minimum 99%, Missing); bone marrow: 83.0946% (minimum 95%, Enhanced); choroid plexus: 97.6431% (minimum 99%, Missing); colon: 88.6850% (minimum 97%, Missing); duodenum: 89.5062% (minimum 95%, Enhanced); hippocampal formation: 96.6667% (minimum 99%, Missing); hypothalamus: 95.7096% (minimum 99%, Missing); midbrain: 98.9761% (minimum 99%, Missing); pituitary gland: 94.7712% (minimum 99%, Missing); retina: 98.6395% (minimum 99%, Missing); skin: 92.6518% (minimum 95%, Missing); small intestine: 88.9571% (minimum 95%, Enhanced); smooth muscle: 89.5062% (minimum 95%, Enhanced); spinal cord: 98.9761% (minimum 99%, Missing); thymus: 76.3158% (minimum 95%, Missing)",0,6,partial,5.9,7,9,"thymus: 9 nTPM (manageable, limit 5); colon: 3.7 nTPM (protected, limit 2); pituitary gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000071539,TRIP13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.186842,-0.0831498,-0.119054
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,83.9,44.2,48.6,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 3); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); spleen: 48.6 nTPM (manageable, limit 5); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 2); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (manageable, limit 5); esophagus: 41.2 nTPM (protected, limit 2); urinary bladder: 39.7 nTPM (protected, limit 2); skin: 39 nTPM (manageable, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (manageable, limit 5); stomach: 37.8 nTPM (protected, limit 2); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 3); salivary gland: 29.5 nTPM (protected, limit 6); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 2); thymus: 8.8 nTPM (manageable, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 2); smooth muscle: 7.1 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); tongue: 4.5 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000071655,MBD3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.8261% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.3412% (minimum 99%, Baseline (adaptation disabled)); amygdala: 41.3686% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 49.1682% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.8511% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 50.9579% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 38.8038% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.0070% (minimum 99%, Baseline (adaptation disabled)); colon: 54.6201% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.7888% (minimum 99%, Baseline (adaptation disabled)); esophagus: 56.3559% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 47.6703% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 41.2084% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.5750% (minimum 99%, Baseline (adaptation disabled)); kidney: 54.6763% (minimum 99%, Baseline (adaptation disabled)); liver: 47.9279% (minimum 99%, Baseline (adaptation disabled)); lung: 58.9147% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.9840% (minimum 97%, Baseline (adaptation disabled)); midbrain: 52.5173% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.5882% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.0795% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 52.2593% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.5623% (minimum 97%, Baseline (adaptation disabled)); retina: 93.1699% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.3289% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 42.6966% (minimum 99%, Baseline (adaptation disabled)); skin: 57.7007% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.2903% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.2255% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.7633% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.2593% (minimum 95%, Baseline (adaptation disabled)); stomach: 58.4615% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.8065% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.7889% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.2010% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.2659% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,83.9,44.2,48.6,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 1); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); spleen: 48.6 nTPM (manageable, limit 5); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 2); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (manageable, limit 5); esophagus: 41.2 nTPM (protected, limit 2); urinary bladder: 39.7 nTPM (protected, limit 2); skin: 39 nTPM (manageable, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (manageable, limit 5); stomach: 37.8 nTPM (protected, limit 2); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 1); salivary gland: 29.5 nTPM (protected, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 2); thymus: 8.8 nTPM (manageable, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 2); smooth muscle: 7.1 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); tongue: 4.5 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000071655,MBD3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.427407,-0.423799,-0.601962
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.8261% (minimum 95%, Missing); adrenal gland: 54.3412% (minimum 99%, Missing); amygdala: 41.3686% (minimum 99%, Missing); basal ganglia: 49.1682% (minimum 99%, Missing); bone marrow: 80.8511% (minimum 99%, Missing); cerebellum: 50.9579% (minimum 99%, Missing); cerebral cortex: 38.8038% (minimum 99%, Missing); choroid plexus: 93.0070% (minimum 99%, Missing); colon: 54.6201% (minimum 97%, Missing); duodenum: 87.7888% (minimum 99%, Missing); esophagus: 56.3559% (minimum 97%, Missing); heart muscle: 47.6703% (minimum 99%, Missing); hippocampal formation: 41.2084% (minimum 99%, Missing); hypothalamus: 53.5750% (minimum 99%, Missing); kidney: 54.6763% (minimum 99%, Missing); liver: 47.9279% (minimum 97%, Supported); lung: 58.9147% (minimum 99%, Missing); lymph node: 84.9840% (minimum 97%, Missing); midbrain: 52.5173% (minimum 99%, Missing); pancreas: 62.5882% (minimum 97%, Supported); parathyroid gland: 88.0795% (minimum 97%, Missing); pituitary gland: 52.2593% (minimum 99%, Missing); rectum: 89.5623% (minimum 97%, Missing); retina: 93.1699% (minimum 99%, Missing); salivary gland: 64.3289% (minimum 90%, Supported); skeletal muscle: 42.6966% (minimum 99%, Missing); skin: 57.7007% (minimum 95%, Missing); small intestine: 61.2903% (minimum 99%, Missing); smooth muscle: 88.2255% (minimum 99%, Missing); spinal cord: 57.7633% (minimum 99%, Missing); spleen: 52.2593% (minimum 95%, Missing); stomach: 58.4615% (minimum 97%, Missing); thymus: 85.8065% (minimum 95%, Missing); thyroid gland: 54.7889% (minimum 95%, Missing); tongue: 92.2010% (minimum 97%, Missing); urinary bladder: 57.2659% (minimum 97%, Missing)",0,3,partial,83.9,44.2,48.6,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 3); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); spleen: 48.6 nTPM (manageable, limit 5); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 2); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (manageable, limit 5); esophagus: 41.2 nTPM (protected, limit 2); urinary bladder: 39.7 nTPM (protected, limit 2); skin: 39 nTPM (manageable, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (manageable, limit 5); stomach: 37.8 nTPM (protected, limit 2); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 3); salivary gland: 29.5 nTPM (protected, limit 6); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 2); thymus: 8.8 nTPM (manageable, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 2); smooth muscle: 7.1 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); tongue: 4.5 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000071655,MBD3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.427407,-0.423799,-0.601962
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,5.7,8.5,1.2,"parathyroid gland: 8.5 nTPM (protected, limit 2); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 2)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000071909,MYO3B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 72.8723% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.1631% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.7117% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.8571% (minimum 99%, Baseline (adaptation disabled)); retina: 70.6186% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 91.9463% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 86.7089% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,5.7,8.5,1.2,"parathyroid gland: 8.5 nTPM (protected, limit 2); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000071909,MYO3B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0305369,-0.352883,-0.283814
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 72.8723% (minimum 98%, Approved); pancreas: 97.1631% (minimum 98%, Approved); parathyroid gland: 61.7117% (minimum 97%, Missing); pituitary gland: 97.8571% (minimum 99%, Missing); retina: 70.6186% (minimum 99%, Missing); urinary bladder: 86.7089% (minimum 95%, Approved)",0,1,partial,5.7,8.5,1.2,"parathyroid gland: 8.5 nTPM (protected, limit 2); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 2)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000071909,MYO3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0194631,-0.352883,-0.283814
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,45.9,35.1,32.2,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 2); thyroid gland: 32.2 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 2); tongue: 24.6 nTPM (protected, limit 2); stomach: 24.5 nTPM (protected, limit 2); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 2); adipose tissue: 20.7 nTPM (manageable, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); salivary gland: 18.5 nTPM (protected, limit 2); thymus: 18.5 nTPM (manageable, limit 5); skin: 17.9 nTPM (manageable, limit 5); colon: 17.8 nTPM (protected, limit 2); rectum: 17 nTPM (protected, limit 2); spleen: 16.4 nTPM (manageable, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 2); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000072364,AFF4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.4839% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 48.4962% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.0744% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.0739% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 37.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.4610% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.3319% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.6598% (minimum 99%, Baseline (adaptation disabled)); colon: 59.1743% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.8241% (minimum 99%, Baseline (adaptation disabled)); esophagus: 49.9033% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.8705% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.8791% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.8947% (minimum 99%, Baseline (adaptation disabled)); kidney: 52.4390% (minimum 99%, Baseline (adaptation disabled)); liver: 55.7235% (minimum 99%, Baseline (adaptation disabled)); lung: 57.4610% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.0807% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.7034% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 42.3645% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.5893% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.2804% (minimum 97%, Baseline (adaptation disabled)); retina: 35.9833% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.2393% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 51.2922% (minimum 99%, Baseline (adaptation disabled)); skin: 59.0389% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.8614% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.0864% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.1875% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.1374% (minimum 95%, Baseline (adaptation disabled)); stomach: 51.2922% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.2393% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 44.4828% (minimum 95%, Baseline (adaptation disabled)); tongue: 51.1905% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.7500% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,45.9,35.1,32.2,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 2); thyroid gland: 32.2 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 2); tongue: 24.6 nTPM (protected, limit 2); stomach: 24.5 nTPM (protected, limit 2); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 2); adipose tissue: 20.7 nTPM (manageable, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); salivary gland: 18.5 nTPM (protected, limit 2); thymus: 18.5 nTPM (manageable, limit 5); skin: 17.9 nTPM (manageable, limit 5); colon: 17.8 nTPM (protected, limit 2); rectum: 17 nTPM (protected, limit 2); spleen: 16.4 nTPM (manageable, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 2); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000072364,AFF4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.505172,-0.546355,-0.630167
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.4839% (minimum 95%, Missing); adrenal gland: 48.4962% (minimum 99%, Missing); amygdala: 71.0744% (minimum 99%, Missing); basal ganglia: 68.0739% (minimum 99%, Missing); bone marrow: 37.5000% (minimum 99%, Missing); cerebellum: 57.4610% (minimum 99%, Missing); cerebral cortex: 56.3319% (minimum 99%, Missing); choroid plexus: 75.6598% (minimum 99%, Missing); colon: 59.1743% (minimum 97%, Missing); duodenum: 64.8241% (minimum 99%, Missing); esophagus: 49.9033% (minimum 97%, Missing); heart muscle: 61.8705% (minimum 99%, Missing); hippocampal formation: 70.8791% (minimum 99%, Missing); hypothalamus: 67.8947% (minimum 99%, Missing); kidney: 52.4390% (minimum 99%, Missing); liver: 55.7235% (minimum 99%, Missing); lung: 57.4610% (minimum 99%, Missing); lymph node: 63.0807% (minimum 97%, Missing); midbrain: 71.6667% (minimum 99%, Missing); pancreas: 51.7034% (minimum 99%, Missing); parathyroid gland: 42.3645% (minimum 97%, Missing); pituitary gland: 57.5893% (minimum 99%, Missing); rectum: 60.2804% (minimum 97%, Missing); retina: 35.9833% (minimum 99%, Missing); salivary gland: 58.2393% (minimum 97%, Missing); skeletal muscle: 51.2922% (minimum 99%, Missing); skin: 59.0389% (minimum 95%, Missing); small intestine: 63.8614% (minimum 99%, Missing); smooth muscle: 53.0864% (minimum 99%, Missing); spinal cord: 67.1875% (minimum 99%, Missing); spleen: 61.1374% (minimum 95%, Missing); stomach: 51.2922% (minimum 97%, Missing); thymus: 58.2393% (minimum 95%, Missing); thyroid gland: 44.4828% (minimum 95%, Missing); tongue: 51.1905% (minimum 97%, Missing); urinary bladder: 53.7500% (minimum 97%, Missing)",0,7,partial,45.9,35.1,32.2,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 2); thyroid gland: 32.2 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 2); tongue: 24.6 nTPM (protected, limit 2); stomach: 24.5 nTPM (protected, limit 2); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 2); adipose tissue: 20.7 nTPM (manageable, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); salivary gland: 18.5 nTPM (protected, limit 2); thymus: 18.5 nTPM (manageable, limit 5); skin: 17.9 nTPM (manageable, limit 5); colon: 17.8 nTPM (protected, limit 2); rectum: 17 nTPM (protected, limit 2); spleen: 16.4 nTPM (manageable, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 2); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000072364,AFF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.505172,-0.546355,-0.630167
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,20.3,17.7,26.5,"thymus: 26.5 nTPM (manageable, limit 5); bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 2); rectum: 8.5 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); small intestine: 6.3 nTPM (vital, limit 6); stomach: 3.5 nTPM (protected, limit 2); cerebral cortex: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / sebaceous glands: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / sebaceous glands; skin 2 / cells in spinous layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000072571,HMMR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.8022% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 56.8085% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.0432% (minimum 99%, Baseline (adaptation disabled)); colon: 80.9091% (minimum 97%, Baseline (adaptation disabled)); duodenum: 78.7611% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.2549% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.0909% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8889% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8889% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.4453% (minimum 99%, Baseline (adaptation disabled)); liver: 94.0141% (minimum 99%, Baseline (adaptation disabled)); lung: 96.7391% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.1351% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.5240% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.8889% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.7391% (minimum 97%, Baseline (adaptation disabled)); rectum: 75.8523% (minimum 97%, Baseline (adaptation disabled)); retina: 97.0909% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.0432% (minimum 99%, Baseline (adaptation disabled)); skin: 86.6883% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.9091% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.5085% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.7391% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.5085% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.4106% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.1880% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.7083% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,20.3,17.7,26.5,"thymus: 26.5 nTPM (manageable, limit 5); bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 2); rectum: 8.5 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); small intestine: 6.3 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); liver: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / sebaceous glands: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / sebaceous glands; skin 2 / cells in spinous layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000072571,HMMR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.44812,-0.368649,-0.421915
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.8085% (minimum 99%, Missing); cerebral cortex: 96.0432% (minimum 99%, Missing); colon: 80.9091% (minimum 97%, Missing); duodenum: 78.7611% (minimum 99%, Missing); hippocampal formation: 98.8889% (minimum 99%, Missing); hypothalamus: 98.8889% (minimum 99%, Missing); liver: 94.0141% (minimum 95%, Enhanced); lymph node: 60.1351% (minimum 97%, Missing); midbrain: 98.5240% (minimum 99%, Missing); rectum: 75.8523% (minimum 97%, Missing); retina: 97.0909% (minimum 99%, Missing); skin: 86.6883% (minimum 95%, Missing); small intestine: 80.9091% (minimum 95%, Enhanced); smooth muscle: 90.5085% (minimum 95%, Enhanced); spinal cord: 96.7391% (minimum 99%, Missing); stomach: 88.4106% (minimum 97%, Missing); thymus: 50.1880% (minimum 95%, Missing)",0,6,partial,20.3,17.7,26.5,"thymus: 26.5 nTPM (manageable, limit 5); bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 2); rectum: 8.5 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); small intestine: 6.3 nTPM (vital, limit 6); stomach: 3.5 nTPM (protected, limit 2); cerebral cortex: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / sebaceous glands: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / sebaceous glands; skin 2 / cells in spinous layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000072571,HMMR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.44812,-0.368649,-0.421915
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,0,routine_complete,2.2,1.9,0.5,"cerebellum: 2.2 nTPM (vital, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000073146,MOV10L1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.1831% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.7290% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.9541% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.2791% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8067% (minimum 99%, Baseline (adaptation disabled)); colon: 95.6120% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.3373% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6415% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.4118% (minimum 99%, Baseline (adaptation disabled)); liver: 98.1043% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5714% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.4118% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.6415% (minimum 99%, Baseline (adaptation disabled)); retina: 96.9555% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.4118% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.5035% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.5035% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,2.2,1.9,0.5,"cerebellum: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000073146,MOV10L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0380668,-0.0138799,-0.0404587
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.1831% (minimum 99%, Missing); basal ganglia: 96.7290% (minimum 99%, Missing); cerebellum: 94.9541% (minimum 98%, Approved); cerebral cortex: 96.2791% (minimum 98%, Approved); choroid plexus: 98.8067% (minimum 99%, Missing); hippocampal formation: 97.6415% (minimum 99%, Missing); hypothalamus: 97.4118% (minimum 99%, Missing); midbrain: 97.4118% (minimum 99%, Missing); pituitary gland: 97.6415% (minimum 99%, Missing); retina: 96.9555% (minimum 99%, Missing); small intestine: 97.4118% (minimum 98%, Approved); smooth muscle: 96.5035% (minimum 98%, Approved); spinal cord: 96.5035% (minimum 99%, Missing)",0,0,routine_complete,2.2,1.9,0.5,"cerebellum: 2.2 nTPM (vital, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000073146,MOV10L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.00612009,-0.0304587
True,compatible,,True,True,False,,0,1,partial,0,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000073598,FNDC8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000073598,FNDC8,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0488453,0.0288453,0.01
True,compatible,,True,True,True,,0,1,partial,0,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000073598,FNDC8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,12.5,9.2,7.6,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 2); retina: 7.8 nTPM (vital, limit 1); thymus: 7.6 nTPM (manageable, limit 5); rectum: 5.1 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); tongue: 4.6 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000075131,TIPIN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.2636% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.2314% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.6134% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.9662% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.4198% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.9662% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.5574% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.9662% (minimum 99%, Baseline (adaptation disabled)); colon: 81.2245% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.0531% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.5668% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.8996% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.6809% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.9167% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.6134% (minimum 99%, Baseline (adaptation disabled)); liver: 80.5668% (minimum 99%, Baseline (adaptation disabled)); lung: 85.4077% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.3849% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.6134% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.5574% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.9197% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.5217% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.6000% (minimum 97%, Baseline (adaptation disabled)); retina: 71.8412% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 86.1472% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.6134% (minimum 99%, Baseline (adaptation disabled)); skin: 83.9662% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.2807% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.2314% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.2636% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.6809% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.3220% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.3636% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.2314% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.2245% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.4077% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,12.5,9.2,7.6,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 2); retina: 7.8 nTPM (vital, limit 1); thymus: 7.6 nTPM (manageable, limit 5); rectum: 5.1 nTPM (protected, limit 2); parathyroid gland: 5 nTPM (protected, limit 2); liver: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); tongue: 4.6 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000075131,TIPIN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.226364,-0.286151,-0.375802
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 82.2314% (minimum 95%, Enhanced); amygdala: 83.6134% (minimum 99%, Missing); basal ganglia: 83.9662% (minimum 99%, Missing); bone marrow: 61.4198% (minimum 99%, Missing); cerebellum: 83.9662% (minimum 95%, Enhanced); cerebral cortex: 81.5574% (minimum 95%, Enhanced); choroid plexus: 83.9662% (minimum 99%, Missing); colon: 81.2245% (minimum 97%, Missing); duodenum: 88.0531% (minimum 99%, Missing); esophagus: 80.5668% (minimum 97%, Missing); heart muscle: 86.8996% (minimum 95%, Enhanced); hippocampal formation: 84.6809% (minimum 99%, Missing); hypothalamus: 82.9167% (minimum 99%, Missing); kidney: 83.6134% (minimum 95%, Enhanced); liver: 80.5668% (minimum 95%, Enhanced); lung: 85.4077% (minimum 95%, Enhanced); lymph node: 68.3849% (minimum 97%, Missing); midbrain: 83.6134% (minimum 99%, Missing); pancreas: 81.5574% (minimum 95%, Enhanced); parathyroid gland: 79.9197% (minimum 80%, Enhanced); pituitary gland: 86.5217% (minimum 99%, Missing); rectum: 79.6000% (minimum 97%, Missing); retina: 71.8412% (minimum 99%, Missing); skeletal muscle: 83.6134% (minimum 95%, Enhanced); skin: 83.9662% (minimum 95%, Missing); small intestine: 87.2807% (minimum 99%, Missing); smooth muscle: 82.2314% (minimum 95%, Enhanced); spinal cord: 83.2636% (minimum 99%, Missing); spleen: 84.6809% (minimum 95%, Missing); stomach: 84.3220% (minimum 97%, Missing); thymus: 72.3636% (minimum 95%, Missing); tongue: 81.2245% (minimum 97%, Missing); urinary bladder: 85.4077% (minimum 97%, Missing)",0,2,partial,12.5,9.2,7.6,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 2); retina: 7.8 nTPM (vital, limit 1); thymus: 7.6 nTPM (manageable, limit 5); rectum: 5.1 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); tongue: 4.6 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000075131,TIPIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.226364,-0.286151,-0.375802
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11,9,19.1,"thymus: 19.1 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000075218,GTSE1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.1053% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5915% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.8889% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.2222% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.8904% (minimum 99%, Baseline (adaptation disabled)); colon: 75.2688% (minimum 97%, Baseline (adaptation disabled)); duodenum: 63.6364% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.8904% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5915% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5915% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.8904% (minimum 99%, Baseline (adaptation disabled)); liver: 94.5946% (minimum 99%, Baseline (adaptation disabled)); lung: 92.1053% (minimum 99%, Baseline (adaptation disabled)); lymph node: 43.7500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.5915% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.2222% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.5915% (minimum 99%, Baseline (adaptation disabled)); rectum: 73.6842% (minimum 97%, Baseline (adaptation disabled)); retina: 98.5915% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.1053% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.5915% (minimum 99%, Baseline (adaptation disabled)); skin: 74.4681% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.4198% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.2222% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.4681% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.5455% (minimum 97%, Baseline (adaptation disabled)); thymus: 26.8199% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 88.6076% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11,9,19.1,"thymus: 19.1 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000075218,GTSE1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.681801,-0.5325,-0.601111
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Missing); adrenal gland: 92.1053% (minimum 99%, Missing); basal ganglia: 98.5915% (minimum 99%, Missing); bone marrow: 38.8889% (minimum 99%, Missing); cerebellum: 97.2222% (minimum 99%, Missing); cerebral cortex: 93.3333% (minimum 99%, Missing); choroid plexus: 95.8904% (minimum 99%, Missing); colon: 75.2688% (minimum 97%, Missing); duodenum: 63.6364% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 95.8904% (minimum 99%, Missing); hippocampal formation: 98.5915% (minimum 99%, Missing); hypothalamus: 98.5915% (minimum 99%, Missing); kidney: 95.8904% (minimum 99%, Missing); liver: 94.5946% (minimum 99%, Missing); lung: 92.1053% (minimum 99%, Missing); lymph node: 43.7500% (minimum 97%, Missing); midbrain: 98.5915% (minimum 99%, Missing); pancreas: 97.2222% (minimum 99%, Missing); pituitary gland: 98.5915% (minimum 99%, Missing); rectum: 73.6842% (minimum 97%, Missing); retina: 98.5915% (minimum 99%, Missing); salivary gland: 92.1053% (minimum 97%, Missing); skeletal muscle: 98.5915% (minimum 99%, Missing); skin: 74.4681% (minimum 95%, Missing); small intestine: 71.4286% (minimum 99%, Missing); smooth muscle: 86.4198% (minimum 99%, Missing); spinal cord: 97.2222% (minimum 99%, Missing); spleen: 74.4681% (minimum 95%, Missing); stomach: 79.5455% (minimum 97%, Missing); thymus: 26.8199% (minimum 95%, Missing); urinary bladder: 88.6076% (minimum 97%, Missing)",0,80,unavailable,11,9,19.1,"thymus: 19.1 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000075218,GTSE1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.681801,-0.5325,-0.601111
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000075388,FGF4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000075388,FGF4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000075388,FGF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,6,partial,106.5,60.6,4.8,"skeletal muscle: 106.5 nTPM (vital, limit 6); tongue: 60.6 nTPM (protected, limit 2); heart muscle: 21.4 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000075702,WDR62,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 92.1131% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.2540% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.6483% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.3097% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8818% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8818% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.5247% (minimum 97%, Baseline (adaptation disabled)); retina: 90.4971% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 36.7577% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2540% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.8818% (minimum 99%, Baseline (adaptation disabled)); thymus: 92.8036% (minimum 95%, Baseline (adaptation disabled)); tongue: 50.5306% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,106.5,60.6,4.8,"skeletal muscle: 106.5 nTPM (vital, limit 1); tongue: 60.6 nTPM (protected, limit 2); heart muscle: 21.4 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000075702,WDR62,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.021964,-0.464694,-0.622423
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 92.1131% (minimum 99%, Missing); heart muscle: 74.3097% (minimum 95%, Enhanced); lymph node: 95.5247% (minimum 97%, Missing); retina: 90.4971% (minimum 99%, Missing); skeletal muscle: 36.7577% (minimum 95%, Enhanced); thymus: 92.8036% (minimum 95%, Missing); tongue: 50.5306% (minimum 97%, Missing)",0,6,partial,106.5,60.6,4.8,"skeletal muscle: 106.5 nTPM (vital, limit 6); tongue: 60.6 nTPM (protected, limit 2); heart muscle: 21.4 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000075702,WDR62,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.021964,-0.464694,-0.582423
False,excluded,rna_above_tissue_ceiling;family_exclusion,True,True,False,,0,80,unavailable,83.4,0.4,0.6,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000075886,TUBA3D,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 71.9664% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,83.4,0.4,0.6,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000075886,TUBA3D,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0472054,0.0281352,-0.270336
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 71.9664% (minimum 99%, Missing)",0,80,unavailable,83.4,0.4,0.6,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000075886,TUBA3D,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0472054,0.0281352,-0.270336
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,8,partial,39.2,13.9,17.9,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (manageable, limit 5); liver: 17.4 nTPM (vital, limit 1); thymus: 14.8 nTPM (manageable, limit 5); tongue: 13.9 nTPM (protected, limit 2); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 2); colon: 12.7 nTPM (protected, limit 2); salivary gland: 12.3 nTPM (protected, limit 2); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); stomach: 11.8 nTPM (protected, limit 2); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 2); smooth muscle: 10.5 nTPM (vital, limit 1); skin: 10.5 nTPM (manageable, limit 5); thyroid gland: 10.1 nTPM (manageable, limit 5); spleen: 9.8 nTPM (manageable, limit 5); pancreas: 9.7 nTPM (vital, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000076053,RBM7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0414% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.3725% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.4423% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.6111% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 28.8566% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.6479% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.1045% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 55.5944% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.6027% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.0173% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.3529% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.4423% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.9412% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.3830% (minimum 99%, Baseline (adaptation disabled)); liver: 47.7477% (minimum 99%, Baseline (adaptation disabled)); lung: 54.4521% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.7143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.1094% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.3466% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.4323% (minimum 99%, Baseline (adaptation disabled)); rectum: 59.5506% (minimum 97%, Baseline (adaptation disabled)); retina: 70.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.3830% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 57.6087% (minimum 99%, Baseline (adaptation disabled)); skin: 60.2273% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.1078% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.2273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.9457% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.8677% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.4007% (minimum 97%, Baseline (adaptation disabled)); thymus: 51.7915% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.1538% (minimum 95%, Baseline (adaptation disabled)); tongue: 53.3557% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.5836% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,39.2,13.9,17.9,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (manageable, limit 5); liver: 17.4 nTPM (vital, limit 1); thymus: 14.8 nTPM (manageable, limit 5); tongue: 13.9 nTPM (protected, limit 2); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 2); colon: 12.7 nTPM (protected, limit 2); salivary gland: 12.3 nTPM (protected, limit 2); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); stomach: 11.8 nTPM (protected, limit 2); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 2); smooth muscle: 10.5 nTPM (vital, limit 1); skin: 10.5 nTPM (manageable, limit 5); thyroid gland: 10.1 nTPM (manageable, limit 5); spleen: 9.8 nTPM (manageable, limit 5); pancreas: 9.7 nTPM (vital, limit 1); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000076053,RBM7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.479586,-0.436443,-0.701434
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0414% (minimum 95%, Missing); adrenal gland: 64.3725% (minimum 99%, Missing); amygdala: 76.4423% (minimum 99%, Missing); basal ganglia: 73.6111% (minimum 99%, Missing); bone marrow: 28.8566% (minimum 99%, Missing); cerebellum: 74.6479% (minimum 99%, Missing); cerebral cortex: 79.1045% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 55.5944% (minimum 97%, Missing); duodenum: 72.6027% (minimum 99%, Missing); esophagus: 55.0173% (minimum 97%, Missing); heart muscle: 62.3529% (minimum 99%, Missing); hippocampal formation: 76.4423% (minimum 99%, Missing); hypothalamus: 77.9412% (minimum 99%, Missing); kidney: 56.3830% (minimum 99%, Missing); liver: 47.7477% (minimum 99%, Missing); lung: 54.4521% (minimum 99%, Missing); lymph node: 70.6667% (minimum 97%, Missing); midbrain: 75.7143% (minimum 99%, Missing); pancreas: 62.1094% (minimum 97%, Supported); parathyroid gland: 63.3466% (minimum 97%, Missing); pituitary gland: 69.4323% (minimum 99%, Missing); rectum: 59.5506% (minimum 97%, Missing); retina: 70.6667% (minimum 99%, Missing); salivary gland: 56.3830% (minimum 97%, Missing); skeletal muscle: 57.6087% (minimum 99%, Missing); skin: 60.2273% (minimum 95%, Missing); small intestine: 59.1078% (minimum 99%, Missing); smooth muscle: 60.2273% (minimum 99%, Missing); spinal cord: 71.9457% (minimum 99%, Missing); spleen: 61.8677% (minimum 95%, Missing); stomach: 57.4007% (minimum 97%, Missing); thymus: 51.7915% (minimum 95%, Missing); thyroid gland: 61.1538% (minimum 95%, Missing); tongue: 53.3557% (minimum 97%, Missing); urinary bladder: 56.5836% (minimum 97%, Missing)",0,8,partial,39.2,13.9,17.9,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (manageable, limit 5); liver: 17.4 nTPM (vital, limit 1); thymus: 14.8 nTPM (manageable, limit 5); tongue: 13.9 nTPM (protected, limit 2); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 2); colon: 12.7 nTPM (protected, limit 2); salivary gland: 12.3 nTPM (protected, limit 2); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); stomach: 11.8 nTPM (protected, limit 2); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 2); smooth muscle: 10.5 nTPM (vital, limit 1); skin: 10.5 nTPM (manageable, limit 5); thyroid gland: 10.1 nTPM (manageable, limit 5); spleen: 9.8 nTPM (manageable, limit 5); pancreas: 9.7 nTPM (vital, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000076053,RBM7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.479586,-0.436443,-0.701434
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.2,13.7,2,"salivary gland: 13.7 nTPM (protected, limit 2); stomach: 12.6 nTPM (protected, limit 2); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 2); rectum: 8.3 nTPM (protected, limit 2); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000077274,CAPN6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 94.8835% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.6496% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.1574% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 93.8121% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.6230% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.3358% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.2805% (minimum 97%, Baseline (adaptation disabled)); tongue: 96.0240% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.2,13.7,2,"salivary gland: 13.7 nTPM (protected, limit 2); stomach: 12.6 nTPM (protected, limit 2); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 2); rectum: 8.3 nTPM (protected, limit 2); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000077274,CAPN6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,0.0404626,-0.031879,-0.0411649
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 94.8835% (minimum 99%, Missing); pancreas: 96.6496% (minimum 99%, Missing); rectum: 96.1574% (minimum 97%, Missing); salivary gland: 93.8121% (minimum 97%, Missing); skeletal muscle: 98.6230% (minimum 99%, Missing); smooth muscle: 96.3358% (minimum 99%, Missing); stomach: 94.2805% (minimum 97%, Missing); tongue: 96.0240% (minimum 97%, Missing)",0,80,unavailable,11.2,13.7,2,"salivary gland: 13.7 nTPM (protected, limit 2); stomach: 12.6 nTPM (protected, limit 2); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 2); rectum: 8.3 nTPM (protected, limit 2); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000077274,CAPN6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,0.0404626,-0.031879,-0.0411649
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,6,0.7,0.1,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000077279,DCX,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 42.4242% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 43.7500% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 18.9189% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 56.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 42.4242% (minimum 99%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.3333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 82.3529% (minimum 99%, Baseline (adaptation disabled)); retina: 40.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); spinal cord: 56.0000% (minimum 99%, Baseline (adaptation disabled)); stomach: 87.5000% (minimum 97%, Baseline (adaptation disabled)); tongue: 93.3333% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,6,0.7,0.1,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000077279,DCX,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0166667,-0.303333,-0.800811
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.5000% (minimum 95%, Enhanced); amygdala: 42.4242% (minimum 99%, Missing); basal ganglia: 43.7500% (minimum 99%, Missing); cerebellum: 93.3333% (minimum 95%, Enhanced); cerebral cortex: 18.9189% (minimum 99%, Missing); choroid plexus: 93.3333% (minimum 99%, Missing); hippocampal formation: 56.0000% (minimum 99%, Missing); hypothalamus: 42.4242% (minimum 99%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 93.3333% (minimum 95%, Enhanced); pituitary gland: 82.3529% (minimum 99%, Missing); retina: 40.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 80%, Enhanced); spinal cord: 56.0000% (minimum 99%, Missing); stomach: 87.5000% (minimum 97%, Missing); tongue: 93.3333% (minimum 97%, Missing)",0,2,partial,6,0.7,0.1,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000077279,DCX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,-0.133333,-0.800811
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,96.8,1.7,0.4,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; thymus,ENSG00000077327,SPAG6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2138% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.2091% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6287% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 49.1329% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.0276% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.5131% (minimum 99%, Baseline (adaptation disabled)); lung: 93.2203% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.7328% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 86.8152% (minimum 99%, Baseline (adaptation disabled)); retina: 94.3491% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4974% (minimum 99%, Baseline (adaptation disabled))",0,8,partial,96.8,1.7,0.4,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; thymus,ENSG00000077327,SPAG6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0457401,0.0121429,-0.498671
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2138% (minimum 99%, Missing); basal ganglia: 92.2091% (minimum 99%, Missing); choroid plexus: 49.1329% (minimum 99%, Missing); hippocampal formation: 92.0276% (minimum 99%, Missing); hypothalamus: 90.5131% (minimum 99%, Missing); lung: 93.2203% (minimum 99%, Missing); midbrain: 98.7328% (minimum 99%, Missing); pituitary gland: 86.8152% (minimum 99%, Missing); retina: 94.3491% (minimum 99%, Missing); spinal cord: 97.4974% (minimum 99%, Missing)",0,8,partial,96.8,1.7,0.4,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; thymus,ENSG00000077327,SPAG6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0457401,0.03,-0.498671
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,39,16.7,13.8,"bone marrow: 39 nTPM (vital, limit 2); lymph node: 16.7 nTPM (protected, limit 2); thymus: 13.8 nTPM (manageable, limit 5); duodenum: 8.9 nTPM (vital, limit 2); liver: 8 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 2); pancreas: 5.9 nTPM (vital, limit 2); stomach: 5.8 nTPM (protected, limit 4); retina: 5.2 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 4); lung: 4.9 nTPM (vital, limit 2); adrenal gland: 4.9 nTPM (vital, limit 2); urinary bladder: 4.7 nTPM (protected, limit 4); colon: 4.7 nTPM (protected, limit 4); salivary gland: 4.5 nTPM (protected, limit 4); smooth muscle: 4.3 nTPM (vital, limit 2); heart muscle: 3.8 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); cerebellum: 3.7 nTPM (vital, limit 2); cerebral cortex: 3.6 nTPM (vital, limit 2); tongue: 3.6 nTPM (protected, limit 2); kidney: 3 nTPM (vital, limit 2); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000077458,FAM76B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.4386% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 77.8281% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.4894% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.4894% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 30.6050% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.2967% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.6923% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.4783% (minimum 99%, Baseline (adaptation disabled)); colon: 78.5388% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.9004% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.5166% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.9048% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.0524% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.0053% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.1485% (minimum 99%, Baseline (adaptation disabled)); liver: 68.2540% (minimum 99%, Baseline (adaptation disabled)); lung: 77.8281% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.7375% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.4894% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.4589% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.6923% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.2051% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.8281% (minimum 97%, Baseline (adaptation disabled)); retina: 76.7857% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.2627% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.9048% (minimum 99%, Baseline (adaptation disabled)); skin: 75.4386% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.5043% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.8687% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.7165% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.7826% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.4839% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 76.4444% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.6923% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.5388% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,39,16.7,13.8,"bone marrow: 39 nTPM (vital, limit 1); lymph node: 16.7 nTPM (protected, limit 2); thymus: 13.8 nTPM (manageable, limit 5); duodenum: 8.9 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); liver: 8 nTPM (vital, limit 1); small intestine: 6.2 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); adipose tissue: 5.6 nTPM (manageable, limit 5); skin: 5.6 nTPM (manageable, limit 5); thyroid gland: 5.3 nTPM (manageable, limit 5); retina: 5.2 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 2); adrenal gland: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); colon: 4.7 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); heart muscle: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.6 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000077458,FAM76B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.395161,-0.462625,-0.68395
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.4386% (minimum 90%, Approved); adrenal gland: 77.8281% (minimum 98%, Approved); amygdala: 91.4894% (minimum 99%, Missing); basal ganglia: 91.4894% (minimum 99%, Missing); bone marrow: 30.6050% (minimum 98%, Approved); cerebellum: 82.2967% (minimum 98%, Approved); cerebral cortex: 82.6923% (minimum 98%, Approved); choroid plexus: 93.4783% (minimum 99%, Missing); colon: 78.5388% (minimum 95%, Approved); duodenum: 65.9004% (minimum 98%, Approved); esophagus: 81.5166% (minimum 95%, Approved); heart muscle: 81.9048% (minimum 98%, Approved); hippocampal formation: 90.0524% (minimum 99%, Missing); hypothalamus: 91.0053% (minimum 99%, Missing); kidney: 85.1485% (minimum 98%, Approved); liver: 68.2540% (minimum 98%, Approved); lung: 77.8281% (minimum 98%, Approved); lymph node: 50.7375% (minimum 97%, Missing); midbrain: 91.4894% (minimum 99%, Missing); pancreas: 74.4589% (minimum 98%, Approved); parathyroid gland: 82.6923% (minimum 95%, Approved); pituitary gland: 88.2051% (minimum 99%, Missing); rectum: 77.8281% (minimum 95%, Approved); retina: 76.7857% (minimum 99%, Missing); salivary gland: 79.2627% (minimum 95%, Approved); skeletal muscle: 81.9048% (minimum 98%, Approved); skin: 75.4386% (minimum 90%, Approved); small intestine: 73.5043% (minimum 98%, Approved); smooth muscle: 80.0000% (minimum 98%, Approved); spinal cord: 86.8687% (minimum 99%, Missing); spleen: 67.7165% (minimum 90%, Approved); stomach: 74.7826% (minimum 95%, Approved); thymus: 55.4839% (minimum 95%, Missing); thyroid gland: 76.4444% (minimum 90%, Approved); tongue: 82.6923% (minimum 97%, Missing); urinary bladder: 78.5388% (minimum 95%, Approved)",0,0,routine_complete,39,16.7,13.8,"bone marrow: 39 nTPM (vital, limit 2); lymph node: 16.7 nTPM (protected, limit 2); thymus: 13.8 nTPM (manageable, limit 5); duodenum: 8.9 nTPM (vital, limit 2); liver: 8 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 2); pancreas: 5.9 nTPM (vital, limit 2); stomach: 5.8 nTPM (protected, limit 4); retina: 5.2 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 4); lung: 4.9 nTPM (vital, limit 2); adrenal gland: 4.9 nTPM (vital, limit 2); urinary bladder: 4.7 nTPM (protected, limit 4); colon: 4.7 nTPM (protected, limit 4); salivary gland: 4.5 nTPM (protected, limit 4); smooth muscle: 4.3 nTPM (vital, limit 2); heart muscle: 3.8 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); cerebellum: 3.7 nTPM (vital, limit 2); cerebral cortex: 3.6 nTPM (vital, limit 2); tongue: 3.6 nTPM (protected, limit 2); kidney: 3 nTPM (vital, limit 2); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000077458,FAM76B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.395161,-0.462625,-0.67395
True,compatible,,True,True,False,,0,2,partial,0.2,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000077800,FKBP6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.2,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000077800,FKBP6,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0464974,0.0264974,0.00649737
True,compatible,,True,True,True,,0,2,partial,0.2,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000077800,FKBP6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0464974,0.03,0.00824561
True,compatible,,True,True,False,,0,8,partial,0.3,0.2,0.1,,,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,ENSG00000077935,SMC1B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,8,partial,0.3,0.2,0.1,,,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,ENSG00000077935,SMC1B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,0.0466997,0.0234211,0.000163934
True,compatible,,True,True,True,,0,8,partial,0.3,0.2,0.1,,,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,ENSG00000077935,SMC1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,0.0466997,0.0234211,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,15.6,11.4,8,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 6); parathyroid gland: 11.4 nTPM (protected, limit 2); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 2); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); skin: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 6); basal ganglia: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); pituitary gland: 5.5 nTPM (vital, limit 1); salivary gland: 5.3 nTPM (protected, limit 2); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000078043,PIAS2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.2857% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.6241% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.3287% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.4432% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.9449% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.5537% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.0859% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.8876% (minimum 99%, Baseline (adaptation disabled)); colon: 93.2857% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.8884% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.7750% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.8206% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.4566% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.8206% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.3287% (minimum 99%, Baseline (adaptation disabled)); liver: 91.8425% (minimum 99%, Baseline (adaptation disabled)); lung: 93.9568% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.5849% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.5849% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.0922% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.1369% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.2316% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.5687% (minimum 97%, Baseline (adaptation disabled)); retina: 86.1478% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.4929% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.7169% (minimum 99%, Baseline (adaptation disabled)); skin: 89.8212% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.0922% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.5530% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.8876% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.8425% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.6872% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.5530% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.0859% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.9507% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.2280% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,15.6,11.4,8,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 1); parathyroid gland: 11.4 nTPM (protected, limit 2); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 2); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); skin: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 2); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); midbrain: 6 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); pituitary gland: 5.5 nTPM (vital, limit 1); salivary gland: 5.3 nTPM (protected, limit 2); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000078043,PIAS2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0591405,-0.118631,-0.182831
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 92.6241% (minimum 99%, Missing); amygdala: 91.3287% (minimum 99%, Missing); basal ganglia: 90.4432% (minimum 99%, Missing); bone marrow: 89.9449% (minimum 95%, Enhanced); cerebellum: 82.5537% (minimum 95%, Enhanced); cerebral cortex: 89.0859% (minimum 99%, Missing); choroid plexus: 92.8876% (minimum 99%, Missing); esophagus: 94.7750% (minimum 97%, Missing); heart muscle: 90.8206% (minimum 99%, Missing); hippocampal formation: 91.4566% (minimum 99%, Missing); hypothalamus: 90.8206% (minimum 99%, Missing); kidney: 91.3287% (minimum 99%, Missing); liver: 91.8425% (minimum 95%, Enhanced); lung: 93.9568% (minimum 99%, Missing); lymph node: 91.5849% (minimum 97%, Missing); midbrain: 91.5849% (minimum 99%, Missing); pancreas: 94.0922% (minimum 99%, Missing); parathyroid gland: 85.1369% (minimum 97%, Missing); pituitary gland: 92.2316% (minimum 99%, Missing); retina: 86.1478% (minimum 99%, Missing); salivary gland: 92.4929% (minimum 97%, Missing); skeletal muscle: 80.7169% (minimum 99%, Missing); skin: 89.8212% (minimum 95%, Missing); small intestine: 94.0922% (minimum 95%, Enhanced); smooth muscle: 93.5530% (minimum 99%, Missing); spinal cord: 92.8876% (minimum 99%, Missing); thymus: 93.5530% (minimum 95%, Missing); thyroid gland: 89.0859% (minimum 95%, Missing); tongue: 86.9507% (minimum 97%, Missing); urinary bladder: 94.2280% (minimum 97%, Missing)",0,4,partial,15.6,11.4,8,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 6); parathyroid gland: 11.4 nTPM (protected, limit 2); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 2); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); skin: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 6); basal ganglia: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); pituitary gland: 5.5 nTPM (vital, limit 1); salivary gland: 5.3 nTPM (protected, limit 2); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000078043,PIAS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0591405,-0.118631,-0.182831
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,301,17.5,20.8,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 2); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 2); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (manageable, limit 5); salivary gland: 17.5 nTPM (protected, limit 4); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 4); skin: 14.4 nTPM (manageable, limit 10); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000078114,NEBL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 84.4595% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 23.4962% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 22.8938% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 22.6449% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 24.1779% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.2409% (minimum 99%, Baseline (adaptation disabled)); colon: 90.5797% (minimum 97%, Baseline (adaptation disabled)); esophagus: 44.4840% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 3.9872% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 28.2805% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 26.7094% (minimum 99%, Baseline (adaptation disabled)); kidney: 49.6032% (minimum 99%, Baseline (adaptation disabled)); liver: 91.2409% (minimum 99%, Baseline (adaptation disabled)); lung: 44.3262% (minimum 99%, Baseline (adaptation disabled)); midbrain: 25.3550% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.7668% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.2409% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 36.7647% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.2836% (minimum 97%, Baseline (adaptation disabled)); retina: 83.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 41.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.4198% (minimum 99%, Baseline (adaptation disabled)); skin: 46.4684% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.5797% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.8992% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 33.8753% (minimum 99%, Baseline (adaptation disabled)); stomach: 80.1282% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 37.5375% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.8992% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.2069% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,301,17.5,20.8,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 1); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 1); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (manageable, limit 5); salivary gland: 17.5 nTPM (protected, limit 2); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 2); skin: 14.4 nTPM (manageable, limit 5); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000078114,NEBL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,-0.574625,-0.553333,-0.950128
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 84.4595% (minimum 90%, Approved); adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 23.4962% (minimum 99%, Missing); basal ganglia: 22.8938% (minimum 99%, Missing); cerebellum: 22.6449% (minimum 98%, Approved); cerebral cortex: 24.1779% (minimum 98%, Approved); choroid plexus: 91.2409% (minimum 99%, Missing); colon: 90.5797% (minimum 97%, Missing); esophagus: 44.4840% (minimum 95%, Approved); heart muscle: 3.9872% (minimum 99%, Missing); hippocampal formation: 28.2805% (minimum 99%, Missing); hypothalamus: 26.7094% (minimum 99%, Missing); kidney: 49.6032% (minimum 99%, Missing); liver: 91.2409% (minimum 99%, Missing); lung: 44.3262% (minimum 99%, Missing); midbrain: 25.3550% (minimum 99%, Missing); pancreas: 64.7668% (minimum 99%, Missing); parathyroid gland: 91.2409% (minimum 97%, Missing); pituitary gland: 36.7647% (minimum 99%, Missing); rectum: 93.2836% (minimum 97%, Missing); retina: 83.3333% (minimum 99%, Missing); salivary gland: 41.6667% (minimum 95%, Approved); skeletal muscle: 95.4198% (minimum 98%, Approved); skin: 46.4684% (minimum 90%, Approved); small intestine: 90.5797% (minimum 99%, Missing); smooth muscle: 96.8992% (minimum 98%, Approved); spinal cord: 33.8753% (minimum 99%, Missing); stomach: 80.1282% (minimum 97%, Missing); thyroid gland: 37.5375% (minimum 95%, Missing); tongue: 96.8992% (minimum 97%, Missing); urinary bladder: 86.2069% (minimum 97%, Missing)",0,1,partial,301,17.5,20.8,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 2); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 2); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (manageable, limit 5); salivary gland: 17.5 nTPM (protected, limit 4); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 4); skin: 14.4 nTPM (manageable, limit 10); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000078114,NEBL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,-0.574625,-0.533333,-0.950128
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,5.4,3.5,11,"thymus: 11 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); duodenum: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000078177,N4BP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 79.0698% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.9268% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.4737% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.1795% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 45.9459% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.4737% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.9524% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 62.9630% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.8182% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.5556% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.8919% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.9524% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.8333% (minimum 99%, Baseline (adaptation disabled)); liver: 38.6364% (minimum 99%, Baseline (adaptation disabled)); lung: 68.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.2754% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.8919% (minimum 99%, Baseline (adaptation disabled)); pancreas: 45.9459% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 72.3404% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.9130% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.8182% (minimum 97%, Baseline (adaptation disabled)); retina: 62.9630% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.5152% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.9268% (minimum 99%, Baseline (adaptation disabled)); skin: 65.3846% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.9630% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.9268% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.4737% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.3846% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.3846% (minimum 97%, Baseline (adaptation disabled)); thymus: 23.6111% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 51.5152% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.0698% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.1509% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,5.4,3.5,11,"thymus: 11 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); duodenum: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000078177,N4BP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.713889,-0.477246,-0.603636
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 79.0698% (minimum 95%, Missing); adrenal gland: 82.9268% (minimum 99%, Missing); amygdala: 89.4737% (minimum 99%, Missing); basal ganglia: 87.1795% (minimum 99%, Missing); bone marrow: 45.9459% (minimum 99%, Missing); cerebellum: 89.4737% (minimum 99%, Missing); cerebral cortex: 80.9524% (minimum 99%, Missing); choroid plexus: 85.0000% (minimum 99%, Missing); colon: 62.9630% (minimum 97%, Missing); duodenum: 61.8182% (minimum 99%, Missing); esophagus: 68.0000% (minimum 97%, Missing); heart muscle: 75.5556% (minimum 99%, Missing); hippocampal formation: 91.8919% (minimum 99%, Missing); hypothalamus: 80.9524% (minimum 99%, Missing); kidney: 70.8333% (minimum 99%, Missing); liver: 38.6364% (minimum 99%, Missing); lung: 68.0000% (minimum 99%, Missing); lymph node: 49.2754% (minimum 97%, Missing); midbrain: 91.8919% (minimum 99%, Missing); pancreas: 45.9459% (minimum 99%, Missing); parathyroid gland: 72.3404% (minimum 97%, Missing); pituitary gland: 73.9130% (minimum 99%, Missing); rectum: 61.8182% (minimum 97%, Missing); retina: 62.9630% (minimum 99%, Missing); salivary gland: 51.5152% (minimum 97%, Missing); skeletal muscle: 82.9268% (minimum 99%, Missing); skin: 65.3846% (minimum 95%, Missing); small intestine: 62.9630% (minimum 99%, Missing); smooth muscle: 82.9268% (minimum 99%, Missing); spinal cord: 89.4737% (minimum 99%, Missing); spleen: 65.3846% (minimum 95%, Missing); stomach: 65.3846% (minimum 97%, Missing); thymus: 23.6111% (minimum 95%, Missing); thyroid gland: 51.5152% (minimum 95%, Missing); tongue: 79.0698% (minimum 97%, Missing); urinary bladder: 64.1509% (minimum 97%, Missing)",0,3,partial,5.4,3.5,11,"thymus: 11 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); duodenum: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000078177,N4BP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.713889,-0.477246,-0.603636
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.7,4.3,4.7,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 2); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000078487,ZCWPW1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3937% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.2922% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.1875% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.0180% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.6508% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.3811% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.8090% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.1700% (minimum 99%, Baseline (adaptation disabled)); colon: 92.6009% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.4057% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.9425% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.7778% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.9822% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.2280% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.6009% (minimum 99%, Baseline (adaptation disabled)); liver: 87.8723% (minimum 99%, Baseline (adaptation disabled)); lung: 94.7248% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.5743% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.9782% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.9425% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.7692% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.3811% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.8237% (minimum 97%, Baseline (adaptation disabled)); retina: 93.0180% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.3811% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.7778% (minimum 99%, Baseline (adaptation disabled)); skin: 90.3720% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.2922% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.0774% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.2479% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.7692% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.5080% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.0774% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.7826% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.5702% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 91.7778% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.7,4.3,4.7,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 2); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000078487,ZCWPW1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0521739,-0.0642982,-0.111277
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3937% (minimum 95%, Missing); adrenal gland: 94.2922% (minimum 99%, Missing); amygdala: 92.1875% (minimum 99%, Missing); basal ganglia: 93.0180% (minimum 99%, Missing); bone marrow: 93.6508% (minimum 99%, Missing); cerebellum: 95.3811% (minimum 99%, Missing); cerebral cortex: 92.8090% (minimum 99%, Missing); choroid plexus: 91.1700% (minimum 99%, Missing); colon: 92.6009% (minimum 97%, Missing); duodenum: 97.4057% (minimum 99%, Missing); esophagus: 94.9425% (minimum 97%, Missing); heart muscle: 91.7778% (minimum 99%, Missing); hippocampal formation: 91.9822% (minimum 99%, Missing); hypothalamus: 93.2280% (minimum 99%, Missing); kidney: 92.6009% (minimum 99%, Missing); liver: 87.8723% (minimum 99%, Missing); lung: 94.7248% (minimum 99%, Missing); lymph node: 91.5743% (minimum 97%, Missing); midbrain: 89.9782% (minimum 99%, Missing); pancreas: 94.9425% (minimum 99%, Missing); parathyroid gland: 90.7692% (minimum 97%, Missing); pituitary gland: 95.3811% (minimum 99%, Missing); rectum: 95.8237% (minimum 97%, Missing); retina: 93.0180% (minimum 99%, Missing); salivary gland: 95.3811% (minimum 97%, Missing); skeletal muscle: 91.7778% (minimum 99%, Missing); skin: 90.3720% (minimum 95%, Missing); small intestine: 94.2922% (minimum 99%, Missing); smooth muscle: 94.0774% (minimum 99%, Missing); spinal cord: 88.2479% (minimum 99%, Missing); spleen: 90.7692% (minimum 95%, Missing); stomach: 94.5080% (minimum 97%, Missing); thymus: 94.0774% (minimum 95%, Missing); thyroid gland: 89.7826% (minimum 95%, Missing); tongue: 90.5702% (minimum 97%, Missing); urinary bladder: 91.7778% (minimum 97%, Missing)",0,80,unavailable,5.7,4.3,4.7,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 2); choroid plexus: 4 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 2); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000078487,ZCWPW1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0521739,-0.0642982,-0.111277
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,2.2,0.8,0.7,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000078795,PKD2L2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 89.7727% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.5309% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.3415% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.9462% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.0476% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.5309% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.3415% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.1807% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.7778% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.5309% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.5309% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.7500% (minimum 99%, Baseline (adaptation disabled)); liver: 98.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 98.7500% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.8046% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.5309% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.7727% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.3415% (minimum 99%, Baseline (adaptation disabled)); retina: 87.7778% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.1807% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.2178% (minimum 99%, Baseline (adaptation disabled)); skin: 94.0476% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.5309% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7500% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.5309% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.8605% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.1807% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.9412% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.8605% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,2.2,0.8,0.7,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000078795,PKD2L2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0313953,-0.061954,-0.207822
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 89.7727% (minimum 99%, Missing); amygdala: 97.5309% (minimum 99%, Missing); basal ganglia: 96.3415% (minimum 99%, Missing); bone marrow: 84.9462% (minimum 99%, Missing); cerebellum: 98.7500% (minimum 99%, Missing); cerebral cortex: 94.0476% (minimum 99%, Missing); choroid plexus: 97.5309% (minimum 99%, Missing); duodenum: 96.3415% (minimum 99%, Missing); esophagus: 95.1807% (minimum 97%, Missing); heart muscle: 87.7778% (minimum 99%, Missing); hippocampal formation: 97.5309% (minimum 99%, Missing); hypothalamus: 97.5309% (minimum 99%, Missing); kidney: 98.7500% (minimum 99%, Missing); liver: 98.7500% (minimum 99%, Missing); lung: 98.7500% (minimum 99%, Missing); lymph node: 90.8046% (minimum 97%, Missing); midbrain: 97.5309% (minimum 99%, Missing); pancreas: 89.7727% (minimum 99%, Missing); pituitary gland: 96.3415% (minimum 99%, Missing); retina: 87.7778% (minimum 99%, Missing); salivary gland: 95.1807% (minimum 97%, Missing); skeletal muscle: 78.2178% (minimum 99%, Missing); skin: 94.0476% (minimum 95%, Missing); small intestine: 97.5309% (minimum 99%, Missing); spinal cord: 97.5309% (minimum 99%, Missing); spleen: 91.8605% (minimum 95%, Missing); stomach: 95.1807% (minimum 97%, Missing); thyroid gland: 92.9412% (minimum 95%, Missing); tongue: 91.8605% (minimum 97%, Missing)",0,3,partial,2.2,0.8,0.7,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000078795,PKD2L2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0313953,-0.061954,-0.207822
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,288.9,3.3,5.9,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000079101,CLUL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.3750% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.0672% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.8846% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.3226% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 22.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 90.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.1860% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.0968% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.5904% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.6814% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.8276% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.8321% (minimum 99%, Baseline (adaptation disabled)); liver: 94.1860% (minimum 99%, Baseline (adaptation disabled)); lung: 86.1702% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.0455% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.3119% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.0968% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.0526% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.2308% (minimum 99%, Baseline (adaptation disabled)); retina: 2.7273% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.4118% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.5904% (minimum 99%, Baseline (adaptation disabled)); skin: 92.0455% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.1702% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.8276% (minimum 99%, Baseline (adaptation disabled)); stomach: 73.6364% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.6531% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.8571% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 91.0112% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,288.9,3.3,5.9,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); kidney: 5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); hippocampal formation: 3.2 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000079101,CLUL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.371429,-0.259474,-0.962727
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.0000% (minimum 95%, Enhanced); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 84.3750% (minimum 99%, Missing); bone marrow: 68.0672% (minimum 95%, Enhanced); cerebellum: 77.8846% (minimum 95%, Enhanced); cerebral cortex: 65.3226% (minimum 95%, Enhanced); choroid plexus: 22.5000% (minimum 99%, Missing); duodenum: 94.1860% (minimum 95%, Enhanced); hippocampal formation: 71.6814% (minimum 99%, Missing); hypothalamus: 69.8276% (minimum 99%, Missing); kidney: 61.8321% (minimum 95%, Enhanced); liver: 94.1860% (minimum 95%, Enhanced); lung: 86.1702% (minimum 95%, Enhanced); midbrain: 74.3119% (minimum 99%, Missing); pancreas: 87.0968% (minimum 95%, Enhanced); parathyroid gland: 71.0526% (minimum 80%, Enhanced); pituitary gland: 69.2308% (minimum 99%, Missing); retina: 2.7273% (minimum 99%, Missing); salivary gland: 79.4118% (minimum 80%, Enhanced); small intestine: 86.1702% (minimum 95%, Enhanced); spinal cord: 69.8276% (minimum 99%, Missing); stomach: 73.6364% (minimum 80%, Enhanced); thymus: 82.6531% (minimum 95%, Missing); thyroid gland: 57.8571% (minimum 60%, Enhanced)",0,2,partial,288.9,3.3,5.9,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000079101,CLUL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.123469,-0.0894737,-0.962727
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,63.6,2,0.2,"cerebellum: 63.6 nTPM (vital, limit 6); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000079841,RIMS1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 78.4314% (minimum 99%, Baseline (adaptation disabled)); amygdala: 15.3257% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 33.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 5.9172% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 13.6519% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); colon: 93.0233% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.1064% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.5610% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 17.4672% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 37.0370% (minimum 99%, Baseline (adaptation disabled)); lung: 95.2381% (minimum 99%, Baseline (adaptation disabled)); midbrain: 46.5116% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.9091% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 72.7273% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.4921% (minimum 99%, Baseline (adaptation disabled)); retina: 36.0360% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); small intestine: 90.9091% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.1064% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 58.8235% (minimum 99%, Baseline (adaptation disabled)); stomach: 75.4717% (minimum 97%, Baseline (adaptation disabled)); tongue: 81.6327% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,63.6,2,0.2,"cerebellum: 63.6 nTPM (vital, limit 1); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000079841,RIMS1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.00238095,-0.303333,-0.930828
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 78.4314% (minimum 95%, Enhanced); amygdala: 15.3257% (minimum 99%, Missing); basal ganglia: 33.3333% (minimum 99%, Missing); cerebellum: 5.9172% (minimum 95%, Enhanced); cerebral cortex: 13.6519% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); duodenum: 85.1064% (minimum 95%, Enhanced); esophagus: 66.6667% (minimum 80%, Enhanced); hippocampal formation: 17.4672% (minimum 99%, Missing); hypothalamus: 37.0370% (minimum 99%, Missing); midbrain: 46.5116% (minimum 99%, Missing); pancreas: 90.9091% (minimum 95%, Enhanced); parathyroid gland: 72.7273% (minimum 80%, Enhanced); pituitary gland: 63.4921% (minimum 99%, Missing); retina: 36.0360% (minimum 99%, Missing); small intestine: 90.9091% (minimum 95%, Enhanced); smooth muscle: 85.1064% (minimum 95%, Enhanced); spinal cord: 58.8235% (minimum 99%, Missing); stomach: 75.4717% (minimum 80%, Enhanced); tongue: 81.6327% (minimum 97%, Missing)",0,1,partial,63.6,2,0.2,"cerebellum: 63.6 nTPM (vital, limit 6); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000079841,RIMS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,-0.153673,-0.890828
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,2,partial,1.2,1.8,1.4,,lung / macrophages: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000080007,DDX43,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.9381% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.4456% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.9583% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.4467% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.4467% (minimum 99%, Baseline (adaptation disabled)); colon: 95.4774% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.0594% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.4774% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.4467% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.4456% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.4456% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.9596% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9583% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.4467% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.9388% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.0594% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.4456% (minimum 99%, Baseline (adaptation disabled)); retina: 97.9381% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.3462% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.9583% (minimum 99%, Baseline (adaptation disabled)); skin: 94.0594% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.9596% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.9596% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.9596% (minimum 99%, Baseline (adaptation disabled)); stomach: 91.7874% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.1373% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.0000% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,1.2,1.8,1.4,"duodenum: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000080007,DDX43,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0186275,-0.0565385,-0.0494059
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.4456% (minimum 99%, Missing); basal ganglia: 98.9583% (minimum 99%, Missing); choroid plexus: 96.4467% (minimum 99%, Missing); duodenum: 94.0594% (minimum 95%, Enhanced); hippocampal formation: 98.4456% (minimum 99%, Missing); hypothalamus: 98.4456% (minimum 99%, Missing); lung: 95.0000% (minimum 99%, Missing); midbrain: 96.9388% (minimum 99%, Missing); pancreas: 94.0594% (minimum 95%, Enhanced); pituitary gland: 98.4456% (minimum 99%, Missing); retina: 97.9381% (minimum 99%, Missing); spinal cord: 95.9596% (minimum 99%, Missing)",0,2,partial,1.2,1.8,1.4,,lung / macrophages: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000080007,DDX43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0395833,0.014456,-0.04
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.1,3.1,1.9,"colon: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,ENSG00000080224,EPHA6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.9091% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.4742% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.7654% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.1064% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.2079% (minimum 99%, Baseline (adaptation disabled)); colon: 72.0721% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.7654% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.9091% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.3855% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.9540% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.2381% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.2381% (minimum 99%, Baseline (adaptation disabled)); lung: 98.7654% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.5610% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.1176% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.7654% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.0233% (minimum 97%, Baseline (adaptation disabled)); retina: 87.9121% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.3855% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.1064% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7654% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.0233% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 80.8081% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 86.0215% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.1,3.1,1.9,"colon: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,ENSG00000080224,EPHA6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.141919,-0.249279,-0.197921
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.9091% (minimum 99%, Missing); basal ganglia: 82.4742% (minimum 99%, Missing); bone marrow: 98.7654% (minimum 99%, Missing); cerebellum: 85.1064% (minimum 99%, Missing); cerebral cortex: 79.2079% (minimum 99%, Missing); colon: 72.0721% (minimum 97%, Missing); duodenum: 98.7654% (minimum 99%, Missing); esophagus: 90.9091% (minimum 97%, Missing); heart muscle: 96.3855% (minimum 99%, Missing); hippocampal formation: 91.9540% (minimum 99%, Missing); hypothalamus: 95.2381% (minimum 99%, Missing); kidney: 95.2381% (minimum 99%, Missing); lung: 98.7654% (minimum 99%, Missing); midbrain: 97.5610% (minimum 99%, Missing); pancreas: 94.1176% (minimum 99%, Missing); pituitary gland: 98.7654% (minimum 99%, Missing); rectum: 93.0233% (minimum 97%, Missing); retina: 87.9121% (minimum 99%, Missing); small intestine: 96.3855% (minimum 99%, Missing); smooth muscle: 85.1064% (minimum 99%, Missing); spinal cord: 98.7654% (minimum 99%, Missing); stomach: 93.0233% (minimum 97%, Missing); thyroid gland: 80.8081% (minimum 95%, Missing); urinary bladder: 86.0215% (minimum 97%, Missing)",0,80,unavailable,2.1,3.1,1.9,"colon: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,ENSG00000080224,EPHA6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.141919,-0.249279,-0.197921
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,3.9,0,0.2,"choroid plexus: 3.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),56,not_established,not_triggered,,,ENSG00000080572,DNAAF6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.8678% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.8000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.8387% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.8000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.8000% (minimum 99%, Baseline (adaptation disabled)); lung: 90.6250% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.3051% (minimum 99%, Baseline (adaptation disabled))",0,7,partial,3.9,0,0.2,"choroid plexus: 3.9 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),56,not_established,not_triggered,,,ENSG00000080572,DNAAF6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0330508,0.03,-0.241613
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.8678% (minimum 99%, Missing); basal ganglia: 92.8000% (minimum 99%, Missing); choroid plexus: 74.8387% (minimum 99%, Missing); hippocampal formation: 92.8000% (minimum 99%, Missing); hypothalamus: 92.8000% (minimum 99%, Missing); lung: 90.6250% (minimum 95%, Enhanced); spinal cord: 98.3051% (minimum 99%, Missing)",0,7,partial,3.9,0,0.2,"choroid plexus: 3.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),56,not_established,not_triggered,,,ENSG00000080572,DNAAF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.03,-0.241613
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,81,36,33,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 2); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 2); skin: 33 nTPM (manageable, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (manageable, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 2); esophagus: 25.6 nTPM (protected, limit 2); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 2); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 2); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 10); salivary gland: 21.3 nTPM (protected, limit 2); smooth muscle: 20.4 nTPM (vital, limit 1); thymus: 19.2 nTPM (manageable, limit 5); choroid plexus: 19 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 2); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 2); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000080815,PSEN1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.7765% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.5644% (minimum 99%, Baseline (adaptation disabled)); amygdala: 55.9233% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 51.8578% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 70.3947% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.8841% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.7688% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.8180% (minimum 99%, Baseline (adaptation disabled)); colon: 47.1366% (minimum 97%, Baseline (adaptation disabled)); duodenum: 45.2113% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.6326% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.1348% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 47.3451% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.3636% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.1546% (minimum 99%, Baseline (adaptation disabled)); liver: 59.3346% (minimum 99%, Baseline (adaptation disabled)); lung: 56.9149% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.0323% (minimum 97%, Baseline (adaptation disabled)); midbrain: 44.8324% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.8750% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.5363% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 74.6512% (minimum 99%, Baseline (adaptation disabled)); rectum: 49.1577% (minimum 97%, Baseline (adaptation disabled)); retina: 74.6512% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.1124% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 64.9798% (minimum 99%, Baseline (adaptation disabled)); skin: 49.3088% (minimum 95%, Baseline (adaptation disabled)); small intestine: 44.7075% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.1429% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 28.3820% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.8171% (minimum 95%, Baseline (adaptation disabled)); stomach: 58.1522% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.5731% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.4992% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.3223% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.2172% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,81,36,33,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 2); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 2); skin: 33 nTPM (manageable, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (manageable, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 2); esophagus: 25.6 nTPM (protected, limit 2); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 2); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 2); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); salivary gland: 21.3 nTPM (protected, limit 2); smooth muscle: 20.4 nTPM (vital, limit 1); thymus: 19.2 nTPM (manageable, limit 5); choroid plexus: 19 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 2); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 2); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000080815,PSEN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.456912,-0.498634,-0.70618
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.7765% (minimum 90%, Approved); adrenal gland: 63.5644% (minimum 99%, Missing); amygdala: 55.9233% (minimum 99%, Missing); basal ganglia: 51.8578% (minimum 99%, Missing); bone marrow: 70.3947% (minimum 99%, Missing); cerebellum: 68.8841% (minimum 99%, Missing); cerebral cortex: 53.7688% (minimum 99%, Missing); choroid plexus: 62.8180% (minimum 99%, Missing); colon: 47.1366% (minimum 97%, Missing); duodenum: 45.2113% (minimum 99%, Missing); esophagus: 55.6326% (minimum 97%, Missing); heart muscle: 72.1348% (minimum 99%, Missing); hippocampal formation: 47.3451% (minimum 99%, Missing); hypothalamus: 58.3636% (minimum 99%, Missing); kidney: 55.1546% (minimum 99%, Missing); liver: 59.3346% (minimum 99%, Missing); lung: 56.9149% (minimum 99%, Missing); lymph node: 69.0323% (minimum 97%, Missing); midbrain: 44.8324% (minimum 99%, Missing); pancreas: 66.8750% (minimum 99%, Missing); parathyroid gland: 55.5363% (minimum 97%, Missing); pituitary gland: 74.6512% (minimum 99%, Missing); rectum: 49.1577% (minimum 97%, Missing); retina: 74.6512% (minimum 99%, Missing); salivary gland: 60.1124% (minimum 97%, Missing); skeletal muscle: 64.9798% (minimum 99%, Missing); skin: 49.3088% (minimum 95%, Missing); small intestine: 44.7075% (minimum 99%, Missing); smooth muscle: 61.1429% (minimum 99%, Missing); spinal cord: 28.3820% (minimum 99%, Missing); spleen: 63.8171% (minimum 95%, Missing); stomach: 58.1522% (minimum 97%, Missing); thymus: 62.5731% (minimum 95%, Missing); thyroid gland: 54.4992% (minimum 95%, Missing); tongue: 66.3223% (minimum 97%, Missing); urinary bladder: 56.2172% (minimum 97%, Missing)",0,5,partial,81,36,33,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 2); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 2); skin: 33 nTPM (manageable, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (manageable, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 2); esophagus: 25.6 nTPM (protected, limit 2); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 2); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 2); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 10); salivary gland: 21.3 nTPM (protected, limit 2); smooth muscle: 20.4 nTPM (vital, limit 1); thymus: 19.2 nTPM (manageable, limit 5); choroid plexus: 19 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 2); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 2); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000080815,PSEN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.456912,-0.498634,-0.70618
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,9,partial,14.3,7.6,8.5,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 7.6 nTPM (protected, limit 2); lymph node: 7.1 nTPM (protected, limit 2); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000080839,RBL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.2642% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.7500% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 18.7500% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.8966% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.2128% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.5714% (minimum 99%, Baseline (adaptation disabled)); colon: 55.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.9286% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.0984% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.7442% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.3469% (minimum 99%, Baseline (adaptation disabled)); liver: 71.7391% (minimum 99%, Baseline (adaptation disabled)); lung: 61.1111% (minimum 99%, Baseline (adaptation disabled)); lymph node: 31.7308% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.9286% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 56.8966% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 49.2537% (minimum 97%, Baseline (adaptation disabled)); retina: 45.8333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.2128% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 33.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 51.5625% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.8947% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.7500% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.9322% (minimum 97%, Baseline (adaptation disabled)); thymus: 27.9661% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.9322% (minimum 95%, Baseline (adaptation disabled)); tongue: 30.2752% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.4615% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,14.3,7.6,8.5,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 7.6 nTPM (protected, limit 2); lymph node: 7.1 nTPM (protected, limit 2); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000080839,RBL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.670339,-0.667248,-0.8025
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.7500% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 18.7500% (minimum 99%, Missing); cerebellum: 56.8966% (minimum 99%, Missing); cerebral cortex: 70.2128% (minimum 99%, Missing); choroid plexus: 78.5714% (minimum 99%, Missing); colon: 55.0000% (minimum 97%, Missing); duodenum: 58.9286% (minimum 99%, Missing); esophagus: 54.0984% (minimum 97%, Missing); heart muscle: 66.0000% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 76.7442% (minimum 99%, Missing); kidney: 67.3469% (minimum 99%, Missing); liver: 71.7391% (minimum 99%, Missing); lung: 61.1111% (minimum 99%, Missing); lymph node: 31.7308% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 58.9286% (minimum 99%, Missing); parathyroid gland: 56.8966% (minimum 97%, Missing); pituitary gland: 75.0000% (minimum 99%, Missing); rectum: 49.2537% (minimum 97%, Missing); retina: 45.8333% (minimum 99%, Missing); salivary gland: 70.2128% (minimum 97%, Missing); skeletal muscle: 33.0000% (minimum 99%, Missing); skin: 51.5625% (minimum 95%, Missing); small intestine: 57.8947% (minimum 99%, Missing); smooth muscle: 55.0000% (minimum 99%, Missing); spinal cord: 68.7500% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 55.9322% (minimum 97%, Missing); thymus: 27.9661% (minimum 95%, Missing); thyroid gland: 55.9322% (minimum 95%, Missing); tongue: 30.2752% (minimum 97%, Missing); urinary bladder: 63.4615% (minimum 97%, Missing)",0,9,partial,14.3,7.6,8.5,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 7.6 nTPM (protected, limit 2); lymph node: 7.1 nTPM (protected, limit 2); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000080839,RBL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.670339,-0.667248,-0.8025
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,3,1.4,0.2,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000081842,PCDHA6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 42.8571% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 31.5789% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 16.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 20.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.7143% (minimum 99%, Baseline (adaptation disabled)); colon: 85.7143% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 37.5000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 30.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.7143% (minimum 97%, Baseline (adaptation disabled)); midbrain: 42.8571% (minimum 99%, Baseline (adaptation disabled)); pancreas: 37.5000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 30.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 28.5714% (minimum 99%, Baseline (adaptation disabled)); retina: 35.2941% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.7143% (minimum 97%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 31.5789% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.7143% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.0000% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,3,1.4,0.2,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000081842,PCDHA6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.2,-0.67,-0.823333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 95%, Enhanced); amygdala: 42.8571% (minimum 99%, Missing); basal ganglia: 31.5789% (minimum 99%, Missing); cerebellum: 16.6667% (minimum 99%, Missing); cerebral cortex: 20.0000% (minimum 99%, Missing); choroid plexus: 85.7143% (minimum 99%, Missing); duodenum: 75.0000% (minimum 95%, Enhanced); heart muscle: 85.7143% (minimum 95%, Enhanced); hippocampal formation: 37.5000% (minimum 99%, Missing); hypothalamus: 30.0000% (minimum 99%, Missing); kidney: 60.0000% (minimum 95%, Enhanced); lung: 75.0000% (minimum 95%, Enhanced); midbrain: 42.8571% (minimum 99%, Missing); pancreas: 37.5000% (minimum 95%, Enhanced); parathyroid gland: 30.0000% (minimum 80%, Enhanced); pituitary gland: 28.5714% (minimum 99%, Missing); retina: 35.2941% (minimum 99%, Missing); small intestine: 75.0000% (minimum 95%, Enhanced); smooth muscle: 75.0000% (minimum 95%, Enhanced); spinal cord: 31.5789% (minimum 99%, Missing)",0,3,partial,3,1.4,0.2,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000081842,PCDHA6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,-0.5,-0.823333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.4,1.6,1.7,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000081985,IL12RB2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.0123% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.9697% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.9697% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.7536% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.1905% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.4615% (minimum 99%, Baseline (adaptation disabled)); colon: 95.5224% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.9697% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.1408% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.4615% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.4865% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.4615% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.5224% (minimum 99%, Baseline (adaptation disabled)); liver: 90.1408% (minimum 99%, Baseline (adaptation disabled)); lung: 94.1176% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled)); pancreas: 71.9101% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.7536% (minimum 97%, Baseline (adaptation disabled)); rectum: 95.5224% (minimum 97%, Baseline (adaptation disabled)); retina: 98.4615% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 86.4865% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.3061% (minimum 99%, Baseline (adaptation disabled)); skin: 86.4865% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.5224% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.9697% (minimum 97%, Baseline (adaptation disabled)); thymus: 87.6712% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.8889% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 91.4286% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.4,1.6,1.7,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000081985,IL12RB2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.159877,-0.17,-0.336939
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.0123% (minimum 95%, Missing); adrenal gland: 96.9697% (minimum 99%, Missing); amygdala: 96.9697% (minimum 99%, Missing); bone marrow: 92.7536% (minimum 99%, Missing); cerebral cortex: 76.1905% (minimum 99%, Missing); choroid plexus: 98.4615% (minimum 99%, Missing); colon: 95.5224% (minimum 97%, Missing); duodenum: 96.9697% (minimum 99%, Missing); esophagus: 90.1408% (minimum 97%, Missing); heart muscle: 98.4615% (minimum 99%, Missing); hippocampal formation: 86.4865% (minimum 99%, Missing); hypothalamus: 98.4615% (minimum 99%, Missing); kidney: 95.5224% (minimum 99%, Missing); liver: 90.1408% (minimum 99%, Missing); lung: 94.1176% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); pancreas: 71.9101% (minimum 99%, Missing); parathyroid gland: 92.7536% (minimum 97%, Missing); rectum: 95.5224% (minimum 97%, Missing); retina: 98.4615% (minimum 99%, Missing); salivary gland: 86.4865% (minimum 97%, Missing); skeletal muscle: 65.3061% (minimum 99%, Missing); skin: 86.4865% (minimum 95%, Missing); small intestine: 95.5224% (minimum 99%, Missing); smooth muscle: 94.1176% (minimum 99%, Missing); spleen: 85.3333% (minimum 95%, Missing); stomach: 96.9697% (minimum 97%, Missing); thymus: 87.6712% (minimum 95%, Missing); tongue: 88.8889% (minimum 97%, Missing); urinary bladder: 91.4286% (minimum 97%, Missing)",0,80,unavailable,3.4,1.6,1.7,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000081985,IL12RB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.159877,-0.17,-0.336939
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,676.9,0.4,0.8,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 6); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000083067,TRPM3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.7407% (minimum 99%, Baseline (adaptation disabled)); amygdala: 49.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.9767% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.0784% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 27.3743% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.9767% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 0.7187% (minimum 99%, Baseline (adaptation disabled)); duodenum: 94.2308% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 85.9649% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.6818% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 48.5149% (minimum 99%, Baseline (adaptation disabled)); kidney: 24.6231% (minimum 99%, Baseline (adaptation disabled)); liver: 96.0784% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 37.9845% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.2308% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 63.6364% (minimum 99%, Baseline (adaptation disabled)); retina: 20.6751% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.2500% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.2308% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.4528% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 85.9649% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,676.9,0.4,0.8,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000083067,TRPM3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0903509,-0.0454717,-0.982813
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.7407% (minimum 95%, Enhanced); amygdala: 49.0000% (minimum 99%, Missing); basal ganglia: 56.9767% (minimum 99%, Missing); cerebellum: 27.3743% (minimum 95%, Enhanced); cerebral cortex: 56.9767% (minimum 95%, Enhanced); choroid plexus: 0.7187% (minimum 99%, Missing); duodenum: 94.2308% (minimum 95%, Enhanced); heart muscle: 85.9649% (minimum 95%, Enhanced); hippocampal formation: 55.6818% (minimum 99%, Missing); hypothalamus: 48.5149% (minimum 99%, Missing); kidney: 24.6231% (minimum 99%, Missing); midbrain: 37.9845% (minimum 99%, Missing); pancreas: 94.2308% (minimum 95%, Enhanced); pituitary gland: 63.6364% (minimum 99%, Missing); retina: 20.6751% (minimum 99%, Missing); spinal cord: 61.2500% (minimum 99%, Missing)",0,4,partial,676.9,0.4,0.8,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 6); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000083067,TRPM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.03,0.01,-0.982813
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,35.9,14.1,10.2,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 2); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 2); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 2); adipose tissue: 10.2 nTPM (manageable, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 2); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pancreas: 7.3 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); esophagus: 6.1 nTPM (protected, limit 2); salivary gland: 5.7 nTPM (protected, limit 2); pituitary gland: 5.2 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000083290,ULK2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.2791% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.0380% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.3137% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 67.3511% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.6201% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.4401% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.9505% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.5426% (minimum 99%, Baseline (adaptation disabled)); colon: 75.7506% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.8768% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.3188% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.3922% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.8221% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.9957% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.6735% (minimum 99%, Baseline (adaptation disabled)); liver: 90.8587% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.4667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.0038% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.7955% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.9298% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.3158% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 78.0952% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.1948% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.0526% (minimum 99%, Baseline (adaptation disabled)); skin: 81.7955% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.9357% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.0952% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 47.7438% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.4121% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.6175% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.1026% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.9360% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 79.0361% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,35.9,14.1,10.2,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 2); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 2); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 2); adipose tissue: 10.2 nTPM (manageable, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 2); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pancreas: 7.3 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); esophagus: 6.1 nTPM (protected, limit 2); salivary gland: 5.7 nTPM (protected, limit 2); pituitary gland: 5.2 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000083290,ULK2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.187209,-0.27064,-0.512562
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.2791% (minimum 95%, Missing); adrenal gland: 83.0380% (minimum 99%, Missing); amygdala: 64.3137% (minimum 99%, Missing); basal ganglia: 67.3511% (minimum 99%, Missing); bone marrow: 91.6201% (minimum 99%, Missing); cerebellum: 64.4401% (minimum 99%, Missing); cerebral cortex: 64.9505% (minimum 99%, Missing); choroid plexus: 73.5426% (minimum 99%, Missing); colon: 75.7506% (minimum 97%, Missing); duodenum: 91.8768% (minimum 99%, Missing); esophagus: 84.3188% (minimum 97%, Missing); heart muscle: 80.3922% (minimum 99%, Missing); hippocampal formation: 64.8221% (minimum 99%, Missing); hypothalamus: 70.9957% (minimum 99%, Missing); kidney: 83.6735% (minimum 99%, Missing); liver: 90.8587% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 87.4667% (minimum 97%, Missing); midbrain: 62.0038% (minimum 99%, Missing); pancreas: 81.7955% (minimum 99%, Missing); parathyroid gland: 71.9298% (minimum 97%, Missing); pituitary gland: 86.3158% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 78.0952% (minimum 99%, Missing); salivary gland: 85.1948% (minimum 97%, Missing); skeletal muscle: 69.0526% (minimum 99%, Missing); skin: 81.7955% (minimum 95%, Missing); small intestine: 87.9357% (minimum 99%, Missing); smooth muscle: 78.0952% (minimum 99%, Missing); spinal cord: 47.7438% (minimum 99%, Missing); spleen: 82.4121% (minimum 95%, Missing); stomach: 82.0000% (minimum 97%, Missing); thymus: 89.6175% (minimum 95%, Missing); thyroid gland: 84.1026% (minimum 95%, Missing); tongue: 69.9360% (minimum 97%, Missing); urinary bladder: 79.0361% (minimum 97%, Missing)",0,1,partial,35.9,14.1,10.2,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 2); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 2); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 2); adipose tissue: 10.2 nTPM (manageable, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 2); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pancreas: 7.3 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); esophagus: 6.1 nTPM (protected, limit 2); salivary gland: 5.7 nTPM (protected, limit 2); pituitary gland: 5.2 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000083290,ULK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.187209,-0.27064,-0.512562
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.6,4.3,4.9,"parathyroid gland: 4.3 nTPM (protected, limit 2); retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); basal ganglia: 2.3 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000083817,ZNF416,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.1818% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.1642% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.1765% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.3803% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.6923% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.1818% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.2857% (minimum 99%, Baseline (adaptation disabled)); colon: 67.1642% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.5862% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.2105% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.3803% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.7705% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.2857% (minimum 99%, Baseline (adaptation disabled)); liver: 69.2308% (minimum 99%, Baseline (adaptation disabled)); lung: 65.2174% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.9474% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.5862% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.1364% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.2308% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.2308% (minimum 97%, Baseline (adaptation disabled)); retina: 55.5556% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.1818% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 64.2857% (minimum 99%, Baseline (adaptation disabled)); skin: 47.8723% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.7705% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.3571% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.1818% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.5714% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.2500% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.8108% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.1765% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.6,4.3,4.9,"parathyroid gland: 4.3 nTPM (protected, limit 2); retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); basal ganglia: 2.3 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000083817,ZNF416,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.471277,-0.458636,-0.434444
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.1818% (minimum 95%, Missing); adrenal gland: 67.1642% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 66.1765% (minimum 99%, Missing); bone marrow: 63.3803% (minimum 99%, Missing); cerebellum: 57.6923% (minimum 99%, Missing); cerebral cortex: 68.1818% (minimum 99%, Missing); choroid plexus: 64.2857% (minimum 99%, Missing); colon: 67.1642% (minimum 97%, Missing); duodenum: 77.5862% (minimum 99%, Missing); esophagus: 59.2105% (minimum 97%, Missing); heart muscle: 63.3803% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 73.7705% (minimum 99%, Missing); kidney: 64.2857% (minimum 99%, Missing); liver: 69.2308% (minimum 99%, Missing); lung: 65.2174% (minimum 99%, Missing); lymph node: 62.5000% (minimum 97%, Missing); midbrain: 78.9474% (minimum 99%, Missing); pancreas: 77.5862% (minimum 99%, Missing); parathyroid gland: 51.1364% (minimum 97%, Missing); pituitary gland: 69.2308% (minimum 99%, Missing); rectum: 69.2308% (minimum 97%, Missing); retina: 55.5556% (minimum 99%, Missing); salivary gland: 68.1818% (minimum 97%, Missing); skeletal muscle: 64.2857% (minimum 99%, Missing); skin: 47.8723% (minimum 95%, Missing); small intestine: 73.7705% (minimum 99%, Missing); smooth muscle: 62.5000% (minimum 99%, Missing); spinal cord: 80.3571% (minimum 99%, Missing); spleen: 62.5000% (minimum 95%, Missing); stomach: 68.1818% (minimum 97%, Missing); thymus: 53.5714% (minimum 95%, Missing); thyroid gland: 56.2500% (minimum 95%, Missing); tongue: 60.8108% (minimum 97%, Missing); urinary bladder: 66.1765% (minimum 97%, Missing)",0,80,unavailable,3.6,4.3,4.9,"parathyroid gland: 4.3 nTPM (protected, limit 2); retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); basal ganglia: 2.3 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000083817,ZNF416,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.471277,-0.458636,-0.434444
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.5,7.1,8,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); spleen: 8 nTPM (manageable, limit 5); pancreas: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); thyroid gland: 7.1 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 2); lymph node: 6.9 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); smooth muscle: 5 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); urinary bladder: 4.3 nTPM (protected, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); cerebellum: 3.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000083844,ZNF264,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9355% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.5652% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.3559% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.6885% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.5455% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 71.6418% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.1905% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.5906% (minimum 99%, Baseline (adaptation disabled)); colon: 71.6418% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.6056% (minimum 99%, Baseline (adaptation disabled)); esophagus: 67.1329% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.6885% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.3388% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 65.3061% (minimum 99%, Baseline (adaptation disabled)); lung: 65.3061% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.1818% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.1724% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.7595% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.0647% (minimum 97%, Baseline (adaptation disabled)); retina: 53.0387% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.7534% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 72.1805% (minimum 99%, Baseline (adaptation disabled)); skin: 59.2593% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.8649% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.7534% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.8000% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.5455% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.4850% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.4913% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.4850% (minimum 95%, Baseline (adaptation disabled)); tongue: 71.6418% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.0647% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.5,7.1,8,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); spleen: 8 nTPM (manageable, limit 5); pancreas: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); thyroid gland: 7.1 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 2); lymph node: 6.9 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); smooth muscle: 5 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); urinary bladder: 4.3 nTPM (protected, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); cerebellum: 3.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000083844,ZNF264,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.404545,-0.39515,-0.459613
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9355% (minimum 95%, Missing); adrenal gland: 69.5652% (minimum 99%, Missing); amygdala: 81.3559% (minimum 99%, Missing); basal ganglia: 78.6885% (minimum 99%, Missing); bone marrow: 54.5455% (minimum 99%, Missing); cerebellum: 71.6418% (minimum 99%, Missing); cerebral cortex: 76.1905% (minimum 99%, Missing); choroid plexus: 75.5906% (minimum 99%, Missing); colon: 71.6418% (minimum 97%, Missing); duodenum: 67.6056% (minimum 99%, Missing); esophagus: 67.1329% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); hippocampal formation: 78.6885% (minimum 99%, Missing); hypothalamus: 79.3388% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 65.3061% (minimum 99%, Missing); lung: 65.3061% (minimum 99%, Missing); lymph node: 58.1818% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 55.1724% (minimum 99%, Missing); parathyroid gland: 60.7595% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 69.0647% (minimum 97%, Missing); retina: 53.0387% (minimum 99%, Missing); salivary gland: 65.7534% (minimum 97%, Missing); skeletal muscle: 72.1805% (minimum 99%, Missing); skin: 59.2593% (minimum 95%, Missing); small intestine: 64.8649% (minimum 99%, Missing); smooth muscle: 65.7534% (minimum 99%, Missing); spinal cord: 76.8000% (minimum 99%, Missing); spleen: 54.5455% (minimum 95%, Missing); stomach: 57.4850% (minimum 97%, Missing); thymus: 55.4913% (minimum 95%, Missing); thyroid gland: 57.4850% (minimum 95%, Missing); tongue: 71.6418% (minimum 97%, Missing); urinary bladder: 69.0647% (minimum 97%, Missing)",0,80,unavailable,8.5,7.1,8,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); spleen: 8 nTPM (manageable, limit 5); pancreas: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); thyroid gland: 7.1 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 2); lymph node: 6.9 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); smooth muscle: 5 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); urinary bladder: 4.3 nTPM (protected, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); cerebellum: 3.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000083844,ZNF264,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.404545,-0.39515,-0.459613
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,21.7,48.3,27.7,"parathyroid gland: 48.3 nTPM (protected, limit 2); thyroid gland: 27.7 nTPM (manageable, limit 5); kidney: 21.7 nTPM (vital, limit 1); salivary gland: 20.6 nTPM (protected, limit 2); skin: 19.9 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 2); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 2); thymus: 15.1 nTPM (manageable, limit 5); choroid plexus: 14.5 nTPM (vital, limit 1); pancreas: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 2); smooth muscle: 14.1 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 2); rectum: 11.1 nTPM (protected, limit 2); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 2); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (manageable, limit 5); spleen: 8.3 nTPM (manageable, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000084693,AGBL5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 92.0393% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.2487% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.0513% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.3234% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.0969% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.9037% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.8147% (minimum 99%, Baseline (adaptation disabled)); colon: 92.3115% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.6100% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.3659% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.8847% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.6959% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.2982% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.6172% (minimum 99%, Baseline (adaptation disabled)); liver: 96.3973% (minimum 99%, Baseline (adaptation disabled)); lung: 94.5482% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.7395% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.3973% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.8147% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.4992% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.8847% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.4052% (minimum 97%, Baseline (adaptation disabled)); retina: 92.2206% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.0914% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.4967% (minimum 99%, Baseline (adaptation disabled)); skin: 90.3958% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.1244% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.9990% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.4470% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.2627% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.5395% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.1163% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.7459% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.8607% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,21.7,48.3,27.7,"parathyroid gland: 48.3 nTPM (protected, limit 2); thyroid gland: 27.7 nTPM (manageable, limit 5); kidney: 21.7 nTPM (vital, limit 1); salivary gland: 20.6 nTPM (protected, limit 2); skin: 19.9 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 2); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 2); thymus: 15.1 nTPM (manageable, limit 5); choroid plexus: 14.5 nTPM (vital, limit 1); pancreas: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 2); smooth muscle: 14.1 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 2); rectum: 11.1 nTPM (protected, limit 2); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 2); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (manageable, limit 5); spleen: 8.3 nTPM (manageable, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000084693,AGBL5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0788372,-0.175008,-0.0938278
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 92.0393% (minimum 99%, Missing); amygdala: 96.2487% (minimum 99%, Missing); basal ganglia: 96.0513% (minimum 99%, Missing); bone marrow: 93.3234% (minimum 99%, Missing); cerebellum: 97.0969% (minimum 99%, Missing); cerebral cortex: 95.9037% (minimum 99%, Missing); choroid plexus: 92.8147% (minimum 99%, Missing); colon: 92.3115% (minimum 97%, Missing); duodenum: 95.6100% (minimum 99%, Missing); esophagus: 91.3659% (minimum 97%, Missing); heart muscle: 93.8847% (minimum 99%, Missing); hippocampal formation: 96.6959% (minimum 99%, Missing); hypothalamus: 96.2982% (minimum 99%, Missing); kidney: 89.6172% (minimum 99%, Missing); liver: 96.3973% (minimum 99%, Missing); lung: 94.5482% (minimum 99%, Missing); lymph node: 94.7395% (minimum 97%, Missing); midbrain: 96.3973% (minimum 99%, Missing); pancreas: 92.8147% (minimum 99%, Missing); parathyroid gland: 79.4992% (minimum 97%, Missing); pituitary gland: 93.8847% (minimum 99%, Missing); rectum: 94.4052% (minimum 97%, Missing); retina: 92.2206% (minimum 99%, Missing); salivary gland: 90.0914% (minimum 97%, Missing); skeletal muscle: 96.4967% (minimum 99%, Missing); skin: 90.3958% (minimum 95%, Missing); small intestine: 95.1244% (minimum 99%, Missing); smooth muscle: 92.9990% (minimum 99%, Uncertain); spinal cord: 96.4470% (minimum 99%, Missing); stomach: 94.2627% (minimum 97%, Missing); thymus: 92.5395% (minimum 95%, Missing); thyroid gland: 87.1163% (minimum 95%, Missing); tongue: 96.7459% (minimum 97%, Missing); urinary bladder: 92.8607% (minimum 97%, Missing)",0,2,partial,21.7,48.3,27.7,"parathyroid gland: 48.3 nTPM (protected, limit 2); thyroid gland: 27.7 nTPM (manageable, limit 5); kidney: 21.7 nTPM (vital, limit 1); salivary gland: 20.6 nTPM (protected, limit 2); skin: 19.9 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 2); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 2); thymus: 15.1 nTPM (manageable, limit 5); choroid plexus: 14.5 nTPM (vital, limit 1); pancreas: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 2); smooth muscle: 14.1 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 2); rectum: 11.1 nTPM (protected, limit 2); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 2); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (manageable, limit 5); spleen: 8.3 nTPM (manageable, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000084693,AGBL5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0788372,-0.175008,-0.0938278
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,28.6,6.5,11.3,"bone marrow: 28.6 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); lymph node: 6.5 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); esophagus: 2.7 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000085840,ORC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.5926% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.2857% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.0392% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0392% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 14.8810% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.2857% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.3396% (minimum 99%, Baseline (adaptation disabled)); colon: 60.2410% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.7576% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.9351% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.0392% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1538% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.9091% (minimum 99%, Baseline (adaptation disabled)); liver: 89.2857% (minimum 99%, Baseline (adaptation disabled)); lung: 89.2857% (minimum 99%, Baseline (adaptation disabled)); lymph node: 43.4783% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.0392% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.3396% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.1538% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.3396% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.1798% (minimum 97%, Baseline (adaptation disabled)); retina: 83.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.2857% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.9091% (minimum 99%, Baseline (adaptation disabled)); skin: 72.4638% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.4932% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.7458% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.1538% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.4638% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 30.6748% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.3396% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 84.7458% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,28.6,6.5,11.3,"bone marrow: 28.6 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); lymph node: 6.5 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); esophagus: 2.7 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000085840,ORC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.643252,-0.535217,-0.84119
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.5926% (minimum 95%, Missing); adrenal gland: 89.2857% (minimum 99%, Missing); amygdala: 98.0392% (minimum 99%, Missing); basal ganglia: 98.0392% (minimum 99%, Missing); bone marrow: 14.8810% (minimum 99%, Missing); cerebellum: 89.2857% (minimum 99%, Missing); cerebral cortex: 94.3396% (minimum 99%, Missing); colon: 60.2410% (minimum 97%, Missing); duodenum: 75.7576% (minimum 99%, Missing); esophagus: 64.9351% (minimum 97%, Missing); heart muscle: 96.1538% (minimum 99%, Missing); hippocampal formation: 98.0392% (minimum 99%, Missing); hypothalamus: 96.1538% (minimum 99%, Missing); kidney: 90.9091% (minimum 99%, Missing); liver: 89.2857% (minimum 99%, Missing); lung: 89.2857% (minimum 99%, Missing); lymph node: 43.4783% (minimum 97%, Missing); midbrain: 98.0392% (minimum 99%, Missing); pancreas: 94.3396% (minimum 99%, Missing); parathyroid gland: 96.1538% (minimum 97%, Missing); pituitary gland: 94.3396% (minimum 99%, Missing); rectum: 56.1798% (minimum 97%, Missing); retina: 83.3333% (minimum 99%, Missing); salivary gland: 89.2857% (minimum 95%, Approved); skeletal muscle: 90.9091% (minimum 99%, Missing); skin: 72.4638% (minimum 95%, Missing); small intestine: 68.4932% (minimum 99%, Missing); smooth muscle: 84.7458% (minimum 99%, Missing); spinal cord: 96.1538% (minimum 99%, Missing); spleen: 72.4638% (minimum 90%, Approved); stomach: 83.3333% (minimum 97%, Missing); thymus: 30.6748% (minimum 95%, Missing); thyroid gland: 94.3396% (minimum 95%, Missing); urinary bladder: 84.7458% (minimum 97%, Missing)",0,5,partial,28.6,6.5,11.3,"bone marrow: 28.6 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); lymph node: 6.5 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); esophagus: 2.7 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000085840,ORC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.643252,-0.535217,-0.84119
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,8.6,5.4,15,"thymus: 15 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); esophagus: 5.2 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000085999,RAD54L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.5975% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.6829% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.4233% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.8655% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.3933% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.8889% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.8153% (minimum 99%, Baseline (adaptation disabled)); colon: 83.0601% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.5098% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.5975% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.4762% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.1212% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.5663% (minimum 99%, Baseline (adaptation disabled)); liver: 96.8153% (minimum 99%, Baseline (adaptation disabled)); lung: 93.2515% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.7864% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.4118% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.8153% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.4359% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.1574% (minimum 97%, Baseline (adaptation disabled)); retina: 97.4359% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.4099% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.2515% (minimum 99%, Baseline (adaptation disabled)); skin: 87.3563% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.9162% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.9408% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.2834% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.9162% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.0180% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.3311% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.4118% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.0000% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,8.6,5.4,15,"thymus: 15 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); esophagus: 5.2 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000085999,RAD54L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.446689,-0.232136,-0.351345
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.5975% (minimum 99%, Missing); amygdala: 92.6829% (minimum 99%, Missing); basal ganglia: 80.4233% (minimum 99%, Missing); bone marrow: 63.8655% (minimum 99%, Missing); cerebellum: 85.3933% (minimum 99%, Missing); cerebral cortex: 88.8889% (minimum 99%, Missing); choroid plexus: 96.8153% (minimum 99%, Missing); colon: 83.0601% (minimum 97%, Missing); duodenum: 88.8889% (minimum 99%, Missing); esophagus: 74.5098% (minimum 97%, Missing); heart muscle: 95.5975% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 92.1212% (minimum 99%, Missing); kidney: 91.5663% (minimum 99%, Missing); liver: 96.8153% (minimum 99%, Missing); lung: 93.2515% (minimum 99%, Missing); lymph node: 73.7864% (minimum 97%, Missing); midbrain: 89.4118% (minimum 99%, Missing); pancreas: 96.8153% (minimum 99%, Missing); pituitary gland: 97.4359% (minimum 99%, Missing); rectum: 77.1574% (minimum 97%, Missing); retina: 97.4359% (minimum 99%, Missing); salivary gland: 94.4099% (minimum 97%, Missing); skeletal muscle: 93.2515% (minimum 99%, Missing); skin: 87.3563% (minimum 95%, Missing); small intestine: 84.9162% (minimum 99%, Missing); smooth muscle: 89.9408% (minimum 99%, Missing); spinal cord: 81.2834% (minimum 99%, Missing); spleen: 84.9162% (minimum 95%, Missing); stomach: 91.0180% (minimum 97%, Missing); thymus: 50.3311% (minimum 95%, Missing); thyroid gland: 89.4118% (minimum 95%, Missing); urinary bladder: 95.0000% (minimum 97%, Missing)",0,3,partial,8.6,5.4,15,"thymus: 15 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); esophagus: 5.2 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000085999,RAD54L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.446689,-0.232136,-0.351345
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,14.2,13.9,15.5,"adipose tissue: 15.5 nTPM (manageable, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 2); thyroid gland: 13.6 nTPM (manageable, limit 5); spleen: 13 nTPM (manageable, limit 5); parathyroid gland: 13 nTPM (protected, limit 4); urinary bladder: 12.9 nTPM (protected, limit 4); skeletal muscle: 12.1 nTPM (vital, limit 2); esophagus: 11.6 nTPM (protected, limit 4); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 2); lymph node: 10.1 nTPM (protected, limit 2); choroid plexus: 10 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); colon: 8.9 nTPM (protected, limit 2); midbrain: 8.9 nTPM (vital, limit 1); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 2); stomach: 8.2 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 4); hypothalamus: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000086200,IPO11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3003% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.2703% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.4982% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.2394% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.1905% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.4906% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.9898% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.5325% (minimum 99%, Baseline (adaptation disabled)); colon: 70.0337% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.6364% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.1975% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.4286% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.5085% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.2394% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.3963% (minimum 99%, Baseline (adaptation disabled)); liver: 65.2038% (minimum 99%, Baseline (adaptation disabled)); lung: 73.4982% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.3139% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.0337% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.2329% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.5385% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.1955% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.4777% (minimum 97%, Baseline (adaptation disabled)); retina: 77.3234% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.7241% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.2219% (minimum 99%, Baseline (adaptation disabled)); skin: 70.9898% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.2394% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.2420% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.7483% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.5385% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.7241% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.9739% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.4651% (minimum 95%, Baseline (adaptation disabled)); tongue: 59.9424% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.7211% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,14.2,13.9,15.5,"adipose tissue: 15.5 nTPM (manageable, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 2); thyroid gland: 13.6 nTPM (manageable, limit 5); spleen: 13 nTPM (manageable, limit 5); parathyroid gland: 13 nTPM (protected, limit 2); urinary bladder: 12.9 nTPM (protected, limit 2); skeletal muscle: 12.1 nTPM (vital, limit 1); esophagus: 11.6 nTPM (protected, limit 2); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 2); choroid plexus: 10 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); colon: 8.9 nTPM (protected, limit 2); midbrain: 8.9 nTPM (vital, limit 1); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 2); stomach: 8.2 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 2); hypothalamus: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000086200,IPO11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.376997,-0.370576,-0.395714
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3003% (minimum 95%, Missing); adrenal gland: 70.2703% (minimum 99%, Missing); amygdala: 73.4982% (minimum 99%, Missing); basal ganglia: 73.2394% (minimum 99%, Missing); bone marrow: 76.1905% (minimum 99%, Missing); cerebellum: 78.4906% (minimum 99%, Missing); cerebral cortex: 70.9898% (minimum 99%, Missing); choroid plexus: 67.5325% (minimum 99%, Missing); colon: 70.0337% (minimum 97%, Missing); duodenum: 75.6364% (minimum 99%, Missing); esophagus: 64.1975% (minimum 95%, Approved); heart muscle: 59.4286% (minimum 99%, Missing); hippocampal formation: 70.5085% (minimum 99%, Missing); hypothalamus: 73.2394% (minimum 99%, Missing); kidney: 64.3963% (minimum 99%, Missing); liver: 65.2038% (minimum 99%, Missing); lung: 73.4982% (minimum 99%, Missing); lymph node: 67.3139% (minimum 97%, Missing); midbrain: 70.0337% (minimum 99%, Missing); pancreas: 71.2329% (minimum 99%, Missing); parathyroid gland: 61.5385% (minimum 95%, Approved); pituitary gland: 78.1955% (minimum 99%, Missing); rectum: 71.4777% (minimum 97%, Missing); retina: 77.3234% (minimum 99%, Missing); salivary gland: 71.7241% (minimum 95%, Approved); skeletal muscle: 63.2219% (minimum 98%, Approved); skin: 70.9898% (minimum 95%, Missing); small intestine: 73.2394% (minimum 99%, Missing); smooth muscle: 66.2420% (minimum 98%, Approved); spinal cord: 70.7483% (minimum 99%, Missing); spleen: 61.5385% (minimum 95%, Missing); stomach: 71.7241% (minimum 97%, Missing); thymus: 67.9739% (minimum 95%, Missing); thyroid gland: 60.4651% (minimum 95%, Missing); tongue: 59.9424% (minimum 97%, Missing); urinary bladder: 61.7211% (minimum 95%, Approved)",0,3,partial,14.2,13.9,15.5,"adipose tissue: 15.5 nTPM (manageable, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 2); thyroid gland: 13.6 nTPM (manageable, limit 5); spleen: 13 nTPM (manageable, limit 5); parathyroid gland: 13 nTPM (protected, limit 4); urinary bladder: 12.9 nTPM (protected, limit 4); skeletal muscle: 12.1 nTPM (vital, limit 2); esophagus: 11.6 nTPM (protected, limit 4); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 2); lymph node: 10.1 nTPM (protected, limit 2); choroid plexus: 10 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); colon: 8.9 nTPM (protected, limit 2); midbrain: 8.9 nTPM (vital, limit 1); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 2); stomach: 8.2 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 4); hypothalamus: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000086200,IPO11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.376997,-0.370576,-0.395714
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,12.2,0.5,1,"bone marrow: 12.2 nTPM (vital, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000086288,NME8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 45.2915% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.1154% (minimum 99%, Baseline (adaptation disabled)); lung: 96.1905% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.2830% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.0583% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.0583% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.1905% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.9910% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,12.2,0.5,1,"bone marrow: 12.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000086288,NME8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0400901,-0.0171698,-0.537085
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 45.2915% (minimum 95%, Enhanced); choroid plexus: 97.1154% (minimum 99%, Missing); midbrain: 98.0583% (minimum 99%, Missing); spinal cord: 96.1905% (minimum 99%, Missing)",0,1,partial,12.2,0.5,1,"bone marrow: 12.2 nTPM (vital, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000086288,NME8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0211538,0.03,-0.497085
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,177.1,43.3,29.7,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 2); thyroid gland: 29.7 nTPM (manageable, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 2); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); salivary gland: 7.9 nTPM (protected, limit 2); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); thymus: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (manageable, limit 5); adrenal gland: 5 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000086619,ERO1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.2434% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.7021% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.8706% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.1175% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.7895% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.4292% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.1658% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.5316% (minimum 99%, Baseline (adaptation disabled)); colon: 87.3995% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.2887% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.6136% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.6344% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.9333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.6344% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.2968% (minimum 99%, Baseline (adaptation disabled)); liver: 60.9346% (minimum 99%, Baseline (adaptation disabled)); lung: 87.8706% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.4560% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.3151% (minimum 99%, Baseline (adaptation disabled)); pancreas: 15.5460% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.7258% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.9904% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.5556% (minimum 97%, Baseline (adaptation disabled)); retina: 88.5870% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.4938% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.5730% (minimum 99%, Baseline (adaptation disabled)); skin: 92.3513% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.7021% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.3995% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.7021% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.8933% (minimum 95%, Baseline (adaptation disabled)); stomach: 42.9513% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.6753% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.3274% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.3047% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.1658% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,177.1,43.3,29.7,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 2); thyroid gland: 29.7 nTPM (manageable, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 2); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); salivary gland: 7.9 nTPM (protected, limit 2); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); thymus: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (manageable, limit 5); adrenal gland: 5 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000086619,ERO1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.426726,-0.540487,-0.83454
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.2434% (minimum 95%, Missing); adrenal gland: 86.7021% (minimum 99%, Missing); amygdala: 87.8706% (minimum 99%, Missing); basal ganglia: 85.1175% (minimum 99%, Missing); bone marrow: 85.7895% (minimum 99%, Missing); cerebellum: 74.4292% (minimum 99%, Missing); cerebral cortex: 87.1658% (minimum 99%, Missing); choroid plexus: 82.5316% (minimum 99%, Missing); colon: 87.3995% (minimum 97%, Missing); duodenum: 75.2887% (minimum 99%, Missing); esophagus: 92.6136% (minimum 97%, Missing); heart muscle: 87.6344% (minimum 99%, Missing); hippocampal formation: 86.9333% (minimum 99%, Missing); hypothalamus: 87.6344% (minimum 99%, Missing); kidney: 81.2968% (minimum 99%, Missing); liver: 60.9346% (minimum 99%, Missing); lung: 87.8706% (minimum 99%, Missing); lymph node: 84.4560% (minimum 97%, Missing); midbrain: 89.3151% (minimum 99%, Missing); pancreas: 15.5460% (minimum 99%, Missing); parathyroid gland: 65.7258% (minimum 97%, Missing); pituitary gland: 77.9904% (minimum 99%, Missing); rectum: 90.5556% (minimum 97%, Missing); retina: 88.5870% (minimum 99%, Missing); salivary gland: 80.4938% (minimum 97%, Missing); skeletal muscle: 91.5730% (minimum 99%, Missing); skin: 92.3513% (minimum 95%, Missing); small intestine: 86.7021% (minimum 99%, Missing); smooth muscle: 87.3995% (minimum 99%, Missing); spinal cord: 86.7021% (minimum 99%, Missing); spleen: 80.8933% (minimum 95%, Missing); stomach: 42.9513% (minimum 97%, Missing); thymus: 84.6753% (minimum 95%, Missing); thyroid gland: 52.3274% (minimum 95%, Missing); tongue: 90.3047% (minimum 97%, Missing); urinary bladder: 87.1658% (minimum 97%, Missing)",0,3,partial,177.1,43.3,29.7,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 2); thyroid gland: 29.7 nTPM (manageable, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 2); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); salivary gland: 7.9 nTPM (protected, limit 2); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); thymus: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (manageable, limit 5); adrenal gland: 5 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000086619,ERO1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.426726,-0.540487,-0.83454
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.3,0.2,0.5,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000086717,PPEF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5507% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.5170% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.1049% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.1507% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.5507% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.5322% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.8417% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.8417% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.2752% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.8919% (minimum 99%, Baseline (adaptation disabled)); lung: 97.8417% (minimum 99%, Baseline (adaptation disabled)); midbrain: 88.8889% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.4539% (minimum 99%, Baseline (adaptation disabled)); retina: 90.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.9038% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,10.3,0.2,0.5,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000086717,PPEF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025,0.014539,0.0155072,-0.420962
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5507% (minimum 99%, Missing); amygdala: 92.5170% (minimum 99%, Missing); basal ganglia: 95.1049% (minimum 99%, Missing); bone marrow: 93.1507% (minimum 99%, Missing); cerebellum: 98.5507% (minimum 99%, Missing); cerebral cortex: 79.5322% (minimum 99%, Missing); choroid plexus: 97.8417% (minimum 99%, Missing); heart muscle: 97.8417% (minimum 99%, Missing); hippocampal formation: 91.2752% (minimum 99%, Missing); hypothalamus: 91.8919% (minimum 99%, Missing); lung: 97.8417% (minimum 99%, Missing); midbrain: 88.8889% (minimum 99%, Missing); pituitary gland: 96.4539% (minimum 99%, Missing); retina: 90.6667% (minimum 99%, Missing); spinal cord: 56.9038% (minimum 99%, Missing)",0,80,unavailable,10.3,0.2,0.5,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000086717,PPEF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025,0.014539,0.0155072,-0.420962
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,15.5,18.5,18,"parathyroid gland: 18.5 nTPM (protected, limit 4); thymus: 18 nTPM (manageable, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 2); choroid plexus: 11.7 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 2); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); liver: 10.3 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); spleen: 8.9 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); pancreas: 8.7 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); stomach: 8.3 nTPM (protected, limit 2); urinary bladder: 8 nTPM (protected, limit 2); esophagus: 8 nTPM (protected, limit 2); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000087338,GMCL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.8554% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.9457% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.0766% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.1845% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.0816% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.8312% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.9535% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 57.6087% (minimum 99%, Baseline (adaptation disabled)); colon: 60.4563% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.6369% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.5272% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.5610% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.2991% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.3555% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.8889% (minimum 99%, Baseline (adaptation disabled)); liver: 60.6870% (minimum 99%, Baseline (adaptation disabled)); lung: 67.9487% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.6087% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.9535% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.6341% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 46.2209% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.6216% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.4007% (minimum 97%, Baseline (adaptation disabled)); retina: 72.6027% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.6000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 79.8995% (minimum 99%, Baseline (adaptation disabled)); skin: 65.1639% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.5944% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.2727% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.2991% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.1129% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.7025% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.9027% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.1129% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.3555% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.5272% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,15.5,18.5,18,"parathyroid gland: 18.5 nTPM (protected, limit 2); thymus: 18 nTPM (manageable, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 2); choroid plexus: 11.7 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 2); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); liver: 10.3 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); spleen: 8.9 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); pancreas: 8.7 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); stomach: 8.3 nTPM (protected, limit 2); urinary bladder: 8 nTPM (protected, limit 2); esophagus: 8 nTPM (protected, limit 2); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000087338,GMCL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.480973,-0.507791,-0.483631
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.8554% (minimum 95%, Missing); adrenal gland: 71.9457% (minimum 99%, Missing); amygdala: 76.0766% (minimum 99%, Missing); basal ganglia: 77.1845% (minimum 99%, Missing); bone marrow: 54.0816% (minimum 99%, Missing); cerebellum: 68.8312% (minimum 99%, Missing); cerebral cortex: 73.9535% (minimum 99%, Missing); choroid plexus: 57.6087% (minimum 99%, Missing); colon: 60.4563% (minimum 97%, Missing); duodenum: 50.6369% (minimum 99%, Missing); esophagus: 66.5272% (minimum 97%, Missing); heart muscle: 77.5610% (minimum 99%, Missing); hippocampal formation: 74.2991% (minimum 99%, Missing); hypothalamus: 75.3555% (minimum 99%, Missing); kidney: 58.8889% (minimum 99%, Missing); liver: 60.6870% (minimum 99%, Missing); lung: 67.9487% (minimum 99%, Missing); lymph node: 57.6087% (minimum 97%, Missing); midbrain: 73.9535% (minimum 99%, Missing); pancreas: 64.6341% (minimum 99%, Missing); parathyroid gland: 46.2209% (minimum 95%, Approved); pituitary gland: 71.6216% (minimum 99%, Missing); rectum: 57.4007% (minimum 97%, Missing); retina: 72.6027% (minimum 99%, Missing); salivary gland: 63.6000% (minimum 97%, Missing); skeletal muscle: 79.8995% (minimum 99%, Missing); skin: 65.1639% (minimum 95%, Missing); small intestine: 55.5944% (minimum 99%, Missing); smooth muscle: 72.2727% (minimum 99%, Missing); spinal cord: 74.2991% (minimum 99%, Missing); spleen: 64.1129% (minimum 95%, Missing); stomach: 65.7025% (minimum 97%, Missing); thymus: 46.9027% (minimum 95%, Missing); thyroid gland: 64.1129% (minimum 95%, Missing); tongue: 75.3555% (minimum 97%, Missing); urinary bladder: 66.5272% (minimum 97%, Missing)",0,5,partial,15.5,18.5,18,"parathyroid gland: 18.5 nTPM (protected, limit 4); thymus: 18 nTPM (manageable, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 2); choroid plexus: 11.7 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 2); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); liver: 10.3 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); spleen: 8.9 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); pancreas: 8.7 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); stomach: 8.3 nTPM (protected, limit 2); urinary bladder: 8 nTPM (protected, limit 2); esophagus: 8 nTPM (protected, limit 2); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000087338,GMCL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.480973,-0.487791,-0.483631
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,15.1,20.4,19.6,"lymph node: 20.4 nTPM (protected, limit 2); thymus: 19.6 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 2); duodenum: 11.6 nTPM (vital, limit 6); colon: 10.4 nTPM (protected, limit 2); small intestine: 9 nTPM (vital, limit 6); skeletal muscle: 8.4 nTPM (vital, limit 6); tongue: 7.9 nTPM (protected, limit 2); esophagus: 7.3 nTPM (protected, limit 2); liver: 4.9 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000087586,AURKA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.8571% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.0779% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.4516% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.4444% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.4516% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.4516% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.0328% (minimum 99%, Baseline (adaptation disabled)); colon: 74.1935% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.0482% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.3763% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.4286% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.0779% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.0779% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.1464% (minimum 99%, Baseline (adaptation disabled)); liver: 85.9195% (minimum 99%, Baseline (adaptation disabled)); lung: 93.4375% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.4433% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.5272% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.7304% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.6203% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.0328% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.5189% (minimum 97%, Baseline (adaptation disabled)); retina: 91.1585% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.0252% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.0679% (minimum 99%, Baseline (adaptation disabled)); skin: 90.0602% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.8638% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.1671% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.1415% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.4286% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.4162% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.4040% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.1005% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 91.1585% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,15.1,20.4,19.6,"lymph node: 20.4 nTPM (protected, limit 2); thymus: 19.6 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 2); duodenum: 11.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); small intestine: 9 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 2); esophagus: 7.3 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); spleen: 5.1 nTPM (manageable, limit 5); liver: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000087586,AURKA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.34596,-0.375567,-0.325556
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.8571% (minimum 95%, Enhanced); amygdala: 97.0779% (minimum 99%, Missing); basal ganglia: 96.4516% (minimum 99%, Missing); bone marrow: 66.4444% (minimum 99%, Missing); choroid plexus: 98.0328% (minimum 99%, Missing); colon: 74.1935% (minimum 97%, Missing); duodenum: 72.0482% (minimum 95%, Enhanced); esophagus: 80.3763% (minimum 97%, Missing); heart muscle: 85.4286% (minimum 95%, Enhanced); hippocampal formation: 97.0779% (minimum 99%, Missing); hypothalamus: 97.0779% (minimum 99%, Missing); kidney: 93.1464% (minimum 99%, Missing); liver: 85.9195% (minimum 99%, Missing); lung: 93.4375% (minimum 99%, Missing); lymph node: 59.4433% (minimum 97%, Missing); midbrain: 95.5272% (minimum 99%, Missing); pancreas: 93.7304% (minimum 95%, Enhanced); pituitary gland: 98.0328% (minimum 99%, Missing); rectum: 70.5189% (minimum 97%, Missing); retina: 91.1585% (minimum 99%, Missing); skeletal muscle: 78.0679% (minimum 95%, Enhanced); small intestine: 76.8638% (minimum 95%, Enhanced); smooth muscle: 86.1671% (minimum 95%, Enhanced); spinal cord: 96.1415% (minimum 99%, Missing); stomach: 86.4162% (minimum 97%, Missing); thymus: 60.4040% (minimum 95%, Missing); tongue: 79.1005% (minimum 97%, Missing); urinary bladder: 91.1585% (minimum 97%, Missing)",0,3,partial,15.1,20.4,19.6,"lymph node: 20.4 nTPM (protected, limit 2); thymus: 19.6 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 2); duodenum: 11.6 nTPM (vital, limit 6); colon: 10.4 nTPM (protected, limit 2); small intestine: 9 nTPM (vital, limit 6); skeletal muscle: 8.4 nTPM (vital, limit 6); tongue: 7.9 nTPM (protected, limit 2); esophagus: 7.3 nTPM (protected, limit 2); liver: 4.9 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000087586,AURKA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.34596,-0.375567,-0.325556
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,47.4,25.9,68.5,"thymus: 68.5 nTPM (manageable, limit 5); bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 2); rectum: 13.8 nTPM (protected, limit 2); esophagus: 12.8 nTPM (protected, limit 2); colon: 11.3 nTPM (protected, limit 2); skin: 9.6 nTPM (manageable, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); liver: 4.1 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000088325,TPX2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 94.0063% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.5128% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.0263% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.7532% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.6010% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.4401% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.3038% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7049% (minimum 99%, Baseline (adaptation disabled)); colon: 72.5061% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.4103% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.9531% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.7049% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.0263% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.3498% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.7049% (minimum 99%, Baseline (adaptation disabled)); liver: 87.9056% (minimum 99%, Baseline (adaptation disabled)); lung: 94.0063% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.5009% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.3498% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6755% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.3486% (minimum 97%, Baseline (adaptation disabled)); retina: 98.3498% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.7107% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.8199% (minimum 99%, Baseline (adaptation disabled)); skin: 75.6345% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.6067% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.0937% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.3498% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.3868% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.2402% (minimum 97%, Baseline (adaptation disabled)); thymus: 30.3154% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 90.0302% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,47.4,25.9,68.5,"thymus: 68.5 nTPM (manageable, limit 5); bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 2); rectum: 13.8 nTPM (protected, limit 2); esophagus: 12.8 nTPM (protected, limit 2); colon: 11.3 nTPM (protected, limit 2); skin: 9.6 nTPM (manageable, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); spleen: 5.1 nTPM (manageable, limit 5); liver: 4.1 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000088325,TPX2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.646846,-0.434991,-0.60399
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.5128% (minimum 99%, Missing); amygdala: 98.0263% (minimum 99%, Missing); basal ganglia: 96.7532% (minimum 99%, Missing); bone marrow: 38.6010% (minimum 99%, Missing); cerebellum: 96.4401% (minimum 99%, Missing); cerebral cortex: 94.3038% (minimum 99%, Missing); choroid plexus: 97.7049% (minimum 99%, Missing); colon: 72.5061% (minimum 97%, Missing); duodenum: 76.4103% (minimum 99%, Missing); esophagus: 69.9531% (minimum 97%, Missing); hippocampal formation: 98.0263% (minimum 99%, Missing); hypothalamus: 98.3498% (minimum 99%, Missing); kidney: 97.7049% (minimum 99%, Missing); liver: 87.9056% (minimum 99%, Missing); lung: 94.0063% (minimum 99%, Missing); lymph node: 53.5009% (minimum 97%, Missing); midbrain: 98.3498% (minimum 99%, Missing); pancreas: 98.6755% (minimum 99%, Missing); rectum: 68.3486% (minimum 97%, Missing); retina: 98.3498% (minimum 99%, Missing); skeletal muscle: 95.8199% (minimum 99%, Missing); skin: 75.6345% (minimum 95%, Missing); small intestine: 76.6067% (minimum 99%, Missing); smooth muscle: 82.0937% (minimum 99%, Missing); spinal cord: 98.3498% (minimum 99%, Missing); stomach: 83.2402% (minimum 97%, Missing); thymus: 30.3154% (minimum 95%, Missing); urinary bladder: 90.0302% (minimum 97%, Missing)",0,6,partial,47.4,25.9,68.5,"thymus: 68.5 nTPM (manageable, limit 5); bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 2); rectum: 13.8 nTPM (protected, limit 2); esophagus: 12.8 nTPM (protected, limit 2); colon: 11.3 nTPM (protected, limit 2); skin: 9.6 nTPM (manageable, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); liver: 4.1 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000088325,TPX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.646846,-0.434991,-0.60399
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,110.4,9.7,20.3,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (manageable, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 2); spinal cord: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); salivary gland: 8.7 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 2); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 2); adipose tissue: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 2); spleen: 5.5 nTPM (manageable, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000088727,KIF9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.3462% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.2307% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.6478% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.1472% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.0384% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.5302% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.7531% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 37.5919% (minimum 99%, Baseline (adaptation disabled)); colon: 88.3134% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.8508% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.1053% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.9177% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.0384% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.3256% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.8143% (minimum 99%, Baseline (adaptation disabled)); liver: 91.9779% (minimum 99%, Baseline (adaptation disabled)); lung: 88.7850% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.3768% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.9786% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.2839% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.2703% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.6061% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.5020% (minimum 97%, Baseline (adaptation disabled)); retina: 78.4198% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.4309% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.9630% (minimum 99%, Baseline (adaptation disabled)); skin: 89.0228% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.4896% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.7941% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.8468% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.3611% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.9630% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 76.6129% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.4896% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.9713% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,110.4,9.7,20.3,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (manageable, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 2); spinal cord: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); salivary gland: 8.7 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 2); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 2); adipose tissue: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 2); spleen: 5.5 nTPM (manageable, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000088727,KIF9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.183871,-0.0972966,-0.614081
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.3462% (minimum 95%, Missing); adrenal gland: 90.2307% (minimum 99%, Missing); amygdala: 83.6478% (minimum 99%, Missing); basal ganglia: 85.1472% (minimum 99%, Missing); bone marrow: 85.0384% (minimum 99%, Missing); cerebellum: 93.5302% (minimum 99%, Missing); cerebral cortex: 83.7531% (minimum 99%, Missing); choroid plexus: 37.5919% (minimum 99%, Missing); colon: 88.3134% (minimum 97%, Missing); duodenum: 91.8508% (minimum 99%, Missing); esophagus: 92.1053% (minimum 97%, Missing); heart muscle: 82.9177% (minimum 99%, Missing); hippocampal formation: 85.0384% (minimum 99%, Missing); hypothalamus: 77.3256% (minimum 99%, Missing); kidney: 71.8143% (minimum 99%, Missing); liver: 91.9779% (minimum 99%, Missing); lung: 88.7850% (minimum 99%, Missing); lymph node: 96.3768% (minimum 97%, Missing); midbrain: 78.9786% (minimum 99%, Missing); pancreas: 84.2839% (minimum 99%, Missing); parathyroid gland: 87.2703% (minimum 97%, Missing); pituitary gland: 80.6061% (minimum 99%, Missing); rectum: 89.5020% (minimum 97%, Missing); retina: 78.4198% (minimum 99%, Missing); salivary gland: 88.4309% (minimum 97%, Missing); skeletal muscle: 87.9630% (minimum 99%, Missing); skin: 89.0228% (minimum 95%, Missing); small intestine: 92.4896% (minimum 99%, Missing); smooth muscle: 93.7941% (minimum 99%, Missing); spinal cord: 87.8468% (minimum 99%, Missing); spleen: 92.3611% (minimum 95%, Missing); stomach: 87.9630% (minimum 97%, Missing); thyroid gland: 76.6129% (minimum 95%, Missing); tongue: 92.4896% (minimum 97%, Missing); urinary bladder: 90.9713% (minimum 97%, Missing)",0,0,routine_complete,110.4,9.7,20.3,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (manageable, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 2); spinal cord: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); salivary gland: 8.7 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 2); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 2); adipose tissue: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 2); spleen: 5.5 nTPM (manageable, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000088727,KIF9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.183871,-0.0972966,-0.614081
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,8.1,5.2,12.3,"kidney: 8.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000088756,ARHGAP28,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.2284% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.5325% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.9460% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.7865% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.5325% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.2644% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8158% (minimum 99%, Baseline (adaptation disabled)); lung: 94.4654% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.3046% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.1588% (minimum 97%, Baseline (adaptation disabled)); retina: 98.1699% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 93.9925% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.7865% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.2984% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9460% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.9268% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.5243% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,8.1,5.2,12.3,"spleen: 12.3 nTPM (manageable, limit 5); kidney: 8.1 nTPM (vital, limit 1); urinary bladder: 5.2 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); stomach: 2.1 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000088756,ARHGAP28,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0907323,-0.0347572,-0.0873558
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.5325% (minimum 99%, Missing); heart muscle: 97.5325% (minimum 99%, Missing); kidney: 90.2644% (minimum 99%, Missing); lung: 94.4654% (minimum 99%, Missing); pancreas: 95.3046% (minimum 99%, Missing); retina: 98.1699% (minimum 99%, Missing); skeletal muscle: 93.9925% (minimum 99%, Missing); spinal cord: 98.9460% (minimum 99%, Missing)",0,4,partial,8.1,5.2,12.3,"kidney: 8.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000088756,ARHGAP28,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.00304569,0.00659298,-0.0873558
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000088782,DEFB127,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000088782,DEFB127,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00990484
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000088782,DEFB127,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00990484
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,33.2,13.4,12.5,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 2); thymus: 12.5 nTPM (manageable, limit 5); skin: 12.4 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 2); parathyroid gland: 10.2 nTPM (protected, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); liver: 9.7 nTPM (vital, limit 1); heart muscle: 9.3 nTPM (vital, limit 1); colon: 9.2 nTPM (protected, limit 2); esophagus: 9.2 nTPM (protected, limit 2); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); urinary bladder: 8.9 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); duodenum: 8.9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.6 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 2); kidney: 8.2 nTPM (vital, limit 1); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); stomach: 7.5 nTPM (protected, limit 2); basal ganglia: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000089234,BRAP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5335% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.3627% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.9449% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.8212% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.2944% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.0859% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.7688% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.8869% (minimum 99%, Baseline (adaptation disabled)); colon: 87.6510% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.0054% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.6510% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.5335% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.1934% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.1934% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.8435% (minimum 99%, Baseline (adaptation disabled)); liver: 87.0667% (minimum 99%, Baseline (adaptation disabled)); lung: 89.3297% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.3757% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.3297% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.2077% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.4901% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.5849% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.0054% (minimum 97%, Baseline (adaptation disabled)); retina: 88.0054% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.8435% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.3697% (minimum 99%, Baseline (adaptation disabled)); skin: 84.0412% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.3627% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.8869% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.9646% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.1242% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.6978% (minimum 97%, Baseline (adaptation disabled)); thymus: 83.9332% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.0667% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.9733% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.0054% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,33.2,13.4,12.5,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 2); thymus: 12.5 nTPM (manageable, limit 5); skin: 12.4 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 2); parathyroid gland: 10.2 nTPM (protected, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); liver: 9.7 nTPM (vital, limit 1); heart muscle: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); esophagus: 9.2 nTPM (protected, limit 2); colon: 9.2 nTPM (protected, limit 2); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); rectum: 8.9 nTPM (protected, limit 2); urinary bladder: 8.9 nTPM (protected, limit 2); duodenum: 8.9 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.6 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 2); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); stomach: 7.5 nTPM (protected, limit 2); basal ganglia: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000089234,BRAP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.110668,-0.140267,-0.327056
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5335% (minimum 90%, Approved); adrenal gland: 88.3627% (minimum 99%, Missing); amygdala: 89.9449% (minimum 99%, Missing); basal ganglia: 89.8212% (minimum 99%, Missing); bone marrow: 66.2944% (minimum 99%, Missing); cerebellum: 89.0859% (minimum 99%, Missing); cerebral cortex: 87.7688% (minimum 99%, Missing); choroid plexus: 87.8869% (minimum 99%, Missing); colon: 87.6510% (minimum 97%, Missing); duodenum: 88.0054% (minimum 99%, Missing); esophagus: 87.6510% (minimum 97%, Missing); heart muscle: 87.5335% (minimum 99%, Missing); hippocampal formation: 90.1934% (minimum 99%, Missing); hypothalamus: 90.1934% (minimum 99%, Missing); kidney: 88.8435% (minimum 99%, Missing); liver: 87.0667% (minimum 99%, Missing); lung: 89.3297% (minimum 99%, Missing); lymph node: 86.3757% (minimum 97%, Missing); midbrain: 89.3297% (minimum 99%, Missing); pancreas: 89.2077% (minimum 99%, Missing); parathyroid gland: 86.4901% (minimum 97%, Missing); pituitary gland: 91.5849% (minimum 99%, Missing); rectum: 88.0054% (minimum 97%, Missing); retina: 88.0054% (minimum 99%, Missing); salivary gland: 88.8435% (minimum 97%, Missing); skeletal muscle: 77.3697% (minimum 99%, Missing); skin: 84.0412% (minimum 95%, Missing); small intestine: 88.3627% (minimum 99%, Missing); smooth muscle: 87.8869% (minimum 99%, Missing); spinal cord: 88.9646% (minimum 99%, Missing); spleen: 88.1242% (minimum 95%, Missing); stomach: 89.6978% (minimum 97%, Missing); thymus: 83.9332% (minimum 95%, Missing); thyroid gland: 87.0667% (minimum 95%, Missing); tongue: 82.9733% (minimum 97%, Missing); urinary bladder: 88.0054% (minimum 97%, Missing)",0,4,partial,33.2,13.4,12.5,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 2); thymus: 12.5 nTPM (manageable, limit 5); skin: 12.4 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 2); parathyroid gland: 10.2 nTPM (protected, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); liver: 9.7 nTPM (vital, limit 1); heart muscle: 9.3 nTPM (vital, limit 1); colon: 9.2 nTPM (protected, limit 2); esophagus: 9.2 nTPM (protected, limit 2); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); urinary bladder: 8.9 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); duodenum: 8.9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.6 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 2); kidney: 8.2 nTPM (vital, limit 1); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); stomach: 7.5 nTPM (protected, limit 2); basal ganglia: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000089234,BRAP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.110668,-0.140267,-0.327056
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.3,1.6,3.1,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000089505,CMTM1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.8153% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.1246% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.8153% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.9664% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.5975% (minimum 99%, Baseline (adaptation disabled)); colon: 96.2025% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.1176% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.3819% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.1246% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.5079% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.4359% (minimum 99%, Baseline (adaptation disabled)); liver: 98.3819% (minimum 99%, Baseline (adaptation disabled)); lung: 96.2025% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.4359% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7492% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.5079% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.4359% (minimum 99%, Baseline (adaptation disabled)); retina: 97.1246% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.8153% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.7013% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.2978% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.0645% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.8153% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.7463% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.2025% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.1212% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2.3,1.6,3.1,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000089505,CMTM1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.0425373,-0.02,-0.0603364
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.8153% (minimum 99%, Missing); amygdala: 97.1246% (minimum 99%, Missing); basal ganglia: 96.8153% (minimum 99%, Missing); cerebellum: 92.9664% (minimum 99%, Missing); cerebral cortex: 95.5975% (minimum 99%, Missing); colon: 96.2025% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); heart muscle: 98.3819% (minimum 99%, Missing); hippocampal formation: 97.1246% (minimum 99%, Missing); hypothalamus: 96.5079% (minimum 99%, Missing); kidney: 97.4359% (minimum 99%, Missing); liver: 98.3819% (minimum 99%, Missing); lung: 96.2025% (minimum 99%, Missing); lymph node: 95.0000% (minimum 97%, Missing); midbrain: 97.4359% (minimum 99%, Missing); pancreas: 97.7492% (minimum 99%, Missing); parathyroid gland: 96.5079% (minimum 97%, Missing); pituitary gland: 97.4359% (minimum 99%, Missing); retina: 97.1246% (minimum 99%, Missing); salivary gland: 96.8153% (minimum 97%, Missing); skeletal muscle: 98.7013% (minimum 99%, Missing); small intestine: 95.2978% (minimum 99%, Missing); smooth muscle: 98.0645% (minimum 99%, Missing); spinal cord: 96.8153% (minimum 99%, Missing); spleen: 90.7463% (minimum 95%, Missing); stomach: 96.2025% (minimum 97%, Missing); thymus: 92.1212% (minimum 95%, Missing)",0,80,unavailable,2.3,1.6,3.1,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000089505,CMTM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.0425373,-0.02,-0.0603364
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,37.4,15.9,39.9,"thymus: 39.9 nTPM (manageable, limit 5); bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 2); esophagus: 12.4 nTPM (protected, limit 2); rectum: 7.7 nTPM (protected, limit 2); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 2); skin: 5.7 nTPM (manageable, limit 5); stomach: 3.6 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000089685,BIRC5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.5274% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.9583% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.9583% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 33.6879% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.4359% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.9596% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.9388% (minimum 99%, Baseline (adaptation disabled)); colon: 74.8031% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.4286% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.5096% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.4359% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.4456% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9583% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.4467% (minimum 99%, Baseline (adaptation disabled)); liver: 90.4762% (minimum 99%, Baseline (adaptation disabled)); lung: 91.3462% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.4413% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.4456% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.9388% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.9583% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.1610% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 91.7874% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 76.9231% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.2433% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.2511% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.9381% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.9231% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.0708% (minimum 97%, Baseline (adaptation disabled)); thymus: 32.2581% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 88.3721% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,37.4,15.9,39.9,"thymus: 39.9 nTPM (manageable, limit 5); bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 2); esophagus: 12.4 nTPM (protected, limit 2); rectum: 7.7 nTPM (protected, limit 2); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 2); skin: 5.7 nTPM (manageable, limit 5); spleen: 5.7 nTPM (manageable, limit 5); smooth muscle: 4.1 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000089685,BIRC5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.627419,-0.425587,-0.653121
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.5274% (minimum 95%, Enhanced); amygdala: 98.9583% (minimum 99%, Missing); basal ganglia: 98.9583% (minimum 99%, Missing); bone marrow: 33.6879% (minimum 99%, Missing); choroid plexus: 96.9388% (minimum 99%, Missing); colon: 74.8031% (minimum 97%, Missing); duodenum: 71.4286% (minimum 99%, Missing); esophagus: 60.5096% (minimum 97%, Missing); hippocampal formation: 98.4456% (minimum 99%, Missing); hypothalamus: 98.9583% (minimum 99%, Missing); liver: 90.4762% (minimum 95%, Enhanced); lung: 91.3462% (minimum 95%, Enhanced); lymph node: 54.4413% (minimum 97%, Missing); midbrain: 98.4456% (minimum 99%, Missing); pituitary gland: 98.9583% (minimum 99%, Missing); rectum: 71.1610% (minimum 97%, Missing); skin: 76.9231% (minimum 95%, Missing); small intestine: 72.2433% (minimum 99%, Missing); smooth muscle: 82.2511% (minimum 95%, Enhanced); spinal cord: 97.9381% (minimum 99%, Missing); stomach: 84.0708% (minimum 97%, Missing); thymus: 32.2581% (minimum 95%, Missing); urinary bladder: 88.3721% (minimum 97%, Missing)",0,7,partial,37.4,15.9,39.9,"thymus: 39.9 nTPM (manageable, limit 5); bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 2); esophagus: 12.4 nTPM (protected, limit 2); rectum: 7.7 nTPM (protected, limit 2); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 2); skin: 5.7 nTPM (manageable, limit 5); stomach: 3.6 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000089685,BIRC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.627419,-0.425587,-0.653121
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,530,30,0,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 2); colon: 17 nTPM (protected, limit 2)",duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),75,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; appendix / enterocytes - Microvilli; lymph node,ENSG00000090402,SI,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 8.6022% (minimum 97%, Baseline (adaptation disabled)); duodenum: 0.3010% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled)); rectum: 5.0633% (minimum 97%, Baseline (adaptation disabled)); small intestine: 0.3657% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); stomach: 72.7273% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,530,30,0,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 2); colon: 17 nTPM (protected, limit 2)",duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),75,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; appendix / enterocytes - Microvilli; lymph node,ENSG00000090402,SI,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,-0.919367,-0.98699
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 8.6022% (minimum 97%, Missing); duodenum: 0.3010% (minimum 99%, Missing); rectum: 5.0633% (minimum 97%, Missing); small intestine: 0.3657% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 95%, Enhanced); stomach: 72.7273% (minimum 80%, Enhanced)",0,6,partial,530,30,0,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 2); colon: 17 nTPM (protected, limit 2)",duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),75,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; appendix / enterocytes - Microvilli; lymph node,ENSG00000090402,SI,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,-0.919367,-0.98699
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,12.4,12.6,10.4,"parathyroid gland: 12.6 nTPM (protected, limit 2); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); kidney: 9 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); stomach: 7 nTPM (protected, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); lymph node: 6 nTPM (protected, limit 4); spleen: 5.8 nTPM (manageable, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); lung: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); salivary gland: 5.4 nTPM (protected, limit 2); rectum: 5.2 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000090612,ZNF268,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 59.3548% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.0331% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.7967% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.4409% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.4409% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.2278% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.2482% (minimum 99%, Baseline (adaptation disabled)); colon: 63.0137% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.1481% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.7403% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.6567% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.6325% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.5495% (minimum 99%, Baseline (adaptation disabled)); liver: 42.5926% (minimum 99%, Baseline (adaptation disabled)); lung: 63.0137% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.5263% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.3103% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.3357% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 42.2018% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.7692% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 44.2308% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.0137% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 64.7887% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.7887% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.1622% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.6325% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.7901% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.4417% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 46.9388% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.1871% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.1307% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,12.4,12.6,10.4,"parathyroid gland: 12.6 nTPM (protected, limit 2); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); kidney: 9 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); stomach: 7 nTPM (protected, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); lymph node: 6 nTPM (protected, limit 2); spleen: 5.8 nTPM (manageable, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); lung: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); salivary gland: 5.4 nTPM (protected, limit 2); rectum: 5.2 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000090612,ZNF268,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.480612,-0.547982,-0.564074
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 95%, Missing); adrenal gland: 59.3548% (minimum 99%, Missing); amygdala: 76.0331% (minimum 99%, Missing); basal ganglia: 74.7967% (minimum 99%, Missing); bone marrow: 72.4409% (minimum 99%, Missing); cerebellum: 72.4409% (minimum 99%, Missing); cerebral cortex: 58.2278% (minimum 99%, Missing); choroid plexus: 65.2482% (minimum 99%, Missing); colon: 63.0137% (minimum 97%, Missing); duodenum: 68.1481% (minimum 99%, Missing); esophagus: 59.7403% (minimum 97%, Missing); heart muscle: 68.6567% (minimum 99%, Missing); hippocampal formation: 78.6325% (minimum 99%, Missing); hypothalamus: 76.6667% (minimum 99%, Missing); kidney: 50.5495% (minimum 99%, Missing); liver: 42.5926% (minimum 99%, Missing); lung: 63.0137% (minimum 99%, Missing); lymph node: 60.5263% (minimum 95%, Approved); midbrain: 79.3103% (minimum 99%, Missing); pancreas: 64.3357% (minimum 99%, Missing); parathyroid gland: 42.2018% (minimum 97%, Missing); pituitary gland: 70.7692% (minimum 99%, Missing); rectum: 63.8889% (minimum 97%, Missing); retina: 44.2308% (minimum 99%, Missing); salivary gland: 63.0137% (minimum 97%, Missing); skeletal muscle: 80.0000% (minimum 99%, Missing); skin: 64.7887% (minimum 95%, Missing); small intestine: 64.7887% (minimum 99%, Missing); smooth muscle: 62.1622% (minimum 99%, Missing); spinal cord: 78.6325% (minimum 99%, Missing); spleen: 61.3333% (minimum 95%, Missing); stomach: 56.7901% (minimum 97%, Missing); thymus: 56.4417% (minimum 95%, Missing); thyroid gland: 46.9388% (minimum 95%, Missing); tongue: 66.1871% (minimum 97%, Missing); urinary bladder: 60.1307% (minimum 97%, Missing)",0,3,partial,12.4,12.6,10.4,"parathyroid gland: 12.6 nTPM (protected, limit 2); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); kidney: 9 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); stomach: 7 nTPM (protected, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); lymph node: 6 nTPM (protected, limit 4); spleen: 5.8 nTPM (manageable, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); lung: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); salivary gland: 5.4 nTPM (protected, limit 2); rectum: 5.2 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000090612,ZNF268,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.480612,-0.547982,-0.564074
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,11.1,5.3,12.3,"thymus: 12.3 nTPM (manageable, limit 5); bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000090889,KIF4A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.6154% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 16.5414% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.6154% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 37.9310% (minimum 97%, Baseline (adaptation disabled)); duodenum: 42.3077% (minimum 99%, Baseline (adaptation disabled)); esophagus: 38.5965% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.4815% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 81.4815% (minimum 99%, Baseline (adaptation disabled)); lung: 81.4815% (minimum 99%, Baseline (adaptation disabled)); lymph node: 29.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.6522% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 81.4815% (minimum 99%, Baseline (adaptation disabled)); rectum: 33.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 78.5714% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 81.4815% (minimum 97%, Baseline (adaptation disabled)); skin: 51.1628% (minimum 95%, Baseline (adaptation disabled)); small intestine: 40.7407% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.7059% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.8889% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.4103% (minimum 97%, Baseline (adaptation disabled)); thymus: 15.1724% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.6667% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 70.9677% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,11.1,5.3,12.3,"thymus: 12.3 nTPM (manageable, limit 5); bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000090889,KIF4A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.798276,-0.676667,-0.824586
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.0000% (minimum 95%, Missing); adrenal gland: 91.6667% (minimum 99%, Missing); amygdala: 88.0000% (minimum 99%, Missing); basal ganglia: 84.6154% (minimum 99%, Missing); bone marrow: 16.5414% (minimum 99%, Missing); cerebral cortex: 84.6154% (minimum 99%, Missing); choroid plexus: 88.0000% (minimum 99%, Missing); colon: 37.9310% (minimum 97%, Missing); duodenum: 42.3077% (minimum 99%, Missing); esophagus: 38.5965% (minimum 97%, Missing); heart muscle: 91.6667% (minimum 99%, Missing); hippocampal formation: 88.0000% (minimum 99%, Missing); hypothalamus: 81.4815% (minimum 99%, Missing); kidney: 91.6667% (minimum 99%, Missing); liver: 81.4815% (minimum 99%, Missing); lung: 81.4815% (minimum 99%, Missing); lymph node: 29.3333% (minimum 97%, Missing); midbrain: 91.6667% (minimum 99%, Missing); pancreas: 95.6522% (minimum 99%, Missing); pituitary gland: 81.4815% (minimum 99%, Missing); rectum: 33.3333% (minimum 97%, Missing); retina: 78.5714% (minimum 99%, Missing); salivary gland: 81.4815% (minimum 97%, Missing); skin: 51.1628% (minimum 95%, Missing); small intestine: 40.7407% (minimum 99%, Missing); smooth muscle: 64.7059% (minimum 98%, Approved); spinal cord: 91.6667% (minimum 99%, Missing); spleen: 48.8889% (minimum 95%, Missing); stomach: 56.4103% (minimum 97%, Missing); thymus: 15.1724% (minimum 95%, Missing); thyroid gland: 91.6667% (minimum 95%, Missing); urinary bladder: 70.9677% (minimum 97%, Missing)",0,3,partial,11.1,5.3,12.3,"thymus: 12.3 nTPM (manageable, limit 5); bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000090889,KIF4A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.798276,-0.676667,-0.824586
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,10.1,7.2,6,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thymus: 6 nTPM (manageable, limit 5); esophagus: 3.9 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000091651,ORC6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.9394% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.5789% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.4872% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 47.9381% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.3009% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.4000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.8947% (minimum 99%, Baseline (adaptation disabled)); colon: 85.3211% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.1111% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.4545% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.9159% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.1724% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.7838% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.8763% (minimum 99%, Baseline (adaptation disabled)); liver: 91.1765% (minimum 99%, Baseline (adaptation disabled)); lung: 93.9394% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.3636% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.9159% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.8750% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.8980% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.7838% (minimum 97%, Baseline (adaptation disabled)); retina: 97.8947% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.9362% (minimum 99%, Baseline (adaptation disabled)); skin: 89.4231% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.9159% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.1765% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.1765% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.1724% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.0792% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.7843% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 89.4231% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,10.1,7.2,6,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thymus: 6 nTPM (manageable, limit 5); esophagus: 3.9 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000091651,ORC6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.342157,-0.406364,-0.510619
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.9394% (minimum 95%, Enhanced); amygdala: 81.5789% (minimum 99%, Missing); basal ganglia: 79.4872% (minimum 99%, Missing); bone marrow: 47.9381% (minimum 99%, Missing); cerebellum: 82.3009% (minimum 99%, Missing); cerebral cortex: 74.4000% (minimum 99%, Missing); choroid plexus: 97.8947% (minimum 99%, Missing); colon: 85.3211% (minimum 97%, Missing); duodenum: 86.1111% (minimum 99%, Missing); esophagus: 70.4545% (minimum 97%, Missing); heart muscle: 86.9159% (minimum 99%, Missing); hippocampal formation: 80.1724% (minimum 99%, Missing); hypothalamus: 83.7838% (minimum 99%, Missing); kidney: 95.8763% (minimum 99%, Missing); liver: 91.1765% (minimum 99%, Missing); lung: 93.9394% (minimum 99%, Missing); lymph node: 56.3636% (minimum 97%, Missing); midbrain: 86.9159% (minimum 99%, Missing); pancreas: 96.8750% (minimum 99%, Missing); parathyroid gland: 93.0000% (minimum 97%, Missing); pituitary gland: 94.8980% (minimum 99%, Missing); rectum: 83.7838% (minimum 97%, Missing); retina: 97.8947% (minimum 99%, Missing); salivary gland: 93.0000% (minimum 97%, Missing); skin: 89.4231% (minimum 95%, Missing); small intestine: 86.9159% (minimum 99%, Missing); smooth muscle: 91.1765% (minimum 95%, Enhanced); spinal cord: 91.1765% (minimum 99%, Missing); stomach: 92.0792% (minimum 97%, Missing); thymus: 60.7843% (minimum 95%, Missing)",0,8,partial,10.1,7.2,6,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thymus: 6 nTPM (manageable, limit 5); esophagus: 3.9 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000091651,ORC6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.342157,-0.406364,-0.510619
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,179.2,0.5,1.4,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000092200,RPGRIP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 98.6301% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9691% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6301% (minimum 99%, Baseline (adaptation disabled)); retina: 24.3243% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,179.2,0.5,1.4,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000092200,RPGRIP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0262712,0.0213941,-0.746757
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 24.3243% (minimum 99%, Missing)",0,2,partial,179.2,0.5,1.4,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000092200,RPGRIP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0482669,0.0265398,-0.746757
True,compatible,,True,True,False,,0,6,partial,0.2,0.3,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000092345,DAZL,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,6,partial,0.2,0.3,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000092345,DAZL,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.048708,0.026134,0.00741935
True,compatible,,True,True,True,,0,6,partial,0.2,0.3,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000092345,DAZL,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.026134,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.1,4.8,7.7,"bone marrow: 11.1 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); retina: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000092853,CLSPN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.8033% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.5517% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.2456% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2456% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 33.5329% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.8033% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.2456% (minimum 99%, Baseline (adaptation disabled)); colon: 81.1594% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.8485% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.1538% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.2456% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.5517% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.2456% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2456% (minimum 99%, Baseline (adaptation disabled)); liver: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.8462% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.2456% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.5517% (minimum 97%, Baseline (adaptation disabled)); rectum: 73.6842% (minimum 97%, Baseline (adaptation disabled)); retina: 45.9016% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.5517% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.8033% (minimum 99%, Baseline (adaptation disabled)); skin: 83.5821% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.8485% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.1538% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2456% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.3529% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.5000% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.1053% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 90.3226% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.1,4.8,7.7,"bone marrow: 11.1 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); retina: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000092853,CLSPN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.528947,-0.431538,-0.654671
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.8033% (minimum 95%, Missing); adrenal gland: 96.5517% (minimum 99%, Missing); amygdala: 98.2456% (minimum 99%, Missing); basal ganglia: 98.2456% (minimum 99%, Missing); bone marrow: 33.5329% (minimum 99%, Missing); cerebral cortex: 91.8033% (minimum 99%, Missing); choroid plexus: 98.2456% (minimum 99%, Missing); colon: 81.1594% (minimum 97%, Missing); duodenum: 84.8485% (minimum 99%, Missing); esophagus: 86.1538% (minimum 97%, Missing); heart muscle: 98.2456% (minimum 99%, Missing); hippocampal formation: 96.5517% (minimum 99%, Missing); hypothalamus: 98.2456% (minimum 99%, Missing); kidney: 98.2456% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); lung: 93.3333% (minimum 99%, Missing); lymph node: 53.8462% (minimum 97%, Missing); pancreas: 98.2456% (minimum 99%, Missing); parathyroid gland: 96.5517% (minimum 97%, Missing); rectum: 73.6842% (minimum 97%, Missing); retina: 45.9016% (minimum 99%, Missing); salivary gland: 96.5517% (minimum 97%, Missing); skeletal muscle: 91.8033% (minimum 99%, Missing); skin: 83.5821% (minimum 95%, Missing); small intestine: 84.8485% (minimum 99%, Missing); smooth muscle: 86.1538% (minimum 99%, Missing); spinal cord: 98.2456% (minimum 99%, Missing); spleen: 82.3529% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thymus: 42.1053% (minimum 95%, Missing); urinary bladder: 90.3226% (minimum 97%, Missing)",0,80,unavailable,11.1,4.8,7.7,"bone marrow: 11.1 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); retina: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000092853,CLSPN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.528947,-0.431538,-0.654671
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,25.1,11.1,19.8,"bone marrow: 25.1 nTPM (vital, limit 1); thymus: 19.8 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibrohistiocytic cells; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000093009,CDC45,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.8448% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 47.4895% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6957% (minimum 99%, Baseline (adaptation disabled)); colon: 83.4559% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.9732% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.6547% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.6957% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6957% (minimum 99%, Baseline (adaptation disabled)); liver: 95.3782% (minimum 99%, Baseline (adaptation disabled)); lung: 96.1864% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.1598% (minimum 97%, Baseline (adaptation disabled)); rectum: 79.6491% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.1864% (minimum 97%, Baseline (adaptation disabled)); skin: 87.6448% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.3268% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.0328% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.0196% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.0794% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.4118% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.2764% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,25.1,11.1,19.8,"bone marrow: 25.1 nTPM (vital, limit 1); thymus: 19.8 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); esophagus: 5.1 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibrohistiocytic cells; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000093009,CDC45,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.415882,-0.298402,-0.515105
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 47.4895% (minimum 99%, Missing); cerebral cortex: 98.6957% (minimum 99%, Missing); colon: 83.4559% (minimum 97%, Missing); duodenum: 86.9732% (minimum 95%, Enhanced); kidney: 98.6957% (minimum 99%, Missing); lung: 96.1864% (minimum 99%, Missing); lymph node: 67.1598% (minimum 97%, Missing); rectum: 79.6491% (minimum 80%, Enhanced); skin: 87.6448% (minimum 95%, Missing); small intestine: 88.3268% (minimum 95%, Enhanced); smooth muscle: 93.0328% (minimum 95%, Enhanced); stomach: 90.0794% (minimum 97%, Missing); thymus: 53.4118% (minimum 95%, Missing); urinary bladder: 92.2764% (minimum 97%, Missing)",0,7,partial,25.1,11.1,19.8,"bone marrow: 25.1 nTPM (vital, limit 1); thymus: 19.8 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibrohistiocytic cells; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000093009,CDC45,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.415882,-0.298402,-0.515105
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,26.9,16,16.2,"bone marrow: 26.9 nTPM (vital, limit 1); thymus: 16.2 nTPM (manageable, limit 5); lymph node: 16 nTPM (protected, limit 2); rectum: 8.4 nTPM (protected, limit 2); colon: 8.1 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000094804,CDC6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.3529% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.4828% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.2308% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 26.7030% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.7257% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 54.7486% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.3099% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.0523% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.2308% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.1456% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.1456% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.1456% (minimum 99%, Baseline (adaptation disabled)); liver: 77.1654% (minimum 99%, Baseline (adaptation disabled)); lung: 88.2883% (minimum 99%, Baseline (adaptation disabled)); lymph node: 37.9845% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.0297% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.4828% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.4528% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.1456% (minimum 99%, Baseline (adaptation disabled)); rectum: 53.8462% (minimum 97%, Baseline (adaptation disabled)); retina: 95.1456% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.2883% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.0297% (minimum 99%, Baseline (adaptation disabled)); skin: 78.4000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.1227% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.1343% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.0297% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.1343% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.6842% (minimum 97%, Baseline (adaptation disabled)); thymus: 37.6923% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.2174% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.1456% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 70.0000% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,26.9,16,16.2,"bone marrow: 26.9 nTPM (vital, limit 1); thymus: 16.2 nTPM (manageable, limit 5); lymph node: 16 nTPM (protected, limit 2); rectum: 8.4 nTPM (protected, limit 2); colon: 8.1 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000094804,CDC6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.573077,-0.590155,-0.72297
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.3529% (minimum 90%, Approved); adrenal gland: 84.4828% (minimum 99%, Missing); amygdala: 94.2308% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); bone marrow: 26.7030% (minimum 99%, Missing); cerebellum: 93.3333% (minimum 99%, Missing); cerebral cortex: 86.7257% (minimum 99%, Missing); choroid plexus: 93.3333% (minimum 99%, Missing); colon: 54.7486% (minimum 97%, Missing); duodenum: 57.3099% (minimum 99%, Missing); esophagus: 64.0523% (minimum 97%, Missing); heart muscle: 94.2308% (minimum 99%, Missing); hippocampal formation: 95.1456% (minimum 99%, Missing); hypothalamus: 95.1456% (minimum 99%, Missing); kidney: 95.1456% (minimum 99%, Missing); liver: 77.1654% (minimum 99%, Missing); lung: 88.2883% (minimum 99%, Missing); lymph node: 37.9845% (minimum 97%, Missing); midbrain: 97.0297% (minimum 99%, Missing); pancreas: 84.4828% (minimum 99%, Missing); parathyroid gland: 92.4528% (minimum 95%, Approved); pituitary gland: 95.1456% (minimum 99%, Missing); rectum: 53.8462% (minimum 97%, Missing); retina: 95.1456% (minimum 99%, Missing); salivary gland: 88.2883% (minimum 97%, Missing); skeletal muscle: 97.0297% (minimum 99%, Missing); skin: 78.4000% (minimum 95%, Missing); small intestine: 60.1227% (minimum 99%, Missing); smooth muscle: 73.1343% (minimum 99%, Missing); spinal cord: 97.0297% (minimum 99%, Missing); spleen: 73.1343% (minimum 95%, Missing); stomach: 73.6842% (minimum 97%, Missing); thymus: 37.6923% (minimum 95%, Missing); thyroid gland: 85.2174% (minimum 95%, Missing); tongue: 95.1456% (minimum 97%, Missing); urinary bladder: 70.0000% (minimum 97%, Missing)",0,1,partial,26.9,16,16.2,"bone marrow: 26.9 nTPM (vital, limit 1); thymus: 16.2 nTPM (manageable, limit 5); lymph node: 16 nTPM (protected, limit 2); rectum: 8.4 nTPM (protected, limit 2); colon: 8.1 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000094804,CDC6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.573077,-0.590155,-0.72297
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,10,partial,115.3,24.8,30.2,"choroid plexus: 115.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 2); thyroid gland: 23.2 nTPM (manageable, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 6); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 2); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 6); rectum: 10.5 nTPM (protected, limit 2); smooth muscle: 10.4 nTPM (vital, limit 6); spleen: 10.4 nTPM (manageable, limit 5); colon: 10.2 nTPM (protected, limit 2); stomach: 10 nTPM (protected, limit 2); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); small intestine: 8.5 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 6); tongue: 7.4 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Low (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / sebaceous glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000094916,CBX5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 76.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.4909% (minimum 99%, Baseline (adaptation disabled)); amygdala: 55.8824% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 57.7103% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.3750% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.2439% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.8142% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 17.6429% (minimum 99%, Baseline (adaptation disabled)); colon: 70.7736% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.1875% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.2938% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 55.1339% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 59.3750% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.4632% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.8063% (minimum 99%, Baseline (adaptation disabled)); liver: 76.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 72.6471% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.3086% (minimum 97%, Baseline (adaptation disabled)); midbrain: 57.8454% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.8023% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.8990% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.2642% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.1705% (minimum 97%, Baseline (adaptation disabled)); retina: 52.6652% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.8485% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 59.5181% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.3976% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.3704% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 54.8889% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.3704% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.1816% (minimum 97%, Baseline (adaptation disabled)); thymus: 44.9909% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 51.5658% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.9470% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.1646% (minimum 97%, Baseline (adaptation disabled))",0,10,partial,115.3,24.8,30.2,"choroid plexus: 115.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 2); thyroid gland: 23.2 nTPM (manageable, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 2); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 2); smooth muscle: 10.4 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); colon: 10.2 nTPM (protected, limit 2); stomach: 10 nTPM (protected, limit 2); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); small intestine: 8.5 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Low (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / sebaceous glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000094916,CBX5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.500091,-0.47101,-0.813571
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 76.0000% (minimum 95%, Missing); adrenal gland: 64.4909% (minimum 99%, Missing); amygdala: 55.8824% (minimum 99%, Missing); basal ganglia: 57.7103% (minimum 99%, Missing); bone marrow: 59.3750% (minimum 99%, Missing); cerebellum: 60.2439% (minimum 99%, Missing); cerebral cortex: 48.8142% (minimum 99%, Missing); choroid plexus: 17.6429% (minimum 99%, Missing); colon: 70.7736% (minimum 97%, Missing); duodenum: 77.1875% (minimum 99%, Missing); esophagus: 73.2938% (minimum 97%, Missing); heart muscle: 55.1339% (minimum 95%, Enhanced); hippocampal formation: 59.3750% (minimum 99%, Missing); hypothalamus: 53.4632% (minimum 99%, Missing); kidney: 59.8063% (minimum 99%, Missing); liver: 76.0000% (minimum 95%, Enhanced); lung: 72.6471% (minimum 99%, Missing); lymph node: 57.3086% (minimum 97%, Missing); midbrain: 57.8454% (minimum 99%, Missing); pancreas: 71.8023% (minimum 99%, Missing); parathyroid gland: 49.8990% (minimum 97%, Missing); pituitary gland: 56.2642% (minimum 99%, Missing); rectum: 70.1705% (minimum 97%, Missing); retina: 52.6652% (minimum 99%, Missing); salivary gland: 74.8485% (minimum 97%, Missing); skeletal muscle: 65.0000% (minimum 95%, Enhanced); skin: 59.5181% (minimum 95%, Missing); small intestine: 74.3976% (minimum 99%, Missing); smooth muscle: 70.3704% (minimum 95%, Enhanced); spinal cord: 54.8889% (minimum 99%, Missing); spleen: 70.3704% (minimum 95%, Missing); stomach: 71.1816% (minimum 97%, Missing); thymus: 44.9909% (minimum 95%, Missing); thyroid gland: 51.5658% (minimum 95%, Missing); tongue: 76.9470% (minimum 97%, Missing); urinary bladder: 78.1646% (minimum 97%, Missing)",0,10,partial,115.3,24.8,30.2,"choroid plexus: 115.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 2); thyroid gland: 23.2 nTPM (manageable, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 6); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 2); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 6); rectum: 10.5 nTPM (protected, limit 2); smooth muscle: 10.4 nTPM (vital, limit 6); spleen: 10.4 nTPM (manageable, limit 5); colon: 10.2 nTPM (protected, limit 2); stomach: 10 nTPM (protected, limit 2); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); small intestine: 8.5 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 6); tongue: 7.4 nTPM (protected, limit 2); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Low (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / sebaceous glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000094916,CBX5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.500091,-0.47101,-0.813571
True,compatible,,True,True,False,,0,1,partial,1.6,0.4,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000095627,TDRD1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.0645% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.7013% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.8153% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.4762% (minimum 99%, Baseline (adaptation disabled)); liver: 98.7013% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.8153% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.7013% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.7013% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,1.6,0.4,0.5,"kidney: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000095627,TDRD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023,0.0181529,0.00435897,-0.0852381
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 90.4762% (minimum 95%, Enhanced)",0,1,partial,1.6,0.4,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000095627,TDRD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023,0.037013,0.00435897,-0.0452381
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,15,0.3,0.7,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),61,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000095777,MYO3A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 98.0392% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.0392% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.5294% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0392% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.0392% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.3396% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 98.0392% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.3396% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0392% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.7193% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.5926% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.3396% (minimum 97%, Baseline (adaptation disabled)); retina: 25.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 87.7193% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.0392% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.1538% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,15,0.3,0.7,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),61,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000095777,MYO3A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.072807,-0.0266038,-0.74
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 98.0392% (minimum 99%, Missing); amygdala: 98.0392% (minimum 99%, Missing); basal ganglia: 73.5294% (minimum 99%, Missing); choroid plexus: 98.0392% (minimum 99%, Missing); esophagus: 94.3396% (minimum 97%, Missing); hippocampal formation: 98.0392% (minimum 99%, Missing); hypothalamus: 90.9091% (minimum 99%, Missing); kidney: 94.3396% (minimum 99%, Missing); pancreas: 87.7193% (minimum 95%, Enhanced); pituitary gland: 92.5926% (minimum 99%, Missing); retina: 25.0000% (minimum 99%, Missing); skin: 87.7193% (minimum 95%, Missing); stomach: 96.1538% (minimum 97%, Missing)",0,3,partial,15,0.3,0.7,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),61,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000095777,MYO3A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.072807,-0.0266038,-0.74
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,18,partial,131.7,58,52.6,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 12); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (manageable, limit 30); heart muscle: 47.7 nTPM (vital, limit 1); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 6); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 2); lung: 29.1 nTPM (vital, limit 1); thymus: 28.4 nTPM (manageable, limit 5); skeletal muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 23.4 nTPM (vital, limit 6); colon: 23.3 nTPM (protected, limit 2); parathyroid gland: 22.9 nTPM (protected, limit 2); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 2); lymph node: 17 nTPM (protected, limit 12); esophagus: 16.8 nTPM (protected, limit 12); pancreas: 15.1 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); salivary gland: 13.2 nTPM (protected, limit 2); rectum: 13 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / extracellular matrix: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / extracellular matrix; skin 1 / fibrohistiocytic cells; skin 2 / extracellular matrix; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000095794,CREM,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 79.4451% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.6866% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.0430% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.6026% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.4359% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.5143% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.8005% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.4942% (minimum 99%, Baseline (adaptation disabled)); colon: 89.7176% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.9868% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.3671% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.9960% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.5280% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.1833% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.3128% (minimum 99%, Baseline (adaptation disabled)); liver: 77.8331% (minimum 99%, Baseline (adaptation disabled)); lung: 87.4785% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.2833% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.4202% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.0861% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.8762% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.8927% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.9898% (minimum 97%, Baseline (adaptation disabled)); retina: 90.3556% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.9030% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.8565% (minimum 99%, Baseline (adaptation disabled)); small intestine: 93.0861% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.6780% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.2768% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.4413% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.1659% (minimum 97%, Baseline (adaptation disabled)); thymus: 87.7428% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.4762% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.3657% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.8033% (minimum 97%, Baseline (adaptation disabled))",0,18,partial,131.7,58,52.6,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 2); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (manageable, limit 5); heart muscle: 47.7 nTPM (vital, limit 1); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 1); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 2); lung: 29.1 nTPM (vital, limit 1); thymus: 28.4 nTPM (manageable, limit 5); skeletal muscle: 28.1 nTPM (vital, limit 1); spleen: 24 nTPM (manageable, limit 5); smooth muscle: 23.4 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 2); parathyroid gland: 22.9 nTPM (protected, limit 2); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); thyroid gland: 21.4 nTPM (manageable, limit 5); stomach: 19.7 nTPM (protected, limit 2); lymph node: 17 nTPM (protected, limit 2); esophagus: 16.8 nTPM (protected, limit 2); small intestine: 15.1 nTPM (vital, limit 1); pancreas: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); salivary gland: 13.2 nTPM (protected, limit 2); rectum: 13 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / extracellular matrix: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / extracellular matrix; skin 1 / fibrohistiocytic cells; skin 2 / extracellular matrix; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000095794,CREM,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.155549,-0.191967,-0.383134
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.6866% (minimum 99%, Missing); amygdala: 84.0430% (minimum 99%, Missing); basal ganglia: 84.6026% (minimum 99%, Missing); bone marrow: 90.4359% (minimum 99%, Missing); cerebellum: 93.5143% (minimum 99%, Missing); cerebral cortex: 83.8005% (minimum 95%, Enhanced); choroid plexus: 78.4942% (minimum 99%, Missing); colon: 89.7176% (minimum 97%, Missing); duodenum: 95.9868% (minimum 99%, Missing); heart muscle: 80.9960% (minimum 99%, Missing); hippocampal formation: 85.5280% (minimum 99%, Missing); hypothalamus: 83.1833% (minimum 99%, Missing); kidney: 78.3128% (minimum 99%, Missing); liver: 77.8331% (minimum 99%, Missing); lung: 87.4785% (minimum 99%, Missing); midbrain: 85.4202% (minimum 99%, Missing); pancreas: 93.0861% (minimum 99%, Missing); parathyroid gland: 89.8762% (minimum 97%, Missing); pituitary gland: 77.8927% (minimum 99%, Missing); rectum: 93.9898% (minimum 97%, Missing); retina: 90.3556% (minimum 99%, Missing); salivary gland: 93.9030% (minimum 97%, Missing); skeletal muscle: 87.8565% (minimum 99%, Missing); small intestine: 93.0861% (minimum 99%, Missing); smooth muscle: 89.6780% (minimum 95%, Enhanced); spinal cord: 85.2768% (minimum 99%, Missing); stomach: 91.1659% (minimum 97%, Missing); thymus: 87.7428% (minimum 95%, Missing); tongue: 87.3657% (minimum 97%, Missing); urinary bladder: 77.8033% (minimum 80%, Enhanced)",0,18,partial,131.7,58,52.6,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 12); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (manageable, limit 30); heart muscle: 47.7 nTPM (vital, limit 1); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 6); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 2); lung: 29.1 nTPM (vital, limit 1); thymus: 28.4 nTPM (manageable, limit 5); skeletal muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 23.4 nTPM (vital, limit 6); colon: 23.3 nTPM (protected, limit 2); parathyroid gland: 22.9 nTPM (protected, limit 2); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 2); lymph node: 17 nTPM (protected, limit 12); esophagus: 16.8 nTPM (protected, limit 12); pancreas: 15.1 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); salivary gland: 13.2 nTPM (protected, limit 2); rectum: 13 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / extracellular matrix: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / extracellular matrix; skin 1 / fibrohistiocytic cells; skin 2 / extracellular matrix; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000095794,CREM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0725723,-0.0963429,-0.383134
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.4,0.3,0.9,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000099338,CATSPERG,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 92.7052% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.7055% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.7055% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.9119% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0707% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.4,0.3,0.9,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000099338,CATSPERG,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0213376,0.0202597,-0.0629483
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 92.7052% (minimum 99%, Missing); choroid plexus: 98.7055% (minimum 99%, Missing); duodenum: 98.7055% (minimum 99%, Missing); midbrain: 95.9119% (minimum 99%, Missing); spinal cord: 98.0707% (minimum 99%, Missing)",0,80,unavailable,2.4,0.3,0.9,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000099338,CATSPERG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0213376,0.0202597,-0.0629483
True,compatible,,True,True,False,,0,3,partial,0.1,0,0,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000099399,MAGEB2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0.1,0,0,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000099399,MAGEB2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.00646643
True,compatible,,True,True,True,,0,3,partial,0.1,0,0,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000099399,MAGEB2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,ENSG00000099721,AMELY,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"pancreas: 50.0000% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 25.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,ENSG00000099721,AMELY,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.7,0.03,-0.49
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"pancreas: 50.0000% (minimum 99%, Missing); thyroid gland: 25.0000% (minimum 95%, Missing)",0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,ENSG00000099721,AMELY,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.7,0.03,-0.49
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,17.8,3.8,4.4,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 6); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 6); cerebellum: 6.1 nTPM (vital, limit 6); kidney: 4.1 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000099840,IZUMO4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.0321% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.5703% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6038% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.5270% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.1583% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.9833% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.3559% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8073% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.7655% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0874% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.7536% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.3543% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,17.8,3.8,4.4,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); heart muscle: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000099840,IZUMO4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0398897,0.0212563,-0.029679
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.0321% (minimum 99%, Missing); basal ganglia: 96.5703% (minimum 99%, Missing); choroid plexus: 97.1583% (minimum 99%, Missing); hippocampal formation: 96.9833% (minimum 99%, Missing); hypothalamus: 97.3559% (minimum 99%, Missing); midbrain: 96.7655% (minimum 99%, Missing); pituitary gland: 97.7536% (minimum 99%, Missing); spinal cord: 96.3543% (minimum 99%, Missing)",0,2,partial,17.8,3.8,4.4,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 6); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 6); cerebellum: 6.1 nTPM (vital, limit 6); kidney: 4.1 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000099840,IZUMO4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0460694,0.0272222,-0.029679
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,9.1,5.1,3.7,"smooth muscle: 9.1 nTPM (vital, limit 2); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 2); small intestine: 5.9 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); adrenal gland: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000099953,MMP11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8580% (minimum 99%, Baseline (adaptation disabled)); duodenum: 95.4514% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.1890% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2270% (minimum 99%, Baseline (adaptation disabled)); lung: 98.9993% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.4485% (minimum 97%, Baseline (adaptation disabled)); small intestine: 95.9141% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.8347% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,9.1,5.1,3.7,"smooth muscle: 9.1 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); lymph node: 3.9 nTPM (protected, limit 2); colon: 3.8 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000099953,MMP11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,0.0239803,-0.00551532,-0.0516531
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8580% (minimum 99%, Missing); duodenum: 95.4514% (minimum 98%, Approved); heart muscle: 95.1890% (minimum 99%, Missing); kidney: 98.2270% (minimum 99%, Missing); salivary gland: 96.4485% (minimum 97%, Missing); small intestine: 95.9141% (minimum 99%, Missing); smooth muscle: 93.8347% (minimum 98%, Approved)",0,0,routine_complete,9.1,5.1,3.7,"smooth muscle: 9.1 nTPM (vital, limit 2); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 2); small intestine: 5.9 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); adrenal gland: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000099953,MMP11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,0.0274171,-0.00551532,-0.0416531
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,25.3,6.2,14.2,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); thymus: 14.2 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 2); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); midbrain: 3 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100027,YPEL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.1649% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.7059% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.8759% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.2889% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.0628% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.1714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 95.9288% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.0399% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 91.5049% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.6250% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.4020% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.0399% (minimum 99%, Baseline (adaptation disabled)); liver: 96.9152% (minimum 99%, Baseline (adaptation disabled)); lung: 93.3168% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.9716% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.1735% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.2020% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.9288% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.7908% (minimum 99%, Baseline (adaptation disabled)); retina: 95.4430% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.2230% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.9152% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.9152% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.9622% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.1914% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.8069% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.1518% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.4020% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,25.3,6.2,14.2,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); thymus: 14.2 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 2); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); midbrain: 3 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100027,YPEL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.108482,-0.0459804,-0.241241
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.1649% (minimum 99%, Missing); amygdala: 88.7059% (minimum 99%, Missing); basal ganglia: 74.8759% (minimum 99%, Missing); bone marrow: 92.2889% (minimum 99%, Missing); cerebellum: 91.0628% (minimum 99%, Missing); cerebral cortex: 86.1714% (minimum 99%, Missing); choroid plexus: 86.6667% (minimum 99%, Missing); colon: 95.9288% (minimum 97%, Missing); duodenum: 97.0399% (minimum 99%, Missing); heart muscle: 91.5049% (minimum 99%, Missing); hippocampal formation: 90.6250% (minimum 99%, Missing); hypothalamus: 92.4020% (minimum 99%, Missing); kidney: 97.0399% (minimum 99%, Missing); liver: 96.9152% (minimum 99%, Missing); lung: 93.3168% (minimum 99%, Missing); lymph node: 92.9716% (minimum 97%, Missing); midbrain: 96.1735% (minimum 99%, Missing); pancreas: 95.2020% (minimum 99%, Missing); parathyroid gland: 95.9288% (minimum 97%, Missing); pituitary gland: 96.7908% (minimum 99%, Missing); retina: 95.4430% (minimum 99%, Missing); salivary gland: 96.6667% (minimum 97%, Missing); skeletal muscle: 83.2230% (minimum 99%, Missing); small intestine: 96.9152% (minimum 99%, Missing); smooth muscle: 96.9152% (minimum 99%, Missing); spinal cord: 94.9622% (minimum 99%, Missing); spleen: 90.1914% (minimum 95%, Missing); stomach: 95.8069% (minimum 97%, Missing); thymus: 84.1518% (minimum 95%, Missing); tongue: 92.4020% (minimum 97%, Missing)",0,2,partial,25.3,6.2,14.2,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); thymus: 14.2 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 2); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); midbrain: 3 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100027,YPEL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.108482,-0.0459804,-0.241241
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.2,2,4.8,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000100121,GGTLC2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.6350% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.3673% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.3372% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.5709% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5709% (minimum 99%, Baseline (adaptation disabled)); lung: 96.4000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.3372% (minimum 97%, Baseline (adaptation disabled)); pancreas: 96.4000% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7705% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.3673% (minimum 99%, Baseline (adaptation disabled)); skin: 91.2879% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.6349% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3910% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2.2,2,4.8,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000100121,GGTLC2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021;Loriot 2025,-0.11609,-0.0466284,-0.0736502
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.6350% (minimum 99%, Missing); cerebral cortex: 98.3673% (minimum 99%, Missing); choroid plexus: 92.3372% (minimum 99%, Missing); duodenum: 97.5709% (minimum 99%, Missing); kidney: 97.5709% (minimum 99%, Missing); lung: 96.4000% (minimum 99%, Missing); lymph node: 92.3372% (minimum 97%, Missing); pancreas: 96.4000% (minimum 99%, Missing); retina: 98.7705% (minimum 99%, Missing); skeletal muscle: 98.3673% (minimum 99%, Missing); skin: 91.2879% (minimum 95%, Missing); small intestine: 95.6349% (minimum 99%, Missing); spleen: 83.3910% (minimum 95%, Missing)",0,80,unavailable,2.2,2,4.8,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000100121,GGTLC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021;Loriot 2025,-0.11609,-0.0466284,-0.0736502
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,2.2,2.6,3.2,"heart muscle: 2.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000100206,DMC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.2623% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.2906% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.0413% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.0413% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.8209% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.0413% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.2623% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.6387% (minimum 99%, Baseline (adaptation disabled)); colon: 93.4959% (minimum 97%, Baseline (adaptation disabled)); esophagus: 94.2623% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.9416% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.6387% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.6387% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.6387% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2906% (minimum 99%, Baseline (adaptation disabled)); lung: 96.6387% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.5603% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.6387% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.6387% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.4576% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 94.2623% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 90.5512% (minimum 99%, Baseline (adaptation disabled)); skin: 89.1473% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.0413% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.2623% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.8333% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.0413% (minimum 97%, Baseline (adaptation disabled)); thymus: 78.2313% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.8333% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.8333% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,2.2,2.6,3.2,"lymph node: 2.6 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000100206,DMC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.167687,-0.154397,-0.150584
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.0413% (minimum 99%, Missing); basal ganglia: 95.0413% (minimum 99%, Missing); bone marrow: 85.8209% (minimum 95%, Enhanced); cerebral cortex: 94.2623% (minimum 95%, Enhanced); choroid plexus: 96.6387% (minimum 99%, Missing); heart muscle: 83.9416% (minimum 99%, Missing); hippocampal formation: 96.6387% (minimum 99%, Missing); hypothalamus: 96.6387% (minimum 99%, Missing); midbrain: 96.6387% (minimum 99%, Missing); pituitary gland: 97.4576% (minimum 99%, Missing); retina: 94.2623% (minimum 99%, Missing); skeletal muscle: 90.5512% (minimum 95%, Enhanced); smooth muscle: 94.2623% (minimum 95%, Enhanced); spinal cord: 95.8333% (minimum 99%, Missing); thymus: 78.2313% (minimum 95%, Missing); tongue: 95.8333% (minimum 97%, Missing)",0,2,partial,2.2,2.6,3.2,"heart muscle: 2.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000100206,DMC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.167687,-0.0116667,-0.150584
True,compatible,,True,True,False,,0,3,partial,1.9,0.6,2.9,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000100312,ACR,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.9437% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.9437% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7958% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.9,0.6,2.9,"lung: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000100312,ACR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0167431,0.0229329,-0.0120418
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.9437% (minimum 99%, Missing)",0,3,partial,1.9,0.6,2.9,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000100312,ACR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00056338
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,16.2,8.2,7.1,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 2); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thyroid gland: 7.1 nTPM (manageable, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); salivary gland: 4.9 nTPM (protected, limit 2); tongue: 4.8 nTPM (protected, limit 2); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); small intestine: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); esophagus: 3.9 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100478,AP4S1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.5957% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.7895% (minimum 99%, Baseline (adaptation disabled)); amygdala: 55.8140% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 53.9326% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.2308% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.2500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 47.0588% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.2370% (minimum 99%, Baseline (adaptation disabled)); colon: 63.7168% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.7586% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.6885% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.2897% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.5985% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.0645% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 75.3927% (minimum 99%, Baseline (adaptation disabled)); lung: 75.7895% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.7168% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.9245% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.0053% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.4469% (minimum 97%, Baseline (adaptation disabled)); retina: 59.2593% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.6114% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 56.4706% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.8378% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.5652% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.4545% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.8995% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.8378% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.7895% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.9767% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 70.5882% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,16.2,8.2,7.1,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 2); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thyroid gland: 7.1 nTPM (manageable, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); salivary gland: 4.9 nTPM (protected, limit 2); tongue: 4.8 nTPM (protected, limit 2); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); small intestine: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); esophagus: 3.9 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100478,AP4S1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.280233,-0.332832,-0.519412
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.5957% (minimum 95%, Missing); adrenal gland: 75.7895% (minimum 99%, Missing); amygdala: 55.8140% (minimum 99%, Missing); basal ganglia: 53.9326% (minimum 99%, Missing); bone marrow: 69.2308% (minimum 99%, Missing); cerebellum: 56.2500% (minimum 99%, Missing); cerebral cortex: 47.0588% (minimum 99%, Missing); choroid plexus: 83.2370% (minimum 99%, Missing); colon: 63.7168% (minimum 97%, Missing); duodenum: 82.7586% (minimum 99%, Missing); esophagus: 78.6885% (minimum 97%, Missing); heart muscle: 67.2897% (minimum 99%, Missing); hippocampal formation: 55.5985% (minimum 99%, Missing); hypothalamus: 58.0645% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 75.3927% (minimum 99%, Missing); lung: 75.7895% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 63.7168% (minimum 99%, Missing); pancreas: 67.9245% (minimum 99%, Missing); parathyroid gland: 77.0053% (minimum 97%, Missing); pituitary gland: 64.0000% (minimum 99%, Missing); rectum: 80.4469% (minimum 97%, Missing); retina: 59.2593% (minimum 99%, Missing); salivary gland: 74.6114% (minimum 97%, Missing); skeletal muscle: 56.4706% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 77.8378% (minimum 99%, Missing); smooth muscle: 69.5652% (minimum 99%, Missing); spinal cord: 65.4545% (minimum 99%, Missing); spleen: 68.8995% (minimum 95%, Missing); stomach: 77.8378% (minimum 97%, Missing); thymus: 75.7895% (minimum 95%, Missing); thyroid gland: 66.9767% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 70.5882% (minimum 97%, Missing)",0,4,partial,16.2,8.2,7.1,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 2); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thyroid gland: 7.1 nTPM (manageable, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); salivary gland: 4.9 nTPM (protected, limit 2); tongue: 4.8 nTPM (protected, limit 2); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); small intestine: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); esophagus: 3.9 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100478,AP4S1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.280233,-0.332832,-0.519412
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,18.1,5.2,5.6,"bone marrow: 18.1 nTPM (vital, limit 1); thymus: 5.6 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100479,POLE2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.8462% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.1818% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.3488% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 18.4685% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.1111% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.1304% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.6735% (minimum 99%, Baseline (adaptation disabled)); colon: 52.5641% (minimum 97%, Baseline (adaptation disabled)); duodenum: 63.0769% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.2468% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.2340% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.1818% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.1111% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.4167% (minimum 99%, Baseline (adaptation disabled)); liver: 56.1644% (minimum 99%, Baseline (adaptation disabled)); lung: 78.8462% (minimum 99%, Baseline (adaptation disabled)); lymph node: 44.0860% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.1818% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.3585% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.2340% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 89.1304% (minimum 99%, Baseline (adaptation disabled)); rectum: 47.1264% (minimum 97%, Baseline (adaptation disabled)); retina: 53.9474% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.3922% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.4167% (minimum 99%, Baseline (adaptation disabled)); skin: 53.9474% (minimum 95%, Baseline (adaptation disabled)); small intestine: 53.2468% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.0794% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.1304% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.5455% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.0794% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.2680% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.3922% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.9259% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,18.1,5.2,5.6,"bone marrow: 18.1 nTPM (vital, limit 1); thymus: 5.6 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100479,POLE2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.52732,-0.52914,-0.805315
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.8462% (minimum 95%, Uncertain); adrenal gland: 82.0000% (minimum 99%, Uncertain); amygdala: 93.1818% (minimum 99%, Missing); basal ganglia: 95.3488% (minimum 99%, Missing); bone marrow: 18.4685% (minimum 99%, Missing); cerebellum: 91.1111% (minimum 99%, Uncertain); cerebral cortex: 89.1304% (minimum 99%, Uncertain); choroid plexus: 83.6735% (minimum 99%, Missing); colon: 52.5641% (minimum 97%, Missing); duodenum: 63.0769% (minimum 99%, Uncertain); esophagus: 53.2468% (minimum 97%, Missing); heart muscle: 87.2340% (minimum 99%, Uncertain); hippocampal formation: 93.1818% (minimum 99%, Missing); hypothalamus: 91.1111% (minimum 99%, Missing); kidney: 85.4167% (minimum 99%, Uncertain); liver: 56.1644% (minimum 99%, Uncertain); lung: 78.8462% (minimum 99%, Uncertain); lymph node: 44.0860% (minimum 97%, Missing); midbrain: 93.1818% (minimum 99%, Missing); pancreas: 77.3585% (minimum 99%, Uncertain); parathyroid gland: 87.2340% (minimum 97%, Uncertain); pituitary gland: 89.1304% (minimum 99%, Missing); rectum: 47.1264% (minimum 97%, Uncertain); retina: 53.9474% (minimum 99%, Missing); salivary gland: 80.3922% (minimum 97%, Uncertain); skeletal muscle: 85.4167% (minimum 99%, Uncertain); skin: 53.9474% (minimum 95%, Missing); small intestine: 53.2468% (minimum 99%, Uncertain); smooth muscle: 65.0794% (minimum 99%, Uncertain); spinal cord: 89.1304% (minimum 99%, Missing); spleen: 74.5455% (minimum 95%, Uncertain); stomach: 65.0794% (minimum 97%, Uncertain); thymus: 42.2680% (minimum 95%, Missing); thyroid gland: 82.0000% (minimum 95%, Uncertain); tongue: 80.3922% (minimum 97%, Missing); urinary bladder: 75.9259% (minimum 97%, Missing)",0,1,partial,18.1,5.2,5.6,"bone marrow: 18.1 nTPM (vital, limit 1); thymus: 5.6 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100479,POLE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.52732,-0.52914,-0.805315
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,55.4,61.3,24.4,"tongue: 61.3 nTPM (protected, limit 2); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 2); thyroid gland: 24.4 nTPM (manageable, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 10); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); spleen: 17.3 nTPM (manageable, limit 5); smooth muscle: 17.3 nTPM (vital, limit 1); skin: 17.1 nTPM (manageable, limit 5); colon: 16.8 nTPM (protected, limit 2); rectum: 16.7 nTPM (protected, limit 2); midbrain: 16.7 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 2); pancreas: 15.3 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 2); salivary gland: 14.1 nTPM (protected, limit 2); lymph node: 14 nTPM (protected, limit 2); cerebral cortex: 13.6 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); retina: 13.3 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000100485,SOS2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1082% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.2174% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.2174% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.7482% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 40.9091% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.8427% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.5025% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.0669% (minimum 99%, Baseline (adaptation disabled)); colon: 61.6438% (minimum 97%, Baseline (adaptation disabled)); duodenum: 56.4854% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.0841% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 56.6038% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.9810% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.7674% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.3597% (minimum 99%, Baseline (adaptation disabled)); liver: 68.0101% (minimum 99%, Baseline (adaptation disabled)); lung: 63.9810% (minimum 99%, Baseline (adaptation disabled)); lymph node: 65.8537% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.7849% (minimum 99%, Baseline (adaptation disabled)); pancreas: 63.8298% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 41.6025% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.2089% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.7849% (minimum 97%, Baseline (adaptation disabled)); retina: 66.9975% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.6934% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 32.7670% (minimum 99%, Baseline (adaptation disabled)); skin: 61.2245% (minimum 95%, Baseline (adaptation disabled)); small intestine: 53.2544% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.9481% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.3674% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.9481% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.9975% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.9371% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.5292% (minimum 95%, Baseline (adaptation disabled)); tongue: 30.5776% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.5340% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,55.4,61.3,24.4,"tongue: 61.3 nTPM (protected, limit 2); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 2); thyroid gland: 24.4 nTPM (manageable, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 5); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); spleen: 17.3 nTPM (manageable, limit 5); smooth muscle: 17.3 nTPM (vital, limit 1); skin: 17.1 nTPM (manageable, limit 5); colon: 16.8 nTPM (protected, limit 2); rectum: 16.7 nTPM (protected, limit 2); midbrain: 16.7 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 2); pancreas: 15.3 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 2); salivary gland: 14.1 nTPM (protected, limit 2); lymph node: 14 nTPM (protected, limit 2); cerebral cortex: 13.6 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); retina: 13.3 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000100485,SOS2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.424708,-0.664224,-0.66233
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1082% (minimum 90%, Approved); adrenal gland: 65.2174% (minimum 99%, Missing); amygdala: 65.2174% (minimum 99%, Missing); basal ganglia: 64.7482% (minimum 99%, Missing); bone marrow: 40.9091% (minimum 99%, Missing); cerebellum: 75.8427% (minimum 99%, Missing); cerebral cortex: 66.5025% (minimum 99%, Missing); choroid plexus: 82.0669% (minimum 99%, Missing); colon: 61.6438% (minimum 97%, Missing); duodenum: 56.4854% (minimum 99%, Missing); esophagus: 63.0841% (minimum 97%, Missing); heart muscle: 56.6038% (minimum 99%, Missing); hippocampal formation: 63.9810% (minimum 99%, Missing); hypothalamus: 69.7674% (minimum 99%, Missing); kidney: 53.3597% (minimum 99%, Missing); liver: 68.0101% (minimum 98%, Approved); lung: 63.9810% (minimum 99%, Missing); lymph node: 65.8537% (minimum 97%, Missing); midbrain: 61.7849% (minimum 99%, Missing); pancreas: 63.8298% (minimum 99%, Missing); parathyroid gland: 41.6025% (minimum 97%, Missing); pituitary gland: 75.2089% (minimum 99%, Missing); rectum: 61.7849% (minimum 97%, Missing); retina: 66.9975% (minimum 99%, Missing); salivary gland: 65.6934% (minimum 97%, Missing); skeletal muscle: 32.7670% (minimum 99%, Missing); skin: 61.2245% (minimum 95%, Missing); small intestine: 53.2544% (minimum 99%, Missing); smooth muscle: 60.9481% (minimum 99%, Missing); spinal cord: 56.3674% (minimum 99%, Missing); spleen: 60.9481% (minimum 95%, Missing); stomach: 66.9975% (minimum 97%, Missing); thymus: 62.9371% (minimum 95%, Missing); thyroid gland: 52.5292% (minimum 95%, Missing); tongue: 30.5776% (minimum 97%, Missing); urinary bladder: 65.5340% (minimum 97%, Missing)",0,6,partial,55.4,61.3,24.4,"tongue: 61.3 nTPM (protected, limit 2); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 2); thyroid gland: 24.4 nTPM (manageable, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 10); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); spleen: 17.3 nTPM (manageable, limit 5); smooth muscle: 17.3 nTPM (vital, limit 1); skin: 17.1 nTPM (manageable, limit 5); colon: 16.8 nTPM (protected, limit 2); rectum: 16.7 nTPM (protected, limit 2); midbrain: 16.7 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 2); pancreas: 15.3 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 2); salivary gland: 14.1 nTPM (protected, limit 2); lymph node: 14 nTPM (protected, limit 2); cerebral cortex: 13.6 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); retina: 13.3 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000100485,SOS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.424708,-0.664224,-0.66233
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,16.1,9.7,6.4,"retina: 16.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 6); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thymus: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 2); pituitary gland: 5.2 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 2); lung: 5.1 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); parathyroid gland: 4.3 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000100523,DDHD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.1720% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.5210% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.5196% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.9888% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.6623% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.8646% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.0298% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.4375% (minimum 99%, Baseline (adaptation disabled)); colon: 88.9881% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.2840% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.2840% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.9195% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.6940% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.0556% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.1464% (minimum 99%, Baseline (adaptation disabled)); liver: 92.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 85.4286% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.5051% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.9465% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.4373% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.4269% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.1852% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.9186% (minimum 97%, Baseline (adaptation disabled)); retina: 65.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.5697% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.8815% (minimum 99%, Baseline (adaptation disabled)); skin: 90.0602% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.9195% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.0814% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.2869% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.9881% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.3691% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.7898% (minimum 95%, Baseline (adaptation disabled)); tongue: 85.4286% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.9432% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,16.1,9.7,6.4,"retina: 16.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thymus: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); spleen: 6 nTPM (manageable, limit 5); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 2); pituitary gland: 5.2 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 2); lung: 5.1 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); smooth muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); parathyroid gland: 4.3 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); salivary gland: 2.4 nTPM (protected, limit 2); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000100523,DDHD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.126309,-0.214949,-0.34
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 89.5210% (minimum 99%, Missing); amygdala: 83.5196% (minimum 99%, Missing); basal ganglia: 83.9888% (minimum 99%, Missing); bone marrow: 77.6623% (minimum 95%, Enhanced); cerebellum: 77.8646% (minimum 99%, Missing); cerebral cortex: 81.0298% (minimum 99%, Missing); choroid plexus: 93.4375% (minimum 99%, Missing); colon: 88.9881% (minimum 97%, Missing); duodenum: 92.2840% (minimum 99%, Missing); heart muscle: 85.9195% (minimum 99%, Missing); hippocampal formation: 81.6940% (minimum 99%, Missing); hypothalamus: 83.0556% (minimum 99%, Missing); kidney: 93.1464% (minimum 99%, Missing); liver: 92.0000% (minimum 99%, Missing); lung: 85.4286% (minimum 99%, Missing); lymph node: 75.5051% (minimum 80%, Enhanced); midbrain: 79.9465% (minimum 99%, Missing); pancreas: 91.4373% (minimum 99%, Missing); parathyroid gland: 87.4269% (minimum 97%, Missing); pituitary gland: 85.1852% (minimum 99%, Missing); rectum: 86.9186% (minimum 97%, Missing); retina: 65.0000% (minimum 99%, Missing); salivary gland: 92.5697% (minimum 97%, Missing); skeletal muscle: 90.8815% (minimum 95%, Enhanced); skin: 90.0602% (minimum 95%, Missing); small intestine: 86.6667% (minimum 99%, Missing); smooth muscle: 85.9195% (minimum 95%, Enhanced); spinal cord: 76.0814% (minimum 99%, Missing); stomach: 88.9881% (minimum 97%, Missing); thymus: 82.3691% (minimum 95%, Missing); thyroid gland: 89.7898% (minimum 95%, Missing); tongue: 85.4286% (minimum 97%, Missing); urinary bladder: 84.9432% (minimum 97%, Missing)",0,4,partial,16.1,9.7,6.4,"retina: 16.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 6); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thymus: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 2); pituitary gland: 5.2 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 2); lung: 5.1 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); parathyroid gland: 4.3 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000100523,DDHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.126309,-0.120568,-0.34
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,42.3,27.7,30.2,"bone marrow: 42.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); lymph node: 27.7 nTPM (protected, limit 2); rectum: 16.4 nTPM (protected, limit 2); colon: 13.5 nTPM (protected, limit 2); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); stomach: 4.9 nTPM (protected, limit 2); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000100526,CDKN3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.4729% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.6673% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.5351% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.5700% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.8463% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.3370% (minimum 99%, Baseline (adaptation disabled)); colon: 93.6739% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.2480% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.2812% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.5122% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.7160% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.0864% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8625% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.8295% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.5214% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.4179% (minimum 97%, Baseline (adaptation disabled)); retina: 98.8136% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.5700% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.2925% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.5234% (minimum 99%, Baseline (adaptation disabled)); thymus: 86.8753% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,42.3,27.7,30.2,"bone marrow: 42.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); lymph node: 27.7 nTPM (protected, limit 2); rectum: 16.4 nTPM (protected, limit 2); colon: 13.5 nTPM (protected, limit 2); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); stomach: 4.9 nTPM (protected, limit 2); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000100526,CDKN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0812473,-0.0917047,-0.164649
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.4729% (minimum 99%, Missing); basal ganglia: 98.6673% (minimum 99%, Missing); bone marrow: 82.5351% (minimum 99%, Missing); cerebellum: 98.5700% (minimum 99%, Missing); cerebral cortex: 97.8463% (minimum 99%, Missing); choroid plexus: 94.3370% (minimum 99%, Missing); colon: 93.6739% (minimum 97%, Missing); duodenum: 94.2480% (minimum 99%, Missing); esophagus: 95.2812% (minimum 97%, Missing); heart muscle: 97.5122% (minimum 99%, Missing); hippocampal formation: 98.7160% (minimum 99%, Missing); hypothalamus: 98.0864% (minimum 99%, Missing); liver: 98.8625% (minimum 99%, Missing); lymph node: 87.8295% (minimum 97%, Missing); midbrain: 98.5214% (minimum 99%, Missing); rectum: 92.4179% (minimum 97%, Missing); retina: 98.8136% (minimum 99%, Missing); skeletal muscle: 98.5700% (minimum 99%, Missing); small intestine: 94.2925% (minimum 99%, Missing); smooth muscle: 96.5234% (minimum 99%, Missing); thymus: 86.8753% (minimum 95%, Missing)",0,80,unavailable,42.3,27.7,30.2,"bone marrow: 42.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); lymph node: 27.7 nTPM (protected, limit 2); rectum: 16.4 nTPM (protected, limit 2); colon: 13.5 nTPM (protected, limit 2); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 2); heart muscle: 5.1 nTPM (vital, limit 1); stomach: 4.9 nTPM (protected, limit 2); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000100526,CDKN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0812473,-0.0917047,-0.164649
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000100565,LRRC74A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000100565,LRRC74A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.00522388,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000100565,LRRC74A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.00522388,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,14.5,2.3,3.6,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100583,SAMD15,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.7055% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.5455% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.6977% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.7055% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7342% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.6977% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.8710% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.1132% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.9759% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.2281% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.6552% (minimum 99%, Baseline (adaptation disabled)); lung: 95.7055% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.7647% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.7055% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.1429% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.1508% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 51.8272% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.7342% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.7342% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.1132% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.5000% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 81.2500% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.1220% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,14.5,2.3,3.6,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100583,SAMD15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.1375,-0.0984916,-0.471728
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.7055% (minimum 99%, Missing); amygdala: 94.5455% (minimum 99%, Missing); basal ganglia: 90.6977% (minimum 99%, Missing); bone marrow: 95.7055% (minimum 99%, Missing); cerebellum: 98.7342% (minimum 99%, Missing); cerebral cortex: 90.6977% (minimum 99%, Missing); choroid plexus: 83.8710% (minimum 99%, Missing); duodenum: 98.1132% (minimum 99%, Missing); hippocampal formation: 93.9759% (minimum 99%, Missing); hypothalamus: 91.2281% (minimum 99%, Missing); kidney: 89.6552% (minimum 99%, Missing); lung: 95.7055% (minimum 99%, Missing); lymph node: 91.7647% (minimum 97%, Missing); midbrain: 95.7055% (minimum 99%, Missing); pancreas: 89.1429% (minimum 99%, Missing); parathyroid gland: 87.1508% (minimum 97%, Missing); pituitary gland: 86.6667% (minimum 99%, Missing); retina: 51.8272% (minimum 99%, Missing); skeletal muscle: 98.7342% (minimum 99%, Missing); small intestine: 98.7342% (minimum 99%, Missing); smooth muscle: 98.1132% (minimum 99%, Missing); spinal cord: 97.5000% (minimum 99%, Missing); thyroid gland: 81.2500% (minimum 95%, Missing); urinary bladder: 95.1220% (minimum 97%, Missing)",0,0,routine_complete,14.5,2.3,3.6,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100583,SAMD15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.1375,-0.0984916,-0.471728
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,2.1,0.4,0.6,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland,ENSG00000100593,ISM2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.9918% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,2.1,0.4,0.6,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland,ENSG00000100593,ISM2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0470986,0.0280639,-8.16131e-05
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.9918% (minimum 99%, Missing)",0,3,partial,2.1,0.4,0.6,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland,ENSG00000100593,ISM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.029031,-8.16131e-05
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,6.1,4.6,24.2,"thymus: 24.2 nTPM (manageable, limit 5); bone marrow: 6.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100629,CEP128,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.2069% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.7193% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.7193% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 45.0450% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 87.7193% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.2069% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.7193% (minimum 99%, Baseline (adaptation disabled)); colon: 72.4638% (minimum 97%, Baseline (adaptation disabled)); duodenum: 78.1250% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.7576% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.6452% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.2069% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.2857% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.2069% (minimum 99%, Baseline (adaptation disabled)); liver: 84.7458% (minimum 99%, Baseline (adaptation disabled)); lung: 78.1250% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.0833% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.2069% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.2857% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.7576% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.7458% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.7576% (minimum 97%, Baseline (adaptation disabled)); retina: 76.9231% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.6269% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 73.5294% (minimum 99%, Baseline (adaptation disabled)); skin: 68.4932% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.4638% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.4932% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.7576% (minimum 97%, Baseline (adaptation disabled)); thymus: 17.1233% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.7576% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.7458% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.4444% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,6.1,4.6,24.2,"thymus: 24.2 nTPM (manageable, limit 5); bone marrow: 6.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100629,CEP128,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.778767,-0.449167,-0.53955
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Missing); adrenal gland: 86.2069% (minimum 99%, Missing); amygdala: 87.7193% (minimum 99%, Missing); basal ganglia: 87.7193% (minimum 99%, Missing); bone marrow: 45.0450% (minimum 99%, Missing); cerebellum: 87.7193% (minimum 99%, Missing); cerebral cortex: 86.2069% (minimum 99%, Missing); choroid plexus: 87.7193% (minimum 99%, Missing); colon: 72.4638% (minimum 97%, Missing); duodenum: 78.1250% (minimum 99%, Missing); esophagus: 75.7576% (minimum 97%, Missing); heart muscle: 80.6452% (minimum 99%, Missing); hippocampal formation: 86.2069% (minimum 99%, Missing); hypothalamus: 89.2857% (minimum 99%, Missing); kidney: 86.2069% (minimum 99%, Missing); liver: 84.7458% (minimum 99%, Uncertain); lung: 78.1250% (minimum 99%, Missing); lymph node: 52.0833% (minimum 97%, Missing); midbrain: 86.2069% (minimum 99%, Missing); pancreas: 89.2857% (minimum 99%, Missing); parathyroid gland: 75.7576% (minimum 97%, Missing); pituitary gland: 84.7458% (minimum 99%, Missing); rectum: 75.7576% (minimum 97%, Missing); retina: 76.9231% (minimum 99%, Missing); salivary gland: 74.6269% (minimum 97%, Missing); skeletal muscle: 73.5294% (minimum 99%, Missing); skin: 68.4932% (minimum 95%, Missing); small intestine: 83.3333% (minimum 99%, Missing); smooth muscle: 72.4638% (minimum 99%, Missing); spinal cord: 83.3333% (minimum 99%, Missing); spleen: 68.4932% (minimum 95%, Uncertain); stomach: 75.7576% (minimum 97%, Missing); thymus: 17.1233% (minimum 95%, Missing); thyroid gland: 75.7576% (minimum 95%, Missing); tongue: 84.7458% (minimum 97%, Missing); urinary bladder: 69.4444% (minimum 97%, Missing)",0,0,routine_complete,6.1,4.6,24.2,"thymus: 24.2 nTPM (manageable, limit 5); bone marrow: 6.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100629,CEP128,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.778767,-0.449167,-0.53955
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,24.1,20.7,30.2,"thymus: 30.2 nTPM (manageable, limit 5); liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); rectum: 20.1 nTPM (protected, limit 2); colon: 19.3 nTPM (protected, limit 2); parathyroid gland: 18.6 nTPM (protected, limit 2); esophagus: 18.6 nTPM (protected, limit 2); skin: 16.8 nTPM (manageable, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); tongue: 16.5 nTPM (protected, limit 2); thyroid gland: 15.1 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 2); small intestine: 14.1 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); midbrain: 13.3 nTPM (vital, limit 1); heart muscle: 13.3 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 10); salivary gland: 12.7 nTPM (protected, limit 2); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100890,PRORP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0733% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 49.8480% (minimum 99%, Baseline (adaptation disabled)); amygdala: 58.9928% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.3574% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 57.7465% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 69.1983% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 59.6364% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 41.8367% (minimum 99%, Baseline (adaptation disabled)); colon: 45.9384% (minimum 97%, Baseline (adaptation disabled)); duodenum: 52.3962% (minimum 99%, Baseline (adaptation disabled)); esophagus: 46.8571% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 55.2189% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.1940% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.4232% (minimum 99%, Baseline (adaptation disabled)); kidney: 40.5941% (minimum 99%, Baseline (adaptation disabled)); liver: 40.4938% (minimum 99%, Baseline (adaptation disabled)); lung: 57.5439% (minimum 99%, Baseline (adaptation disabled)); lymph node: 44.2049% (minimum 97%, Baseline (adaptation disabled)); midbrain: 55.2189% (minimum 99%, Baseline (adaptation disabled)); pancreas: 61.4232% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 46.8571% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.5659% (minimum 99%, Baseline (adaptation disabled)); rectum: 44.9315% (minimum 97%, Baseline (adaptation disabled)); retina: 73.2143% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.3574% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 52.9032% (minimum 99%, Baseline (adaptation disabled)); skin: 49.3976% (minimum 95%, Baseline (adaptation disabled)); small intestine: 53.7705% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.9928% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 52.2293% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.4054% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.2189% (minimum 97%, Baseline (adaptation disabled)); thymus: 35.1931% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.0635% (minimum 95%, Baseline (adaptation disabled)); tongue: 49.8480% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.5641% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,24.1,20.7,30.2,"thymus: 30.2 nTPM (manageable, limit 5); liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); rectum: 20.1 nTPM (protected, limit 2); colon: 19.3 nTPM (protected, limit 2); parathyroid gland: 18.6 nTPM (protected, limit 2); esophagus: 18.6 nTPM (protected, limit 2); skin: 16.8 nTPM (manageable, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); tongue: 16.5 nTPM (protected, limit 2); thyroid gland: 15.1 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 1); small intestine: 14.1 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); midbrain: 13.3 nTPM (vital, limit 1); heart muscle: 13.3 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); salivary gland: 12.7 nTPM (protected, limit 2); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100890,PRORP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.598069,-0.527951,-0.585062
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0733% (minimum 95%, Missing); adrenal gland: 49.8480% (minimum 99%, Missing); amygdala: 58.9928% (minimum 99%, Missing); basal ganglia: 56.3574% (minimum 99%, Missing); bone marrow: 57.7465% (minimum 99%, Missing); cerebellum: 69.1983% (minimum 99%, Missing); cerebral cortex: 59.6364% (minimum 99%, Missing); choroid plexus: 41.8367% (minimum 99%, Missing); colon: 45.9384% (minimum 97%, Missing); duodenum: 52.3962% (minimum 99%, Missing); esophagus: 46.8571% (minimum 97%, Missing); heart muscle: 55.2189% (minimum 99%, Missing); hippocampal formation: 61.1940% (minimum 99%, Missing); hypothalamus: 61.4232% (minimum 99%, Missing); kidney: 40.5941% (minimum 99%, Missing); liver: 40.4938% (minimum 99%, Missing); lung: 57.5439% (minimum 99%, Missing); lymph node: 44.2049% (minimum 97%, Missing); midbrain: 55.2189% (minimum 99%, Missing); pancreas: 61.4232% (minimum 99%, Missing); parathyroid gland: 46.8571% (minimum 97%, Missing); pituitary gland: 63.5659% (minimum 99%, Missing); rectum: 44.9315% (minimum 97%, Missing); retina: 73.2143% (minimum 99%, Missing); salivary gland: 56.3574% (minimum 97%, Missing); skeletal muscle: 52.9032% (minimum 98%, Approved); skin: 49.3976% (minimum 95%, Missing); small intestine: 53.7705% (minimum 99%, Missing); smooth muscle: 58.9928% (minimum 99%, Missing); spinal cord: 52.2293% (minimum 99%, Missing); spleen: 55.4054% (minimum 90%, Approved); stomach: 55.2189% (minimum 97%, Missing); thymus: 35.1931% (minimum 95%, Missing); thyroid gland: 52.0635% (minimum 95%, Missing); tongue: 49.8480% (minimum 97%, Missing); urinary bladder: 52.5641% (minimum 97%, Missing)",0,6,partial,24.1,20.7,30.2,"thymus: 30.2 nTPM (manageable, limit 5); liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); rectum: 20.1 nTPM (protected, limit 2); colon: 19.3 nTPM (protected, limit 2); parathyroid gland: 18.6 nTPM (protected, limit 2); esophagus: 18.6 nTPM (protected, limit 2); skin: 16.8 nTPM (manageable, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); tongue: 16.5 nTPM (protected, limit 2); thyroid gland: 15.1 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 2); small intestine: 14.1 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); midbrain: 13.3 nTPM (vital, limit 1); heart muscle: 13.3 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 10); salivary gland: 12.7 nTPM (protected, limit 2); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000100890,PRORP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.598069,-0.527951,-0.585062
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,3.8,5,7.1,"thymus: 7.1 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 3.8 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000101003,GINS1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.6170% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.7216% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.7216% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.8413% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.9496% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.1287% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8764% (minimum 99%, Baseline (adaptation disabled)); colon: 72.7273% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.2137% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.2171% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.6237% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.8889% (minimum 99%, Baseline (adaptation disabled)); liver: 88.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 94.6237% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.7681% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.6170% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.6522% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.6522% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.7778% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.1311% (minimum 97%, Baseline (adaptation disabled)); retina: 91.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.7033% (minimum 99%, Baseline (adaptation disabled)); skin: 72.1311% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.8621% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.8095% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.6170% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.2745% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.2430% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.3459% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.6170% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 88.0000% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,3.8,5,7.1,"thymus: 7.1 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 3.8 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000101003,GINS1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.396541,-0.332319,-0.291587
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Uncertain); adrenal gland: 93.6170% (minimum 99%, Missing); amygdala: 90.7216% (minimum 99%, Missing); basal ganglia: 90.7216% (minimum 99%, Missing); bone marrow: 69.8413% (minimum 99%, Missing); cerebellum: 73.9496% (minimum 99%, Missing); cerebral cortex: 87.1287% (minimum 99%, Missing); choroid plexus: 98.8764% (minimum 99%, Missing); colon: 72.7273% (minimum 97%, Missing); duodenum: 75.2137% (minimum 99%, Missing); esophagus: 68.2171% (minimum 97%, Missing); heart muscle: 94.6237% (minimum 99%, Uncertain); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 91.6667% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 88.0000% (minimum 99%, Missing); lung: 94.6237% (minimum 99%, Missing); lymph node: 63.7681% (minimum 97%, Missing); midbrain: 93.6170% (minimum 99%, Missing); pancreas: 95.6522% (minimum 99%, Missing); parathyroid gland: 95.6522% (minimum 97%, Uncertain); pituitary gland: 97.7778% (minimum 99%, Missing); rectum: 72.1311% (minimum 97%, Missing); retina: 91.6667% (minimum 99%, Missing); salivary gland: 91.6667% (minimum 97%, Uncertain); skeletal muscle: 96.7033% (minimum 99%, Uncertain); skin: 72.1311% (minimum 95%, Uncertain); small intestine: 75.8621% (minimum 99%, Missing); smooth muscle: 83.8095% (minimum 99%, Uncertain); spinal cord: 93.6170% (minimum 99%, Missing); spleen: 86.2745% (minimum 95%, Missing); stomach: 82.2430% (minimum 97%, Missing); thymus: 55.3459% (minimum 95%, Missing); thyroid gland: 93.6170% (minimum 95%, Missing); urinary bladder: 88.0000% (minimum 97%, Missing)",0,6,partial,3.8,5,7.1,"thymus: 7.1 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 3.8 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000101003,GINS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.396541,-0.332319,-0.291587
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,90.6,54.2,32.4,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 2); thymus: 32.4 nTPM (manageable, limit 5); spleen: 27.2 nTPM (manageable, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); stomach: 5.9 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000101057,MYBL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.4192% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.1783% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 14.2857% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.7949% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.9686% (minimum 99%, Baseline (adaptation disabled)); colon: 64.5299% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.9498% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.6426% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.4194% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.1783% (minimum 99%, Baseline (adaptation disabled)); liver: 93.2099% (minimum 99%, Baseline (adaptation disabled)); lung: 89.8810% (minimum 99%, Baseline (adaptation disabled)); lymph node: 21.7893% (minimum 97%, Baseline (adaptation disabled)); pancreas: 58.0769% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.6928% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.2661% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 90.9639% (minimum 97%, Baseline (adaptation disabled)); skin: 78.6458% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.5198% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.3041% (minimum 99%, Baseline (adaptation disabled)); spleen: 35.6974% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.9048% (minimum 97%, Baseline (adaptation disabled)); thymus: 31.7895% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 81.6216% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,90.6,54.2,32.4,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 2); thymus: 32.4 nTPM (manageable, limit 5); spleen: 27.2 nTPM (manageable, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); stomach: 5.9 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000101057,MYBL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.632105,-0.752107,-0.847143
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.4192% (minimum 95%, Missing); adrenal gland: 96.1783% (minimum 99%, Missing); bone marrow: 14.2857% (minimum 99%, Missing); cerebral cortex: 96.7949% (minimum 99%, Missing); choroid plexus: 94.9686% (minimum 99%, Missing); colon: 64.5299% (minimum 97%, Missing); duodenum: 68.9498% (minimum 99%, Missing); esophagus: 60.6426% (minimum 97%, Missing); heart muscle: 97.4194% (minimum 99%, Missing); kidney: 96.1783% (minimum 99%, Missing); liver: 93.2099% (minimum 99%, Missing); lung: 89.8810% (minimum 99%, Missing); lymph node: 21.7893% (minimum 97%, Missing); pancreas: 58.0769% (minimum 99%, Missing); pituitary gland: 98.6928% (minimum 99%, Missing); rectum: 69.2661% (minimum 97%, Missing); salivary gland: 90.9639% (minimum 97%, Missing); skin: 78.6458% (minimum 95%, Missing); small intestine: 66.5198% (minimum 99%, Missing); smooth muscle: 88.3041% (minimum 99%, Missing); spleen: 35.6974% (minimum 95%, Missing); stomach: 71.9048% (minimum 97%, Missing); thymus: 31.7895% (minimum 95%, Missing); urinary bladder: 81.6216% (minimum 97%, Missing)",0,1,partial,90.6,54.2,32.4,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 2); thymus: 32.4 nTPM (manageable, limit 5); spleen: 27.2 nTPM (manageable, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); stomach: 5.9 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000101057,MYBL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.632105,-0.752107,-0.847143
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,9,partial,2.3,0.7,0.1,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),75,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; appendix / goblet cells; skin,ENSG00000101074,R3HDML,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 80.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 36.3636% (minimum 97%, Baseline (adaptation disabled)); duodenum: 16.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 57.1429% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 80.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 14.8148% (minimum 99%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,2.3,0.7,0.1,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),75,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; appendix / goblet cells; skin,ENSG00000101074,R3HDML,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.15,-0.606364,-0.841852
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 80.0000% (minimum 95%, Enhanced); colon: 36.3636% (minimum 97%, Missing); duodenum: 16.0000% (minimum 99%, Missing); hypothalamus: 57.1429% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 80.0000% (minimum 95%, Enhanced); lung: 80.0000% (minimum 95%, Enhanced); retina: 80.0000% (minimum 99%, Missing); small intestine: 14.8148% (minimum 99%, Missing); stomach: 50.0000% (minimum 80%, Enhanced)",0,9,partial,2.3,0.7,0.1,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),75,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; appendix / goblet cells; skin,ENSG00000101074,R3HDML,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.606364,-0.841852
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9,0.2,0.6,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000101203,COL20A1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 24.2424% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 35.8209% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.8140% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 21.0526% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 28.5714% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 42.8571% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 32.4324% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 70.5882% (minimum 99%, Baseline (adaptation disabled)); retina: 96.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 36.3636% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.3077% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9,0.2,0.6,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000101203,COL20A1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.15,-0.0469231,-0.779474
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.0000% (minimum 99%, Missing); amygdala: 24.2424% (minimum 99%, Missing); basal ganglia: 35.8209% (minimum 99%, Missing); cerebellum: 55.8140% (minimum 99%, Missing); cerebral cortex: 21.0526% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); hippocampal formation: 28.5714% (minimum 99%, Missing); hypothalamus: 42.8571% (minimum 99%, Missing); kidney: 96.0000% (minimum 99%, Missing); midbrain: 32.4324% (minimum 99%, Missing); pituitary gland: 70.5882% (minimum 99%, Missing); retina: 96.0000% (minimum 99%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); skeletal muscle: 96.0000% (minimum 99%, Missing); spinal cord: 36.3636% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); tongue: 92.3077% (minimum 97%, Missing)",0,80,unavailable,9,0.2,0.6,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000101203,COL20A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.15,-0.0469231,-0.779474
True,compatible,,True,True,False,,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000101251,SEL1L2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"smooth muscle: 98.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5714% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000101251,SEL1L2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.00428571
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"spinal cord: 98.5714% (minimum 99%, Missing)",0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000101251,SEL1L2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.00428571
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,18.6,11.1,2.3,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 4); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); midbrain: 6.4 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 2); spinal cord: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); cerebral cortex: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000101276,SLC52A3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 94.4712% (minimum 95%, Baseline (adaptation disabled)); amygdala: 89.7260% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.9195% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.6988% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.9140% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7612% (minimum 99%, Baseline (adaptation disabled)); colon: 77.9762% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.8722% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.7133% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.9469% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.3146% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.7133% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.3939% (minimum 99%, Baseline (adaptation disabled)); lung: 97.0370% (minimum 99%, Baseline (adaptation disabled)); midbrain: 85.9956% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.0880% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.0649% (minimum 97%, Baseline (adaptation disabled)); retina: 98.4962% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 86.9469% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.4962% (minimum 99%, Baseline (adaptation disabled)); small intestine: 67.8756% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.0880% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.9195% (minimum 99%, Baseline (adaptation disabled)); stomach: 87.9195% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.3182% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,18.6,11.1,2.3,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 2); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); midbrain: 6.4 nTPM (vital, limit 1); salivary gland: 5.9 nTPM (protected, limit 2); heart muscle: 5.9 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); basal ganglia: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); hypothalamus: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000101276,SLC52A3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00528846,-0.190238,-0.311244
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 89.7260% (minimum 99%, Missing); basal ganglia: 87.9195% (minimum 99%, Missing); cerebellum: 94.6988% (minimum 99%, Missing); cerebral cortex: 88.9140% (minimum 99%, Missing); choroid plexus: 97.7612% (minimum 99%, Missing); colon: 77.9762% (minimum 95%, Approved); duodenum: 73.8722% (minimum 99%, Missing); esophagus: 88.7133% (minimum 97%, Missing); heart muscle: 86.9469% (minimum 98%, Approved); hippocampal formation: 88.3146% (minimum 99%, Missing); hypothalamus: 88.7133% (minimum 99%, Missing); kidney: 79.3939% (minimum 99%, Missing); lung: 97.0370% (minimum 98%, Approved); midbrain: 85.9956% (minimum 99%, Missing); pancreas: 96.0880% (minimum 98%, Approved); rectum: 85.0649% (minimum 97%, Missing); retina: 98.4962% (minimum 99%, Missing); salivary gland: 86.9469% (minimum 97%, Missing); small intestine: 67.8756% (minimum 99%, Missing); smooth muscle: 96.0880% (minimum 98%, Approved); spinal cord: 87.9195% (minimum 99%, Missing); stomach: 87.9195% (minimum 97%, Missing); urinary bladder: 89.3182% (minimum 97%, Missing)",0,1,partial,18.6,11.1,2.3,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 4); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); midbrain: 6.4 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 2); spinal cord: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); cerebral cortex: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000101276,SLC52A3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0349624,-0.170238,-0.311244
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,5.6,4.1,1.9,"skeletal muscle: 5.6 nTPM (vital, limit 2); tongue: 4.1 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000101353,MROH8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.2990% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.2990% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7672% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.7644% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.7914% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.2990% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.8205% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.6029% (minimum 99%, Baseline (adaptation disabled)); colon: 93.7824% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.7672% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.2766% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.6040% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.2766% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.2708% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.4141% (minimum 99%, Baseline (adaptation disabled)); liver: 90.9548% (minimum 99%, Baseline (adaptation disabled)); lung: 96.7914% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.7824% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.7672% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.8782% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.8782% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.4141% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.2632% (minimum 97%, Baseline (adaptation disabled)); retina: 82.2727% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.7644% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.3713% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.7914% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.2766% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.7644% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.2632% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.8205% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.5000% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.5315% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.7672% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,5.6,4.1,1.9,"skeletal muscle: 5.6 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000101353,MROH8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.045,-0.154685,-0.226287
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.2990% (minimum 99%, Missing); amygdala: 95.7672% (minimum 99%, Missing); basal ganglia: 94.7644% (minimum 99%, Missing); bone marrow: 96.7914% (minimum 98%, Approved); cerebellum: 93.2990% (minimum 99%, Missing); cerebral cortex: 92.8205% (minimum 99%, Missing); choroid plexus: 86.6029% (minimum 99%, Missing); colon: 93.7824% (minimum 97%, Missing); duodenum: 95.7672% (minimum 99%, Missing); heart muscle: 89.6040% (minimum 99%, Missing); hippocampal formation: 96.2766% (minimum 99%, Missing); hypothalamus: 94.2708% (minimum 99%, Missing); kidney: 91.4141% (minimum 99%, Missing); liver: 90.9548% (minimum 98%, Approved); lung: 96.7914% (minimum 98%, Approved); lymph node: 93.7824% (minimum 95%, Approved); midbrain: 95.7672% (minimum 99%, Missing); pancreas: 91.8782% (minimum 98%, Approved); parathyroid gland: 91.8782% (minimum 95%, Approved); pituitary gland: 91.4141% (minimum 99%, Missing); retina: 82.2727% (minimum 99%, Missing); salivary gland: 94.7644% (minimum 97%, Missing); skeletal muscle: 76.3713% (minimum 98%, Approved); small intestine: 96.7914% (minimum 98%, Approved); smooth muscle: 90.5000% (minimum 98%, Approved); spinal cord: 96.2766% (minimum 99%, Missing); thymus: 92.8205% (minimum 95%, Missing); thyroid gland: 90.5000% (minimum 95%, Missing); tongue: 81.5315% (minimum 97%, Missing)",0,1,partial,5.6,4.1,1.9,"skeletal muscle: 5.6 nTPM (vital, limit 2); tongue: 4.1 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000101353,MROH8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.045,-0.154685,-0.216287
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000101435,CST9L,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000101435,CST9L,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000101435,CST9L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,False,,0,8,partial,0,0,1.2,,skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced),66,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes,ENSG00000101446,SPINT3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"skin: 89.5652% (minimum 95%, Baseline (adaptation disabled))",0,8,partial,0,0,1.2,,skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced),66,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes,ENSG00000101446,SPINT3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.0543478,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"skin: 89.5652% (minimum 95%, Missing)",0,8,partial,0,0,1.2,,skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced),66,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes,ENSG00000101446,SPINT3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.0543478,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,2.3,0.4,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000101448,EPPIN,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,2.3,0.4,0.7,"bone marrow: 2.3 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000101448,EPPIN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0478152,0.0287504,0.00285714
True,compatible,,True,True,True,,0,1,partial,2.3,0.4,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000101448,EPPIN,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.0075039
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.4,0.7,1.5,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; tonsil,ENSG00000101746,NOL4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 87.7698% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.8743% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.3732% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.9823% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 54.9550% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.0630% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.5393% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.3065% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.5736% (minimum 99%, Baseline (adaptation disabled)); liver: 85.3147% (minimum 99%, Baseline (adaptation disabled)); lung: 98.3871% (minimum 99%, Baseline (adaptation disabled)); midbrain: 81.8792% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.4058% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 61.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.5736% (minimum 97%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.0511% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.5736% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 89.0511% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.0630% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.4,0.7,1.5,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; tonsil,ENSG00000101746,NOL4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0594891,-0.0242636,-0.450177
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 87.7698% (minimum 99%, Missing); amygdala: 63.8743% (minimum 99%, Missing); basal ganglia: 58.3732% (minimum 99%, Missing); cerebellum: 53.9823% (minimum 99%, Missing); cerebral cortex: 54.9550% (minimum 99%, Missing); choroid plexus: 96.0630% (minimum 99%, Missing); hippocampal formation: 68.5393% (minimum 99%, Missing); hypothalamus: 61.3065% (minimum 99%, Missing); kidney: 94.5736% (minimum 99%, Missing); liver: 85.3147% (minimum 99%, Missing); lung: 98.3871% (minimum 99%, Missing); midbrain: 81.8792% (minimum 99%, Missing); pancreas: 88.4058% (minimum 99%, Missing); pituitary gland: 61.0000% (minimum 99%, Missing); rectum: 94.5736% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); spinal cord: 89.0511% (minimum 99%, Missing); stomach: 94.5736% (minimum 97%, Missing); thyroid gland: 89.0511% (minimum 95%, Missing); urinary bladder: 96.0630% (minimum 97%, Missing)",0,80,unavailable,10.4,0.7,1.5,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; tonsil,ENSG00000101746,NOL4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0594891,-0.0242636,-0.450177
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1,0.7,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101812,H2BW2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 88.4615% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.4615% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.8333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.3103% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.4615% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.1429% (minimum 99%, Baseline (adaptation disabled)); colon: 92.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.8333% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.8333% (minimum 99%, Baseline (adaptation disabled)); lung: 92.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.6667% (minimum 97%, Baseline (adaptation disabled)); parathyroid gland: 88.4615% (minimum 97%, Baseline (adaptation disabled)); rectum: 88.4615% (minimum 97%, Baseline (adaptation disabled)); retina: 76.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.4615% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 76.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.6970% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.1429% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.7619% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.3103% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.1852% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1,0.7,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101812,H2BW2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,-0.402381,-0.203333,-0.29303
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 88.4615% (minimum 95%, Missing); adrenal gland: 88.4615% (minimum 99%, Missing); basal ganglia: 95.8333% (minimum 99%, Missing); bone marrow: 79.3103% (minimum 99%, Missing); cerebral cortex: 88.4615% (minimum 99%, Missing); choroid plexus: 82.1429% (minimum 99%, Missing); colon: 92.0000% (minimum 97%, Missing); duodenum: 92.0000% (minimum 99%, Missing); esophagus: 92.0000% (minimum 97%, Missing); heart muscle: 95.8333% (minimum 99%, Missing); kidney: 95.8333% (minimum 99%, Missing); lung: 92.0000% (minimum 99%, Missing); lymph node: 76.6667% (minimum 97%, Missing); parathyroid gland: 88.4615% (minimum 97%, Missing); rectum: 88.4615% (minimum 97%, Missing); retina: 76.6667% (minimum 99%, Missing); salivary gland: 88.4615% (minimum 97%, Missing); skeletal muscle: 92.0000% (minimum 99%, Missing); skin: 76.6667% (minimum 95%, Missing); small intestine: 92.0000% (minimum 99%, Missing); smooth muscle: 69.6970% (minimum 99%, Missing); spleen: 82.1429% (minimum 95%, Missing); stomach: 92.0000% (minimum 97%, Missing); thymus: 54.7619% (minimum 95%, Missing); tongue: 79.3103% (minimum 97%, Missing); urinary bladder: 85.1852% (minimum 97%, Missing)",0,80,unavailable,1,0.7,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101812,H2BW2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,-0.402381,-0.203333,-0.29303
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,2.5,188.6,0.8,"stomach: 188.6 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101842,VSIG1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.2979% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.4684% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0892% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.2500% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.8665% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9293% (minimum 99%, Baseline (adaptation disabled)); stomach: 19.6763% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.3066% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,2.5,188.6,0.8,"stomach: 188.6 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101842,VSIG1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0329787,-0.773237,-0.0413347
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.2979% (minimum 99%, Missing); duodenum: 97.4684% (minimum 99%, Missing); pituitary gland: 94.8665% (minimum 99%, Missing); stomach: 19.6763% (minimum 97%, Missing); urinary bladder: 84.3066% (minimum 97%, Missing)",0,4,partial,2.5,188.6,0.8,"stomach: 188.6 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101842,VSIG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0350746,-0.773237,-0.0413347
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,12.6,1.7,1.6,"cerebellum: 12.6 nTPM (vital, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101883,RHOXF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.1235% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.9936% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.5706% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.4848% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.6765% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.9545% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.3478% (minimum 99%, Baseline (adaptation disabled)); colon: 89.5706% (minimum 97%, Baseline (adaptation disabled)); esophagus: 96.6887% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.0526% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.5706% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.7814% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.5706% (minimum 99%, Baseline (adaptation disabled)); liver: 94.1935% (minimum 99%, Baseline (adaptation disabled)); lung: 96.6887% (minimum 99%, Baseline (adaptation disabled)); midbrain: 90.1235% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6486% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 89.5706% (minimum 99%, Baseline (adaptation disabled)); retina: 85.3801% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0526% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.6486% (minimum 99%, Baseline (adaptation disabled)); skin: 92.4051% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.5897% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.4051% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.8239% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.4248% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.9936% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.5897% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,12.6,1.7,1.6,"cerebellum: 12.6 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101883,RHOXF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0487654,-0.0742945,-0.453235
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.9936% (minimum 98%, Approved); amygdala: 89.5706% (minimum 99%, Missing); basal ganglia: 88.4848% (minimum 99%, Missing); cerebellum: 53.6765% (minimum 98%, Approved); cerebral cortex: 82.9545% (minimum 98%, Approved); choroid plexus: 79.3478% (minimum 99%, Missing); colon: 89.5706% (minimum 97%, Missing); heart muscle: 96.0526% (minimum 98%, Approved); hippocampal formation: 89.5706% (minimum 99%, Missing); hypothalamus: 79.7814% (minimum 99%, Missing); kidney: 89.5706% (minimum 98%, Approved); liver: 94.1935% (minimum 98%, Approved); lung: 96.6887% (minimum 98%, Approved); midbrain: 90.1235% (minimum 99%, Missing); pituitary gland: 89.5706% (minimum 99%, Missing); retina: 85.3801% (minimum 99%, Missing); small intestine: 93.5897% (minimum 98%, Approved); spinal cord: 92.4051% (minimum 99%, Missing); urinary bladder: 93.5897% (minimum 95%, Approved)",0,2,partial,12.6,1.7,1.6,"cerebellum: 12.6 nTPM (vital, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101883,RHOXF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00123457,-0.0742945,-0.443235
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,40.9,0,0.2,"retina: 40.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000101890,GUCY2F,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"retina: 0.4866% (minimum 99%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,40.9,0,0.2,"retina: 40.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000101890,GUCY2F,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.45,0.03,-0.985134
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"retina: 0.4866% (minimum 99%, Missing); thymus: 50.0000% (minimum 95%, Missing)",0,80,unavailable,40.9,0,0.2,"retina: 40.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000101890,GUCY2F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.45,0.03,-0.985134
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,0,routine_complete,23.3,0.6,0.3,"smooth muscle: 23.3 nTPM (vital, limit 6); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,ENSG00000101951,PAGE4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"smooth muscle: 97.6940% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,23.3,0.6,0.3,"smooth muscle: 23.3 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,ENSG00000101951,PAGE4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0496962,0.0293925,-0.0130602
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,0,routine_complete,23.3,0.6,0.3,"smooth muscle: 23.3 nTPM (vital, limit 6); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,ENSG00000101951,PAGE4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0498987,0.03,0.00828074
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,23.2,1,1.1,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101977,MCF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.7863% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.5158% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.0784% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.2155% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.0253% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.4545% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.2308% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.0588% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.8935% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.3043% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6577% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.7105% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.7647% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6577% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 81.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 62.2881% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.6306% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.1233% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.6306% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.0380% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,23.2,1,1.1,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101977,MCF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0196203,-0.0336943,-0.602137
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.7863% (minimum 99%, Missing); amygdala: 73.5000% (minimum 99%, Missing); basal ganglia: 66.5158% (minimum 99%, Missing); bone marrow: 96.0784% (minimum 99%, Missing); cerebellum: 81.2155% (minimum 99%, Missing); cerebral cortex: 62.0253% (minimum 99%, Missing); choroid plexus: 95.4545% (minimum 99%, Missing); heart muscle: 94.2308% (minimum 99%, Missing); hippocampal formation: 72.0588% (minimum 99%, Missing); hypothalamus: 55.8935% (minimum 99%, Missing); kidney: 91.3043% (minimum 99%, Missing); liver: 98.6577% (minimum 99%, Missing); lymph node: 96.7105% (minimum 97%, Missing); midbrain: 61.7647% (minimum 99%, Missing); pancreas: 98.6577% (minimum 99%, Missing); pituitary gland: 81.6667% (minimum 99%, Missing); retina: 62.2881% (minimum 99%, Missing); salivary gland: 93.6306% (minimum 97%, Missing); small intestine: 98.0000% (minimum 99%, Missing); spinal cord: 67.1233% (minimum 99%, Missing); spleen: 93.6306% (minimum 95%, Missing); thyroid gland: 93.0380% (minimum 95%, Missing)",0,80,unavailable,23.2,1,1.1,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000101977,MCF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0196203,-0.0336943,-0.602137
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000102021,LUZP4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000102021,LUZP4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000102021,LUZP4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,16.9,4,11.4,"liver: 16.9 nTPM (vital, limit 6); kidney: 16.2 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102048,ASB9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.9414% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.9112% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.8189% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.6058% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.8189% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.4314% (minimum 99%, Baseline (adaptation disabled)); colon: 94.0075% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.0075% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.7170% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.6058% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8189% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.7748% (minimum 99%, Baseline (adaptation disabled)); liver: 59.7619% (minimum 99%, Baseline (adaptation disabled)); lung: 88.0702% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.5385% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.8189% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.9651% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.4314% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.6058% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 87.4564% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.0469% (minimum 99%, Baseline (adaptation disabled)); skin: 93.3086% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.5385% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.9414% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8189% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.7671% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.2543% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.5517% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.2794% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.0758% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.0758% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,16.9,4,11.4,"liver: 16.9 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 9.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); salivary gland: 3.6 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102048,ASB9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.262329,-0.107457,-0.392381
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.8189% (minimum 99%, Missing); bone marrow: 91.6058% (minimum 95%, Enhanced); choroid plexus: 98.4314% (minimum 99%, Missing); duodenum: 94.0075% (minimum 95%, Enhanced); heart muscle: 91.6058% (minimum 95%, Enhanced); hippocampal formation: 98.8189% (minimum 99%, Missing); kidney: 60.7748% (minimum 99%, Missing); liver: 59.7619% (minimum 95%, Enhanced); lung: 88.0702% (minimum 95%, Enhanced); midbrain: 98.8189% (minimum 99%, Missing); pancreas: 72.9651% (minimum 99%, Missing); pituitary gland: 98.4314% (minimum 99%, Missing); skin: 93.3086% (minimum 95%, Missing); smooth muscle: 91.9414% (minimum 95%, Enhanced); spinal cord: 98.8189% (minimum 99%, Missing); thymus: 86.5517% (minimum 95%, Missing); tongue: 95.0758% (minimum 97%, Missing)",0,6,partial,16.9,4,11.4,"liver: 16.9 nTPM (vital, limit 6); kidney: 16.2 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102048,ASB9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0844828,-0.0192424,-0.382252
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil,ENSG00000102055,PPP1R2C,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil,ENSG00000102055,PPP1R2C,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0471098,0.0285528,0.005671
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil,ENSG00000102055,PPP1R2C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0471098,0.0285528,0.005671
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,248.2,0,0,"retina: 248.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000102076,OPN1LW,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,248.2,0,0,"retina: 248.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000102076,OPN1LW,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,248.2,0,0,"retina: 248.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000102076,OPN1LW,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,6.2,8.5,3.3,"bone marrow: 6.2 nTPM (vital, limit 6); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102098,SCML2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 88.8889% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.1722% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.1176% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.3678% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.6000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.3226% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 86.1538% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.0569% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.8033% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.5620% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.1176% (minimum 99%, Baseline (adaptation disabled)); liver: 89.6000% (minimum 99%, Baseline (adaptation disabled)); lung: 95.7265% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.0569% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.1176% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.6000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.5000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.3226% (minimum 97%, Baseline (adaptation disabled)); retina: 76.7123% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.8528% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.6000% (minimum 99%, Baseline (adaptation disabled)); skin: 85.4962% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.5620% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.3529% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.5620% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.0569% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.9153% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.2414% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.9630% (minimum 95%, Baseline (adaptation disabled)); tongue: 89.6000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.6000% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,6.2,8.5,3.3,"salivary gland: 8.5 nTPM (protected, limit 2); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102098,SCML2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.177586,-0.401472,-0.346322
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 74.1722% (minimum 95%, Enhanced); amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); bone marrow: 64.3678% (minimum 95%, Enhanced); cerebellum: 89.6000% (minimum 95%, Enhanced); cerebral cortex: 90.3226% (minimum 95%, Enhanced); choroid plexus: 93.3333% (minimum 99%, Missing); colon: 86.1538% (minimum 97%, Missing); duodenum: 91.0569% (minimum 95%, Enhanced); esophagus: 91.8033% (minimum 97%, Missing); heart muscle: 94.1176% (minimum 95%, Enhanced); hippocampal formation: 92.5620% (minimum 99%, Missing); hypothalamus: 93.3333% (minimum 99%, Missing); kidney: 94.1176% (minimum 99%, Missing); liver: 89.6000% (minimum 95%, Enhanced); lung: 95.7265% (minimum 99%, Missing); midbrain: 94.1176% (minimum 99%, Missing); pancreas: 89.6000% (minimum 95%, Enhanced); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 90.3226% (minimum 97%, Missing); retina: 76.7123% (minimum 99%, Missing); salivary gland: 56.8528% (minimum 80%, Enhanced); skeletal muscle: 89.6000% (minimum 95%, Enhanced); small intestine: 92.5620% (minimum 99%, Missing); smooth muscle: 82.3529% (minimum 95%, Enhanced); spinal cord: 92.5620% (minimum 99%, Missing); thymus: 77.2414% (minimum 95%, Missing); thyroid gland: 82.9630% (minimum 95%, Missing); tongue: 89.6000% (minimum 97%, Missing)",0,5,partial,6.2,8.5,3.3,"bone marrow: 6.2 nTPM (vital, limit 6); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102098,SCML2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.177586,-0.231472,-0.306322
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,6.4,21.9,0.6,"urinary bladder: 21.9 nTPM (protected, limit 6); kidney: 6.4 nTPM (vital, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102243,VGLL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 96.8519% (minimum 99%, Baseline (adaptation disabled)); lung: 98.9447% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 89.9909% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,6.4,21.9,0.6,"urinary bladder: 21.9 nTPM (protected, limit 2); kidney: 6.4 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102243,VGLL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,0.046962,-0.0700914,-0.0214806
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 96.8519% (minimum 97%, Supported); urinary bladder: 89.9909% (minimum 90%, Supported)",0,2,partial,6.4,21.9,0.6,"urinary bladder: 21.9 nTPM (protected, limit 6); kidney: 6.4 nTPM (vital, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102243,VGLL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,0.0489853,-9.14077e-05,-0.00148057
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,2.8,4.3,1.9,"salivary gland: 4.3 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000102383,ZDHHC15,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.8621% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 59.4595% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.7500% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.6522% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.1111% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 44.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 70.9677% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.8947% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.7500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.6585% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.4595% (minimum 99%, Baseline (adaptation disabled)); liver: 95.6522% (minimum 99%, Baseline (adaptation disabled)); lung: 66.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.7500% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.7500% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.4815% (minimum 97%, Baseline (adaptation disabled)); retina: 53.6585% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 33.8462% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 75.8621% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.1111% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.8571% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.8621% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.6154% (minimum 97%, Baseline (adaptation disabled)); thymus: 73.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.6585% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.4815% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.5714% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,2.8,4.3,1.9,"salivary gland: 4.3 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000102383,ZDHHC15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.413415,-0.631538,-0.55
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.8621% (minimum 90%, Approved); adrenal gland: 59.4595% (minimum 99%, Missing); amygdala: 68.7500% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 95.6522% (minimum 99%, Missing); cerebellum: 61.1111% (minimum 99%, Missing); cerebral cortex: 44.0000% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 70.9677% (minimum 97%, Missing); duodenum: 91.6667% (minimum 99%, Missing); esophagus: 73.3333% (minimum 97%, Missing); heart muscle: 57.8947% (minimum 99%, Missing); hippocampal formation: 68.7500% (minimum 99%, Missing); hypothalamus: 53.6585% (minimum 99%, Missing); kidney: 59.4595% (minimum 99%, Missing); liver: 95.6522% (minimum 99%, Missing); lung: 66.6667% (minimum 99%, Missing); lymph node: 88.0000% (minimum 95%, Approved); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 68.7500% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 68.7500% (minimum 99%, Missing); rectum: 81.4815% (minimum 97%, Missing); retina: 53.6585% (minimum 99%, Missing); salivary gland: 33.8462% (minimum 97%, Missing); skeletal muscle: 88.0000% (minimum 99%, Missing); skin: 75.8621% (minimum 95%, Missing); small intestine: 88.0000% (minimum 99%, Missing); smooth muscle: 61.1111% (minimum 98%, Approved); spinal cord: 62.8571% (minimum 99%, Missing); spleen: 75.8621% (minimum 90%, Approved); stomach: 84.6154% (minimum 97%, Missing); thymus: 73.3333% (minimum 95%, Missing); thyroid gland: 53.6585% (minimum 95%, Missing); tongue: 81.4815% (minimum 97%, Missing); urinary bladder: 78.5714% (minimum 97%, Missing)",0,4,partial,2.8,4.3,1.9,"salivary gland: 4.3 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000102383,ZDHHC15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.413415,-0.631538,-0.55
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.5,4.3,5.2,"bone marrow: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102384,CENPI,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.3636% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.4762% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.4762% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 25.6757% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.3704% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.4762% (minimum 99%, Baseline (adaptation disabled)); colon: 48.7179% (minimum 97%, Baseline (adaptation disabled)); duodenum: 44.1860% (minimum 99%, Baseline (adaptation disabled)); esophagus: 48.7179% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.6087% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.4762% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.4762% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.6087% (minimum 99%, Baseline (adaptation disabled)); liver: 73.0769% (minimum 99%, Baseline (adaptation disabled)); lung: 73.0769% (minimum 99%, Baseline (adaptation disabled)); lymph node: 30.6452% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.4762% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.3636% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.4762% (minimum 97%, Baseline (adaptation disabled)); rectum: 41.3043% (minimum 97%, Baseline (adaptation disabled)); retina: 48.7179% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.3636% (minimum 99%, Baseline (adaptation disabled)); skin: 37.2549% (minimum 95%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 51.3514% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.6087% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.8824% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.2903% (minimum 97%, Baseline (adaptation disabled)); thymus: 26.7606% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 76.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.1667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.5172% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.5,4.3,5.2,"bone marrow: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102384,CENPI,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.682394,-0.663548,-0.733243
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Missing); adrenal gland: 86.3636% (minimum 99%, Missing); amygdala: 90.4762% (minimum 99%, Missing); basal ganglia: 90.4762% (minimum 99%, Missing); bone marrow: 25.6757% (minimum 99%, Missing); cerebellum: 95.0000% (minimum 99%, Missing); cerebral cortex: 70.3704% (minimum 99%, Missing); choroid plexus: 90.4762% (minimum 99%, Missing); colon: 48.7179% (minimum 97%, Missing); duodenum: 44.1860% (minimum 99%, Missing); esophagus: 48.7179% (minimum 97%, Missing); heart muscle: 82.6087% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 90.4762% (minimum 99%, Missing); kidney: 82.6087% (minimum 99%, Missing); liver: 73.0769% (minimum 99%, Missing); lung: 73.0769% (minimum 99%, Missing); lymph node: 30.6452% (minimum 97%, Missing); midbrain: 90.4762% (minimum 99%, Missing); pancreas: 86.3636% (minimum 99%, Missing); parathyroid gland: 90.4762% (minimum 97%, Missing); rectum: 41.3043% (minimum 97%, Missing); retina: 48.7179% (minimum 99%, Missing); salivary gland: 76.0000% (minimum 97%, Missing); skeletal muscle: 86.3636% (minimum 99%, Missing); skin: 37.2549% (minimum 95%, Missing); small intestine: 50.0000% (minimum 99%, Missing); smooth muscle: 51.3514% (minimum 99%, Missing); spinal cord: 82.6087% (minimum 99%, Missing); spleen: 55.8824% (minimum 95%, Missing); stomach: 61.2903% (minimum 97%, Missing); thymus: 26.7606% (minimum 95%, Missing); thyroid gland: 76.0000% (minimum 95%, Missing); tongue: 79.1667% (minimum 97%, Missing); urinary bladder: 65.5172% (minimum 97%, Missing)",0,80,unavailable,5.5,4.3,5.2,"bone marrow: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102384,CENPI,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.682394,-0.663548,-0.733243
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,3.9,3.8,0.9,"choroid plexus: 3.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,ENSG00000102387,TAF7L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.8454% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.4615% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.4603% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.7283% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.5409% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.3974% (minimum 99%, Baseline (adaptation disabled)); liver: 96.8454% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.9855% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,3.9,3.8,0.9,"choroid plexus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,ENSG00000102387,TAF7L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.021519,-0.0801449,-0.102717
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.8454% (minimum 99%, Missing); basal ganglia: 94.4615% (minimum 99%, Missing); cerebral cortex: 97.4603% (minimum 98%, Approved); choroid plexus: 88.7283% (minimum 99%, Missing); hippocampal formation: 96.5409% (minimum 99%, Missing); liver: 96.8454% (minimum 98%, Approved); parathyroid gland: 88.9855% (minimum 95%, Approved)",0,4,partial,3.9,3.8,0.9,"choroid plexus: 3.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,ENSG00000102387,TAF7L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.0467532,-0.0601449,-0.102717
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,9.2,5.3,9.1,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (manageable, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 2); retina: 5.1 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); cerebral cortex: 4.7 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 2); choroid plexus: 4.5 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); lymph node: 3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000102543,CDADC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.2903% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 53.5211% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.9573% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 67.8571% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.0725% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.0725% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.7886% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.8099% (minimum 99%, Baseline (adaptation disabled)); colon: 62.2951% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.6981% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.0280% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.4068% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.5172% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.8099% (minimum 99%, Baseline (adaptation disabled)); kidney: 45.2381% (minimum 99%, Baseline (adaptation disabled)); liver: 49.0323% (minimum 99%, Baseline (adaptation disabled)); lung: 69.0909% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.6981% (minimum 97%, Baseline (adaptation disabled)); midbrain: 65.5172% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.5098% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.9147% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.3704% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.0280% (minimum 97%, Baseline (adaptation disabled)); retina: 59.8425% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.7248% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.8655% (minimum 99%, Baseline (adaptation disabled)); skin: 77.5510% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.3810% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.4685% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.5172% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.4068% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 45.5090% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.3175% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.0909% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,9.2,5.3,9.1,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (manageable, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 2); retina: 5.1 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); cerebral cortex: 4.7 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 2); choroid plexus: 4.5 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); lymph node: 3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000102543,CDADC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.49491,-0.380853,-0.537619
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.2903% (minimum 95%, Uncertain); adrenal gland: 53.5211% (minimum 99%, Uncertain); amygdala: 64.9573% (minimum 99%, Missing); basal ganglia: 67.8571% (minimum 99%, Missing); bone marrow: 55.0725% (minimum 99%, Missing); cerebellum: 55.0725% (minimum 99%, Uncertain); cerebral cortex: 61.7886% (minimum 99%, Uncertain); choroid plexus: 62.8099% (minimum 99%, Missing); colon: 62.2951% (minimum 97%, Missing); duodenum: 71.6981% (minimum 99%, Uncertain); esophagus: 71.0280% (minimum 97%, Uncertain); heart muscle: 64.4068% (minimum 99%, Uncertain); hippocampal formation: 65.5172% (minimum 99%, Missing); hypothalamus: 62.8099% (minimum 99%, Missing); kidney: 45.2381% (minimum 99%, Uncertain); liver: 49.0323% (minimum 99%, Uncertain); lung: 69.0909% (minimum 99%, Uncertain); lymph node: 71.6981% (minimum 97%, Missing); midbrain: 65.5172% (minimum 99%, Missing); pancreas: 74.5098% (minimum 99%, Uncertain); parathyroid gland: 58.9147% (minimum 97%, Uncertain); pituitary gland: 70.3704% (minimum 99%, Missing); rectum: 71.0280% (minimum 97%, Uncertain); retina: 59.8425% (minimum 99%, Missing); salivary gland: 69.7248% (minimum 97%, Uncertain); skeletal muscle: 63.8655% (minimum 99%, Uncertain); skin: 77.5510% (minimum 95%, Uncertain); small intestine: 72.3810% (minimum 99%, Uncertain); smooth muscle: 67.8571% (minimum 99%, Uncertain); spinal cord: 68.4685% (minimum 99%, Missing); spleen: 65.5172% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Uncertain); thymus: 64.4068% (minimum 95%, Missing); thyroid gland: 45.5090% (minimum 95%, Uncertain); tongue: 60.3175% (minimum 97%, Missing); urinary bladder: 69.0909% (minimum 97%, Uncertain)",0,4,partial,9.2,5.3,9.1,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (manageable, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 2); retina: 5.1 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); cerebral cortex: 4.7 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 2); choroid plexus: 4.5 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); lymph node: 3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000102543,CDADC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.49491,-0.380853,-0.537619
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.3,8,11.4,"adipose tissue: 11.4 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 2); salivary gland: 7.8 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); retina: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102595,UGGT2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.7778% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.9552% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.3920% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.8290% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.8290% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.4132% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.6411% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 70.2703% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.4124% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.2857% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.9336% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.1223% (minimum 99%, Baseline (adaptation disabled)); liver: 65.8228% (minimum 99%, Baseline (adaptation disabled)); lung: 70.9091% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.3243% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.2277% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.2317% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 67.8261% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.7303% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.2222% (minimum 97%, Baseline (adaptation disabled)); retina: 67.8261% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 77.2277% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.6119% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.9048% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.2394% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.8290% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.9528% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.8571% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.4270% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.1878% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.1017% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.3,8,11.4,"adipose tissue: 11.4 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 2); salivary gland: 7.8 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); retina: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102595,UGGT2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.372222,-0.308983,-0.387683
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.7778% (minimum 95%, Missing); adrenal gland: 69.9552% (minimum 99%, Missing); amygdala: 78.3920% (minimum 99%, Missing); basal ganglia: 80.8290% (minimum 99%, Missing); bone marrow: 80.8290% (minimum 99%, Missing); cerebellum: 93.4132% (minimum 99%, Missing); cerebral cortex: 74.6411% (minimum 99%, Missing); choroid plexus: 69.3333% (minimum 99%, Missing); colon: 70.2703% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 80.4124% (minimum 97%, Missing); heart muscle: 65.0000% (minimum 99%, Missing); hippocampal formation: 74.2857% (minimum 99%, Missing); hypothalamus: 73.9336% (minimum 99%, Missing); kidney: 68.1223% (minimum 99%, Missing); liver: 65.8228% (minimum 99%, Missing); lung: 70.9091% (minimum 99%, Missing); lymph node: 84.3243% (minimum 97%, Missing); midbrain: 77.2277% (minimum 99%, Missing); pancreas: 60.2317% (minimum 99%, Missing); parathyroid gland: 67.8261% (minimum 97%, Missing); pituitary gland: 64.7303% (minimum 99%, Missing); rectum: 72.2222% (minimum 97%, Missing); retina: 67.8261% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 80.0000% (minimum 99%, Missing); skin: 77.2277% (minimum 95%, Missing); small intestine: 77.6119% (minimum 99%, Missing); smooth muscle: 61.9048% (minimum 99%, Missing); spinal cord: 73.2394% (minimum 99%, Missing); spleen: 80.8290% (minimum 95%, Missing); stomach: 66.9528% (minimum 97%, Missing); thymus: 92.8571% (minimum 95%, Missing); thyroid gland: 58.4270% (minimum 95%, Missing); tongue: 79.1878% (minimum 97%, Missing); urinary bladder: 66.1017% (minimum 97%, Missing)",0,80,unavailable,10.3,8,11.4,"adipose tissue: 11.4 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 2); salivary gland: 7.8 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); retina: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102595,UGGT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.372222,-0.308983,-0.387683
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,7.5,5.1,3.6,"lung: 7.5 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); kidney: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); heart muscle: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); small intestine: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000102780,DGKH,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.3846% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.9506% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.9277% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 47.5524% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.9506% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.5433% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.2727% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.4444% (minimum 99%, Baseline (adaptation disabled)); colon: 65.3846% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.9277% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.9630% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.1031% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.1609% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.0698% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 87.1795% (minimum 99%, Baseline (adaptation disabled)); lung: 47.5524% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.4045% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.1795% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.8919% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.1183% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 73.1183% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.1031% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.9277% (minimum 99%, Baseline (adaptation disabled)); skin: 68.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.3404% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.5514% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.3117% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.9524% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.1183% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.3404% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 73.9130% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.4045% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,7.5,5.1,3.6,"lung: 7.5 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); kidney: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); heart muscle: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); small intestine: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000102780,DGKH,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.296154,-0.398571,-0.514476
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.3846% (minimum 95%, Missing); adrenal gland: 83.9506% (minimum 99%, Missing); amygdala: 81.9277% (minimum 99%, Missing); basal ganglia: 47.5524% (minimum 99%, Missing); bone marrow: 83.9506% (minimum 99%, Missing); cerebellum: 53.5433% (minimum 99%, Missing); cerebral cortex: 77.2727% (minimum 99%, Missing); choroid plexus: 94.4444% (minimum 99%, Missing); colon: 65.3846% (minimum 97%, Missing); duodenum: 81.9277% (minimum 99%, Missing); esophagus: 62.9630% (minimum 97%, Missing); heart muscle: 70.1031% (minimum 99%, Missing); hippocampal formation: 78.1609% (minimum 99%, Missing); hypothalamus: 79.0698% (minimum 99%, Missing); kidney: 68.0000% (minimum 99%, Missing); liver: 87.1795% (minimum 99%, Missing); lung: 47.5524% (minimum 99%, Missing); lymph node: 76.4045% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 87.1795% (minimum 99%, Missing); parathyroid gland: 91.8919% (minimum 97%, Missing); pituitary gland: 73.1183% (minimum 99%, Missing); rectum: 68.0000% (minimum 97%, Missing); retina: 73.1183% (minimum 99%, Missing); salivary gland: 70.1031% (minimum 97%, Missing); skeletal muscle: 81.9277% (minimum 99%, Missing); skin: 68.0000% (minimum 95%, Missing); small intestine: 72.3404% (minimum 99%, Missing); smooth muscle: 63.5514% (minimum 99%, Missing); spinal cord: 88.3117% (minimum 99%, Missing); spleen: 80.9524% (minimum 95%, Missing); stomach: 73.1183% (minimum 97%, Missing); thymus: 72.3404% (minimum 95%, Missing); thyroid gland: 73.9130% (minimum 95%, Missing); tongue: 76.4045% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",0,2,partial,7.5,5.1,3.6,"lung: 7.5 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); kidney: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); heart muscle: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); small intestine: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000102780,DGKH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.296154,-0.398571,-0.514476
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,17.3,8.4,9,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); adipose tissue: 8.4 nTPM (manageable, limit 5); colon: 8.4 nTPM (protected, limit 2); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); bone marrow: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 2); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102781,KATNAL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.6294% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.5188% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.1245% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.4490% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.9398% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.6923% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.7852% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.9868% (minimum 99%, Baseline (adaptation disabled)); colon: 70.6294% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.9535% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.2946% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 53.8667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.5276% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.0992% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.8174% (minimum 99%, Baseline (adaptation disabled)); liver: 84.1667% (minimum 99%, Baseline (adaptation disabled)); lung: 80.8000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.9398% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.2946% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.8182% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.5830% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.4459% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.4711% (minimum 97%, Baseline (adaptation disabled)); retina: 72.6619% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.5830% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.4781% (minimum 99%, Baseline (adaptation disabled)); skin: 88.9868% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.2096% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.3815% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.7226% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.3248% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.2096% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.1781% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.4459% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.2264% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.8000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,17.3,8.4,9,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); adipose tissue: 8.4 nTPM (manageable, limit 5); colon: 8.4 nTPM (protected, limit 2); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); bone marrow: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 2); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102781,KATNAL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.258219,-0.263706,-0.451333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.6294% (minimum 95%, Missing); adrenal gland: 84.5188% (minimum 99%, Missing); amygdala: 81.1245% (minimum 99%, Missing); basal ganglia: 82.4490% (minimum 99%, Missing); bone marrow: 75.9398% (minimum 99%, Missing); cerebellum: 77.6923% (minimum 99%, Missing); cerebral cortex: 67.7852% (minimum 99%, Missing); choroid plexus: 88.9868% (minimum 99%, Missing); colon: 70.6294% (minimum 97%, Missing); duodenum: 93.9535% (minimum 99%, Missing); esophagus: 78.2946% (minimum 97%, Missing); heart muscle: 53.8667% (minimum 99%, Missing); hippocampal formation: 79.5276% (minimum 99%, Missing); hypothalamus: 77.0992% (minimum 99%, Missing); kidney: 83.8174% (minimum 99%, Missing); liver: 84.1667% (minimum 99%, Missing); lung: 80.8000% (minimum 99%, Missing); lymph node: 75.9398% (minimum 97%, Missing); midbrain: 78.2946% (minimum 99%, Missing); pancreas: 91.8182% (minimum 99%, Missing); parathyroid gland: 90.5830% (minimum 97%, Missing); pituitary gland: 87.4459% (minimum 99%, Missing); rectum: 83.4711% (minimum 97%, Missing); retina: 72.6619% (minimum 99%, Missing); salivary gland: 90.5830% (minimum 97%, Missing); skeletal muscle: 80.4781% (minimum 99%, Missing); skin: 88.9868% (minimum 95%, Missing); small intestine: 88.2096% (minimum 99%, Missing); smooth muscle: 58.3815% (minimum 99%, Missing); spinal cord: 73.7226% (minimum 99%, Missing); spleen: 86.3248% (minimum 95%, Missing); stomach: 88.2096% (minimum 97%, Missing); thymus: 69.1781% (minimum 95%, Missing); thyroid gland: 87.4459% (minimum 95%, Missing); tongue: 76.2264% (minimum 97%, Missing); urinary bladder: 80.8000% (minimum 97%, Missing)",0,80,unavailable,17.3,8.4,9,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); adipose tissue: 8.4 nTPM (manageable, limit 5); colon: 8.4 nTPM (protected, limit 2); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); bone marrow: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 2); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102781,KATNAL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.258219,-0.263706,-0.451333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,439.8,1.7,11.4,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102924,CBLN1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.1132% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.8750% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.3846% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.8252% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 6.5845% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.9315% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7918% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.1787% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.8750% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.5706% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.9752% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 45.3216% (minimum 99%, Baseline (adaptation disabled)); liver: 96.8750% (minimum 99%, Baseline (adaptation disabled)); midbrain: 63.6550% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.9881% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 88.3191% (minimum 99%, Baseline (adaptation disabled)); retina: 90.1163% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.1787% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.9752% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.8012% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.1671% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 93.3735% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.8012% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.6790% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,439.8,1.7,11.4,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102924,CBLN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.218868,-0.0219878,-0.924155
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.1132% (minimum 95%, Missing); adrenal gland: 96.8750% (minimum 99%, Missing); amygdala: 95.3846% (minimum 99%, Missing); basal ganglia: 88.8252% (minimum 99%, Missing); cerebellum: 6.5845% (minimum 99%, Missing); cerebral cortex: 84.9315% (minimum 99%, Missing); choroid plexus: 97.7918% (minimum 99%, Missing); duodenum: 97.1787% (minimum 99%, Missing); esophagus: 96.8750% (minimum 97%, Missing); heart muscle: 87.5706% (minimum 99%, Missing); hippocampal formation: 95.9752% (minimum 99%, Missing); hypothalamus: 45.3216% (minimum 99%, Missing); liver: 96.8750% (minimum 99%, Missing); midbrain: 63.6550% (minimum 99%, Missing); pancreas: 91.9881% (minimum 99%, Missing); pituitary gland: 88.3191% (minimum 99%, Missing); retina: 90.1163% (minimum 99%, Missing); skeletal muscle: 97.1787% (minimum 99%, Missing); small intestine: 95.9752% (minimum 99%, Missing); smooth muscle: 94.8012% (minimum 99%, Missing); spinal cord: 76.1671% (minimum 99%, Missing); thyroid gland: 93.3735% (minimum 95%, Missing); tongue: 94.8012% (minimum 97%, Missing); urinary bladder: 95.6790% (minimum 97%, Missing)",0,80,unavailable,439.8,1.7,11.4,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000102924,CBLN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.218868,-0.0219878,-0.924155
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,4.4,8.2,20.5,"thymus: 20.5 nTPM (manageable, limit 5); lymph node: 8.2 nTPM (protected, limit 2); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000102970,CCL17,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 57.5758% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 38.7755% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.3750% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 86.3636% (minimum 99%, Baseline (adaptation disabled)); lung: 30.1587% (minimum 99%, Baseline (adaptation disabled)); lymph node: 18.8119% (minimum 97%, Baseline (adaptation disabled)); pancreas: 82.6087% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.0000% (minimum 97%, Baseline (adaptation disabled)); rectum: 42.2222% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 43.1818% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 44.1860% (minimum 95%, Baseline (adaptation disabled)); small intestine: 34.5455% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 43.1818% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.3704% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.0769% (minimum 97%, Baseline (adaptation disabled)); thymus: 8.4821% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.3704% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.4762% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 36.5385% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,4.4,8.2,20.5,"thymus: 20.5 nTPM (manageable, limit 5); lymph node: 8.2 nTPM (protected, limit 2); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000102970,CCL17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.865179,-0.781881,-0.688413
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.3333% (minimum 95%, Uncertain); adrenal gland: 95.0000% (minimum 99%, Missing); amygdala: 95.0000% (minimum 99%, Missing); cerebellum: 95.0000% (minimum 99%, Missing); cerebral cortex: 95.0000% (minimum 99%, Missing); choroid plexus: 95.0000% (minimum 99%, Missing); colon: 57.5758% (minimum 97%, Missing); duodenum: 95.0000% (minimum 99%, Missing); esophagus: 38.7755% (minimum 97%, Uncertain); heart muscle: 59.3750% (minimum 99%, Missing); hippocampal formation: 95.0000% (minimum 99%, Missing); kidney: 76.0000% (minimum 99%, Missing); liver: 86.3636% (minimum 99%, Missing); lung: 30.1587% (minimum 99%, Missing); lymph node: 18.8119% (minimum 97%, Missing); pancreas: 82.6087% (minimum 99%, Missing); parathyroid gland: 95.0000% (minimum 97%, Missing); rectum: 42.2222% (minimum 97%, Missing); salivary gland: 43.1818% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); skin: 44.1860% (minimum 95%, Missing); small intestine: 34.5455% (minimum 99%, Missing); smooth muscle: 43.1818% (minimum 99%, Missing); spinal cord: 95.0000% (minimum 99%, Missing); spleen: 70.3704% (minimum 95%, Uncertain); stomach: 73.0769% (minimum 97%, Missing); thymus: 8.4821% (minimum 95%, Missing); thyroid gland: 70.3704% (minimum 95%, Missing); tongue: 90.4762% (minimum 97%, Missing); urinary bladder: 36.5385% (minimum 97%, Missing)",0,3,partial,4.4,8.2,20.5,"thymus: 20.5 nTPM (manageable, limit 5); lymph node: 8.2 nTPM (protected, limit 2); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000102970,CCL17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.865179,-0.781881,-0.688413
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.3,6.6,2.4,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000103021,CFAP263,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.6380% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.3575% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.8428% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.4985% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.5137% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.4557% (minimum 99%, Baseline (adaptation disabled)); colon: 96.4856% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.6928% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.5696% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.4192% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.9670% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.1226% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.6708% (minimum 99%, Baseline (adaptation disabled)); liver: 96.7949% (minimum 99%, Baseline (adaptation disabled)); lung: 89.6142% (minimum 99%, Baseline (adaptation disabled)); midbrain: 87.2832% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.8730% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.0652% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.6907% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.9686% (minimum 97%, Baseline (adaptation disabled)); retina: 76.8448% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.7949% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.0732% (minimum 99%, Baseline (adaptation disabled)); skin: 92.6380% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.6928% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.5696% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.8810% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.5696% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.2099% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.9231% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.8730% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.3,6.6,2.4,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000103021,CFAP263,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0236196,-0.149348,-0.225443
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.6380% (minimum 99%, Missing); amygdala: 84.3575% (minimum 99%, Missing); basal ganglia: 81.8428% (minimum 99%, Missing); cerebellum: 93.4985% (minimum 99%, Missing); cerebral cortex: 82.5137% (minimum 99%, Missing); choroid plexus: 76.4557% (minimum 99%, Missing); colon: 96.4856% (minimum 97%, Missing); duodenum: 98.6928% (minimum 99%, Missing); esophagus: 95.5696% (minimum 97%, Missing); heart muscle: 90.4192% (minimum 99%, Missing); hippocampal formation: 82.9670% (minimum 99%, Missing); hypothalamus: 84.1226% (minimum 99%, Missing); kidney: 94.6708% (minimum 99%, Missing); liver: 96.7949% (minimum 99%, Missing); lung: 89.6142% (minimum 99%, Missing); midbrain: 87.2832% (minimum 99%, Missing); pancreas: 95.8730% (minimum 99%, Missing); parathyroid gland: 82.0652% (minimum 97%, Missing); pituitary gland: 90.6907% (minimum 99%, Missing); rectum: 94.9686% (minimum 97%, Missing); retina: 76.8448% (minimum 99%, Missing); salivary gland: 96.7949% (minimum 97%, Missing); skeletal muscle: 92.0732% (minimum 99%, Missing); skin: 92.6380% (minimum 95%, Missing); small intestine: 98.6928% (minimum 99%, Missing); smooth muscle: 95.5696% (minimum 99%, Missing); spinal cord: 89.8810% (minimum 99%, Missing); stomach: 95.5696% (minimum 97%, Missing); thyroid gland: 93.2099% (minimum 95%, Missing); tongue: 92.9231% (minimum 97%, Missing); urinary bladder: 95.8730% (minimum 97%, Missing)",0,80,unavailable,9.3,6.6,2.4,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000103021,CFAP263,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0236196,-0.149348,-0.225443
True,compatible,,True,True,False,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000103023,PRSS54,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000103023,PRSS54,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00751861
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000103023,PRSS54,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00751861
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,10,13.6,9.3,"parathyroid gland: 13.6 nTPM (protected, limit 2); tongue: 10.2 nTPM (protected, limit 2); colon: 10.1 nTPM (protected, limit 2); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 2); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 4); salivary gland: 7.7 nTPM (protected, limit 2); thyroid gland: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); rectum: 6.9 nTPM (protected, limit 2); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); basal ganglia: 6.6 nTPM (vital, limit 1); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 2); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 2); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 2); pancreas: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000103343,ZNF174,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6872% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.6374% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.1429% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 63.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 74.0260% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.4356% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.9626% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.5172% (minimum 99%, Baseline (adaptation disabled)); colon: 53.0233% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.5172% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.8960% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.0284% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.6374% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.0449% (minimum 99%, Baseline (adaptation disabled)); liver: 63.6872% (minimum 99%, Baseline (adaptation disabled)); lung: 68.6747% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.7629% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 45.6000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.8824% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.2951% (minimum 97%, Baseline (adaptation disabled)); retina: 54.2857% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.6859% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 54.5455% (minimum 99%, Baseline (adaptation disabled)); skin: 61.2903% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.4068% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.2710% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 58.4615% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.6216% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.0725% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.9626% (minimum 95%, Baseline (adaptation disabled)); tongue: 52.7778% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.7164% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,10,13.6,9.3,"parathyroid gland: 13.6 nTPM (protected, limit 2); tongue: 10.2 nTPM (protected, limit 2); colon: 10.1 nTPM (protected, limit 2); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 2); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 2); salivary gland: 7.7 nTPM (protected, limit 2); cerebral cortex: 7.3 nTPM (vital, limit 1); thyroid gland: 7.3 nTPM (manageable, limit 5); skin: 7.2 nTPM (manageable, limit 5); spleen: 7.1 nTPM (manageable, limit 5); rectum: 6.9 nTPM (protected, limit 2); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); midbrain: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 2); pancreas: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000103343,ZNF174,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.399275,-0.514,-0.45729
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6872% (minimum 95%, Missing); adrenal gland: 62.6374% (minimum 99%, Missing); amygdala: 65.1429% (minimum 99%, Missing); basal ganglia: 63.3333% (minimum 99%, Missing); bone marrow: 74.0260% (minimum 99%, Missing); cerebellum: 56.4356% (minimum 99%, Missing); cerebral cortex: 60.9626% (minimum 99%, Missing); choroid plexus: 65.5172% (minimum 99%, Missing); colon: 53.0233% (minimum 97%, Missing); duodenum: 65.5172% (minimum 98%, Approved); esophagus: 65.8960% (minimum 97%, Missing); heart muscle: 54.0284% (minimum 99%, Missing); hippocampal formation: 63.3333% (minimum 99%, Missing); hypothalamus: 62.6374% (minimum 99%, Missing); kidney: 64.0449% (minimum 99%, Missing); liver: 63.6872% (minimum 99%, Missing); lung: 68.6747% (minimum 99%, Missing); lymph node: 58.7629% (minimum 95%, Approved); midbrain: 63.3333% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 45.6000% (minimum 97%, Missing); pituitary gland: 55.8824% (minimum 99%, Missing); rectum: 62.2951% (minimum 97%, Missing); retina: 54.2857% (minimum 99%, Missing); salivary gland: 59.6859% (minimum 97%, Missing); skeletal muscle: 54.5455% (minimum 99%, Missing); skin: 61.2903% (minimum 95%, Missing); small intestine: 64.4068% (minimum 98%, Approved); smooth muscle: 53.2710% (minimum 99%, Missing); spinal cord: 58.4615% (minimum 99%, Missing); spleen: 61.6216% (minimum 90%, Approved); stomach: 63.3333% (minimum 97%, Missing); thymus: 55.0725% (minimum 95%, Missing); thyroid gland: 60.9626% (minimum 95%, Missing); tongue: 52.7778% (minimum 97%, Missing); urinary bladder: 56.7164% (minimum 97%, Missing)",0,2,partial,10,13.6,9.3,"parathyroid gland: 13.6 nTPM (protected, limit 2); tongue: 10.2 nTPM (protected, limit 2); colon: 10.1 nTPM (protected, limit 2); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 2); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 4); salivary gland: 7.7 nTPM (protected, limit 2); thyroid gland: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); rectum: 6.9 nTPM (protected, limit 2); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); basal ganglia: 6.6 nTPM (vital, limit 1); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 2); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 2); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 2); pancreas: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000103343,ZNF174,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.399275,-0.514,-0.45729
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,10.1,1.1,4.5,"adrenal gland: 10.1 nTPM (vital, limit 6)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000103546,SLC6A2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.4110% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 39.5210% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5075% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.0588% (minimum 99%, Baseline (adaptation disabled)); liver: 97.0588% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.6522% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 85.7143% (minimum 97%, Baseline (adaptation disabled)); skin: 59.4595% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.5075% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.6522% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,10.1,1.1,4.5,"adrenal gland: 10.1 nTPM (vital, limit 1)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000103546,SLC6A2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,-0.355405,-0.112857,-0.59479
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 39.5210% (minimum 95%, Enhanced); amygdala: 98.5075% (minimum 99%, Missing); skin: 59.4595% (minimum 60%, Enhanced)",0,4,partial,10.1,1.1,4.5,"adrenal gland: 10.1 nTPM (vital, limit 6)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000103546,SLC6A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,-0.00540541,0.03,-0.55479
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.8,3.6,3.9,"retina: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000103599,IQCH,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.0569% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7265% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2456% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 96.5517% (minimum 97%, Baseline (adaptation disabled)); esophagus: 95.7265% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.5620% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.1176% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.0569% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.2105% (minimum 99%, Baseline (adaptation disabled)); liver: 92.5620% (minimum 99%, Baseline (adaptation disabled)); lung: 92.5620% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.7265% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.1176% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.6757% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.8485% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.1176% (minimum 97%, Baseline (adaptation disabled)); retina: 70.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.9153% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.7265% (minimum 99%, Baseline (adaptation disabled)); skin: 94.9153% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 98.2456% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.7265% (minimum 99%, Baseline (adaptation disabled)); stomach: 91.0569% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.8033% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 74.1722% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.1176% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.8,3.6,3.9,"retina: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000103599,IQCH,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.208278,-0.213243,-0.29
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.0569% (minimum 99%, Missing); amygdala: 95.7265% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); cerebellum: 98.2456% (minimum 99%, Missing); cerebral cortex: 93.3333% (minimum 99%, Missing); choroid plexus: 87.5000% (minimum 99%, Missing); colon: 96.5517% (minimum 97%, Missing); esophagus: 95.7265% (minimum 97%, Missing); heart muscle: 92.5620% (minimum 99%, Missing); hippocampal formation: 94.1176% (minimum 99%, Missing); hypothalamus: 91.0569% (minimum 99%, Missing); kidney: 84.2105% (minimum 99%, Missing); liver: 92.5620% (minimum 99%, Missing); lung: 92.5620% (minimum 99%, Missing); midbrain: 95.7265% (minimum 99%, Missing); pancreas: 94.1176% (minimum 99%, Missing); parathyroid gland: 75.6757% (minimum 97%, Missing); pituitary gland: 84.8485% (minimum 99%, Missing); rectum: 94.1176% (minimum 97%, Missing); retina: 70.0000% (minimum 99%, Missing); salivary gland: 94.9153% (minimum 97%, Missing); skeletal muscle: 95.7265% (minimum 99%, Missing); skin: 94.9153% (minimum 95%, Missing); smooth muscle: 98.2456% (minimum 99%, Missing); spinal cord: 95.7265% (minimum 99%, Missing); stomach: 91.0569% (minimum 97%, Missing); thymus: 91.8033% (minimum 95%, Missing); thyroid gland: 74.1722% (minimum 95%, Missing); urinary bladder: 94.1176% (minimum 97%, Missing)",0,80,unavailable,4.8,3.6,3.9,"retina: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000103599,IQCH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.208278,-0.213243,-0.29
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,9,partial,56.5,34.9,17.8,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 2); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); lymph node: 19.3 nTPM (protected, limit 2); urinary bladder: 19 nTPM (protected, limit 2); duodenum: 19 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 2); spleen: 17.8 nTPM (manageable, limit 5); adipose tissue: 16.7 nTPM (manageable, limit 15); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 2); esophagus: 14.4 nTPM (protected, limit 2); stomach: 12.4 nTPM (protected, limit 2); choroid plexus: 12 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); parathyroid gland: 9.5 nTPM (protected, limit 2); thyroid gland: 9 nTPM (manageable, limit 5); thymus: 8.9 nTPM (manageable, limit 5); smooth muscle: 8.7 nTPM (vital, limit 3); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000103642,LACTB,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1680% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 46.5217% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0877% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.5424% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 27.4711% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.7547% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.4286% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.0719% (minimum 99%, Baseline (adaptation disabled)); colon: 54.4529% (minimum 97%, Baseline (adaptation disabled)); duodenum: 52.9703% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.7765% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 49.8834% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.7025% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.1566% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.5261% (minimum 99%, Baseline (adaptation disabled)); liver: 34.2400% (minimum 99%, Baseline (adaptation disabled)); lung: 53.7688% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.5799% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.3056% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.5079% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.2557% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.7025% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.1522% (minimum 97%, Baseline (adaptation disabled)); retina: 82.6255% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.0323% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 31.0595% (minimum 99%, Baseline (adaptation disabled)); skin: 64.8485% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.6138% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.0963% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.4286% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.5918% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.3136% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.6271% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.3947% (minimum 95%, Baseline (adaptation disabled)); tongue: 38.0107% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.9703% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,56.5,34.9,17.8,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 2); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); lymph node: 19.3 nTPM (protected, limit 2); urinary bladder: 19 nTPM (protected, limit 2); duodenum: 19 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 2); spleen: 17.8 nTPM (manageable, limit 5); adipose tissue: 16.7 nTPM (manageable, limit 5); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 2); esophagus: 14.4 nTPM (protected, limit 2); stomach: 12.4 nTPM (protected, limit 2); choroid plexus: 12 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); parathyroid gland: 9.5 nTPM (protected, limit 2); thyroid gland: 9 nTPM (manageable, limit 5); thymus: 8.9 nTPM (manageable, limit 5); smooth muscle: 8.7 nTPM (vital, limit 1); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000103642,LACTB,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.404082,-0.589893,-0.715289
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1680% (minimum 80%, Supported); adrenal gland: 46.5217% (minimum 99%, Missing); amygdala: 75.0877% (minimum 99%, Missing); basal ganglia: 72.5424% (minimum 99%, Missing); bone marrow: 27.4711% (minimum 99%, Missing); cerebellum: 80.7547% (minimum 99%, Missing); cerebral cortex: 76.4286% (minimum 99%, Missing); choroid plexus: 64.0719% (minimum 99%, Missing); colon: 54.4529% (minimum 97%, Missing); duodenum: 52.9703% (minimum 99%, Missing); esophagus: 59.7765% (minimum 97%, Missing); heart muscle: 49.8834% (minimum 99%, Missing); hippocampal formation: 76.7025% (minimum 99%, Missing); hypothalamus: 76.1566% (minimum 99%, Missing); kidney: 48.5261% (minimum 99%, Missing); liver: 34.2400% (minimum 99%, Missing); lung: 53.7688% (minimum 99%, Missing); lymph node: 52.5799% (minimum 97%, Missing); midbrain: 74.3056% (minimum 99%, Missing); pancreas: 67.5079% (minimum 99%, Missing); parathyroid gland: 69.2557% (minimum 97%, Missing); pituitary gland: 76.7025% (minimum 99%, Missing); rectum: 58.1522% (minimum 97%, Missing); retina: 82.6255% (minimum 99%, Missing); salivary gland: 69.0323% (minimum 97%, Missing); skeletal muscle: 31.0595% (minimum 99%, Missing); skin: 64.8485% (minimum 95%, Missing); small intestine: 56.6138% (minimum 99%, Missing); smooth muscle: 71.0963% (minimum 97%, Supported); spinal cord: 76.4286% (minimum 99%, Missing); spleen: 54.5918% (minimum 95%, Missing); stomach: 63.3136% (minimum 97%, Missing); thymus: 70.6271% (minimum 95%, Missing); thyroid gland: 70.3947% (minimum 95%, Missing); tongue: 38.0107% (minimum 97%, Missing); urinary bladder: 52.9703% (minimum 97%, Missing)",0,9,partial,56.5,34.9,17.8,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 2); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); lymph node: 19.3 nTPM (protected, limit 2); urinary bladder: 19 nTPM (protected, limit 2); duodenum: 19 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 2); spleen: 17.8 nTPM (manageable, limit 5); adipose tissue: 16.7 nTPM (manageable, limit 15); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 2); esophagus: 14.4 nTPM (protected, limit 2); stomach: 12.4 nTPM (protected, limit 2); choroid plexus: 12 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); parathyroid gland: 9.5 nTPM (protected, limit 2); thyroid gland: 9 nTPM (manageable, limit 5); thymus: 8.9 nTPM (manageable, limit 5); smooth muscle: 8.7 nTPM (vital, limit 3); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000103642,LACTB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.404082,-0.589893,-0.715289
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,12,partial,44.6,12.3,1.9,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000103723,AP3B2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.9091% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.2524% (minimum 99%, Baseline (adaptation disabled)); amygdala: 44.4444% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 36.8098% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.2353% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 11.8577% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 17.8571% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 56.0748% (minimum 99%, Baseline (adaptation disabled)); colon: 85.7143% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.5522% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.9091% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.7742% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 40.8163% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 31.9149% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.9091% (minimum 99%, Baseline (adaptation disabled)); liver: 96.7742% (minimum 99%, Baseline (adaptation disabled)); lung: 95.2381% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.7500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 50.8475% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 32.7869% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 24.6914% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.3077% (minimum 97%, Baseline (adaptation disabled)); retina: 15.8730% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.2353% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); skin: 86.9565% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.2353% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.6038% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.5522% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.7143% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.9565% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.9494% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.2381% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.5522% (minimum 97%, Baseline (adaptation disabled))",0,12,partial,44.6,12.3,1.9,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000103723,AP3B2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.190506,-0.642131,-0.871423
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.2524% (minimum 99%, Missing); amygdala: 44.4444% (minimum 99%, Missing); basal ganglia: 36.8098% (minimum 99%, Missing); bone marrow: 88.2353% (minimum 95%, Enhanced); cerebellum: 11.8577% (minimum 99%, Missing); cerebral cortex: 17.8571% (minimum 99%, Missing); choroid plexus: 56.0748% (minimum 99%, Missing); colon: 85.7143% (minimum 97%, Missing); duodenum: 89.5522% (minimum 99%, Missing); hippocampal formation: 40.8163% (minimum 99%, Missing); hypothalamus: 31.9149% (minimum 99%, Missing); kidney: 90.9091% (minimum 95%, Enhanced); midbrain: 50.8475% (minimum 99%, Missing); pancreas: 75.0000% (minimum 95%, Enhanced); parathyroid gland: 32.7869% (minimum 97%, Missing); pituitary gland: 24.6914% (minimum 99%, Missing); rectum: 92.3077% (minimum 97%, Missing); retina: 15.8730% (minimum 99%, Missing); small intestine: 88.2353% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 95%, Enhanced); spinal cord: 56.6038% (minimum 99%, Missing); thymus: 86.9565% (minimum 95%, Missing); thyroid gland: 75.9494% (minimum 95%, Missing); tongue: 95.2381% (minimum 97%, Missing)",0,12,partial,44.6,12.3,1.9,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000103723,AP3B2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.190506,-0.642131,-0.871423
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,16.2,4.2,5.5,"bone marrow: 16.2 nTPM (vital, limit 2); thymus: 5.5 nTPM (manageable, limit 5); lymph node: 4.2 nTPM (protected, limit 4); rectum: 3 nTPM (protected, limit 2); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 2); kidney: 2.1 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 2); retina: 1.8 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000103995,CEP152,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.3559% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.0734% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.1176% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.4286% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 37.2093% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.7196% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.3077% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.7196% (minimum 99%, Baseline (adaptation disabled)); colon: 81.3559% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.4194% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.3388% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.0513% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.1176% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.0513% (minimum 99%, Baseline (adaptation disabled)); liver: 90.5660% (minimum 99%, Baseline (adaptation disabled)); lung: 82.0513% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.5652% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.2039% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.8000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.0734% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.4286% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.1905% (minimum 97%, Baseline (adaptation disabled)); retina: 84.2105% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.6723% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.5660% (minimum 99%, Baseline (adaptation disabled)); skin: 76.8000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.8000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.4783% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.3077% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.3559% (minimum 97%, Baseline (adaptation disabled)); thymus: 63.5762% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 77.4194% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.1176% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.0734% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,16.2,4.2,5.5,"bone marrow: 16.2 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); lymph node: 4.2 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000103995,CEP152,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.314238,-0.274348,-0.617907
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.3559% (minimum 90%, Approved); adrenal gland: 88.0734% (minimum 98%, Approved); amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 91.4286% (minimum 99%, Missing); bone marrow: 37.2093% (minimum 98%, Approved); cerebellum: 89.7196% (minimum 99%, Missing); cerebral cortex: 92.3077% (minimum 99%, Missing); choroid plexus: 89.7196% (minimum 99%, Missing); colon: 81.3559% (minimum 97%, Missing); duodenum: 77.4194% (minimum 99%, Missing); esophagus: 79.3388% (minimum 95%, Approved); heart muscle: 82.0513% (minimum 98%, Approved); hippocampal formation: 94.1176% (minimum 99%, Missing); hypothalamus: 96.0000% (minimum 99%, Missing); kidney: 82.0513% (minimum 98%, Approved); liver: 90.5660% (minimum 98%, Approved); lung: 82.0513% (minimum 98%, Approved); lymph node: 69.5652% (minimum 95%, Approved); midbrain: 93.2039% (minimum 99%, Missing); pancreas: 76.8000% (minimum 99%, Missing); parathyroid gland: 88.0734% (minimum 95%, Approved); pituitary gland: 91.4286% (minimum 99%, Missing); rectum: 76.1905% (minimum 97%, Missing); retina: 84.2105% (minimum 99%, Missing); salivary gland: 80.6723% (minimum 97%, Missing); skeletal muscle: 90.5660% (minimum 98%, Approved); skin: 76.8000% (minimum 95%, Missing); small intestine: 76.8000% (minimum 99%, Missing); smooth muscle: 83.4783% (minimum 98%, Approved); spinal cord: 92.3077% (minimum 99%, Missing); spleen: 80.0000% (minimum 90%, Approved); stomach: 81.3559% (minimum 97%, Missing); thymus: 63.5762% (minimum 95%, Missing); thyroid gland: 77.4194% (minimum 90%, Approved); tongue: 94.1176% (minimum 97%, Missing); urinary bladder: 88.0734% (minimum 97%, Missing)",0,3,partial,16.2,4.2,5.5,"bone marrow: 16.2 nTPM (vital, limit 2); thymus: 5.5 nTPM (manageable, limit 5); lymph node: 4.2 nTPM (protected, limit 4); rectum: 3 nTPM (protected, limit 2); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 2); kidney: 2.1 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 2); retina: 1.8 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000103995,CEP152,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.314238,-0.254348,-0.607907
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,10.2,5.6,8.8,"bone marrow: 10.2 nTPM (vital, limit 6); skeletal muscle: 9.9 nTPM (vital, limit 6); thymus: 8.8 nTPM (manageable, limit 5)",pancreas / exocrine glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000104147,OIP5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.6941% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5437% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5437% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.5574% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.5437% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.5962% (minimum 99%, Baseline (adaptation disabled)); colon: 83.5391% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.6540% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.5833% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.5484% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5437% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.5437% (minimum 99%, Baseline (adaptation disabled)); liver: 94.4186% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5962% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.3784% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.5437% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.5437% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.2324% (minimum 97%, Baseline (adaptation disabled)); retina: 96.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.2085% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 67.2185% (minimum 99%, Baseline (adaptation disabled)); skin: 86.3830% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.2324% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.3052% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.5962% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.2727% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.1193% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.7595% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.6667% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,10.2,5.6,8.8,"bone marrow: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); small intestine: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000104147,OIP5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.252405,-0.186216,-0.324426
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.6941% (minimum 95%, Enhanced); amygdala: 98.5437% (minimum 99%, Missing); basal ganglia: 98.5437% (minimum 99%, Missing); bone marrow: 66.5574% (minimum 95%, Enhanced); duodenum: 85.6540% (minimum 95%, Enhanced); heart muscle: 93.5484% (minimum 95%, Enhanced); hippocampal formation: 98.5437% (minimum 99%, Missing); liver: 94.4186% (minimum 95%, Enhanced); lymph node: 78.3784% (minimum 80%, Enhanced); midbrain: 98.5437% (minimum 99%, Missing); pancreas: 98.5437% (minimum 99%, Missing); retina: 96.6667% (minimum 99%, Missing); skeletal muscle: 67.2185% (minimum 95%, Enhanced); small intestine: 84.2324% (minimum 95%, Enhanced); spinal cord: 97.5962% (minimum 99%, Missing); thymus: 69.7595% (minimum 95%, Missing); tongue: 96.6667% (minimum 97%, Missing)",0,3,partial,10.2,5.6,8.8,"bone marrow: 10.2 nTPM (vital, limit 6); skeletal muscle: 9.9 nTPM (vital, limit 6); thymus: 8.8 nTPM (manageable, limit 5)",pancreas / exocrine glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000104147,OIP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.252405,-0.0162162,-0.284426
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,13.1,4.2,4.5,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); parathyroid gland: 4.1 nTPM (protected, limit 2); cerebral cortex: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); small intestine: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); tongue: 2.7 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000104218,CSPP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.2195% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.6993% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.7576% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.4286% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.5926% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.1026% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.7576% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.6871% (minimum 99%, Baseline (adaptation disabled)); colon: 75.7576% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.0340% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.1139% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.6398% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.2543% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.4286% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.2247% (minimum 99%, Baseline (adaptation disabled)); liver: 70.2247% (minimum 99%, Baseline (adaptation disabled)); lung: 69.0608% (minimum 99%, Baseline (adaptation disabled)); lymph node: 89.2857% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.6398% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.3060% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.3012% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 79.6178% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.2368% (minimum 97%, Baseline (adaptation disabled)); retina: 85.0340% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.1250% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 48.8281% (minimum 99%, Baseline (adaptation disabled)); skin: 78.1250% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.6871% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.4048% (minimum 99%, Baseline (adaptation disabled)); spleen: 79.1139% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.8503% (minimum 97%, Baseline (adaptation disabled)); thymus: 76.6871% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 73.5294% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.2368% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.2195% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,13.1,4.2,4.5,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); parathyroid gland: 4.1 nTPM (protected, limit 2); cerebral cortex: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); small intestine: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); tongue: 2.7 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000104218,CSPP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.214706,-0.221497,-0.501719
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.2195% (minimum 95%, Missing); adrenal gland: 81.6993% (minimum 99%, Missing); amygdala: 75.7576% (minimum 99%, Missing); basal ganglia: 71.4286% (minimum 99%, Missing); bone marrow: 92.5926% (minimum 99%, Missing); cerebellum: 64.1026% (minimum 99%, Missing); cerebral cortex: 75.7576% (minimum 99%, Missing); choroid plexus: 76.6871% (minimum 99%, Missing); colon: 75.7576% (minimum 97%, Missing); duodenum: 85.0340% (minimum 99%, Missing); esophagus: 79.1139% (minimum 97%, Missing); heart muscle: 77.6398% (minimum 99%, Missing); hippocampal formation: 72.2543% (minimum 99%, Missing); hypothalamus: 71.4286% (minimum 99%, Missing); kidney: 70.2247% (minimum 99%, Missing); liver: 70.2247% (minimum 99%, Missing); lung: 69.0608% (minimum 99%, Missing); lymph node: 89.2857% (minimum 97%, Missing); midbrain: 77.6398% (minimum 99%, Missing); pancreas: 68.3060% (minimum 99%, Missing); parathyroid gland: 75.3012% (minimum 97%, Missing); pituitary gland: 79.6178% (minimum 99%, Missing); rectum: 82.2368% (minimum 97%, Missing); retina: 85.0340% (minimum 99%, Missing); salivary gland: 78.1250% (minimum 97%, Missing); skeletal muscle: 48.8281% (minimum 99%, Missing); skin: 78.1250% (minimum 95%, Missing); small intestine: 76.6871% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spinal cord: 74.4048% (minimum 99%, Missing); spleen: 79.1139% (minimum 95%, Missing); stomach: 74.8503% (minimum 97%, Missing); thymus: 76.6871% (minimum 95%, Missing); thyroid gland: 73.5294% (minimum 95%, Missing); tongue: 82.2368% (minimum 97%, Missing); urinary bladder: 76.2195% (minimum 97%, Missing)",0,80,unavailable,13.1,4.2,4.5,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); parathyroid gland: 4.1 nTPM (protected, limit 2); cerebral cortex: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); small intestine: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); tongue: 2.7 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000104218,CSPP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.214706,-0.221497,-0.501719
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,8.5,8.5,8.5,"lymph node: 8.5 nTPM (protected, limit 4); small intestine: 8.5 nTPM (vital, limit 2); duodenum: 6.5 nTPM (vital, limit 2); colon: 4.9 nTPM (protected, limit 4); rectum: 4.3 nTPM (protected, limit 4); liver: 4 nTPM (vital, limit 2); lung: 3.2 nTPM (vital, limit 2); bone marrow: 2.1 nTPM (vital, limit 2)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000104432,IL7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 67.6471% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.7018% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.8333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.8333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.6567% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.1852% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.8776% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.8333% (minimum 99%, Baseline (adaptation disabled)); colon: 48.4211% (minimum 97%, Baseline (adaptation disabled)); duodenum: 41.4414% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.1961% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.8333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.8776% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 53.4884% (minimum 99%, Baseline (adaptation disabled)); lung: 58.9744% (minimum 99%, Baseline (adaptation disabled)); lymph node: 35.1145% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.8333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.1429% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.1961% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.6854% (minimum 97%, Baseline (adaptation disabled)); retina: 86.7925% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.7018% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.8723% (minimum 99%, Baseline (adaptation disabled)); skin: 35.1145% (minimum 95%, Baseline (adaptation disabled)); small intestine: 35.1145% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.7018% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.8333% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.4217% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.1852% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 79.3103% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 63.0137% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,8.5,8.5,8.5,"lymph node: 8.5 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.5 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 2); rectum: 4.3 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000104432,IL7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.598855,-0.618855,-0.638855
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 67.6471% (minimum 90%, Approved); adrenal gland: 80.7018% (minimum 98%, Approved); amygdala: 95.8333% (minimum 99%, Missing); basal ganglia: 95.8333% (minimum 99%, Missing); bone marrow: 68.6567% (minimum 98%, Approved); cerebellum: 85.1852% (minimum 98%, Approved); cerebral cortex: 93.8776% (minimum 98%, Approved); choroid plexus: 95.8333% (minimum 99%, Missing); colon: 48.4211% (minimum 95%, Approved); duodenum: 41.4414% (minimum 98%, Approved); esophagus: 57.5000% (minimum 95%, Approved); heart muscle: 90.1961% (minimum 98%, Approved); hippocampal formation: 95.8333% (minimum 99%, Missing); hypothalamus: 93.8776% (minimum 99%, Missing); kidney: 76.6667% (minimum 98%, Approved); liver: 53.4884% (minimum 98%, Approved); lung: 58.9744% (minimum 98%, Approved); lymph node: 35.1145% (minimum 95%, Approved); midbrain: 95.8333% (minimum 99%, Missing); pancreas: 82.1429% (minimum 98%, Approved); pituitary gland: 90.1961% (minimum 99%, Missing); rectum: 51.6854% (minimum 95%, Approved); retina: 86.7925% (minimum 99%, Missing); salivary gland: 80.7018% (minimum 95%, Approved); skeletal muscle: 97.8723% (minimum 98%, Approved); skin: 35.1145% (minimum 90%, Approved); small intestine: 35.1145% (minimum 98%, Approved); smooth muscle: 80.7018% (minimum 98%, Approved); spinal cord: 95.8333% (minimum 99%, Missing); spleen: 57.5000% (minimum 90%, Approved); stomach: 55.4217% (minimum 95%, Approved); thymus: 85.1852% (minimum 95%, Missing); thyroid gland: 79.3103% (minimum 90%, Approved); urinary bladder: 63.0137% (minimum 95%, Approved)",0,6,partial,8.5,8.5,8.5,"lymph node: 8.5 nTPM (protected, limit 4); small intestine: 8.5 nTPM (vital, limit 2); duodenum: 6.5 nTPM (vital, limit 2); colon: 4.9 nTPM (protected, limit 4); rectum: 4.3 nTPM (protected, limit 4); liver: 4 nTPM (vital, limit 2); lung: 3.2 nTPM (vital, limit 2); bone marrow: 2.1 nTPM (vital, limit 2)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000104432,IL7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.548855,-0.598855,-0.628855
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,10.6,17.7,7.7,"rectum: 17.7 nTPM (protected, limit 2); colon: 12.4 nTPM (protected, limit 12); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000104450,SPAG1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.7476% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.5644% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.3178% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.6283% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.3979% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.1739% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.9070% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.0678% (minimum 99%, Baseline (adaptation disabled)); colon: 60.3834% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.0968% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.3208% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.1034% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.9091% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.1739% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.9091% (minimum 99%, Baseline (adaptation disabled)); liver: 80.4255% (minimum 99%, Baseline (adaptation disabled)); lung: 79.4118% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.0968% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.7324% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.4783% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.4590% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.6393% (minimum 97%, Baseline (adaptation disabled)); retina: 91.3043% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 81.1159% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.9275% (minimum 99%, Baseline (adaptation disabled)); skin: 71.0526% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.9070% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.3043% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.7324% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.8654% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.2988% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.4306% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.1351% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 78.7500% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,10.6,17.7,7.7,"rectum: 17.7 nTPM (protected, limit 2); colon: 12.4 nTPM (protected, limit 2); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); parathyroid gland: 8.7 nTPM (protected, limit 2); skin: 7.7 nTPM (manageable, limit 5); esophagus: 7.6 nTPM (protected, limit 2); stomach: 6.2 nTPM (protected, limit 2); pituitary gland: 5.5 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); liver: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); hypothalamus: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000104450,SPAG1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.239474,-0.453607,-0.349322
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.5644% (minimum 95%, Enhanced); amygdala: 88.3178% (minimum 99%, Missing); basal ganglia: 83.6283% (minimum 99%, Missing); bone marrow: 65.3979% (minimum 99%, Missing); cerebellum: 82.1739% (minimum 95%, Enhanced); cerebral cortex: 87.9070% (minimum 95%, Enhanced); choroid plexus: 64.0678% (minimum 99%, Missing); colon: 60.3834% (minimum 80%, Enhanced); duodenum: 87.0968% (minimum 95%, Enhanced); esophagus: 71.3208% (minimum 80%, Enhanced); heart muscle: 93.1034% (minimum 95%, Enhanced); hippocampal formation: 85.9091% (minimum 99%, Missing); hypothalamus: 82.1739% (minimum 99%, Missing); kidney: 85.9091% (minimum 95%, Enhanced); liver: 80.4255% (minimum 95%, Enhanced); lung: 79.4118% (minimum 95%, Enhanced); midbrain: 87.0968% (minimum 99%, Missing); pancreas: 88.7324% (minimum 95%, Enhanced); parathyroid gland: 68.4783% (minimum 80%, Enhanced); pituitary gland: 77.4590% (minimum 99%, Missing); rectum: 51.6393% (minimum 97%, Missing); retina: 91.3043% (minimum 99%, Missing); skeletal muscle: 97.9275% (minimum 99%, Missing); small intestine: 87.9070% (minimum 99%, Missing); smooth muscle: 91.3043% (minimum 99%, Missing); spinal cord: 88.7324% (minimum 99%, Missing); stomach: 75.2988% (minimum 80%, Enhanced); thymus: 90.4306% (minimum 95%, Missing); urinary bladder: 78.7500% (minimum 80%, Enhanced)",0,5,partial,10.6,17.7,7.7,"rectum: 17.7 nTPM (protected, limit 2); colon: 12.4 nTPM (protected, limit 12); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000104450,SPAG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0456938,-0.453607,-0.349322
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,11.4,16.2,11.7,"esophagus: 16.2 nTPM (protected, limit 2); spleen: 11.7 nTPM (manageable, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); bone marrow: 10.4 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); tongue: 8.9 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); parathyroid gland: 8.6 nTPM (protected, limit 2); thyroid gland: 8.4 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); hypothalamus: 5.7 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 2); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000104497,SNX16,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8326% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.0933% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.0055% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.3371% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 57.8947% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.7174% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.0933% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.0828% (minimum 99%, Baseline (adaptation disabled)); colon: 70.4433% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.7561% (minimum 99%, Baseline (adaptation disabled)); esophagus: 46.8852% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.7059% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.2973% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.0821% (minimum 99%, Baseline (adaptation disabled)); liver: 72.9592% (minimum 99%, Baseline (adaptation disabled)); lung: 68.7500% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.4792% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.0821% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.6590% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.4454% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 79.8883% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.4175% (minimum 97%, Baseline (adaptation disabled)); retina: 75.2632% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.2222% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.4706% (minimum 99%, Baseline (adaptation disabled)); skin: 56.7460% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.2222% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.6420% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.7500% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.1739% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.8511% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.9956% (minimum 95%, Baseline (adaptation disabled)); tongue: 61.6379% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.7725% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,11.4,16.2,11.7,"esophagus: 16.2 nTPM (protected, limit 2); spleen: 11.7 nTPM (manageable, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); bone marrow: 10.4 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); tongue: 8.9 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); parathyroid gland: 8.6 nTPM (protected, limit 2); thyroid gland: 8.4 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); hypothalamus: 5.7 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 2); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000104497,SNX16,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.4,-0.501148,-0.43358
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8326% (minimum 95%, Missing); adrenal gland: 74.0933% (minimum 99%, Missing); amygdala: 79.0055% (minimum 99%, Missing); basal ganglia: 80.3371% (minimum 99%, Missing); bone marrow: 57.8947% (minimum 99%, Missing); cerebellum: 77.7174% (minimum 99%, Missing); cerebral cortex: 74.0933% (minimum 99%, Missing); choroid plexus: 91.0828% (minimum 99%, Missing); colon: 70.4433% (minimum 97%, Missing); duodenum: 69.7561% (minimum 99%, Missing); esophagus: 46.8852% (minimum 97%, Missing); heart muscle: 64.7059% (minimum 99%, Missing); hippocampal formation: 77.2973% (minimum 99%, Missing); hypothalamus: 71.5000% (minimum 99%, Missing); kidney: 69.0821% (minimum 99%, Missing); liver: 72.9592% (minimum 99%, Missing); lung: 68.7500% (minimum 99%, Missing); lymph node: 74.4792% (minimum 97%, Missing); midbrain: 69.0821% (minimum 99%, Missing); pancreas: 82.6590% (minimum 99%, Missing); parathyroid gland: 62.4454% (minimum 97%, Missing); pituitary gland: 79.8883% (minimum 99%, Missing); rectum: 69.4175% (minimum 97%, Missing); retina: 75.2632% (minimum 99%, Missing); salivary gland: 72.2222% (minimum 97%, Missing); skeletal muscle: 76.4706% (minimum 99%, Missing); skin: 56.7460% (minimum 95%, Missing); small intestine: 72.2222% (minimum 99%, Missing); smooth muscle: 55.6420% (minimum 99%, Missing); spinal cord: 68.7500% (minimum 99%, Missing); spleen: 55.0000% (minimum 95%, Missing); stomach: 62.1739% (minimum 97%, Missing); thymus: 60.8511% (minimum 95%, Missing); thyroid gland: 62.9956% (minimum 95%, Missing); tongue: 61.6379% (minimum 97%, Missing); urinary bladder: 67.7725% (minimum 97%, Missing)",0,5,partial,11.4,16.2,11.7,"esophagus: 16.2 nTPM (protected, limit 2); spleen: 11.7 nTPM (manageable, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); bone marrow: 10.4 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); tongue: 8.9 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); parathyroid gland: 8.6 nTPM (protected, limit 2); thyroid gland: 8.4 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); hypothalamus: 5.7 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 2); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000104497,SNX16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.4,-0.501148,-0.43358
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,187.3,0,0,"adrenal gland: 187.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000104499,GML,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 1.7314% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.0588% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,187.3,0,0,"adrenal gland: 187.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000104499,GML,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.05,0.03,-0.972686
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 1.7314% (minimum 99%, Missing); pancreas: 97.0588% (minimum 99%, Missing)",0,80,unavailable,187.3,0,0,"adrenal gland: 187.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000104499,GML,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.05,0.03,-0.972686
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000104755,ADAM2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000104755,ADAM2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000104755,ADAM2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.7,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,ENSG00000104804,TULP2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.7492% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,ENSG00000104804,TULP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.021246,0.020228,-0.012508
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.7492% (minimum 99%, Missing)",0,80,unavailable,0.7,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,ENSG00000104804,TULP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.021246,0.020228,-0.012508
True,compatible,,True,True,False,,0,1,partial,0.6,0.2,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000104818,CGB2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 93.7500% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.2353% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.4286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.7500% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.2353% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.7500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.7500% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.7500% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 78.9474% (minimum 99%, Baseline (adaptation disabled)); retina: 93.7500% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 93.7500% (minimum 99%, Baseline (adaptation disabled)); skin: 88.2353% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,0.6,0.2,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000104818,CGB2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.0676471,-0.0876471,-0.275714
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 93.7500% (minimum 97%, Supported); amygdala: 88.2353% (minimum 99%, Missing); basal ganglia: 71.4286% (minimum 99%, Missing); cerebral cortex: 93.7500% (minimum 97%, Supported); esophagus: 88.2353% (minimum 90%, Supported); heart muscle: 93.7500% (minimum 97%, Supported); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 83.3333% (minimum 99%, Missing); kidney: 93.7500% (minimum 97%, Supported); midbrain: 93.7500% (minimum 99%, Missing); pituitary gland: 78.9474% (minimum 99%, Missing); retina: 93.7500% (minimum 99%, Missing); skeletal muscle: 93.7500% (minimum 97%, Supported)",0,1,partial,0.6,0.2,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000104818,CGB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,-0.0176471,-0.275714
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,2.2,0.2,0.1,"pituitary gland: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000104827,CGB3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 96.9388% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.1966% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 82.6087% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.9381% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,2.2,0.2,0.1,"pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000104827,CGB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,0.0395833,0.00938144,-0.178034
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 81.1966% (minimum 95%, Enhanced); pituitary gland: 82.6087% (minimum 99%, Missing)",0,2,partial,2.2,0.2,0.1,"pituitary gland: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000104827,CGB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,0.05,0.03,-0.163913
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,18.2,13.9,13.9,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); esophagus: 13.9 nTPM (protected, limit 2); thyroid gland: 13.9 nTPM (manageable, limit 5); cerebral cortex: 12.7 nTPM (vital, limit 1); skin: 12 nTPM (manageable, limit 5); heart muscle: 12 nTPM (vital, limit 1); spleen: 11.7 nTPM (manageable, limit 5); pituitary gland: 11.6 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 2); tongue: 11.1 nTPM (protected, limit 2); salivary gland: 11 nTPM (protected, limit 2); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 2); lymph node: 9.6 nTPM (protected, limit 2); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 2); duodenum: 9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 2); spinal cord: 7.3 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); midbrain: 7.2 nTPM (vital, limit 1); lung: 6.4 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 2); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000104835,SARS2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6316% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 41.4634% (minimum 99%, Baseline (adaptation disabled)); amygdala: 60.4061% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.6207% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 56.3981% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 52.1930% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.3740% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.7143% (minimum 99%, Baseline (adaptation disabled)); colon: 54.8387% (minimum 97%, Baseline (adaptation disabled)); duodenum: 56.9378% (minimum 99%, Baseline (adaptation disabled)); esophagus: 46.1240% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 49.7908% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.9109% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.6207% (minimum 99%, Baseline (adaptation disabled)); kidney: 45.5939% (minimum 99%, Baseline (adaptation disabled)); liver: 39.5349% (minimum 99%, Baseline (adaptation disabled)); lung: 65.0273% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.3488% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.3037% (minimum 99%, Baseline (adaptation disabled)); pancreas: 43.4307% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.3402% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 50.6383% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 84.3972% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.9651% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 42.8058% (minimum 99%, Baseline (adaptation disabled)); skin: 49.7908% (minimum 95%, Baseline (adaptation disabled)); small intestine: 54.5872% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.4142% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.9792% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.4237% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.6383% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.9792% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 46.1240% (minimum 95%, Baseline (adaptation disabled)); tongue: 51.7391% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.6667% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,18.2,13.9,13.9,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); thyroid gland: 13.9 nTPM (manageable, limit 5); esophagus: 13.9 nTPM (protected, limit 2); cerebral cortex: 12.7 nTPM (vital, limit 1); skin: 12 nTPM (manageable, limit 5); heart muscle: 12 nTPM (vital, limit 1); spleen: 11.7 nTPM (manageable, limit 5); pituitary gland: 11.6 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 2); tongue: 11.1 nTPM (protected, limit 2); salivary gland: 11 nTPM (protected, limit 2); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 2); lymph node: 9.6 nTPM (protected, limit 2); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 2); duodenum: 9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 2); thymus: 7.3 nTPM (manageable, limit 5); spinal cord: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 2); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000104835,SARS2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.48876,-0.50876,-0.594651
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6316% (minimum 90%, Approved); adrenal gland: 41.4634% (minimum 99%, Missing); amygdala: 60.4061% (minimum 99%, Missing); basal ganglia: 58.6207% (minimum 99%, Missing); bone marrow: 56.3981% (minimum 99%, Missing); cerebellum: 52.1930% (minimum 99%, Missing); cerebral cortex: 48.3740% (minimum 99%, Missing); choroid plexus: 60.7143% (minimum 99%, Missing); colon: 54.8387% (minimum 97%, Missing); duodenum: 56.9378% (minimum 99%, Missing); esophagus: 46.1240% (minimum 97%, Missing); heart muscle: 49.7908% (minimum 99%, Missing); hippocampal formation: 58.9109% (minimum 99%, Missing); hypothalamus: 58.6207% (minimum 99%, Missing); kidney: 45.5939% (minimum 99%, Missing); liver: 39.5349% (minimum 99%, Missing); lung: 65.0273% (minimum 99%, Missing); lymph node: 55.3488% (minimum 97%, Missing); midbrain: 62.3037% (minimum 99%, Missing); pancreas: 43.4307% (minimum 99%, Missing); parathyroid gland: 61.3402% (minimum 97%, Missing); pituitary gland: 50.6383% (minimum 99%, Missing); rectum: 70.0000% (minimum 97%, Missing); retina: 84.3972% (minimum 99%, Missing); salivary gland: 51.9651% (minimum 97%, Missing); skeletal muscle: 42.8058% (minimum 99%, Missing); skin: 49.7908% (minimum 95%, Missing); small intestine: 54.5872% (minimum 99%, Missing); smooth muscle: 70.4142% (minimum 99%, Missing); spinal cord: 61.9792% (minimum 99%, Missing); spleen: 50.4237% (minimum 95%, Missing); stomach: 50.6383% (minimum 97%, Missing); thymus: 61.9792% (minimum 95%, Missing); thyroid gland: 46.1240% (minimum 95%, Missing); tongue: 51.7391% (minimum 97%, Missing); urinary bladder: 56.6667% (minimum 97%, Missing)",0,2,partial,18.2,13.9,13.9,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); esophagus: 13.9 nTPM (protected, limit 2); thyroid gland: 13.9 nTPM (manageable, limit 5); cerebral cortex: 12.7 nTPM (vital, limit 1); skin: 12 nTPM (manageable, limit 5); heart muscle: 12 nTPM (vital, limit 1); spleen: 11.7 nTPM (manageable, limit 5); pituitary gland: 11.6 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 2); tongue: 11.1 nTPM (protected, limit 2); salivary gland: 11 nTPM (protected, limit 2); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 2); lymph node: 9.6 nTPM (protected, limit 2); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 2); duodenum: 9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 2); spinal cord: 7.3 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); midbrain: 7.2 nTPM (vital, limit 1); lung: 6.4 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 2); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000104835,SARS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.48876,-0.50876,-0.594651
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,30.3,29,35.1,"spleen: 35.1 nTPM (manageable, limit 5); thymus: 32.2 nTPM (manageable, limit 5); small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 2); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 2); colon: 21.5 nTPM (protected, limit 2); pancreas: 20.4 nTPM (vital, limit 1); esophagus: 19.3 nTPM (protected, limit 2); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 2); cerebellum: 14.6 nTPM (vital, limit 2); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 2); smooth muscle: 13.4 nTPM (vital, limit 2); skin: 13.3 nTPM (manageable, limit 5); duodenum: 13 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 4); salivary gland: 10.6 nTPM (protected, limit 2); thyroid gland: 10.5 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); rectum: 7.5 nTPM (protected, limit 2); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000104880,ARHGEF18,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.2199% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 51.2658% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.7786% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 57.4468% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 37.6744% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 52.5974% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.4286% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.0244% (minimum 99%, Baseline (adaptation disabled)); colon: 42.9708% (minimum 97%, Baseline (adaptation disabled)); duodenum: 55.4795% (minimum 99%, Baseline (adaptation disabled)); esophagus: 45.6338% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.1299% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 56.0554% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.5970% (minimum 99%, Baseline (adaptation disabled)); kidney: 40.9091% (minimum 99%, Baseline (adaptation disabled)); liver: 56.0554% (minimum 99%, Baseline (adaptation disabled)); lung: 53.4653% (minimum 99%, Baseline (adaptation disabled)); lymph node: 35.8407% (minimum 97%, Baseline (adaptation disabled)); midbrain: 58.6957% (minimum 99%, Baseline (adaptation disabled)); pancreas: 44.2623% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 51.2658% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.3544% (minimum 97%, Baseline (adaptation disabled)); retina: 77.1429% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.4478% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.0563% (minimum 99%, Baseline (adaptation disabled)); skin: 54.9153% (minimum 95%, Baseline (adaptation disabled)); small intestine: 34.8387% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 54.7297% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.8571% (minimum 99%, Baseline (adaptation disabled)); spleen: 31.5789% (minimum 95%, Baseline (adaptation disabled)); stomach: 42.5197% (minimum 97%, Baseline (adaptation disabled)); thymus: 33.4711% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.6742% (minimum 95%, Baseline (adaptation disabled)); tongue: 85.2632% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.5455% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,30.3,29,35.1,"spleen: 35.1 nTPM (manageable, limit 5); thymus: 32.2 nTPM (manageable, limit 5); small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 2); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 2); colon: 21.5 nTPM (protected, limit 2); pancreas: 20.4 nTPM (vital, limit 1); esophagus: 19.3 nTPM (protected, limit 2); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 2); smooth muscle: 13.4 nTPM (vital, limit 1); skin: 13.3 nTPM (manageable, limit 5); duodenum: 13 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); salivary gland: 10.6 nTPM (protected, limit 2); thyroid gland: 10.5 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); adipose tissue: 7.9 nTPM (manageable, limit 5); rectum: 7.5 nTPM (protected, limit 2); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000104880,ARHGEF18,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.634211,-0.611593,-0.641613
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.2199% (minimum 90%, Approved); adrenal gland: 51.2658% (minimum 99%, Missing); amygdala: 59.7786% (minimum 99%, Missing); basal ganglia: 57.4468% (minimum 99%, Missing); bone marrow: 37.6744% (minimum 99%, Missing); cerebellum: 52.5974% (minimum 98%, Approved); cerebral cortex: 51.4286% (minimum 98%, Approved); choroid plexus: 79.0244% (minimum 99%, Missing); colon: 42.9708% (minimum 97%, Missing); duodenum: 55.4795% (minimum 99%, Missing); esophagus: 45.6338% (minimum 97%, Missing); heart muscle: 70.1299% (minimum 99%, Missing); hippocampal formation: 56.0554% (minimum 99%, Missing); hypothalamus: 61.5970% (minimum 99%, Missing); kidney: 40.9091% (minimum 99%, Missing); liver: 56.0554% (minimum 98%, Approved); lung: 53.4653% (minimum 99%, Missing); lymph node: 35.8407% (minimum 97%, Missing); midbrain: 58.6957% (minimum 99%, Missing); pancreas: 44.2623% (minimum 99%, Missing); parathyroid gland: 60.0000% (minimum 95%, Approved); pituitary gland: 51.2658% (minimum 99%, Missing); rectum: 68.3544% (minimum 97%, Missing); retina: 77.1429% (minimum 99%, Missing); salivary gland: 60.4478% (minimum 97%, Missing); skeletal muscle: 76.0563% (minimum 99%, Missing); skin: 54.9153% (minimum 95%, Missing); small intestine: 34.8387% (minimum 99%, Missing); smooth muscle: 54.7297% (minimum 98%, Approved); spinal cord: 57.8571% (minimum 99%, Missing); spleen: 31.5789% (minimum 95%, Missing); stomach: 42.5197% (minimum 97%, Missing); thymus: 33.4711% (minimum 95%, Missing); thyroid gland: 60.6742% (minimum 95%, Missing); tongue: 85.2632% (minimum 97%, Missing); urinary bladder: 54.5455% (minimum 97%, Missing)",0,5,partial,30.3,29,35.1,"spleen: 35.1 nTPM (manageable, limit 5); thymus: 32.2 nTPM (manageable, limit 5); small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 2); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 2); colon: 21.5 nTPM (protected, limit 2); pancreas: 20.4 nTPM (vital, limit 1); esophagus: 19.3 nTPM (protected, limit 2); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 2); cerebellum: 14.6 nTPM (vital, limit 2); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 2); smooth muscle: 13.4 nTPM (vital, limit 2); skin: 13.3 nTPM (manageable, limit 5); duodenum: 13 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 4); salivary gland: 10.6 nTPM (protected, limit 2); thyroid gland: 10.5 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); rectum: 7.5 nTPM (protected, limit 2); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000104880,ARHGEF18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.634211,-0.611593,-0.641613
True,compatible,,True,True,False,,0,1,partial,0.9,0.9,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000104901,DKKL1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.9,0.9,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000104901,DKKL1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.047916,0.0273222,0.00732223
True,compatible,,True,True,True,,0,1,partial,0.9,0.9,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000104901,DKKL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.0291058,0.00910581
True,compatible,,True,True,False,,0,2,partial,0,0,2.7,,,52,not_established,not_triggered,,,ENSG00000104941,RSPH6A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thyroid gland: 91.4557% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,0,0,2.7,,,52,not_established,not_triggered,,,ENSG00000104941,RSPH6A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.035443,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,2.7,,,52,not_established,not_triggered,,,ENSG00000104941,RSPH6A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,11,partial,4.7,9,3.9,"lymph node: 9 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / cells in spinous layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / langerhans cells: High (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 1 / sebaceous glands: High (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: High (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / langerhans cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / sebaceous glands; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000104951,IL4I1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.5455% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.1132% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.6543% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.1132% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 86.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.8593% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.5882% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.0149% (minimum 99%, Baseline (adaptation disabled)); colon: 94.5455% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.1356% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.1132% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.2963% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.7444% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.6906% (minimum 99%, Baseline (adaptation disabled)); liver: 95.5882% (minimum 99%, Baseline (adaptation disabled)); lung: 91.8728% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.2857% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.6543% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.3783% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.1132% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.2381% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.8593% (minimum 99%, Baseline (adaptation disabled)); small intestine: 90.9091% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.8905% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.5455% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.9565% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.2778% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.0411% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 85.8086% (minimum 97%, Baseline (adaptation disabled))",0,11,partial,4.7,9,3.9,"lymph node: 9 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / cells in spinous layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / langerhans cells: High (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 1 / sebaceous glands: High (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: High (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / langerhans cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / sebaceous glands; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000104951,IL4I1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.0804348,-0.227143,-0.143094
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.6543% (minimum 99%, Missing); basal ganglia: 98.1132% (minimum 99%, Missing); bone marrow: 86.6667% (minimum 99%, Missing); cerebellum: 98.8593% (minimum 99%, Missing); choroid plexus: 97.0149% (minimum 99%, Missing); colon: 94.5455% (minimum 97%, Missing); duodenum: 88.1356% (minimum 99%, Missing); hippocampal formation: 96.2963% (minimum 99%, Missing); hypothalamus: 97.7444% (minimum 99%, Missing); kidney: 84.6906% (minimum 99%, Missing); lung: 91.8728% (minimum 99%, Missing); lymph node: 74.2857% (minimum 97%, Missing); midbrain: 96.6543% (minimum 99%, Missing); pituitary gland: 98.1132% (minimum 99%, Missing); rectum: 95.2381% (minimum 97%, Missing); small intestine: 90.9091% (minimum 99%, Missing); smooth muscle: 94.8905% (minimum 95%, Enhanced); spinal cord: 94.5455% (minimum 99%, Missing); spleen: 86.9565% (minimum 95%, Missing); thymus: 89.0411% (minimum 95%, Missing)",0,11,partial,4.7,9,3.9,"lymph node: 9 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / cells in spinous layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / langerhans cells: High (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 1 / sebaceous glands: High (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: High (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / langerhans cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / sebaceous glands; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000104951,IL4I1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.0804348,-0.227143,-0.143094
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,11.5,12.2,22.6,"thymus: 22.6 nTPM (manageable, limit 5); lymph node: 12.2 nTPM (protected, limit 2); bone marrow: 11.5 nTPM (vital, limit 6); rectum: 7.5 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000105011,ASF1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.6923% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.0047% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7302% (minimum 99%, Baseline (adaptation disabled)); colon: 81.2010% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.9116% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.6691% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.1073% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.8847% (minimum 99%, Baseline (adaptation disabled)); liver: 96.2848% (minimum 99%, Baseline (adaptation disabled)); lung: 93.9577% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.8245% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.1073% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.7987% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.5699% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 94.2424% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.4177% (minimum 99%, Baseline (adaptation disabled)); skin: 90.9357% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.2818% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.2424% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.4934% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.9357% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.9143% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.8171% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,11.5,12.2,22.6,"thymus: 22.6 nTPM (manageable, limit 5); lymph node: 12.2 nTPM (protected, limit 2); bone marrow: 11.5 nTPM (vital, limit 1); esophagus: 10 nTPM (protected, limit 2); rectum: 7.5 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); spleen: 6.6 nTPM (manageable, limit 5); small intestine: 5.8 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000105011,ASF1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.370857,-0.251755,-0.259953
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.6923% (minimum 99%, Missing); bone marrow: 73.0047% (minimum 95%, Enhanced); cerebral cortex: 98.7302% (minimum 99%, Missing); colon: 81.2010% (minimum 97%, Missing); duodenum: 85.9116% (minimum 99%, Missing); esophagus: 75.6691% (minimum 80%, Enhanced); heart muscle: 98.1073% (minimum 99%, Missing); kidney: 96.8847% (minimum 99%, Missing); lung: 93.9577% (minimum 95%, Enhanced); lymph node: 71.8245% (minimum 97%, Missing); pancreas: 98.1073% (minimum 99%, Missing); pituitary gland: 97.7987% (minimum 99%, Missing); rectum: 80.5699% (minimum 97%, Missing); salivary gland: 94.2424% (minimum 97%, Missing); small intestine: 84.2818% (minimum 99%, Missing); smooth muscle: 94.2424% (minimum 95%, Enhanced); thymus: 57.9143% (minimum 95%, Missing); urinary bladder: 94.8171% (minimum 97%, Missing)",0,6,partial,11.5,12.2,22.6,"thymus: 22.6 nTPM (manageable, limit 5); lymph node: 12.2 nTPM (protected, limit 2); bone marrow: 11.5 nTPM (vital, limit 6); rectum: 7.5 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000105011,ASF1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.370857,-0.251755,-0.219953
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,10.9,5.1,6.2,"bone marrow: 10.9 nTPM (vital, limit 6); skeletal muscle: 6.7 nTPM (vital, limit 6); colon: 3.9 nTPM (protected, limit 2); pituitary gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105085,MED26,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 88.8041% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.6494% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.3280% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.0844% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.2009% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.8041% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.3280% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.0844% (minimum 99%, Baseline (adaptation disabled)); colon: 89.9485% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.8172% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.2500% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.8421% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.3280% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.8421% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.8191% (minimum 99%, Baseline (adaptation disabled)); liver: 90.6494% (minimum 99%, Baseline (adaptation disabled)); lung: 89.9485% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.1313% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.3155% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.1809% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.1227% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.8854% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.0954% (minimum 97%, Baseline (adaptation disabled)); retina: 94.5799% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.8041% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.8942% (minimum 99%, Baseline (adaptation disabled)); skin: 84.9148% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.8854% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.5657% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.3613% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.3544% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.8854% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.0306% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.0844% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.8421% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.4145% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,10.9,5.1,6.2,"bone marrow: 10.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 2); lymph node: 4.7 nTPM (protected, limit 2); cerebellum: 4.4 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); pancreas: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); small intestine: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105085,MED26,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.100852,-0.0975,-0.227991
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.6494% (minimum 95%, Enhanced); amygdala: 92.3280% (minimum 99%, Missing); basal ganglia: 92.0844% (minimum 99%, Missing); bone marrow: 76.2009% (minimum 95%, Enhanced); cerebellum: 88.8041% (minimum 95%, Enhanced); cerebral cortex: 92.3280% (minimum 95%, Enhanced); choroid plexus: 92.0844% (minimum 99%, Missing); colon: 89.9485% (minimum 97%, Missing); duodenum: 93.8172% (minimum 95%, Enhanced); heart muscle: 91.8421% (minimum 95%, Enhanced); hippocampal formation: 92.3280% (minimum 99%, Missing); hypothalamus: 91.8421% (minimum 99%, Missing); kidney: 92.8191% (minimum 95%, Enhanced); liver: 90.6494% (minimum 95%, Enhanced); lung: 89.9485% (minimum 95%, Enhanced); midbrain: 93.3155% (minimum 99%, Missing); pancreas: 90.1809% (minimum 95%, Enhanced); pituitary gland: 90.8854% (minimum 99%, Missing); retina: 94.5799% (minimum 99%, Missing); skeletal muscle: 83.8942% (minimum 95%, Enhanced); small intestine: 90.8854% (minimum 95%, Enhanced); smooth muscle: 93.5657% (minimum 95%, Enhanced); spinal cord: 91.3613% (minimum 99%, Missing); thymus: 89.0306% (minimum 95%, Missing); tongue: 91.8421% (minimum 97%, Missing)",0,8,partial,10.9,5.1,6.2,"bone marrow: 10.9 nTPM (vital, limit 6); skeletal muscle: 6.7 nTPM (vital, limit 6); colon: 3.9 nTPM (protected, limit 2); pituitary gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105085,MED26,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0596939,-0.0705155,-0.187991
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,11,partial,117.1,0.9,8.3,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / endothelial cells: High (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil,ENSG00000105143,SLC1A6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 77.9370% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.5102% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.7972% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 18.8496% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.2842% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.1949% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9091% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 69.3878% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.9223% (minimum 99%, Baseline (adaptation disabled)); midbrain: 89.4737% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.8417% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.7972% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.9091% (minimum 99%, Baseline (adaptation disabled)); retina: 92.5170% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.9091% (minimum 99%, Baseline (adaptation disabled)); skin: 76.6197% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 89.1803% (minimum 99%, Baseline (adaptation disabled))",0,11,partial,117.1,0.9,8.3,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / endothelial cells: High (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil,ENSG00000105143,SLC1A6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.183803,-0.00202847,-0.801504
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 77.9370% (minimum 99%, Missing); basal ganglia: 55.5102% (minimum 99%, Missing); cerebellum: 18.8496% (minimum 99%, Missing); cerebral cortex: 70.2842% (minimum 99%, Missing); choroid plexus: 98.1949% (minimum 99%, Missing); hippocampal formation: 69.3878% (minimum 99%, Missing); hypothalamus: 72.9223% (minimum 99%, Missing); midbrain: 89.4737% (minimum 99%, Missing); pituitary gland: 98.9091% (minimum 99%, Missing); retina: 92.5170% (minimum 99%, Missing); skeletal muscle: 98.9091% (minimum 99%, Missing); skin: 76.6197% (minimum 95%, Missing); spinal cord: 89.1803% (minimum 99%, Missing)",0,11,partial,117.1,0.9,8.3,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / endothelial cells: High (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil,ENSG00000105143,SLC1A6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.183803,0.0227007,-0.801504
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.6,3.4,4.9,"choroid plexus: 3.6 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105146,AURKC,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8355% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.9957% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.9957% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.9957% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.6242% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.7589% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.6230% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.1702% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.7880% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1702% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.9957% (minimum 99%, Baseline (adaptation disabled)); liver: 94.5607% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0477% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.0041% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.7627% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0477% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.4138% (minimum 99%, Baseline (adaptation disabled)); retina: 97.6242% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.3753% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.4749% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.6242% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.1959% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.2196% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.6,3.4,4.9,"choroid plexus: 3.6 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105146,AURKC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0478044,-0.0399588,-0.0637705
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8355% (minimum 99%, Missing); amygdala: 96.9957% (minimum 99%, Missing); basal ganglia: 96.9957% (minimum 99%, Missing); bone marrow: 96.9957% (minimum 99%, Missing); cerebellum: 97.6242% (minimum 99%, Missing); cerebral cortex: 94.7589% (minimum 99%, Missing); choroid plexus: 92.6230% (minimum 99%, Missing); heart muscle: 96.1702% (minimum 99%, Missing); hippocampal formation: 96.7880% (minimum 99%, Missing); hypothalamus: 96.1702% (minimum 99%, Missing); kidney: 96.9957% (minimum 99%, Missing); liver: 94.5607% (minimum 99%, Missing); lung: 98.0477% (minimum 99%, Missing); lymph node: 93.0041% (minimum 97%, Missing); midbrain: 95.7627% (minimum 99%, Missing); pancreas: 98.0477% (minimum 99%, Missing); pituitary gland: 97.4138% (minimum 99%, Missing); retina: 97.6242% (minimum 99%, Missing); skeletal muscle: 96.3753% (minimum 99%, Missing); small intestine: 98.4749% (minimum 99%, Missing); smooth muscle: 97.6242% (minimum 99%, Missing); spinal cord: 93.1959% (minimum 99%, Missing); spleen: 90.2196% (minimum 95%, Missing)",0,80,unavailable,3.6,3.4,4.9,"choroid plexus: 3.6 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105146,AURKC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0478044,-0.0399588,-0.0637705
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,ENSG00000105198,LGALS13,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.1982% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,ENSG00000105198,LGALS13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.0209091,-0.00801802
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.1982% (minimum 99%, Missing)",0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,ENSG00000105198,LGALS13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.0209091,-0.00801802
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,8.1,19.7,33.1,"spleen: 33.1 nTPM (manageable, limit 30); lymph node: 19.7 nTPM (protected, limit 12); thymus: 9.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105246,EBI3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.0756% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.6860% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7543% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.0088% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.2071% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2782% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.4817% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6178% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8067% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0756% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.8695% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.4061% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.3460% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.8227% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.6286% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5497% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.6148% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.1718% (minimum 95%, Baseline (adaptation disabled)); thymus: 93.9434% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.8771% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,8.1,19.7,33.1,"spleen: 33.1 nTPM (manageable, limit 5); lymph node: 19.7 nTPM (protected, limit 2); thymus: 9.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); liver: 3.2 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); amygdala: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105246,EBI3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.138282,-0.0913054,-0.0437135
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.0756% (minimum 99%, Missing); basal ganglia: 98.6860% (minimum 99%, Missing); choroid plexus: 97.0088% (minimum 99%, Missing); hippocampal formation: 98.2782% (minimum 99%, Missing); hypothalamus: 98.4817% (minimum 99%, Missing); midbrain: 97.4061% (minimum 99%, Missing); pituitary gland: 98.8227% (minimum 99%, Missing); small intestine: 94.6286% (minimum 95%, Enhanced); spinal cord: 96.6148% (minimum 99%, Missing); thymus: 93.9434% (minimum 95%, Missing)",0,3,partial,8.1,19.7,33.1,"spleen: 33.1 nTPM (manageable, limit 30); lymph node: 19.7 nTPM (protected, limit 12); thymus: 9.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105246,EBI3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.0105662,0.0272048,-0.0238524
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,ENSG00000105261,OVOL3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.3684% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.3684% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 94.8718% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 94.8718% (minimum 99%, Baseline (adaptation disabled)); skin: 82.2222% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,ENSG00000105261,OVOL3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.127778,0.00368421,-0.065
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.3684% (minimum 99%, Missing); cerebellum: 97.3684% (minimum 99%, Missing); pituitary gland: 92.5000% (minimum 99%, Missing); retina: 94.8718% (minimum 99%, Missing); skeletal muscle: 94.8718% (minimum 99%, Missing); skin: 82.2222% (minimum 95%, Missing)",0,80,unavailable,0.3,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,ENSG00000105261,OVOL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.127778,0.00368421,-0.065
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,215.1,72.7,15.8,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 2); urinary bladder: 66 nTPM (protected, limit 2); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 2); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (manageable, limit 5); esophagus: 15.7 nTPM (protected, limit 2); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); spleen: 9.7 nTPM (manageable, limit 5); lung: 9.7 nTPM (vital, limit 1); thymus: 9.2 nTPM (manageable, limit 5); rectum: 8.3 nTPM (protected, limit 2); skin: 7.6 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); thyroid gland: 5.4 nTPM (manageable, limit 5); pancreas: 3.5 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105270,CLIP3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.2005% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.0091% (minimum 99%, Baseline (adaptation disabled)); amygdala: 29.6984% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 32.5203% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 22.9308% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 23.0299% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.3031% (minimum 99%, Baseline (adaptation disabled)); colon: 46.8178% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.0384% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.3011% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.8794% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 31.6362% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 29.9625% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.1064% (minimum 99%, Baseline (adaptation disabled)); liver: 95.8084% (minimum 99%, Baseline (adaptation disabled)); lung: 86.8385% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.3955% (minimum 97%, Baseline (adaptation disabled)); midbrain: 35.1455% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.8148% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.2406% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.3409% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.5201% (minimum 97%, Baseline (adaptation disabled)); retina: 54.6075% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.2981% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); skin: 89.3855% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.4717% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.6183% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 41.5584% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.8385% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.0721% (minimum 97%, Baseline (adaptation disabled)); thymus: 87.4317% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.2190% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.9555% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 49.2308% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,215.1,72.7,15.8,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 2); urinary bladder: 66 nTPM (protected, limit 2); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 2); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (manageable, limit 5); esophagus: 15.7 nTPM (protected, limit 2); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); spleen: 9.7 nTPM (manageable, limit 5); lung: 9.7 nTPM (vital, limit 1); thymus: 9.2 nTPM (manageable, limit 5); rectum: 8.3 nTPM (protected, limit 2); skin: 7.6 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); thyroid gland: 5.4 nTPM (manageable, limit 5); pancreas: 3.5 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105270,CLIP3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.147995,-0.501822,-0.760692
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.2005% (minimum 95%, Missing); adrenal gland: 83.0091% (minimum 99%, Missing); amygdala: 29.6984% (minimum 99%, Missing); basal ganglia: 32.5203% (minimum 99%, Missing); cerebellum: 22.9308% (minimum 99%, Missing); cerebral cortex: 23.0299% (minimum 99%, Missing); choroid plexus: 68.3031% (minimum 99%, Missing); colon: 46.8178% (minimum 97%, Missing); duodenum: 91.0384% (minimum 99%, Missing); esophagus: 80.3011% (minimum 97%, Missing); heart muscle: 83.8794% (minimum 99%, Missing); hippocampal formation: 31.6362% (minimum 99%, Missing); hypothalamus: 29.9625% (minimum 99%, Missing); kidney: 85.1064% (minimum 99%, Missing); liver: 95.8084% (minimum 99%, Missing); lung: 86.8385% (minimum 99%, Missing); lymph node: 90.3955% (minimum 97%, Missing); midbrain: 35.1455% (minimum 99%, Missing); pancreas: 94.8148% (minimum 99%, Missing); parathyroid gland: 96.2406% (minimum 97%, Missing); pituitary gland: 58.3409% (minimum 99%, Missing); rectum: 88.5201% (minimum 97%, Missing); retina: 54.6075% (minimum 99%, Missing); salivary gland: 91.2981% (minimum 97%, Missing); skeletal muscle: 95.2381% (minimum 99%, Missing); skin: 89.3855% (minimum 95%, Missing); small intestine: 75.4717% (minimum 99%, Missing); smooth muscle: 63.6183% (minimum 99%, Missing); spinal cord: 41.5584% (minimum 99%, Missing); spleen: 86.8385% (minimum 95%, Missing); stomach: 72.0721% (minimum 97%, Missing); thymus: 87.4317% (minimum 95%, Missing); thyroid gland: 92.2190% (minimum 95%, Missing); tongue: 94.9555% (minimum 97%, Missing); urinary bladder: 49.2308% (minimum 97%, Missing)",0,80,unavailable,215.1,72.7,15.8,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 2); urinary bladder: 66 nTPM (protected, limit 2); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 2); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (manageable, limit 5); esophagus: 15.7 nTPM (protected, limit 2); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); spleen: 9.7 nTPM (manageable, limit 5); lung: 9.7 nTPM (vital, limit 1); thymus: 9.2 nTPM (manageable, limit 5); rectum: 8.3 nTPM (protected, limit 2); skin: 7.6 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); thyroid gland: 5.4 nTPM (manageable, limit 5); pancreas: 3.5 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105270,CLIP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.147995,-0.501822,-0.760692
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000105428,ZNRF4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000105428,ZNRF4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00828914
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000105428,ZNRF4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00828914
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,6.1,3.8,0.1,"cerebellum: 6.1 nTPM (vital, limit 6)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,not_triggered,,,ENSG00000105467,SYNGR4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.6940% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.6610% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.7093% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1447% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.2981% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,6.1,3.8,0.1,"cerebellum: 6.1 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebral cortex: 1.8 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,not_triggered,,,ENSG00000105467,SYNGR4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0481132,-0.0370194,-0.0933898
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.6940% (minimum 99%, Missing); cerebellum: 89.6610% (minimum 95%, Enhanced)",0,4,partial,6.1,3.8,0.1,"cerebellum: 6.1 nTPM (vital, limit 6)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,not_triggered,,,ENSG00000105467,SYNGR4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.0262335,-0.0533898
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,28.3,0.6,0.5,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus,ENSG00000105479,ODAD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.0159% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.3668% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0159% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 46.6038% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.1089% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.6360% (minimum 99%, Baseline (adaptation disabled)); lung: 89.4928% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.4064% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4064% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,28.3,0.6,0.5,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus,ENSG00000105479,ODAD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0301587,0.00628458,-0.523962
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.0159% (minimum 99%, Missing); basal ganglia: 95.3668% (minimum 99%, Missing); choroid plexus: 46.6038% (minimum 99%, Missing); hippocampal formation: 96.1089% (minimum 99%, Missing); hypothalamus: 94.6360% (minimum 99%, Missing); lung: 89.4928% (minimum 98%, Approved); pituitary gland: 98.4064% (minimum 99%, Missing); retina: 98.4064% (minimum 99%, Missing)",0,6,partial,28.3,0.6,0.5,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus,ENSG00000105479,ODAD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0419679,0.0262846,-0.523962
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,4.3,3.7,1.7,"small intestine: 3.2 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105492,SIGLEC6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 97.9107% (minimum 99%, Baseline (adaptation disabled)); lung: 95.9963% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.5356% (minimum 97%, Baseline (adaptation disabled)); small intestine: 96.9897% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7548% (minimum 99%, Baseline (adaptation disabled))",0,8,partial,4.3,3.7,1.7,"lung: 4.3 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105492,SIGLEC6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0337786,-0.00464419,-0.0300372
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 97.9107% (minimum 99%, Missing); small intestine: 96.9897% (minimum 99%, Missing)",0,8,partial,4.3,3.7,1.7,"small intestine: 3.2 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105492,SIGLEC6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0432563,0.00172479,-0.0201035
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.3,2.7,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000105549,THEG,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.0998% (minimum 99%, Baseline (adaptation disabled)); skin: 93.8636% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.3,2.7,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000105549,THEG,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,-0.0113636,0.0227885,-0.00900238
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.0998% (minimum 99%, Missing); skin: 93.8636% (minimum 95%, Missing)",0,80,unavailable,0.8,0.3,2.7,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000105549,THEG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,-0.0113636,0.0227885,-0.00900238
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,42.4,25.3,25.7,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); skin: 25.7 nTPM (manageable, limit 5); esophagus: 25.3 nTPM (protected, limit 2); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 2); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 2); stomach: 14.7 nTPM (protected, limit 2); salivary gland: 14.5 nTPM (protected, limit 2); hypothalamus: 13 nTPM (vital, limit 1); colon: 13 nTPM (protected, limit 2); heart muscle: 12.3 nTPM (vital, limit 2); skeletal muscle: 12 nTPM (vital, limit 2); thymus: 11.3 nTPM (manageable, limit 5); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 2); smooth muscle: 9.4 nTPM (vital, limit 2); rectum: 9.3 nTPM (protected, limit 2); kidney: 9.3 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105647,PIK3R2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.8201% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 45.6140% (minimum 99%, Baseline (adaptation disabled)); amygdala: 40.3883% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 38.4473% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.4211% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.3081% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 34.4371% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.1955% (minimum 99%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.9804% (minimum 99%, Baseline (adaptation disabled)); esophagus: 45.1193% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.8399% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 32.9114% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.5385% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.1030% (minimum 99%, Baseline (adaptation disabled)); liver: 66.8810% (minimum 99%, Baseline (adaptation disabled)); lung: 70.2703% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.3089% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.0317% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.8557% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 49.8801% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.1030% (minimum 97%, Baseline (adaptation disabled)); retina: 73.2394% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.9235% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.4146% (minimum 99%, Baseline (adaptation disabled)); skin: 44.7312% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.2162% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.8742% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.7483% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.9898% (minimum 95%, Baseline (adaptation disabled)); stomach: 58.5915% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.7975% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 67.0968% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.6469% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.4270% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,42.4,25.3,25.7,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); skin: 25.7 nTPM (manageable, limit 5); esophagus: 25.3 nTPM (protected, limit 2); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 2); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 2); stomach: 14.7 nTPM (protected, limit 2); salivary gland: 14.5 nTPM (protected, limit 2); hypothalamus: 13 nTPM (vital, limit 1); colon: 13 nTPM (protected, limit 2); heart muscle: 12.3 nTPM (vital, limit 1); skeletal muscle: 12 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 2); smooth muscle: 9.4 nTPM (vital, limit 1); rectum: 9.3 nTPM (protected, limit 2); kidney: 9.3 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105647,PIK3R2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.502688,-0.518807,-0.660886
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.8201% (minimum 95%, Missing); adrenal gland: 45.6140% (minimum 99%, Missing); amygdala: 40.3883% (minimum 99%, Missing); basal ganglia: 38.4473% (minimum 99%, Missing); bone marrow: 68.4211% (minimum 99%, Missing); cerebellum: 54.3081% (minimum 99%, Missing); cerebral cortex: 34.4371% (minimum 99%, Missing); choroid plexus: 78.1955% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 50.9804% (minimum 99%, Missing); esophagus: 45.1193% (minimum 97%, Missing); heart muscle: 62.8399% (minimum 98%, Approved); hippocampal formation: 32.9114% (minimum 99%, Missing); hypothalamus: 61.5385% (minimum 99%, Missing); kidney: 69.1030% (minimum 99%, Missing); liver: 66.8810% (minimum 99%, Missing); lung: 70.2703% (minimum 99%, Missing); lymph node: 80.3089% (minimum 97%, Missing); midbrain: 69.3333% (minimum 99%, Missing); pancreas: 66.0317% (minimum 99%, Missing); parathyroid gland: 50.8557% (minimum 97%, Missing); pituitary gland: 49.8801% (minimum 99%, Missing); rectum: 69.1030% (minimum 97%, Missing); retina: 73.2394% (minimum 99%, Missing); salivary gland: 58.9235% (minimum 97%, Missing); skeletal muscle: 63.4146% (minimum 98%, Approved); skin: 44.7312% (minimum 95%, Missing); small intestine: 56.2162% (minimum 99%, Missing); smooth muscle: 68.8742% (minimum 98%, Approved); spinal cord: 70.7483% (minimum 99%, Missing); spleen: 70.9898% (minimum 95%, Missing); stomach: 58.5915% (minimum 97%, Missing); thymus: 64.7975% (minimum 95%, Missing); thyroid gland: 67.0968% (minimum 95%, Missing); tongue: 68.6469% (minimum 97%, Missing); urinary bladder: 58.4270% (minimum 97%, Missing)",0,1,partial,42.4,25.3,25.7,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); skin: 25.7 nTPM (manageable, limit 5); esophagus: 25.3 nTPM (protected, limit 2); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 2); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 2); stomach: 14.7 nTPM (protected, limit 2); salivary gland: 14.5 nTPM (protected, limit 2); hypothalamus: 13 nTPM (vital, limit 1); colon: 13 nTPM (protected, limit 2); heart muscle: 12.3 nTPM (vital, limit 2); skeletal muscle: 12 nTPM (vital, limit 2); thymus: 11.3 nTPM (manageable, limit 5); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 2); smooth muscle: 9.4 nTPM (vital, limit 2); rectum: 9.3 nTPM (protected, limit 2); kidney: 9.3 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105647,PIK3R2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.502688,-0.518807,-0.660886
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.3,1.9,1.6,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105672,ETV2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.3608% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.8836% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.9305% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.8836% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.3542% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.4043% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.3684% (minimum 99%, Baseline (adaptation disabled)); colon: 95.3608% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.5000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.1330% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.8836% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.4043% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.4043% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.8549% (minimum 99%, Baseline (adaptation disabled)); liver: 93.4343% (minimum 99%, Baseline (adaptation disabled)); lung: 96.8586% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.4043% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.9423% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.8718% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.8586% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4043% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.6863% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.9305% (minimum 99%, Baseline (adaptation disabled)); skin: 92.0398% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.3878% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.4043% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.4043% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.3608% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.8586% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.3,1.9,1.6,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105672,ETV2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.029602,-0.0631373,-0.100577
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.3608% (minimum 99%, Missing); amygdala: 97.8836% (minimum 99%, Missing); basal ganglia: 98.9305% (minimum 99%, Missing); bone marrow: 97.8836% (minimum 99%, Missing); cerebellum: 96.3542% (minimum 99%, Missing); cerebral cortex: 98.4043% (minimum 99%, Missing); choroid plexus: 97.3684% (minimum 99%, Missing); colon: 95.3608% (minimum 97%, Missing); duodenum: 92.5000% (minimum 99%, Missing); esophagus: 91.1330% (minimum 97%, Missing); heart muscle: 97.8836% (minimum 99%, Missing); hippocampal formation: 98.4043% (minimum 99%, Missing); hypothalamus: 98.4043% (minimum 99%, Missing); kidney: 95.8549% (minimum 99%, Missing); liver: 93.4343% (minimum 99%, Missing); lung: 96.8586% (minimum 99%, Missing); midbrain: 98.4043% (minimum 99%, Missing); pancreas: 88.9423% (minimum 99%, Missing); parathyroid gland: 94.8718% (minimum 97%, Missing); pituitary gland: 96.8586% (minimum 99%, Missing); retina: 98.4043% (minimum 99%, Missing); salivary gland: 90.6863% (minimum 97%, Missing); skeletal muscle: 98.9305% (minimum 99%, Missing); skin: 92.0398% (minimum 95%, Missing); small intestine: 94.3878% (minimum 99%, Missing); smooth muscle: 98.4043% (minimum 99%, Missing); spinal cord: 98.4043% (minimum 99%, Missing); stomach: 95.3608% (minimum 97%, Missing); urinary bladder: 96.8586% (minimum 97%, Missing)",0,80,unavailable,2.3,1.9,1.6,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105672,ETV2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.029602,-0.0631373,-0.100577
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,5,6.3,13.5,"retina: 3.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000105679,GAPDHS,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 98.7947% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5349% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1294% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7204% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8320% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,5,6.3,13.5,"skin: 13.5 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 2); spleen: 5.1 nTPM (manageable, limit 5); salivary gland: 5 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); adrenal gland: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000105679,GAPDHS,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.00105149,0.00654505,-0.00870557
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.7204% (minimum 99%, Missing)",0,3,partial,5,6.3,13.5,"retina: 3.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000105679,GAPDHS,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.00279639
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,32.7,15.9,11,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 2); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 2); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105737,GRIK5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.3955% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.4397% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.8365% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.2190% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 49.4590% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.9629% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.0513% (minimum 99%, Baseline (adaptation disabled)); colon: 66.8058% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.8593% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.8084% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.9565% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.5385% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.5105% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.4742% (minimum 99%, Baseline (adaptation disabled)); lung: 98.4615% (minimum 99%, Baseline (adaptation disabled)); midbrain: 78.2396% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.2945% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.8690% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.2570% (minimum 99%, Baseline (adaptation disabled)); retina: 72.8929% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.4615% (minimum 99%, Baseline (adaptation disabled)); small intestine: 90.6516% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.9565% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.8876% (minimum 99%, Baseline (adaptation disabled)); stomach: 86.2534% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 74.4186% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 86.9565% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,32.7,15.9,11,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 2); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 2); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105737,GRIK5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.205814,-0.301942,-0.49541
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.3955% (minimum 99%, Missing); amygdala: 65.4397% (minimum 99%, Missing); basal ganglia: 60.8365% (minimum 99%, Missing); bone marrow: 92.2190% (minimum 99%, Missing); cerebellum: 49.4590% (minimum 99%, Missing); cerebral cortex: 53.9629% (minimum 99%, Missing); choroid plexus: 82.0513% (minimum 99%, Missing); colon: 66.8058% (minimum 97%, Missing); duodenum: 97.8593% (minimum 99%, Missing); esophagus: 95.8084% (minimum 97%, Missing); heart muscle: 86.9565% (minimum 99%, Missing); hippocampal formation: 61.5385% (minimum 99%, Missing); hypothalamus: 67.5105% (minimum 99%, Missing); kidney: 82.4742% (minimum 99%, Missing); lung: 98.4615% (minimum 99%, Missing); midbrain: 78.2396% (minimum 99%, Missing); pancreas: 93.2945% (minimum 99%, Missing); parathyroid gland: 69.8690% (minimum 97%, Missing); pituitary gland: 64.2570% (minimum 99%, Missing); retina: 72.8929% (minimum 99%, Missing); skeletal muscle: 98.4615% (minimum 99%, Missing); small intestine: 90.6516% (minimum 99%, Missing); smooth muscle: 86.9565% (minimum 99%, Missing); spinal cord: 89.8876% (minimum 99%, Missing); stomach: 86.2534% (minimum 97%, Missing); thyroid gland: 74.4186% (minimum 95%, Missing); urinary bladder: 86.9565% (minimum 97%, Missing)",0,80,unavailable,32.7,15.9,11,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 2); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 2); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105737,GRIK5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.205814,-0.301942,-0.49541
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,7.9,5.6,7.5,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); salivary gland: 2.8 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105750,ZNF85,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.1594% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.4962% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.8217% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 70.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.4326% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.3529% (minimum 99%, Baseline (adaptation disabled)); colon: 85.4962% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.5517% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.8217% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.8217% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.4962% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.3529% (minimum 99%, Baseline (adaptation disabled)); liver: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 86.8217% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.8485% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.6387% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.8485% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.3529% (minimum 97%, Baseline (adaptation disabled)); retina: 91.8033% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); skin: 80.5755% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.5821% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.9630% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.3529% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.1905% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.4699% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.2927% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.8930% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 83.5821% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,7.9,5.6,7.5,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); salivary gland: 2.8 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105750,ZNF85,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.35107,-0.303333,-0.403613
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.1594% (minimum 95%, Missing); adrenal gland: 70.0000% (minimum 99%, Missing); amygdala: 85.4962% (minimum 99%, Missing); basal ganglia: 86.8217% (minimum 99%, Missing); bone marrow: 70.0000% (minimum 99%, Missing); cerebellum: 79.4326% (minimum 99%, Missing); cerebral cortex: 82.3529% (minimum 99%, Missing); colon: 85.4962% (minimum 97%, Missing); duodenum: 96.5517% (minimum 99%, Missing); esophagus: 80.0000% (minimum 97%, Missing); heart muscle: 86.8217% (minimum 99%, Missing); hippocampal formation: 86.8217% (minimum 99%, Missing); hypothalamus: 85.4962% (minimum 99%, Missing); kidney: 82.3529% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); lung: 86.8217% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 84.8485% (minimum 99%, Missing); pancreas: 58.6387% (minimum 99%, Missing); parathyroid gland: 84.8485% (minimum 97%, Missing); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 82.3529% (minimum 97%, Missing); retina: 91.8033% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 94.1176% (minimum 99%, Missing); skin: 80.5755% (minimum 95%, Missing); small intestine: 83.5821% (minimum 99%, Missing); smooth muscle: 82.9630% (minimum 99%, Missing); spinal cord: 82.3529% (minimum 99%, Missing); spleen: 76.1905% (minimum 95%, Missing); stomach: 67.4699% (minimum 97%, Missing); thymus: 68.2927% (minimum 95%, Missing); thyroid gland: 59.8930% (minimum 95%, Missing); urinary bladder: 83.5821% (minimum 97%, Missing)",0,5,partial,7.9,5.6,7.5,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); salivary gland: 2.8 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105750,ZNF85,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.35107,-0.303333,-0.403613
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,8,partial,18.1,10.6,12.4,"liver: 18.1 nTPM (vital, limit 2); thymus: 12.4 nTPM (manageable, limit 5); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 2); stomach: 10.4 nTPM (protected, limit 2); tongue: 9.7 nTPM (protected, limit 2); heart muscle: 9.7 nTPM (vital, limit 2); thyroid gland: 9.5 nTPM (manageable, limit 5); rectum: 9.3 nTPM (protected, limit 2); urinary bladder: 9.2 nTPM (protected, limit 2); colon: 8.5 nTPM (protected, limit 2); duodenum: 8.5 nTPM (vital, limit 1); esophagus: 8 nTPM (protected, limit 2); parathyroid gland: 7.8 nTPM (protected, limit 2); pancreas: 7.4 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); skin: 6.6 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 2); lung: 5.6 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105793,GTPBP10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.0681% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.8939% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.1724% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.6575% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.0058% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.7019% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.2210% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.1544% (minimum 99%, Baseline (adaptation disabled)); colon: 56.1856% (minimum 97%, Baseline (adaptation disabled)); duodenum: 56.1856% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.6720% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.9126% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.6486% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.1854% (minimum 99%, Baseline (adaptation disabled)); kidney: 47.3913% (minimum 99%, Baseline (adaptation disabled)); liver: 37.5862% (minimum 99%, Baseline (adaptation disabled)); lung: 66.0606% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.6977% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.7105% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.5628% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.2888% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.2418% (minimum 99%, Baseline (adaptation disabled)); rectum: 53.9604% (minimum 97%, Baseline (adaptation disabled)); retina: 60.8939% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.8810% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 48.0176% (minimum 99%, Baseline (adaptation disabled)); skin: 62.2857% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.2360% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.2360% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.7792% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.2210% (minimum 95%, Baseline (adaptation disabled)); stomach: 51.1737% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.7811% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.4314% (minimum 95%, Baseline (adaptation disabled)); tongue: 52.9126% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.2289% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,18.1,10.6,12.4,"liver: 18.1 nTPM (vital, limit 1); thymus: 12.4 nTPM (manageable, limit 5); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 2); stomach: 10.4 nTPM (protected, limit 2); tongue: 9.7 nTPM (protected, limit 2); heart muscle: 9.7 nTPM (vital, limit 1); thyroid gland: 9.5 nTPM (manageable, limit 5); rectum: 9.3 nTPM (protected, limit 2); urinary bladder: 9.2 nTPM (protected, limit 2); colon: 8.5 nTPM (protected, limit 2); duodenum: 8.5 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); esophagus: 8 nTPM (protected, limit 2); parathyroid gland: 7.8 nTPM (protected, limit 2); pancreas: 7.4 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); adrenal gland: 7 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); skin: 6.6 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); salivary gland: 5.9 nTPM (protected, limit 2); lung: 5.6 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105793,GTPBP10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.482189,-0.463023,-0.614138
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.0681% (minimum 90%, Approved); adrenal gland: 60.8939% (minimum 99%, Missing); amygdala: 75.1724% (minimum 99%, Missing); basal ganglia: 74.6575% (minimum 99%, Missing); bone marrow: 63.0058% (minimum 98%, Approved); cerebellum: 67.7019% (minimum 99%, Missing); cerebral cortex: 60.2210% (minimum 99%, Missing); choroid plexus: 73.1544% (minimum 99%, Missing); colon: 56.1856% (minimum 97%, Missing); duodenum: 56.1856% (minimum 99%, Missing); esophagus: 57.6720% (minimum 97%, Missing); heart muscle: 52.9126% (minimum 98%, Approved); hippocampal formation: 73.6486% (minimum 99%, Missing); hypothalamus: 72.1854% (minimum 99%, Missing); kidney: 47.3913% (minimum 99%, Missing); liver: 37.5862% (minimum 98%, Approved); lung: 66.0606% (minimum 99%, Missing); lymph node: 50.6977% (minimum 97%, Missing); midbrain: 71.7105% (minimum 99%, Missing); pancreas: 59.5628% (minimum 99%, Missing); parathyroid gland: 58.2888% (minimum 97%, Missing); pituitary gland: 71.2418% (minimum 99%, Missing); rectum: 53.9604% (minimum 97%, Missing); retina: 60.8939% (minimum 99%, Missing); salivary gland: 64.8810% (minimum 97%, Missing); skeletal muscle: 48.0176% (minimum 99%, Missing); skin: 62.2857% (minimum 95%, Missing); small intestine: 61.2360% (minimum 99%, Missing); smooth muscle: 61.2360% (minimum 99%, Missing); spinal cord: 70.7792% (minimum 99%, Missing); spleen: 60.2210% (minimum 95%, Missing); stomach: 51.1737% (minimum 97%, Missing); thymus: 46.7811% (minimum 95%, Missing); thyroid gland: 53.4314% (minimum 95%, Missing); tongue: 52.9126% (minimum 97%, Missing); urinary bladder: 54.2289% (minimum 97%, Missing)",0,8,partial,18.1,10.6,12.4,"liver: 18.1 nTPM (vital, limit 2); thymus: 12.4 nTPM (manageable, limit 5); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 2); stomach: 10.4 nTPM (protected, limit 2); tongue: 9.7 nTPM (protected, limit 2); heart muscle: 9.7 nTPM (vital, limit 2); thyroid gland: 9.5 nTPM (manageable, limit 5); rectum: 9.3 nTPM (protected, limit 2); urinary bladder: 9.2 nTPM (protected, limit 2); colon: 8.5 nTPM (protected, limit 2); duodenum: 8.5 nTPM (vital, limit 1); esophagus: 8 nTPM (protected, limit 2); parathyroid gland: 7.8 nTPM (protected, limit 2); pancreas: 7.4 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); skin: 6.6 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 2); lung: 5.6 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105793,GTPBP10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.482189,-0.463023,-0.604138
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,74.1,25.6,49.6,"pancreas: 74.1 nTPM (vital, limit 6); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (manageable, limit 30); adrenal gland: 27.4 nTPM (vital, limit 6); urinary bladder: 25.6 nTPM (protected, limit 12); liver: 20.6 nTPM (vital, limit 6); kidney: 19.8 nTPM (vital, limit 6); lung: 10.9 nTPM (vital, limit 6); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 6); heart muscle: 7.5 nTPM (vital, limit 6); thymus: 6.7 nTPM (manageable, limit 5); hypothalamus: 4.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105825,TFPI2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.9144% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.1252% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.9059% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8231% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8362% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.5885% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.9948% (minimum 99%, Baseline (adaptation disabled)); retina: 94.8658% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,74.1,25.6,49.6,"pancreas: 74.1 nTPM (vital, limit 1); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 2); liver: 20.6 nTPM (vital, limit 1); kidney: 19.8 nTPM (vital, limit 1); lung: 10.9 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); thymus: 6.7 nTPM (manageable, limit 5); stomach: 4.9 nTPM (protected, limit 2); hypothalamus: 4.3 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); choroid plexus: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105825,TFPI2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.000856147,0.00308946,-0.0641148
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 92.5885% (minimum 95%, Enhanced); pituitary gland: 98.9948% (minimum 99%, Missing); retina: 94.8658% (minimum 99%, Missing)",0,4,partial,74.1,25.6,49.6,"pancreas: 74.1 nTPM (vital, limit 6); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (manageable, limit 30); adrenal gland: 27.4 nTPM (vital, limit 6); urinary bladder: 25.6 nTPM (protected, limit 12); liver: 20.6 nTPM (vital, limit 6); kidney: 19.8 nTPM (vital, limit 6); lung: 10.9 nTPM (vital, limit 6); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 6); heart muscle: 7.5 nTPM (vital, limit 6); thymus: 6.7 nTPM (manageable, limit 5); hypothalamus: 4.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105825,TFPI2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0428142,0.0285976,-0.0413425
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,43.1,18.5,16,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 2); thymus: 16 nTPM (manageable, limit 5); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); rectum: 3.7 nTPM (protected, limit 2); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105851,PIK3CG,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.5294% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.0392% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0392% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 10.3950% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.5294% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.2857% (minimum 99%, Baseline (adaptation disabled)); colon: 55.5556% (minimum 97%, Baseline (adaptation disabled)); duodenum: 55.5556% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.6269% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.7576% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.0392% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1538% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 72.4638% (minimum 99%, Baseline (adaptation disabled)); lung: 51.5464% (minimum 99%, Baseline (adaptation disabled)); lymph node: 21.2766% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.3396% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.9091% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.7193% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.1538% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.4713% (minimum 97%, Baseline (adaptation disabled)); retina: 98.0392% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.6452% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.3396% (minimum 99%, Baseline (adaptation disabled)); skin: 87.7193% (minimum 95%, Baseline (adaptation disabled)); small intestine: 54.3478% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.7895% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.9091% (minimum 99%, Baseline (adaptation disabled)); spleen: 31.8471% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.8182% (minimum 97%, Baseline (adaptation disabled)); thymus: 23.8095% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 83.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.7458% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.3478% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,43.1,18.5,16,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 2); thymus: 16 nTPM (manageable, limit 5); spleen: 10.7 nTPM (manageable, limit 5); lung: 4.7 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); rectum: 3.7 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105851,PIK3CG,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.711905,-0.757234,-0.88605
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.5294% (minimum 99%, Missing); amygdala: 98.0392% (minimum 99%, Missing); basal ganglia: 98.0392% (minimum 99%, Missing); bone marrow: 10.3950% (minimum 99%, Missing); cerebral cortex: 73.5294% (minimum 99%, Missing); choroid plexus: 89.2857% (minimum 99%, Missing); colon: 55.5556% (minimum 97%, Missing); duodenum: 55.5556% (minimum 99%, Missing); esophagus: 74.6269% (minimum 80%, Enhanced); heart muscle: 75.7576% (minimum 95%, Enhanced); hippocampal formation: 98.0392% (minimum 99%, Missing); hypothalamus: 96.1538% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 72.4638% (minimum 99%, Missing); lung: 51.5464% (minimum 95%, Enhanced); lymph node: 21.2766% (minimum 97%, Missing); midbrain: 94.3396% (minimum 99%, Missing); pancreas: 90.9091% (minimum 95%, Enhanced); pituitary gland: 96.1538% (minimum 99%, Missing); rectum: 57.4713% (minimum 97%, Missing); retina: 98.0392% (minimum 99%, Missing); skeletal muscle: 94.3396% (minimum 95%, Enhanced); skin: 87.7193% (minimum 95%, Missing); small intestine: 54.3478% (minimum 99%, Missing); smooth muscle: 65.7895% (minimum 95%, Enhanced); spinal cord: 90.9091% (minimum 99%, Missing); spleen: 31.8471% (minimum 95%, Missing); stomach: 56.8182% (minimum 97%, Missing); thymus: 23.8095% (minimum 95%, Missing); thyroid gland: 83.3333% (minimum 95%, Missing); tongue: 84.7458% (minimum 97%, Missing); urinary bladder: 54.3478% (minimum 97%, Missing)",0,3,partial,43.1,18.5,16,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 2); thymus: 16 nTPM (manageable, limit 5); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); rectum: 3.7 nTPM (protected, limit 2); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105851,PIK3CG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.711905,-0.757234,-0.88605
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,7,68.9,1,"parathyroid gland: 68.9 nTPM (protected, limit 4); choroid plexus: 7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; thymus,ENSG00000105877,DNAH11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.9130% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.2264% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.7273% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 42.1488% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.4737% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.7273% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.7273% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.4444% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.2264% (minimum 99%, Baseline (adaptation disabled)); liver: 96.2264% (minimum 99%, Baseline (adaptation disabled)); lung: 82.2581% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0769% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 6.8919% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.0769% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 94.4444% (minimum 99%, Baseline (adaptation disabled)); skin: 87.9310% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.4444% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0769% (minimum 99%, Baseline (adaptation disabled)); thymus: 94.4444% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 83.6066% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,7,68.9,1,"parathyroid gland: 68.9 nTPM (protected, limit 2); choroid plexus: 7 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; thymus,ENSG00000105877,DNAH11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.113934,-0.901081,-0.568512
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.9130% (minimum 98%, Approved); amygdala: 96.2264% (minimum 99%, Missing); basal ganglia: 92.7273% (minimum 99%, Missing); choroid plexus: 42.1488% (minimum 99%, Missing); esophagus: 89.4737% (minimum 95%, Approved); heart muscle: 92.7273% (minimum 98%, Approved); hippocampal formation: 92.7273% (minimum 99%, Missing); hypothalamus: 94.4444% (minimum 99%, Missing); kidney: 96.2264% (minimum 98%, Approved); liver: 96.2264% (minimum 98%, Approved); lung: 82.2581% (minimum 98%, Approved); parathyroid gland: 6.8919% (minimum 95%, Approved); pituitary gland: 98.0769% (minimum 99%, Missing); skeletal muscle: 94.4444% (minimum 98%, Approved); skin: 87.9310% (minimum 90%, Approved); small intestine: 94.4444% (minimum 98%, Approved); spinal cord: 98.0769% (minimum 99%, Missing); thymus: 94.4444% (minimum 95%, Missing); thyroid gland: 83.6066% (minimum 90%, Approved)",0,3,partial,7,68.9,1,"parathyroid gland: 68.9 nTPM (protected, limit 4); choroid plexus: 7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; thymus,ENSG00000105877,DNAH11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0639344,-0.881081,-0.568512
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,34.7,18.1,18,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 2); retina: 13.9 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.8 nTPM (manageable, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 2); urinary bladder: 10.6 nTPM (protected, limit 2); liver: 10.3 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); adipose tissue: 10.3 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 2); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 2); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); salivary gland: 8.4 nTPM (protected, limit 2); adrenal gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105879,CBLL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.3399% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.4789% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.4809% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.0300% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 36.9091% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.8136% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.8902% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.8571% (minimum 99%, Baseline (adaptation disabled)); colon: 64.8562% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.5811% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.7763% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.2185% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.6038% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.9883% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.3502% (minimum 99%, Baseline (adaptation disabled)); liver: 66.3399% (minimum 99%, Baseline (adaptation disabled)); lung: 69.0476% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.4809% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.9967% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.2699% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.5556% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.1208% (minimum 97%, Baseline (adaptation disabled)); retina: 59.3567% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.7317% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 41.0101% (minimum 99%, Baseline (adaptation disabled)); skin: 66.3399% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.2185% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.0379% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.2852% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.5970% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.0026% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.3293% (minimum 95%, Baseline (adaptation disabled)); tongue: 52.8646% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.6958% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,34.7,18.1,18,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 2); retina: 13.9 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.8 nTPM (manageable, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 2); urinary bladder: 10.6 nTPM (protected, limit 2); liver: 10.3 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); adipose tissue: 10.3 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 2); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 2); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); salivary gland: 8.4 nTPM (protected, limit 2); adrenal gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105879,CBLL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.419974,-0.441354,-0.620909
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.3399% (minimum 95%, Missing); adrenal gland: 71.4789% (minimum 99%, Missing); amygdala: 77.4809% (minimum 99%, Missing); basal ganglia: 76.0300% (minimum 99%, Missing); bone marrow: 36.9091% (minimum 99%, Missing); cerebellum: 68.8136% (minimum 99%, Missing); cerebral cortex: 61.8902% (minimum 99%, Missing); choroid plexus: 82.8571% (minimum 99%, Missing); colon: 64.8562% (minimum 97%, Missing); duodenum: 68.5811% (minimum 99%, Missing); esophagus: 66.7763% (minimum 97%, Missing); heart muscle: 67.2185% (minimum 99%, Missing); hippocampal formation: 76.6038% (minimum 99%, Missing); hypothalamus: 78.9883% (minimum 99%, Missing); kidney: 68.3502% (minimum 99%, Missing); liver: 66.3399% (minimum 99%, Missing); lung: 69.0476% (minimum 99%, Missing); lymph node: 58.0000% (minimum 97%, Missing); midbrain: 77.4809% (minimum 99%, Missing); pancreas: 66.9967% (minimum 99%, Missing); parathyroid gland: 62.2699% (minimum 97%, Missing); pituitary gland: 80.5556% (minimum 99%, Missing); rectum: 68.1208% (minimum 97%, Missing); retina: 59.3567% (minimum 99%, Missing); salivary gland: 70.7317% (minimum 97%, Missing); skeletal muscle: 41.0101% (minimum 99%, Missing); skin: 66.3399% (minimum 95%, Missing); small intestine: 67.2185% (minimum 99%, Missing); smooth muscle: 64.0379% (minimum 99%, Missing); spinal cord: 73.2852% (minimum 99%, Missing); spleen: 60.5970% (minimum 95%, Missing); stomach: 70.0000% (minimum 97%, Missing); thymus: 53.0026% (minimum 95%, Missing); thyroid gland: 61.3293% (minimum 95%, Missing); tongue: 52.8646% (minimum 97%, Missing); urinary bladder: 65.6958% (minimum 97%, Missing)",0,3,partial,34.7,18.1,18,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 2); retina: 13.9 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.8 nTPM (manageable, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 2); urinary bladder: 10.6 nTPM (protected, limit 2); liver: 10.3 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); adipose tissue: 10.3 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 2); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 2); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); salivary gland: 8.4 nTPM (protected, limit 2); adrenal gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000105879,CBLL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.419974,-0.441354,-0.620909
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.5,1.6,1.8,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105889,STEAP1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.9677% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.6154% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.4595% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 48.8889% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.6522% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 55.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 28.5714% (minimum 99%, Baseline (adaptation disabled)); colon: 78.5714% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.6522% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.5714% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.4815% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 51.1628% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.7059% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 84.6154% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.8947% (minimum 97%, Baseline (adaptation disabled)); midbrain: 46.8085% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.6522% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.4815% (minimum 97%, Baseline (adaptation disabled)); retina: 88.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 84.6154% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 64.7059% (minimum 99%, Baseline (adaptation disabled)); skin: 84.6154% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 41.5094% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.5714% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.8621% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.5,1.6,1.8,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105889,STEAP1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4,-0.391053,-0.704286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.9677% (minimum 95%, Missing); adrenal gland: 84.6154% (minimum 99%, Missing); amygdala: 59.4595% (minimum 99%, Missing); basal ganglia: 48.8889% (minimum 99%, Missing); cerebellum: 95.6522% (minimum 99%, Missing); cerebral cortex: 55.0000% (minimum 99%, Missing); choroid plexus: 28.5714% (minimum 99%, Missing); colon: 78.5714% (minimum 97%, Missing); duodenum: 95.6522% (minimum 99%, Missing); esophagus: 78.5714% (minimum 97%, Missing); heart muscle: 81.4815% (minimum 99%, Missing); hippocampal formation: 51.1628% (minimum 99%, Missing); hypothalamus: 64.7059% (minimum 99%, Missing); kidney: 91.6667% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 84.6154% (minimum 99%, Missing); lymph node: 57.8947% (minimum 97%, Missing); midbrain: 46.8085% (minimum 99%, Missing); pancreas: 88.0000% (minimum 99%, Missing); parathyroid gland: 95.6522% (minimum 97%, Missing); pituitary gland: 88.0000% (minimum 99%, Missing); rectum: 81.4815% (minimum 97%, Missing); retina: 88.0000% (minimum 99%, Missing); salivary gland: 84.6154% (minimum 97%, Missing); skeletal muscle: 64.7059% (minimum 99%, Missing); skin: 84.6154% (minimum 95%, Missing); small intestine: 88.0000% (minimum 99%, Missing); smooth muscle: 78.5714% (minimum 99%, Missing); spinal cord: 41.5094% (minimum 99%, Missing); spleen: 55.0000% (minimum 95%, Missing); stomach: 88.0000% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 91.6667% (minimum 95%, Missing); tongue: 78.5714% (minimum 97%, Missing); urinary bladder: 75.8621% (minimum 97%, Missing)",0,80,unavailable,5.5,1.6,1.8,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105889,STEAP1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4,-0.391053,-0.704286
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,12,partial,11.1,7.9,4.7,"choroid plexus: 11.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105948,IFT56,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.2611% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.0359% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.7285% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.1635% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.0932% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.3871% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.7285% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 55.2419% (minimum 99%, Baseline (adaptation disabled)); colon: 90.1316% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.1389% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.3871% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.1316% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.9610% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.1635% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.2747% (minimum 99%, Baseline (adaptation disabled)); liver: 92.5676% (minimum 99%, Baseline (adaptation disabled)); lung: 81.0651% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.8205% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.5676% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.5425% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.4259% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 79.1908% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.5425% (minimum 97%, Baseline (adaptation disabled)); retina: 75.2747% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.3871% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.1973% (minimum 99%, Baseline (adaptation disabled)); skin: 88.3871% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.1973% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.0303% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.5676% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.9610% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.1316% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.0932% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 74.4565% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.1316% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.0932% (minimum 97%, Baseline (adaptation disabled))",0,12,partial,11.1,7.9,4.7,"choroid plexus: 11.1 nTPM (vital, limit 1); parathyroid gland: 7.9 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105948,IFT56,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.205435,-0.335741,-0.437581
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 82.0359% (minimum 95%, Enhanced); amygdala: 90.7285% (minimum 99%, Missing); basal ganglia: 86.1635% (minimum 99%, Missing); bone marrow: 85.0932% (minimum 95%, Enhanced); cerebellum: 88.3871% (minimum 95%, Enhanced); cerebral cortex: 90.7285% (minimum 99%, Missing); choroid plexus: 55.2419% (minimum 99%, Missing); colon: 90.1316% (minimum 97%, Missing); duodenum: 95.1389% (minimum 99%, Missing); heart muscle: 90.1316% (minimum 95%, Enhanced); hippocampal formation: 88.9610% (minimum 99%, Missing); hypothalamus: 86.1635% (minimum 99%, Missing); kidney: 75.2747% (minimum 95%, Enhanced); liver: 92.5676% (minimum 95%, Enhanced); lung: 81.0651% (minimum 95%, Enhanced); midbrain: 92.5676% (minimum 99%, Missing); pancreas: 89.5425% (minimum 95%, Enhanced); parathyroid gland: 63.4259% (minimum 80%, Enhanced); pituitary gland: 79.1908% (minimum 99%, Missing); rectum: 89.5425% (minimum 97%, Missing); retina: 75.2747% (minimum 99%, Missing); skeletal muscle: 93.1973% (minimum 95%, Enhanced); small intestine: 93.1973% (minimum 99%, Missing); smooth muscle: 83.0303% (minimum 95%, Enhanced); spinal cord: 92.5676% (minimum 99%, Missing); thymus: 85.0932% (minimum 95%, Missing); tongue: 90.1316% (minimum 97%, Missing)",0,12,partial,11.1,7.9,4.7,"choroid plexus: 11.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105948,IFT56,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0990683,-0.165741,-0.437581
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,9,partial,3.4,2.9,2.4,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105982,RNF32,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8441% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.9350% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.9350% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.1993% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1697% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.8801% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9933% (minimum 99%, Baseline (adaptation disabled)); colon: 96.8801% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.3597% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.9933% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.2480% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.2480% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.5630% (minimum 99%, Baseline (adaptation disabled)); liver: 98.1697% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5207% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.7213% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.4052% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7213% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.3597% (minimum 99%, Baseline (adaptation disabled)); retina: 95.6240% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.1697% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.8441% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.5513% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.3150% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,3.4,2.9,2.4,"spinal cord: 3.4 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105982,RNF32,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0109121,-0.0168498,-0.0444872
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.9350% (minimum 99%, Missing); basal ganglia: 95.9350% (minimum 99%, Missing); choroid plexus: 98.9933% (minimum 99%, Missing); colon: 96.8801% (minimum 97%, Missing); duodenum: 97.3597% (minimum 99%, Missing); hippocampal formation: 96.2480% (minimum 99%, Missing); hypothalamus: 96.2480% (minimum 99%, Missing); midbrain: 96.4052% (minimum 99%, Missing); pituitary gland: 97.3597% (minimum 99%, Missing); retina: 95.6240% (minimum 99%, Missing); small intestine: 97.8441% (minimum 99%, Missing); spinal cord: 94.5513% (minimum 99%, Missing)",0,9,partial,3.4,2.9,2.4,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000105982,RNF32,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0316972,-0.00119869,-0.0444872
True,compatible,,True,True,False,,0,80,unavailable,0.7,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106013,ANKRD7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.7,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106013,ANKRD7,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0490426,0.0297605,0.00916218
True,compatible,,True,True,True,,0,80,unavailable,0.7,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106013,ANKRD7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0490426,0.0297605,0.00916218
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,11.8,4.6,6.5,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (manageable, limit 5); smooth muscle: 5.7 nTPM (vital, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); cerebral cortex: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 2); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000106125,MINDY4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.4286% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.5102% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.4016% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.4966% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.2222% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.5000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.2857% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 48.4716% (minimum 99%, Baseline (adaptation disabled)); colon: 71.6129% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.5161% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.8561% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.1538% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.7328% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.0219% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.8113% (minimum 99%, Baseline (adaptation disabled)); liver: 84.0909% (minimum 99%, Baseline (adaptation disabled)); lung: 54.6798% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.2439% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.8358% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.0833% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.7006% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.2727% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.7328% (minimum 97%, Baseline (adaptation disabled)); retina: 84.7328% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.7234% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.4586% (minimum 99%, Baseline (adaptation disabled)); skin: 78.1690% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.0909% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.0714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.9836% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.9836% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.1690% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.9836% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 63.0682% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.0833% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.5490% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,11.8,4.6,6.5,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (manageable, limit 5); adipose tissue: 6.4 nTPM (manageable, limit 5); smooth muscle: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); cerebral cortex: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000106125,MINDY4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.319318,-0.262994,-0.505284
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.4286% (minimum 90%, Approved); adrenal gland: 75.5102% (minimum 99%, Missing); amygdala: 87.4016% (minimum 99%, Missing); basal ganglia: 74.4966% (minimum 99%, Missing); bone marrow: 82.2222% (minimum 98%, Approved); cerebellum: 92.5000% (minimum 99%, Missing); cerebral cortex: 79.2857% (minimum 99%, Missing); choroid plexus: 48.4716% (minimum 99%, Missing); colon: 71.6129% (minimum 97%, Missing); duodenum: 89.5161% (minimum 99%, Missing); esophagus: 79.8561% (minimum 97%, Missing); heart muscle: 71.1538% (minimum 99%, Missing); hippocampal formation: 84.7328% (minimum 99%, Missing); hypothalamus: 81.0219% (minimum 99%, Missing); kidney: 69.8113% (minimum 99%, Missing); liver: 84.0909% (minimum 99%, Missing); lung: 54.6798% (minimum 99%, Missing); lymph node: 90.2439% (minimum 97%, Missing); midbrain: 82.8358% (minimum 99%, Missing); pancreas: 77.0833% (minimum 99%, Missing); parathyroid gland: 70.7006% (minimum 97%, Missing); pituitary gland: 67.2727% (minimum 99%, Missing); rectum: 84.7328% (minimum 97%, Missing); retina: 84.7328% (minimum 99%, Missing); salivary gland: 78.7234% (minimum 97%, Missing); skeletal muscle: 83.4586% (minimum 98%, Approved); skin: 78.1690% (minimum 95%, Missing); small intestine: 84.0909% (minimum 99%, Missing); smooth muscle: 66.0714% (minimum 98%, Approved); spinal cord: 90.9836% (minimum 99%, Missing); stomach: 78.1690% (minimum 97%, Missing); thymus: 90.9836% (minimum 95%, Missing); thyroid gland: 63.0682% (minimum 95%, Missing); tongue: 77.0833% (minimum 97%, Missing); urinary bladder: 72.5490% (minimum 97%, Missing)",0,2,partial,11.8,4.6,6.5,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (manageable, limit 5); smooth muscle: 5.7 nTPM (vital, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); cerebral cortex: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 2); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000106125,MINDY4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.319318,-0.262994,-0.505284
True,compatible,,True,True,False,,0,1,partial,0.4,0,0,,,53,not_established,not_triggered,,,ENSG00000106304,SPAM1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 97.6879% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.2558% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2558% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.4,0,0,,,53,not_established,not_triggered,,,ENSG00000106304,SPAM1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0131214
True,compatible,,True,True,True,,0,1,partial,0.4,0,0,,,53,not_established,not_triggered,,,ENSG00000106304,SPAM1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0.5,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000106328,FSCN3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.5,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000106328,FSCN3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0468976,0.0289637,0.00484004
True,compatible,,True,True,True,,0,1,partial,0.5,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000106328,FSCN3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00896373
True,compatible,,True,True,False,,0,3,partial,1,1.2,1.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106336,FBXO24,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 98.7500% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.9975% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7500% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1,1.2,1.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106336,FBXO24,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0338107,0.0150374,-0.0025
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 98.9975% (minimum 99%, Missing); retina: 98.7500% (minimum 99%, Missing)",0,3,partial,1,1.2,1.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106336,FBXO24,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0474747,0.0262169,-0.0025
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000106410,NOBOX,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000106410,NOBOX,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000106410,NOBOX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,308.9,115.4,133.5,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); thymus: 133.5 nTPM (manageable, limit 5); bone marrow: 118.5 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 2); heart muscle: 115.4 nTPM (vital, limit 1); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 2); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 2); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 2); adipose tissue: 97.5 nTPM (manageable, limit 5); small intestine: 93.9 nTPM (vital, limit 1); spleen: 91.9 nTPM (manageable, limit 5); urinary bladder: 88.9 nTPM (protected, limit 2); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 2); skin: 84.2 nTPM (manageable, limit 5); rectum: 83.7 nTPM (protected, limit 2); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); salivary gland: 73.7 nTPM (protected, limit 2); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 2); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (manageable, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000106588,PSMA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.7682% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 46.7797% (minimum 99%, Baseline (adaptation disabled)); amygdala: 60.2244% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 59.4096% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 44.9093% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.5360% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.0548% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 48.0119% (minimum 99%, Baseline (adaptation disabled)); colon: 52.3861% (minimum 97%, Baseline (adaptation disabled)); duodenum: 48.8866% (minimum 99%, Baseline (adaptation disabled)); esophagus: 47.4693% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 45.5660% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 62.2423% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.7647% (minimum 99%, Baseline (adaptation disabled)); kidney: 45.9344% (minimum 99%, Baseline (adaptation disabled)); liver: 23.8224% (minimum 99%, Baseline (adaptation disabled)); lung: 53.6965% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.4371% (minimum 97%, Baseline (adaptation disabled)); midbrain: 57.2614% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.2445% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.7234% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 60.8696% (minimum 99%, Baseline (adaptation disabled)); rectum: 53.5774% (minimum 97%, Baseline (adaptation disabled)); retina: 70.5109% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.7234% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 30.5599% (minimum 99%, Baseline (adaptation disabled)); skin: 53.4292% (minimum 95%, Baseline (adaptation disabled)); small intestine: 50.7087% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.9628% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 55.0741% (minimum 99%, Baseline (adaptation disabled)); spleen: 51.2467% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.7141% (minimum 97%, Baseline (adaptation disabled)); thymus: 41.9817% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.6296% (minimum 95%, Baseline (adaptation disabled)); tongue: 45.5660% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.0755% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,308.9,115.4,133.5,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); thymus: 133.5 nTPM (manageable, limit 5); bone marrow: 118.5 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 2); heart muscle: 115.4 nTPM (vital, limit 1); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 2); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 2); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 2); adipose tissue: 97.5 nTPM (manageable, limit 5); small intestine: 93.9 nTPM (vital, limit 1); spleen: 91.9 nTPM (manageable, limit 5); urinary bladder: 88.9 nTPM (protected, limit 2); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 2); skin: 84.2 nTPM (manageable, limit 5); rectum: 83.7 nTPM (protected, limit 2); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); salivary gland: 73.7 nTPM (protected, limit 2); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 2); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (manageable, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000106588,PSMA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.530183,-0.51434,-0.751776
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.7682% (minimum 95%, Uncertain); adrenal gland: 46.7797% (minimum 99%, Missing); amygdala: 60.2244% (minimum 99%, Missing); basal ganglia: 59.4096% (minimum 99%, Missing); bone marrow: 44.9093% (minimum 99%, Missing); cerebellum: 65.5360% (minimum 99%, Missing); cerebral cortex: 63.0548% (minimum 99%, Missing); choroid plexus: 48.0119% (minimum 99%, Missing); colon: 52.3861% (minimum 97%, Missing); duodenum: 48.8866% (minimum 99%, Missing); esophagus: 47.4693% (minimum 97%, Missing); heart muscle: 45.5660% (minimum 99%, Missing); hippocampal formation: 62.2423% (minimum 99%, Missing); hypothalamus: 61.7647% (minimum 99%, Missing); kidney: 45.9344% (minimum 99%, Missing); liver: 23.8224% (minimum 99%, Missing); lung: 53.6965% (minimum 99%, Missing); lymph node: 49.4371% (minimum 97%, Missing); midbrain: 57.2614% (minimum 99%, Missing); pancreas: 52.2445% (minimum 99%, Missing); parathyroid gland: 58.7234% (minimum 97%, Missing); pituitary gland: 60.8696% (minimum 99%, Missing); rectum: 53.5774% (minimum 97%, Missing); retina: 70.5109% (minimum 99%, Missing); salivary gland: 56.7234% (minimum 97%, Missing); skeletal muscle: 30.5599% (minimum 99%, Uncertain); skin: 53.4292% (minimum 95%, Missing); small intestine: 50.7087% (minimum 99%, Missing); smooth muscle: 59.9628% (minimum 99%, Uncertain); spinal cord: 55.0741% (minimum 99%, Missing); spleen: 51.2467% (minimum 95%, Missing); stomach: 48.7141% (minimum 97%, Missing); thymus: 41.9817% (minimum 95%, Missing); thyroid gland: 59.6296% (minimum 95%, Missing); tongue: 45.5660% (minimum 97%, Missing); urinary bladder: 52.0755% (minimum 97%, Missing)",0,3,partial,308.9,115.4,133.5,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); thymus: 133.5 nTPM (manageable, limit 5); bone marrow: 118.5 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 2); heart muscle: 115.4 nTPM (vital, limit 1); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 2); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 2); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 2); adipose tissue: 97.5 nTPM (manageable, limit 5); small intestine: 93.9 nTPM (vital, limit 1); spleen: 91.9 nTPM (manageable, limit 5); urinary bladder: 88.9 nTPM (protected, limit 2); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 2); skin: 84.2 nTPM (manageable, limit 5); rectum: 83.7 nTPM (protected, limit 2); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); salivary gland: 73.7 nTPM (protected, limit 2); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 2); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (manageable, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000106588,PSMA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.530183,-0.51434,-0.751776
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,15.5,6,4.5,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); salivary gland: 5.3 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); liver: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106638,TBL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 81.7391% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.4829% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.6108% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.0693% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.5323% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.4315% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.3846% (minimum 99%, Baseline (adaptation disabled)); colon: 82.4561% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.1569% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.3419% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.4545% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.0693% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.5323% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.5556% (minimum 99%, Baseline (adaptation disabled)); liver: 80.6867% (minimum 99%, Baseline (adaptation disabled)); lung: 82.4561% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.0693% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.6108% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.8105% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.5238% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.6359% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.7073% (minimum 97%, Baseline (adaptation disabled)); retina: 94.4724% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.0083% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.6108% (minimum 99%, Baseline (adaptation disabled)); skin: 80.6867% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.8194% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.5323% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.0693% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.2385% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.8065% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 81.3853% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.9072% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.2385% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,15.5,6,4.5,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); salivary gland: 5.3 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); liver: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106638,TBL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.143133,-0.211935,-0.441895
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 81.7391% (minimum 95%, Missing); adrenal gland: 71.4829% (minimum 99%, Missing); amygdala: 92.6108% (minimum 99%, Missing); basal ganglia: 93.0693% (minimum 99%, Missing); bone marrow: 93.5323% (minimum 99%, Missing); cerebellum: 95.4315% (minimum 99%, Missing); cerebral cortex: 94.0000% (minimum 99%, Missing); choroid plexus: 90.3846% (minimum 99%, Missing); colon: 82.4561% (minimum 97%, Missing); duodenum: 92.1569% (minimum 99%, Missing); esophagus: 80.3419% (minimum 97%, Missing); heart muscle: 85.4545% (minimum 99%, Missing); hippocampal formation: 93.0693% (minimum 99%, Missing); hypothalamus: 93.5323% (minimum 99%, Missing); kidney: 83.5556% (minimum 99%, Missing); liver: 80.6867% (minimum 99%, Missing); lung: 82.4561% (minimum 99%, Missing); lymph node: 93.0693% (minimum 97%, Missing); midbrain: 92.6108% (minimum 99%, Missing); pancreas: 54.8105% (minimum 99%, Missing); parathyroid gland: 89.5238% (minimum 97%, Missing); pituitary gland: 86.6359% (minimum 99%, Missing); rectum: 91.7073% (minimum 97%, Missing); retina: 94.4724% (minimum 99%, Missing); salivary gland: 78.0083% (minimum 97%, Missing); skeletal muscle: 92.6108% (minimum 99%, Missing); skin: 80.6867% (minimum 95%, Missing); small intestine: 82.8194% (minimum 99%, Missing); smooth muscle: 93.5323% (minimum 99%, Missing); spinal cord: 93.0693% (minimum 99%, Missing); spleen: 86.2385% (minimum 95%, Missing); stomach: 75.8065% (minimum 97%, Missing); thyroid gland: 81.3853% (minimum 95%, Missing); tongue: 96.9072% (minimum 97%, Missing); urinary bladder: 86.2385% (minimum 97%, Missing)",0,80,unavailable,15.5,6,4.5,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); salivary gland: 5.3 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); liver: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106638,TBL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.143133,-0.211935,-0.441895
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),52,not_established,not_triggered,,,ENSG00000106648,GALNTL5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 92.1053% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.4545% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.2353% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.7500% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),52,not_established,not_triggered,,,ENSG00000106648,GALNTL5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.107647
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 92.1053% (minimum 99%, Missing); basal ganglia: 95.4545% (minimum 99%, Missing); cerebral cortex: 88.2353% (minimum 99%, Missing); hippocampal formation: 93.7500% (minimum 99%, Missing)",0,2,partial,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),52,not_established,not_triggered,,,ENSG00000106648,GALNTL5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.107647
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,68.1,17.6,26.7,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); thymus: 26.7 nTPM (manageable, limit 5); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); skin: 19.4 nTPM (manageable, limit 5); spleen: 18 nTPM (manageable, limit 5); urinary bladder: 17.6 nTPM (protected, limit 2); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 2); esophagus: 15.4 nTPM (protected, limit 2); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 2); parathyroid gland: 10.2 nTPM (protected, limit 2); rectum: 10.1 nTPM (protected, limit 2); thyroid gland: 9.9 nTPM (manageable, limit 5); salivary gland: 9.7 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106829,TLE4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.5966% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.6608% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.9175% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.8585% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.0253% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.2759% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.1282% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.1608% (minimum 99%, Baseline (adaptation disabled)); colon: 91.0864% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3397% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.4317% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.2510% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.2039% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.2194% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.8756% (minimum 99%, Baseline (adaptation disabled)); liver: 94.5998% (minimum 99%, Baseline (adaptation disabled)); lung: 89.0200% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.4317% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.5843% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.1459% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.5817% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.6743% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.6654% (minimum 97%, Baseline (adaptation disabled)); retina: 80.1471% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.0019% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.4784% (minimum 99%, Baseline (adaptation disabled)); skin: 83.4894% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.9175% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.6676% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.5808% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.4961% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.2988% (minimum 97%, Baseline (adaptation disabled)); thymus: 78.6058% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.8333% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.3315% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.7882% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,68.1,17.6,26.7,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); thymus: 26.7 nTPM (manageable, limit 5); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); skin: 19.4 nTPM (manageable, limit 5); spleen: 18 nTPM (manageable, limit 5); urinary bladder: 17.6 nTPM (protected, limit 2); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 2); esophagus: 15.4 nTPM (protected, limit 2); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 2); parathyroid gland: 10.2 nTPM (protected, limit 2); rectum: 10.1 nTPM (protected, limit 2); thyroid gland: 9.9 nTPM (manageable, limit 5); salivary gland: 9.7 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106829,TLE4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.163942,-0.122118,-0.399747
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.5966% (minimum 95%, Missing); adrenal gland: 86.6608% (minimum 99%, Missing); amygdala: 89.9175% (minimum 99%, Missing); basal ganglia: 78.8585% (minimum 99%, Missing); bone marrow: 59.0253% (minimum 99%, Missing); cerebellum: 81.2759% (minimum 99%, Missing); cerebral cortex: 86.1282% (minimum 99%, Missing); choroid plexus: 82.1608% (minimum 99%, Missing); colon: 91.0864% (minimum 97%, Missing); duodenum: 93.3397% (minimum 99%, Missing); esophagus: 86.4317% (minimum 97%, Missing); heart muscle: 93.2510% (minimum 99%, Missing); hippocampal formation: 86.2039% (minimum 99%, Missing); hypothalamus: 88.2194% (minimum 99%, Missing); kidney: 93.8756% (minimum 99%, Missing); liver: 94.5998% (minimum 99%, Missing); lung: 89.0200% (minimum 99%, Missing); lymph node: 86.4317% (minimum 97%, Missing); midbrain: 86.5843% (minimum 99%, Missing); pancreas: 94.1459% (minimum 99%, Missing); parathyroid gland: 90.5817% (minimum 97%, Missing); pituitary gland: 80.6743% (minimum 99%, Missing); rectum: 90.6654% (minimum 97%, Missing); retina: 80.1471% (minimum 99%, Missing); salivary gland: 91.0019% (minimum 97%, Missing); skeletal muscle: 81.4784% (minimum 99%, Missing); skin: 83.4894% (minimum 95%, Missing); small intestine: 89.9175% (minimum 99%, Missing); smooth muscle: 87.6676% (minimum 99%, Missing); spinal cord: 76.5808% (minimum 99%, Missing); spleen: 84.4961% (minimum 95%, Missing); stomach: 88.2988% (minimum 97%, Missing); thymus: 78.6058% (minimum 95%, Missing); thyroid gland: 90.8333% (minimum 95%, Missing); tongue: 90.3315% (minimum 97%, Missing); urinary bladder: 84.7882% (minimum 97%, Missing)",0,80,unavailable,68.1,17.6,26.7,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); thymus: 26.7 nTPM (manageable, limit 5); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); skin: 19.4 nTPM (manageable, limit 5); spleen: 18 nTPM (manageable, limit 5); urinary bladder: 17.6 nTPM (protected, limit 2); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 2); esophagus: 15.4 nTPM (protected, limit 2); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 2); parathyroid gland: 10.2 nTPM (protected, limit 2); rectum: 10.1 nTPM (protected, limit 2); thyroid gland: 9.9 nTPM (manageable, limit 5); salivary gland: 9.7 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000106829,TLE4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.163942,-0.122118,-0.399747
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,17,16.9,14.4,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 2); tongue: 15.1 nTPM (protected, limit 2); thymus: 14.4 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skin: 13.1 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); spleen: 11.5 nTPM (manageable, limit 5); salivary gland: 11 nTPM (protected, limit 2); esophagus: 11 nTPM (protected, limit 2); thyroid gland: 10.9 nTPM (manageable, limit 5); urinary bladder: 10.6 nTPM (protected, limit 2); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 2); parathyroid gland: 8.6 nTPM (protected, limit 2); colon: 8.1 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); kidney: 7.2 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000107036,RIC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7619% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.3462% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.1429% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.8571% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 51.3011% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.3171% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.2513% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.3103% (minimum 99%, Baseline (adaptation disabled)); colon: 63.0137% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.7234% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.6452% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.3171% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.7018% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.1325% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.7143% (minimum 99%, Baseline (adaptation disabled)); liver: 58.9744% (minimum 99%, Baseline (adaptation disabled)); lung: 58.4746% (minimum 99%, Baseline (adaptation disabled)); lymph node: 44.9511% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.6568% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.5000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.6071% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 74.5946% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.2620% (minimum 97%, Baseline (adaptation disabled)); retina: 65.7143% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.6452% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 44.8052% (minimum 99%, Baseline (adaptation disabled)); skin: 51.3011% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.2620% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 51.8797% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.0950% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.5455% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.1860% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.9362% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.8704% (minimum 95%, Baseline (adaptation disabled)); tongue: 47.7509% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.5574% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,17,16.9,14.4,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 2); tongue: 15.1 nTPM (protected, limit 2); thymus: 14.4 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skin: 13.1 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); spleen: 11.5 nTPM (manageable, limit 5); adipose tissue: 11.4 nTPM (manageable, limit 5); esophagus: 11 nTPM (protected, limit 2); salivary gland: 11 nTPM (protected, limit 2); thyroid gland: 10.9 nTPM (manageable, limit 5); urinary bladder: 10.6 nTPM (protected, limit 2); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 2); parathyroid gland: 8.6 nTPM (protected, limit 2); colon: 8.1 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); retina: 7.2 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000107036,RIC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.460638,-0.520489,-0.541948
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7619% (minimum 80%, Supported); adrenal gland: 66.3462% (minimum 99%, Missing); amygdala: 82.1429% (minimum 99%, Missing); basal ganglia: 78.8571% (minimum 99%, Missing); bone marrow: 51.3011% (minimum 99%, Missing); cerebellum: 67.3171% (minimum 99%, Missing); cerebral cortex: 72.2513% (minimum 99%, Missing); choroid plexus: 79.3103% (minimum 99%, Missing); colon: 63.0137% (minimum 97%, Missing); duodenum: 58.7234% (minimum 99%, Missing); esophagus: 55.6452% (minimum 97%, Missing); heart muscle: 67.3171% (minimum 99%, Missing); hippocampal formation: 80.7018% (minimum 99%, Missing); hypothalamus: 83.1325% (minimum 99%, Missing); kidney: 65.7143% (minimum 99%, Missing); liver: 58.9744% (minimum 99%, Missing); lung: 58.4746% (minimum 99%, Missing); lymph node: 44.9511% (minimum 97%, Missing); midbrain: 81.6568% (minimum 99%, Missing); pancreas: 57.5000% (minimum 99%, Missing); parathyroid gland: 61.6071% (minimum 97%, Missing); pituitary gland: 74.5946% (minimum 99%, Missing); rectum: 60.2620% (minimum 97%, Missing); retina: 65.7143% (minimum 99%, Missing); salivary gland: 55.6452% (minimum 97%, Missing); skeletal muscle: 44.8052% (minimum 99%, Missing); skin: 51.3011% (minimum 95%, Missing); small intestine: 60.2620% (minimum 99%, Missing); smooth muscle: 51.8797% (minimum 99%, Missing); spinal cord: 77.0950% (minimum 99%, Missing); spleen: 54.5455% (minimum 95%, Missing); stomach: 64.1860% (minimum 97%, Missing); thymus: 48.9362% (minimum 95%, Missing); thyroid gland: 55.8704% (minimum 95%, Missing); tongue: 47.7509% (minimum 97%, Missing); urinary bladder: 56.5574% (minimum 97%, Missing)",0,7,partial,17,16.9,14.4,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 2); tongue: 15.1 nTPM (protected, limit 2); thymus: 14.4 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skin: 13.1 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); spleen: 11.5 nTPM (manageable, limit 5); salivary gland: 11 nTPM (protected, limit 2); esophagus: 11 nTPM (protected, limit 2); thyroid gland: 10.9 nTPM (manageable, limit 5); urinary bladder: 10.6 nTPM (protected, limit 2); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 2); parathyroid gland: 8.6 nTPM (protected, limit 2); colon: 8.1 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); kidney: 7.2 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000107036,RIC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.460638,-0.520489,-0.541948
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,38.3,18.7,23,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); thymus: 23 nTPM (manageable, limit 5); lymph node: 18.7 nTPM (protected, limit 2); parathyroid gland: 17.2 nTPM (protected, limit 2); choroid plexus: 16.3 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 2); pancreas: 15.6 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 2); skin: 14.7 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); spleen: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 2); thyroid gland: 13 nTPM (manageable, limit 5); duodenum: 12.7 nTPM (vital, limit 1); pituitary gland: 11.5 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 2); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); urinary bladder: 9.9 nTPM (protected, limit 2); adipose tissue: 9.7 nTPM (manageable, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000107077,KDM4C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 55.5024% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.0435% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.4167% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 28.0872% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 23.2465% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.4167% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 41.5771% (minimum 99%, Baseline (adaptation disabled)); colon: 46.5863% (minimum 97%, Baseline (adaptation disabled)); duodenum: 47.7366% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.9535% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.7330% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 59.1837% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 57.7114% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 52.0179% (minimum 99%, Baseline (adaptation disabled)); lung: 52.9680% (minimum 99%, Baseline (adaptation disabled)); lymph node: 38.2838% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.7021% (minimum 99%, Baseline (adaptation disabled)); pancreas: 42.6471% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 40.2778% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 50.2165% (minimum 99%, Baseline (adaptation disabled)); rectum: 42.6471% (minimum 97%, Baseline (adaptation disabled)); retina: 29.2929% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.6550% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 59.1837% (minimum 99%, Baseline (adaptation disabled)); skin: 44.1065% (minimum 95%, Baseline (adaptation disabled)); small intestine: 45.3125% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 52.7273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 54.7170% (minimum 99%, Baseline (adaptation disabled)); spleen: 46.2151% (minimum 95%, Baseline (adaptation disabled)); stomach: 44.1065% (minimum 97%, Baseline (adaptation disabled)); thymus: 33.5260% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 47.1545% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.9535% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,38.3,18.7,23,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); thymus: 23 nTPM (manageable, limit 5); lymph node: 18.7 nTPM (protected, limit 2); parathyroid gland: 17.2 nTPM (protected, limit 2); choroid plexus: 16.3 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 2); pancreas: 15.6 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 2); skin: 14.7 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); spleen: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 2); thyroid gland: 13 nTPM (manageable, limit 5); duodenum: 12.7 nTPM (vital, limit 1); pituitary gland: 11.5 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 2); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); urinary bladder: 9.9 nTPM (protected, limit 2); adipose tissue: 9.7 nTPM (manageable, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000107077,KDM4C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.61474,-0.587162,-0.757535
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 95%, Missing); adrenal gland: 55.5024% (minimum 99%, Missing); amygdala: 63.0435% (minimum 99%, Missing); basal ganglia: 60.4167% (minimum 99%, Missing); bone marrow: 28.0872% (minimum 99%, Missing); cerebellum: 23.2465% (minimum 99%, Missing); cerebral cortex: 60.4167% (minimum 99%, Missing); choroid plexus: 41.5771% (minimum 99%, Missing); colon: 46.5863% (minimum 97%, Missing); duodenum: 47.7366% (minimum 99%, Missing); esophagus: 53.9535% (minimum 97%, Missing); heart muscle: 60.7330% (minimum 99%, Missing); hippocampal formation: 59.1837% (minimum 99%, Missing); hypothalamus: 57.7114% (minimum 99%, Missing); kidney: 58.0000% (minimum 99%, Missing); liver: 52.0179% (minimum 99%, Missing); lung: 52.9680% (minimum 99%, Missing); lymph node: 38.2838% (minimum 97%, Missing); midbrain: 61.7021% (minimum 99%, Missing); pancreas: 42.6471% (minimum 99%, Missing); parathyroid gland: 40.2778% (minimum 97%, Missing); pituitary gland: 50.2165% (minimum 99%, Missing); rectum: 42.6471% (minimum 97%, Missing); retina: 29.2929% (minimum 99%, Missing); salivary gland: 50.6550% (minimum 97%, Missing); skeletal muscle: 59.1837% (minimum 99%, Missing); skin: 44.1065% (minimum 95%, Missing); small intestine: 45.3125% (minimum 99%, Missing); smooth muscle: 52.7273% (minimum 99%, Missing); spinal cord: 54.7170% (minimum 99%, Missing); spleen: 46.2151% (minimum 95%, Missing); stomach: 44.1065% (minimum 97%, Missing); thymus: 33.5260% (minimum 95%, Missing); thyroid gland: 47.1545% (minimum 95%, Missing); tongue: 66.6667% (minimum 97%, Missing); urinary bladder: 53.9535% (minimum 97%, Missing)",0,80,unavailable,38.3,18.7,23,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); thymus: 23 nTPM (manageable, limit 5); lymph node: 18.7 nTPM (protected, limit 2); parathyroid gland: 17.2 nTPM (protected, limit 2); choroid plexus: 16.3 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 2); pancreas: 15.6 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 2); skin: 14.7 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); spleen: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 2); thyroid gland: 13 nTPM (manageable, limit 5); duodenum: 12.7 nTPM (vital, limit 1); pituitary gland: 11.5 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 2); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); urinary bladder: 9.9 nTPM (protected, limit 2); adipose tissue: 9.7 nTPM (manageable, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000107077,KDM4C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.61474,-0.587162,-0.757535
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,24.2,0.5,0.5,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000107105,ELAVL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.9838% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.6000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.8925% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.8180% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.2774% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.1046% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.2441% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8180% (minimum 99%, Baseline (adaptation disabled)); midbrain: 70.8475% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.6636% (minimum 99%, Baseline (adaptation disabled)); retina: 89.6996% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.7220% (minimum 99%, Baseline (adaptation disabled))",0,7,partial,24.2,0.5,0.5,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000107105,ELAVL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0381797,0.0181797,-0.356667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 83.6000% (minimum 99%, Missing); basal ganglia: 89.8925% (minimum 99%, Missing); cerebellum: 76.2774% (minimum 99%, Missing); cerebral cortex: 63.3333% (minimum 99%, Missing); hippocampal formation: 84.1046% (minimum 99%, Missing); hypothalamus: 66.2441% (minimum 99%, Missing); kidney: 98.8180% (minimum 99%, Missing); midbrain: 70.8475% (minimum 99%, Missing); pituitary gland: 97.6636% (minimum 99%, Missing); retina: 89.6996% (minimum 99%, Missing); spinal cord: 93.7220% (minimum 99%, Missing)",0,7,partial,24.2,0.5,0.5,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000107105,ELAVL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,0.0181797,-0.356667
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,19.4,2.3,0.9,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); parathyroid gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000107518,ATRNL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.6154% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.1850% (minimum 99%, Baseline (adaptation disabled)); amygdala: 66.1290% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.0983% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.4412% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 38.8013% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.3529% (minimum 99%, Baseline (adaptation disabled)); colon: 84.2466% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.6190% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.0938% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.2340% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.3979% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.4601% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 89.1304% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.8504% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.6735% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.4412% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.4167% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.7151% (minimum 99%, Baseline (adaptation disabled)); retina: 66.8478% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.1818% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.0000% (minimum 99%, Baseline (adaptation disabled)); small intestine: 93.8931% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.7151% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.1304% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.8504% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.1818% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.3488% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,19.4,2.3,0.9,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); parathyroid gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000107518,ATRNL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0181818,-0.127534,-0.601987
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.6154% (minimum 95%, Missing); adrenal gland: 54.1850% (minimum 99%, Missing); amygdala: 66.1290% (minimum 99%, Missing); basal ganglia: 71.0983% (minimum 99%, Missing); cerebellum: 90.4412% (minimum 99%, Missing); cerebral cortex: 38.8013% (minimum 99%, Missing); choroid plexus: 72.3529% (minimum 99%, Missing); colon: 84.2466% (minimum 97%, Missing); duodenum: 97.6190% (minimum 99%, Missing); esophagus: 96.0938% (minimum 97%, Missing); heart muscle: 87.2340% (minimum 99%, Missing); hippocampal formation: 64.3979% (minimum 99%, Missing); hypothalamus: 75.4601% (minimum 99%, Missing); kidney: 82.0000% (minimum 99%, Missing); liver: 89.1304% (minimum 99%, Missing); lymph node: 96.8504% (minimum 97%, Missing); midbrain: 83.6735% (minimum 99%, Missing); pancreas: 90.4412% (minimum 99%, Missing); parathyroid gland: 85.4167% (minimum 97%, Missing); pituitary gland: 68.7151% (minimum 99%, Missing); retina: 66.8478% (minimum 99%, Missing); salivary gland: 93.1818% (minimum 97%, Missing); skeletal muscle: 82.0000% (minimum 99%, Missing); small intestine: 93.8931% (minimum 99%, Missing); smooth muscle: 68.7151% (minimum 99%, Missing); spinal cord: 89.1304% (minimum 99%, Missing); stomach: 96.8504% (minimum 97%, Missing); thyroid gland: 93.1818% (minimum 95%, Missing); urinary bladder: 95.3488% (minimum 97%, Missing)",0,80,unavailable,19.4,2.3,0.9,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); parathyroid gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000107518,ATRNL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0181818,-0.127534,-0.601987
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,5.6,2.5,3.6,"retina: 5.6 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000107614,TRDMT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.5806% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.2712% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.8182% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.9474% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.2712% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.2712% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.5862% (minimum 99%, Baseline (adaptation disabled)); colon: 80.3571% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.9057% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.3571% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.5862% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.3571% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.3571% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.2308% (minimum 99%, Baseline (adaptation disabled)); liver: 86.5385% (minimum 99%, Baseline (adaptation disabled)); lung: 76.2712% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.1818% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.8182% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.2712% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.2857% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.5862% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 44.5545% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.2712% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.9474% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.5862% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.3571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.5862% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.5862% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.4416% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.5556% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.7447% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 81.8182% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,5.6,2.5,3.6,"retina: 5.6 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000107614,TRDMT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.394444,-0.327143,-0.544455
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.5806% (minimum 90%, Approved); adrenal gland: 76.2712% (minimum 99%, Missing); amygdala: 81.8182% (minimum 99%, Missing); basal ganglia: 78.9474% (minimum 99%, Missing); bone marrow: 76.2712% (minimum 99%, Missing); cerebellum: 76.2712% (minimum 99%, Missing); cerebral cortex: 83.3333% (minimum 99%, Missing); choroid plexus: 77.5862% (minimum 99%, Missing); colon: 80.3571% (minimum 97%, Missing); duodenum: 84.9057% (minimum 99%, Missing); esophagus: 80.3571% (minimum 97%, Missing); heart muscle: 77.5862% (minimum 99%, Missing); hippocampal formation: 80.3571% (minimum 99%, Missing); hypothalamus: 80.3571% (minimum 99%, Missing); kidney: 69.2308% (minimum 99%, Missing); liver: 86.5385% (minimum 99%, Missing); lung: 76.2712% (minimum 99%, Missing); lymph node: 68.1818% (minimum 97%, Missing); midbrain: 81.8182% (minimum 99%, Missing); pancreas: 76.2712% (minimum 99%, Missing); parathyroid gland: 64.2857% (minimum 97%, Missing); pituitary gland: 77.5862% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 44.5545% (minimum 99%, Missing); salivary gland: 76.2712% (minimum 97%, Missing); skeletal muscle: 78.9474% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 77.5862% (minimum 99%, Missing); smooth muscle: 80.3571% (minimum 99%, Missing); spinal cord: 77.5862% (minimum 99%, Missing); spleen: 77.5862% (minimum 95%, Missing); stomach: 75.0000% (minimum 97%, Missing); thymus: 58.4416% (minimum 95%, Missing); thyroid gland: 55.5556% (minimum 95%, Missing); tongue: 95.7447% (minimum 97%, Missing); urinary bladder: 81.8182% (minimum 97%, Missing)",0,1,partial,5.6,2.5,3.6,"retina: 5.6 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000107614,TRDMT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.394444,-0.327143,-0.544455
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,114.3,36,46.5,"bone marrow: 114.3 nTPM (vital, limit 2); thymus: 46.5 nTPM (manageable, limit 5); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 2); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 4); lymph node: 34.8 nTPM (protected, limit 2); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 2); spleen: 25.1 nTPM (manageable, limit 10); heart muscle: 24 nTPM (vital, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 2); stomach: 17.1 nTPM (protected, limit 4); adrenal gland: 17 nTPM (vital, limit 2); small intestine: 15.7 nTPM (vital, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 10); lung: 15.7 nTPM (vital, limit 2); urinary bladder: 15.7 nTPM (protected, limit 2); skeletal muscle: 14.9 nTPM (vital, limit 2); smooth muscle: 14.5 nTPM (vital, limit 2); kidney: 12.7 nTPM (vital, limit 2); salivary gland: 11.7 nTPM (protected, limit 4); skin: 11.6 nTPM (manageable, limit 10); liver: 11.2 nTPM (vital, limit 2); duodenum: 11 nTPM (vital, limit 2); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 4); pancreas: 7.5 nTPM (vital, limit 2); parathyroid gland: 6.5 nTPM (protected, limit 4); tongue: 5.4 nTPM (protected, limit 2)",colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000108106,UBE2S,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.7429% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.0527% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.8298% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.4146% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 57.3826% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.5951% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.8723% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8055% (minimum 99%, Baseline (adaptation disabled)); colon: 89.5809% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3293% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.0427% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.5093% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.7027% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.3770% (minimum 99%, Baseline (adaptation disabled)); liver: 93.2162% (minimum 99%, Baseline (adaptation disabled)); lung: 90.7429% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.5580% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.9807% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.3532% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.9476% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.5604% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.4751% (minimum 97%, Baseline (adaptation disabled)); retina: 94.4172% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.9348% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.1730% (minimum 99%, Baseline (adaptation disabled)); skin: 92.9909% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.7429% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.3895% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.7313% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.9777% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 76.7964% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.8987% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.6102% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.7429% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,114.3,36,46.5,"bone marrow: 114.3 nTPM (vital, limit 1); thymus: 46.5 nTPM (manageable, limit 5); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 1); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 2); lymph node: 34.8 nTPM (protected, limit 2); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 1); spleen: 25.1 nTPM (manageable, limit 5); heart muscle: 24 nTPM (vital, limit 1); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 2); stomach: 17.1 nTPM (protected, limit 2); adrenal gland: 17 nTPM (vital, limit 1); small intestine: 15.7 nTPM (vital, limit 1); adipose tissue: 15.7 nTPM (manageable, limit 5); lung: 15.7 nTPM (vital, limit 1); urinary bladder: 15.7 nTPM (protected, limit 2); skeletal muscle: 14.9 nTPM (vital, limit 1); smooth muscle: 14.5 nTPM (vital, limit 1); kidney: 12.7 nTPM (vital, limit 1); salivary gland: 11.7 nTPM (protected, limit 2); skin: 11.6 nTPM (manageable, limit 5); liver: 11.2 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 2); pancreas: 7.5 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 2); tongue: 5.4 nTPM (protected, limit 2)",colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000108106,UBE2S,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.182036,-0.159573,-0.416174
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.0527% (minimum 98%, Approved); amygdala: 80.8298% (minimum 99%, Missing); basal ganglia: 83.4146% (minimum 99%, Missing); bone marrow: 57.3826% (minimum 98%, Approved); cerebellum: 85.5951% (minimum 98%, Approved); cerebral cortex: 80.8723% (minimum 98%, Approved); choroid plexus: 88.8055% (minimum 99%, Missing); colon: 89.5809% (minimum 97%, Missing); duodenum: 93.3293% (minimum 98%, Approved); esophagus: 81.0427% (minimum 95%, Approved); heart muscle: 86.5093% (minimum 98%, Approved); hippocampal formation: 80.7027% (minimum 99%, Missing); hypothalamus: 81.0000% (minimum 99%, Missing); kidney: 92.3770% (minimum 98%, Approved); liver: 93.2162% (minimum 98%, Approved); lung: 90.7429% (minimum 98%, Approved); lymph node: 81.5580% (minimum 97%, Missing); midbrain: 84.9807% (minimum 99%, Missing); pancreas: 95.3532% (minimum 98%, Approved); pituitary gland: 84.5604% (minimum 99%, Missing); rectum: 94.4751% (minimum 95%, Approved); retina: 94.4172% (minimum 99%, Missing); salivary gland: 92.9348% (minimum 95%, Approved); skeletal muscle: 91.1730% (minimum 98%, Approved); small intestine: 90.7429% (minimum 98%, Approved); smooth muscle: 91.3895% (minimum 98%, Approved); spinal cord: 81.7313% (minimum 99%, Missing); spleen: 85.9777% (minimum 90%, Approved); stomach: 90.0000% (minimum 95%, Approved); thymus: 76.7964% (minimum 95%, Missing); tongue: 96.6102% (minimum 97%, Missing); urinary bladder: 90.7429% (minimum 97%, Missing)",0,0,routine_complete,114.3,36,46.5,"bone marrow: 114.3 nTPM (vital, limit 2); thymus: 46.5 nTPM (manageable, limit 5); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 2); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 4); lymph node: 34.8 nTPM (protected, limit 2); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 2); spleen: 25.1 nTPM (manageable, limit 10); heart muscle: 24 nTPM (vital, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 2); stomach: 17.1 nTPM (protected, limit 4); adrenal gland: 17 nTPM (vital, limit 2); small intestine: 15.7 nTPM (vital, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 10); lung: 15.7 nTPM (vital, limit 2); urinary bladder: 15.7 nTPM (protected, limit 2); skeletal muscle: 14.9 nTPM (vital, limit 2); smooth muscle: 14.5 nTPM (vital, limit 2); kidney: 12.7 nTPM (vital, limit 2); salivary gland: 11.7 nTPM (protected, limit 4); skin: 11.6 nTPM (manageable, limit 10); liver: 11.2 nTPM (vital, limit 2); duodenum: 11 nTPM (vital, limit 2); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 4); pancreas: 7.5 nTPM (vital, limit 2); parathyroid gland: 6.5 nTPM (protected, limit 4); tongue: 5.4 nTPM (protected, limit 2)",colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000108106,UBE2S,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.182036,-0.15442,-0.406174
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,25.4,26.9,15.6,"parathyroid gland: 26.9 nTPM (protected, limit 2); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); choroid plexus: 18.7 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 2); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 2); thyroid gland: 13.6 nTPM (manageable, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 2); lymph node: 12.6 nTPM (protected, limit 2); hypothalamus: 12.6 nTPM (vital, limit 1); rectum: 12.2 nTPM (protected, limit 2); salivary gland: 11.9 nTPM (protected, limit 2); colon: 11.3 nTPM (protected, limit 2); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); spleen: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 2); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); bone marrow: 7.5 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000108666,C17orf75,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 76.5766% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.3472% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.4432% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.0306% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.2727% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.0438% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.5000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 57.6923% (minimum 99%, Baseline (adaptation disabled)); colon: 69.2935% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.4062% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.6923% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.8310% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.9291% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.4348% (minimum 99%, Baseline (adaptation disabled)); liver: 64.5570% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.9291% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.4823% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.7539% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 48.6641% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.0622% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.6393% (minimum 97%, Baseline (adaptation disabled)); retina: 50.0982% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.1818% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.1415% (minimum 99%, Baseline (adaptation disabled)); skin: 78.4615% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.8333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.8310% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.2291% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.2759% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.9291% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.0438% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.2174% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.0510% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.2759% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,25.4,26.9,15.6,"parathyroid gland: 26.9 nTPM (protected, limit 2); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 1); choroid plexus: 18.7 nTPM (vital, limit 1); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 2); thyroid gland: 13.6 nTPM (manageable, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); hypothalamus: 12.6 nTPM (vital, limit 1); lymph node: 12.6 nTPM (protected, limit 2); stomach: 12.6 nTPM (protected, limit 2); rectum: 12.2 nTPM (protected, limit 2); salivary gland: 11.9 nTPM (protected, limit 2); colon: 11.3 nTPM (protected, limit 2); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); spleen: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 2); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); bone marrow: 7.5 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000108666,C17orf75,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.329562,-0.483359,-0.489018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 76.5766% (minimum 90%, Approved); adrenal gland: 62.3472% (minimum 99%, Missing); amygdala: 72.4432% (minimum 99%, Missing); basal ganglia: 71.0306% (minimum 99%, Missing); bone marrow: 77.2727% (minimum 99%, Missing); cerebellum: 62.0438% (minimum 99%, Missing); cerebral cortex: 62.5000% (minimum 99%, Missing); choroid plexus: 57.6923% (minimum 99%, Missing); colon: 69.2935% (minimum 97%, Missing); duodenum: 66.4062% (minimum 99%, Missing); esophagus: 75.0000% (minimum 97%, Missing); heart muscle: 57.6923% (minimum 98%, Approved); hippocampal formation: 71.8310% (minimum 99%, Missing); hypothalamus: 66.9291% (minimum 99%, Missing); kidney: 55.4348% (minimum 99%, Missing); liver: 64.5570% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 66.9291% (minimum 97%, Missing); midbrain: 69.4823% (minimum 99%, Missing); pancreas: 66.7539% (minimum 99%, Missing); parathyroid gland: 48.6641% (minimum 97%, Missing); pituitary gland: 66.0622% (minimum 99%, Missing); rectum: 67.6393% (minimum 97%, Missing); retina: 50.0982% (minimum 99%, Missing); salivary gland: 68.1818% (minimum 97%, Missing); skeletal muscle: 60.1415% (minimum 99%, Missing); skin: 78.4615% (minimum 95%, Missing); small intestine: 70.8333% (minimum 99%, Missing); smooth muscle: 71.8310% (minimum 99%, Missing); spinal cord: 71.2291% (minimum 99%, Missing); spleen: 73.2759% (minimum 95%, Missing); stomach: 66.9291% (minimum 97%, Missing); thymus: 62.0438% (minimum 95%, Missing); thyroid gland: 65.2174% (minimum 95%, Missing); tongue: 65.0510% (minimum 97%, Missing); urinary bladder: 73.2759% (minimum 97%, Missing)",0,7,partial,25.4,26.9,15.6,"parathyroid gland: 26.9 nTPM (protected, limit 2); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); choroid plexus: 18.7 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 2); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 2); thyroid gland: 13.6 nTPM (manageable, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 2); lymph node: 12.6 nTPM (protected, limit 2); hypothalamus: 12.6 nTPM (vital, limit 1); rectum: 12.2 nTPM (protected, limit 2); salivary gland: 11.9 nTPM (protected, limit 2); colon: 11.3 nTPM (protected, limit 2); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); spleen: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 2); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); bone marrow: 7.5 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000108666,C17orf75,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.329562,-0.483359,-0.489018
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,4.3,5.9,6.1,"hippocampal formation: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000108786,HSD17B1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.8810% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.7914% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.3724% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.2560% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.7933% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.6061% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.3724% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.5520% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.1075% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.5520% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.9085% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.0767% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.0767% (minimum 99%, Baseline (adaptation disabled)); liver: 97.5520% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1527% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.9085% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.4891% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1951% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.6783% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.8810% (minimum 99%, Baseline (adaptation disabled)); skin: 92.8904% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.4328% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.3724% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,4.3,5.9,6.1,"skin: 6.1 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 2); skeletal muscle: 4.3 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000108786,HSD17B1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.0210956,-0.0389252,-0.0411905
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.3724% (minimum 99%, Missing); basal ganglia: 96.2560% (minimum 99%, Missing); choroid plexus: 96.3724% (minimum 99%, Missing); hippocampal formation: 95.9085% (minimum 99%, Missing); hypothalamus: 97.0767% (minimum 99%, Missing); midbrain: 95.9085% (minimum 99%, Missing); pituitary gland: 97.1951% (minimum 99%, Missing); skeletal muscle: 94.8810% (minimum 95%, Enhanced); spinal cord: 96.3724% (minimum 99%, Missing)",0,1,partial,4.3,5.9,6.1,"hippocampal formation: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000108786,HSD17B1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0450062,0.03,-0.0309146
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,69.6,94.8,31.7,"tongue: 94.8 nTPM (protected, limit 2); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 2); smooth muscle: 34.2 nTPM (vital, limit 1); skin: 31.7 nTPM (manageable, limit 5); parathyroid gland: 29.6 nTPM (protected, limit 4); colon: 26.4 nTPM (protected, limit 2); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 2); adipose tissue: 24.2 nTPM (manageable, limit 10); thymus: 24 nTPM (manageable, limit 5); rectum: 24 nTPM (protected, limit 2); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); salivary gland: 19.4 nTPM (protected, limit 4); kidney: 18.5 nTPM (vital, limit 2); stomach: 18.1 nTPM (protected, limit 4); small intestine: 16.9 nTPM (vital, limit 2); lymph node: 16.6 nTPM (protected, limit 4); spleen: 16 nTPM (manageable, limit 10); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); pancreas: 14.6 nTPM (vital, limit 2); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 2); cerebral cortex: 6.1 nTPM (vital, limit 2); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000109171,SLAIN2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.3053% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.1905% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.3362% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.3362% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 71.4286% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.5801% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.7679% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.9727% (minimum 99%, Baseline (adaptation disabled)); colon: 60.2410% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.3296% (minimum 99%, Baseline (adaptation disabled)); esophagus: 51.3479% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 50.5051% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.1057% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.1057% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.3761% (minimum 99%, Baseline (adaptation disabled)); liver: 60.5144% (minimum 99%, Baseline (adaptation disabled)); lung: 65.7895% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.6714% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.7679% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.2601% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.4713% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.0336% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 71.5564% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 67.3401% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 36.4964% (minimum 99%, Baseline (adaptation disabled)); skin: 55.7880% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.2988% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.9084% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.1057% (minimum 99%, Baseline (adaptation disabled)); spleen: 71.4286% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.8468% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.5000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.2252% (minimum 95%, Baseline (adaptation disabled)); tongue: 29.6736% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.0687% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,69.6,94.8,31.7,"tongue: 94.8 nTPM (protected, limit 2); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 2); smooth muscle: 34.2 nTPM (vital, limit 1); skin: 31.7 nTPM (manageable, limit 5); parathyroid gland: 29.6 nTPM (protected, limit 2); colon: 26.4 nTPM (protected, limit 2); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 2); adipose tissue: 24.2 nTPM (manageable, limit 5); thymus: 24 nTPM (manageable, limit 5); rectum: 24 nTPM (protected, limit 2); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); salivary gland: 19.4 nTPM (protected, limit 2); kidney: 18.5 nTPM (vital, limit 1); stomach: 18.1 nTPM (protected, limit 2); small intestine: 16.9 nTPM (vital, limit 1); lymph node: 16.6 nTPM (protected, limit 2); spleen: 16 nTPM (manageable, limit 5); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); pancreas: 14.6 nTPM (vital, limit 1); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000109171,SLAIN2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.39212,-0.673264,-0.625036
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.3053% (minimum 90%, Approved); adrenal gland: 76.1905% (minimum 98%, Approved); amygdala: 87.3362% (minimum 99%, Missing); basal ganglia: 87.3362% (minimum 99%, Missing); bone marrow: 71.4286% (minimum 99%, Missing); cerebellum: 86.5801% (minimum 98%, Approved); cerebral cortex: 86.7679% (minimum 98%, Approved); choroid plexus: 77.9727% (minimum 99%, Missing); colon: 60.2410% (minimum 97%, Missing); duodenum: 75.3296% (minimum 99%, Missing); esophagus: 51.3479% (minimum 97%, Missing); heart muscle: 50.5051% (minimum 99%, Missing); hippocampal formation: 88.1057% (minimum 99%, Missing); hypothalamus: 88.1057% (minimum 99%, Missing); kidney: 68.3761% (minimum 98%, Approved); liver: 60.5144% (minimum 99%, Missing); lung: 65.7895% (minimum 99%, Missing); lymph node: 70.6714% (minimum 95%, Approved); midbrain: 86.7679% (minimum 99%, Missing); pancreas: 73.2601% (minimum 98%, Approved); parathyroid gland: 57.4713% (minimum 95%, Approved); pituitary gland: 84.0336% (minimum 99%, Missing); rectum: 62.5000% (minimum 97%, Missing); retina: 71.5564% (minimum 99%, Missing); salivary gland: 67.3401% (minimum 95%, Approved); skeletal muscle: 36.4964% (minimum 99%, Missing); skin: 55.7880% (minimum 95%, Missing); small intestine: 70.2988% (minimum 98%, Approved); smooth muscle: 53.9084% (minimum 99%, Missing); spinal cord: 88.1057% (minimum 99%, Missing); spleen: 71.4286% (minimum 90%, Approved); stomach: 68.8468% (minimum 95%, Approved); thymus: 62.5000% (minimum 95%, Missing); thyroid gland: 66.2252% (minimum 95%, Missing); tongue: 29.6736% (minimum 97%, Missing); urinary bladder: 61.0687% (minimum 97%, Missing)",0,1,partial,69.6,94.8,31.7,"tongue: 94.8 nTPM (protected, limit 2); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 2); smooth muscle: 34.2 nTPM (vital, limit 1); skin: 31.7 nTPM (manageable, limit 5); parathyroid gland: 29.6 nTPM (protected, limit 4); colon: 26.4 nTPM (protected, limit 2); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 2); adipose tissue: 24.2 nTPM (manageable, limit 10); thymus: 24 nTPM (manageable, limit 5); rectum: 24 nTPM (protected, limit 2); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); salivary gland: 19.4 nTPM (protected, limit 4); kidney: 18.5 nTPM (vital, limit 2); stomach: 18.1 nTPM (protected, limit 4); small intestine: 16.9 nTPM (vital, limit 2); lymph node: 16.6 nTPM (protected, limit 4); spleen: 16 nTPM (manageable, limit 10); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); pancreas: 14.6 nTPM (vital, limit 2); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 2); cerebral cortex: 6.1 nTPM (vital, limit 2); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000109171,SLAIN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.39212,-0.673264,-0.625036
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,28,16.4,13.5,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 2); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 2); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 2); cerebellum: 12.9 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); thyroid gland: 12.8 nTPM (manageable, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 2); esophagus: 10 nTPM (protected, limit 2); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); spleen: 9.2 nTPM (manageable, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 2); skin: 7.5 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000109184,DCUN1D4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 48.9614% (minimum 99%, Baseline (adaptation disabled)); amygdala: 56.7010% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.5556% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.4922% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.1224% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 52.8846% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.3243% (minimum 99%, Baseline (adaptation disabled)); colon: 53.2258% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.3243% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.2642% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.5106% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.5556% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 47.0085% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.5714% (minimum 99%, Baseline (adaptation disabled)); liver: 37.0787% (minimum 99%, Baseline (adaptation disabled)); lung: 65.2174% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.3277% (minimum 97%, Baseline (adaptation disabled)); midbrain: 52.3810% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.2174% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.2023% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 51.8868% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.8016% (minimum 97%, Baseline (adaptation disabled)); retina: 52.0505% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.7432% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 59.1398% (minimum 99%, Baseline (adaptation disabled)); skin: 68.7500% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.7066% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 49.8489% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.7459% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.2023% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.1224% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.3684% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.3140% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.2190% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.1520% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,28,16.4,13.5,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 2); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 2); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 2); cerebellum: 12.9 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); thyroid gland: 12.8 nTPM (manageable, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 2); esophagus: 10 nTPM (protected, limit 2); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); spleen: 9.2 nTPM (manageable, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 2); skin: 7.5 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000109184,DCUN1D4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.4,-0.46848,-0.619213
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0000% (minimum 95%, Missing); adrenal gland: 48.9614% (minimum 99%, Missing); amygdala: 56.7010% (minimum 99%, Missing); basal ganglia: 55.5556% (minimum 99%, Missing); bone marrow: 85.4922% (minimum 99%, Missing); cerebellum: 56.1224% (minimum 99%, Missing); cerebral cortex: 52.8846% (minimum 99%, Missing); choroid plexus: 74.3243% (minimum 99%, Missing); colon: 53.2258% (minimum 97%, Missing); duodenum: 74.3243% (minimum 99%, Missing); esophagus: 62.2642% (minimum 97%, Missing); heart muscle: 58.5106% (minimum 99%, Uncertain); hippocampal formation: 55.5556% (minimum 99%, Missing); hypothalamus: 47.0085% (minimum 99%, Missing); kidney: 53.5714% (minimum 99%, Missing); liver: 37.0787% (minimum 99%, Missing); lung: 65.2174% (minimum 99%, Missing); lymph node: 69.3277% (minimum 97%, Missing); midbrain: 52.3810% (minimum 99%, Missing); pancreas: 65.2174% (minimum 99%, Missing); parathyroid gland: 64.2023% (minimum 97%, Missing); pituitary gland: 51.8868% (minimum 99%, Missing); rectum: 66.8016% (minimum 97%, Missing); retina: 52.0505% (minimum 99%, Missing); salivary gland: 55.7432% (minimum 97%, Missing); skeletal muscle: 59.1398% (minimum 99%, Uncertain); skin: 68.7500% (minimum 95%, Missing); small intestine: 63.7066% (minimum 99%, Missing); smooth muscle: 49.8489% (minimum 99%, Missing); spinal cord: 53.7459% (minimum 99%, Missing); spleen: 64.2023% (minimum 95%, Missing); stomach: 56.1224% (minimum 97%, Missing); thymus: 72.3684% (minimum 95%, Missing); thyroid gland: 56.3140% (minimum 95%, Missing); tongue: 60.2190% (minimum 97%, Missing); urinary bladder: 50.1520% (minimum 97%, Missing)",0,3,partial,28,16.4,13.5,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 2); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 2); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 2); cerebellum: 12.9 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); thyroid gland: 12.8 nTPM (manageable, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 2); esophagus: 10 nTPM (protected, limit 2); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); spleen: 9.2 nTPM (manageable, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 2); skin: 7.5 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000109184,DCUN1D4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.4,-0.46848,-0.619213
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,18.8,8.8,2.3,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 2); rectum: 7.5 nTPM (protected, limit 2); parathyroid gland: 5.8 nTPM (protected, limit 2); cerebral cortex: 5.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000109265,CRACD,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 93.1148% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.5081% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.4211% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 87.9257% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.9094% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.2845% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9547% (minimum 99%, Baseline (adaptation disabled)); colon: 76.3441% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.7651% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.2603% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.8105% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.3846% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5945% (minimum 99%, Baseline (adaptation disabled)); liver: 97.9310% (minimum 99%, Baseline (adaptation disabled)); lung: 97.2603% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.1148% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.0282% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.6229% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.0409% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.9283% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.1086% (minimum 97%, Baseline (adaptation disabled)); retina: 87.3846% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.5986% (minimum 97%, Baseline (adaptation disabled)); small intestine: 60.1695% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.3846% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.2078% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.5081% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.6129% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.9459% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,18.8,8.8,2.3,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 2); rectum: 7.5 nTPM (protected, limit 2); parathyroid gland: 5.8 nTPM (protected, limit 2); cerebral cortex: 5.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000109265,CRACD,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0249186,-0.206559,-0.388305
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 93.1148% (minimum 99%, Missing); amygdala: 92.5081% (minimum 99%, Missing); basal ganglia: 93.4211% (minimum 99%, Missing); bone marrow: 87.9257% (minimum 99%, Missing); cerebellum: 91.9094% (minimum 99%, Missing); cerebral cortex: 83.2845% (minimum 99%, Missing); choroid plexus: 98.9547% (minimum 99%, Missing); colon: 76.3441% (minimum 97%, Missing); duodenum: 68.7651% (minimum 99%, Missing); heart muscle: 97.2603% (minimum 99%, Missing); hippocampal formation: 92.8105% (minimum 99%, Missing); hypothalamus: 87.3846% (minimum 99%, Missing); kidney: 97.5945% (minimum 99%, Missing); liver: 97.9310% (minimum 99%, Uncertain); lung: 97.2603% (minimum 99%, Uncertain); lymph node: 93.1148% (minimum 97%, Uncertain); midbrain: 89.0282% (minimum 99%, Missing); pancreas: 95.6229% (minimum 99%, Missing); parathyroid gland: 83.0409% (minimum 97%, Missing); pituitary gland: 96.9283% (minimum 99%, Missing); rectum: 79.1086% (minimum 97%, Missing); retina: 87.3846% (minimum 99%, Missing); salivary gland: 96.5986% (minimum 97%, Missing); small intestine: 60.1695% (minimum 99%, Missing); smooth muscle: 87.3846% (minimum 99%, Missing); spinal cord: 92.2078% (minimum 99%, Missing); spleen: 92.5081% (minimum 95%, Uncertain); stomach: 91.6129% (minimum 97%, Missing); urinary bladder: 95.9459% (minimum 97%, Missing)",0,1,partial,18.8,8.8,2.3,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 2); rectum: 7.5 nTPM (protected, limit 2); parathyroid gland: 5.8 nTPM (protected, limit 2); cerebral cortex: 5.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000109265,CRACD,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0249186,-0.206559,-0.388305
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,25.3,5.1,5.5,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); colon: 5.1 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); salivary gland: 3.7 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109618,SEPSECS,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.0870% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.0247% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.1159% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.1176% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.6792% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 58.0247% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.4375% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.8065% (minimum 99%, Baseline (adaptation disabled)); colon: 47.9592% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.2564% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.5135% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.2778% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.1159% (minimum 99%, Baseline (adaptation disabled)); kidney: 37.3016% (minimum 99%, Baseline (adaptation disabled)); liver: 15.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 55.2941% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.1493% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 39.4958% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.4937% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.0390% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.5135% (minimum 97%, Baseline (adaptation disabled)); retina: 75.8065% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.9524% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.7500% (minimum 99%, Baseline (adaptation disabled)); skin: 48.4536% (minimum 95%, Baseline (adaptation disabled)); small intestine: 38.8430% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 54.0230% (minimum 99%, Baseline (adaptation disabled)); spleen: 46.0784% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.9583% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.4536% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.2778% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.9524% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,25.3,5.1,5.5,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); colon: 5.1 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); salivary gland: 3.7 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109618,SEPSECS,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.489216,-0.490408,-0.833333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.0870% (minimum 95%, Missing); adrenal gland: 58.0247% (minimum 99%, Missing); amygdala: 68.1159% (minimum 99%, Missing); basal ganglia: 69.1176% (minimum 99%, Missing); bone marrow: 88.6792% (minimum 99%, Missing); cerebellum: 58.0247% (minimum 99%, Missing); cerebral cortex: 73.4375% (minimum 99%, Missing); choroid plexus: 75.8065% (minimum 99%, Missing); colon: 47.9592% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 60.2564% (minimum 97%, Missing); heart muscle: 63.5135% (minimum 99%, Missing); hippocampal formation: 65.2778% (minimum 99%, Missing); hypothalamus: 68.1159% (minimum 99%, Missing); kidney: 37.3016% (minimum 99%, Missing); liver: 15.6667% (minimum 99%, Missing); lung: 55.2941% (minimum 99%, Missing); lymph node: 70.1493% (minimum 97%, Missing); midbrain: 62.6667% (minimum 99%, Missing); pancreas: 39.4958% (minimum 99%, Missing); parathyroid gland: 59.4937% (minimum 97%, Missing); pituitary gland: 61.0390% (minimum 99%, Missing); rectum: 63.5135% (minimum 97%, Missing); retina: 75.8065% (minimum 99%, Missing); salivary gland: 55.9524% (minimum 97%, Missing); skeletal muscle: 58.7500% (minimum 99%, Missing); skin: 48.4536% (minimum 95%, Missing); small intestine: 38.8430% (minimum 99%, Missing); smooth muscle: 78.3333% (minimum 99%, Missing); spinal cord: 54.0230% (minimum 99%, Missing); spleen: 46.0784% (minimum 95%, Missing); stomach: 48.9583% (minimum 97%, Missing); thymus: 48.4536% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 65.2778% (minimum 97%, Missing); urinary bladder: 55.9524% (minimum 97%, Missing)",0,80,unavailable,25.3,5.1,5.5,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); colon: 5.1 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); salivary gland: 3.7 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109618,SEPSECS,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.489216,-0.490408,-0.833333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.5,3.5,23,"thymus: 23 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109674,NEIL3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 18.7500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.2353% (minimum 99%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.6923% (minimum 99%, Baseline (adaptation disabled)); esophagus: 50.0000% (minimum 97%, Baseline (adaptation disabled)); liver: 88.2353% (minimum 99%, Baseline (adaptation disabled)); lung: 93.7500% (minimum 99%, Baseline (adaptation disabled)); lymph node: 30.0000% (minimum 97%, Baseline (adaptation disabled)); rectum: 51.7241% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 88.2353% (minimum 97%, Baseline (adaptation disabled)); skin: 39.4737% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.5556% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.9474% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.4286% (minimum 97%, Baseline (adaptation disabled)); thymus: 6.1224% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 78.9474% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.5,3.5,23,"thymus: 23 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109674,NEIL3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.888776,-0.67,-0.8025
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Missing); bone marrow: 18.7500% (minimum 99%, Missing); cerebral cortex: 88.2353% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 57.6923% (minimum 99%, Missing); esophagus: 50.0000% (minimum 97%, Missing); liver: 88.2353% (minimum 99%, Missing); lung: 93.7500% (minimum 99%, Missing); lymph node: 30.0000% (minimum 97%, Missing); rectum: 51.7241% (minimum 97%, Missing); salivary gland: 88.2353% (minimum 97%, Missing); skin: 39.4737% (minimum 95%, Missing); small intestine: 55.5556% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spleen: 78.9474% (minimum 95%, Missing); stomach: 71.4286% (minimum 97%, Missing); thymus: 6.1224% (minimum 95%, Missing); urinary bladder: 78.9474% (minimum 97%, Missing)",0,80,unavailable,6.5,3.5,23,"thymus: 23 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109674,NEIL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.888776,-0.67,-0.8025
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,6.1,2.6,1.4,"kidney: 6.1 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000109684,CLNK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.5714% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.6154% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 78.5714% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.7500% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.5714% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.6154% (minimum 99%, Baseline (adaptation disabled)); kidney: 15.2778% (minimum 99%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 99%, Baseline (adaptation disabled)); lung: 68.7500% (minimum 99%, Baseline (adaptation disabled)); lymph node: 29.7297% (minimum 97%, Baseline (adaptation disabled)); pancreas: 91.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 47.8261% (minimum 99%, Baseline (adaptation disabled)); rectum: 73.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 78.5714% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 57.8947% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.8947% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 44.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.8261% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.6154% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 84.6154% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,6.1,2.6,1.4,"kidney: 6.1 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000109684,CLNK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.51,-0.672703,-0.837222
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.5714% (minimum 95%, Uncertain); adrenal gland: 84.6154% (minimum 99%, Uncertain); bone marrow: 73.3333% (minimum 99%, Uncertain); cerebral cortex: 91.6667% (minimum 99%, Uncertain); choroid plexus: 91.6667% (minimum 99%, Missing); colon: 78.5714% (minimum 97%, Uncertain); duodenum: 68.7500% (minimum 99%, Uncertain); esophagus: 78.5714% (minimum 97%, Uncertain); heart muscle: 84.6154% (minimum 99%, Uncertain); kidney: 15.2778% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Uncertain); lung: 68.7500% (minimum 99%, Uncertain); lymph node: 29.7297% (minimum 97%, Missing); pancreas: 91.6667% (minimum 99%, Missing); parathyroid gland: 91.6667% (minimum 97%, Uncertain); pituitary gland: 47.8261% (minimum 99%, Missing); rectum: 73.3333% (minimum 97%, Uncertain); retina: 78.5714% (minimum 99%, Missing); salivary gland: 73.3333% (minimum 97%, Uncertain); skeletal muscle: 91.6667% (minimum 99%, Uncertain); skin: 57.8947% (minimum 95%, Uncertain); small intestine: 57.8947% (minimum 99%, Uncertain); smooth muscle: 91.6667% (minimum 99%, Uncertain); spleen: 44.0000% (minimum 95%, Uncertain); stomach: 50.0000% (minimum 97%, Uncertain); thymus: 47.8261% (minimum 95%, Missing); thyroid gland: 84.6154% (minimum 95%, Uncertain); urinary bladder: 84.6154% (minimum 97%, Uncertain)",0,3,partial,6.1,2.6,1.4,"kidney: 6.1 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000109684,CLNK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.51,-0.672703,-0.837222
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,28,3.5,3.4,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 2); lung: 4.3 nTPM (vital, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000109771,LRP2BP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.8710% (minimum 99%, Baseline (adaptation disabled)); amygdala: 58.1006% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.5217% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.2963% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 45.2174% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.7571% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.2857% (minimum 99%, Baseline (adaptation disabled)); colon: 74.8201% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.1963% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.2281% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.8201% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.9140% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.8860% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.8742% (minimum 99%, Baseline (adaptation disabled)); liver: 87.3950% (minimum 99%, Baseline (adaptation disabled)); lung: 70.7483% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.5455% (minimum 97%, Baseline (adaptation disabled)); midbrain: 67.0968% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.0370% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 38.0952% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.2963% (minimum 97%, Baseline (adaptation disabled)); retina: 27.0833% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.1356% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.1955% (minimum 99%, Baseline (adaptation disabled)); skin: 87.3950% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.2459% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.1963% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.5963% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.6667% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 75.3623% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.6937% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.8710% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,28,3.5,3.4,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000109771,LRP2BP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.196377,-0.221799,-0.719167
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.6667% (minimum 90%, Approved); adrenal gland: 83.8710% (minimum 98%, Approved); amygdala: 58.1006% (minimum 99%, Missing); basal ganglia: 56.5217% (minimum 99%, Missing); bone marrow: 96.2963% (minimum 98%, Approved); cerebellum: 45.2174% (minimum 99%, Missing); cerebral cortex: 58.7571% (minimum 99%, Missing); choroid plexus: 74.2857% (minimum 99%, Missing); colon: 74.8201% (minimum 97%, Missing); duodenum: 97.1963% (minimum 98%, Approved); esophagus: 91.2281% (minimum 95%, Approved); heart muscle: 74.8201% (minimum 99%, Missing); hippocampal formation: 55.9140% (minimum 99%, Missing); hypothalamus: 53.8860% (minimum 99%, Missing); kidney: 68.8742% (minimum 98%, Approved); liver: 87.3950% (minimum 98%, Approved); lung: 70.7483% (minimum 98%, Approved); lymph node: 94.5455% (minimum 95%, Approved); midbrain: 67.0968% (minimum 99%, Missing); pancreas: 77.0370% (minimum 98%, Approved); pituitary gland: 38.0952% (minimum 99%, Missing); retina: 27.0833% (minimum 99%, Missing); salivary gland: 88.1356% (minimum 95%, Approved); skeletal muscle: 78.1955% (minimum 99%, Missing); skin: 87.3950% (minimum 95%, Missing); small intestine: 85.2459% (minimum 98%, Approved); smooth muscle: 97.1963% (minimum 99%, Missing); spinal cord: 64.5963% (minimum 99%, Missing); spleen: 80.0000% (minimum 90%, Approved); stomach: 86.6667% (minimum 95%, Approved); thyroid gland: 75.3623% (minimum 90%, Approved); tongue: 93.6937% (minimum 97%, Missing); urinary bladder: 83.8710% (minimum 95%, Approved)",0,2,partial,28,3.5,3.4,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 2); lung: 4.3 nTPM (vital, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000109771,LRP2BP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.146377,-0.221799,-0.719167
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,22,1.6,4.6,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 6); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109832,DDX25,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.1554% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.0588% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.4348% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.9761% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.1444% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.5572% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.7470% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.5279% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.2618% (minimum 99%, Baseline (adaptation disabled)); midbrain: 88.4462% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.4479% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 85.9632% (minimum 99%, Baseline (adaptation disabled)); retina: 80.7273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.9733% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,22,1.6,4.6,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109832,DDX25,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.000749465,0.0123009,-0.188556
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 87.0588% (minimum 99%, Missing); basal ganglia: 80.4348% (minimum 99%, Missing); cerebellum: 84.9761% (minimum 95%, Enhanced); cerebral cortex: 80.1444% (minimum 99%, Missing); choroid plexus: 98.5572% (minimum 99%, Missing); hippocampal formation: 87.7470% (minimum 99%, Missing); hypothalamus: 82.5279% (minimum 99%, Missing); midbrain: 88.4462% (minimum 99%, Missing); pituitary gland: 85.9632% (minimum 99%, Missing); retina: 80.7273% (minimum 99%, Missing); spinal cord: 94.9733% (minimum 99%, Missing)",0,4,partial,22,1.6,4.6,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 6); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109832,DDX25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0432886,0.0288751,-0.188556
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000109851,DBX1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000109851,DBX1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000109851,DBX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,21.7,9.8,15.4,"choroid plexus: 21.7 nTPM (vital, limit 1); thymus: 15.4 nTPM (manageable, limit 5); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 2); stomach: 9 nTPM (protected, limit 2); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 2); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); retina: 6 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 2); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); urinary bladder: 3.2 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109881,CCDC34,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.7593% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.2857% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.2518% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.4348% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.7049% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.2346% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.1918% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.5962% (minimum 99%, Baseline (adaptation disabled)); colon: 84.7943% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.0069% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.9431% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.4911% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.2518% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.6155% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.8046% (minimum 99%, Baseline (adaptation disabled)); liver: 91.3295% (minimum 99%, Baseline (adaptation disabled)); lung: 95.3722% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.1041% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.6310% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.8605% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.8696% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 89.7727% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.8671% (minimum 97%, Baseline (adaptation disabled)); retina: 88.7640% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.2179% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.0476% (minimum 99%, Baseline (adaptation disabled)); skin: 88.2682% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.4920% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.4911% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.8605% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.8605% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.0426% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.4777% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.7727% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.6759% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 93.6759% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,21.7,9.8,15.4,"choroid plexus: 21.7 nTPM (vital, limit 1); thymus: 15.4 nTPM (manageable, limit 5); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 2); stomach: 9 nTPM (protected, limit 2); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 2); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); retina: 6 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 2); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); urinary bladder: 3.2 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109881,CCDC34,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.195223,-0.141329,-0.304038
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.7593% (minimum 95%, Missing); adrenal gland: 90.2857% (minimum 99%, Missing); amygdala: 85.2518% (minimum 99%, Missing); basal ganglia: 82.4348% (minimum 99%, Missing); bone marrow: 77.7049% (minimum 99%, Missing); cerebellum: 94.2346% (minimum 99%, Missing); cerebral cortex: 84.1918% (minimum 99%, Missing); choroid plexus: 68.5962% (minimum 99%, Missing); colon: 84.7943% (minimum 97%, Missing); duodenum: 82.0069% (minimum 99%, Missing); esophagus: 89.9431% (minimum 97%, Missing); heart muscle: 93.4911% (minimum 99%, Missing); hippocampal formation: 85.2518% (minimum 99%, Missing); hypothalamus: 87.6155% (minimum 99%, Missing); kidney: 90.8046% (minimum 99%, Missing); liver: 91.3295% (minimum 99%, Missing); lung: 95.3722% (minimum 99%, Missing); lymph node: 88.1041% (minimum 97%, Missing); midbrain: 90.6310% (minimum 99%, Missing); pancreas: 91.8605% (minimum 99%, Missing); parathyroid gland: 85.8696% (minimum 97%, Missing); pituitary gland: 89.7727% (minimum 99%, Missing); rectum: 82.8671% (minimum 97%, Missing); retina: 88.7640% (minimum 99%, Missing); salivary gland: 92.2179% (minimum 97%, Missing); skeletal muscle: 94.0476% (minimum 99%, Missing); skin: 88.2682% (minimum 95%, Missing); small intestine: 84.4920% (minimum 99%, Missing); smooth muscle: 93.4911% (minimum 99%, Missing); spinal cord: 91.8605% (minimum 99%, Missing); spleen: 91.8605% (minimum 95%, Missing); stomach: 84.0426% (minimum 97%, Missing); thymus: 75.4777% (minimum 95%, Missing); thyroid gland: 89.7727% (minimum 95%, Missing); tongue: 93.6759% (minimum 97%, Missing); urinary bladder: 93.6759% (minimum 97%, Missing)",0,80,unavailable,21.7,9.8,15.4,"choroid plexus: 21.7 nTPM (vital, limit 1); thymus: 15.4 nTPM (manageable, limit 5); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 2); stomach: 9 nTPM (protected, limit 2); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 2); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); retina: 6 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 2); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); urinary bladder: 3.2 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000109881,CCDC34,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.195223,-0.141329,-0.304038
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,1.7,0.8,0.7,"basal ganglia: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000109927,TECTA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.7273% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.5385% (minimum 99%, Baseline (adaptation disabled)); amygdala: 57.1429% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 34.7826% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 36.3636% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 32.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 38.0952% (minimum 99%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.8889% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 42.1053% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 40.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.5385% (minimum 99%, Baseline (adaptation disabled)); liver: 66.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 66.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8889% (minimum 97%, Baseline (adaptation disabled)); midbrain: 53.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.7273% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 38.0952% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 42.1053% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.7273% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 53.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 88.8889% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.1429% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.7273% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.7273% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 72.7273% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.7273% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,1.7,0.8,0.7,"cerebral cortex: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000109927,TECTA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.416667,-0.47,-0.67
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.7273% (minimum 95%, Missing); adrenal gland: 61.5385% (minimum 98%, Approved); amygdala: 57.1429% (minimum 99%, Missing); basal ganglia: 34.7826% (minimum 99%, Missing); bone marrow: 80.0000% (minimum 98%, Approved); cerebellum: 36.3636% (minimum 98%, Approved); cerebral cortex: 32.0000% (minimum 98%, Approved); choroid plexus: 38.0952% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 88.8889% (minimum 99%, Missing); esophagus: 88.8889% (minimum 97%, Missing); heart muscle: 42.1053% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 40.0000% (minimum 99%, Missing); kidney: 61.5385% (minimum 99%, Missing); liver: 66.6667% (minimum 98%, Approved); lung: 66.6667% (minimum 99%, Missing); lymph node: 88.8889% (minimum 95%, Approved); midbrain: 53.3333% (minimum 99%, Missing); pancreas: 72.7273% (minimum 99%, Missing); parathyroid gland: 50.0000% (minimum 95%, Approved); pituitary gland: 38.0952% (minimum 99%, Missing); rectum: 88.8889% (minimum 95%, Approved); retina: 42.1053% (minimum 99%, Missing); salivary gland: 72.7273% (minimum 95%, Approved); skeletal muscle: 53.3333% (minimum 98%, Approved); skin: 88.8889% (minimum 95%, Missing); small intestine: 80.0000% (minimum 98%, Approved); smooth muscle: 80.0000% (minimum 98%, Approved); spinal cord: 57.1429% (minimum 99%, Missing); spleen: 72.7273% (minimum 90%, Approved); stomach: 72.7273% (minimum 95%, Approved); thymus: 80.0000% (minimum 95%, Missing); thyroid gland: 53.3333% (minimum 90%, Approved); tongue: 72.7273% (minimum 97%, Missing); urinary bladder: 72.7273% (minimum 95%, Approved)",0,3,partial,1.7,0.8,0.7,"basal ganglia: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000109927,TECTA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.366667,-0.45,-0.66
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,69.3,65.2,26.7,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 2); rectum: 43.2 nTPM (protected, limit 2); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 2); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); parathyroid gland: 26.7 nTPM (protected, limit 2); salivary gland: 25.2 nTPM (protected, limit 2); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (manageable, limit 15); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); esophagus: 21.3 nTPM (protected, limit 2); choroid plexus: 18.9 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 2); basal ganglia: 18.1 nTPM (vital, limit 1); skin: 16.4 nTPM (manageable, limit 5); lymph node: 15.5 nTPM (protected, limit 2); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 2); midbrain: 13.7 nTPM (vital, limit 1); thymus: 13.6 nTPM (manageable, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000110090,CPT1A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1435% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 47.8599% (minimum 99%, Baseline (adaptation disabled)); amygdala: 66.3073% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 57.6112% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 39.0476% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.6735% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.9077% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 56.5517% (minimum 99%, Baseline (adaptation disabled)); colon: 27.3942% (minimum 97%, Baseline (adaptation disabled)); duodenum: 26.3666% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.5948% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.9298% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.5664% (minimum 99%, Baseline (adaptation disabled)); kidney: 39.8703% (minimum 99%, Baseline (adaptation disabled)); liver: 27.1823% (minimum 99%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.3466% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.2298% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.7895% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 47.9532% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.7306% (minimum 99%, Baseline (adaptation disabled)); rectum: 36.2832% (minimum 97%, Baseline (adaptation disabled)); retina: 52.9032% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 49.3976% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.9298% (minimum 99%, Baseline (adaptation disabled)); skin: 60.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 26.1981% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 42.2680% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.3922% (minimum 99%, Baseline (adaptation disabled)); spleen: 47.9532% (minimum 95%, Baseline (adaptation disabled)); stomach: 41.4840% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.3979% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.1212% (minimum 95%, Baseline (adaptation disabled)); tongue: 64.2298% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.6112% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,69.3,65.2,26.7,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 2); rectum: 43.2 nTPM (protected, limit 2); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 2); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); parathyroid gland: 26.7 nTPM (protected, limit 2); salivary gland: 25.2 nTPM (protected, limit 2); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (manageable, limit 5); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); esophagus: 21.3 nTPM (protected, limit 2); choroid plexus: 18.9 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 2); basal ganglia: 18.1 nTPM (vital, limit 1); skin: 16.4 nTPM (manageable, limit 5); lymph node: 15.5 nTPM (protected, limit 2); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 2); midbrain: 13.7 nTPM (vital, limit 1); thymus: 13.6 nTPM (manageable, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000110090,CPT1A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.470468,-0.696058,-0.728019
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1435% (minimum 80%, Supported); adrenal gland: 47.8599% (minimum 99%, Missing); amygdala: 66.3073% (minimum 99%, Missing); basal ganglia: 57.6112% (minimum 99%, Missing); bone marrow: 39.0476% (minimum 99%, Missing); cerebellum: 83.6735% (minimum 99%, Missing); cerebral cortex: 64.9077% (minimum 99%, Missing); choroid plexus: 56.5517% (minimum 99%, Missing); colon: 27.3942% (minimum 97%, Missing); duodenum: 26.3666% (minimum 99%, Missing); esophagus: 53.5948% (minimum 97%, Missing); heart muscle: 50.0000% (minimum 99%, Missing); hippocampal formation: 71.9298% (minimum 99%, Missing); hypothalamus: 72.5664% (minimum 99%, Missing); kidney: 39.8703% (minimum 99%, Missing); liver: 27.1823% (minimum 99%, Missing); lung: 50.0000% (minimum 99%, Missing); lymph node: 61.3466% (minimum 97%, Missing); midbrain: 64.2298% (minimum 99%, Missing); pancreas: 51.7895% (minimum 99%, Missing); parathyroid gland: 47.9532% (minimum 97%, Missing); pituitary gland: 63.7306% (minimum 99%, Missing); rectum: 36.2832% (minimum 97%, Missing); retina: 52.9032% (minimum 99%, Missing); salivary gland: 49.3976% (minimum 97%, Missing); skeletal muscle: 71.9298% (minimum 99%, Missing); skin: 60.0000% (minimum 95%, Missing); small intestine: 26.1981% (minimum 99%, Missing); smooth muscle: 42.2680% (minimum 99%, Missing); spinal cord: 80.3922% (minimum 99%, Missing); spleen: 47.9532% (minimum 95%, Missing); stomach: 41.4840% (minimum 97%, Missing); thymus: 64.3979% (minimum 95%, Missing); thyroid gland: 62.1212% (minimum 95%, Missing); tongue: 64.2298% (minimum 97%, Missing); urinary bladder: 57.6112% (minimum 97%, Missing)",0,6,partial,69.3,65.2,26.7,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 2); rectum: 43.2 nTPM (protected, limit 2); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 2); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); parathyroid gland: 26.7 nTPM (protected, limit 2); salivary gland: 25.2 nTPM (protected, limit 2); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (manageable, limit 15); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); esophagus: 21.3 nTPM (protected, limit 2); choroid plexus: 18.9 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 2); basal ganglia: 18.1 nTPM (vital, limit 1); skin: 16.4 nTPM (manageable, limit 5); lymph node: 15.5 nTPM (protected, limit 2); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 2); midbrain: 13.7 nTPM (vital, limit 1); thymus: 13.6 nTPM (manageable, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000110090,CPT1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.470468,-0.696058,-0.728019
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,66.5,82,55.8,"tongue: 82 nTPM (protected, limit 2); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (manageable, limit 10); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 2); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (manageable, limit 5); urinary bladder: 31.2 nTPM (protected, limit 2); esophagus: 29.8 nTPM (protected, limit 2); spleen: 29.8 nTPM (manageable, limit 5); colon: 29.7 nTPM (protected, limit 2); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); thymus: 24.8 nTPM (manageable, limit 5); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 2); salivary gland: 22.3 nTPM (protected, limit 2); skin: 21.7 nTPM (manageable, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 2); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 2); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000110422,HIPK3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 37.7926% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.9744% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.1798% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.5744% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.4737% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.8344% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 71.9745% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.0832% (minimum 99%, Baseline (adaptation disabled)); colon: 53.3019% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.6647% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.2182% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 39.5566% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.1798% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.0175% (minimum 99%, Baseline (adaptation disabled)); kidney: 47.9491% (minimum 99%, Baseline (adaptation disabled)); liver: 53.9809% (minimum 99%, Baseline (adaptation disabled)); lung: 56.5000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.3203% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.1794% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.5552% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 42.8571% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.0603% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.0112% (minimum 97%, Baseline (adaptation disabled)); retina: 60.9712% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.3203% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 33.7649% (minimum 99%, Baseline (adaptation disabled)); skin: 60.9712% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.2463% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 47.2145% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.5299% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.2182% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.3020% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.7513% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.9009% (minimum 95%, Baseline (adaptation disabled)); tongue: 29.2494% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.0737% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,66.5,82,55.8,"tongue: 82 nTPM (protected, limit 2); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (manageable, limit 5); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 2); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (manageable, limit 5); urinary bladder: 31.2 nTPM (protected, limit 2); esophagus: 29.8 nTPM (protected, limit 2); spleen: 29.8 nTPM (manageable, limit 5); colon: 29.7 nTPM (protected, limit 2); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); thymus: 24.8 nTPM (manageable, limit 5); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 2); salivary gland: 22.3 nTPM (protected, limit 2); skin: 21.7 nTPM (manageable, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 2); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 2); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000110422,HIPK3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.572074,-0.677506,-0.652351
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 37.7926% (minimum 90%, Approved); adrenal gland: 61.9744% (minimum 99%, Missing); amygdala: 76.1798% (minimum 99%, Missing); basal ganglia: 77.5744% (minimum 99%, Missing); bone marrow: 59.4737% (minimum 99%, Missing); cerebellum: 74.8344% (minimum 99%, Missing); cerebral cortex: 71.9745% (minimum 99%, Missing); choroid plexus: 64.0832% (minimum 99%, Missing); colon: 53.3019% (minimum 97%, Missing); duodenum: 67.6647% (minimum 99%, Missing); esophagus: 53.2182% (minimum 97%, Missing); heart muscle: 39.5566% (minimum 99%, Missing); hippocampal formation: 76.1798% (minimum 99%, Missing); hypothalamus: 74.0175% (minimum 99%, Missing); kidney: 47.9491% (minimum 99%, Missing); liver: 53.9809% (minimum 99%, Missing); lung: 56.5000% (minimum 99%, Missing); lymph node: 60.3203% (minimum 97%, Missing); midbrain: 74.1794% (minimum 99%, Missing); pancreas: 57.5552% (minimum 99%, Missing); parathyroid gland: 42.8571% (minimum 97%, Missing); pituitary gland: 73.0603% (minimum 99%, Missing); rectum: 63.0112% (minimum 97%, Missing); retina: 60.9712% (minimum 99%, Missing); salivary gland: 60.3203% (minimum 97%, Missing); skeletal muscle: 33.7649% (minimum 99%, Missing); skin: 60.9712% (minimum 95%, Missing); small intestine: 63.2463% (minimum 99%, Missing); smooth muscle: 47.2145% (minimum 99%, Missing); spinal cord: 67.5299% (minimum 99%, Missing); spleen: 53.2182% (minimum 95%, Missing); stomach: 61.3020% (minimum 97%, Missing); thymus: 57.7513% (minimum 95%, Missing); thyroid gland: 50.9009% (minimum 95%, Missing); tongue: 29.2494% (minimum 97%, Missing); urinary bladder: 52.0737% (minimum 97%, Missing)",0,3,partial,66.5,82,55.8,"tongue: 82 nTPM (protected, limit 2); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (manageable, limit 10); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 2); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (manageable, limit 5); urinary bladder: 31.2 nTPM (protected, limit 2); esophagus: 29.8 nTPM (protected, limit 2); spleen: 29.8 nTPM (manageable, limit 5); colon: 29.7 nTPM (protected, limit 2); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); thymus: 24.8 nTPM (manageable, limit 5); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 2); salivary gland: 22.3 nTPM (protected, limit 2); skin: 21.7 nTPM (manageable, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 2); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 2); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000110422,HIPK3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.522074,-0.677506,-0.652351
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,15,partial,26.5,5.7,5.5,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 6); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); skin: 5.5 nTPM (manageable, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),87,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / fibrohistiocytic cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000110693,SOX6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.1026% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.4474% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.8851% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.2865% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 34.4059% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.2055% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.5000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.1026% (minimum 99%, Baseline (adaptation disabled)); colon: 92.0530% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.1542% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.4214% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.2335% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.2424% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.7561% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.7347% (minimum 99%, Baseline (adaptation disabled)); liver: 75.1351% (minimum 99%, Baseline (adaptation disabled)); lung: 94.5578% (minimum 99%, Baseline (adaptation disabled)); midbrain: 82.7381% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.8049% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 83.2335% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.0530% (minimum 97%, Baseline (adaptation disabled)); retina: 82.2485% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.5278% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.6987% (minimum 99%, Baseline (adaptation disabled)); skin: 71.6495% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.5041% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.8873% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.2597% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.2886% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.2597% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.2865% (minimum 95%, Baseline (adaptation disabled)); tongue: 70.9184% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.2055% (minimum 97%, Baseline (adaptation disabled))",0,15,partial,26.5,5.7,5.5,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); skin: 5.5 nTPM (manageable, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),87,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / fibrohistiocytic cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000110693,SOX6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.233505,-0.260816,-0.645941
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.1026% (minimum 95%, Missing); adrenal gland: 91.4474% (minimum 95%, Enhanced); amygdala: 79.8851% (minimum 99%, Missing); basal ganglia: 81.2865% (minimum 99%, Missing); bone marrow: 34.4059% (minimum 99%, Missing); cerebellum: 95.2055% (minimum 99%, Missing); cerebral cortex: 69.5000% (minimum 99%, Missing); choroid plexus: 89.1026% (minimum 99%, Missing); colon: 92.0530% (minimum 97%, Missing); duodenum: 69.1542% (minimum 99%, Missing); heart muscle: 83.2335% (minimum 95%, Enhanced); hippocampal formation: 84.2424% (minimum 99%, Missing); hypothalamus: 84.7561% (minimum 99%, Missing); kidney: 56.7347% (minimum 95%, Enhanced); liver: 75.1351% (minimum 99%, Missing); lung: 94.5578% (minimum 99%, Missing); midbrain: 82.7381% (minimum 99%, Missing); pancreas: 67.8049% (minimum 99%, Missing); pituitary gland: 83.2335% (minimum 99%, Missing); rectum: 92.0530% (minimum 97%, Missing); retina: 82.2485% (minimum 99%, Missing); skeletal muscle: 60.6987% (minimum 99%, Missing); skin: 71.6495% (minimum 95%, Missing); small intestine: 56.5041% (minimum 99%, Missing); spinal cord: 90.2597% (minimum 99%, Missing); stomach: 93.2886% (minimum 97%, Missing); thymus: 90.2597% (minimum 95%, Missing); tongue: 70.9184% (minimum 97%, Missing)",0,15,partial,26.5,5.7,5.5,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 6); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); skin: 5.5 nTPM (manageable, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),87,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / fibrohistiocytic cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000110693,SOX6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.233505,-0.260816,-0.645941
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.7,0,,,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000110975,SYT10,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.7778% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.4545% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.3043% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.4138% (minimum 99%, Baseline (adaptation disabled)); liver: 87.5000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 84.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 95.4545% (minimum 99%, Baseline (adaptation disabled)); small intestine: 87.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.4545% (minimum 99%, Baseline (adaptation disabled)); stomach: 84.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.7,0,,,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000110975,SYT10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,-0.22,-0.265862
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 87.5000% (minimum 99%, Missing); basal ganglia: 84.0000% (minimum 99%, Missing); cerebral cortex: 77.7778% (minimum 99%, Missing); choroid plexus: 95.4545% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 91.3043% (minimum 99%, Missing); hypothalamus: 84.0000% (minimum 99%, Missing); kidney: 72.4138% (minimum 99%, Missing); liver: 87.5000% (minimum 99%, Missing); pituitary gland: 84.0000% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 95.4545% (minimum 99%, Missing); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 95.4545% (minimum 99%, Missing); stomach: 84.0000% (minimum 97%, Missing)",0,80,unavailable,0.8,0.7,0,,,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000110975,SYT10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,-0.22,-0.265862
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,27.6,3.8,4.9,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 2); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 2); heart muscle: 6.1 nTPM (vital, limit 2); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000111052,LIN7A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5954% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.2143% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.1212% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.6000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 22.9050% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 29.9270% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.6173% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.6355% (minimum 99%, Baseline (adaptation disabled)); colon: 81.1881% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.2529% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.1099% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.3427% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.0769% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 59.4203% (minimum 99%, Baseline (adaptation disabled)); kidney: 49.3976% (minimum 99%, Baseline (adaptation disabled)); liver: 32.4111% (minimum 99%, Baseline (adaptation disabled)); lung: 62.5954% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.9259% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.5659% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.2529% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.1099% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.5714% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.2529% (minimum 97%, Baseline (adaptation disabled)); retina: 24.1176% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.1111% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.1304% (minimum 99%, Baseline (adaptation disabled)); skin: 92.1348% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.3922% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.0794% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.1881% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.5669% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.1720% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.1818% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.3585% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.3333% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,27.6,3.8,4.9,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000111052,LIN7A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.324046,-0.286667,-0.76095
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5954% (minimum 90%, Approved); adrenal gland: 73.2143% (minimum 99%, Missing); amygdala: 62.1212% (minimum 99%, Missing); basal ganglia: 65.6000% (minimum 99%, Missing); bone marrow: 22.9050% (minimum 99%, Missing); cerebellum: 29.9270% (minimum 98%, Approved); cerebral cortex: 50.6173% (minimum 98%, Approved); choroid plexus: 76.6355% (minimum 99%, Missing); colon: 81.1881% (minimum 97%, Missing); duodenum: 94.2529% (minimum 99%, Missing); esophagus: 90.1099% (minimum 95%, Approved); heart muscle: 57.3427% (minimum 98%, Approved); hippocampal formation: 63.0769% (minimum 99%, Missing); hypothalamus: 59.4203% (minimum 99%, Missing); kidney: 49.3976% (minimum 99%, Missing); liver: 32.4111% (minimum 99%, Missing); lung: 62.5954% (minimum 98%, Approved); lymph node: 75.9259% (minimum 95%, Approved); midbrain: 63.5659% (minimum 99%, Missing); pancreas: 94.2529% (minimum 98%, Approved); parathyroid gland: 90.1099% (minimum 95%, Approved); pituitary gland: 58.5714% (minimum 99%, Missing); rectum: 94.2529% (minimum 97%, Missing); retina: 24.1176% (minimum 99%, Missing); salivary gland: 91.1111% (minimum 97%, Missing); skeletal muscle: 89.1304% (minimum 98%, Approved); small intestine: 80.3922% (minimum 99%, Missing); smooth muscle: 65.0794% (minimum 99%, Missing); spinal cord: 81.1881% (minimum 99%, Missing); spleen: 64.5669% (minimum 95%, Missing); stomach: 88.1720% (minimum 95%, Approved); thymus: 93.1818% (minimum 95%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); tongue: 77.3585% (minimum 97%, Missing); urinary bladder: 68.3333% (minimum 95%, Approved)",0,4,partial,27.6,3.8,4.9,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 2); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 2); heart muscle: 6.1 nTPM (vital, limit 2); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000111052,LIN7A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.304331,-0.266667,-0.76095
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,16.7,8.7,14,"bone marrow: 16.7 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 8.7 nTPM (protected, limit 2); rectum: 6.3 nTPM (protected, limit 2); colon: 5 nTPM (protected, limit 2); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111247,RAD51AP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.1429% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.4058% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.0448% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.0448% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 26.7544% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.7059% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.1429% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.8254% (minimum 99%, Baseline (adaptation disabled)); colon: 54.9550% (minimum 97%, Baseline (adaptation disabled)); duodenum: 54.9550% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.3043% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.4242% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.0448% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.4242% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.4058% (minimum 99%, Baseline (adaptation disabled)); liver: 77.2152% (minimum 99%, Baseline (adaptation disabled)); lung: 82.4324% (minimum 99%, Baseline (adaptation disabled)); lymph node: 41.2162% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.1429% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.8462% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.0448% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.3125% (minimum 99%, Baseline (adaptation disabled)); rectum: 49.1935% (minimum 97%, Baseline (adaptation disabled)); retina: 80.2632% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.9155% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.8462% (minimum 99%, Baseline (adaptation disabled)); skin: 66.3043% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.4815% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 77.2152% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.7222% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.8936% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.1149% (minimum 97%, Baseline (adaptation disabled)); thymus: 30.3483% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.9155% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.0448% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 79.2208% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,16.7,8.7,14,"bone marrow: 16.7 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 8.7 nTPM (protected, limit 2); rectum: 6.3 nTPM (protected, limit 2); colon: 5 nTPM (protected, limit 2); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111247,RAD51AP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.646517,-0.557838,-0.722456
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.1429% (minimum 95%, Missing); adrenal gland: 88.4058% (minimum 99%, Missing); amygdala: 91.0448% (minimum 99%, Missing); basal ganglia: 91.0448% (minimum 99%, Missing); bone marrow: 26.7544% (minimum 99%, Missing); cerebellum: 89.7059% (minimum 99%, Missing); cerebral cortex: 87.1429% (minimum 99%, Missing); choroid plexus: 96.8254% (minimum 99%, Missing); colon: 54.9550% (minimum 97%, Missing); duodenum: 54.9550% (minimum 99%, Missing); esophagus: 66.3043% (minimum 97%, Missing); heart muscle: 92.4242% (minimum 99%, Missing); hippocampal formation: 91.0448% (minimum 99%, Missing); hypothalamus: 92.4242% (minimum 99%, Missing); kidney: 88.4058% (minimum 99%, Missing); liver: 77.2152% (minimum 99%, Missing); lung: 82.4324% (minimum 99%, Missing); lymph node: 41.2162% (minimum 97%, Missing); midbrain: 87.1429% (minimum 99%, Missing); pancreas: 93.8462% (minimum 99%, Missing); parathyroid gland: 91.0448% (minimum 97%, Missing); pituitary gland: 95.3125% (minimum 99%, Missing); rectum: 49.1935% (minimum 97%, Missing); retina: 80.2632% (minimum 99%, Missing); salivary gland: 85.9155% (minimum 97%, Missing); skeletal muscle: 93.8462% (minimum 99%, Missing); skin: 66.3043% (minimum 95%, Missing); small intestine: 56.4815% (minimum 99%, Missing); smooth muscle: 77.2152% (minimum 99%, Missing); spinal cord: 84.7222% (minimum 99%, Missing); spleen: 64.8936% (minimum 95%, Missing); stomach: 70.1149% (minimum 97%, Missing); thymus: 30.3483% (minimum 95%, Missing); thyroid gland: 85.9155% (minimum 95%, Missing); tongue: 91.0448% (minimum 97%, Missing); urinary bladder: 79.2208% (minimum 97%, Missing)",0,80,unavailable,16.7,8.7,14,"bone marrow: 16.7 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 8.7 nTPM (protected, limit 2); rectum: 6.3 nTPM (protected, limit 2); colon: 5 nTPM (protected, limit 2); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111247,RAD51AP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.646517,-0.557838,-0.722456
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,4.1,1.5,1.6,"spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111254,AKAP3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.9817% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.9817% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.9526% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.7805% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.8852% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9817% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.3806% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0827% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.9817% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.7867% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,4.1,1.5,1.6,"heart muscle: 4.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111254,AKAP3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,0.0338057,0.0148024,-0.0304738
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.9817% (minimum 99%, Missing); basal ganglia: 98.9817% (minimum 99%, Missing); hippocampal formation: 98.7805% (minimum 99%, Missing); midbrain: 98.3806% (minimum 99%, Missing); pituitary gland: 98.9817% (minimum 99%, Missing); spinal cord: 97.7867% (minimum 99%, Missing)",0,3,partial,4.1,1.5,1.6,"spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111254,AKAP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,0.0418367,0.0248823,-0.0121328
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,29.5,0.3,0.2,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111305,GSG1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 97.3225% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.8647% (minimum 99%, Baseline (adaptation disabled)); retina: 93.4078% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,29.5,0.3,0.2,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111305,GSG1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0495218,0.0292828,-0.0559218
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 97.3225% (minimum 99%, Missing); pancreas: 98.8647% (minimum 99%, Missing); retina: 93.4078% (minimum 99%, Missing)",0,80,unavailable,29.5,0.3,0.2,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111305,GSG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0495218,0.0292828,-0.0559218
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,10.5,5.4,13.4,"bone marrow: 10.5 nTPM (vital, limit 6); duodenum: 8.2 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6); retina: 1.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111644,ACRBP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.3300% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7460% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.1106% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.9943% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.2134% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,10.5,5.4,13.4,"thyroid gland: 13.4 nTPM (manageable, limit 5); bone marrow: 10.5 nTPM (vital, limit 1); spleen: 8.9 nTPM (manageable, limit 5); duodenum: 8.2 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111644,ACRBP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.00363322,0.0107829,-0.0267005
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,10.5,5.4,13.4,"bone marrow: 10.5 nTPM (vital, limit 6); duodenum: 8.2 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6); retina: 1.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000111644,ACRBP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0392319,0.0285507,0.00386946
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,115.3,4.5,0.7,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000111837,MAK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.5455% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.1132% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.2963% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.2281% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.6552% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1132% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.1132% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 42.9752% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.1132% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.1132% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.8571% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.2281% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.2963% (minimum 99%, Baseline (adaptation disabled)); lung: 88.1356% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.1132% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.2963% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 53.6082% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 4.3154% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.2963% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.1132% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.1132% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.1132% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.1356% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.5455% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,115.3,4.5,0.7,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000111837,MAK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0686441,-0.433918,-0.946846
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.5455% (minimum 95%, Missing); adrenal gland: 98.1132% (minimum 99%, Missing); amygdala: 96.2963% (minimum 99%, Missing); basal ganglia: 91.2281% (minimum 99%, Missing); bone marrow: 89.6552% (minimum 99%, Missing); cerebellum: 98.1132% (minimum 99%, Missing); cerebral cortex: 98.1132% (minimum 99%, Missing); choroid plexus: 42.9752% (minimum 99%, Missing); duodenum: 98.1132% (minimum 99%, Missing); heart muscle: 98.1132% (minimum 99%, Missing); hippocampal formation: 92.8571% (minimum 99%, Missing); hypothalamus: 91.2281% (minimum 99%, Missing); kidney: 96.2963% (minimum 99%, Missing); lung: 88.1356% (minimum 99%, Missing); midbrain: 98.1132% (minimum 99%, Missing); pancreas: 96.2963% (minimum 99%, Missing); parathyroid gland: 53.6082% (minimum 97%, Missing); pituitary gland: 86.6667% (minimum 99%, Missing); retina: 4.3154% (minimum 99%, Missing); salivary gland: 96.2963% (minimum 97%, Missing); skeletal muscle: 98.1132% (minimum 99%, Missing); small intestine: 98.1132% (minimum 99%, Missing); spinal cord: 98.1132% (minimum 99%, Missing); spleen: 88.1356% (minimum 95%, Missing); stomach: 94.5455% (minimum 97%, Missing)",0,80,unavailable,115.3,4.5,0.7,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000111837,MAK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0686441,-0.433918,-0.946846
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,108.6,81.2,22.7,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 2); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 2); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); salivary gland: 24.8 nTPM (protected, limit 2); stomach: 24.2 nTPM (protected, limit 2); cerebellum: 23.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 22.7 nTPM (vital, limit 1); esophagus: 21.5 nTPM (protected, limit 2); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 2); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 2); adipose tissue: 17.4 nTPM (manageable, limit 5); rectum: 17 nTPM (protected, limit 2); skin: 16.9 nTPM (manageable, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); bone marrow: 12 nTPM (vital, limit 2); lymph node: 10.9 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 10); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000111911,HINT3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2560% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 55.8366% (minimum 99%, Baseline (adaptation disabled)); amygdala: 44.4961% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 48.2353% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 70.5160% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.0864% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 47.5166% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.7396% (minimum 99%, Baseline (adaptation disabled)); colon: 60.1677% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.3759% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.1713% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.2500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 44.2901% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 48.5618% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.2854% (minimum 99%, Baseline (adaptation disabled)); liver: 51.1586% (minimum 99%, Baseline (adaptation disabled)); lung: 58.5714% (minimum 99%, Baseline (adaptation disabled)); lymph node: 72.4747% (minimum 97%, Baseline (adaptation disabled)); midbrain: 41.9591% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.6765% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.2281% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.2131% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.8009% (minimum 97%, Baseline (adaptation disabled)); retina: 66.4352% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.6449% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 20.9031% (minimum 99%, Baseline (adaptation disabled)); skin: 62.9386% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.9321% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.2159% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 33.4109% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.7789% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.2533% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.8366% (minimum 95%, Baseline (adaptation disabled)); tongue: 26.1146% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.8534% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,108.6,81.2,22.7,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 2); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 2); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); salivary gland: 24.8 nTPM (protected, limit 2); stomach: 24.2 nTPM (protected, limit 2); cerebellum: 23.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 22.7 nTPM (vital, limit 1); esophagus: 21.5 nTPM (protected, limit 2); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 2); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 2); adipose tissue: 17.4 nTPM (manageable, limit 5); rectum: 17 nTPM (protected, limit 2); skin: 16.9 nTPM (manageable, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); bone marrow: 12 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000111911,HINT3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.391634,-0.708854,-0.780969
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2560% (minimum 95%, Missing); adrenal gland: 55.8366% (minimum 99%, Missing); amygdala: 44.4961% (minimum 99%, Missing); basal ganglia: 48.2353% (minimum 99%, Missing); bone marrow: 70.5160% (minimum 98%, Approved); cerebellum: 55.0864% (minimum 99%, Missing); cerebral cortex: 47.5166% (minimum 99%, Missing); choroid plexus: 74.7396% (minimum 99%, Missing); colon: 60.1677% (minimum 97%, Missing); duodenum: 65.3759% (minimum 99%, Missing); esophagus: 57.1713% (minimum 97%, Missing); heart muscle: 51.2500% (minimum 99%, Missing); hippocampal formation: 44.2901% (minimum 99%, Missing); hypothalamus: 48.5618% (minimum 99%, Missing); kidney: 57.2854% (minimum 99%, Missing); liver: 51.1586% (minimum 99%, Missing); lung: 58.5714% (minimum 99%, Missing); lymph node: 72.4747% (minimum 97%, Missing); midbrain: 41.9591% (minimum 99%, Missing); pancreas: 60.6765% (minimum 99%, Missing); parathyroid gland: 49.2281% (minimum 97%, Missing); pituitary gland: 67.2131% (minimum 99%, Missing); rectum: 62.8009% (minimum 97%, Missing); retina: 66.4352% (minimum 99%, Missing); salivary gland: 53.6449% (minimum 97%, Missing); skeletal muscle: 20.9031% (minimum 99%, Missing); skin: 62.9386% (minimum 95%, Missing); small intestine: 64.9321% (minimum 99%, Missing); smooth muscle: 63.2159% (minimum 99%, Missing); spinal cord: 33.4109% (minimum 99%, Missing); spleen: 73.7789% (minimum 90%, Approved); stomach: 54.2533% (minimum 97%, Missing); thymus: 68.3333% (minimum 95%, Missing); thyroid gland: 55.8366% (minimum 95%, Missing); tongue: 26.1146% (minimum 97%, Missing); urinary bladder: 61.8534% (minimum 97%, Missing)",0,6,partial,108.6,81.2,22.7,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 2); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 2); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); salivary gland: 24.8 nTPM (protected, limit 2); stomach: 24.2 nTPM (protected, limit 2); cerebellum: 23.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 22.7 nTPM (vital, limit 1); esophagus: 21.5 nTPM (protected, limit 2); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 2); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 2); adipose tissue: 17.4 nTPM (manageable, limit 5); rectum: 17 nTPM (protected, limit 2); skin: 16.9 nTPM (manageable, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); bone marrow: 12 nTPM (vital, limit 2); lymph node: 10.9 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 10); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000111911,HINT3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.391634,-0.708854,-0.780969
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,43.5,14.5,26.6,"bone marrow: 43.5 nTPM (vital, limit 1); thymus: 26.6 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); stomach: 4.5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000112029,FBXO5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.0330% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.0330% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.2208% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.2632% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 12.2984% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 63.5417% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.9302% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.2500% (minimum 99%, Baseline (adaptation disabled)); colon: 55.9633% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.5472% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.8866% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 78.2051% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.2632% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.0330% (minimum 99%, Baseline (adaptation disabled)); liver: 58.6538% (minimum 99%, Baseline (adaptation disabled)); lung: 64.8936% (minimum 99%, Baseline (adaptation disabled)); lymph node: 29.6117% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.2632% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.7778% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.4940% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.3086% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.9550% (minimum 97%, Baseline (adaptation disabled)); retina: 65.5914% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.1149% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.1429% (minimum 99%, Baseline (adaptation disabled)); skin: 59.2233% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.2233% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.9633% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.2208% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.0435% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.5472% (minimum 97%, Baseline (adaptation disabled)); thymus: 18.6544% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.2233% (minimum 95%, Baseline (adaptation disabled)); tongue: 70.9302% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.6162% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,43.5,14.5,26.6,"bone marrow: 43.5 nTPM (vital, limit 1); thymus: 26.6 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); stomach: 4.5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000112029,FBXO5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.763456,-0.673883,-0.867016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.0330% (minimum 95%, Missing); adrenal gland: 67.0330% (minimum 99%, Missing); amygdala: 79.2208% (minimum 99%, Missing); basal ganglia: 80.2632% (minimum 99%, Missing); bone marrow: 12.2984% (minimum 99%, Missing); cerebellum: 63.5417% (minimum 99%, Missing); cerebral cortex: 70.9302% (minimum 99%, Missing); choroid plexus: 76.2500% (minimum 99%, Missing); colon: 55.9633% (minimum 97%, Missing); duodenum: 57.5472% (minimum 99%, Missing); esophagus: 62.8866% (minimum 97%, Missing); heart muscle: 78.2051% (minimum 99%, Missing); hippocampal formation: 80.2632% (minimum 99%, Missing); hypothalamus: 81.3333% (minimum 99%, Missing); kidney: 67.0330% (minimum 99%, Missing); liver: 58.6538% (minimum 99%, Missing); lung: 64.8936% (minimum 99%, Missing); lymph node: 29.6117% (minimum 97%, Missing); midbrain: 80.2632% (minimum 99%, Missing); pancreas: 67.7778% (minimum 99%, Missing); parathyroid gland: 73.4940% (minimum 97%, Missing); pituitary gland: 75.3086% (minimum 99%, Missing); rectum: 54.9550% (minimum 97%, Missing); retina: 65.5914% (minimum 99%, Missing); salivary gland: 70.1149% (minimum 97%, Missing); skeletal muscle: 87.1429% (minimum 99%, Missing); skin: 59.2233% (minimum 95%, Missing); small intestine: 59.2233% (minimum 99%, Missing); smooth muscle: 55.9633% (minimum 99%, Missing); spinal cord: 79.2208% (minimum 99%, Missing); spleen: 53.0435% (minimum 95%, Missing); stomach: 57.5472% (minimum 97%, Missing); thymus: 18.6544% (minimum 95%, Missing); thyroid gland: 59.2233% (minimum 95%, Missing); tongue: 70.9302% (minimum 97%, Missing); urinary bladder: 61.6162% (minimum 97%, Missing)",0,2,partial,43.5,14.5,26.6,"bone marrow: 43.5 nTPM (vital, limit 1); thymus: 26.6 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); stomach: 4.5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000112029,FBXO5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.763456,-0.673883,-0.867016
True,compatible,,True,True,False,,0,3,partial,2.1,1,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112038,OPRM1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 77.7778% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.5517% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.1429% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.3529% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.3226% (minimum 99%, Baseline (adaptation disabled)); colon: 93.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.6842% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.5517% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.5000% (minimum 97%, Baseline (adaptation disabled)); pancreas: 93.3333% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.3333% (minimum 97%, Baseline (adaptation disabled)); rectum: 93.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 75.6757% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.3226% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.3226% (minimum 99%, Baseline (adaptation disabled)); skin: 82.3529% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.5000% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.5000% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.5517% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.5517% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,2.1,1,0.6,"cerebellum: 2.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112038,OPRM1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.126471,-0.233158,-0.418571
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 77.7778% (minimum 95%, Enhanced); amygdala: 96.5517% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 80.0000% (minimum 95%, Enhanced); cerebellum: 57.1429% (minimum 95%, Enhanced); cerebral cortex: 82.3529% (minimum 95%, Enhanced); choroid plexus: 90.3226% (minimum 99%, Missing); duodenum: 93.3333% (minimum 95%, Enhanced); esophagus: 73.6842% (minimum 80%, Enhanced); hypothalamus: 87.5000% (minimum 99%, Missing); kidney: 93.3333% (minimum 95%, Enhanced); liver: 93.3333% (minimum 95%, Enhanced); lung: 93.3333% (minimum 95%, Enhanced); pancreas: 93.3333% (minimum 95%, Enhanced); retina: 75.6757% (minimum 99%, Missing); skeletal muscle: 90.3226% (minimum 95%, Enhanced); small intestine: 93.3333% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 95%, Enhanced); thymus: 93.3333% (minimum 95%, Missing); tongue: 96.5517% (minimum 97%, Missing)",0,3,partial,2.1,1,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112038,OPRM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.0166667,-0.0631579,-0.378571
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,4.9,0.1,1,"basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen,ENSG00000112053,SLC26A8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8453% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.1798% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.7275% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.4530% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.4943% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1798% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.8453% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,4.9,0.1,1,"bone marrow: 4.9 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen,ENSG00000112053,SLC26A8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0271689,0.027669,-0.0927254
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8453% (minimum 99%, Missing); basal ganglia: 96.1798% (minimum 99%, Missing); bone marrow: 89.7275% (minimum 95%, Enhanced); cerebellum: 91.4530% (minimum 95%, Enhanced); hypothalamus: 96.1798% (minimum 99%, Missing); midbrain: 98.8453% (minimum 99%, Missing)",0,2,partial,4.9,0.1,1,"basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen,ENSG00000112053,SLC26A8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.027669,-0.0527254
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,ENSG00000112116,IL17F,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,ENSG00000112116,IL17F,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,ENSG00000112116,IL17F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,7.2,17.1,12.7,"lymph node: 17.1 nTPM (protected, limit 2); thymus: 12.7 nTPM (manageable, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000112182,BACH2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 67.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.4118% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.1034% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.1034% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 27.2727% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.3750% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.6957% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.1034% (minimum 99%, Baseline (adaptation disabled)); colon: 84.3750% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.8182% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.0526% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.1034% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.4286% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.0968% (minimum 99%, Baseline (adaptation disabled)); liver: 69.2308% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 13.6364% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.4286% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.0526% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.7907% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.4286% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.3750% (minimum 97%, Baseline (adaptation disabled)); retina: 67.5000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.0526% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 57.4468% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.2308% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.0526% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.1034% (minimum 99%, Baseline (adaptation disabled)); spleen: 36.4865% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.8182% (minimum 97%, Baseline (adaptation disabled)); thymus: 17.5325% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.0968% (minimum 95%, Baseline (adaptation disabled)); tongue: 54.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.5000% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,7.2,17.1,12.7,"lymph node: 17.1 nTPM (protected, limit 2); thymus: 12.7 nTPM (manageable, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000112182,BACH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.774675,-0.833636,-0.717273
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 67.5000% (minimum 95%, Missing); adrenal gland: 79.4118% (minimum 99%, Missing); amygdala: 93.1034% (minimum 99%, Missing); basal ganglia: 93.1034% (minimum 99%, Missing); bone marrow: 27.2727% (minimum 99%, Missing); cerebellum: 84.3750% (minimum 99%, Missing); cerebral cortex: 58.6957% (minimum 99%, Missing); choroid plexus: 93.1034% (minimum 99%, Missing); colon: 84.3750% (minimum 97%, Missing); duodenum: 90.0000% (minimum 99%, Missing); heart muscle: 71.0526% (minimum 99%, Missing); hippocampal formation: 93.1034% (minimum 99%, Missing); hypothalamus: 96.4286% (minimum 99%, Missing); kidney: 87.0968% (minimum 99%, Missing); liver: 69.2308% (minimum 95%, Enhanced); lung: 75.0000% (minimum 99%, Missing); lymph node: 13.6364% (minimum 97%, Missing); midbrain: 96.4286% (minimum 99%, Missing); pancreas: 71.0526% (minimum 95%, Enhanced); parathyroid gland: 62.7907% (minimum 97%, Missing); pituitary gland: 96.4286% (minimum 99%, Missing); rectum: 84.3750% (minimum 97%, Missing); retina: 67.5000% (minimum 99%, Missing); salivary gland: 71.0526% (minimum 97%, Missing); skeletal muscle: 57.4468% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 69.2308% (minimum 99%, Missing); smooth muscle: 71.0526% (minimum 99%, Missing); spinal cord: 93.1034% (minimum 99%, Missing); spleen: 36.4865% (minimum 60%, Enhanced); stomach: 81.8182% (minimum 97%, Missing); thymus: 17.5325% (minimum 95%, Missing); thyroid gland: 87.0968% (minimum 95%, Missing); tongue: 54.0000% (minimum 97%, Missing); urinary bladder: 67.5000% (minimum 97%, Missing)",0,5,partial,7.2,17.1,12.7,"lymph node: 17.1 nTPM (protected, limit 2); thymus: 12.7 nTPM (manageable, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000112182,BACH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.774675,-0.833636,-0.717273
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000112238,PRDM13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000112238,PRDM13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000112238,PRDM13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.5,0.3,1.6,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000112246,SIM1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 95%, Baseline (adaptation disabled)); hypothalamus: 77.7778% (minimum 99%, Baseline (adaptation disabled)); kidney: 22.7642% (minimum 99%, Baseline (adaptation disabled)); liver: 90.3226% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.8696% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 45.1613% (minimum 99%, Baseline (adaptation disabled)); skin: 90.3226% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.3226% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.5,0.3,1.6,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000112246,SIM1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.313636,-0.0667742,-0.762358
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 95%, Missing); hypothalamus: 77.7778% (minimum 99%, Missing); kidney: 22.7642% (minimum 99%, Missing); liver: 90.3226% (minimum 99%, Missing); pancreas: 60.8696% (minimum 99%, Missing); skeletal muscle: 45.1613% (minimum 99%, Missing); skin: 90.3226% (minimum 95%, Missing); tongue: 90.3226% (minimum 97%, Missing)",0,80,unavailable,9.5,0.3,1.6,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000112246,SIM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.313636,-0.0667742,-0.762358
True,compatible,,True,True,False,,0,2,partial,0.4,0,0,,,53,not_established,not_triggered,,,ENSG00000112273,HDGFL1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.4,0,0,,,53,not_established,not_triggered,,,ENSG00000112273,HDGFL1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.05,0.03,0.00550056
True,compatible,,True,True,True,,0,2,partial,0.4,0,0,,,53,not_established,not_triggered,,,ENSG00000112273,HDGFL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.05,0.03,0.00550056
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,21.7,17.7,17.5,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 2); thymus: 17.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); thyroid gland: 14 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); salivary gland: 12.4 nTPM (protected, limit 2); rectum: 12.1 nTPM (protected, limit 2); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 2); skin: 11.2 nTPM (manageable, limit 5); retina: 11.1 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 2); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 2); tongue: 9.7 nTPM (protected, limit 2); lung: 9.6 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 2); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112282,MED23,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 65.0943% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.1852% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.6568% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.8732% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.1176% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.0287% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.7688% (minimum 99%, Baseline (adaptation disabled)); colon: 57.5000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 55.4217% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.7273% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.6567% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.6364% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.1429% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.9832% (minimum 99%, Baseline (adaptation disabled)); liver: 64.4860% (minimum 99%, Baseline (adaptation disabled)); lung: 58.9744% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.7633% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.1852% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.2614% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 43.8095% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.0508% (minimum 99%, Baseline (adaptation disabled)); rectum: 53.2819% (minimum 97%, Baseline (adaptation disabled)); retina: 55.4217% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 52.6718% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.7143% (minimum 99%, Baseline (adaptation disabled)); skin: 55.2000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.2614% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.9832% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.1765% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.4715% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.9801% (minimum 97%, Baseline (adaptation disabled)); thymus: 44.0895% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 49.6403% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.7234% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.4746% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,21.7,17.7,17.5,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 2); thymus: 17.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); thyroid gland: 14 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); salivary gland: 12.4 nTPM (protected, limit 2); rectum: 12.1 nTPM (protected, limit 2); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 2); skin: 11.2 nTPM (manageable, limit 5); retina: 11.1 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 2); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 2); tongue: 9.7 nTPM (protected, limit 2); lung: 9.6 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 2); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112282,MED23,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.509105,-0.531905,-0.601268
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 65.0943% (minimum 95%, Missing); adrenal gland: 57.5000% (minimum 99%, Missing); amygdala: 85.1852% (minimum 99%, Missing); basal ganglia: 81.6568% (minimum 99%, Missing); bone marrow: 38.8732% (minimum 99%, Missing); cerebellum: 54.1176% (minimum 99%, Missing); cerebral cortex: 66.0287% (minimum 99%, Missing); choroid plexus: 79.7688% (minimum 99%, Missing); colon: 57.5000% (minimum 97%, Missing); duodenum: 55.4217% (minimum 99%, Missing); esophagus: 62.7273% (minimum 97%, Missing); heart muscle: 68.6567% (minimum 99%, Missing); hippocampal formation: 83.6364% (minimum 99%, Missing); hypothalamus: 82.1429% (minimum 99%, Missing); kidney: 57.9832% (minimum 99%, Missing); liver: 64.4860% (minimum 99%, Missing); lung: 58.9744% (minimum 99%, Missing); lymph node: 48.7633% (minimum 97%, Missing); midbrain: 85.1852% (minimum 99%, Missing); pancreas: 57.2614% (minimum 99%, Missing); parathyroid gland: 43.8095% (minimum 97%, Missing); pituitary gland: 70.0508% (minimum 99%, Missing); rectum: 53.2819% (minimum 97%, Missing); retina: 55.4217% (minimum 99%, Missing); salivary gland: 52.6718% (minimum 97%, Missing); skeletal muscle: 65.7143% (minimum 99%, Missing); skin: 55.2000% (minimum 95%, Missing); small intestine: 57.2614% (minimum 99%, Missing); smooth muscle: 57.9832% (minimum 99%, Missing); spinal cord: 81.1765% (minimum 99%, Missing); spleen: 52.4715% (minimum 95%, Missing); stomach: 54.9801% (minimum 97%, Missing); thymus: 44.0895% (minimum 95%, Missing); thyroid gland: 49.6403% (minimum 95%, Missing); tongue: 58.7234% (minimum 97%, Missing); urinary bladder: 58.4746% (minimum 97%, Missing)",0,80,unavailable,21.7,17.7,17.5,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 2); thymus: 17.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); thyroid gland: 14 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); salivary gland: 12.4 nTPM (protected, limit 2); rectum: 12.1 nTPM (protected, limit 2); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 2); skin: 11.2 nTPM (manageable, limit 5); retina: 11.1 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 2); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 2); tongue: 9.7 nTPM (protected, limit 2); lung: 9.6 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 2); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112282,MED23,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.509105,-0.531905,-0.601268
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,10,partial,22.2,2.2,3.4,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112541,PDE10A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8966% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.5714% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.2128% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 12.9412% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 44.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.7500% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.2857% (minimum 99%, Baseline (adaptation disabled)); colon: 78.5714% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.2857% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.1892% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 48.5294% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.4615% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.1111% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.2258% (minimum 99%, Baseline (adaptation disabled)); liver: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 76.7442% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.2857% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.2128% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.8421% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.1892% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.9322% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.2857% (minimum 97%, Baseline (adaptation disabled)); retina: 63.4615% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.1892% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 91.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.3469% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.4878% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.0000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 49.2537% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.2857% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 97%, Baseline (adaptation disabled))",0,10,partial,22.2,2.2,3.4,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112541,PDE10A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.457463,-0.37,-0.860588
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8966% (minimum 80%, Supported); adrenal gland: 78.5714% (minimum 97%, Supported); amygdala: 70.2128% (minimum 99%, Missing); basal ganglia: 12.9412% (minimum 99%, Missing); cerebellum: 44.0000% (minimum 99%, Missing); cerebral cortex: 68.7500% (minimum 97%, Supported); choroid plexus: 94.2857% (minimum 99%, Missing); colon: 78.5714% (minimum 90%, Supported); duodenum: 94.2857% (minimum 97%, Supported); esophagus: 89.1892% (minimum 90%, Supported); heart muscle: 48.5294% (minimum 97%, Supported); hippocampal formation: 63.4615% (minimum 99%, Missing); hypothalamus: 61.1111% (minimum 99%, Missing); kidney: 53.2258% (minimum 99%, Missing); liver: 91.6667% (minimum 97%, Supported); lung: 76.7442% (minimum 97%, Supported); lymph node: 94.2857% (minimum 97%, Missing); midbrain: 70.2128% (minimum 99%, Missing); pancreas: 86.8421% (minimum 97%, Supported); parathyroid gland: 89.1892% (minimum 90%, Supported); pituitary gland: 55.9322% (minimum 99%, Missing); retina: 63.4615% (minimum 99%, Missing); salivary gland: 89.1892% (minimum 90%, Supported); skeletal muscle: 91.6667% (minimum 97%, Supported); small intestine: 82.5000% (minimum 97%, Supported); smooth muscle: 67.3469% (minimum 97%, Supported); spinal cord: 80.4878% (minimum 99%, Missing); spleen: 73.3333% (minimum 80%, Supported); stomach: 75.0000% (minimum 97%, Missing); thyroid gland: 49.2537% (minimum 80%, Supported); tongue: 94.2857% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 90%, Supported)",0,10,partial,22.2,2.2,3.4,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112541,PDE10A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.307463,-0.3,-0.860588
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,621.9,4.1,4,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 6); tongue: 2.8 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112619,PRPH2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.9167% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.7778% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.3953% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.6111% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 61.4035% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.7436% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.0870% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.3448% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.9167% (minimum 99%, Baseline (adaptation disabled)); liver: 94.5946% (minimum 99%, Baseline (adaptation disabled)); lung: 71.4286% (minimum 99%, Baseline (adaptation disabled)); midbrain: 77.7778% (minimum 99%, Baseline (adaptation disabled)); pancreas: 61.4035% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 46.0526% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.3220% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.3953% (minimum 97%, Baseline (adaptation disabled)); retina: 0.5596% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 21.4724% (minimum 99%, Baseline (adaptation disabled)); skin: 92.1053% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.0377% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.3659% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.3953% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.4681% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.5946% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 46.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 55.5556% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.0870% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,621.9,4.1,4,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); pancreas: 2.2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112619,PRPH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.483333,-0.509474,-0.984404
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 83.3333% (minimum 95%, Enhanced); amygdala: 72.9167% (minimum 99%, Missing); basal ganglia: 77.7778% (minimum 99%, Missing); cerebellum: 81.3953% (minimum 95%, Enhanced); cerebral cortex: 48.6111% (minimum 95%, Enhanced); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 61.4035% (minimum 80%, Enhanced); duodenum: 89.7436% (minimum 95%, Enhanced); heart muscle: 70.0000% (minimum 95%, Enhanced); hippocampal formation: 76.0870% (minimum 99%, Missing); hypothalamus: 60.3448% (minimum 99%, Missing); kidney: 72.9167% (minimum 95%, Enhanced); liver: 94.5946% (minimum 95%, Enhanced); lung: 71.4286% (minimum 95%, Enhanced); midbrain: 77.7778% (minimum 99%, Missing); pancreas: 61.4035% (minimum 95%, Enhanced); parathyroid gland: 46.0526% (minimum 80%, Enhanced); pituitary gland: 59.3220% (minimum 99%, Missing); retina: 0.5596% (minimum 99%, Missing); skeletal muscle: 21.4724% (minimum 95%, Enhanced); small intestine: 71.4286% (minimum 95%, Enhanced); smooth muscle: 66.0377% (minimum 95%, Enhanced); spinal cord: 85.3659% (minimum 99%, Missing); stomach: 74.4681% (minimum 80%, Enhanced); thymus: 94.5946% (minimum 95%, Missing); thyroid gland: 46.6667% (minimum 60%, Enhanced); tongue: 55.5556% (minimum 97%, Missing); urinary bladder: 76.0870% (minimum 80%, Enhanced)",0,1,partial,621.9,4.1,4,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 6); tongue: 2.8 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112619,PRPH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.133333,-0.414444,-0.984404
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,25,7.9,45.4,"thymus: 45.4 nTPM (manageable, limit 5); bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); rectum: 5.7 nTPM (protected, limit 2); colon: 4.7 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000112742,TTK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.9412% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 57.1184% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.8131% (minimum 99%, Baseline (adaptation disabled)); colon: 87.6316% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.5161% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.8628% (minimum 97%, Baseline (adaptation disabled)); liver: 98.5207% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6540% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.8252% (minimum 97%, Baseline (adaptation disabled)); rectum: 85.3846% (minimum 97%, Baseline (adaptation disabled)); retina: 94.8718% (minimum 99%, Baseline (adaptation disabled)); skin: 90.2439% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.2761% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.4155% (minimum 99%, Baseline (adaptation disabled)); stomach: 91.2329% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.3126% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.5217% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,25,7.9,45.4,"thymus: 45.4 nTPM (manageable, limit 5); bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); rectum: 5.7 nTPM (protected, limit 2); colon: 4.7 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000112742,TTK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.526874,-0.161748,-0.418816
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.1184% (minimum 99%, Missing); cerebral cortex: 98.8131% (minimum 99%, Missing); colon: 87.6316% (minimum 97%, Missing); duodenum: 89.5161% (minimum 99%, Missing); esophagus: 87.8628% (minimum 97%, Missing); lung: 97.6540% (minimum 99%, Missing); lymph node: 80.8252% (minimum 97%, Missing); rectum: 85.3846% (minimum 97%, Missing); retina: 94.8718% (minimum 99%, Missing); skin: 90.2439% (minimum 95%, Missing); small intestine: 89.2761% (minimum 99%, Missing); stomach: 91.2329% (minimum 97%, Missing); thymus: 42.3126% (minimum 95%, Missing); urinary bladder: 96.5217% (minimum 97%, Missing)",0,1,partial,25,7.9,45.4,"thymus: 45.4 nTPM (manageable, limit 5); bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); rectum: 5.7 nTPM (protected, limit 2); colon: 4.7 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000112742,TTK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.526874,-0.161748,-0.418816
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.1,0.3,1.8,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000112761,CCN6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.0588% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.2857% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.1538% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.0588% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.0588% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.0588% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1165% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 93.3962% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.0588% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.0588% (minimum 99%, Baseline (adaptation disabled)); skin: 84.6154% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.0198% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.1165% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.1,0.3,1.8,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000112761,CCN6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.103846,0.000588235,-0.228462
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.0588% (minimum 99%, Missing); basal ganglia: 94.2857% (minimum 99%, Missing); cerebellum: 76.1538% (minimum 99%, Missing); cerebral cortex: 97.0588% (minimum 99%, Missing); heart muscle: 97.0588% (minimum 99%, Missing); hippocampal formation: 97.0588% (minimum 99%, Missing); hypothalamus: 96.1165% (minimum 99%, Missing); kidney: 90.0000% (minimum 99%, Missing); liver: 93.3962% (minimum 99%, Missing); midbrain: 97.0588% (minimum 99%, Missing); pituitary gland: 97.0588% (minimum 99%, Missing); skin: 84.6154% (minimum 95%, Missing); small intestine: 98.0198% (minimum 99%, Missing); spinal cord: 96.1165% (minimum 99%, Missing)",0,80,unavailable,3.1,0.3,1.8,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000112761,CCN6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.103846,0.000588235,-0.228462
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,29.7,44.7,49.5,"thyroid gland: 49.5 nTPM (manageable, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 2); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 2); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); pancreas: 9.4 nTPM (vital, limit 6); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 2); heart muscle: 4.3 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000112796,ENPP5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.5895% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.4601% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.5112% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.1417% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.3673% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.5895% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2246% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.4201% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.2768% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.0448% (minimum 99%, Baseline (adaptation disabled)); lung: 96.5503% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.8832% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.1989% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.1826% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.4961% (minimum 99%, Baseline (adaptation disabled)); retina: 88.9013% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.4797% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.8501% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.6200% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 82.7766% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.0048% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,29.7,44.7,49.5,"thyroid gland: 49.5 nTPM (manageable, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 2); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 2); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); pancreas: 9.4 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 2); heart muscle: 4.3 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000112796,ENPP5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.122234,-0.128174,-0.100987
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.5895% (minimum 99%, Missing); amygdala: 97.4601% (minimum 99%, Missing); basal ganglia: 96.5112% (minimum 99%, Missing); cerebellum: 97.1417% (minimum 99%, Missing); cerebral cortex: 94.3673% (minimum 99%, Missing); choroid plexus: 96.5895% (minimum 99%, Missing); heart muscle: 98.2246% (minimum 99%, Missing); hippocampal formation: 97.4201% (minimum 99%, Missing); hypothalamus: 96.2768% (minimum 99%, Missing); kidney: 91.0448% (minimum 99%, Missing); lung: 96.5503% (minimum 99%, Missing); midbrain: 93.8832% (minimum 99%, Missing); parathyroid gland: 84.1826% (minimum 97%, Missing); pituitary gland: 92.4961% (minimum 99%, Missing); retina: 88.9013% (minimum 99%, Missing); salivary gland: 94.4797% (minimum 97%, Missing); skeletal muscle: 95.8501% (minimum 99%, Missing); spinal cord: 97.6200% (minimum 99%, Missing); thyroid gland: 82.7766% (minimum 95%, Missing); tongue: 96.0048% (minimum 97%, Missing)",0,4,partial,29.7,44.7,49.5,"thyroid gland: 49.5 nTPM (manageable, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 2); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 2); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); pancreas: 9.4 nTPM (vital, limit 6); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 2); heart muscle: 4.3 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000112796,ENPP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.122234,-0.128174,-0.100987
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,4.4,2.2,2.6,"cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112852,PCDHB2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.0968% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.0769% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.8182% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.1818% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.8182% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 55.1020% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.1034% (minimum 99%, Baseline (adaptation disabled)); colon: 71.0526% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.7143% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.4118% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.0968% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.7143% (minimum 99%, Baseline (adaptation disabled)); liver: 96.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 72.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.4286% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.7143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.3750% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 76.0563% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.0968% (minimum 97%, Baseline (adaptation disabled)); retina: 80.5970% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.1429% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); skin: 73.9726% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.5970% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.5970% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.0968% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 80.5970% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.8182% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 81.8182% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,4.4,2.2,2.6,"cerebral cortex: 4.4 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112852,PCDHB2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.275,-0.259474,-0.43898
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 87.0968% (minimum 95%, Enhanced); amygdala: 83.0769% (minimum 99%, Missing); basal ganglia: 81.8182% (minimum 99%, Missing); cerebellum: 81.8182% (minimum 99%, Missing); cerebral cortex: 55.1020% (minimum 99%, Missing); choroid plexus: 93.1034% (minimum 99%, Missing); colon: 71.0526% (minimum 80%, Enhanced); duodenum: 90.0000% (minimum 95%, Enhanced); heart muscle: 75.0000% (minimum 95%, Enhanced); hippocampal formation: 79.4118% (minimum 99%, Missing); hypothalamus: 87.0968% (minimum 99%, Missing); kidney: 85.7143% (minimum 99%, Missing); lung: 72.0000% (minimum 99%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 84.3750% (minimum 95%, Enhanced); pituitary gland: 76.0563% (minimum 99%, Missing); retina: 80.5970% (minimum 99%, Missing); salivary gland: 77.1429% (minimum 80%, Enhanced); skeletal muscle: 85.7143% (minimum 95%, Enhanced); small intestine: 85.7143% (minimum 95%, Enhanced); smooth muscle: 80.5970% (minimum 95%, Enhanced); spinal cord: 80.5970% (minimum 99%, Missing); thyroid gland: 80.5970% (minimum 95%, Missing); tongue: 81.8182% (minimum 97%, Missing)",0,5,partial,4.4,2.2,2.6,"cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000112852,PCDHB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.14403,-0.151818,-0.43898
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,1.6,1.7,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000113205,PCDHB3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.3077% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.4681% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.3953% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.7778% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.3953% (minimum 99%, Baseline (adaptation disabled)); colon: 81.3953% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.1053% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.1053% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.0870% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.3659% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.3953% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.0870% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2222% (minimum 99%, Baseline (adaptation disabled)); lung: 77.7778% (minimum 99%, Baseline (adaptation disabled)); midbrain: 85.3659% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.0870% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.6275% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.3077% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 79.5455% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.3659% (minimum 99%, Baseline (adaptation disabled)); skin: 85.3659% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 77.7778% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.3953% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.7436% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.5000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 83.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.5455% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.7,1.6,1.7,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000113205,PCDHB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.276923,-0.283725,-0.316923
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.3077% (minimum 95%, Missing); adrenal gland: 74.4681% (minimum 99%, Missing); amygdala: 81.3953% (minimum 99%, Missing); basal ganglia: 77.7778% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 99%, Missing); cerebral cortex: 81.3953% (minimum 99%, Missing); colon: 81.3953% (minimum 97%, Missing); duodenum: 92.1053% (minimum 99%, Missing); esophagus: 92.1053% (minimum 97%, Missing); heart muscle: 76.0870% (minimum 99%, Missing); hippocampal formation: 85.3659% (minimum 99%, Missing); hypothalamus: 81.3953% (minimum 99%, Missing); kidney: 76.0870% (minimum 99%, Missing); liver: 97.2222% (minimum 99%, Missing); lung: 77.7778% (minimum 99%, Missing); midbrain: 85.3659% (minimum 99%, Missing); pancreas: 76.0870% (minimum 99%, Missing); parathyroid gland: 68.6275% (minimum 97%, Missing); pituitary gland: 67.3077% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 79.5455% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 85.3659% (minimum 99%, Missing); skin: 85.3659% (minimum 95%, Missing); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 77.7778% (minimum 99%, Missing); spinal cord: 81.3953% (minimum 99%, Missing); spleen: 89.7436% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thyroid gland: 83.3333% (minimum 95%, Missing); tongue: 79.5455% (minimum 97%, Missing); urinary bladder: 83.3333% (minimum 97%, Missing)",0,80,unavailable,1.7,1.6,1.7,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000113205,PCDHB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.276923,-0.283725,-0.316923
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,4.6,2.6,2.5,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000113209,PCDHB5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.8182% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.7468% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.2308% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.7500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.1650% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.3014% (minimum 99%, Baseline (adaptation disabled)); colon: 81.8182% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.9231% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.8293% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.2558% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.7468% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.2558% (minimum 99%, Baseline (adaptation disabled)); liver: 90.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 78.7500% (minimum 99%, Baseline (adaptation disabled)); midbrain: 80.7692% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.7982% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.7865% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.0213% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.4545% (minimum 97%, Baseline (adaptation disabled)); retina: 73.2558% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.1176% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.1351% (minimum 99%, Baseline (adaptation disabled)); skin: 91.3043% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.3043% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.9036% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.3014% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.0299% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.5909% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.3043% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.7692% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,4.6,2.6,2.5,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000113209,PCDHB5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.234091,-0.262135,-0.412018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.8182% (minimum 90%, Approved); adrenal gland: 79.7468% (minimum 98%, Approved); amygdala: 70.0000% (minimum 99%, Missing); basal ganglia: 69.2308% (minimum 99%, Missing); cerebellum: 78.7500% (minimum 99%, Missing); cerebral cortex: 61.1650% (minimum 99%, Missing); choroid plexus: 86.3014% (minimum 99%, Missing); colon: 81.8182% (minimum 97%, Missing); duodenum: 96.9231% (minimum 99%, Missing); esophagus: 90.0000% (minimum 95%, Approved); heart muscle: 76.8293% (minimum 99%, Missing); hippocampal formation: 73.2558% (minimum 99%, Missing); hypothalamus: 79.7468% (minimum 99%, Missing); kidney: 73.2558% (minimum 99%, Missing); liver: 90.0000% (minimum 98%, Approved); lung: 78.7500% (minimum 99%, Missing); midbrain: 80.7692% (minimum 99%, Missing); pancreas: 57.7982% (minimum 99%, Missing); parathyroid gland: 70.7865% (minimum 97%, Missing); pituitary gland: 67.0213% (minimum 99%, Missing); rectum: 95.4545% (minimum 97%, Missing); retina: 73.2558% (minimum 99%, Missing); salivary gland: 74.1176% (minimum 97%, Missing); skeletal muscle: 85.1351% (minimum 99%, Missing); skin: 91.3043% (minimum 95%, Missing); small intestine: 91.3043% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spinal cord: 75.9036% (minimum 99%, Missing); spleen: 90.0000% (minimum 95%, Missing); stomach: 86.3014% (minimum 97%, Missing); thymus: 94.0299% (minimum 95%, Missing); thyroid gland: 71.5909% (minimum 95%, Missing); tongue: 91.3043% (minimum 97%, Missing); urinary bladder: 80.7692% (minimum 97%, Missing)",0,3,partial,4.6,2.6,2.5,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000113209,PCDHB5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.234091,-0.262135,-0.412018
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.8,1.8,0.8,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000113211,PCDHB6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.3750% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.8824% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.5758% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.3514% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 73.0769% (minimum 97%, Baseline (adaptation disabled)); esophagus: 90.4762% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 73.0769% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 59.3750% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.0769% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 95.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 76.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.3704% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.1667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.3514% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 65.5172% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 67.8571% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.0769% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.3636% (minimum 99%, Baseline (adaptation disabled)); skin: 73.0769% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.3636% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.4762% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.3636% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 82.6087% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.3636% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.8,1.8,0.8,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000113211,PCDHB6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.246296,-0.456486,-0.476486
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Missing); adrenal gland: 76.0000% (minimum 99%, Missing); amygdala: 59.3750% (minimum 99%, Missing); basal ganglia: 55.8824% (minimum 99%, Missing); cerebellum: 57.5758% (minimum 99%, Missing); cerebral cortex: 51.3514% (minimum 99%, Missing); choroid plexus: 95.0000% (minimum 99%, Missing); colon: 73.0769% (minimum 97%, Missing); esophagus: 90.4762% (minimum 97%, Missing); heart muscle: 73.0769% (minimum 99%, Missing); hippocampal formation: 59.3750% (minimum 99%, Missing); hypothalamus: 73.0769% (minimum 99%, Missing); kidney: 76.0000% (minimum 99%, Missing); liver: 95.0000% (minimum 99%, Missing); lung: 76.0000% (minimum 99%, Missing); lymph node: 95.0000% (minimum 97%, Missing); midbrain: 70.3704% (minimum 99%, Missing); pancreas: 79.1667% (minimum 99%, Missing); parathyroid gland: 51.3514% (minimum 97%, Missing); pituitary gland: 65.5172% (minimum 99%, Missing); rectum: 95.0000% (minimum 97%, Missing); retina: 67.8571% (minimum 99%, Missing); salivary gland: 73.0769% (minimum 97%, Missing); skeletal muscle: 86.3636% (minimum 99%, Missing); skin: 73.0769% (minimum 95%, Missing); small intestine: 86.3636% (minimum 99%, Missing); smooth muscle: 67.8571% (minimum 99%, Missing); spinal cord: 63.3333% (minimum 99%, Missing); spleen: 90.4762% (minimum 95%, Missing); stomach: 86.3636% (minimum 97%, Missing); thyroid gland: 82.6087% (minimum 95%, Missing); tongue: 86.3636% (minimum 97%, Missing); urinary bladder: 76.0000% (minimum 97%, Missing)",0,80,unavailable,1.8,1.8,0.8,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000113211,PCDHB6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.246296,-0.456486,-0.476486
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,23.6,4.1,9.4,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); thymus: 9.4 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000113396,SLC27A6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 46.6063% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.2127% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.7928% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.3704% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.1698% (minimum 99%, Baseline (adaptation disabled)); colon: 96.2617% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.0952% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.4008% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 47.5751% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.9643% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.1775% (minimum 99%, Baseline (adaptation disabled)); lung: 96.2617% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.5556% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 77.7358% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.3767% (minimum 97%, Baseline (adaptation disabled)); retina: 74.1007% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.8333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.0952% (minimum 99%, Baseline (adaptation disabled)); skin: 91.5556% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.3704% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.2617% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.2308% (minimum 99%, Baseline (adaptation disabled)); thymus: 68.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.3767% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.2617% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.9309% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,23.6,4.1,9.4,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); thymus: 9.4 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000113396,SLC27A6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.263333,-0.135992,-0.523937
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 46.6063% (minimum 99%, Missing); amygdala: 93.2127% (minimum 99%, Missing); basal ganglia: 92.7928% (minimum 99%, Missing); cerebral cortex: 95.3704% (minimum 99%, Missing); choroid plexus: 97.1698% (minimum 99%, Missing); esophagus: 83.4008% (minimum 97%, Missing); heart muscle: 47.5751% (minimum 99%, Missing); hippocampal formation: 91.9643% (minimum 99%, Missing); hypothalamus: 89.1775% (minimum 99%, Missing); lung: 96.2617% (minimum 98%, Approved); midbrain: 91.5556% (minimum 99%, Missing); pituitary gland: 77.7358% (minimum 99%, Missing); rectum: 92.3767% (minimum 95%, Approved); retina: 74.1007% (minimum 99%, Missing); salivary gland: 85.8333% (minimum 95%, Approved); skeletal muscle: 98.0952% (minimum 99%, Missing); small intestine: 95.3704% (minimum 98%, Approved); smooth muscle: 96.2617% (minimum 99%, Missing); spinal cord: 79.2308% (minimum 99%, Missing); thymus: 68.6667% (minimum 95%, Missing); thyroid gland: 92.3767% (minimum 95%, Missing); tongue: 96.2617% (minimum 97%, Missing); urinary bladder: 94.9309% (minimum 95%, Approved)",0,4,partial,23.6,4.1,9.4,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); thymus: 9.4 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000113396,SLC27A6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.263333,-0.135992,-0.523937
True,compatible,,True,True,False,,0,6,partial,0.8,0.2,0.4,,,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,ENSG00000113525,IL5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.2308% (minimum 99%, Baseline (adaptation disabled)); duodenum: 90.7407% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.0784% (minimum 99%, Baseline (adaptation disabled)); liver: 96.0784% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 96.0784% (minimum 99%, Baseline (adaptation disabled)); small intestine: 85.9649% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.0000% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.0784% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.4528% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,0.8,0.2,0.4,,,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,ENSG00000113525,IL5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,-0.0254717,-0.00921569,-0.130351
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.0000% (minimum 99%, Missing); cerebral cortex: 94.2308% (minimum 98%, Approved); duodenum: 90.7407% (minimum 98%, Approved); heart muscle: 96.0784% (minimum 98%, Approved); liver: 96.0784% (minimum 98%, Approved); midbrain: 98.0000% (minimum 99%, Missing); retina: 96.0784% (minimum 99%, Missing); small intestine: 85.9649% (minimum 98%, Approved)",0,6,partial,0.8,0.2,0.4,,,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,ENSG00000113525,IL5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,0.0245283,0.01,-0.120351
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,36.8,12.3,5.3,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000113966,ARL6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.3878% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.6271% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.3853% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 53.1250% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.4737% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.1429% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 46.5753% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.8333% (minimum 99%, Baseline (adaptation disabled)); colon: 74.7253% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.1031% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.3267% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.6271% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 57.6271% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.2270% (minimum 99%, Baseline (adaptation disabled)); liver: 73.1183% (minimum 99%, Baseline (adaptation disabled)); lung: 58.1197% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.7253% (minimum 97%, Baseline (adaptation disabled)); midbrain: 65.3846% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.3267% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 35.6021% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.9630% (minimum 99%, Baseline (adaptation disabled)); rectum: 73.9130% (minimum 97%, Baseline (adaptation disabled)); retina: 15.5963% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 54.8387% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.9268% (minimum 99%, Baseline (adaptation disabled)); skin: 70.8333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.3853% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.6869% (minimum 99%, Baseline (adaptation disabled)); spleen: 71.5789% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.8333% (minimum 97%, Baseline (adaptation disabled)); thymus: 74.7253% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.1983% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.4045% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.6869% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,36.8,12.3,5.3,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000113966,ARL6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.388017,-0.613979,-0.834037
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.3878% (minimum 90%, Approved); adrenal gland: 57.6271% (minimum 99%, Missing); amygdala: 62.3853% (minimum 99%, Missing); basal ganglia: 53.1250% (minimum 99%, Missing); bone marrow: 89.4737% (minimum 99%, Missing); cerebellum: 57.1429% (minimum 99%, Missing); cerebral cortex: 46.5753% (minimum 99%, Missing); choroid plexus: 70.8333% (minimum 99%, Missing); colon: 74.7253% (minimum 97%, Missing); duodenum: 85.0000% (minimum 99%, Missing); esophagus: 70.1031% (minimum 97%, Missing); heart muscle: 67.3267% (minimum 99%, Missing); hippocampal formation: 57.6271% (minimum 99%, Missing); hypothalamus: 57.6271% (minimum 99%, Missing); kidney: 48.2270% (minimum 99%, Missing); liver: 73.1183% (minimum 99%, Missing); lung: 58.1197% (minimum 99%, Missing); lymph node: 74.7253% (minimum 97%, Missing); midbrain: 65.3846% (minimum 99%, Missing); pancreas: 67.3267% (minimum 99%, Missing); parathyroid gland: 35.6021% (minimum 97%, Missing); pituitary gland: 62.9630% (minimum 99%, Missing); rectum: 73.9130% (minimum 97%, Missing); retina: 15.5963% (minimum 99%, Missing); salivary gland: 54.8387% (minimum 97%, Missing); skeletal muscle: 82.9268% (minimum 99%, Missing); skin: 70.8333% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 62.3853% (minimum 99%, Missing); spinal cord: 68.6869% (minimum 99%, Missing); spleen: 71.5789% (minimum 95%, Missing); stomach: 70.8333% (minimum 97%, Missing); thymus: 74.7253% (minimum 95%, Missing); thyroid gland: 56.1983% (minimum 95%, Missing); tongue: 76.4045% (minimum 97%, Missing); urinary bladder: 68.6869% (minimum 97%, Missing)",0,2,partial,36.8,12.3,5.3,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000113966,ARL6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.388017,-0.613979,-0.834037
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,59.8,33.4,21.6,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 2); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); urinary bladder: 21.4 nTPM (protected, limit 2); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 4); thyroid gland: 20.7 nTPM (manageable, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 2); esophagus: 20.3 nTPM (protected, limit 2); adipose tissue: 20.1 nTPM (manageable, limit 10); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 2); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 2); colon: 16.3 nTPM (protected, limit 2); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); spleen: 15.5 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); midbrain: 14.5 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); skin: 12.4 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000114098,ARMC8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.7245% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.8788% (minimum 99%, Baseline (adaptation disabled)); amygdala: 57.7039% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.4098% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 24.2079% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 33.3916% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 45.5847% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 47.1605% (minimum 99%, Baseline (adaptation disabled)); colon: 53.9548% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.0130% (minimum 99%, Baseline (adaptation disabled)); esophagus: 48.4772% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 53.2033% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.7039% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 52.3288% (minimum 99%, Baseline (adaptation disabled)); kidney: 51.2064% (minimum 99%, Baseline (adaptation disabled)); liver: 53.8028% (minimum 99%, Baseline (adaptation disabled)); lung: 54.7278% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.9899% (minimum 97%, Baseline (adaptation disabled)); midbrain: 56.8452% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.0547% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 48.1108% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.4148% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.7615% (minimum 97%, Baseline (adaptation disabled)); retina: 42.9213% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.0224% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 33.8053% (minimum 99%, Baseline (adaptation disabled)); skin: 60.6349% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.3168% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 44.8357% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 54.5714% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.2023% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.0117% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.9287% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 47.9899% (minimum 95%, Baseline (adaptation disabled)); tongue: 36.3810% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 47.1605% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,59.8,33.4,21.6,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 2); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); urinary bladder: 21.4 nTPM (protected, limit 2); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); thyroid gland: 20.7 nTPM (manageable, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 2); esophagus: 20.3 nTPM (protected, limit 2); adipose tissue: 20.1 nTPM (manageable, limit 5); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 2); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 1); colon: 16.3 nTPM (protected, limit 2); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); spleen: 15.5 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); midbrain: 14.5 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); skin: 12.4 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000114098,ARMC8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.480713,-0.60619,-0.747921
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.7245% (minimum 90%, Approved); adrenal gland: 57.8788% (minimum 99%, Missing); amygdala: 57.7039% (minimum 99%, Missing); basal ganglia: 58.4098% (minimum 99%, Missing); bone marrow: 24.2079% (minimum 99%, Missing); cerebellum: 33.3916% (minimum 99%, Missing); cerebral cortex: 45.5847% (minimum 99%, Missing); choroid plexus: 47.1605% (minimum 99%, Missing); colon: 53.9548% (minimum 97%, Missing); duodenum: 62.0130% (minimum 99%, Missing); esophagus: 48.4772% (minimum 97%, Missing); heart muscle: 53.2033% (minimum 99%, Missing); hippocampal formation: 57.7039% (minimum 99%, Missing); hypothalamus: 52.3288% (minimum 99%, Missing); kidney: 51.2064% (minimum 99%, Missing); liver: 53.8028% (minimum 98%, Approved); lung: 54.7278% (minimum 99%, Missing); lymph node: 47.9899% (minimum 95%, Approved); midbrain: 56.8452% (minimum 99%, Missing); pancreas: 58.0547% (minimum 99%, Missing); parathyroid gland: 48.1108% (minimum 97%, Missing); pituitary gland: 61.4148% (minimum 99%, Missing); rectum: 51.7615% (minimum 97%, Missing); retina: 42.9213% (minimum 99%, Missing); salivary gland: 61.0224% (minimum 97%, Missing); skeletal muscle: 33.8053% (minimum 99%, Missing); skin: 60.6349% (minimum 95%, Missing); small intestine: 59.3168% (minimum 99%, Missing); smooth muscle: 44.8357% (minimum 99%, Missing); spinal cord: 54.5714% (minimum 99%, Missing); spleen: 55.2023% (minimum 95%, Missing); stomach: 56.0117% (minimum 97%, Missing); thymus: 46.9287% (minimum 95%, Missing); thyroid gland: 47.9899% (minimum 95%, Missing); tongue: 36.3810% (minimum 97%, Missing); urinary bladder: 47.1605% (minimum 97%, Missing)",0,6,partial,59.8,33.4,21.6,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 2); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); urinary bladder: 21.4 nTPM (protected, limit 2); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 4); thyroid gland: 20.7 nTPM (manageable, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 2); esophagus: 20.3 nTPM (protected, limit 2); adipose tissue: 20.1 nTPM (manageable, limit 10); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 2); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 2); colon: 16.3 nTPM (protected, limit 2); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); spleen: 15.5 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); midbrain: 14.5 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); skin: 12.4 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000114098,ARMC8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.480713,-0.60619,-0.747921
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,1086,0.2,0.4,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000114349,GNAT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.3077% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.3077% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.1579% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.7143% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.3077% (minimum 99%, Baseline (adaptation disabled)); colon: 92.3077% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.3077% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.7143% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 92.3077% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.3077% (minimum 99%, Baseline (adaptation disabled)); liver: 92.3077% (minimum 99%, Baseline (adaptation disabled)); lung: 92.3077% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.3077% (minimum 97%, Baseline (adaptation disabled)); parathyroid gland: 92.3077% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.3077% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.7143% (minimum 97%, Baseline (adaptation disabled)); retina: 0.1104% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 92.3077% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.3077% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.3077% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.3077% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.3077% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.3077% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.3077% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.3077% (minimum 95%, Baseline (adaptation disabled))",0,0,routine_complete,1086,0.2,0.4,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000114349,GNAT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.2,-0.112857,-0.988896
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.3077% (minimum 95%, Enhanced); bone marrow: 63.1579% (minimum 95%, Enhanced); cerebral cortex: 85.7143% (minimum 95%, Enhanced); choroid plexus: 92.3077% (minimum 99%, Missing); duodenum: 92.3077% (minimum 95%, Enhanced); hippocampal formation: 92.3077% (minimum 99%, Missing); kidney: 92.3077% (minimum 95%, Enhanced); liver: 92.3077% (minimum 95%, Enhanced); lung: 92.3077% (minimum 95%, Enhanced); pituitary gland: 92.3077% (minimum 99%, Missing); retina: 0.1104% (minimum 99%, Missing); skeletal muscle: 92.3077% (minimum 95%, Enhanced); small intestine: 92.3077% (minimum 95%, Enhanced); smooth muscle: 92.3077% (minimum 95%, Enhanced); spinal cord: 92.3077% (minimum 99%, Missing); thymus: 92.3077% (minimum 95%, Missing)",0,0,routine_complete,1086,0.2,0.4,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000114349,GNAT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.0269231,0.03,-0.988896
True,compatible,,True,True,False,,0,1,partial,0.3,0.1,0,,,54,not_established,not_triggered,,,ENSG00000114487,MORC1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hippocampal formation: 98.7261% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.1013% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.3,0.1,0,,,54,not_established,not_triggered,,,ENSG00000114487,MORC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.0235897,-0.00898734
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hippocampal formation: 98.7261% (minimum 99%, Missing); pituitary gland: 98.1013% (minimum 99%, Missing)",0,1,partial,0.3,0.1,0,,,54,not_established,not_triggered,,,ENSG00000114487,MORC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,-0.00898734
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,2.9,14.1,6.8,"salivary gland: 14.1 nTPM (protected, limit 6); basal ganglia: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000114547,ROPN1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.6269% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.6269% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.6269% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.6601% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,2.9,14.1,6.8,"salivary gland: 14.1 nTPM (protected, limit 2); skin: 6.8 nTPM (manageable, limit 5); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000114547,ROPN1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0183868,-0.0333993,-0.00373106
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.6269% (minimum 99%, Missing); pituitary gland: 98.6269% (minimum 99%, Missing)",0,3,partial,2.9,14.1,6.8,"salivary gland: 14.1 nTPM (protected, limit 6); basal ganglia: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000114547,ROPN1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.0261741,-0.00373106
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.5,1.6,4.2,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000114656,CFAP92,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.8326% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.2727% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.9641% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.0638% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6175% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.1111% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.6255% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.3964% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.1111% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.2727% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.3964% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.3964% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.1651% (minimum 99%, Baseline (adaptation disabled)); lung: 95.1111% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.5357% (minimum 97%, Baseline (adaptation disabled)); pancreas: 95.9641% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.0435% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.6407% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.8326% (minimum 97%, Baseline (adaptation disabled)); retina: 88.4298% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.8326% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.8326% (minimum 99%, Baseline (adaptation disabled)); skin: 83.5938% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.9641% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.5357% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.2520% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,4.5,1.6,4.2,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000114656,CFAP92,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,-0.114062,-0.0395652,-0.163745
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.8326% (minimum 99%, Missing); amygdala: 97.2727% (minimum 99%, Missing); basal ganglia: 95.9641% (minimum 99%, Missing); bone marrow: 91.0638% (minimum 99%, Missing); cerebellum: 98.6175% (minimum 99%, Missing); cerebral cortex: 95.1111% (minimum 99%, Missing); choroid plexus: 82.6255% (minimum 99%, Missing); duodenum: 96.3964% (minimum 99%, Missing); esophagus: 95.1111% (minimum 97%, Missing); heart muscle: 97.2727% (minimum 99%, Missing); hippocampal formation: 96.3964% (minimum 99%, Missing); hypothalamus: 96.3964% (minimum 99%, Missing); kidney: 98.1651% (minimum 99%, Missing); lung: 95.1111% (minimum 99%, Missing); lymph node: 95.5357% (minimum 97%, Missing); pancreas: 95.9641% (minimum 99%, Missing); parathyroid gland: 93.0435% (minimum 97%, Missing); pituitary gland: 92.6407% (minimum 99%, Missing); rectum: 96.8326% (minimum 97%, Missing); retina: 88.4298% (minimum 99%, Missing); salivary gland: 96.8326% (minimum 97%, Missing); skeletal muscle: 96.8326% (minimum 99%, Missing); skin: 83.5938% (minimum 95%, Missing); small intestine: 95.9641% (minimum 99%, Missing); stomach: 95.5357% (minimum 97%, Missing); thymus: 84.2520% (minimum 95%, Missing)",0,80,unavailable,4.5,1.6,4.2,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000114656,CFAP92,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,-0.114062,-0.0395652,-0.163745
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,6.3,3.2,4,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 2); cerebellum: 4.8 nTPM (vital, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); liver: 2.2 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000114739,ACVR2B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 48.0769% (minimum 99%, Baseline (adaptation disabled)); amygdala: 55.5556% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 59.5238% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.5926% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 34.2466% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.0204% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.1250% (minimum 99%, Baseline (adaptation disabled)); colon: 64.1026% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.7576% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.1250% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.7895% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 59.5238% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 56.8182% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.5238% (minimum 99%, Baseline (adaptation disabled)); liver: 53.1915% (minimum 99%, Baseline (adaptation disabled)); lung: 67.5676% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.1250% (minimum 97%, Baseline (adaptation disabled)); midbrain: 60.9756% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.0204% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 43.8596% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.4444% (minimum 97%, Baseline (adaptation disabled)); retina: 28.4091% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.5238% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 30.1205% (minimum 99%, Baseline (adaptation disabled)); skin: 78.1250% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.4444% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.5294% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 58.1395% (minimum 99%, Baseline (adaptation disabled)); spleen: 71.4286% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.5000% (minimum 97%, Baseline (adaptation disabled)); thymus: 38.4615% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.5000% (minimum 95%, Baseline (adaptation disabled)); tongue: 48.0769% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.1026% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,6.3,3.2,4,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000114739,ACVR2B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.565385,-0.531404,-0.705909
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4286% (minimum 90%, Approved); adrenal gland: 48.0769% (minimum 99%, Missing); amygdala: 55.5556% (minimum 99%, Missing); basal ganglia: 59.5238% (minimum 99%, Missing); bone marrow: 92.5926% (minimum 99%, Missing); cerebellum: 34.2466% (minimum 98%, Approved); cerebral cortex: 51.0204% (minimum 98%, Approved); choroid plexus: 78.1250% (minimum 99%, Missing); colon: 64.1026% (minimum 97%, Missing); duodenum: 75.7576% (minimum 99%, Missing); esophagus: 78.1250% (minimum 97%, Missing); heart muscle: 65.7895% (minimum 99%, Missing); hippocampal formation: 59.5238% (minimum 99%, Missing); hypothalamus: 56.8182% (minimum 99%, Missing); kidney: 59.5238% (minimum 99%, Missing); liver: 53.1915% (minimum 98%, Approved); lung: 67.5676% (minimum 98%, Approved); lymph node: 78.1250% (minimum 95%, Approved); midbrain: 60.9756% (minimum 99%, Missing); pancreas: 51.0204% (minimum 99%, Missing); parathyroid gland: 43.8596% (minimum 97%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); rectum: 69.4444% (minimum 97%, Missing); retina: 28.4091% (minimum 99%, Missing); salivary gland: 59.5238% (minimum 95%, Approved); skeletal muscle: 30.1205% (minimum 98%, Approved); skin: 78.1250% (minimum 95%, Missing); small intestine: 69.4444% (minimum 99%, Missing); smooth muscle: 73.5294% (minimum 99%, Missing); spinal cord: 58.1395% (minimum 99%, Missing); spleen: 71.4286% (minimum 90%, Approved); stomach: 62.5000% (minimum 97%, Missing); thymus: 38.4615% (minimum 95%, Missing); thyroid gland: 62.5000% (minimum 95%, Missing); tongue: 48.0769% (minimum 97%, Missing); urinary bladder: 64.1026% (minimum 97%, Missing)",0,3,partial,6.3,3.2,4,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 2); cerebellum: 4.8 nTPM (vital, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); liver: 2.2 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000114739,ACVR2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.565385,-0.531404,-0.705909
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,48.8,29.2,2.6,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 2); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 6); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; thymus,ENSG00000114757,PEX5L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.0370% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 24.7368% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 27.3256% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 69.1176% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 10.6576% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.3333% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.9167% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.9184% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 15.9864% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 28.4848% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.9167% (minimum 99%, Baseline (adaptation disabled)); lung: 97.9167% (minimum 99%, Baseline (adaptation disabled)); midbrain: 14.9682% (minimum 99%, Baseline (adaptation disabled)); pancreas: 32.1918% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 13.8643% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 47.9592% (minimum 99%, Baseline (adaptation disabled)); retina: 24.1026% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.9184% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.3333% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.9167% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 8.7850% (minimum 99%, Baseline (adaptation disabled)); thymus: 64.3836% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.0000% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,48.8,29.2,2.6,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 2); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; thymus,ENSG00000114757,PEX5L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.306164,-0.831357,-0.90215
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.0000% (minimum 99%, Missing); amygdala: 24.7368% (minimum 99%, Missing); basal ganglia: 27.3256% (minimum 99%, Missing); cerebellum: 69.1176% (minimum 99%, Missing); cerebral cortex: 10.6576% (minimum 99%, Missing); choroid plexus: 78.3333% (minimum 99%, Missing); duodenum: 97.9167% (minimum 99%, Missing); heart muscle: 95.9184% (minimum 99%, Missing); hippocampal formation: 15.9864% (minimum 99%, Missing); hypothalamus: 28.4848% (minimum 99%, Missing); kidney: 97.9167% (minimum 99%, Missing); lung: 97.9167% (minimum 99%, Missing); midbrain: 14.9682% (minimum 99%, Missing); pancreas: 32.1918% (minimum 95%, Enhanced); parathyroid gland: 13.8643% (minimum 97%, Missing); pituitary gland: 47.9592% (minimum 99%, Missing); retina: 24.1026% (minimum 99%, Missing); salivary gland: 95.9184% (minimum 97%, Missing); skeletal muscle: 78.3333% (minimum 95%, Enhanced); small intestine: 97.9167% (minimum 99%, Missing); spinal cord: 8.7850% (minimum 99%, Missing); thymus: 64.3836% (minimum 95%, Missing); tongue: 94.0000% (minimum 97%, Missing)",0,3,partial,48.8,29.2,2.6,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 2); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 6); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; thymus,ENSG00000114757,PEX5L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.306164,-0.831357,-0.90215
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,8,partial,32.7,20.3,12.7,"skeletal muscle: 32.7 nTPM (vital, limit 2); tongue: 20.3 nTPM (protected, limit 2); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 2); thymus: 12.7 nTPM (manageable, limit 5); urinary bladder: 12.6 nTPM (protected, limit 4); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); small intestine: 11.6 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 10); colon: 11.4 nTPM (protected, limit 2); skin: 10.5 nTPM (manageable, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 2); spleen: 9.9 nTPM (manageable, limit 5); lung: 9.6 nTPM (vital, limit 1); adrenal gland: 9.6 nTPM (vital, limit 1); pancreas: 9.5 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 2); esophagus: 8.6 nTPM (protected, limit 2); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 2); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000114982,KANSL3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9846% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.1660% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.3023% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.1105% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.6575% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.7321% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.1296% (minimum 99%, Baseline (adaptation disabled)); colon: 55.9846% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.4419% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.7706% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.4677% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.8263% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.8263% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.7706% (minimum 99%, Baseline (adaptation disabled)); liver: 70.0483% (minimum 99%, Baseline (adaptation disabled)); lung: 60.1660% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.4444% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.4167% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.8282% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.0435% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.7204% (minimum 97%, Baseline (adaptation disabled)); retina: 70.3883% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 54.3071% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 30.7203% (minimum 99%, Baseline (adaptation disabled)); skin: 58.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.5556% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.7045% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.7988% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.4262% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.4167% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.3088% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.7037% (minimum 95%, Baseline (adaptation disabled)); tongue: 41.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.5055% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,32.7,20.3,12.7,"skeletal muscle: 32.7 nTPM (vital, limit 1); tongue: 20.3 nTPM (protected, limit 2); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 2); thymus: 12.7 nTPM (manageable, limit 5); urinary bladder: 12.6 nTPM (protected, limit 2); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); small intestine: 11.6 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); colon: 11.4 nTPM (protected, limit 2); skin: 10.5 nTPM (manageable, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 1); spleen: 9.9 nTPM (manageable, limit 5); lung: 9.6 nTPM (vital, limit 1); adrenal gland: 9.6 nTPM (vital, limit 1); pancreas: 9.5 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 2); esophagus: 8.6 nTPM (protected, limit 2); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 2); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000114982,KANSL3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.416912,-0.553333,-0.682797
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9846% (minimum 90%, Approved); adrenal gland: 60.1660% (minimum 99%, Missing); amygdala: 84.3023% (minimum 99%, Missing); basal ganglia: 80.1105% (minimum 99%, Missing); bone marrow: 49.6575% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 99%, Missing); cerebral cortex: 64.7321% (minimum 99%, Missing); choroid plexus: 67.1296% (minimum 99%, Missing); colon: 55.9846% (minimum 97%, Missing); duodenum: 67.4419% (minimum 99%, Missing); esophagus: 62.7706% (minimum 97%, Missing); heart muscle: 58.4677% (minimum 99%, Missing); hippocampal formation: 86.8263% (minimum 99%, Missing); hypothalamus: 86.8263% (minimum 99%, Missing); kidney: 62.7706% (minimum 99%, Missing); liver: 70.0483% (minimum 99%, Missing); lung: 60.1660% (minimum 99%, Missing); lymph node: 64.4444% (minimum 97%, Missing); midbrain: 83.3333% (minimum 99%, Missing); pancreas: 60.4167% (minimum 99%, Missing); parathyroid gland: 49.8282% (minimum 97%, Missing); pituitary gland: 63.0435% (minimum 99%, Missing); rectum: 68.7204% (minimum 97%, Missing); retina: 70.3883% (minimum 99%, Missing); salivary gland: 54.3071% (minimum 97%, Missing); skeletal muscle: 30.7203% (minimum 98%, Approved); skin: 58.0000% (minimum 95%, Missing); small intestine: 55.5556% (minimum 99%, Missing); smooth muscle: 58.7045% (minimum 98%, Approved); spinal cord: 85.7988% (minimum 99%, Missing); spleen: 59.4262% (minimum 95%, Missing); stomach: 60.4167% (minimum 97%, Missing); thymus: 53.3088% (minimum 95%, Missing); thyroid gland: 53.7037% (minimum 95%, Missing); tongue: 41.6667% (minimum 97%, Missing); urinary bladder: 53.5055% (minimum 95%, Approved)",0,8,partial,32.7,20.3,12.7,"skeletal muscle: 32.7 nTPM (vital, limit 2); tongue: 20.3 nTPM (protected, limit 2); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 2); thymus: 12.7 nTPM (manageable, limit 5); urinary bladder: 12.6 nTPM (protected, limit 4); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); small intestine: 11.6 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 10); colon: 11.4 nTPM (protected, limit 2); skin: 10.5 nTPM (manageable, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 2); spleen: 9.9 nTPM (manageable, limit 5); lung: 9.6 nTPM (vital, limit 1); adrenal gland: 9.6 nTPM (vital, limit 1); pancreas: 9.5 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 2); esophagus: 8.6 nTPM (protected, limit 2); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 2); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000114982,KANSL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.416912,-0.553333,-0.672797
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.3,25,0.8,"urinary bladder: 25 nTPM (protected, limit 2); esophagus: 12.9 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000115008,IL1A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.1154% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0583% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.9910% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.9910% (minimum 99%, Baseline (adaptation disabled)); esophagus: 43.9130% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 98.0583% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1905% (minimum 99%, Baseline (adaptation disabled)); lung: 81.4516% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.2830% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.1905% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.0583% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.3805% (minimum 97%, Baseline (adaptation disabled)); skin: 92.6606% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 94.3925% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 28.7749% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.3,25,0.8,"urinary bladder: 25 nTPM (protected, limit 2); esophagus: 12.9 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000115008,IL1A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0233945,-0.682251,-0.175484
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.1154% (minimum 99%, Missing); basal ganglia: 98.0583% (minimum 99%, Missing); bone marrow: 90.9910% (minimum 99%, Missing); cerebral cortex: 90.9910% (minimum 99%, Missing); esophagus: 43.9130% (minimum 97%, Missing); hippocampal formation: 98.0583% (minimum 99%, Missing); hypothalamus: 96.1905% (minimum 99%, Missing); lung: 81.4516% (minimum 99%, Missing); midbrain: 95.2830% (minimum 99%, Missing); parathyroid gland: 96.1905% (minimum 97%, Missing); pituitary gland: 98.0583% (minimum 99%, Missing); salivary gland: 89.3805% (minimum 97%, Missing); skin: 92.6606% (minimum 95%, Missing); spinal cord: 94.3925% (minimum 99%, Missing); urinary bladder: 28.7749% (minimum 97%, Missing)",0,80,unavailable,2.3,25,0.8,"urinary bladder: 25 nTPM (protected, limit 2); esophagus: 12.9 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000115008,IL1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0233945,-0.682251,-0.175484
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,8,partial,23.8,19.8,12.1,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 2); esophagus: 19.7 nTPM (protected, limit 2); colon: 18 nTPM (protected, limit 2); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 2); stomach: 17 nTPM (protected, limit 2); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); salivary gland: 14.5 nTPM (protected, limit 2); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 2); tongue: 13.7 nTPM (protected, limit 2); bone marrow: 13.2 nTPM (vital, limit 1); skin: 12.1 nTPM (manageable, limit 5); thyroid gland: 11.9 nTPM (manageable, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); spleen: 8.3 nTPM (manageable, limit 5); adipose tissue: 7.9 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 2); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115159,GPD2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.0196% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.1905% (minimum 99%, Baseline (adaptation disabled)); amygdala: 54.1538% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 52.2255% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 57.1429% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 49.8584% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.9877% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.8605% (minimum 99%, Baseline (adaptation disabled)); colon: 49.4382% (minimum 97%, Baseline (adaptation disabled)); duodenum: 55.6962% (minimum 99%, Baseline (adaptation disabled)); esophagus: 47.1850% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.5763% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.6584% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.7059% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.5652% (minimum 99%, Baseline (adaptation disabled)); liver: 84.2105% (minimum 99%, Baseline (adaptation disabled)); lung: 61.3240% (minimum 99%, Baseline (adaptation disabled)); lymph node: 72.1311% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.7273% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 47.0588% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.8559% (minimum 99%, Baseline (adaptation disabled)); rectum: 50.2857% (minimum 97%, Baseline (adaptation disabled)); retina: 65.4275% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 54.8287% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 42.5121% (minimum 99%, Baseline (adaptation disabled)); skin: 59.2593% (minimum 95%, Baseline (adaptation disabled)); small intestine: 53.4954% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 74.8936% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.8367% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.9537% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.8671% (minimum 97%, Baseline (adaptation disabled)); thymus: 74.8936% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.6610% (minimum 95%, Baseline (adaptation disabled)); tongue: 56.2300% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.0510% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,23.8,19.8,12.1,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 2); esophagus: 19.7 nTPM (protected, limit 2); colon: 18 nTPM (protected, limit 2); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 2); stomach: 17 nTPM (protected, limit 2); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); salivary gland: 14.5 nTPM (protected, limit 2); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 2); tongue: 13.7 nTPM (protected, limit 2); bone marrow: 13.2 nTPM (vital, limit 1); skin: 12.1 nTPM (manageable, limit 5); thyroid gland: 11.9 nTPM (manageable, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); spleen: 8.3 nTPM (manageable, limit 5); adipose tissue: 7.9 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 2); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115159,GPD2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.357407,-0.499412,-0.564879
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.0196% (minimum 95%, Missing); adrenal gland: 76.1905% (minimum 99%, Missing); amygdala: 54.1538% (minimum 99%, Missing); basal ganglia: 52.2255% (minimum 99%, Missing); bone marrow: 57.1429% (minimum 99%, Missing); cerebellum: 49.8584% (minimum 99%, Missing); cerebral cortex: 53.9877% (minimum 99%, Missing); choroid plexus: 81.8605% (minimum 99%, Missing); colon: 49.4382% (minimum 97%, Missing); duodenum: 55.6962% (minimum 99%, Missing); esophagus: 47.1850% (minimum 97%, Missing); heart muscle: 74.5763% (minimum 99%, Missing); hippocampal formation: 54.6584% (minimum 99%, Missing); hypothalamus: 64.7059% (minimum 99%, Missing); kidney: 69.5652% (minimum 99%, Missing); liver: 84.2105% (minimum 99%, Missing); lung: 61.3240% (minimum 99%, Missing); lymph node: 72.1311% (minimum 97%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 72.7273% (minimum 99%, Missing); parathyroid gland: 47.0588% (minimum 97%, Missing); pituitary gland: 76.8559% (minimum 99%, Missing); rectum: 50.2857% (minimum 97%, Missing); retina: 65.4275% (minimum 99%, Missing); salivary gland: 54.8287% (minimum 97%, Missing); skeletal muscle: 42.5121% (minimum 99%, Missing); skin: 59.2593% (minimum 95%, Missing); small intestine: 53.4954% (minimum 99%, Missing); smooth muscle: 74.8936% (minimum 99%, Missing); spinal cord: 71.8367% (minimum 99%, Missing); spleen: 67.9537% (minimum 95%, Missing); stomach: 50.8671% (minimum 97%, Missing); thymus: 74.8936% (minimum 95%, Missing); thyroid gland: 59.6610% (minimum 95%, Missing); tongue: 56.2300% (minimum 97%, Missing); urinary bladder: 56.0510% (minimum 97%, Missing)",0,8,partial,23.8,19.8,12.1,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 2); esophagus: 19.7 nTPM (protected, limit 2); colon: 18 nTPM (protected, limit 2); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 2); stomach: 17 nTPM (protected, limit 2); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); salivary gland: 14.5 nTPM (protected, limit 2); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 2); tongue: 13.7 nTPM (protected, limit 2); bone marrow: 13.2 nTPM (vital, limit 1); skin: 12.1 nTPM (manageable, limit 5); thyroid gland: 11.9 nTPM (manageable, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); spleen: 8.3 nTPM (manageable, limit 5); adipose tissue: 7.9 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 2); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115159,GPD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.357407,-0.499412,-0.564879
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,11,partial,4,7.2,13,"thymus: 13 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115163,CENPA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 37.2881% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 43.1373% (minimum 97%, Baseline (adaptation disabled)); duodenum: 35.4839% (minimum 99%, Baseline (adaptation disabled)); esophagus: 38.5965% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.6522% (minimum 99%, Baseline (adaptation disabled)); liver: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 84.6154% (minimum 99%, Baseline (adaptation disabled)); lymph node: 23.4043% (minimum 97%, Baseline (adaptation disabled)); pancreas: 95.6522% (minimum 99%, Baseline (adaptation disabled)); rectum: 45.8333% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 78.5714% (minimum 97%, Baseline (adaptation disabled)); skin: 38.5965% (minimum 95%, Baseline (adaptation disabled)); small intestine: 44.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.3810% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.8947% (minimum 97%, Baseline (adaptation disabled)); thymus: 14.4737% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 75.8621% (minimum 97%, Baseline (adaptation disabled))",0,11,partial,4,7.2,13,"thymus: 13 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115163,CENPA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.805263,-0.735957,-0.635161
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 88.0000% (minimum 95%, Enhanced); bone marrow: 37.2881% (minimum 99%, Missing); cerebral cortex: 91.6667% (minimum 95%, Enhanced); colon: 43.1373% (minimum 97%, Missing); duodenum: 35.4839% (minimum 99%, Missing); esophagus: 38.5965% (minimum 97%, Missing); heart muscle: 91.6667% (minimum 95%, Enhanced); kidney: 95.6522% (minimum 99%, Missing); liver: 91.6667% (minimum 95%, Enhanced); lung: 84.6154% (minimum 95%, Enhanced); lymph node: 23.4043% (minimum 97%, Missing); rectum: 45.8333% (minimum 97%, Missing); salivary gland: 78.5714% (minimum 80%, Enhanced); skin: 38.5965% (minimum 95%, Missing); small intestine: 44.0000% (minimum 99%, Missing); smooth muscle: 73.3333% (minimum 95%, Enhanced); spleen: 52.3810% (minimum 95%, Missing); stomach: 57.8947% (minimum 97%, Missing); thymus: 14.4737% (minimum 95%, Missing); urinary bladder: 75.8621% (minimum 97%, Missing)",0,11,partial,4,7.2,13,"thymus: 13 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 2); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115163,CENPA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.805263,-0.735957,-0.635161
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,28.8,0.5,0.2,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 6)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen,ENSG00000115194,SLC30A3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.0930% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.7739% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.8745% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8166% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 89.6644% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.3129% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,28.8,0.5,0.2,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen,ENSG00000115194,SLC30A3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0470149,0.0225706,-0.291255
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 80.7739% (minimum 99%, Missing); cerebral cortex: 69.8745% (minimum 99%, Missing); choroid plexus: 98.8166% (minimum 99%, Missing); heart muscle: 89.6644% (minimum 95%, Enhanced); hippocampal formation: 85.3129% (minimum 99%, Missing)",0,1,partial,28.8,0.5,0.2,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 6)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen,ENSG00000115194,SLC30A3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.291255
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,22.2,10.7,16.7,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); thymus: 16.7 nTPM (manageable, limit 5); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 2); parathyroid gland: 10 nTPM (protected, limit 2); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 2); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 2); adipose tissue: 8.1 nTPM (manageable, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 2); urinary bladder: 7.5 nTPM (protected, limit 2); colon: 7.3 nTPM (protected, limit 2); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); stomach: 6.9 nTPM (protected, limit 2); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115239,ASB3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.8780% (minimum 99%, Baseline (adaptation disabled)); amygdala: 41.5385% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 40.9091% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.0427% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 59.7345% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 41.9255% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 48.0427% (minimum 99%, Baseline (adaptation disabled)); colon: 64.9038% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.8392% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.2120% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.4714% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 46.5517% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 44.4079% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.0860% (minimum 99%, Baseline (adaptation disabled)); liver: 57.6923% (minimum 99%, Baseline (adaptation disabled)); lung: 58.1897% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.7851% (minimum 97%, Baseline (adaptation disabled)); midbrain: 39.9408% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.2174% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.4468% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 48.9130% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.3803% (minimum 97%, Baseline (adaptation disabled)); retina: 37.8151% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.0860% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 67.1642% (minimum 99%, Baseline (adaptation disabled)); skin: 60.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.9266% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.3803% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 54.2169% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.1236% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.1765% (minimum 97%, Baseline (adaptation disabled)); thymus: 44.7020% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.6559% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.2174% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.2857% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,22.2,10.7,16.7,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); thymus: 16.7 nTPM (manageable, limit 5); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 2); parathyroid gland: 10 nTPM (protected, limit 2); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 2); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 2); adipose tissue: 8.1 nTPM (manageable, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 2); urinary bladder: 7.5 nTPM (protected, limit 2); colon: 7.3 nTPM (protected, limit 2); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); stomach: 6.9 nTPM (protected, limit 2); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115239,ASB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.50298,-0.412149,-0.611849
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 95%, Uncertain); adrenal gland: 54.8780% (minimum 99%, Missing); amygdala: 41.5385% (minimum 99%, Missing); basal ganglia: 40.9091% (minimum 99%, Missing); bone marrow: 48.0427% (minimum 99%, Missing); cerebellum: 59.7345% (minimum 99%, Missing); cerebral cortex: 41.9255% (minimum 99%, Missing); choroid plexus: 48.0427% (minimum 99%, Missing); colon: 64.9038% (minimum 97%, Missing); duodenum: 67.8392% (minimum 99%, Missing); esophagus: 62.2120% (minimum 97%, Missing); heart muscle: 59.4714% (minimum 99%, Missing); hippocampal formation: 46.5517% (minimum 99%, Missing); hypothalamus: 44.4079% (minimum 99%, Missing); kidney: 61.0860% (minimum 99%, Missing); liver: 57.6923% (minimum 99%, Missing); lung: 58.1897% (minimum 99%, Missing); lymph node: 55.7851% (minimum 97%, Missing); midbrain: 39.9408% (minimum 99%, Missing); pancreas: 65.2174% (minimum 99%, Missing); parathyroid gland: 57.4468% (minimum 97%, Missing); pituitary gland: 48.9130% (minimum 99%, Missing); rectum: 63.3803% (minimum 97%, Missing); retina: 37.8151% (minimum 99%, Missing); salivary gland: 61.0860% (minimum 97%, Missing); skeletal muscle: 67.1642% (minimum 99%, Missing); skin: 60.0000% (minimum 95%, Missing); small intestine: 61.9266% (minimum 99%, Missing); smooth muscle: 63.3803% (minimum 99%, Missing); spinal cord: 54.2169% (minimum 99%, Missing); spleen: 52.1236% (minimum 95%, Missing); stomach: 66.1765% (minimum 97%, Missing); thymus: 44.7020% (minimum 95%, Missing); thyroid gland: 54.6559% (minimum 95%, Missing); tongue: 65.2174% (minimum 97%, Missing); urinary bladder: 64.2857% (minimum 97%, Missing)",0,6,partial,22.2,10.7,16.7,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); thymus: 16.7 nTPM (manageable, limit 5); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 2); parathyroid gland: 10 nTPM (protected, limit 2); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 2); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 2); adipose tissue: 8.1 nTPM (manageable, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 2); urinary bladder: 7.5 nTPM (protected, limit 2); colon: 7.3 nTPM (protected, limit 2); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); stomach: 6.9 nTPM (protected, limit 2); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115239,ASB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.50298,-0.412149,-0.611849
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,40.2,11.4,41.6,"thyroid gland: 41.6 nTPM (manageable, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 2); adipose tissue: 10.1 nTPM (manageable, limit 5); urinary bladder: 9.4 nTPM (protected, limit 2); thymus: 7.8 nTPM (manageable, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 4); tongue: 4.3 nTPM (protected, limit 2); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115252,PDE1A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.2523% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.7906% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.2105% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.2632% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.0392% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.1408% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.2632% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0547% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.7027% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.7238% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.1618% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.1233% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.2542% (minimum 99%, Baseline (adaptation disabled)); kidney: 46.0403% (minimum 99%, Baseline (adaptation disabled)); liver: 91.2234% (minimum 99%, Baseline (adaptation disabled)); lung: 90.7407% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.0139% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.2542% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.0139% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.7514% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.9539% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.1117% (minimum 97%, Baseline (adaptation disabled)); retina: 96.6197% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.4904% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.7027% (minimum 99%, Baseline (adaptation disabled)); skin: 94.2308% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.9649% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.3846% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.8755% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.2065% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.3980% (minimum 97%, Baseline (adaptation disabled)); thymus: 81.4727% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 45.1910% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.8601% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.4897% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,40.2,11.4,41.6,"thyroid gland: 41.6 nTPM (manageable, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); urinary bladder: 9.4 nTPM (protected, limit 2); thymus: 7.8 nTPM (manageable, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); tongue: 4.3 nTPM (protected, limit 2); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115252,PDE1A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.49809,-0.219453,-0.529597
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.2523% (minimum 95%, Missing); adrenal gland: 89.7906% (minimum 99%, Missing); amygdala: 72.2105% (minimum 99%, Missing); basal ganglia: 90.2632% (minimum 99%, Missing); cerebellum: 48.0392% (minimum 99%, Missing); cerebral cortex: 61.1408% (minimum 99%, Missing); choroid plexus: 90.2632% (minimum 99%, Missing); colon: 75.0547% (minimum 97%, Missing); duodenum: 92.7027% (minimum 99%, Missing); esophagus: 87.7238% (minimum 95%, Approved); heart muscle: 71.1618% (minimum 99%, Missing); hippocampal formation: 67.1233% (minimum 99%, Missing); hypothalamus: 82.2542% (minimum 99%, Missing); kidney: 46.0403% (minimum 99%, Missing); liver: 91.2234% (minimum 99%, Missing); lung: 90.7407% (minimum 99%, Missing); lymph node: 95.0139% (minimum 97%, Missing); midbrain: 82.2542% (minimum 99%, Missing); pancreas: 95.0139% (minimum 99%, Missing); parathyroid gland: 94.7514% (minimum 97%, Missing); pituitary gland: 92.9539% (minimum 99%, Missing); rectum: 85.1117% (minimum 97%, Missing); retina: 96.6197% (minimum 99%, Missing); salivary gland: 94.4904% (minimum 95%, Approved); skeletal muscle: 92.7027% (minimum 99%, Missing); skin: 94.2308% (minimum 95%, Missing); small intestine: 85.9649% (minimum 99%, Missing); smooth muscle: 75.3846% (minimum 98%, Approved); spinal cord: 68.8755% (minimum 99%, Missing); spleen: 93.2065% (minimum 95%, Missing); stomach: 86.3980% (minimum 97%, Missing); thymus: 81.4727% (minimum 95%, Missing); thyroid gland: 45.1910% (minimum 95%, Missing); tongue: 88.8601% (minimum 97%, Missing); urinary bladder: 78.4897% (minimum 97%, Missing)",0,2,partial,40.2,11.4,41.6,"thyroid gland: 41.6 nTPM (manageable, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 2); adipose tissue: 10.1 nTPM (manageable, limit 5); urinary bladder: 9.4 nTPM (protected, limit 2); thymus: 7.8 nTPM (manageable, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 4); tongue: 4.3 nTPM (protected, limit 2); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000115252,PDE1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.49809,-0.219453,-0.529597
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.9,1.4,3.3,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000115257,PCSK4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8626% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.3910% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.5291% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.3129% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.8146% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.8626% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.2686% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.2462% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.8225% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.6824% (minimum 99%, Baseline (adaptation disabled)); liver: 94.2647% (minimum 99%, Baseline (adaptation disabled)); lung: 98.4639% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.5647% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.9581% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.2817% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.3129% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0122% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,6.9,1.4,3.3,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000115257,PCSK4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00103858,0.00862595,-0.0871831
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8626% (minimum 99%, Missing); amygdala: 96.3910% (minimum 99%, Missing); basal ganglia: 95.5291% (minimum 99%, Missing); cerebellum: 98.3129% (minimum 99%, Missing); cerebral cortex: 95.8146% (minimum 99%, Missing); choroid plexus: 97.8626% (minimum 99%, Missing); duodenum: 97.2686% (minimum 99%, Missing); hippocampal formation: 96.2462% (minimum 99%, Missing); hypothalamus: 94.8225% (minimum 99%, Missing); kidney: 94.6824% (minimum 99%, Missing); liver: 94.2647% (minimum 99%, Missing); lung: 98.4639% (minimum 99%, Missing); midbrain: 97.5647% (minimum 99%, Missing); pancreas: 95.9581% (minimum 99%, Missing); pituitary gland: 90.2817% (minimum 99%, Missing); small intestine: 98.3129% (minimum 99%, Missing); spinal cord: 98.0122% (minimum 99%, Missing)",0,80,unavailable,6.9,1.4,3.3,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000115257,PCSK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00103858,0.00862595,-0.0871831
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,40.9,31.8,39.6,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); skin: 39.6 nTPM (manageable, limit 5); thyroid gland: 38.1 nTPM (manageable, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 2); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 2); adrenal gland: 29.5 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); salivary gland: 29 nTPM (protected, limit 2); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 2); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (manageable, limit 5); lung: 25.1 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); spleen: 23.9 nTPM (manageable, limit 5); colon: 23.3 nTPM (protected, limit 2); small intestine: 23.3 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 2); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 2); retina: 18.1 nTPM (vital, limit 1); choroid plexus: 15.5 nTPM (vital, limit 1); smooth muscle: 14.2 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5); rectum: 11.9 nTPM (protected, limit 2); tongue: 8.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000115274,INO80B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.6325% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.2352% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.5744% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.0110% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.6562% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.1446% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.6402% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0403% (minimum 99%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.2538% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.6771% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.4992% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.5415% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.5415% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.6612% (minimum 99%, Baseline (adaptation disabled)); liver: 59.8203% (minimum 99%, Baseline (adaptation disabled)); lung: 64.9930% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.6923% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.5522% (minimum 99%, Baseline (adaptation disabled)); pancreas: 53.3792% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.1450% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 53.2571% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.6581% (minimum 97%, Baseline (adaptation disabled)); retina: 72.0247% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.6402% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.6402% (minimum 99%, Baseline (adaptation disabled)); skin: 54.0603% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.6447% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.2866% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.0993% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.4388% (minimum 97%, Baseline (adaptation disabled)); thymus: 78.8494% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.0177% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.1155% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.0110% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,40.9,31.8,39.6,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); skin: 39.6 nTPM (manageable, limit 5); thyroid gland: 38.1 nTPM (manageable, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 2); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 2); adrenal gland: 29.5 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); salivary gland: 29 nTPM (protected, limit 2); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 2); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (manageable, limit 5); lung: 25.1 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); spleen: 23.9 nTPM (manageable, limit 5); colon: 23.3 nTPM (protected, limit 2); small intestine: 23.3 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 2); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 2); retina: 18.1 nTPM (vital, limit 1); choroid plexus: 15.5 nTPM (vital, limit 1); smooth muscle: 14.2 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5); rectum: 11.9 nTPM (protected, limit 2); tongue: 8.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000115274,INO80B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.409397,-0.375612,-0.457429
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.6325% (minimum 95%, Missing); adrenal gland: 61.2352% (minimum 99%, Missing); amygdala: 63.5744% (minimum 99%, Missing); basal ganglia: 64.0110% (minimum 99%, Missing); bone marrow: 69.6562% (minimum 99%, Missing); cerebellum: 56.1446% (minimum 99%, Missing); cerebral cortex: 61.6402% (minimum 99%, Missing); choroid plexus: 75.0403% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 71.2538% (minimum 99%, Missing); esophagus: 60.6771% (minimum 97%, Missing); heart muscle: 70.4992% (minimum 99%, Missing); hippocampal formation: 65.5415% (minimum 99%, Missing); hypothalamus: 65.5415% (minimum 99%, Missing); kidney: 63.6612% (minimum 99%, Missing); liver: 59.8203% (minimum 99%, Missing); lung: 64.9930% (minimum 99%, Missing); lymph node: 71.6923% (minimum 97%, Missing); midbrain: 69.5522% (minimum 99%, Missing); pancreas: 53.3792% (minimum 99%, Missing); parathyroid gland: 71.1450% (minimum 97%, Missing); pituitary gland: 53.2571% (minimum 99%, Missing); rectum: 79.6581% (minimum 97%, Missing); retina: 72.0247% (minimum 99%, Missing); salivary gland: 61.6402% (minimum 97%, Missing); skeletal muscle: 61.6402% (minimum 99%, Missing); skin: 54.0603% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); smooth muscle: 76.6447% (minimum 99%, Missing); spinal cord: 70.2866% (minimum 99%, Missing); spleen: 66.0993% (minimum 95%, Missing); stomach: 59.4388% (minimum 97%, Missing); thymus: 78.8494% (minimum 95%, Missing); thyroid gland: 55.0177% (minimum 95%, Missing); tongue: 84.1155% (minimum 97%, Missing); urinary bladder: 64.0110% (minimum 97%, Missing)",0,80,unavailable,40.9,31.8,39.6,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); skin: 39.6 nTPM (manageable, limit 5); thyroid gland: 38.1 nTPM (manageable, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 2); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 2); adrenal gland: 29.5 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); salivary gland: 29 nTPM (protected, limit 2); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 2); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (manageable, limit 5); lung: 25.1 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); spleen: 23.9 nTPM (manageable, limit 5); colon: 23.3 nTPM (protected, limit 2); small intestine: 23.3 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 2); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 2); retina: 18.1 nTPM (vital, limit 1); choroid plexus: 15.5 nTPM (vital, limit 1); smooth muscle: 14.2 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5); rectum: 11.9 nTPM (protected, limit 2); tongue: 8.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000115274,INO80B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.409397,-0.375612,-0.457429
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,16.9,14,13.4,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); thyroid gland: 13.1 nTPM (manageable, limit 5); parathyroid gland: 12 nTPM (protected, limit 2); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); urinary bladder: 10.2 nTPM (protected, limit 2); salivary gland: 9.9 nTPM (protected, limit 2); thymus: 9.9 nTPM (manageable, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 2); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); tongue: 5.9 nTPM (protected, limit 2); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000115970,THADA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0773% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.6842% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.8525% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.1549% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.5562% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 43.5986% (minimum 99%, Baseline (adaptation disabled)); colon: 58.8785% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.9036% (minimum 99%, Baseline (adaptation disabled)); esophagus: 56.7568% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.1549% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.5909% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.5342% (minimum 99%, Baseline (adaptation disabled)); liver: 42.7119% (minimum 99%, Baseline (adaptation disabled)); lung: 57.0136% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.3684% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.7865% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.9412% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.2195% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 53.8462% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.1081% (minimum 97%, Baseline (adaptation disabled)); retina: 60.8696% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 56.5022% (minimum 99%, Baseline (adaptation disabled)); skin: 48.4615% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.7982% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.2857% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.3911% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 58.8785% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 49.0272% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.1081% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.2632% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,16.9,14,13.4,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); thyroid gland: 13.1 nTPM (manageable, limit 5); parathyroid gland: 12 nTPM (protected, limit 2); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); urinary bladder: 10.2 nTPM (protected, limit 2); salivary gland: 9.9 nTPM (protected, limit 2); thymus: 9.9 nTPM (manageable, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 2); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); tongue: 5.9 nTPM (protected, limit 2); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000115970,THADA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.465385,-0.496316,-0.562881
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0773% (minimum 95%, Uncertain); adrenal gland: 58.3333% (minimum 99%, Missing); amygdala: 73.6842% (minimum 99%, Missing); basal ganglia: 68.8525% (minimum 99%, Missing); bone marrow: 59.1549% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Uncertain); cerebral cortex: 74.5562% (minimum 99%, Missing); choroid plexus: 43.5986% (minimum 99%, Missing); colon: 58.8785% (minimum 97%, Missing); duodenum: 75.9036% (minimum 99%, Missing); esophagus: 56.7568% (minimum 97%, Missing); heart muscle: 59.1549% (minimum 99%, Uncertain); hippocampal formation: 72.0000% (minimum 99%, Missing); hypothalamus: 71.5909% (minimum 99%, Missing); kidney: 57.5342% (minimum 99%, Missing); liver: 42.7119% (minimum 99%, Missing); lung: 57.0136% (minimum 99%, Missing); lymph node: 47.3684% (minimum 97%, Missing); midbrain: 70.7865% (minimum 99%, Missing); pancreas: 52.9412% (minimum 99%, Uncertain); parathyroid gland: 51.2195% (minimum 97%, Uncertain); pituitary gland: 53.8462% (minimum 99%, Missing); rectum: 68.1081% (minimum 97%, Missing); retina: 60.8696% (minimum 99%, Missing); salivary gland: 56.0000% (minimum 97%, Missing); skeletal muscle: 56.5022% (minimum 99%, Uncertain); skin: 48.4615% (minimum 95%, Missing); small intestine: 57.7982% (minimum 99%, Missing); smooth muscle: 64.2857% (minimum 99%, Missing); spinal cord: 70.3911% (minimum 99%, Missing); spleen: 52.5000% (minimum 95%, Uncertain); stomach: 58.8785% (minimum 97%, Missing); thymus: 56.0000% (minimum 95%, Missing); thyroid gland: 49.0272% (minimum 95%, Uncertain); tongue: 68.1081% (minimum 97%, Missing); urinary bladder: 55.2632% (minimum 97%, Uncertain)",0,1,partial,16.9,14,13.4,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); thyroid gland: 13.1 nTPM (manageable, limit 5); parathyroid gland: 12 nTPM (protected, limit 2); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); urinary bladder: 10.2 nTPM (protected, limit 2); salivary gland: 9.9 nTPM (protected, limit 2); thymus: 9.9 nTPM (manageable, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 2); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); tongue: 5.9 nTPM (protected, limit 2); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000115970,THADA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.465385,-0.496316,-0.562881
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,6.1,1.5,0.6,"kidney: 6.1 nTPM (vital, limit 6); retina: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000116183,PAPPA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 90.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.8115% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.0357% (minimum 99%, Baseline (adaptation disabled)); retina: 93.8462% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,6.1,1.5,0.6,"kidney: 6.1 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000116183,PAPPA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,0.0391892,0.00340426,-0.09
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 90.0000% (minimum 95%, Enhanced); pituitary gland: 98.0357% (minimum 99%, Missing); retina: 93.8462% (minimum 99%, Missing)",0,3,partial,6.1,1.5,0.6,"kidney: 6.1 nTPM (vital, limit 6); retina: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000116183,PAPPA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,0.05,0.03,-0.0515385
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,52.1,45.3,26.5,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 12); liver: 28.8 nTPM (vital, limit 6); spleen: 26.5 nTPM (manageable, limit 5); skin: 18.7 nTPM (manageable, limit 5); esophagus: 17.3 nTPM (protected, limit 2); small intestine: 15.9 nTPM (vital, limit 1); thymus: 14.3 nTPM (manageable, limit 5); stomach: 13.5 nTPM (protected, limit 12); colon: 13.4 nTPM (protected, limit 2); urinary bladder: 12.3 nTPM (protected, limit 12); rectum: 12 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 6); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 6); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000116191,RALGPS2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.9239% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.4790% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.8229% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 87.3275% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.5652% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.8229% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.8903% (minimum 99%, Baseline (adaptation disabled)); colon: 83.8554% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.6750% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.0921% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.9271% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.3989% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.5326% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.8206% (minimum 99%, Baseline (adaptation disabled)); liver: 70.7317% (minimum 99%, Baseline (adaptation disabled)); lung: 96.2656% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.5744% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.8903% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.9239% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.8065% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.1326% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.2941% (minimum 97%, Baseline (adaptation disabled)); retina: 57.1898% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.9239% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.1664% (minimum 99%, Baseline (adaptation disabled)); skin: 78.8222% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.4035% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.3524% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0282% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.4246% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.7545% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.9559% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.5789% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.6764% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.9817% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,52.1,45.3,26.5,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 2); liver: 28.8 nTPM (vital, limit 1); spleen: 26.5 nTPM (manageable, limit 5); skin: 18.7 nTPM (manageable, limit 5); esophagus: 17.3 nTPM (protected, limit 2); small intestine: 15.9 nTPM (vital, limit 1); thymus: 14.3 nTPM (manageable, limit 5); stomach: 13.5 nTPM (protected, limit 2); colon: 13.4 nTPM (protected, limit 2); urinary bladder: 12.3 nTPM (protected, limit 2); rectum: 12 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.9 nTPM (protected, limit 2); thyroid gland: 6.4 nTPM (manageable, limit 5); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 2); salivary gland: 5.3 nTPM (protected, limit 2); adipose tissue: 5.3 nTPM (manageable, limit 5); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000116191,RALGPS2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.225754,-0.364256,-0.418102
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 88.8889% (minimum 95%, Enhanced); amygdala: 97.4790% (minimum 99%, Missing); basal ganglia: 94.8229% (minimum 99%, Missing); bone marrow: 87.3275% (minimum 99%, Missing); cerebellum: 94.5652% (minimum 99%, Missing); cerebral cortex: 94.8229% (minimum 99%, Missing); choroid plexus: 97.8903% (minimum 99%, Missing); colon: 83.8554% (minimum 97%, Missing); duodenum: 86.6750% (minimum 99%, Missing); esophagus: 80.0921% (minimum 97%, Missing); heart muscle: 93.9271% (minimum 99%, Missing); hippocampal formation: 96.3989% (minimum 99%, Missing); hypothalamus: 96.5326% (minimum 99%, Missing); kidney: 91.8206% (minimum 99%, Missing); liver: 70.7317% (minimum 95%, Enhanced); lung: 96.2656% (minimum 99%, Missing); lymph node: 60.5744% (minimum 80%, Enhanced); midbrain: 97.8903% (minimum 99%, Missing); pancreas: 92.9239% (minimum 95%, Enhanced); pituitary gland: 96.1326% (minimum 99%, Missing); rectum: 85.2941% (minimum 97%, Missing); retina: 57.1898% (minimum 99%, Missing); skeletal muscle: 98.1664% (minimum 99%, Missing); skin: 78.8222% (minimum 95%, Missing); small intestine: 81.4035% (minimum 99%, Missing); smooth muscle: 86.3524% (minimum 95%, Enhanced); spinal cord: 98.0282% (minimum 99%, Missing); spleen: 72.4246% (minimum 95%, Missing); thymus: 82.9559% (minimum 95%, Missing); tongue: 92.6764% (minimum 97%, Missing)",0,7,partial,52.1,45.3,26.5,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 12); liver: 28.8 nTPM (vital, limit 6); spleen: 26.5 nTPM (manageable, limit 5); skin: 18.7 nTPM (manageable, limit 5); esophagus: 17.3 nTPM (protected, limit 2); small intestine: 15.9 nTPM (vital, limit 1); thymus: 14.3 nTPM (manageable, limit 5); stomach: 13.5 nTPM (protected, limit 12); colon: 13.4 nTPM (protected, limit 2); urinary bladder: 12.3 nTPM (protected, limit 12); rectum: 12 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 6); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 6); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000116191,RALGPS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.225754,-0.194256,-0.418102
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000116721,PRAMEF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000116721,PRAMEF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000116721,PRAMEF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,False,,0,1,unreliable,0.1,0,0,,cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000116726,PRAMEF12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;unresolved_reproductive_selectivity;reviewed_unreliable_ihc,True,True,True,,0,1,unreliable,0.1,0,0,,cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000116726,PRAMEF12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;unresolved_reproductive_selectivity;reviewed_unreliable_ihc,True,True,True,,0,1,unreliable,0.1,0,0,,cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000116726,PRAMEF12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,28.2,11.1,8.4,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); hypothalamus: 8.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); kidney: 8.4 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); smooth muscle: 6.4 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 2); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); skeletal muscle: 4.4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000116793,PHTF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.8068% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.0885% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.5272% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.4583% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.9724% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.9458% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 51.1265% (minimum 99%, Baseline (adaptation disabled)); colon: 86.5103% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.6657% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.1875% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.5272% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.8652% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.4278% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.8364% (minimum 99%, Baseline (adaptation disabled)); liver: 78.8770% (minimum 99%, Baseline (adaptation disabled)); lung: 78.8770% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.2857% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.5694% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.7175% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 72.6601% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.6019% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.2573% (minimum 97%, Baseline (adaptation disabled)); retina: 68.2870% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.3234% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.0206% (minimum 99%, Baseline (adaptation disabled)); skin: 94.5513% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.3234% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.1727% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.5886% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.8364% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.9444% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.2141% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.7647% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.3313% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.8652% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,28.2,11.1,8.4,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); hypothalamus: 8.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); kidney: 8.4 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); smooth muscle: 6.4 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 2); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); skeletal muscle: 4.4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000116793,PHTF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.171636,-0.243399,-0.478735
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.8068% (minimum 95%, Missing); adrenal gland: 79.0885% (minimum 99%, Missing); amygdala: 84.5272% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 61.4583% (minimum 99%, Missing); cerebellum: 67.9724% (minimum 99%, Missing); cerebral cortex: 79.9458% (minimum 99%, Missing); choroid plexus: 51.1265% (minimum 99%, Missing); colon: 86.5103% (minimum 97%, Missing); duodenum: 89.6657% (minimum 99%, Missing); esophagus: 92.1875% (minimum 97%, Missing); heart muscle: 84.5272% (minimum 99%, Missing); hippocampal formation: 82.8652% (minimum 99%, Missing); hypothalamus: 77.4278% (minimum 99%, Missing); kidney: 77.8364% (minimum 99%, Missing); liver: 78.8770% (minimum 99%, Missing); lung: 78.8770% (minimum 99%, Missing); lymph node: 84.2857% (minimum 97%, Missing); midbrain: 83.5694% (minimum 99%, Missing); pancreas: 81.7175% (minimum 99%, Missing); parathyroid gland: 72.6601% (minimum 97%, Missing); pituitary gland: 71.6019% (minimum 99%, Missing); rectum: 86.2573% (minimum 97%, Missing); retina: 68.2870% (minimum 99%, Missing); salivary gland: 88.3234% (minimum 97%, Missing); skeletal muscle: 87.0206% (minimum 99%, Missing); skin: 94.5513% (minimum 95%, Missing); small intestine: 88.3234% (minimum 99%, Missing); smooth muscle: 82.1727% (minimum 99%, Missing); spinal cord: 88.5886% (minimum 99%, Missing); spleen: 77.8364% (minimum 95%, Missing); stomach: 81.9444% (minimum 97%, Missing); thymus: 90.2141% (minimum 95%, Missing); thyroid gland: 86.7647% (minimum 95%, Missing); tongue: 91.3313% (minimum 97%, Missing); urinary bladder: 82.8652% (minimum 97%, Missing)",0,80,unavailable,28.2,11.1,8.4,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); hypothalamus: 8.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); kidney: 8.4 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); smooth muscle: 6.4 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 2); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); skeletal muscle: 4.4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000116793,PHTF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.171636,-0.243399,-0.478735
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,53,33.9,41.6,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); spleen: 41.6 nTPM (manageable, limit 5); parathyroid gland: 33.9 nTPM (protected, limit 2); urinary bladder: 31.6 nTPM (protected, limit 2); skin: 31.5 nTPM (manageable, limit 5); adipose tissue: 27.6 nTPM (manageable, limit 5); lung: 26.2 nTPM (vital, limit 1); thymus: 25.7 nTPM (manageable, limit 5); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 2); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 2); smooth muscle: 21.1 nTPM (vital, limit 2); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 2); colon: 19.3 nTPM (protected, limit 2); rectum: 19.3 nTPM (protected, limit 2); stomach: 18.4 nTPM (protected, limit 2); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000116977,LGALS8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 66.7870% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.0866% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.2084% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.3991% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.4463% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.8401% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.5843% (minimum 99%, Baseline (adaptation disabled)); colon: 74.1979% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.5490% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.0263% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.1521% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.4978% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.6176% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.9719% (minimum 99%, Baseline (adaptation disabled)); liver: 53.6750% (minimum 99%, Baseline (adaptation disabled)); lung: 67.9315% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.3422% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.4586% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.4543% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.0805% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 81.8584% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.1979% (minimum 97%, Baseline (adaptation disabled)); retina: 71.4286% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.0779% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.5161% (minimum 99%, Baseline (adaptation disabled)); skin: 63.7931% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.3422% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.4543% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.6270% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.1576% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.1015% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.3498% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 76.8698% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.0465% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.7199% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,53,33.9,41.6,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); spleen: 41.6 nTPM (manageable, limit 5); parathyroid gland: 33.9 nTPM (protected, limit 2); urinary bladder: 31.6 nTPM (protected, limit 2); skin: 31.5 nTPM (manageable, limit 5); adipose tissue: 27.6 nTPM (manageable, limit 5); lung: 26.2 nTPM (vital, limit 1); thymus: 25.7 nTPM (manageable, limit 5); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 2); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 2); smooth muscle: 21.1 nTPM (vital, limit 1); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 2); colon: 19.3 nTPM (protected, limit 2); rectum: 19.3 nTPM (protected, limit 2); stomach: 18.4 nTPM (protected, limit 2); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000116977,LGALS8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.378424,-0.349195,-0.478479
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 66.7870% (minimum 95%, Missing); adrenal gland: 80.0866% (minimum 99%, Missing); amygdala: 83.2084% (minimum 99%, Missing); basal ganglia: 79.3991% (minimum 99%, Missing); bone marrow: 55.5000% (minimum 99%, Missing); cerebellum: 76.4463% (minimum 99%, Missing); cerebral cortex: 77.8401% (minimum 99%, Missing); choroid plexus: 83.5843% (minimum 99%, Missing); colon: 74.1979% (minimum 97%, Missing); duodenum: 72.5490% (minimum 99%, Missing); esophagus: 73.0263% (minimum 97%, Missing); heart muscle: 51.1521% (minimum 99%, Missing); hippocampal formation: 81.4978% (minimum 99%, Missing); hypothalamus: 81.6176% (minimum 99%, Missing); kidney: 70.9719% (minimum 99%, Missing); liver: 53.6750% (minimum 99%, Missing); lung: 67.9315% (minimum 99%, Missing); lymph node: 70.3422% (minimum 97%, Missing); midbrain: 83.4586% (minimum 99%, Missing); pancreas: 72.4543% (minimum 99%, Missing); parathyroid gland: 62.0805% (minimum 97%, Missing); pituitary gland: 81.8584% (minimum 99%, Missing); rectum: 74.1979% (minimum 97%, Missing); retina: 71.4286% (minimum 99%, Missing); salivary gland: 72.0779% (minimum 97%, Missing); skeletal muscle: 89.5161% (minimum 99%, Missing); skin: 63.7931% (minimum 95%, Missing); small intestine: 70.3422% (minimum 99%, Missing); smooth muscle: 72.4543% (minimum 98%, Approved); spinal cord: 79.6270% (minimum 99%, Missing); spleen: 57.1576% (minimum 95%, Missing); stomach: 75.1015% (minimum 97%, Missing); thymus: 68.3498% (minimum 95%, Missing); thyroid gland: 76.8698% (minimum 95%, Missing); tongue: 86.0465% (minimum 97%, Missing); urinary bladder: 63.7199% (minimum 97%, Missing)",0,4,partial,53,33.9,41.6,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); spleen: 41.6 nTPM (manageable, limit 5); parathyroid gland: 33.9 nTPM (protected, limit 2); urinary bladder: 31.6 nTPM (protected, limit 2); skin: 31.5 nTPM (manageable, limit 5); adipose tissue: 27.6 nTPM (manageable, limit 5); lung: 26.2 nTPM (vital, limit 1); thymus: 25.7 nTPM (manageable, limit 5); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 2); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 2); smooth muscle: 21.1 nTPM (vital, limit 2); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 2); colon: 19.3 nTPM (protected, limit 2); rectum: 19.3 nTPM (protected, limit 2); stomach: 18.4 nTPM (protected, limit 2); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000116977,LGALS8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.378424,-0.349195,-0.478479
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,ENSG00000117148,ACTL8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.5714% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,ENSG00000117148,ACTL8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.00183099,-0.00428571
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.5714% (minimum 99%, Missing)",0,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,ENSG00000117148,ACTL8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.00183099,-0.00428571
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,10,partial,115.1,8.9,11.7,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 2); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); colon: 7.9 nTPM (protected, limit 2); rectum: 7.6 nTPM (protected, limit 2); stomach: 6.9 nTPM (protected, limit 2); pancreas: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); choroid plexus: 6.6 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 2); esophagus: 6.2 nTPM (protected, limit 2); urinary bladder: 5.5 nTPM (protected, limit 2); hypothalamus: 5.4 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 3); midbrain: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skin 1 / arrector pili muscle cells: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / arrector pili muscle cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117155,SSX2IP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.1591% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.5993% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.5427% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 87.4680% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.4146% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.1056% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.9560% (minimum 99%, Baseline (adaptation disabled)); colon: 92.8507% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.9544% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.3015% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.8532% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.7965% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.5823% (minimum 99%, Baseline (adaptation disabled)); liver: 87.9177% (minimum 99%, Baseline (adaptation disabled)); lung: 96.5193% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.3015% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.8839% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.6986% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.0179% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.6890% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.1034% (minimum 97%, Baseline (adaptation disabled)); retina: 47.1291% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.8701% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.7925% (minimum 99%, Baseline (adaptation disabled)); skin: 94.2149% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.7203% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.8769% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.8839% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.6986% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.7638% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.7667% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.9121% (minimum 97%, Baseline (adaptation disabled))",0,10,partial,115.1,8.9,11.7,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 2); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); colon: 7.9 nTPM (protected, limit 2); rectum: 7.6 nTPM (protected, limit 2); stomach: 6.9 nTPM (protected, limit 2); pancreas: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); choroid plexus: 6.6 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 2); esophagus: 6.2 nTPM (protected, limit 2); urinary bladder: 5.5 nTPM (protected, limit 2); hypothalamus: 5.4 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skin 1 / arrector pili muscle cells: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / arrector pili muscle cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117155,SSX2IP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0523622,-0.0498206,-0.518709
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.1591% (minimum 99%, Missing); amygdala: 92.5993% (minimum 99%, Missing); basal ganglia: 87.5427% (minimum 99%, Missing); bone marrow: 87.4680% (minimum 99%, Missing); cerebellum: 83.4146% (minimum 99%, Missing); cerebral cortex: 79.1056% (minimum 99%, Missing); choroid plexus: 93.9560% (minimum 99%, Missing); colon: 92.8507% (minimum 97%, Missing); duodenum: 70.9544% (minimum 99%, Missing); esophagus: 94.3015% (minimum 97%, Missing); heart muscle: 91.8532% (minimum 99%, Missing); hippocampal formation: 90.7965% (minimum 99%, Missing); hypothalamus: 95.0000% (minimum 99%, Missing); kidney: 86.5823% (minimum 99%, Missing); liver: 87.9177% (minimum 99%, Missing); lung: 96.5193% (minimum 99%, Missing); lymph node: 94.3015% (minimum 97%, Missing); midbrain: 96.8839% (minimum 99%, Missing); pancreas: 93.6986% (minimum 99%, Missing); parathyroid gland: 92.0179% (minimum 97%, Missing); pituitary gland: 91.6890% (minimum 99%, Missing); rectum: 93.1034% (minimum 97%, Missing); retina: 47.1291% (minimum 99%, Missing); salivary gland: 93.8701% (minimum 97%, Missing); skeletal muscle: 96.7925% (minimum 97%, Supported); skin: 94.2149% (minimum 95%, Missing); small intestine: 79.7203% (minimum 99%, Missing); smooth muscle: 90.8769% (minimum 99%, Missing); spinal cord: 96.8839% (minimum 99%, Missing); stomach: 93.6986% (minimum 97%, Missing); thymus: 89.7638% (minimum 95%, Missing); thyroid gland: 92.7667% (minimum 95%, Missing); urinary bladder: 94.9121% (minimum 97%, Missing)",0,10,partial,115.1,8.9,11.7,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 2); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); colon: 7.9 nTPM (protected, limit 2); rectum: 7.6 nTPM (protected, limit 2); stomach: 6.9 nTPM (protected, limit 2); pancreas: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); choroid plexus: 6.6 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 2); esophagus: 6.2 nTPM (protected, limit 2); urinary bladder: 5.5 nTPM (protected, limit 2); hypothalamus: 5.4 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 3); midbrain: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skin 1 / arrector pili muscle cells: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / arrector pili muscle cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117155,SSX2IP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0523622,-0.0498206,-0.518709
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,0.5,0.9,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000117400,MPL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.2381% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.2381% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.0541% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 71.4286% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); colon: 86.9565% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.9565% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.2381% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 76.9231% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.9091% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.2381% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.0741% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.9565% (minimum 97%, Baseline (adaptation disabled)); rectum: 86.9565% (minimum 97%, Baseline (adaptation disabled)); retina: 57.1429% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.9231% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.9091% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 74.0741% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.2381% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.0000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 68.9655% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.9565% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.9091% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.7,0.5,0.9,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000117400,MPL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.260345,-0.17,-0.449459
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 95.2381% (minimum 99%, Missing); basal ganglia: 95.2381% (minimum 99%, Missing); bone marrow: 54.0541% (minimum 99%, Missing); cerebral cortex: 71.4286% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); colon: 86.9565% (minimum 97%, Missing); duodenum: 86.9565% (minimum 99%, Missing); esophagus: 80.0000% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 95.2381% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 76.9231% (minimum 99%, Missing); lymph node: 90.9091% (minimum 97%, Missing); midbrain: 95.2381% (minimum 99%, Missing); pancreas: 74.0741% (minimum 99%, Missing); parathyroid gland: 86.9565% (minimum 97%, Missing); rectum: 86.9565% (minimum 97%, Missing); retina: 57.1429% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 76.9231% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 90.9091% (minimum 99%, Missing); smooth muscle: 74.0741% (minimum 99%, Missing); spinal cord: 95.2381% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thyroid gland: 68.9655% (minimum 95%, Missing); tongue: 86.9565% (minimum 97%, Missing); urinary bladder: 90.9091% (minimum 97%, Missing)",0,80,unavailable,1.7,0.5,0.9,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000117400,MPL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.260345,-0.17,-0.449459
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,45.2,17.7,30.2,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 2); adipose tissue: 30.2 nTPM (manageable, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 2); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 2); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 2); skeletal muscle: 11.6 nTPM (vital, limit 2); midbrain: 11.6 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 2); spleen: 10.9 nTPM (manageable, limit 5); amygdala: 10.5 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 2); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 2); esophagus: 6.9 nTPM (protected, limit 4); lymph node: 6.1 nTPM (protected, limit 2); skin: 6.1 nTPM (manageable, limit 5); rectum: 4.7 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117461,PIK3R3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2949% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.6658% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.0745% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.8420% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.4820% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 37.4827% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.2073% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.2592% (minimum 99%, Baseline (adaptation disabled)); colon: 79.0087% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.7351% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.7059% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 44.2088% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.1236% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.6658% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.3178% (minimum 99%, Baseline (adaptation disabled)); liver: 87.4194% (minimum 99%, Baseline (adaptation disabled)); lung: 60.0887% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.6265% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.0258% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.7595% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.8454% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.5537% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.2201% (minimum 97%, Baseline (adaptation disabled)); retina: 61.0360% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.9567% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 70.0258% (minimum 99%, Baseline (adaptation disabled)); skin: 81.6265% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.5537% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.9424% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.4875% (minimum 99%, Baseline (adaptation disabled)); spleen: 71.3158% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.8420% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.0745% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.2592% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.4911% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.4589% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,45.2,17.7,30.2,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 1); adipose tissue: 30.2 nTPM (manageable, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 2); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 2); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 2); skeletal muscle: 11.6 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); amygdala: 10.5 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 2); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 2); esophagus: 6.9 nTPM (protected, limit 2); lymph node: 6.1 nTPM (protected, limit 2); skin: 6.1 nTPM (manageable, limit 5); rectum: 4.7 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117461,PIK3R3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.477051,-0.365089,-0.615173
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2949% (minimum 95%, Missing); adrenal gland: 69.6658% (minimum 99%, Missing); amygdala: 72.0745% (minimum 99%, Missing); basal ganglia: 73.8420% (minimum 99%, Missing); bone marrow: 97.4820% (minimum 99%, Missing); cerebellum: 37.4827% (minimum 99%, Missing); cerebral cortex: 70.2073% (minimum 99%, Missing); choroid plexus: 66.2592% (minimum 99%, Missing); colon: 79.0087% (minimum 97%, Missing); duodenum: 89.7351% (minimum 99%, Missing); esophagus: 79.7059% (minimum 95%, Approved); heart muscle: 44.2088% (minimum 98%, Approved); hippocampal formation: 76.1236% (minimum 99%, Missing); hypothalamus: 69.6658% (minimum 99%, Missing); kidney: 63.3178% (minimum 99%, Missing); liver: 87.4194% (minimum 99%, Missing); lung: 60.0887% (minimum 99%, Missing); lymph node: 81.6265% (minimum 97%, Missing); midbrain: 70.0258% (minimum 99%, Missing); pancreas: 85.7595% (minimum 99%, Missing); parathyroid gland: 69.8454% (minimum 97%, Missing); pituitary gland: 76.5537% (minimum 99%, Missing); rectum: 85.2201% (minimum 97%, Missing); retina: 61.0360% (minimum 99%, Missing); salivary gland: 68.9567% (minimum 97%, Missing); skeletal muscle: 70.0258% (minimum 98%, Approved); skin: 81.6265% (minimum 95%, Missing); small intestine: 76.5537% (minimum 99%, Missing); smooth muscle: 70.9424% (minimum 98%, Approved); spinal cord: 75.4875% (minimum 99%, Missing); spleen: 71.3158% (minimum 95%, Missing); stomach: 73.8420% (minimum 97%, Missing); thymus: 72.0745% (minimum 95%, Missing); thyroid gland: 66.2592% (minimum 95%, Missing); tongue: 60.4911% (minimum 97%, Missing); urinary bladder: 65.4589% (minimum 97%, Missing)",0,4,partial,45.2,17.7,30.2,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 2); adipose tissue: 30.2 nTPM (manageable, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 2); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 2); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 2); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 2); skeletal muscle: 11.6 nTPM (vital, limit 2); midbrain: 11.6 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 2); spleen: 10.9 nTPM (manageable, limit 5); amygdala: 10.5 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 2); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 2); esophagus: 6.9 nTPM (protected, limit 4); lymph node: 6.1 nTPM (protected, limit 2); skin: 6.1 nTPM (manageable, limit 5); rectum: 4.7 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117461,PIK3R3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.477051,-0.365089,-0.615173
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,25.1,31.3,18.1,"esophagus: 31.3 nTPM (protected, limit 2); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); skin: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 2); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 2); parathyroid gland: 14.6 nTPM (protected, limit 2); liver: 14.5 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); colon: 13.4 nTPM (protected, limit 2); stomach: 12.7 nTPM (protected, limit 2); adrenal gland: 12.7 nTPM (vital, limit 1); lung: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 2); small intestine: 12.3 nTPM (vital, limit 1); spleen: 12.1 nTPM (manageable, limit 5); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 2); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 2); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117475,BLZF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.2479% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.8051% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.7308% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.1296% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 57.5296% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.9506% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.4487% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.9524% (minimum 99%, Baseline (adaptation disabled)); colon: 71.7300% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.9130% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.0674% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.8259% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.9277% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.3245% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.4603% (minimum 99%, Baseline (adaptation disabled)); liver: 70.1031% (minimum 99%, Baseline (adaptation disabled)); lung: 73.1183% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.7253% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.9524% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.7037% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.9588% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.3878% (minimum 97%, Baseline (adaptation disabled)); retina: 60.6061% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.4341% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 75.8929% (minimum 99%, Baseline (adaptation disabled)); skin: 66.1479% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.4341% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.4062% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.1609% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.7527% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.8051% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.7300% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.2591% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.2332% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.0000% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,25.1,31.3,18.1,"esophagus: 31.3 nTPM (protected, limit 2); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); skin: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 2); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 2); parathyroid gland: 14.6 nTPM (protected, limit 2); liver: 14.5 nTPM (vital, limit 1); adipose tissue: 14.4 nTPM (manageable, limit 5); colon: 13.4 nTPM (protected, limit 2); thymus: 13.4 nTPM (manageable, limit 5); adrenal gland: 12.7 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); lung: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 2); small intestine: 12.3 nTPM (vital, limit 1); spleen: 12.1 nTPM (manageable, limit 5); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 2); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 2); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117475,BLZF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.297409,-0.449326,-0.414704
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.2479% (minimum 80%, Supported); adrenal gland: 72.8051% (minimum 99%, Missing); amygdala: 81.7308% (minimum 99%, Missing); basal ganglia: 83.1296% (minimum 99%, Missing); bone marrow: 57.5296% (minimum 99%, Missing); cerebellum: 83.9506% (minimum 99%, Missing); cerebral cortex: 77.4487% (minimum 99%, Missing); choroid plexus: 80.9524% (minimum 99%, Missing); colon: 71.7300% (minimum 97%, Missing); duodenum: 73.9130% (minimum 99%, Missing); esophagus: 52.0674% (minimum 97%, Missing); heart muscle: 68.8259% (minimum 99%, Missing); hippocampal formation: 81.9277% (minimum 99%, Missing); hypothalamus: 82.3245% (minimum 99%, Missing); kidney: 67.4603% (minimum 99%, Missing); liver: 70.1031% (minimum 99%, Missing); lung: 73.1183% (minimum 99%, Missing); lymph node: 74.7253% (minimum 97%, Missing); midbrain: 80.9524% (minimum 99%, Missing); pancreas: 78.7037% (minimum 99%, Missing); parathyroid gland: 69.9588% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 69.3878% (minimum 97%, Missing); retina: 60.6061% (minimum 99%, Missing); salivary gland: 73.4341% (minimum 97%, Missing); skeletal muscle: 75.8929% (minimum 99%, Missing); skin: 66.1479% (minimum 95%, Missing); small intestine: 73.4341% (minimum 99%, Missing); smooth muscle: 66.4062% (minimum 99%, Missing); spinal cord: 78.1609% (minimum 99%, Missing); spleen: 73.7527% (minimum 95%, Missing); stomach: 72.8051% (minimum 97%, Missing); thymus: 71.7300% (minimum 95%, Missing); thyroid gland: 65.2591% (minimum 95%, Missing); tongue: 76.2332% (minimum 97%, Missing); urinary bladder: 68.0000% (minimum 97%, Missing)",0,5,partial,25.1,31.3,18.1,"esophagus: 31.3 nTPM (protected, limit 2); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); skin: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 2); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 2); parathyroid gland: 14.6 nTPM (protected, limit 2); liver: 14.5 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); colon: 13.4 nTPM (protected, limit 2); stomach: 12.7 nTPM (protected, limit 2); adrenal gland: 12.7 nTPM (vital, limit 1); lung: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 2); small intestine: 12.3 nTPM (vital, limit 1); spleen: 12.1 nTPM (manageable, limit 5); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 2); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 2); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117475,BLZF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.297409,-0.449326,-0.414704
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,38.7,11.2,0.5,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 6); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000117477,CCDC181,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.7266% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.1925% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.1194% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0769% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.2102% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.8929% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 44.7368% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 93.4066% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.5076% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.6721% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.9936% (minimum 99%, Baseline (adaptation disabled)); lung: 93.7500% (minimum 99%, Baseline (adaptation disabled)); midbrain: 80.9524% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.6289% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.4823% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.1647% (minimum 99%, Baseline (adaptation disabled)); retina: 39.7196% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.4556% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.4066% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.4371% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.4444% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.8647% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,38.7,11.2,0.5,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); parathyroid gland: 11.2 nTPM (protected, limit 2); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000117477,CCDC181,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0307692,-0.275177,-0.592804
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.7266% (minimum 95%, Enhanced); amygdala: 79.1925% (minimum 99%, Missing); basal ganglia: 76.1194% (minimum 99%, Missing); cerebellum: 81.2102% (minimum 95%, Enhanced); cerebral cortex: 75.8929% (minimum 95%, Enhanced); choroid plexus: 44.7368% (minimum 99%, Missing); heart muscle: 93.4066% (minimum 95%, Enhanced); hippocampal formation: 77.5076% (minimum 99%, Missing); hypothalamus: 69.6721% (minimum 99%, Missing); kidney: 81.9936% (minimum 95%, Enhanced); lung: 93.7500% (minimum 95%, Enhanced); midbrain: 80.9524% (minimum 99%, Missing); pancreas: 87.6289% (minimum 95%, Enhanced); parathyroid gland: 69.4823% (minimum 80%, Enhanced); pituitary gland: 59.1647% (minimum 99%, Missing); retina: 39.7196% (minimum 99%, Missing); smooth muscle: 93.4066% (minimum 95%, Enhanced); spinal cord: 84.4371% (minimum 99%, Missing)",0,6,partial,38.7,11.2,0.5,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 6); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000117477,CCDC181,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0383721,-0.105177,-0.592804
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,20.3,32.3,14.3,"colon: 32.3 nTPM (protected, limit 2); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 2); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 2); thyroid gland: 11.6 nTPM (manageable, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); spleen: 11.2 nTPM (manageable, limit 5); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); tongue: 8.6 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); salivary gland: 8 nTPM (protected, limit 2); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 2); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); lymph node: 5.8 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000117569,PTBP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6622% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.9186% (minimum 99%, Baseline (adaptation disabled)); amygdala: 57.6441% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.5263% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.8605% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.7619% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 59.1260% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); colon: 41.5913% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.8209% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.9186% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.1634% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.8926% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.2885% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.8623% (minimum 99%, Baseline (adaptation disabled)); liver: 75.9076% (minimum 99%, Baseline (adaptation disabled)); lung: 73.2484% (minimum 99%, Baseline (adaptation disabled)); lymph node: 79.8611% (minimum 97%, Baseline (adaptation disabled)); midbrain: 55.2885% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.9231% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.4487% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.4983% (minimum 97%, Baseline (adaptation disabled)); retina: 63.7119% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.1935% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 67.8466% (minimum 99%, Baseline (adaptation disabled)); skin: 73.4824% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.7887% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.6067% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.1178% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.2515% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.0920% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.2771% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.4740% (minimum 95%, Baseline (adaptation disabled)); tongue: 72.7848% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.6441% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,20.3,32.3,14.3,"colon: 32.3 nTPM (protected, limit 2); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 2); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 2); thyroid gland: 11.6 nTPM (manageable, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); spleen: 11.2 nTPM (manageable, limit 5); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); tongue: 8.6 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); salivary gland: 8 nTPM (protected, limit 2); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 2); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); lymph node: 5.8 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000117569,PTBP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.333378,-0.554087,-0.458822
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6622% (minimum 95%, Uncertain); adrenal gland: 74.9186% (minimum 99%, Uncertain); amygdala: 57.6441% (minimum 99%, Missing); basal ganglia: 60.5263% (minimum 99%, Missing); bone marrow: 66.8605% (minimum 99%, Uncertain); cerebellum: 54.7619% (minimum 99%, Uncertain); cerebral cortex: 59.1260% (minimum 99%, Uncertain); choroid plexus: 90.9091% (minimum 99%, Missing); colon: 41.5913% (minimum 97%, Uncertain); duodenum: 85.8209% (minimum 99%, Uncertain); esophagus: 74.9186% (minimum 97%, Missing); heart muscle: 75.1634% (minimum 99%, Uncertain); hippocampal formation: 54.8926% (minimum 99%, Missing); hypothalamus: 55.2885% (minimum 99%, Missing); kidney: 68.8623% (minimum 99%, Uncertain); liver: 75.9076% (minimum 99%, Uncertain); lung: 73.2484% (minimum 99%, Uncertain); lymph node: 79.8611% (minimum 97%, Uncertain); midbrain: 55.2885% (minimum 99%, Missing); pancreas: 76.9231% (minimum 99%, Missing); parathyroid gland: 90.9091% (minimum 97%, Uncertain); pituitary gland: 67.4487% (minimum 99%, Missing); rectum: 78.4983% (minimum 97%, Uncertain); retina: 63.7119% (minimum 99%, Missing); salivary gland: 74.1935% (minimum 97%, Uncertain); skeletal muscle: 67.8466% (minimum 99%, Uncertain); skin: 73.4824% (minimum 95%, Uncertain); small intestine: 64.7887% (minimum 99%, Uncertain); smooth muscle: 64.6067% (minimum 99%, Uncertain); spinal cord: 53.1178% (minimum 99%, Missing); spleen: 67.2515% (minimum 95%, Uncertain); stomach: 66.0920% (minimum 97%, Uncertain); thymus: 69.2771% (minimum 95%, Missing); thyroid gland: 66.4740% (minimum 95%, Uncertain); tongue: 72.7848% (minimum 97%, Missing); urinary bladder: 57.6441% (minimum 97%, Uncertain)",0,1,partial,20.3,32.3,14.3,"colon: 32.3 nTPM (protected, limit 2); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 2); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 2); thyroid gland: 11.6 nTPM (manageable, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); spleen: 11.2 nTPM (manageable, limit 5); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); tongue: 8.6 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); salivary gland: 8 nTPM (protected, limit 2); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 2); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); lymph node: 5.8 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000117569,PTBP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.333378,-0.554087,-0.458822
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,1.9,2.2,3.6,"lymph node: 2.2 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117586,TNFSF4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.5510% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.6087% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.8511% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.3721% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.8511% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.3721% (minimum 99%, Baseline (adaptation disabled)); colon: 79.1667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.6829% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.3636% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.1667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.8511% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.8511% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.6087% (minimum 99%, Baseline (adaptation disabled)); liver: 80.8511% (minimum 99%, Baseline (adaptation disabled)); lung: 76.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.8511% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.5510% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.3721% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.6981% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 74.5098% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.4762% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 92.6829% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.6087% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.6087% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.8511% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.3704% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.4444% (minimum 97%, Baseline (adaptation disabled)); thymus: 51.3514% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.4762% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.0769% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,1.9,2.2,3.6,"lymph node: 2.2 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117586,TNFSF4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.436486,-0.336667,-0.323333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.5510% (minimum 90%, Approved); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 82.6087% (minimum 99%, Missing); basal ganglia: 80.8511% (minimum 99%, Missing); bone marrow: 88.3721% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 80.8511% (minimum 99%, Missing); choroid plexus: 88.3721% (minimum 99%, Missing); colon: 79.1667% (minimum 97%, Missing); duodenum: 92.6829% (minimum 99%, Missing); esophagus: 86.3636% (minimum 97%, Missing); heart muscle: 79.1667% (minimum 99%, Missing); hippocampal formation: 80.8511% (minimum 99%, Missing); hypothalamus: 80.8511% (minimum 99%, Missing); kidney: 82.6087% (minimum 99%, Missing); liver: 80.8511% (minimum 99%, Missing); lung: 76.0000% (minimum 99%, Missing); lymph node: 63.3333% (minimum 97%, Missing); midbrain: 80.8511% (minimum 99%, Missing); pancreas: 77.5510% (minimum 99%, Missing); parathyroid gland: 88.3721% (minimum 95%, Approved); pituitary gland: 71.6981% (minimum 99%, Missing); rectum: 76.0000% (minimum 97%, Missing); retina: 74.5098% (minimum 99%, Missing); salivary gland: 90.4762% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); skin: 92.6829% (minimum 95%, Missing); small intestine: 82.6087% (minimum 99%, Missing); smooth muscle: 82.6087% (minimum 99%, Missing); spinal cord: 80.8511% (minimum 99%, Missing); spleen: 70.3704% (minimum 90%, Approved); stomach: 84.4444% (minimum 97%, Missing); thymus: 51.3514% (minimum 95%, Missing); thyroid gland: 90.4762% (minimum 95%, Missing); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 73.0769% (minimum 97%, Missing)",0,5,partial,1.9,2.2,3.6,"lymph node: 2.2 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117586,TNFSF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.436486,-0.336667,-0.323333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,17.5,8.8,18.7,"thymus: 18.7 nTPM (manageable, limit 5); bone marrow: 17.5 nTPM (vital, limit 6); lymph node: 8.8 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 6); small intestine: 6.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000117650,NEK2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 78.8392% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7879% (minimum 99%, Baseline (adaptation disabled)); colon: 92.0904% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.0552% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.8129% (minimum 97%, Baseline (adaptation disabled)); lung: 98.9378% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.1081% (minimum 97%, Baseline (adaptation disabled)); rectum: 89.8072% (minimum 97%, Baseline (adaptation disabled)); retina: 97.8979% (minimum 99%, Baseline (adaptation disabled)); skin: 93.9481% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.6815% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.1684% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.1652% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.7116% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,17.5,8.8,18.7,"thymus: 18.7 nTPM (manageable, limit 5); bone marrow: 17.5 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000117650,NEK2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.172884,-0.0889189,-0.201608
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 78.8392% (minimum 95%, Enhanced); duodenum: 90.0552% (minimum 95%, Enhanced); lymph node: 88.1081% (minimum 97%, Missing); rectum: 89.8072% (minimum 97%, Missing); retina: 97.8979% (minimum 99%, Missing); small intestine: 90.6815% (minimum 99%, Missing); thymus: 77.7116% (minimum 95%, Missing)",0,2,partial,17.5,8.8,18.7,"thymus: 18.7 nTPM (manageable, limit 5); bone marrow: 17.5 nTPM (vital, limit 6); lymph node: 8.8 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 6); small intestine: 6.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000117650,NEK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.172884,-0.0889189,-0.161608
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,43.3,40.2,49.2,"adipose tissue: 49.2 nTPM (manageable, limit 10); skeletal muscle: 43.3 nTPM (vital, limit 2); tongue: 40.2 nTPM (protected, limit 2); esophagus: 39.3 nTPM (protected, limit 4); thyroid gland: 37.3 nTPM (manageable, limit 5); colon: 37.1 nTPM (protected, limit 2); smooth muscle: 34.9 nTPM (vital, limit 2); thymus: 34.8 nTPM (manageable, limit 5); urinary bladder: 33.7 nTPM (protected, limit 2); heart muscle: 33.6 nTPM (vital, limit 2); adrenal gland: 33.4 nTPM (vital, limit 1); salivary gland: 31.2 nTPM (protected, limit 2); lung: 31.1 nTPM (vital, limit 1); skin: 30 nTPM (manageable, limit 5); parathyroid gland: 29.7 nTPM (protected, limit 2); bone marrow: 29.3 nTPM (vital, limit 2); rectum: 26.9 nTPM (protected, limit 2); lymph node: 25.7 nTPM (protected, limit 2); kidney: 25.1 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 2); duodenum: 20.6 nTPM (vital, limit 1); spleen: 20.2 nTPM (manageable, limit 10); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117868,ESYT2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6430% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.2500% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.6494% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.4992% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.3966% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.3410% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.9285% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.0859% (minimum 99%, Baseline (adaptation disabled)); colon: 55.6750% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.3452% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.2491% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.1047% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.4728% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.4724% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.9930% (minimum 99%, Baseline (adaptation disabled)); liver: 67.6343% (minimum 99%, Baseline (adaptation disabled)); lung: 59.9743% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.4537% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.8510% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.9930% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.0747% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.9700% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.4014% (minimum 97%, Baseline (adaptation disabled)); retina: 77.5374% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.8972% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 51.8354% (minimum 99%, Baseline (adaptation disabled)); skin: 60.8355% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.4494% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.1779% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.6795% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.7605% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.8311% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.2482% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.5423% (minimum 95%, Baseline (adaptation disabled)); tongue: 53.6866% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.0324% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,43.3,40.2,49.2,"adipose tissue: 49.2 nTPM (manageable, limit 5); skeletal muscle: 43.3 nTPM (vital, limit 1); tongue: 40.2 nTPM (protected, limit 2); esophagus: 39.3 nTPM (protected, limit 2); thyroid gland: 37.3 nTPM (manageable, limit 5); colon: 37.1 nTPM (protected, limit 2); smooth muscle: 34.9 nTPM (vital, limit 1); thymus: 34.8 nTPM (manageable, limit 5); urinary bladder: 33.7 nTPM (protected, limit 2); heart muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 33.4 nTPM (vital, limit 1); salivary gland: 31.2 nTPM (protected, limit 2); lung: 31.1 nTPM (vital, limit 1); skin: 30 nTPM (manageable, limit 5); parathyroid gland: 29.7 nTPM (protected, limit 2); bone marrow: 29.3 nTPM (vital, limit 1); rectum: 26.9 nTPM (protected, limit 2); lymph node: 25.7 nTPM (protected, limit 2); kidney: 25.1 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 2); duodenum: 20.6 nTPM (vital, limit 1); spleen: 20.2 nTPM (manageable, limit 5); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117868,ESYT2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.46357,-0.433134,-0.471646
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6430% (minimum 90%, Approved); adrenal gland: 58.2500% (minimum 99%, Missing); amygdala: 75.6494% (minimum 99%, Missing); basal ganglia: 70.4992% (minimum 99%, Missing); bone marrow: 61.3966% (minimum 98%, Approved); cerebellum: 67.3410% (minimum 99%, Missing); cerebral cortex: 70.9285% (minimum 99%, Missing); choroid plexus: 74.0859% (minimum 99%, Missing); colon: 55.6750% (minimum 97%, Missing); duodenum: 69.3452% (minimum 99%, Missing); esophagus: 54.2491% (minimum 95%, Approved); heart muscle: 58.1047% (minimum 98%, Approved); hippocampal formation: 72.4728% (minimum 99%, Missing); hypothalamus: 71.4724% (minimum 99%, Missing); kidney: 64.9930% (minimum 99%, Missing); liver: 67.6343% (minimum 99%, Missing); lung: 59.9743% (minimum 99%, Missing); lymph node: 64.4537% (minimum 97%, Missing); midbrain: 73.8510% (minimum 99%, Missing); pancreas: 64.9930% (minimum 99%, Missing); parathyroid gland: 61.0747% (minimum 97%, Missing); pituitary gland: 69.9700% (minimum 99%, Missing); rectum: 63.4014% (minimum 97%, Missing); retina: 77.5374% (minimum 99%, Missing); salivary gland: 59.8972% (minimum 97%, Missing); skeletal muscle: 51.8354% (minimum 98%, Approved); skin: 60.8355% (minimum 95%, Missing); small intestine: 65.4494% (minimum 99%, Missing); smooth muscle: 57.1779% (minimum 98%, Approved); spinal cord: 74.6795% (minimum 99%, Missing); spleen: 69.7605% (minimum 90%, Approved); stomach: 67.8311% (minimum 97%, Missing); thymus: 57.2482% (minimum 95%, Missing); thyroid gland: 55.5423% (minimum 95%, Missing); tongue: 53.6866% (minimum 97%, Missing); urinary bladder: 58.0324% (minimum 97%, Missing)",0,2,partial,43.3,40.2,49.2,"adipose tissue: 49.2 nTPM (manageable, limit 10); skeletal muscle: 43.3 nTPM (vital, limit 2); tongue: 40.2 nTPM (protected, limit 2); esophagus: 39.3 nTPM (protected, limit 4); thyroid gland: 37.3 nTPM (manageable, limit 5); colon: 37.1 nTPM (protected, limit 2); smooth muscle: 34.9 nTPM (vital, limit 2); thymus: 34.8 nTPM (manageable, limit 5); urinary bladder: 33.7 nTPM (protected, limit 2); heart muscle: 33.6 nTPM (vital, limit 2); adrenal gland: 33.4 nTPM (vital, limit 1); salivary gland: 31.2 nTPM (protected, limit 2); lung: 31.1 nTPM (vital, limit 1); skin: 30 nTPM (manageable, limit 5); parathyroid gland: 29.7 nTPM (protected, limit 2); bone marrow: 29.3 nTPM (vital, limit 2); rectum: 26.9 nTPM (protected, limit 2); lymph node: 25.7 nTPM (protected, limit 2); kidney: 25.1 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 2); duodenum: 20.6 nTPM (vital, limit 1); spleen: 20.2 nTPM (manageable, limit 10); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000117868,ESYT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.41357,-0.433134,-0.461646
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.7,1,2.9,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000117971,CHRNB4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.2456% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2456% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.8033% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2456% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.2456% (minimum 99%, Baseline (adaptation disabled)); colon: 84.8485% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.2456% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.3226% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.2456% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.5517% (minimum 99%, Baseline (adaptation disabled)); lung: 98.2456% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.8033% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.2456% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.5517% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 67.4699% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.5517% (minimum 99%, Baseline (adaptation disabled)); small intestine: 93.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.8033% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.5517% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.8824% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2.7,1,2.9,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000117971,CHRNB4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Loriot 2025,-0.291176,-0.121515,-0.315301
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 99%, Missing); amygdala: 98.2456% (minimum 99%, Missing); basal ganglia: 98.2456% (minimum 99%, Missing); bone marrow: 91.8033% (minimum 99%, Missing); cerebral cortex: 98.2456% (minimum 99%, Missing); choroid plexus: 98.2456% (minimum 99%, Missing); colon: 84.8485% (minimum 97%, Missing); duodenum: 98.2456% (minimum 99%, Missing); esophagus: 90.3226% (minimum 97%, Missing); heart muscle: 98.2456% (minimum 99%, Missing); kidney: 96.5517% (minimum 99%, Missing); lung: 98.2456% (minimum 99%, Missing); lymph node: 91.8033% (minimum 97%, Missing); pancreas: 98.2456% (minimum 99%, Missing); parathyroid gland: 96.5517% (minimum 97%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); rectum: 93.3333% (minimum 97%, Missing); retina: 67.4699% (minimum 99%, Missing); skeletal muscle: 96.5517% (minimum 99%, Missing); small intestine: 93.3333% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spleen: 91.8033% (minimum 95%, Missing); stomach: 96.5517% (minimum 97%, Missing); thymus: 65.8824% (minimum 95%, Missing)",0,80,unavailable,2.7,1,2.9,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000117971,CHRNB4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Loriot 2025,-0.291176,-0.121515,-0.315301
True,compatible,,True,True,False,,0,2,partial,3,0.7,1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000118156,ZNF541,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 87.3950% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5782% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.6526% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.6526% (minimum 99%, Baseline (adaptation disabled)); colon: 96.7442% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.2963% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5782% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5782% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.7442% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1963% (minimum 99%, Baseline (adaptation disabled)); retina: 97.6526% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.6526% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,3,0.7,1,"adrenal gland: 3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000118156,ZNF541,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00412844,-0.00255814,-0.11605
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 87.3950% (minimum 95%, Enhanced); amygdala: 98.5782% (minimum 99%, Missing); hippocampal formation: 98.5782% (minimum 99%, Missing); hypothalamus: 98.5782% (minimum 99%, Missing); pituitary gland: 97.1963% (minimum 99%, Missing); retina: 97.6526% (minimum 99%, Missing)",0,2,partial,3,0.7,1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000118156,ZNF541,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0452153,0.0252153,-0.0760504
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.5,3.1,10.6,"thymus: 10.6 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118193,KIF14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3077% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.3077% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 26.9663% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.3077% (minimum 99%, Baseline (adaptation disabled)); colon: 72.7273% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.5882% (minimum 97%, Baseline (adaptation disabled)); liver: 88.8889% (minimum 99%, Baseline (adaptation disabled)); lung: 92.3077% (minimum 99%, Baseline (adaptation disabled)); lymph node: 43.6364% (minimum 97%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 70.5882% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.5882% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 18.4615% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 85.7143% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.5,3.1,10.6,"thymus: 10.6 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118193,KIF14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.765385,-0.533636,-0.720337
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3077% (minimum 95%, Missing); adrenal gland: 92.3077% (minimum 99%, Missing); bone marrow: 26.9663% (minimum 99%, Missing); cerebral cortex: 92.3077% (minimum 99%, Missing); colon: 72.7273% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 70.5882% (minimum 97%, Missing); liver: 88.8889% (minimum 99%, Missing); lung: 92.3077% (minimum 99%, Missing); lymph node: 43.6364% (minimum 97%, Missing); rectum: 66.6667% (minimum 97%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); skin: 70.5882% (minimum 95%, Missing); small intestine: 70.5882% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thymus: 18.4615% (minimum 95%, Missing); urinary bladder: 85.7143% (minimum 97%, Missing)",0,80,unavailable,6.5,3.1,10.6,"thymus: 10.6 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118193,KIF14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.765385,-0.533636,-0.720337
True,compatible,,True,True,False,,0,4,partial,2.3,1,2.3,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000118245,TNP1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,4,partial,2.3,1,2.3,"skeletal muscle: 2.3 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000118245,TNP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0496028,0.0298272,0.00960276
True,compatible,,True,True,True,,0,4,partial,2.3,1,2.3,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000118245,TNP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00986179
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,13.9,3.2,4,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118307,DNAI7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.3799% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.6975% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.9167% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.3799% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6726% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.0928% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 61.6022% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2379% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.5311% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.9194% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.5582% (minimum 99%, Baseline (adaptation disabled)); lung: 92.5311% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.1207% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.9565% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.4510% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.1145% (minimum 99%, Baseline (adaptation disabled)); retina: 81.6850% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6726% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.9565% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.9565% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 84.7909% (minimum 95%, Baseline (adaptation disabled))",0,7,partial,13.9,3.2,4,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118307,DNAI7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.102091,-0.0954902,-0.373978
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.6975% (minimum 99%, Missing); basal ganglia: 92.9167% (minimum 99%, Missing); cerebral cortex: 94.0928% (minimum 95%, Enhanced); choroid plexus: 61.6022% (minimum 99%, Missing); hippocampal formation: 92.5311% (minimum 99%, Missing); hypothalamus: 89.9194% (minimum 99%, Missing); kidney: 89.5582% (minimum 95%, Enhanced); lung: 92.5311% (minimum 99%, Missing); midbrain: 96.1207% (minimum 99%, Missing); pituitary gland: 85.1145% (minimum 99%, Missing); retina: 81.6850% (minimum 99%, Missing); spinal cord: 96.9565% (minimum 99%, Missing); thyroid gland: 84.7909% (minimum 95%, Missing)",0,7,partial,13.9,3.2,4,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118307,DNAI7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.102091,0.03,-0.373978
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,3.3,2.4,2.6,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000118420,UBE3D,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.6056% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.7273% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.8649% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.6056% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.1579% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.3559% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.5652% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.8462% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.4194% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.8462% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.5652% (minimum 99%, Baseline (adaptation disabled)); liver: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 81.3559% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.5652% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.5714% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.6418% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.6056% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 59.2593% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.7273% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 64.8649% (minimum 99%, Baseline (adaptation disabled)); skin: 78.6885% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.4194% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.1905% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.7273% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.8462% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.5652% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.8649% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 70.5882% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,3.3,2.4,2.6,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000118420,UBE3D,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.301351,-0.303333,-0.397407
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.0000% (minimum 90%, Approved); adrenal gland: 67.6056% (minimum 99%, Missing); amygdala: 72.7273% (minimum 99%, Missing); basal ganglia: 64.8649% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 99%, Missing); cerebellum: 67.6056% (minimum 99%, Missing); cerebral cortex: 63.1579% (minimum 99%, Missing); choroid plexus: 81.3559% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 69.5652% (minimum 99%, Missing); esophagus: 73.8462% (minimum 97%, Missing); heart muscle: 77.4194% (minimum 99%, Missing); hippocampal formation: 73.8462% (minimum 99%, Missing); hypothalamus: 64.0000% (minimum 99%, Missing); kidney: 69.5652% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lung: 81.3559% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 69.5652% (minimum 99%, Missing); pancreas: 68.5714% (minimum 99%, Missing); parathyroid gland: 71.6418% (minimum 97%, Missing); pituitary gland: 67.6056% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 59.2593% (minimum 99%, Missing); salivary gland: 72.7273% (minimum 97%, Missing); skeletal muscle: 64.8649% (minimum 99%, Missing); skin: 78.6885% (minimum 95%, Missing); small intestine: 77.4194% (minimum 99%, Missing); smooth muscle: 76.1905% (minimum 99%, Missing); spinal cord: 72.7273% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 73.8462% (minimum 97%, Missing); thymus: 69.5652% (minimum 95%, Missing); thyroid gland: 64.8649% (minimum 95%, Missing); tongue: 66.6667% (minimum 97%, Missing); urinary bladder: 70.5882% (minimum 97%, Missing)",0,3,partial,3.3,2.4,2.6,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000118420,UBE3D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.301351,-0.303333,-0.397407
True,compatible,,True,True,False,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000118434,SPACA1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000118434,SPACA1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.00754902
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000118434,SPACA1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ENSG00000118491,ZC2HC1B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 98.6301% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ENSG00000118491,ZC2HC1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.0363014,0.0231034,-0.00369863
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 98.6301% (minimum 99%, Missing)",0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ENSG00000118491,ZC2HC1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.0363014,0.0231034,-0.00369863
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,4.8,0.3,0,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,not_triggered,,,ENSG00000118492,ADGB,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.3180% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.4887% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.1060% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.4887% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.0741% (minimum 99%, Baseline (adaptation disabled)); lung: 95.1311% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.8327% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8327% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,4.8,0.3,0,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,not_triggered,,,ENSG00000118492,ADGB,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0183268,-0.14894
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.3180% (minimum 99%, Missing); basal ganglia: 95.4887% (minimum 99%, Missing); choroid plexus: 84.1060% (minimum 99%, Missing); hippocampal formation: 95.4887% (minimum 99%, Missing); hypothalamus: 94.0741% (minimum 99%, Missing); pituitary gland: 98.8327% (minimum 99%, Missing); spinal cord: 98.8327% (minimum 99%, Missing)",0,5,partial,4.8,0.3,0,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,not_triggered,,,ENSG00000118492,ADGB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0183268,-0.14894
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,33.2,9.7,19.3,"heart muscle: 33.2 nTPM (vital, limit 2); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 2); pancreas: 9.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 4); lymph node: 4.8 nTPM (protected, limit 4); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 2); smooth muscle: 3.4 nTPM (vital, limit 2); tongue: 3.4 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 2); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000118596,SLC16A7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 16.8103% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 37.1429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.7826% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.7826% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 45.8824% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.9048% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 59.0909% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 66.1017% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.2222% (minimum 99%, Baseline (adaptation disabled)); esophagus: 38.6139% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 10.5121% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.5918% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.7826% (minimum 99%, Baseline (adaptation disabled)); kidney: 25.8278% (minimum 99%, Baseline (adaptation disabled)); liver: 50.6494% (minimum 99%, Baseline (adaptation disabled)); lung: 47.5610% (minimum 99%, Baseline (adaptation disabled)); lymph node: 44.8276% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.2500% (minimum 99%, Baseline (adaptation disabled)); pancreas: 29.3233% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.5918% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.5849% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.9048% (minimum 97%, Baseline (adaptation disabled)); retina: 69.6429% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.0909% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.4211% (minimum 99%, Baseline (adaptation disabled)); skin: 33.9130% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.9048% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.4247% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.9091% (minimum 99%, Baseline (adaptation disabled)); spleen: 39.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 28.6765% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.9880% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.9091% (minimum 95%, Baseline (adaptation disabled)); tongue: 53.4247% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.6494% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,33.2,9.7,19.3,"heart muscle: 33.2 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 2); pancreas: 9.4 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); spleen: 6.1 nTPM (manageable, limit 5); lymph node: 4.8 nTPM (protected, limit 2); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000118596,SLC16A7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.781897,-0.683235,-0.884879
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 16.8103% (minimum 95%, Missing); adrenal gland: 37.1429% (minimum 99%, Missing); amygdala: 84.7826% (minimum 99%, Missing); basal ganglia: 84.7826% (minimum 99%, Missing); bone marrow: 45.8824% (minimum 99%, Missing); cerebellum: 61.9048% (minimum 99%, Missing); cerebral cortex: 59.0909% (minimum 99%, Missing); choroid plexus: 78.0000% (minimum 99%, Missing); colon: 66.1017% (minimum 97%, Missing); duodenum: 72.2222% (minimum 99%, Missing); esophagus: 38.6139% (minimum 95%, Approved); heart muscle: 10.5121% (minimum 98%, Approved); hippocampal formation: 79.5918% (minimum 99%, Missing); hypothalamus: 84.7826% (minimum 99%, Missing); kidney: 25.8278% (minimum 99%, Missing); liver: 50.6494% (minimum 98%, Approved); lung: 47.5610% (minimum 99%, Missing); lymph node: 44.8276% (minimum 95%, Approved); midbrain: 81.2500% (minimum 99%, Missing); pancreas: 29.3233% (minimum 99%, Missing); parathyroid gland: 79.5918% (minimum 97%, Missing); pituitary gland: 73.5849% (minimum 99%, Missing); rectum: 61.9048% (minimum 97%, Missing); retina: 69.6429% (minimum 99%, Missing); salivary gland: 59.0909% (minimum 97%, Missing); skeletal muscle: 68.4211% (minimum 99%, Missing); skin: 33.9130% (minimum 90%, Approved); small intestine: 61.9048% (minimum 98%, Approved); smooth muscle: 53.4247% (minimum 98%, Approved); spinal cord: 70.9091% (minimum 99%, Missing); spleen: 39.0000% (minimum 90%, Approved); stomach: 28.6765% (minimum 97%, Missing); thymus: 46.9880% (minimum 95%, Missing); thyroid gland: 70.9091% (minimum 90%, Approved); tongue: 53.4247% (minimum 97%, Missing); urinary bladder: 50.6494% (minimum 97%, Missing)",0,7,partial,33.2,9.7,19.3,"heart muscle: 33.2 nTPM (vital, limit 2); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 2); pancreas: 9.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 4); lymph node: 4.8 nTPM (protected, limit 4); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 2); smooth muscle: 3.4 nTPM (vital, limit 2); tongue: 3.4 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 2); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000118596,SLC16A7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.781897,-0.683235,-0.874879
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.6,10.1,9.5,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 2); thymus: 9.5 nTPM (manageable, limit 5); thyroid gland: 8.2 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 2); skin: 7.2 nTPM (manageable, limit 5); esophagus: 6.6 nTPM (protected, limit 2); spleen: 6.4 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); cerebellum: 4.1 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118620,ZNF430,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.6978% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.8321% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.7209% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.0563% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.2143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.4832% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.4828% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.4286% (minimum 99%, Baseline (adaptation disabled)); colon: 78.2609% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.0563% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.0690% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.0769% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.3750% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.5970% (minimum 99%, Baseline (adaptation disabled)); liver: 91.5254% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 51.6746% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.4427% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.9730% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.0164% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.4832% (minimum 97%, Baseline (adaptation disabled)); retina: 80.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.0563% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.8049% (minimum 99%, Baseline (adaptation disabled)); skin: 60.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.0563% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.5957% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.1429% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.7907% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.2308% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.2020% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.8421% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.5970% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.0526% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.6,10.1,9.5,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 2); thymus: 9.5 nTPM (manageable, limit 5); thyroid gland: 8.2 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 2); skin: 7.2 nTPM (manageable, limit 5); esophagus: 6.6 nTPM (protected, limit 2); spleen: 6.4 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); cerebellum: 4.1 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118620,ZNF430,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.41798,-0.453254,-0.507857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.6978% (minimum 95%, Missing); adrenal gland: 78.8321% (minimum 99%, Missing); amygdala: 83.7209% (minimum 99%, Missing); basal ganglia: 76.0563% (minimum 99%, Missing); bone marrow: 48.2143% (minimum 99%, Missing); cerebellum: 72.4832% (minimum 99%, Missing); cerebral cortex: 74.4828% (minimum 99%, Missing); choroid plexus: 96.4286% (minimum 99%, Missing); colon: 78.2609% (minimum 97%, Missing); duodenum: 76.0563% (minimum 99%, Missing); esophagus: 62.0690% (minimum 97%, Missing); heart muscle: 85.7143% (minimum 99%, Missing); hippocampal formation: 83.0769% (minimum 99%, Missing); hypothalamus: 84.3750% (minimum 99%, Missing); kidney: 80.5970% (minimum 99%, Missing); liver: 91.5254% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 51.6746% (minimum 97%, Missing); midbrain: 82.4427% (minimum 99%, Missing); pancreas: 72.9730% (minimum 99%, Missing); parathyroid gland: 59.0164% (minimum 97%, Missing); pituitary gland: 85.7143% (minimum 99%, Missing); rectum: 72.4832% (minimum 97%, Missing); retina: 80.0000% (minimum 99%, Missing); salivary gland: 76.0563% (minimum 97%, Missing); skeletal muscle: 87.8049% (minimum 99%, Missing); skin: 60.0000% (minimum 95%, Missing); small intestine: 76.0563% (minimum 99%, Missing); smooth muscle: 76.5957% (minimum 99%, Missing); spinal cord: 77.1429% (minimum 99%, Missing); spleen: 62.7907% (minimum 95%, Missing); stomach: 69.2308% (minimum 97%, Missing); thymus: 53.2020% (minimum 95%, Missing); thyroid gland: 56.8421% (minimum 95%, Missing); tongue: 80.5970% (minimum 97%, Missing); urinary bladder: 71.0526% (minimum 97%, Missing)",0,80,unavailable,11.6,10.1,9.5,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 2); thymus: 9.5 nTPM (manageable, limit 5); thyroid gland: 8.2 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 2); skin: 7.2 nTPM (manageable, limit 5); esophagus: 6.6 nTPM (protected, limit 2); spleen: 6.4 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); cerebellum: 4.1 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118620,ZNF430,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.41798,-0.453254,-0.507857
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,13.1,13.9,8.5,"parathyroid gland: 13.9 nTPM (protected, limit 2); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 2); colon: 4.7 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 4); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); heart muscle: 3.2 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); tongue: 2.5 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 2); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000118965,WDR35,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.8621% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.1824% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.8621% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.9677% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.6154% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.0896% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.7500% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 45.6432% (minimum 99%, Baseline (adaptation disabled)); colon: 70.0637% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.6142% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.7101% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.4648% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.3425% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.5128% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.1398% (minimum 99%, Baseline (adaptation disabled)); liver: 85.2713% (minimum 99%, Baseline (adaptation disabled)); lung: 71.8954% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.8824% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.8299% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.8299% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 44.1767% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.1367% (minimum 97%, Baseline (adaptation disabled)); retina: 47.4138% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.1367% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.0896% (minimum 99%, Baseline (adaptation disabled)); skin: 76.9231% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.1367% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.7059% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.3425% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.6154% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.8621% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.0637% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.4103% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.4815% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.8954% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,13.1,13.9,8.5,"parathyroid gland: 13.9 nTPM (protected, limit 2); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); heart muscle: 3.2 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); tongue: 2.5 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000118965,WDR35,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.385897,-0.528233,-0.533568
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.8621% (minimum 90%, Approved); adrenal gland: 69.1824% (minimum 98%, Approved); amygdala: 75.8621% (minimum 99%, Missing); basal ganglia: 70.9677% (minimum 99%, Missing); bone marrow: 84.6154% (minimum 99%, Missing); cerebellum: 82.0896% (minimum 99%, Missing); cerebral cortex: 68.7500% (minimum 99%, Missing); choroid plexus: 45.6432% (minimum 99%, Missing); colon: 70.0637% (minimum 97%, Missing); duodenum: 86.6142% (minimum 99%, Missing); esophagus: 79.7101% (minimum 97%, Missing); heart muscle: 77.4648% (minimum 99%, Missing); hippocampal formation: 75.3425% (minimum 99%, Missing); hypothalamus: 70.5128% (minimum 99%, Missing); kidney: 59.1398% (minimum 99%, Missing); liver: 85.2713% (minimum 99%, Missing); lung: 71.8954% (minimum 99%, Missing); lymph node: 80.8824% (minimum 97%, Missing); midbrain: 74.8299% (minimum 99%, Missing); pancreas: 74.8299% (minimum 99%, Missing); parathyroid gland: 44.1767% (minimum 97%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); rectum: 79.1367% (minimum 97%, Missing); retina: 47.4138% (minimum 99%, Missing); salivary gland: 79.1367% (minimum 97%, Missing); skeletal muscle: 82.0896% (minimum 98%, Approved); skin: 76.9231% (minimum 95%, Missing); small intestine: 79.1367% (minimum 99%, Missing); smooth muscle: 64.7059% (minimum 98%, Approved); spinal cord: 75.3425% (minimum 99%, Missing); spleen: 84.6154% (minimum 95%, Missing); stomach: 75.8621% (minimum 97%, Missing); thymus: 70.0637% (minimum 95%, Missing); thyroid gland: 56.4103% (minimum 95%, Missing); tongue: 81.4815% (minimum 97%, Missing); urinary bladder: 71.8954% (minimum 95%, Approved)",0,6,partial,13.1,13.9,8.5,"parathyroid gland: 13.9 nTPM (protected, limit 2); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 2); colon: 4.7 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 4); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); heart muscle: 3.2 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); tongue: 2.5 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 2); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000118965,WDR35,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.385897,-0.528233,-0.533568
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,20.4,1.9,3.1,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 6); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118997,DNAH7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.1053% (minimum 99%, Baseline (adaptation disabled)); amygdala: 66.0377% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.2632% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.3303% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.5000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 33.9806% (minimum 99%, Baseline (adaptation disabled)); colon: 94.5946% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.3303% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 69.5364% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.0789% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.0870% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2222% (minimum 99%, Baseline (adaptation disabled)); lung: 82.6772% (minimum 99%, Baseline (adaptation disabled)); midbrain: 78.3582% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.1527% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.6774% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.4545% (minimum 97%, Baseline (adaptation disabled)); retina: 54.6875% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.9204% (minimum 97%, Baseline (adaptation disabled)); small intestine: 93.7500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.2222% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.9204% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.5946% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 77.2059% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,20.4,1.9,3.1,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118997,DNAH7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.177941,-0.123226,-0.650194
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.1053% (minimum 99%, Missing); amygdala: 66.0377% (minimum 99%, Missing); basal ganglia: 55.2632% (minimum 99%, Missing); cerebral cortex: 62.5000% (minimum 95%, Enhanced); choroid plexus: 33.9806% (minimum 99%, Missing); hippocampal formation: 69.5364% (minimum 99%, Missing); hypothalamus: 69.0789% (minimum 99%, Missing); kidney: 76.0870% (minimum 95%, Enhanced); lung: 82.6772% (minimum 95%, Enhanced); midbrain: 78.3582% (minimum 99%, Missing); pancreas: 80.1527% (minimum 95%, Enhanced); pituitary gland: 60.0000% (minimum 99%, Missing); retina: 54.6875% (minimum 99%, Missing); small intestine: 93.7500% (minimum 95%, Enhanced); spinal cord: 92.9204% (minimum 99%, Missing); stomach: 94.5946% (minimum 97%, Missing); thyroid gland: 77.2059% (minimum 95%, Missing)",0,6,partial,20.4,1.9,3.1,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 6); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000118997,DNAH7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.177941,-0.0240541,-0.650194
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,16.9,11.7,10.3,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 2); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); thymus: 10.3 nTPM (manageable, limit 5); spleen: 10.2 nTPM (manageable, limit 5); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 2); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); urinary bladder: 8.7 nTPM (protected, limit 2); parathyroid gland: 8.5 nTPM (protected, limit 2); esophagus: 8.2 nTPM (protected, limit 2); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); stomach: 8 nTPM (protected, limit 2); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 7.6 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000119231,SENP5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.1429% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.8148% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.5585% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.4746% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 56.4246% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.5826% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.7224% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0929% (minimum 99%, Baseline (adaptation disabled)); colon: 67.1096% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.9923% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.1268% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.1781% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.1613% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.5387% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.6619% (minimum 99%, Baseline (adaptation disabled)); liver: 67.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 67.7852% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.6552% (minimum 97%, Baseline (adaptation disabled)); midbrain: 65.3722% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.1429% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.3833% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.8874% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.0929% (minimum 97%, Baseline (adaptation disabled)); retina: 54.4474% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.9242% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.9241% (minimum 99%, Baseline (adaptation disabled)); skin: 68.9420% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.3781% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.6619% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.5844% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.4474% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.6312% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.2295% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.3781% (minimum 95%, Baseline (adaptation disabled)); tongue: 63.3229% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.8962% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,16.9,11.7,10.3,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 2); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); thymus: 10.3 nTPM (manageable, limit 5); spleen: 10.2 nTPM (manageable, limit 5); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 2); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); urinary bladder: 8.7 nTPM (protected, limit 2); parathyroid gland: 8.5 nTPM (protected, limit 2); esophagus: 8.2 nTPM (protected, limit 2); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); stomach: 8 nTPM (protected, limit 2); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 7.6 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000119231,SENP5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.287705,-0.336771,-0.445526
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.1429% (minimum 95%, Missing); adrenal gland: 74.8148% (minimum 99%, Missing); amygdala: 67.5585% (minimum 99%, Missing); basal ganglia: 68.4746% (minimum 99%, Missing); bone marrow: 56.4246% (minimum 99%, Missing); cerebellum: 56.5826% (minimum 99%, Missing); cerebral cortex: 63.7224% (minimum 99%, Missing); choroid plexus: 75.0929% (minimum 99%, Missing); colon: 67.1096% (minimum 97%, Missing); duodenum: 77.9923% (minimum 99%, Missing); esophagus: 71.1268% (minimum 97%, Missing); heart muscle: 69.1781% (minimum 99%, Missing); hippocampal formation: 65.1613% (minimum 99%, Missing); hypothalamus: 62.5387% (minimum 99%, Missing); kidney: 72.6619% (minimum 99%, Missing); liver: 67.3333% (minimum 99%, Missing); lung: 67.7852% (minimum 99%, Missing); lymph node: 69.6552% (minimum 97%, Missing); midbrain: 65.3722% (minimum 99%, Missing); pancreas: 72.1429% (minimum 99%, Missing); parathyroid gland: 70.3833% (minimum 97%, Missing); pituitary gland: 66.8874% (minimum 99%, Missing); rectum: 75.0929% (minimum 97%, Missing); retina: 54.4474% (minimum 99%, Missing); salivary gland: 72.9242% (minimum 97%, Missing); skeletal muscle: 63.9241% (minimum 99%, Missing); skin: 68.9420% (minimum 95%, Missing); small intestine: 71.3781% (minimum 99%, Missing); smooth muscle: 72.6619% (minimum 99%, Missing); spinal cord: 65.5844% (minimum 99%, Missing); spleen: 66.4474% (minimum 95%, Missing); stomach: 71.6312% (minimum 97%, Missing); thymus: 66.2295% (minimum 95%, Missing); thyroid gland: 71.3781% (minimum 95%, Missing); tongue: 63.3229% (minimum 97%, Missing); urinary bladder: 69.8962% (minimum 97%, Missing)",0,80,unavailable,16.9,11.7,10.3,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 2); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); thymus: 10.3 nTPM (manageable, limit 5); spleen: 10.2 nTPM (manageable, limit 5); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 2); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); urinary bladder: 8.7 nTPM (protected, limit 2); parathyroid gland: 8.5 nTPM (protected, limit 2); esophagus: 8.2 nTPM (protected, limit 2); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); stomach: 8 nTPM (protected, limit 2); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 7.6 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000119231,SENP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.287705,-0.336771,-0.445526
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,3,partial,9.9,0.8,0,"duodenum: 9.9 nTPM (vital, limit 6); liver: 8.2 nTPM (vital, limit 6); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Enhanced),52,not_established,required,in_situ_inflammation_review,gallbladder; gallbladder / glandular cells,ENSG00000119547,ONECUT2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 2.9412% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 12.5000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 20.0000% (minimum 99%, Baseline (adaptation disabled)); duodenum: 1.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 25.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 1.2048% (minimum 99%, Baseline (adaptation disabled)); pancreas: 4.1667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 11.1111% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 11.1111% (minimum 99%, Baseline (adaptation disabled)); retina: 1.8519% (minimum 99%, Baseline (adaptation disabled)); small intestine: 4.5455% (minimum 99%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,9.9,0.8,0,"duodenum: 9.9 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Enhanced),52,not_established,required,in_situ_inflammation_review,gallbladder; gallbladder / glandular cells,ENSG00000119547,ONECUT2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,-0.858889,-0.98
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 50.0000% (minimum 95%, Enhanced); basal ganglia: 2.9412% (minimum 99%, Missing); cerebellum: 12.5000% (minimum 95%, Enhanced); cerebral cortex: 20.0000% (minimum 95%, Enhanced); duodenum: 1.0000% (minimum 95%, Enhanced); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 25.0000% (minimum 99%, Missing); kidney: 50.0000% (minimum 95%, Enhanced); liver: 1.2048% (minimum 95%, Enhanced); pancreas: 4.1667% (minimum 95%, Enhanced); parathyroid gland: 11.1111% (minimum 80%, Enhanced); pituitary gland: 11.1111% (minimum 99%, Missing); retina: 1.8519% (minimum 99%, Missing); small intestine: 4.5455% (minimum 99%, Missing); stomach: 50.0000% (minimum 80%, Enhanced)",0,3,partial,9.9,0.8,0,"duodenum: 9.9 nTPM (vital, limit 6); liver: 8.2 nTPM (vital, limit 6); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Enhanced),52,not_established,required,in_situ_inflammation_review,gallbladder; gallbladder / glandular cells,ENSG00000119547,ONECUT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,-0.688889,-0.971481
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,42.3,19.8,23.1,"cerebral cortex: 42.3 nTPM (vital, limit 2); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 2); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (manageable, limit 5); spleen: 22.8 nTPM (manageable, limit 10); adrenal gland: 22.8 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 2); pancreas: 19.4 nTPM (vital, limit 2); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); stomach: 17.3 nTPM (protected, limit 2); small intestine: 17.2 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 2); urinary bladder: 16.9 nTPM (protected, limit 2); skin: 16.8 nTPM (manageable, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 2); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 2); lymph node: 14.5 nTPM (protected, limit 4); lung: 14.3 nTPM (vital, limit 2); adipose tissue: 13.9 nTPM (manageable, limit 10); thymus: 9.2 nTPM (manageable, limit 5); bone marrow: 7.7 nTPM (vital, limit 2); tongue: 7.2 nTPM (protected, limit 2); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 2); rectum: 4.9 nTPM (protected, limit 2)",bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000119559,C19orf25,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.7345% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 48.5327% (minimum 99%, Baseline (adaptation disabled)); amygdala: 33.9652% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 37.0690% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.6301% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.1727% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 33.6991% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 54.2929% (minimum 99%, Baseline (adaptation disabled)); colon: 55.2699% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.7432% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.0581% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.0689% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 35.1307% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 38.1206% (minimum 99%, Baseline (adaptation disabled)); kidney: 41.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 42.8287% (minimum 99%, Baseline (adaptation disabled)); lung: 60.0559% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.7222% (minimum 97%, Baseline (adaptation disabled)); midbrain: 35.3038% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.5672% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.9041% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 44.8852% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.4394% (minimum 97%, Baseline (adaptation disabled)); retina: 76.2411% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.6995% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 57.9515% (minimum 99%, Baseline (adaptation disabled)); skin: 56.1358% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.5556% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.7546% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 35.8932% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.5327% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.4124% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.0326% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.2063% (minimum 95%, Baseline (adaptation disabled)); tongue: 74.9129% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.9896% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,42.3,19.8,23.1,"cerebral cortex: 42.3 nTPM (vital, limit 1); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 1); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (manageable, limit 5); spleen: 22.8 nTPM (manageable, limit 5); adrenal gland: 22.8 nTPM (vital, limit 1); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 2); pancreas: 19.4 nTPM (vital, limit 1); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); stomach: 17.3 nTPM (protected, limit 2); small intestine: 17.2 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 2); urinary bladder: 16.9 nTPM (protected, limit 2); skin: 16.8 nTPM (manageable, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 1); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 2); lymph node: 14.5 nTPM (protected, limit 2); lung: 14.3 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); bone marrow: 7.7 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 2)",bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000119559,C19orf25,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.467937,-0.449419,-0.653009
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.7345% (minimum 90%, Approved); adrenal gland: 48.5327% (minimum 98%, Approved); amygdala: 33.9652% (minimum 99%, Missing); basal ganglia: 37.0690% (minimum 99%, Missing); bone marrow: 73.6301% (minimum 98%, Approved); cerebellum: 43.1727% (minimum 98%, Approved); cerebral cortex: 33.6991% (minimum 98%, Approved); choroid plexus: 54.2929% (minimum 99%, Missing); colon: 55.2699% (minimum 97%, Missing); duodenum: 58.7432% (minimum 99%, Missing); esophagus: 52.0581% (minimum 97%, Missing); heart muscle: 51.0689% (minimum 99%, Missing); hippocampal formation: 35.1307% (minimum 99%, Missing); hypothalamus: 38.1206% (minimum 99%, Missing); kidney: 41.6667% (minimum 99%, Missing); liver: 42.8287% (minimum 99%, Missing); lung: 60.0559% (minimum 98%, Approved); lymph node: 59.7222% (minimum 95%, Approved); midbrain: 35.3038% (minimum 99%, Missing); pancreas: 52.5672% (minimum 98%, Approved); parathyroid gland: 58.9041% (minimum 97%, Missing); pituitary gland: 44.8852% (minimum 99%, Missing); rectum: 81.4394% (minimum 97%, Missing); retina: 76.2411% (minimum 99%, Missing); salivary gland: 55.6995% (minimum 97%, Missing); skeletal muscle: 57.9515% (minimum 98%, Approved); skin: 56.1358% (minimum 95%, Missing); small intestine: 55.5556% (minimum 99%, Missing); smooth muscle: 78.7546% (minimum 98%, Approved); spinal cord: 35.8932% (minimum 99%, Missing); spleen: 48.5327% (minimum 90%, Approved); stomach: 55.4124% (minimum 97%, Missing); thymus: 70.0326% (minimum 95%, Missing); thyroid gland: 48.2063% (minimum 95%, Missing); tongue: 74.9129% (minimum 97%, Missing); urinary bladder: 55.9896% (minimum 97%, Missing)",0,4,partial,42.3,19.8,23.1,"cerebral cortex: 42.3 nTPM (vital, limit 2); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 2); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (manageable, limit 5); spleen: 22.8 nTPM (manageable, limit 10); adrenal gland: 22.8 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 2); pancreas: 19.4 nTPM (vital, limit 2); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); stomach: 17.3 nTPM (protected, limit 2); small intestine: 17.2 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 2); urinary bladder: 16.9 nTPM (protected, limit 2); skin: 16.8 nTPM (manageable, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 2); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 2); lymph node: 14.5 nTPM (protected, limit 4); lung: 14.3 nTPM (vital, limit 2); adipose tissue: 13.9 nTPM (manageable, limit 10); thymus: 9.2 nTPM (manageable, limit 5); bone marrow: 7.7 nTPM (vital, limit 2); tongue: 7.2 nTPM (protected, limit 2); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 2); rectum: 4.9 nTPM (protected, limit 2)",bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000119559,C19orf25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.467937,-0.449419,-0.650348
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,17.3,14,15.6,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (manageable, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 2); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); pituitary gland: 8.2 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7.1 nTPM (vital, limit 2); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 2); urinary bladder: 5.9 nTPM (protected, limit 2); thymus: 5.8 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); cerebellum: 5.1 nTPM (vital, limit 2); bone marrow: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 2); spinal cord: 4.7 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 4); salivary gland: 4.3 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 4); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000119661,DNAL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 88.1864% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.8305% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.4808% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.7483% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.2220% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.2220% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.8125% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.8267% (minimum 99%, Baseline (adaptation disabled)); colon: 92.1739% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.3237% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.6573% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.8995% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.7483% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.7483% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.0721% (minimum 99%, Baseline (adaptation disabled)); liver: 93.8053% (minimum 99%, Baseline (adaptation disabled)); lung: 88.1864% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.8544% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.1361% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.5983% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.1045% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.6013% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.3793% (minimum 97%, Baseline (adaptation disabled)); retina: 75.3912% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.4956% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.6955% (minimum 99%, Baseline (adaptation disabled)); skin: 94.9821% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.9821% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.6220% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.8544% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.1739% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.7534% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.1361% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 77.2595% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.2896% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.9830% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,17.3,14,15.6,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (manageable, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 2); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); heart muscle: 8.7 nTPM (vital, limit 1); pituitary gland: 8.2 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7.1 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 2); thymus: 5.8 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); cerebellum: 5.1 nTPM (vital, limit 1); bone marrow: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); salivary gland: 4.3 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000119661,DNAL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.177405,-0.178955,-0.236088
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 88.1864% (minimum 95%, Missing); adrenal gland: 89.8305% (minimum 98%, Approved); amygdala: 88.4808% (minimum 99%, Missing); basal ganglia: 87.7483% (minimum 99%, Missing); bone marrow: 91.2220% (minimum 99%, Missing); cerebellum: 91.2220% (minimum 98%, Approved); cerebral cortex: 82.8125% (minimum 99%, Missing); choroid plexus: 77.8267% (minimum 99%, Missing); colon: 92.1739% (minimum 95%, Approved); duodenum: 95.3237% (minimum 98%, Approved); esophagus: 92.6573% (minimum 95%, Approved); heart muscle: 85.8995% (minimum 99%, Missing); hippocampal formation: 87.7483% (minimum 99%, Missing); hypothalamus: 87.7483% (minimum 99%, Missing); kidney: 83.0721% (minimum 99%, Missing); liver: 93.8053% (minimum 99%, Missing); lung: 88.1864% (minimum 98%, Approved); lymph node: 91.8544% (minimum 97%, Missing); midbrain: 90.1361% (minimum 99%, Missing); pancreas: 90.5983% (minimum 99%, Missing); parathyroid gland: 79.1045% (minimum 97%, Missing); pituitary gland: 86.6013% (minimum 99%, Missing); rectum: 91.3793% (minimum 97%, Missing); retina: 75.3912% (minimum 99%, Missing); salivary gland: 92.4956% (minimum 97%, Missing); skeletal muscle: 91.6955% (minimum 98%, Approved); small intestine: 94.9821% (minimum 98%, Approved); smooth muscle: 85.6220% (minimum 98%, Approved); spinal cord: 91.8544% (minimum 99%, Missing); stomach: 90.7534% (minimum 97%, Missing); thymus: 90.1361% (minimum 95%, Missing); thyroid gland: 77.2595% (minimum 95%, Missing); tongue: 90.2896% (minimum 97%, Missing); urinary bladder: 89.9830% (minimum 97%, Missing)",0,6,partial,17.3,14,15.6,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (manageable, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 2); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); pituitary gland: 8.2 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7.1 nTPM (vital, limit 2); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 2); urinary bladder: 5.9 nTPM (protected, limit 2); thymus: 5.8 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); cerebellum: 5.1 nTPM (vital, limit 2); bone marrow: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 2); spinal cord: 4.7 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 4); salivary gland: 4.3 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 4); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000119661,DNAL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.177405,-0.178955,-0.236088
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,8.5,6.7,6.8,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 6); pituitary gland: 6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000119703,ZC2HC1C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.5516% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.0442% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.5862% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.4592% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.5423% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.3344% (minimum 99%, Baseline (adaptation disabled)); colon: 95.3819% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.7090% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 91.3265% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.8763% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.3913% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.0169% (minimum 99%, Baseline (adaptation disabled)); liver: 86.7528% (minimum 99%, Baseline (adaptation disabled)); lung: 95.7219% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.2105% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.4821% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.9073% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 89.9497% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.8929% (minimum 97%, Baseline (adaptation disabled)); retina: 95.5516% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0442% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.2680% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.8929% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.3516% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.7219% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 88.7603% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,8.5,6.7,6.8,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); parathyroid gland: 6.7 nTPM (protected, limit 2); pituitary gland: 6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000119703,ZC2HC1C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0623967,-0.0809272,-0.126656
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.0442% (minimum 99%, Missing); basal ganglia: 92.5862% (minimum 99%, Missing); cerebellum: 97.4592% (minimum 99%, Missing); cerebral cortex: 94.5423% (minimum 99%, Missing); choroid plexus: 86.3344% (minimum 99%, Missing); colon: 95.3819% (minimum 97%, Missing); duodenum: 94.7090% (minimum 95%, Enhanced); heart muscle: 91.3265% (minimum 95%, Enhanced); hippocampal formation: 94.8763% (minimum 99%, Missing); hypothalamus: 93.3913% (minimum 99%, Missing); kidney: 91.0169% (minimum 95%, Enhanced); liver: 86.7528% (minimum 95%, Enhanced); midbrain: 94.2105% (minimum 99%, Missing); pancreas: 91.4821% (minimum 95%, Enhanced); pituitary gland: 89.9497% (minimum 99%, Missing); retina: 95.5516% (minimum 99%, Missing); skeletal muscle: 92.2680% (minimum 95%, Enhanced); smooth muscle: 98.3516% (minimum 99%, Missing); spinal cord: 95.7219% (minimum 99%, Missing)",0,6,partial,8.5,6.7,6.8,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 6); pituitary gland: 6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000119703,ZC2HC1C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.010644,-0.0161812,-0.126656
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,57,32.4,36.4,"bone marrow: 57 nTPM (vital, limit 1); skin: 36.4 nTPM (manageable, limit 5); esophagus: 32.4 nTPM (protected, limit 2); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 2); thymus: 28.9 nTPM (manageable, limit 5); urinary bladder: 28.1 nTPM (protected, limit 2); liver: 28 nTPM (vital, limit 1); adipose tissue: 28 nTPM (manageable, limit 5); lung: 26.7 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 2); spleen: 25.5 nTPM (manageable, limit 5); lymph node: 25.1 nTPM (protected, limit 2); stomach: 24.9 nTPM (protected, limit 2); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (manageable, limit 5); salivary gland: 23.7 nTPM (protected, limit 2); rectum: 23.4 nTPM (protected, limit 2); retina: 22 nTPM (vital, limit 1); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); spinal cord: 18.3 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 2); midbrain: 17.7 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000119725,ZNF410,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9484% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.7279% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.9934% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.8750% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 43.3962% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.1122% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 71.9934% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.7366% (minimum 99%, Baseline (adaptation disabled)); colon: 59.6995% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.2572% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.4244% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.3881% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.3221% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.4454% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.7279% (minimum 99%, Baseline (adaptation disabled)); liver: 60.9484% (minimum 99%, Baseline (adaptation disabled)); lung: 62.0739% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.5174% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.1726% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.6028% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.6973% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.5179% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.1267% (minimum 97%, Baseline (adaptation disabled)); retina: 66.5145% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.8368% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.2812% (minimum 99%, Baseline (adaptation disabled)); skin: 54.5568% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.0762% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.0739% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.4839% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.1503% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.7026% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.1928% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.7407% (minimum 95%, Baseline (adaptation disabled)); tongue: 71.1726% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.8635% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,57,32.4,36.4,"bone marrow: 57 nTPM (vital, limit 1); skin: 36.4 nTPM (manageable, limit 5); esophagus: 32.4 nTPM (protected, limit 2); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 2); thymus: 28.9 nTPM (manageable, limit 5); urinary bladder: 28.1 nTPM (protected, limit 2); liver: 28 nTPM (vital, limit 1); adipose tissue: 28 nTPM (manageable, limit 5); lung: 26.7 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 2); spleen: 25.5 nTPM (manageable, limit 5); lymph node: 25.1 nTPM (protected, limit 2); stomach: 24.9 nTPM (protected, limit 2); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (manageable, limit 5); salivary gland: 23.7 nTPM (protected, limit 2); rectum: 23.4 nTPM (protected, limit 2); retina: 22 nTPM (vital, limit 1); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); spinal cord: 18.3 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 2); midbrain: 17.7 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000119725,ZNF410,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.404432,-0.395756,-0.556038
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9484% (minimum 95%, Missing); adrenal gland: 57.7279% (minimum 99%, Missing); amygdala: 71.9934% (minimum 99%, Missing); basal ganglia: 71.8750% (minimum 99%, Missing); bone marrow: 43.3962% (minimum 99%, Missing); cerebellum: 72.1122% (minimum 99%, Missing); cerebral cortex: 71.9934% (minimum 99%, Missing); choroid plexus: 58.7366% (minimum 99%, Missing); colon: 59.6995% (minimum 97%, Missing); duodenum: 70.2572% (minimum 99%, Missing); esophagus: 57.4244% (minimum 97%, Missing); heart muscle: 68.3881% (minimum 99%, Missing); hippocampal formation: 73.3221% (minimum 99%, Missing); hypothalamus: 73.4454% (minimum 99%, Missing); kidney: 57.7279% (minimum 99%, Missing); liver: 60.9484% (minimum 99%, Missing); lung: 62.0739% (minimum 99%, Missing); lymph node: 63.5174% (minimum 97%, Missing); midbrain: 71.1726% (minimum 99%, Missing); pancreas: 68.6028% (minimum 99%, Missing); parathyroid gland: 62.6973% (minimum 97%, Missing); pituitary gland: 62.5179% (minimum 99%, Missing); rectum: 65.1267% (minimum 97%, Missing); retina: 66.5145% (minimum 99%, Missing); salivary gland: 64.8368% (minimum 97%, Missing); skeletal muscle: 68.2812% (minimum 99%, Missing); skin: 54.5568% (minimum 95%, Missing); small intestine: 64.0762% (minimum 99%, Missing); smooth muscle: 62.0739% (minimum 99%, Missing); spinal cord: 70.4839% (minimum 99%, Missing); spleen: 63.1503% (minimum 95%, Missing); stomach: 63.7026% (minimum 97%, Missing); thymus: 60.1928% (minimum 95%, Missing); thyroid gland: 64.7407% (minimum 95%, Missing); tongue: 71.1726% (minimum 97%, Missing); urinary bladder: 60.8635% (minimum 97%, Missing)",0,80,unavailable,57,32.4,36.4,"bone marrow: 57 nTPM (vital, limit 1); skin: 36.4 nTPM (manageable, limit 5); esophagus: 32.4 nTPM (protected, limit 2); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 2); thymus: 28.9 nTPM (manageable, limit 5); urinary bladder: 28.1 nTPM (protected, limit 2); liver: 28 nTPM (vital, limit 1); adipose tissue: 28 nTPM (manageable, limit 5); lung: 26.7 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 2); spleen: 25.5 nTPM (manageable, limit 5); lymph node: 25.1 nTPM (protected, limit 2); stomach: 24.9 nTPM (protected, limit 2); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (manageable, limit 5); salivary gland: 23.7 nTPM (protected, limit 2); rectum: 23.4 nTPM (protected, limit 2); retina: 22 nTPM (vital, limit 1); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); spinal cord: 18.3 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 2); midbrain: 17.7 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000119725,ZNF410,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.404432,-0.395756,-0.556038
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,3.2,0.7,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120051,CFAP58,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5882% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.5882% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.5493% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.0149% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.2963% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.2469% (minimum 99%, Baseline (adaptation disabled)); colon: 96.2963% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.8710% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.8571% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.5493% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.8905% (minimum 99%, Baseline (adaptation disabled)); lung: 90.9091% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.0149% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7444% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.5882% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.2778% (minimum 99%, Baseline (adaptation disabled)); retina: 96.2963% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 91.5493% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.4848% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.5882% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.7444% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 94.8905% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.8905% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,3.2,0.7,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120051,CFAP58,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00109489,-0.0210949,-0.187531
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5882% (minimum 98%, Approved); amygdala: 95.5882% (minimum 99%, Missing); basal ganglia: 91.5493% (minimum 99%, Missing); bone marrow: 97.0149% (minimum 98%, Approved); cerebral cortex: 96.2963% (minimum 98%, Approved); choroid plexus: 80.2469% (minimum 99%, Missing); heart muscle: 83.8710% (minimum 98%, Approved); hippocampal formation: 92.8571% (minimum 99%, Missing); hypothalamus: 91.5493% (minimum 99%, Missing); kidney: 94.8905% (minimum 98%, Approved); lung: 90.9091% (minimum 98%, Approved); midbrain: 97.0149% (minimum 99%, Missing); pancreas: 97.7444% (minimum 98%, Approved); pituitary gland: 90.2778% (minimum 99%, Missing); retina: 96.2963% (minimum 99%, Missing); skeletal muscle: 91.5493% (minimum 98%, Approved); smooth muscle: 95.5882% (minimum 98%, Approved); spinal cord: 97.7444% (minimum 99%, Missing); tongue: 94.8905% (minimum 97%, Missing)",0,2,partial,3.2,0.7,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120051,CFAP58,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0423664,-0.0210949,-0.187531
True,compatible,,True,True,False,,0,2,partial,0.6,0.3,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000120160,EQTN,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.6559% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9218% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.9218% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.3914% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.6,0.3,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000120160,EQTN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0445799,0.0218919,-0.00608579
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.6559% (minimum 99%, Missing); spinal cord: 98.3914% (minimum 99%, Missing)",0,2,partial,0.6,0.3,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000120160,EQTN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0272826,-0.00608579
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,6.4,1,1.1,"retina: 6.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000120210,INSL6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6301% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.1392% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.2973% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.9592% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.6443% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.5065% (minimum 97%, Baseline (adaptation disabled)); retina: 69.2308% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.9592% (minimum 99%, Baseline (adaptation disabled)); skin: 93.5065% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.6301% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.9032% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.6443% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,6.4,1,1.1,"retina: 6.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000120210,INSL6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.0209677,-0.0349351,-0.297692
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.1392% (minimum 95%, Enhanced); retina: 69.2308% (minimum 99%, Missing)",0,4,partial,6.4,1,1.1,"retina: 6.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000120210,INSL6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.297692
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ENSG00000120211,INSL4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.0892% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ENSG00000120211,INSL4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0371795,0.0235484,-0.00910828
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.0892% (minimum 99%, Missing)",0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ENSG00000120211,INSL4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0371795,0.0235484,-0.00910828
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,0.7,1,41.8,"skin: 41.8 nTPM (manageable, limit 5)",retina / pigment epithelial cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / melanocytes; spleen; thymus,ENSG00000120215,MLANA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0,Seager 2024,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.8571% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.8571% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.8571% (minimum 99%, Baseline (adaptation disabled)); colon: 92.8571% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.8571% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.2500% (minimum 99%, Baseline (adaptation disabled)); liver: 76.4706% (minimum 99%, Baseline (adaptation disabled)); lung: 92.8571% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.4706% (minimum 97%, Baseline (adaptation disabled)); pancreas: 92.8571% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.8571% (minimum 99%, Baseline (adaptation disabled)); retina: 81.2500% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.5217% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 3.0162% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.4706% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.8571% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.6667% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 86.6667% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,0.7,1,41.8,"skin: 41.8 nTPM (manageable, limit 5)",retina / pigment epithelial cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / melanocytes; spleen; thymus,ENSG00000120215,MLANA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0,Seager 2024,-0.919838,-0.404783,-0.34
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 86.6667% (minimum 95%, Enhanced); bone marrow: 65.0000% (minimum 95%, Enhanced); cerebellum: 92.8571% (minimum 95%, Enhanced); cerebral cortex: 92.8571% (minimum 95%, Enhanced); duodenum: 92.8571% (minimum 95%, Enhanced); heart muscle: 92.8571% (minimum 95%, Enhanced); kidney: 81.2500% (minimum 95%, Enhanced); liver: 76.4706% (minimum 95%, Enhanced); lung: 92.8571% (minimum 95%, Enhanced); lymph node: 76.4706% (minimum 80%, Enhanced); pancreas: 92.8571% (minimum 95%, Enhanced); pituitary gland: 92.8571% (minimum 99%, Missing); retina: 81.2500% (minimum 99%, Missing); salivary gland: 56.5217% (minimum 80%, Enhanced); skeletal muscle: 86.6667% (minimum 95%, Enhanced); skin: 3.0162% (minimum 95%, Missing); small intestine: 92.8571% (minimum 95%, Enhanced); spinal cord: 76.4706% (minimum 99%, Missing); thymus: 92.8571% (minimum 95%, Missing)",0,6,partial,0.7,1,41.8,"skin: 41.8 nTPM (manageable, limit 5)",retina / pigment epithelial cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / melanocytes; spleen; thymus,ENSG00000120215,MLANA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0,Seager 2024,-0.919838,-0.234783,-0.3
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,11.4,1.6,5.4,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120262,CCDC170,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.7847% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.0110% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.5904% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.8580% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.4802% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.9726% (minimum 99%, Baseline (adaptation disabled)); duodenum: 92.8367% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.8852% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.1424% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.2941% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.8852% (minimum 99%, Baseline (adaptation disabled)); liver: 96.1424% (minimum 99%, Baseline (adaptation disabled)); lung: 89.0110% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.8580% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.8852% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.7164% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.2973% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7805% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.9130% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.2941% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 85.7143% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.7164% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,11.4,1.6,5.4,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); adrenal gland: 4 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120262,CCDC170,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0928571,-0.0170588,-0.250274
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 89.0110% (minimum 95%, Enhanced); amygdala: 97.5904% (minimum 99%, Missing); basal ganglia: 95.8580% (minimum 99%, Missing); choroid plexus: 73.9726% (minimum 99%, Missing); duodenum: 92.8367% (minimum 95%, Enhanced); hippocampal formation: 96.1424% (minimum 99%, Missing); hypothalamus: 95.2941% (minimum 99%, Missing); lung: 89.0110% (minimum 95%, Enhanced); midbrain: 97.8852% (minimum 99%, Missing); smooth muscle: 97.2973% (minimum 99%, Missing); spinal cord: 98.7805% (minimum 99%, Missing); thyroid gland: 85.7143% (minimum 95%, Missing)",0,7,partial,11.4,1.6,5.4,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120262,CCDC170,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0928571,0.0269231,-0.250274
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000120289,MAGEB4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000120289,MAGEB4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000120289,MAGEB4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000120329,SLC25A2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.4615% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.4615% (minimum 99%, Baseline (adaptation disabled)); liver: 96.9697% (minimum 99%, Baseline (adaptation disabled)); lung: 98.4615% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.4615% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.9697% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000120329,SLC25A2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;da Silva 2017,0.019697,0.0146154,-0.020303
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.4615% (minimum 99%, Missing); kidney: 98.4615% (minimum 99%, Missing); liver: 96.9697% (minimum 99%, Missing); lung: 98.4615% (minimum 99%, Missing); pancreas: 98.4615% (minimum 99%, Missing); pituitary gland: 96.9697% (minimum 99%, Missing)",0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000120329,SLC25A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;da Silva 2017,0.019697,0.0146154,-0.020303
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,9.3,6.3,8.5,"bone marrow: 9.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 2); rectum: 2.8 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); duodenum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000120334,CENPL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4561% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.6792% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.5238% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.5238% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 50.2674% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.1569% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.0370% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.1569% (minimum 99%, Baseline (adaptation disabled)); colon: 80.3419% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.7391% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.0345% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.4545% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.3846% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.5238% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.0370% (minimum 99%, Baseline (adaptation disabled)); liver: 91.2621% (minimum 99%, Baseline (adaptation disabled)); lung: 87.8505% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.8726% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.5238% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.0693% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.5238% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.0492% (minimum 97%, Baseline (adaptation disabled)); retina: 86.2385% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.8505% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.0370% (minimum 99%, Baseline (adaptation disabled)); skin: 81.7391% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.6847% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.0345% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.8505% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.7391% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.7391% (minimum 97%, Baseline (adaptation disabled)); thymus: 52.5140% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.4545% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.7391% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.9286% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,9.3,6.3,8.5,"bone marrow: 9.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 2); rectum: 2.8 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); duodenum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000120334,CENPL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.42486,-0.371274,-0.487326
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4561% (minimum 95%, Missing); adrenal gland: 88.6792% (minimum 99%, Missing); amygdala: 89.5238% (minimum 99%, Missing); basal ganglia: 89.5238% (minimum 99%, Missing); bone marrow: 50.2674% (minimum 99%, Missing); cerebellum: 92.1569% (minimum 99%, Missing); cerebral cortex: 87.0370% (minimum 99%, Missing); choroid plexus: 92.1569% (minimum 99%, Missing); colon: 80.3419% (minimum 97%, Missing); duodenum: 81.7391% (minimum 99%, Missing); esophagus: 81.0345% (minimum 97%, Missing); heart muscle: 85.4545% (minimum 99%, Missing); hippocampal formation: 90.3846% (minimum 99%, Missing); hypothalamus: 89.5238% (minimum 99%, Missing); kidney: 87.0370% (minimum 99%, Missing); liver: 91.2621% (minimum 99%, Missing); lung: 87.8505% (minimum 99%, Missing); lymph node: 59.8726% (minimum 97%, Missing); midbrain: 89.5238% (minimum 99%, Missing); pancreas: 93.0693% (minimum 99%, Missing); parathyroid gland: 89.5238% (minimum 97%, Uncertain); pituitary gland: 94.0000% (minimum 99%, Missing); rectum: 77.0492% (minimum 97%, Missing); retina: 86.2385% (minimum 99%, Missing); salivary gland: 87.8505% (minimum 97%, Missing); skeletal muscle: 87.0370% (minimum 99%, Missing); skin: 81.7391% (minimum 95%, Missing); small intestine: 84.6847% (minimum 99%, Missing); smooth muscle: 81.0345% (minimum 99%, Missing); spinal cord: 87.8505% (minimum 99%, Missing); spleen: 81.7391% (minimum 95%, Uncertain); stomach: 81.7391% (minimum 97%, Missing); thymus: 52.5140% (minimum 95%, Missing); thyroid gland: 85.4545% (minimum 95%, Missing); tongue: 81.7391% (minimum 97%, Missing); urinary bladder: 83.9286% (minimum 97%, Missing)",0,2,partial,9.3,6.3,8.5,"bone marrow: 9.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 2); rectum: 2.8 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); duodenum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000120334,CENPL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.42486,-0.371274,-0.487326
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,40,9,6.1,"liver: 40 nTPM (vital, limit 6); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120341,SEC16B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.4118% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.7647% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.3043% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.3043% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.6744% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.6250% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.7778% (minimum 99%, Baseline (adaptation disabled)); colon: 51.2195% (minimum 97%, Baseline (adaptation disabled)); duodenum: 12.8049% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.3617% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.3043% (minimum 99%, Baseline (adaptation disabled)); kidney: 52.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 9.5023% (minimum 99%, Baseline (adaptation disabled)); lung: 61.7647% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.7778% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.3043% (minimum 99%, Baseline (adaptation disabled)); pancreas: 29.5775% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.5000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 49.4118% (minimum 97%, Baseline (adaptation disabled)); retina: 39.2523% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 54.5455% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 31.5789% (minimum 99%, Baseline (adaptation disabled)); skin: 59.1549% (minimum 95%, Baseline (adaptation disabled)); small intestine: 12.8834% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 40.7767% (minimum 95%, Baseline (adaptation disabled)); stomach: 31.8182% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.3043% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 56.7568% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.4138% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,40,9,6.1,"liver: 40 nTPM (vital, limit 1); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9 nTPM (protected, limit 2); retina: 6.5 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); rectum: 4.3 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); smooth muscle: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120341,SEC16B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.542233,-0.651818,-0.894977
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.4118% (minimum 60%, Enhanced); adrenal gland: 61.7647% (minimum 95%, Enhanced); amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 91.3043% (minimum 99%, Missing); bone marrow: 93.3333% (minimum 99%, Missing); cerebral cortex: 65.6250% (minimum 95%, Enhanced); choroid plexus: 77.7778% (minimum 99%, Missing); colon: 51.2195% (minimum 97%, Missing); duodenum: 12.8049% (minimum 99%, Missing); esophagus: 66.6667% (minimum 80%, Enhanced); heart muscle: 60.0000% (minimum 95%, Enhanced); hippocampal formation: 89.3617% (minimum 99%, Missing); hypothalamus: 91.3043% (minimum 99%, Missing); kidney: 52.5000% (minimum 95%, Enhanced); liver: 9.5023% (minimum 95%, Enhanced); lung: 61.7647% (minimum 95%, Enhanced); lymph node: 77.7778% (minimum 80%, Enhanced); midbrain: 91.3043% (minimum 99%, Missing); pancreas: 29.5775% (minimum 99%, Missing); pituitary gland: 75.0000% (minimum 99%, Missing); rectum: 49.4118% (minimum 97%, Missing); retina: 39.2523% (minimum 99%, Missing); salivary gland: 54.5455% (minimum 80%, Enhanced); skeletal muscle: 31.5789% (minimum 95%, Enhanced); skin: 59.1549% (minimum 60%, Enhanced); small intestine: 12.8834% (minimum 99%, Missing); smooth muscle: 58.3333% (minimum 95%, Enhanced); spinal cord: 93.3333% (minimum 99%, Missing); spleen: 40.7767% (minimum 60%, Enhanced); stomach: 31.8182% (minimum 80%, Enhanced); thymus: 91.3043% (minimum 95%, Missing); tongue: 56.7568% (minimum 97%, Missing); urinary bladder: 72.4138% (minimum 80%, Enhanced)",0,7,partial,40,9,6.1,"liver: 40 nTPM (vital, limit 6); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); colon: 4 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120341,SEC16B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.192233,-0.481818,-0.861951
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.2,1.4,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000120436,GPR31,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 87.5000% (minimum 99%, Baseline (adaptation disabled)); duodenum: 77.7778% (minimum 99%, Baseline (adaptation disabled)); lymph node: 33.3333% (minimum 97%, Baseline (adaptation disabled)); small intestine: 87.5000% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.8462% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.5000% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,1.4,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000120436,GPR31,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.411538,-0.636667,-0.212222
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 87.5000% (minimum 99%, Missing); duodenum: 77.7778% (minimum 99%, Missing); lymph node: 33.3333% (minimum 97%, Missing); small intestine: 87.5000% (minimum 99%, Missing); spleen: 53.8462% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thymus: 70.0000% (minimum 95%, Missing)",0,80,unavailable,0.2,1.4,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000120436,GPR31,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.411538,-0.636667,-0.212222
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,0.4,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000120440,TTLL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 91.7949% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.3516% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8950% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.6,0.4,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000120440,TTLL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0335165,0.00814208,-0.0720513
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 91.7949% (minimum 99%, Missing); small intestine: 98.3516% (minimum 99%, Missing); spinal cord: 98.8950% (minimum 99%, Missing)",0,80,unavailable,1.6,0.4,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000120440,TTLL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0335165,0.00814208,-0.0720513
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,24.4,21.5,20.9,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 2); thyroid gland: 20.9 nTPM (manageable, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); salivary gland: 18.9 nTPM (protected, limit 2); pancreas: 18.9 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 2); stomach: 18.4 nTPM (protected, limit 2); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 2); adipose tissue: 15.4 nTPM (manageable, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); esophagus: 14.3 nTPM (protected, limit 2); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 2); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); skin: 12.5 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 2); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000120451,SNX19,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.3407% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 53.6269% (minimum 99%, Baseline (adaptation disabled)); amygdala: 54.7619% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 52.4051% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 70.6485% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.5263% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.4033% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.8689% (minimum 99%, Baseline (adaptation disabled)); colon: 49.0521% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.4860% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.1429% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.4925% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.4737% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.0532% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.2500% (minimum 99%, Baseline (adaptation disabled)); liver: 52.4051% (minimum 99%, Baseline (adaptation disabled)); lung: 59.3123% (minimum 99%, Baseline (adaptation disabled)); lymph node: 65.9236% (minimum 97%, Baseline (adaptation disabled)); midbrain: 50.6112% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.2727% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.1823% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.3476% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.3499% (minimum 97%, Baseline (adaptation disabled)); retina: 57.9832% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 52.2727% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 47.3684% (minimum 99%, Baseline (adaptation disabled)); skin: 62.3494% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.9832% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 52.4051% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 45.8980% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.1461% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.9412% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.7143% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 49.7596% (minimum 95%, Baseline (adaptation disabled)); tongue: 61.9760% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.8061% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,24.4,21.5,20.9,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 2); thyroid gland: 20.9 nTPM (manageable, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); salivary gland: 18.9 nTPM (protected, limit 2); pancreas: 18.9 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 2); stomach: 18.4 nTPM (protected, limit 2); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 2); adipose tissue: 15.4 nTPM (manageable, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); esophagus: 14.3 nTPM (protected, limit 2); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 2); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); skin: 12.5 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 2); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000120451,SNX19,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.452404,-0.479479,-0.53102
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.3407% (minimum 95%, Uncertain); adrenal gland: 53.6269% (minimum 99%, Missing); amygdala: 54.7619% (minimum 99%, Missing); basal ganglia: 52.4051% (minimum 99%, Missing); bone marrow: 70.6485% (minimum 99%, Uncertain); cerebellum: 60.5263% (minimum 99%, Missing); cerebral cortex: 56.4033% (minimum 99%, Missing); choroid plexus: 67.8689% (minimum 99%, Missing); colon: 49.0521% (minimum 97%, Missing); duodenum: 64.4860% (minimum 99%, Missing); esophagus: 59.1429% (minimum 97%, Uncertain); heart muscle: 51.4925% (minimum 99%, Missing); hippocampal formation: 54.4737% (minimum 99%, Missing); hypothalamus: 55.0532% (minimum 99%, Missing); kidney: 56.2500% (minimum 99%, Missing); liver: 52.4051% (minimum 99%, Missing); lung: 59.3123% (minimum 99%, Missing); lymph node: 65.9236% (minimum 97%, Uncertain); midbrain: 50.6112% (minimum 99%, Missing); pancreas: 52.2727% (minimum 99%, Missing); parathyroid gland: 57.1823% (minimum 97%, Missing); pituitary gland: 55.3476% (minimum 99%, Missing); rectum: 60.3499% (minimum 97%, Uncertain); retina: 57.9832% (minimum 99%, Missing); salivary gland: 52.2727% (minimum 97%, Uncertain); skeletal muscle: 47.3684% (minimum 99%, Missing); skin: 62.3494% (minimum 95%, Missing); small intestine: 57.9832% (minimum 99%, Missing); smooth muscle: 52.4051% (minimum 99%, Uncertain); spinal cord: 45.8980% (minimum 99%, Missing); spleen: 58.1461% (minimum 95%, Uncertain); stomach: 52.9412% (minimum 97%, Missing); thymus: 65.7143% (minimum 95%, Missing); thyroid gland: 49.7596% (minimum 95%, Missing); tongue: 61.9760% (minimum 97%, Missing); urinary bladder: 52.8061% (minimum 97%, Missing)",0,6,partial,24.4,21.5,20.9,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 2); thyroid gland: 20.9 nTPM (manageable, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); salivary gland: 18.9 nTPM (protected, limit 2); pancreas: 18.9 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 2); stomach: 18.4 nTPM (protected, limit 2); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 2); adipose tissue: 15.4 nTPM (manageable, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); esophagus: 14.3 nTPM (protected, limit 2); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 2); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); skin: 12.5 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 2); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000120451,SNX19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.452404,-0.479479,-0.53102
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,57,1.5,0.9,"pancreas: 57 nTPM (vital, limit 2); choroid plexus: 13.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus; tonsil,ENSG00000120498,TEX11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.3815% (minimum 99%, Baseline (adaptation disabled)); colon: 88.9764% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.2609% (minimum 99%, Baseline (adaptation disabled)); pancreas: 16.5447% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.2812% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.2609% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.6230% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.5812% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.7627% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,57,1.5,0.9,"pancreas: 57 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus; tonsil,ENSG00000120498,TEX11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0237705,-0.0871875,-0.824553
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.3815% (minimum 99%, Missing); colon: 88.9764% (minimum 95%, Approved); pancreas: 16.5447% (minimum 98%, Approved); rectum: 88.2812% (minimum 95%, Approved)",0,1,partial,57,1.5,0.9,"pancreas: 57 nTPM (vital, limit 2); choroid plexus: 13.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus; tonsil,ENSG00000120498,TEX11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0262295,-0.0671875,-0.814553
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7,9.6,6.7,"stomach: 9.6 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); colon: 6.7 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 2); lymph node: 5.4 nTPM (protected, limit 2); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); urinary bladder: 4.5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); pituitary gland: 3.5 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120519,SLC10A7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.1860% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.0061% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.8613% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.8613% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.8539% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.8613% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.6389% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.1481% (minimum 99%, Baseline (adaptation disabled)); colon: 63.9785% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.5610% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.9524% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.2319% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.2319% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.7742% (minimum 99%, Baseline (adaptation disabled)); liver: 62.9630% (minimum 99%, Baseline (adaptation disabled)); lung: 67.6136% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.7861% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.8028% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.3846% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 76.7742% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.2727% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.2115% (minimum 97%, Baseline (adaptation disabled)); retina: 75.7962% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.3243% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.3972% (minimum 99%, Baseline (adaptation disabled)); skin: 76.7742% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.1860% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.9524% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.5906% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.3488% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.3846% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 63.9785% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.3333% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.5610% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7,9.6,6.7,"stomach: 9.6 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); colon: 6.7 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 2); lymph node: 5.4 nTPM (protected, limit 2); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); urinary bladder: 4.5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); pituitary gland: 3.5 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120519,SLC10A7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.310215,-0.416512,-0.36037
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.1860% (minimum 95%, Missing); adrenal gland: 73.0061% (minimum 99%, Missing); amygdala: 86.8613% (minimum 99%, Missing); basal ganglia: 86.8613% (minimum 99%, Missing); bone marrow: 66.8539% (minimum 99%, Missing); cerebellum: 86.8613% (minimum 99%, Missing); cerebral cortex: 82.6389% (minimum 99%, Missing); choroid plexus: 88.1481% (minimum 99%, Missing); colon: 63.9785% (minimum 97%, Missing); duodenum: 72.5610% (minimum 99%, Missing); esophagus: 68.0000% (minimum 97%, Missing); heart muscle: 80.9524% (minimum 99%, Missing); hippocampal formation: 86.2319% (minimum 99%, Missing); hypothalamus: 86.2319% (minimum 99%, Missing); kidney: 76.7742% (minimum 99%, Missing); liver: 62.9630% (minimum 99%, Missing); lung: 67.6136% (minimum 99%, Missing); lymph node: 68.7861% (minimum 97%, Missing); midbrain: 83.8028% (minimum 99%, Missing); pancreas: 65.3846% (minimum 99%, Missing); parathyroid gland: 76.7742% (minimum 97%, Missing); pituitary gland: 77.2727% (minimum 99%, Missing); rectum: 57.2115% (minimum 97%, Missing); retina: 75.7962% (minimum 99%, Missing); salivary gland: 64.3243% (minimum 97%, Missing); skeletal muscle: 84.3972% (minimum 99%, Missing); skin: 76.7742% (minimum 95%, Missing); small intestine: 69.1860% (minimum 99%, Missing); smooth muscle: 68.0000% (minimum 99%, Missing); spinal cord: 80.9524% (minimum 99%, Missing); spleen: 69.5906% (minimum 95%, Missing); stomach: 55.3488% (minimum 97%, Missing); thymus: 65.3846% (minimum 95%, Missing); thyroid gland: 63.9785% (minimum 95%, Missing); tongue: 79.3333% (minimum 97%, Missing); urinary bladder: 72.5610% (minimum 97%, Missing)",0,80,unavailable,7,9.6,6.7,"stomach: 9.6 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); colon: 6.7 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 2); lymph node: 5.4 nTPM (protected, limit 2); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); urinary bladder: 4.5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); pituitary gland: 3.5 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120519,SLC10A7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.310215,-0.416512,-0.36037
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000120563,LYZL1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000120563,LYZL1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00798793
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000120563,LYZL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00798793
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,147.7,22.5,31,"bone marrow: 147.7 nTPM (vital, limit 1); thymus: 31 nTPM (manageable, limit 5); tongue: 22.5 nTPM (protected, limit 2); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 2); retina: 18.7 nTPM (vital, limit 1); spleen: 18.1 nTPM (manageable, limit 5); thyroid gland: 16.3 nTPM (manageable, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 2); colon: 15.4 nTPM (protected, limit 2); urinary bladder: 14.7 nTPM (protected, limit 2); salivary gland: 14.6 nTPM (protected, limit 2); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); pancreas: 13.9 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); stomach: 13.6 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 2); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120616,EPC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.7101% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.8963% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.2807% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.7904% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 12.2400% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 49.0476% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.2119% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.5410% (minimum 99%, Baseline (adaptation disabled)); colon: 57.2222% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.9842% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.6051% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.1745% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.2803% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.7915% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.1745% (minimum 99%, Baseline (adaptation disabled)); liver: 60.5882% (minimum 99%, Baseline (adaptation disabled)); lung: 59.0258% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.5192% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.5714% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.7101% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.3660% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.1010% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.9061% (minimum 97%, Baseline (adaptation disabled)); retina: 52.4173% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.5227% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 48.4706% (minimum 99%, Baseline (adaptation disabled)); skin: 60.5882% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.0482% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.9783% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.7904% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.2300% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.2339% (minimum 97%, Baseline (adaptation disabled)); thymus: 39.9225% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.8266% (minimum 95%, Baseline (adaptation disabled)); tongue: 47.7958% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.3569% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,147.7,22.5,31,"bone marrow: 147.7 nTPM (vital, limit 1); thymus: 31 nTPM (manageable, limit 5); tongue: 22.5 nTPM (protected, limit 2); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 2); retina: 18.7 nTPM (vital, limit 1); spleen: 18.1 nTPM (manageable, limit 5); thyroid gland: 16.3 nTPM (manageable, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 2); colon: 15.4 nTPM (protected, limit 2); urinary bladder: 14.7 nTPM (protected, limit 2); salivary gland: 14.6 nTPM (protected, limit 2); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); pancreas: 13.9 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); stomach: 13.6 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 2); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120616,EPC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.550775,-0.492042,-0.8676
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.7101% (minimum 95%, Missing); adrenal gland: 68.8963% (minimum 99%, Missing); amygdala: 72.2807% (minimum 99%, Missing); basal ganglia: 70.7904% (minimum 99%, Missing); bone marrow: 12.2400% (minimum 99%, Missing); cerebellum: 49.0476% (minimum 99%, Missing); cerebral cortex: 68.2119% (minimum 99%, Missing); choroid plexus: 67.5410% (minimum 99%, Missing); colon: 57.2222% (minimum 97%, Missing); duodenum: 64.9842% (minimum 99%, Missing); esophagus: 65.6051% (minimum 97%, Missing); heart muscle: 64.1745% (minimum 99%, Missing); hippocampal formation: 71.2803% (minimum 99%, Missing); hypothalamus: 72.7915% (minimum 99%, Missing); kidney: 64.1745% (minimum 99%, Missing); liver: 60.5882% (minimum 99%, Missing); lung: 59.0258% (minimum 99%, Missing); lymph node: 49.5192% (minimum 97%, Missing); midbrain: 73.5714% (minimum 99%, Missing); pancreas: 59.7101% (minimum 99%, Missing); parathyroid gland: 59.3660% (minimum 97%, Missing); pituitary gland: 67.1010% (minimum 99%, Missing); rectum: 56.9061% (minimum 97%, Missing); retina: 52.4173% (minimum 99%, Missing); salivary gland: 58.5227% (minimum 97%, Missing); skeletal muscle: 48.4706% (minimum 99%, Missing); skin: 60.5882% (minimum 95%, Missing); small intestine: 62.0482% (minimum 99%, Missing); smooth muscle: 55.9783% (minimum 99%, Missing); spinal cord: 70.7904% (minimum 99%, Missing); spleen: 53.2300% (minimum 95%, Missing); stomach: 60.2339% (minimum 97%, Missing); thymus: 39.9225% (minimum 95%, Missing); thyroid gland: 55.8266% (minimum 95%, Missing); tongue: 47.7958% (minimum 97%, Missing); urinary bladder: 58.3569% (minimum 97%, Missing)",0,80,unavailable,147.7,22.5,31,"bone marrow: 147.7 nTPM (vital, limit 1); thymus: 31 nTPM (manageable, limit 5); tongue: 22.5 nTPM (protected, limit 2); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 2); retina: 18.7 nTPM (vital, limit 1); spleen: 18.1 nTPM (manageable, limit 5); thyroid gland: 16.3 nTPM (manageable, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 2); colon: 15.4 nTPM (protected, limit 2); urinary bladder: 14.7 nTPM (protected, limit 2); salivary gland: 14.6 nTPM (protected, limit 2); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); pancreas: 13.9 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); stomach: 13.6 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 2); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000120616,EPC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.550775,-0.492042,-0.8676
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,4,12,1.2,"lymph node: 12 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000120659,TNFSF11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.1034% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 93.1034% (minimum 99%, Baseline (adaptation disabled)); colon: 81.8182% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 40.2985% (minimum 99%, Baseline (adaptation disabled)); lung: 96.4286% (minimum 99%, Baseline (adaptation disabled)); lymph node: 18.3673% (minimum 97%, Baseline (adaptation disabled)); pancreas: 96.4286% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.3636% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 93.1034% (minimum 97%, Baseline (adaptation disabled)); small intestine: 62.7907% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.0968% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.3750% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.2308% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 77.1429% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,4,12,1.2,"lymph node: 12 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000120659,TNFSF11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.257692,-0.786327,-0.587015
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 93.1034% (minimum 99%, Missing); duodenum: 90.0000% (minimum 95%, Enhanced); liver: 40.2985% (minimum 95%, Enhanced); lymph node: 18.3673% (minimum 97%, Missing); rectum: 61.3636% (minimum 80%, Enhanced); small intestine: 62.7907% (minimum 95%, Enhanced); spleen: 87.0968% (minimum 95%, Missing); thymus: 69.2308% (minimum 95%, Missing); urinary bladder: 77.1429% (minimum 80%, Enhanced)",0,1,partial,4,12,1.2,"lymph node: 12 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000120659,TNFSF11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.257692,-0.786327,-0.547015
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.8,5.1,0.5,"tongue: 5.1 nTPM (protected, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000120669,SOHLH2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Wang 2016;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5240% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.0909% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.6842% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.0909% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.0432% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.7391% (minimum 99%, Baseline (adaptation disabled)); colon: 93.3566% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.8889% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.3899% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.6989% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.3571% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.4453% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.7391% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.0178% (minimum 97%, Baseline (adaptation disabled)); retina: 96.0432% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.8022% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.1618% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4453% (minimum 99%, Baseline (adaptation disabled)); tongue: 83.9623% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.7391% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.8,5.1,0.5,"tongue: 5.1 nTPM (protected, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000120669,SOHLH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Wang 2016;Loriot 2025,0.0316176,-0.130377,-0.0531579
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5240% (minimum 99%, Missing); amygdala: 97.0909% (minimum 99%, Missing); basal ganglia: 93.6842% (minimum 99%, Missing); bone marrow: 97.0909% (minimum 99%, Missing); cerebral cortex: 96.0432% (minimum 99%, Missing); choroid plexus: 96.7391% (minimum 99%, Missing); colon: 93.3566% (minimum 97%, Missing); duodenum: 98.8889% (minimum 99%, Missing); heart muscle: 96.3899% (minimum 99%, Missing); hippocampal formation: 95.6989% (minimum 99%, Missing); hypothalamus: 95.3571% (minimum 99%, Missing); kidney: 97.4453% (minimum 99%, Missing); midbrain: 96.7391% (minimum 99%, Missing); parathyroid gland: 95.0178% (minimum 97%, Missing); retina: 96.0432% (minimum 99%, Missing); skeletal muscle: 97.8022% (minimum 99%, Missing); smooth muscle: 98.1618% (minimum 99%, Missing); spinal cord: 97.4453% (minimum 99%, Missing); tongue: 83.9623% (minimum 97%, Missing); urinary bladder: 96.7391% (minimum 97%, Missing)",0,80,unavailable,1.8,5.1,0.5,"tongue: 5.1 nTPM (protected, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000120669,SOHLH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Wang 2016;Loriot 2025,0.0316176,-0.130377,-0.0531579
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000120952,PRAMEF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000120952,PRAMEF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000120952,PRAMEF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,83.6,66.6,41.8,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 2); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (manageable, limit 5); liver: 39.7 nTPM (vital, limit 1); salivary gland: 38.1 nTPM (protected, limit 2); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 2); esophagus: 19.2 nTPM (protected, limit 2); colon: 16 nTPM (protected, limit 2); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 2); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 2); skin: 8.1 nTPM (manageable, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 2); tongue: 7.9 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000121039,RDH10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.5729% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.3659% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.6337% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.8486% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.6230% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.1538% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.7321% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.3069% (minimum 99%, Baseline (adaptation disabled)); colon: 68.6275% (minimum 97%, Baseline (adaptation disabled)); duodenum: 52.6316% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.5756% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.7576% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.6736% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.0585% (minimum 99%, Baseline (adaptation disabled)); kidney: 45.3956% (minimum 99%, Baseline (adaptation disabled)); liver: 46.8541% (minimum 99%, Baseline (adaptation disabled)); lung: 72.6141% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.5864% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.2062% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.1696% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 81.2065% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.3770% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.4225% (minimum 97%, Baseline (adaptation disabled)); retina: 29.5110% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 47.8796% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.9329% (minimum 99%, Baseline (adaptation disabled)); skin: 81.2065% (minimum 95%, Baseline (adaptation disabled)); small intestine: 54.0123% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.9939% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.1612% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.3220% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.5746% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.7458% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.5851% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 34.4488% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,83.6,66.6,41.8,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 2); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (manageable, limit 5); liver: 39.7 nTPM (vital, limit 1); salivary gland: 38.1 nTPM (protected, limit 2); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 2); esophagus: 19.2 nTPM (protected, limit 2); colon: 16 nTPM (protected, limit 2); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 2); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 2); skin: 8.1 nTPM (manageable, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 2); tongue: 7.9 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000121039,RDH10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.494271,-0.625512,-0.69489
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.5729% (minimum 95%, Missing); adrenal gland: 85.3659% (minimum 99%, Missing); amygdala: 86.6337% (minimum 99%, Missing); basal ganglia: 86.8486% (minimum 99%, Missing); bone marrow: 91.6230% (minimum 99%, Missing); cerebellum: 96.1538% (minimum 99%, Missing); cerebral cortex: 83.7321% (minimum 99%, Missing); choroid plexus: 69.3069% (minimum 99%, Missing); colon: 68.6275% (minimum 97%, Missing); duodenum: 52.6316% (minimum 99%, Missing); esophagus: 64.5756% (minimum 97%, Missing); heart muscle: 75.7576% (minimum 99%, Missing); hippocampal formation: 90.6736% (minimum 99%, Missing); hypothalamus: 89.0585% (minimum 99%, Missing); kidney: 45.3956% (minimum 99%, Missing); liver: 46.8541% (minimum 99%, Missing); lung: 72.6141% (minimum 99%, Missing); lymph node: 76.5864% (minimum 97%, Missing); midbrain: 90.2062% (minimum 99%, Missing); pancreas: 51.1696% (minimum 99%, Missing); parathyroid gland: 81.2065% (minimum 97%, Missing); pituitary gland: 57.3770% (minimum 99%, Missing); rectum: 70.4225% (minimum 97%, Missing); retina: 29.5110% (minimum 99%, Missing); salivary gland: 47.8796% (minimum 97%, Missing); skeletal muscle: 83.9329% (minimum 99%, Missing); skin: 81.2065% (minimum 95%, Missing); small intestine: 54.0123% (minimum 99%, Missing); smooth muscle: 70.9939% (minimum 99%, Missing); spinal cord: 88.1612% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 59.3220% (minimum 97%, Missing); thymus: 85.5746% (minimum 95%, Missing); thyroid gland: 84.7458% (minimum 95%, Missing); tongue: 81.5851% (minimum 97%, Missing); urinary bladder: 34.4488% (minimum 97%, Missing)",0,80,unavailable,83.6,66.6,41.8,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 2); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (manageable, limit 5); liver: 39.7 nTPM (vital, limit 1); salivary gland: 38.1 nTPM (protected, limit 2); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 2); esophagus: 19.2 nTPM (protected, limit 2); colon: 16 nTPM (protected, limit 2); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 2); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 2); skin: 8.1 nTPM (manageable, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 2); tongue: 7.9 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000121039,RDH10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.494271,-0.625512,-0.69489
True,compatible,,True,True,False,,0,3,partial,1.7,0.1,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000121101,TEX14,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8679% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.8679% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.9068% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.0370% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8679% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8679% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.4962% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.8679% (minimum 99%, Baseline (adaptation disabled)); retina: 96.3235% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8679% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.7,0.1,0.2,"bone marrow: 1.7 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000121101,TEX14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0424242,0.0261977,-0.0509319
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.8679% (minimum 99%, Missing); basal ganglia: 98.8679% (minimum 99%, Missing); bone marrow: 93.9068% (minimum 95%, Enhanced); hippocampal formation: 98.8679% (minimum 99%, Missing); hypothalamus: 98.8679% (minimum 99%, Missing); midbrain: 98.8679% (minimum 99%, Missing); retina: 96.3235% (minimum 99%, Missing); spinal cord: 98.8679% (minimum 99%, Missing)",0,3,partial,1.7,0.1,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000121101,TEX14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.0267647
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,34.8,19.9,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 2); rectum: 9 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000121152,NCAPH,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5632% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5632% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.6382% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.8473% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7208% (minimum 99%, Baseline (adaptation disabled)); colon: 82.2542% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.3980% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.6914% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.8473% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5632% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8473% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8473% (minimum 99%, Baseline (adaptation disabled)); liver: 97.4432% (minimum 99%, Baseline (adaptation disabled)); lung: 96.8927% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.2841% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.2148% (minimum 97%, Baseline (adaptation disabled)); retina: 95.2778% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0784% (minimum 97%, Baseline (adaptation disabled)); skin: 88.1748% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.1117% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.7027% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4432% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.5013% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.7407% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.5149% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.2065% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,34.8,19.9,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 2); rectum: 9 nTPM (protected, limit 2); colon: 7.4 nTPM (protected, limit 2); esophagus: 6.2 nTPM (protected, limit 2); small intestine: 6 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000121152,NCAPH,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.464851,-0.337159,-0.493618
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.5632% (minimum 99%, Missing); basal ganglia: 98.5632% (minimum 99%, Missing); bone marrow: 49.6382% (minimum 99%, Missing); choroid plexus: 97.7208% (minimum 99%, Missing); duodenum: 86.3980% (minimum 95%, Enhanced); heart muscle: 98.8473% (minimum 99%, Missing); hippocampal formation: 98.5632% (minimum 99%, Missing); hypothalamus: 98.8473% (minimum 99%, Missing); lymph node: 63.2841% (minimum 97%, Missing); midbrain: 98.0000% (minimum 99%, Missing); rectum: 79.2148% (minimum 97%, Missing); retina: 95.2778% (minimum 99%, Missing); skin: 88.1748% (minimum 95%, Missing); small intestine: 85.1117% (minimum 95%, Enhanced); smooth muscle: 92.7027% (minimum 95%, Enhanced); spinal cord: 97.4432% (minimum 99%, Missing); spleen: 90.5013% (minimum 95%, Missing); stomach: 90.7407% (minimum 97%, Missing); thymus: 48.5149% (minimum 95%, Missing); urinary bladder: 93.2065% (minimum 97%, Missing)",0,5,partial,34.8,19.9,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 2); rectum: 9 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000121152,NCAPH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.464851,-0.337159,-0.493618
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,2.1,0.5,1.5,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000121207,LRAT,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 61.5385% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 42.1053% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.5385% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 97%, Baseline (adaptation disabled)); duodenum: 42.1053% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.1429% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 38.0952% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.8889% (minimum 99%, Baseline (adaptation disabled)); liver: 27.5862% (minimum 99%, Baseline (adaptation disabled)); lung: 72.7273% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8889% (minimum 97%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 50.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 47.0588% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.8889% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 72.7273% (minimum 95%, Baseline (adaptation disabled)); small intestine: 34.7826% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 32.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.8889% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.0000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 34.7826% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 88.8889% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.1,0.5,1.5,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000121207,LRAT,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.602174,-0.354615,-0.714138
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 80.0000% (minimum 99%, Missing); amygdala: 61.5385% (minimum 99%, Missing); basal ganglia: 42.1053% (minimum 99%, Missing); bone marrow: 61.5385% (minimum 99%, Missing); cerebellum: 88.8889% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 42.1053% (minimum 99%, Missing); heart muscle: 88.8889% (minimum 99%, Missing); hippocampal formation: 57.1429% (minimum 99%, Missing); hypothalamus: 38.0952% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 27.5862% (minimum 99%, Missing); lung: 72.7273% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 50.0000% (minimum 99%, Missing); parathyroid gland: 80.0000% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 47.0588% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); skeletal muscle: 50.0000% (minimum 99%, Missing); skin: 72.7273% (minimum 95%, Missing); small intestine: 34.7826% (minimum 99%, Missing); spinal cord: 32.0000% (minimum 99%, Missing); spleen: 88.8889% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thyroid gland: 34.7826% (minimum 95%, Missing); urinary bladder: 88.8889% (minimum 97%, Missing)",0,80,unavailable,2.1,0.5,1.5,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000121207,LRAT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.602174,-0.354615,-0.714138
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,13.1,11.7,26,"thymus: 26 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); thymus / cortical cells: High (Supported); thymus / medullary cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000121211,MND1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.8553% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.4785% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.4785% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.0351% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0892% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.6522% (minimum 99%, Baseline (adaptation disabled)); colon: 78.1726% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.1530% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.7957% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.0892% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.9024% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.2500% (minimum 99%, Baseline (adaptation disabled)); liver: 92.7711% (minimum 99%, Baseline (adaptation disabled)); lung: 95.6522% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.8266% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.7711% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0892% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.0892% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.8621% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 95.0617% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.7711% (minimum 99%, Baseline (adaptation disabled)); skin: 88.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.0335% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.1243% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.0585% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.1243% (minimum 97%, Baseline (adaptation disabled)); thymus: 37.1981% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.8553% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.2156% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,13.1,11.7,26,"thymus: 26 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 2); rectum: 4.9 nTPM (protected, limit 2); colon: 4.3 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); thymus / cortical cells: High (Supported); thymus / medullary cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000121211,MND1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.578019,-0.401734,-0.449649
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.8553% (minimum 97%, Supported); amygdala: 94.4785% (minimum 99%, Missing); basal ganglia: 94.4785% (minimum 99%, Missing); bone marrow: 54.0351% (minimum 99%, Missing); cerebral cortex: 95.6522% (minimum 97%, Supported); colon: 78.1726% (minimum 90%, Supported); duodenum: 84.1530% (minimum 97%, Supported); esophagus: 82.7957% (minimum 90%, Supported); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 93.9024% (minimum 99%, Missing); kidney: 96.2500% (minimum 97%, Supported); liver: 92.7711% (minimum 97%, Supported); lung: 95.6522% (minimum 99%, Missing); lymph node: 56.8266% (minimum 97%, Missing); midbrain: 92.7711% (minimum 99%, Missing); pituitary gland: 98.0892% (minimum 99%, Missing); rectum: 75.8621% (minimum 90%, Supported); skeletal muscle: 92.7711% (minimum 97%, Supported); small intestine: 86.0335% (minimum 97%, Supported); smooth muscle: 91.6667% (minimum 97%, Supported); spinal cord: 91.1243% (minimum 99%, Missing); spleen: 90.0585% (minimum 95%, Missing); thymus: 37.1981% (minimum 95%, Missing); tongue: 96.8553% (minimum 97%, Missing)",0,3,partial,13.1,11.7,26,"thymus: 26 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); thymus / cortical cells: High (Supported); thymus / medullary cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000121211,MND1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.578019,-0.401734,-0.449649
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,0,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000121270,ABCC11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 96.5885% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.6,0,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000121270,ABCC11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0434211,0.03,-0.0241151
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 96.5885% (minimum 99%, Missing)",0,80,unavailable,1.6,0,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000121270,ABCC11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0434211,0.03,-0.0241151
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,13.3,15,1.2,"rectum: 15 nTPM (protected, limit 12); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121380,BCL2L14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 74.5721% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.6347% (minimum 99%, Baseline (adaptation disabled)); liver: 98.3871% (minimum 99%, Baseline (adaptation disabled)); lung: 98.7055% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.9119% (minimum 97%, Baseline (adaptation disabled)); pancreas: 85.4342% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.0330% (minimum 97%, Baseline (adaptation disabled)); small intestine: 70.9302% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7055% (minimum 99%, Baseline (adaptation disabled)); stomach: 77.0202% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.6113% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,13.3,15,1.2,"rectum: 15 nTPM (protected, limit 2); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); stomach: 9.1 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121380,BCL2L14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0121451,-0.29967,-0.293653
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 74.5721% (minimum 80%, Enhanced); duodenum: 69.6347% (minimum 99%, Missing); lymph node: 95.9119% (minimum 97%, Missing); pancreas: 85.4342% (minimum 95%, Enhanced); rectum: 67.0330% (minimum 80%, Enhanced); small intestine: 70.9302% (minimum 99%, Missing); stomach: 77.0202% (minimum 80%, Enhanced)",0,4,partial,13.3,15,1.2,"rectum: 15 nTPM (protected, limit 12); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121380,BCL2L14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0121451,-0.12967,-0.293653
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,53.1,20.3,22.5,"bone marrow: 53.1 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); lymph node: 20.3 nTPM (protected, limit 2); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 2); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 2); colon: 14.4 nTPM (protected, limit 2); hippocampal formation: 14.3 nTPM (vital, limit 1); skin: 14 nTPM (manageable, limit 5); esophagus: 13.6 nTPM (protected, limit 2); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 2); midbrain: 11 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (manageable, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 2); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 2); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121390,PSPC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.6275% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.8537% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.8000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.2857% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 31.3953% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.2500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 55.2273% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 62.7907% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.7582% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.1161% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.4286% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 62.9534% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.6751% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.3130% (minimum 99%, Baseline (adaptation disabled)); liver: 73.8602% (minimum 99%, Baseline (adaptation disabled)); lung: 71.6814% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.4843% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.8385% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.3214% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 72.7545% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.6395% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.8321% (minimum 97%, Baseline (adaptation disabled)); retina: 58.9806% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.4706% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 54.6067% (minimum 99%, Baseline (adaptation disabled)); skin: 63.4465% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.9421% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.5753% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.8276% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.0341% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.5000% (minimum 97%, Baseline (adaptation disabled)); thymus: 51.9231% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 67.1271% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.3934% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.2273% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,53.1,20.3,22.5,"bone marrow: 53.1 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); lymph node: 20.3 nTPM (protected, limit 2); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 2); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 2); colon: 14.4 nTPM (protected, limit 2); hippocampal formation: 14.3 nTPM (vital, limit 1); skin: 14 nTPM (manageable, limit 5); esophagus: 13.6 nTPM (protected, limit 2); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 2); midbrain: 11 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (manageable, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 2); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 2); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121390,PSPC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.430769,-0.425157,-0.676047
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.6275% (minimum 95%, Missing); adrenal gland: 65.8537% (minimum 99%, Missing); amygdala: 64.8000% (minimum 99%, Missing); basal ganglia: 64.2857% (minimum 99%, Missing); bone marrow: 31.3953% (minimum 99%, Missing); cerebellum: 56.2500% (minimum 99%, Missing); cerebral cortex: 55.2273% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 62.7907% (minimum 97%, Missing); duodenum: 66.7582% (minimum 99%, Missing); esophagus: 64.1161% (minimum 97%, Missing); heart muscle: 69.4286% (minimum 99%, Missing); hippocampal formation: 62.9534% (minimum 99%, Missing); hypothalamus: 61.6751% (minimum 99%, Missing); kidney: 67.3130% (minimum 99%, Missing); liver: 73.8602% (minimum 99%, Missing); lung: 71.6814% (minimum 99%, Missing); lymph node: 54.4843% (minimum 97%, Missing); midbrain: 68.8385% (minimum 99%, Missing); pancreas: 72.3214% (minimum 99%, Missing); parathyroid gland: 72.7545% (minimum 97%, Missing); pituitary gland: 70.6395% (minimum 99%, Missing); rectum: 61.8321% (minimum 97%, Missing); retina: 58.9806% (minimum 99%, Missing); salivary gland: 71.4706% (minimum 97%, Missing); skeletal muscle: 54.6067% (minimum 99%, Missing); skin: 63.4465% (minimum 95%, Missing); small intestine: 66.9421% (minimum 99%, Missing); smooth muscle: 66.5753% (minimum 99%, Missing); spinal cord: 69.8276% (minimum 99%, Missing); spleen: 69.0341% (minimum 95%, Missing); stomach: 67.5000% (minimum 97%, Missing); thymus: 51.9231% (minimum 95%, Missing); thyroid gland: 67.1271% (minimum 95%, Missing); tongue: 66.3934% (minimum 97%, Missing); urinary bladder: 55.2273% (minimum 97%, Missing)",0,4,partial,53.1,20.3,22.5,"bone marrow: 53.1 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); lymph node: 20.3 nTPM (protected, limit 2); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 2); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 2); colon: 14.4 nTPM (protected, limit 2); hippocampal formation: 14.3 nTPM (vital, limit 1); skin: 14 nTPM (manageable, limit 5); esophagus: 13.6 nTPM (protected, limit 2); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 2); midbrain: 11 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (manageable, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 2); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 2); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121390,PSPC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.430769,-0.425157,-0.676047
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000121446,RGSL1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000121446,RGSL1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.01,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000121446,RGSL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.01,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,4.7,0.5,12.1,"thymus: 12.1 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000121570,DPPA4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 93.1818% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 46.5909% (minimum 99%, Baseline (adaptation disabled)); liver: 87.2340% (minimum 99%, Baseline (adaptation disabled)); lung: 93.1818% (minimum 99%, Baseline (adaptation disabled)); lymph node: 89.1304% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.2340% (minimum 99%, Baseline (adaptation disabled)); thymus: 25.3086% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,4.7,0.5,12.1,"thymus: 12.1 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000121570,DPPA4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.696914,-0.0786957,-0.524091
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 93.1818% (minimum 99%, Missing); bone marrow: 46.5909% (minimum 95%, Enhanced); liver: 87.2340% (minimum 95%, Enhanced); lung: 93.1818% (minimum 95%, Enhanced); pituitary gland: 87.2340% (minimum 99%, Missing); thymus: 25.3086% (minimum 95%, Missing)",0,2,partial,4.7,0.5,12.1,"thymus: 12.1 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000121570,DPPA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.696914,0.03,-0.484091
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,8.1,4.5,9.3,"thymus: 9.3 nTPM (manageable, limit 5); bone marrow: 8.1 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121621,KIF18A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.1495% (minimum 99%, Baseline (adaptation disabled)); colon: 89.8649% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.4762% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.0959% (minimum 97%, Baseline (adaptation disabled)); kidney: 97.7941% (minimum 99%, Baseline (adaptation disabled)); liver: 97.7941% (minimum 99%, Baseline (adaptation disabled)); lung: 93.0070% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.7191% (minimum 97%, Baseline (adaptation disabled)); rectum: 86.9281% (minimum 97%, Baseline (adaptation disabled)); retina: 95.6835% (minimum 99%, Baseline (adaptation disabled)); skin: 91.7241% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.0959% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5185% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.6835% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.8496% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.3611% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.0000% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,8.1,4.5,9.3,"thymus: 9.3 nTPM (manageable, limit 5); bone marrow: 8.1 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121621,KIF18A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.361504,-0.222809,-0.368505
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.1495% (minimum 99%, Missing); colon: 89.8649% (minimum 97%, Missing); duodenum: 90.4762% (minimum 99%, Missing); esophagus: 91.0959% (minimum 97%, Missing); kidney: 97.7941% (minimum 99%, Missing); liver: 97.7941% (minimum 99%, Missing); lung: 93.0070% (minimum 99%, Missing); lymph node: 74.7191% (minimum 97%, Missing); rectum: 86.9281% (minimum 97%, Missing); retina: 95.6835% (minimum 99%, Missing); skin: 91.7241% (minimum 95%, Missing); small intestine: 91.0959% (minimum 99%, Missing); smooth muscle: 95.0000% (minimum 99%, Missing); spinal cord: 98.5185% (minimum 99%, Missing); stomach: 95.6835% (minimum 97%, Missing); thymus: 58.8496% (minimum 95%, Missing); thyroid gland: 92.3611% (minimum 95%, Missing); urinary bladder: 95.0000% (minimum 97%, Missing)",0,4,partial,8.1,4.5,9.3,"thymus: 9.3 nTPM (manageable, limit 5); bone marrow: 8.1 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121621,KIF18A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.361504,-0.222809,-0.368505
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: Medium (Enhanced),59,not_established,not_triggered,,,ENSG00000121634,GJA8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"kidney: 98.2759% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: Medium (Enhanced),59,not_established,not_triggered,,,ENSG00000121634,GJA8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,-0.00724138
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: Medium (Enhanced),59,not_established,not_triggered,,,ENSG00000121634,GJA8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,71.8,5,5.8,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000121690,DEPDC7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.1631% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.9463% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.1973% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.1581% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9170% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.8814% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.7285% (minimum 99%, Baseline (adaptation disabled)); colon: 86.1635% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.4113% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.4353% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.4789% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.2508% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.8356% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.3074% (minimum 99%, Baseline (adaptation disabled)); liver: 27.6210% (minimum 99%, Baseline (adaptation disabled)); lung: 96.8198% (minimum 99%, Baseline (adaptation disabled)); midbrain: 90.7285% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.1029% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.5676% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.1631% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.5679% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 93.5154% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.3583% (minimum 99%, Baseline (adaptation disabled)); skin: 82.5301% (minimum 95%, Baseline (adaptation disabled)); small intestine: 49.2806% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.4828% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.8934% (minimum 99%, Baseline (adaptation disabled)); stomach: 90.4290% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.7285% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.8198% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.1404% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,71.8,5,5.8,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000121690,DEPDC7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.124699,-0.124321,-0.71379
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.1631% (minimum 99%, Missing); amygdala: 91.9463% (minimum 99%, Missing); basal ganglia: 93.1973% (minimum 99%, Missing); bone marrow: 94.1581% (minimum 99%, Missing); cerebellum: 98.9170% (minimum 99%, Missing); cerebral cortex: 92.8814% (minimum 99%, Missing); choroid plexus: 90.7285% (minimum 99%, Missing); colon: 86.1635% (minimum 97%, Missing); duodenum: 53.4113% (minimum 99%, Missing); esophagus: 86.4353% (minimum 97%, Missing); heart muscle: 96.4789% (minimum 99%, Missing); hippocampal formation: 89.2508% (minimum 99%, Missing); hypothalamus: 93.8356% (minimum 99%, Missing); kidney: 59.3074% (minimum 99%, Missing); liver: 27.6210% (minimum 99%, Missing); lung: 96.8198% (minimum 99%, Missing); midbrain: 90.7285% (minimum 99%, Missing); pancreas: 88.1029% (minimum 99%, Missing); parathyroid gland: 92.5676% (minimum 97%, Missing); pituitary gland: 97.1631% (minimum 99%, Missing); rectum: 84.5679% (minimum 97%, Missing); salivary gland: 93.5154% (minimum 97%, Missing); skeletal muscle: 85.3583% (minimum 99%, Missing); skin: 82.5301% (minimum 95%, Missing); small intestine: 49.2806% (minimum 99%, Missing); smooth muscle: 94.4828% (minimum 99%, Missing); spinal cord: 85.8934% (minimum 99%, Missing); stomach: 90.4290% (minimum 97%, Missing); thymus: 90.7285% (minimum 95%, Missing); tongue: 96.8198% (minimum 97%, Missing); urinary bladder: 96.1404% (minimum 97%, Missing)",0,80,unavailable,71.8,5,5.8,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000121690,DEPDC7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.124699,-0.124321,-0.71379
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,2.5,2.5,1.2,"duodenum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121903,ZSCAN20,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.3704% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.1667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.4762% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.8571% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.8571% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.5172% (minimum 99%, Baseline (adaptation disabled)); colon: 65.5172% (minimum 97%, Baseline (adaptation disabled)); duodenum: 43.1818% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.3704% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.3514% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.1667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.1667% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.5172% (minimum 99%, Baseline (adaptation disabled)); liver: 79.1667% (minimum 99%, Baseline (adaptation disabled)); lung: 67.8571% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.3704% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 43.1818% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.8571% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.2903% (minimum 97%, Baseline (adaptation disabled)); retina: 54.2857% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 67.8571% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 70.3704% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.2903% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.5758% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.8571% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.2903% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.2903% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.2903% (minimum 95%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.8571% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,2.5,2.5,1.2,"duodenum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121903,ZSCAN20,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.337097,-0.538182,-0.558182
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Missing); adrenal gland: 70.3704% (minimum 99%, Missing); amygdala: 79.1667% (minimum 99%, Missing); basal ganglia: 76.0000% (minimum 99%, Missing); bone marrow: 90.4762% (minimum 99%, Missing); cerebellum: 67.8571% (minimum 99%, Missing); cerebral cortex: 67.8571% (minimum 99%, Missing); choroid plexus: 65.5172% (minimum 99%, Missing); colon: 65.5172% (minimum 97%, Missing); duodenum: 43.1818% (minimum 99%, Missing); esophagus: 70.3704% (minimum 97%, Missing); heart muscle: 51.3514% (minimum 99%, Uncertain); hippocampal formation: 79.1667% (minimum 99%, Missing); hypothalamus: 79.1667% (minimum 99%, Missing); kidney: 65.5172% (minimum 99%, Missing); liver: 79.1667% (minimum 99%, Missing); lung: 67.8571% (minimum 99%, Missing); lymph node: 76.0000% (minimum 97%, Missing); midbrain: 76.0000% (minimum 99%, Missing); pancreas: 70.3704% (minimum 99%, Missing); parathyroid gland: 43.1818% (minimum 97%, Missing); pituitary gland: 67.8571% (minimum 99%, Missing); rectum: 61.2903% (minimum 97%, Missing); retina: 54.2857% (minimum 99%, Missing); salivary gland: 67.8571% (minimum 97%, Missing); skeletal muscle: 63.3333% (minimum 99%, Missing); skin: 70.3704% (minimum 95%, Missing); small intestine: 61.2903% (minimum 99%, Missing); smooth muscle: 57.5758% (minimum 99%, Missing); spinal cord: 76.0000% (minimum 99%, Missing); spleen: 67.8571% (minimum 95%, Missing); stomach: 61.2903% (minimum 97%, Missing); thymus: 61.2903% (minimum 95%, Missing); thyroid gland: 61.2903% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 67.8571% (minimum 97%, Missing)",0,1,partial,2.5,2.5,1.2,"duodenum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000121903,ZSCAN20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.337097,-0.538182,-0.558182
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,2.5,0.1,0.5,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,ENSG00000121904,CSMD2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 42.8571% (minimum 99%, Baseline (adaptation disabled)); amygdala: 15.7895% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 10.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 13.6364% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 11.5385% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 25.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 13.6364% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 11.1111% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 17.6471% (minimum 99%, Baseline (adaptation disabled)); pancreas: 18.7500% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 27.2727% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 30.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 37.5000% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.5,0.1,0.5,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,ENSG00000121904,CSMD2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.575,-0.22,-0.882857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 42.8571% (minimum 99%, Missing); amygdala: 15.7895% (minimum 99%, Missing); basal ganglia: 10.7143% (minimum 99%, Missing); cerebellum: 13.6364% (minimum 99%, Missing); cerebral cortex: 11.5385% (minimum 99%, Missing); choroid plexus: 60.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 25.0000% (minimum 99%, Missing); esophagus: 75.0000% (minimum 97%, Missing); heart muscle: 60.0000% (minimum 99%, Missing); hippocampal formation: 13.6364% (minimum 99%, Missing); hypothalamus: 11.1111% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 17.6471% (minimum 99%, Missing); pancreas: 18.7500% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); retina: 27.2727% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); smooth muscle: 60.0000% (minimum 99%, Missing); spinal cord: 30.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); thyroid gland: 37.5000% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,80,unavailable,2.5,0.1,0.5,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,ENSG00000121904,CSMD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.575,-0.22,-0.882857
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.9,0.8,1,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000121988,ZRANB3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.4872% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.4545% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.8095% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.6098% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.7838% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.0930% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.9394% (minimum 99%, Baseline (adaptation disabled)); colon: 81.5789% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.1765% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.7838% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.5000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.6098% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.5789% (minimum 99%, Baseline (adaptation disabled)); liver: 75.6098% (minimum 99%, Baseline (adaptation disabled)); lung: 83.7838% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.1111% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.4872% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.0930% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.1111% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.4545% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.5714% (minimum 97%, Baseline (adaptation disabled)); retina: 70.4545% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.7838% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 81.5789% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.7838% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.6098% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.5789% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.7838% (minimum 97%, Baseline (adaptation disabled)); thymus: 81.5789% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.6098% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.7838% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 79.4872% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.9,0.8,1,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000121988,ZRANB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.193902,-0.175128,-0.37
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.4872% (minimum 95%, Missing); adrenal gland: 70.4545% (minimum 99%, Missing); amygdala: 77.5000% (minimum 99%, Missing); basal ganglia: 73.8095% (minimum 99%, Missing); bone marrow: 75.6098% (minimum 99%, Missing); cerebellum: 83.7838% (minimum 99%, Missing); cerebral cortex: 72.0930% (minimum 99%, Missing); choroid plexus: 93.9394% (minimum 99%, Missing); colon: 81.5789% (minimum 97%, Missing); duodenum: 91.1765% (minimum 99%, Missing); esophagus: 83.7838% (minimum 97%, Missing); heart muscle: 77.5000% (minimum 99%, Missing); hippocampal formation: 77.5000% (minimum 99%, Missing); hypothalamus: 75.6098% (minimum 99%, Missing); kidney: 81.5789% (minimum 99%, Missing); liver: 75.6098% (minimum 99%, Missing); lung: 83.7838% (minimum 99%, Missing); lymph node: 86.1111% (minimum 97%, Missing); midbrain: 79.4872% (minimum 99%, Missing); pancreas: 72.0930% (minimum 99%, Missing); parathyroid gland: 86.1111% (minimum 97%, Missing); pituitary gland: 70.4545% (minimum 99%, Missing); rectum: 88.5714% (minimum 97%, Missing); retina: 70.4545% (minimum 99%, Missing); salivary gland: 83.7838% (minimum 97%, Missing); skeletal muscle: 62.0000% (minimum 99%, Missing); skin: 81.5789% (minimum 95%, Missing); small intestine: 83.7838% (minimum 99%, Missing); smooth muscle: 88.5714% (minimum 99%, Missing); spinal cord: 75.6098% (minimum 99%, Missing); spleen: 81.5789% (minimum 95%, Missing); stomach: 83.7838% (minimum 97%, Missing); thymus: 81.5789% (minimum 95%, Missing); thyroid gland: 75.6098% (minimum 95%, Missing); tongue: 83.7838% (minimum 97%, Missing); urinary bladder: 79.4872% (minimum 97%, Missing)",0,80,unavailable,1.9,0.8,1,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000121988,ZRANB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.193902,-0.175128,-0.37
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0.2,4.6,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000122145,TBX22,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"thyroid gland: 70.1299% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0.2,4.6,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000122145,TBX22,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,-0.248701,0.0118182,0.01
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"thyroid gland: 70.1299% (minimum 95%, Missing)",0,80,unavailable,0,0.2,4.6,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000122145,TBX22,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,-0.248701,0.0118182,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,4.5,2,3.5,"pituitary gland: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000122304,PRM2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,4.5,2,3.5,"skeletal muscle: 4.5 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000122304,PRM2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0496923,0.0298242,0.00960443
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,4.5,2,3.5,"pituitary gland: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000122304,PRM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0499912,0.03,0.00985932
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,6.3,5.6,4.6,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 2); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122483,CCDC18,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 84.9462% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.7727% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.0476% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.8046% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.6338% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.8046% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.8605% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.7500% (minimum 99%, Baseline (adaptation disabled)); colon: 84.9462% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.7727% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.8132% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.7727% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.0476% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.0476% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.9412% (minimum 99%, Baseline (adaptation disabled)); liver: 84.0426% (minimum 99%, Baseline (adaptation disabled)); lung: 87.7778% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.5185% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.0476% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.1807% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.3415% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.8046% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.4433% (minimum 97%, Baseline (adaptation disabled)); retina: 96.3415% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.8605% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.6122% (minimum 99%, Baseline (adaptation disabled)); skin: 86.8132% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.0426% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.7727% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.9412% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.6990% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.8132% (minimum 97%, Baseline (adaptation disabled)); thymus: 63.2000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.8605% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.1807% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.7778% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,6.3,5.6,4.6,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 2); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122483,CCDC18,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.318,-0.384815,-0.433662
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 84.9462% (minimum 95%, Uncertain); adrenal gland: 89.7727% (minimum 99%, Missing); amygdala: 94.0476% (minimum 99%, Missing); basal ganglia: 90.8046% (minimum 99%, Missing); bone marrow: 55.6338% (minimum 99%, Missing); cerebellum: 90.8046% (minimum 99%, Missing); cerebral cortex: 91.8605% (minimum 99%, Missing); choroid plexus: 98.7500% (minimum 99%, Missing); colon: 84.9462% (minimum 97%, Missing); duodenum: 89.7727% (minimum 99%, Missing); esophagus: 86.8132% (minimum 97%, Missing); heart muscle: 89.7727% (minimum 99%, Missing); hippocampal formation: 94.0476% (minimum 99%, Missing); hypothalamus: 94.0476% (minimum 99%, Missing); kidney: 92.9412% (minimum 99%, Missing); liver: 84.0426% (minimum 99%, Missing); lung: 87.7778% (minimum 99%, Missing); lymph node: 58.5185% (minimum 97%, Missing); midbrain: 94.0476% (minimum 99%, Missing); pancreas: 95.1807% (minimum 99%, Missing); parathyroid gland: 96.3415% (minimum 97%, Missing); pituitary gland: 90.8046% (minimum 99%, Missing); rectum: 81.4433% (minimum 97%, Missing); retina: 96.3415% (minimum 99%, Missing); salivary gland: 91.8605% (minimum 97%, Uncertain); skeletal muscle: 80.6122% (minimum 99%, Missing); skin: 86.8132% (minimum 95%, Missing); small intestine: 84.0426% (minimum 99%, Missing); smooth muscle: 89.7727% (minimum 99%, Missing); spinal cord: 92.9412% (minimum 99%, Missing); spleen: 76.6990% (minimum 95%, Uncertain); stomach: 86.8132% (minimum 97%, Missing); thymus: 63.2000% (minimum 95%, Missing); thyroid gland: 91.8605% (minimum 95%, Missing); tongue: 95.1807% (minimum 97%, Missing); urinary bladder: 87.7778% (minimum 97%, Missing)",0,3,partial,6.3,5.6,4.6,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 2); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122483,CCDC18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.318,-0.384815,-0.433662
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,49,10.7,12.1,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); thymus: 12.1 nTPM (manageable, limit 5); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 2); skin: 10.5 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); liver: 10.1 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); thyroid gland: 9 nTPM (manageable, limit 5); esophagus: 8.8 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 2); salivary gland: 8.3 nTPM (protected, limit 2); lymph node: 8.2 nTPM (protected, limit 2); spleen: 7.8 nTPM (manageable, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 2); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122550,KLHL7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.6367% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.0878% (minimum 99%, Baseline (adaptation disabled)); amygdala: 74.0942% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.7715% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.0245% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.8267% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.7758% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.1564% (minimum 99%, Baseline (adaptation disabled)); colon: 82.2938% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.5041% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.2938% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 45.4950% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0459% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.2615% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.0534% (minimum 99%, Baseline (adaptation disabled)); liver: 80.1961% (minimum 99%, Baseline (adaptation disabled)); lung: 84.6791% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.2994% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.5612% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.3299% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.2636% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.2083% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.3299% (minimum 97%, Baseline (adaptation disabled)); retina: 73.6937% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.1301% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.4597% (minimum 99%, Baseline (adaptation disabled)); skin: 79.5720% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.9244% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.1961% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.0459% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.9836% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.8365% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.1698% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.9639% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.3121% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.7935% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,49,10.7,12.1,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); thymus: 12.1 nTPM (manageable, limit 5); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 2); skin: 10.5 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); liver: 10.1 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); thyroid gland: 9 nTPM (manageable, limit 5); esophagus: 8.8 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 2); salivary gland: 8.3 nTPM (protected, limit 2); lymph node: 8.2 nTPM (protected, limit 2); spleen: 7.8 nTPM (manageable, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 2); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122550,KLHL7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.178302,-0.177364,-0.53505
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.6367% (minimum 95%, Missing); adrenal gland: 69.0878% (minimum 99%, Missing); amygdala: 74.0942% (minimum 99%, Missing); basal ganglia: 74.7715% (minimum 99%, Missing); bone marrow: 77.0245% (minimum 99%, Uncertain); cerebellum: 73.8267% (minimum 99%, Missing); cerebral cortex: 72.7758% (minimum 99%, Missing); choroid plexus: 84.1564% (minimum 99%, Missing); colon: 82.2938% (minimum 97%, Missing); duodenum: 84.5041% (minimum 99%, Missing); esophagus: 82.2938% (minimum 97%, Missing); heart muscle: 45.4950% (minimum 99%, Missing); hippocampal formation: 75.0459% (minimum 99%, Missing); hypothalamus: 72.2615% (minimum 99%, Missing); kidney: 78.0534% (minimum 99%, Missing); liver: 80.1961% (minimum 99%, Missing); lung: 84.6791% (minimum 99%, Missing); lymph node: 83.2994% (minimum 97%, Missing); midbrain: 73.5612% (minimum 99%, Missing); pancreas: 84.3299% (minimum 99%, Missing); parathyroid gland: 79.2636% (minimum 97%, Missing); pituitary gland: 85.2083% (minimum 99%, Missing); rectum: 84.3299% (minimum 97%, Missing); retina: 73.6937% (minimum 99%, Missing); salivary gland: 83.1301% (minimum 97%, Missing); skeletal muscle: 82.4597% (minimum 99%, Missing); skin: 79.5720% (minimum 95%, Missing); small intestine: 85.9244% (minimum 99%, Missing); smooth muscle: 80.1961% (minimum 99%, Uncertain); spinal cord: 75.0459% (minimum 99%, Missing); spleen: 83.9836% (minimum 95%, Uncertain); stomach: 86.8365% (minimum 97%, Missing); thymus: 77.1698% (minimum 95%, Missing); thyroid gland: 81.9639% (minimum 95%, Missing); tongue: 81.3121% (minimum 97%, Missing); urinary bladder: 82.7935% (minimum 97%, Missing)",0,2,partial,49,10.7,12.1,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); thymus: 12.1 nTPM (manageable, limit 5); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 2); skin: 10.5 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); liver: 10.1 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); thyroid gland: 9 nTPM (manageable, limit 5); esophagus: 8.8 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 2); salivary gland: 8.3 nTPM (protected, limit 2); lymph node: 8.2 nTPM (protected, limit 2); spleen: 7.8 nTPM (manageable, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 2); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122550,KLHL7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.178302,-0.177364,-0.53505
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,24.2,14.6,14.4,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 2); adipose tissue: 14.4 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 2); spleen: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 2); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 2); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); thyroid gland: 6.4 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); hypothalamus: 4.4 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122591,HYCC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.8258% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.6614% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.1443% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.6614% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.2973% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.7020% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.0055% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.3371% (minimum 99%, Baseline (adaptation disabled)); colon: 60.3376% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.8511% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.7893% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.6066% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.7059% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.4706% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.0638% (minimum 99%, Baseline (adaptation disabled)); liver: 63.2743% (minimum 99%, Baseline (adaptation disabled)); lung: 51.8116% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.0784% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.4433% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 74.8691% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.2973% (minimum 97%, Baseline (adaptation disabled)); retina: 75.2632% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.4211% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 37.1429% (minimum 99%, Baseline (adaptation disabled)); skin: 74.8691% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.0952% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.0784% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.5888% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.4264% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.4706% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.7174% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 69.0821% (minimum 95%, Baseline (adaptation disabled)); tongue: 49.4810% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.3734% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,24.2,14.6,14.4,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 2); adipose tissue: 14.4 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 2); spleen: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 2); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 2); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); thyroid gland: 6.4 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); hypothalamus: 4.4 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122591,HYCC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.451742,-0.47519,-0.618571
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.8258% (minimum 95%, Missing); adrenal gland: 75.6614% (minimum 99%, Missing); amygdala: 71.1443% (minimum 99%, Missing); basal ganglia: 75.6614% (minimum 99%, Missing); bone marrow: 77.2973% (minimum 99%, Missing); cerebellum: 94.7020% (minimum 99%, Missing); cerebral cortex: 79.0055% (minimum 99%, Missing); choroid plexus: 80.3371% (minimum 99%, Missing); colon: 60.3376% (minimum 97%, Missing); duodenum: 60.8511% (minimum 99%, Missing); esophagus: 54.7893% (minimum 97%, Missing); heart muscle: 58.6066% (minimum 99%, Missing); hippocampal formation: 64.7059% (minimum 99%, Missing); hypothalamus: 76.4706% (minimum 99%, Missing); kidney: 76.0638% (minimum 99%, Missing); liver: 63.2743% (minimum 99%, Missing); lung: 51.8116% (minimum 99%, Missing); lymph node: 56.0784% (minimum 97%, Missing); midbrain: 71.5000% (minimum 99%, Missing); pancreas: 70.4433% (minimum 99%, Missing); parathyroid gland: 86.6667% (minimum 97%, Missing); pituitary gland: 74.8691% (minimum 99%, Missing); rectum: 77.2973% (minimum 97%, Missing); retina: 75.2632% (minimum 99%, Missing); salivary gland: 68.4211% (minimum 97%, Missing); skeletal muscle: 37.1429% (minimum 99%, Missing); skin: 74.8691% (minimum 95%, Missing); small intestine: 68.0952% (minimum 99%, Missing); smooth muscle: 56.0784% (minimum 99%, Missing); spinal cord: 72.5888% (minimum 99%, Missing); spleen: 55.4264% (minimum 95%, Missing); stomach: 76.4706% (minimum 97%, Missing); thymus: 77.7174% (minimum 95%, Missing); thyroid gland: 69.0821% (minimum 95%, Missing); tongue: 49.4810% (minimum 97%, Missing); urinary bladder: 61.3734% (minimum 97%, Missing)",0,6,partial,24.2,14.6,14.4,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 2); adipose tissue: 14.4 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 2); spleen: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 2); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 2); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); thyroid gland: 6.4 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); hypothalamus: 4.4 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122591,HYCC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.451742,-0.47519,-0.618571
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,0,0,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000122728,TAF1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.6,0,0,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000122728,TAF1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.49
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 99%, Missing)",0,80,unavailable,1.6,0,0,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000122728,TAF1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.49
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,6.2,2.4,2.3,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122778,KIAA1549,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.8305% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.7143% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.6111% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.6429% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.8305% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 55.7895% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 86.8852% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.3793% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.8125% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.6027% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.6027% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.2418% (minimum 99%, Baseline (adaptation disabled)); liver: 92.9825% (minimum 99%, Baseline (adaptation disabled)); lung: 74.6479% (minimum 99%, Baseline (adaptation disabled)); midbrain: 80.3030% (minimum 99%, Baseline (adaptation disabled)); pancreas: 46.0870% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.8312% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.7143% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 48.6239% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.7368% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.3793% (minimum 99%, Baseline (adaptation disabled)); skin: 86.8852% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.5385% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.4839% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.6429% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.3030% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.7368% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.8852% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.8125% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,6.2,2.4,2.3,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122778,KIAA1549,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.252632,-0.281688,-0.52913
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.8305% (minimum 95%, Missing); adrenal gland: 75.7143% (minimum 99%, Missing); amygdala: 75.7143% (minimum 99%, Missing); basal ganglia: 73.6111% (minimum 99%, Missing); bone marrow: 94.6429% (minimum 99%, Missing); cerebellum: 89.8305% (minimum 99%, Missing); cerebral cortex: 55.7895% (minimum 99%, Missing); choroid plexus: 88.3333% (minimum 99%, Missing); colon: 86.8852% (minimum 97%, Missing); duodenum: 88.3333% (minimum 99%, Missing); esophagus: 91.3793% (minimum 97%, Missing); heart muscle: 82.8125% (minimum 99%, Missing); hippocampal formation: 72.6027% (minimum 99%, Missing); hypothalamus: 72.6027% (minimum 99%, Missing); kidney: 58.2418% (minimum 99%, Missing); liver: 92.9825% (minimum 99%, Missing); lung: 74.6479% (minimum 99%, Missing); midbrain: 80.3030% (minimum 99%, Missing); pancreas: 46.0870% (minimum 99%, Missing); parathyroid gland: 68.8312% (minimum 97%, Missing); pituitary gland: 75.7143% (minimum 99%, Missing); rectum: 88.3333% (minimum 97%, Missing); retina: 48.6239% (minimum 99%, Missing); salivary gland: 69.7368% (minimum 97%, Missing); skeletal muscle: 91.3793% (minimum 99%, Missing); skin: 86.8852% (minimum 95%, Missing); small intestine: 88.3333% (minimum 99%, Missing); smooth muscle: 81.5385% (minimum 99%, Missing); spinal cord: 85.4839% (minimum 99%, Missing); spleen: 94.6429% (minimum 95%, Missing); stomach: 80.3030% (minimum 97%, Missing); thymus: 69.7368% (minimum 95%, Missing); thyroid gland: 88.3333% (minimum 95%, Missing); tongue: 86.8852% (minimum 97%, Missing); urinary bladder: 82.8125% (minimum 97%, Missing)",0,3,partial,6.2,2.4,2.3,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000122778,KIAA1549,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.252632,-0.281688,-0.52913
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000123165,ACTRT1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000123165,ACTRT1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000123165,ACTRT1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000123171,CCDC70,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000123171,CCDC70,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000123171,CCDC70,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,24.6,14.4,21.7,"bone marrow: 24.6 nTPM (vital, limit 1); thymus: 21.7 nTPM (manageable, limit 5); lymph node: 14.4 nTPM (protected, limit 2); rectum: 11.5 nTPM (protected, limit 2); colon: 8.7 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123219,CENPK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3077% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.2857% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.0588% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.6522% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 34.9206% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.0588% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.9577% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7778% (minimum 99%, Baseline (adaptation disabled)); colon: 60.2740% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.9718% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.5882% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.3504% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.3504% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.0588% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.2857% (minimum 99%, Baseline (adaptation disabled)); liver: 88.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 86.8421% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.8261% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.3504% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.6522% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.9577% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.7778% (minimum 99%, Baseline (adaptation disabled)); rectum: 53.4413% (minimum 97%, Baseline (adaptation disabled)); retina: 94.9640% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.0345% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.0588% (minimum 99%, Baseline (adaptation disabled)); skin: 60.8295% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.1111% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.6522% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.9677% (minimum 97%, Baseline (adaptation disabled)); thymus: 37.8223% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.3504% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.5443% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,24.6,14.4,21.7,"bone marrow: 24.6 nTPM (vital, limit 1); thymus: 21.7 nTPM (manageable, limit 5); lymph node: 14.4 nTPM (protected, limit 2); rectum: 11.5 nTPM (protected, limit 2); colon: 8.7 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123219,CENPK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.571777,-0.491739,-0.640794
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3077% (minimum 95%, Missing); adrenal gland: 94.2857% (minimum 99%, Missing); amygdala: 97.0588% (minimum 99%, Missing); basal ganglia: 95.6522% (minimum 99%, Missing); bone marrow: 34.9206% (minimum 99%, Missing); cerebellum: 97.0588% (minimum 99%, Missing); cerebral cortex: 92.9577% (minimum 99%, Missing); choroid plexus: 97.7778% (minimum 99%, Missing); colon: 60.2740% (minimum 97%, Missing); duodenum: 61.9718% (minimum 99%, Missing); esophagus: 70.5882% (minimum 97%, Missing); heart muscle: 96.3504% (minimum 99%, Missing); hippocampal formation: 96.3504% (minimum 99%, Missing); hypothalamus: 97.0588% (minimum 99%, Missing); kidney: 94.2857% (minimum 99%, Missing); liver: 88.0000% (minimum 99%, Missing); lung: 86.8421% (minimum 99%, Missing); lymph node: 47.8261% (minimum 97%, Missing); midbrain: 96.3504% (minimum 99%, Missing); pancreas: 95.6522% (minimum 99%, Missing); parathyroid gland: 92.9577% (minimum 97%, Missing); pituitary gland: 97.7778% (minimum 99%, Missing); rectum: 53.4413% (minimum 97%, Missing); retina: 94.9640% (minimum 99%, Missing); salivary gland: 91.0345% (minimum 97%, Missing); skeletal muscle: 97.0588% (minimum 99%, Missing); skin: 60.8295% (minimum 95%, Missing); small intestine: 61.1111% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spinal cord: 95.6522% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 70.9677% (minimum 97%, Missing); thymus: 37.8223% (minimum 95%, Missing); thyroid gland: 91.6667% (minimum 95%, Missing); tongue: 96.3504% (minimum 97%, Missing); urinary bladder: 83.5443% (minimum 97%, Missing)",0,80,unavailable,24.6,14.4,21.7,"bone marrow: 24.6 nTPM (vital, limit 1); thymus: 21.7 nTPM (manageable, limit 5); lymph node: 14.4 nTPM (protected, limit 2); rectum: 11.5 nTPM (protected, limit 2); colon: 8.7 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); stomach: 5.4 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123219,CENPK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.571777,-0.491739,-0.640794
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.8,5.3,8.6,"bone marrow: 8.8 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); rectum: 5.3 nTPM (protected, limit 2); lymph node: 4.3 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123473,STIL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.3636% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.9355% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.9355% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.4762% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 39.3103% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.9355% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.0625% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.4426% (minimum 99%, Baseline (adaptation disabled)); colon: 61.2903% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.6747% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.3704% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.4762% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.9355% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.4426% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.0625% (minimum 99%, Baseline (adaptation disabled)); liver: 87.6923% (minimum 99%, Baseline (adaptation disabled)); lung: 87.6923% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.9355% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.4762% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.6923% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.8182% (minimum 97%, Baseline (adaptation disabled)); retina: 85.0746% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.0270% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 67.0588% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.2500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.4286% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.9355% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.2817% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 39.8601% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.6923% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.4426% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.0746% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.8,5.3,8.6,"bone marrow: 8.8 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); rectum: 5.3 nTPM (protected, limit 2); lymph node: 4.3 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123473,STIL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.551399,-0.451818,-0.596897
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.3636% (minimum 95%, Missing); adrenal gland: 91.9355% (minimum 99%, Missing); amygdala: 91.9355% (minimum 99%, Missing); basal ganglia: 90.4762% (minimum 99%, Missing); bone marrow: 39.3103% (minimum 99%, Missing); cerebellum: 91.9355% (minimum 99%, Missing); cerebral cortex: 89.0625% (minimum 99%, Missing); choroid plexus: 93.4426% (minimum 99%, Missing); colon: 61.2903% (minimum 97%, Missing); duodenum: 68.6747% (minimum 99%, Missing); esophagus: 70.3704% (minimum 97%, Missing); heart muscle: 90.4762% (minimum 99%, Missing); hippocampal formation: 91.9355% (minimum 99%, Missing); hypothalamus: 93.4426% (minimum 99%, Missing); kidney: 89.0625% (minimum 99%, Missing); liver: 87.6923% (minimum 99%, Missing); lung: 87.6923% (minimum 99%, Missing); lymph node: 57.0000% (minimum 97%, Missing); midbrain: 91.9355% (minimum 99%, Missing); pancreas: 90.4762% (minimum 99%, Missing); parathyroid gland: 87.6923% (minimum 97%, Missing); pituitary gland: 95.0000% (minimum 99%, Missing); rectum: 51.8182% (minimum 97%, Missing); retina: 85.0746% (minimum 99%, Missing); salivary gland: 77.0270% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); skin: 67.0588% (minimum 95%, Missing); small intestine: 71.2500% (minimum 99%, Missing); smooth muscle: 81.4286% (minimum 99%, Missing); spinal cord: 91.9355% (minimum 99%, Missing); spleen: 80.2817% (minimum 95%, Missing); stomach: 76.0000% (minimum 97%, Missing); thymus: 39.8601% (minimum 95%, Missing); thyroid gland: 87.6923% (minimum 95%, Missing); tongue: 93.4426% (minimum 97%, Missing); urinary bladder: 85.0746% (minimum 97%, Missing)",0,80,unavailable,8.8,5.3,8.6,"bone marrow: 8.8 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); rectum: 5.3 nTPM (protected, limit 2); lymph node: 4.3 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123473,STIL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.551399,-0.451818,-0.596897
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,46.8,12.3,29.6,"bone marrow: 46.8 nTPM (vital, limit 1); thymus: 29.6 nTPM (manageable, limit 5); lymph node: 12.3 nTPM (protected, limit 2); esophagus: 5.4 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000123485,HJURP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 94.7368% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.5752% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 18.7500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.4286% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.2973% (minimum 99%, Baseline (adaptation disabled)); colon: 73.9726% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.4694% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.2973% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.4286% (minimum 99%, Baseline (adaptation disabled)); liver: 93.1034% (minimum 99%, Baseline (adaptation disabled)); lung: 89.2562% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.7532% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.1818% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.9245% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 92.3077% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.1818% (minimum 99%, Baseline (adaptation disabled)); skin: 75.5245% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.4828% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.0394% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.9730% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.4427% (minimum 97%, Baseline (adaptation disabled)); thymus: 26.7327% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 88.5246% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,46.8,12.3,29.6,"bone marrow: 46.8 nTPM (vital, limit 1); thymus: 29.6 nTPM (manageable, limit 5); lymph node: 12.3 nTPM (protected, limit 2); esophagus: 5.4 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000123485,HJURP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.682673,-0.502468,-0.8025
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 94.7368% (minimum 95%, Missing); adrenal gland: 95.5752% (minimum 99%, Uncertain); bone marrow: 18.7500% (minimum 99%, Missing); cerebral cortex: 96.4286% (minimum 99%, Missing); choroid plexus: 97.2973% (minimum 99%, Missing); colon: 73.9726% (minimum 97%, Missing); duodenum: 73.4694% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Uncertain); heart muscle: 97.2973% (minimum 99%, Missing); kidney: 96.4286% (minimum 99%, Missing); liver: 93.1034% (minimum 99%, Missing); lung: 89.2562% (minimum 99%, Missing); lymph node: 46.7532% (minimum 97%, Missing); pancreas: 98.1818% (minimum 99%, Missing); rectum: 67.9245% (minimum 97%, Missing); salivary gland: 92.3077% (minimum 97%, Missing); skeletal muscle: 98.1818% (minimum 99%, Missing); skin: 75.5245% (minimum 95%, Uncertain); small intestine: 74.4828% (minimum 99%, Missing); smooth muscle: 85.0394% (minimum 99%, Missing); spleen: 72.9730% (minimum 95%, Missing); stomach: 82.4427% (minimum 97%, Missing); thymus: 26.7327% (minimum 95%, Missing); urinary bladder: 88.5246% (minimum 97%, Missing)",0,1,partial,46.8,12.3,29.6,"bone marrow: 46.8 nTPM (vital, limit 1); thymus: 29.6 nTPM (manageable, limit 5); lymph node: 12.3 nTPM (protected, limit 2); esophagus: 5.4 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000123485,HJURP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.682673,-0.502468,-0.8025
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.7,4.3,2.1,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123496,IL13RA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 86.3501% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.2226% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.8617% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.6752% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.9841% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9796% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.6510% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.9154% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.3235% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.2638% (minimum 99%, Baseline (adaptation disabled)); liver: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 95.7237% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.7237% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 71.3235% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9796% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.9796% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.6441% (minimum 99%, Baseline (adaptation disabled)); thymus: 93.2692% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 87.1257% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.7,4.3,2.1,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123496,IL13RA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0173077,-0.0987425,-0.276765
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 86.3501% (minimum 99%, Missing); amygdala: 91.2226% (minimum 99%, Missing); basal ganglia: 83.8617% (minimum 99%, Missing); cerebral cortex: 92.6752% (minimum 99%, Missing); choroid plexus: 76.9841% (minimum 99%, Missing); duodenum: 98.9796% (minimum 99%, Missing); heart muscle: 97.6510% (minimum 99%, Missing); hippocampal formation: 87.9154% (minimum 99%, Missing); hypothalamus: 71.3235% (minimum 99%, Missing); kidney: 89.2638% (minimum 99%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 95.7237% (minimum 99%, Missing); midbrain: 95.7237% (minimum 99%, Missing); pituitary gland: 71.3235% (minimum 99%, Missing); small intestine: 98.9796% (minimum 99%, Missing); smooth muscle: 98.9796% (minimum 99%, Missing); spinal cord: 98.6441% (minimum 99%, Missing); thymus: 93.2692% (minimum 95%, Missing); urinary bladder: 87.1257% (minimum 97%, Missing)",0,80,unavailable,11.7,4.3,2.1,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123496,IL13RA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0173077,-0.0987425,-0.276765
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.2,2.6,2.4,"pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.4 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123500,COL10A1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2759% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.6102% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2759% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.6923% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.6102% (minimum 99%, Baseline (adaptation disabled)); colon: 96.6102% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2759% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.2759% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.4426% (minimum 99%, Baseline (adaptation disabled)); liver: 96.6102% (minimum 99%, Baseline (adaptation disabled)); lung: 67.0588% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.9355% (minimum 97%, Baseline (adaptation disabled)); pancreas: 64.0449% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.3704% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 87.6923% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.6747% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.2759% (minimum 99%, Baseline (adaptation disabled)); skin: 93.4426% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.2759% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.9355% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2759% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.3704% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.0625% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.6102% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.2,2.6,2.4,"pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.4 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123500,COL10A1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.246296,-0.283253,-0.349551
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2759% (minimum 99%, Missing); basal ganglia: 96.6102% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 98.2759% (minimum 99%, Missing); cerebral cortex: 87.6923% (minimum 99%, Missing); choroid plexus: 96.6102% (minimum 99%, Missing); colon: 96.6102% (minimum 97%, Missing); heart muscle: 95.0000% (minimum 99%, Missing); hippocampal formation: 98.2759% (minimum 99%, Missing); hypothalamus: 98.2759% (minimum 99%, Missing); kidney: 93.4426% (minimum 99%, Missing); liver: 96.6102% (minimum 99%, Missing); lung: 67.0588% (minimum 99%, Missing); lymph node: 91.9355% (minimum 97%, Missing); pancreas: 64.0449% (minimum 99%, Missing); parathyroid gland: 70.3704% (minimum 97%, Missing); pituitary gland: 95.0000% (minimum 99%, Missing); retina: 87.6923% (minimum 99%, Missing); salivary gland: 68.6747% (minimum 97%, Missing); skeletal muscle: 98.2759% (minimum 99%, Missing); skin: 93.4426% (minimum 95%, Missing); small intestine: 98.2759% (minimum 99%, Missing); smooth muscle: 91.9355% (minimum 99%, Missing); spinal cord: 98.2759% (minimum 99%, Missing); spleen: 70.3704% (minimum 95%, Missing); thyroid gland: 89.0625% (minimum 95%, Missing); urinary bladder: 96.6102% (minimum 97%, Missing)",0,80,unavailable,3.2,2.6,2.4,"pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.4 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123500,COL10A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.246296,-0.283253,-0.349551
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000123569,H2BW1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000123569,H2BW1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000123569,H2BW1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000123576,ESX1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000123576,ESX1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000123576,ESX1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000123584,MAGEA9,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000123584,MAGEA9,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000123584,MAGEA9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000123594,ATXN3L,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000123594,ATXN3L,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000123594,ATXN3L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,174.7,100.3,117.8,"bone marrow: 174.7 nTPM (vital, limit 1); thymus: 117.8 nTPM (manageable, limit 5); lymph node: 100.3 nTPM (protected, limit 2); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 2); colon: 42.6 nTPM (protected, limit 2); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 2); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); spleen: 31.8 nTPM (manageable, limit 5); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 2); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 2); skin: 19.3 nTPM (manageable, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 2); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.4 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); salivary gland: 10.5 nTPM (protected, limit 2); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000123975,CKS2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.1889% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.2485% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.5055% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.9028% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 50.8303% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.2030% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.6045% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.1606% (minimum 99%, Baseline (adaptation disabled)); colon: 80.9140% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.1321% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.7443% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.8031% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.4067% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.9617% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.9219% (minimum 99%, Baseline (adaptation disabled)); liver: 85.6736% (minimum 99%, Baseline (adaptation disabled)); lung: 88.5728% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.2933% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.8090% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7802% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.4357% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.4636% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.0163% (minimum 97%, Baseline (adaptation disabled)); retina: 86.9942% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.5055% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.2030% (minimum 99%, Baseline (adaptation disabled)); skin: 90.3452% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.9083% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.4430% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.4545% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.0282% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.1198% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.5228% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.5751% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 87.5849% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,174.7,100.3,117.8,"bone marrow: 174.7 nTPM (vital, limit 1); thymus: 117.8 nTPM (manageable, limit 5); lymph node: 100.3 nTPM (protected, limit 2); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 2); colon: 42.6 nTPM (protected, limit 2); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 2); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); spleen: 31.8 nTPM (manageable, limit 5); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 2); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 2); skin: 19.3 nTPM (manageable, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 2); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.4 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); salivary gland: 10.5 nTPM (protected, limit 2); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000123975,CKS2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.344772,-0.327067,-0.481697
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.1889% (minimum 95%, Missing); adrenal gland: 69.2485% (minimum 99%, Missing); amygdala: 94.5055% (minimum 99%, Missing); basal ganglia: 94.9028% (minimum 99%, Missing); bone marrow: 50.8303% (minimum 99%, Missing); cerebellum: 95.2030% (minimum 99%, Missing); cerebral cortex: 94.6045% (minimum 99%, Missing); choroid plexus: 94.1606% (minimum 99%, Missing); colon: 80.9140% (minimum 97%, Missing); duodenum: 81.1321% (minimum 99%, Missing); esophagus: 77.7443% (minimum 97%, Missing); heart muscle: 94.8031% (minimum 99%, Missing); hippocampal formation: 94.4067% (minimum 99%, Missing); hypothalamus: 95.9617% (minimum 99%, Missing); kidney: 83.9219% (minimum 99%, Missing); liver: 85.6736% (minimum 99%, Missing); lung: 88.5728% (minimum 99%, Missing); lymph node: 64.2933% (minimum 97%, Missing); midbrain: 95.8090% (minimum 99%, Missing); pancreas: 97.7802% (minimum 99%, Missing); parathyroid gland: 90.4357% (minimum 97%, Missing); pituitary gland: 97.4636% (minimum 99%, Missing); rectum: 82.0163% (minimum 97%, Missing); retina: 86.9942% (minimum 99%, Missing); salivary gland: 94.5055% (minimum 97%, Missing); skeletal muscle: 95.2030% (minimum 99%, Missing); skin: 90.3452% (minimum 95%, Missing); small intestine: 84.9083% (minimum 99%, Missing); smooth muscle: 91.4430% (minimum 99%, Missing); spinal cord: 95.4545% (minimum 99%, Missing); spleen: 85.0282% (minimum 95%, Missing); stomach: 90.1198% (minimum 97%, Missing); thymus: 60.5228% (minimum 95%, Missing); thyroid gland: 93.5751% (minimum 95%, Missing); urinary bladder: 87.5849% (minimum 97%, Missing)",0,1,partial,174.7,100.3,117.8,"bone marrow: 174.7 nTPM (vital, limit 1); thymus: 117.8 nTPM (manageable, limit 5); lymph node: 100.3 nTPM (protected, limit 2); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 2); colon: 42.6 nTPM (protected, limit 2); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 2); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); spleen: 31.8 nTPM (manageable, limit 5); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 2); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 2); skin: 19.3 nTPM (manageable, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 2); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.4 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); salivary gland: 10.5 nTPM (protected, limit 2); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000123975,CKS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.344772,-0.327067,-0.481697
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,10,partial,57.1,0.8,0.6,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 2); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123977,DAW1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2471% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.0492% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6220% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.8516% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 46.7351% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.6063% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.8202% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6220% (minimum 99%, Baseline (adaptation disabled)); lung: 94.1729% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6220% (minimum 99%, Baseline (adaptation disabled)); retina: 97.6608% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 85.3492% (minimum 99%, Baseline (adaptation disabled))",0,10,partial,57.1,0.8,0.6,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123977,DAW1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0381657,0.0142829,-0.522649
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2471% (minimum 99%, Missing); basal ganglia: 88.0492% (minimum 99%, Missing); cerebral cortex: 97.8516% (minimum 98%, Approved); choroid plexus: 46.7351% (minimum 99%, Missing); hippocampal formation: 92.6063% (minimum 99%, Missing); hypothalamus: 93.8202% (minimum 99%, Missing); lung: 94.1729% (minimum 98%, Approved); retina: 97.6608% (minimum 99%, Missing); skeletal muscle: 85.3492% (minimum 98%, Approved)",0,10,partial,57.1,0.8,0.6,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 2); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000123977,DAW1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0420792,0.0201186,-0.522649
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,73.2,1.5,3.2,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 6); pancreas: 11.9 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 6); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000123999,INHA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.0034% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.9203% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.6726% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.4381% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.0188% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.0601% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 86.4842% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.8294% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.6481% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.0250% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.0601% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.4690% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.0465% (minimum 99%, Baseline (adaptation disabled)); retina: 98.2507% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9237% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,73.2,1.5,3.2,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 1); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000123999,INHA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0193193,0.0153801,-0.409966
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.0034% (minimum 99%, Missing); amygdala: 95.9203% (minimum 99%, Missing); basal ganglia: 90.6726% (minimum 99%, Missing); cerebellum: 93.4381% (minimum 95%, Enhanced); choroid plexus: 98.0601% (minimum 99%, Missing); heart muscle: 86.4842% (minimum 95%, Enhanced); hippocampal formation: 95.8294% (minimum 99%, Missing); hypothalamus: 95.6481% (minimum 99%, Missing); midbrain: 98.0601% (minimum 99%, Missing); pancreas: 89.4690% (minimum 95%, Enhanced); pituitary gland: 94.0465% (minimum 99%, Missing); retina: 98.2507% (minimum 99%, Missing); spinal cord: 98.9237% (minimum 99%, Missing)",0,1,partial,73.2,1.5,3.2,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 6); pancreas: 11.9 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 6); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000123999,INHA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.409966
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,2,partial,1.4,0,0,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),56,not_established,not_triggered,,,ENSG00000124089,MC3R,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"hypothalamus: 6.6667% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,1.4,0,0,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),56,not_established,not_triggered,,,ENSG00000124089,MC3R,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.923333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"hypothalamus: 6.6667% (minimum 99%, Missing)",0,2,partial,1.4,0,0,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),56,not_established,not_triggered,,,ENSG00000124089,MC3R,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.923333
True,compatible,,True,True,False,,0,2,partial,0.9,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000124092,CTCFL,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.1818% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.1818% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.1818% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.2973% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.1818% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.1818% (minimum 99%, Baseline (adaptation disabled)); liver: 96.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1818% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.4286% (minimum 97%, Baseline (adaptation disabled)); pancreas: 95.5752% (minimum 99%, Baseline (adaptation disabled)); retina: 92.3077% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.1818% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.2973% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.9,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000124092,CTCFL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.00575221,-0.00571429,-0.0669231
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 92.3077% (minimum 95%, Enhanced); choroid plexus: 98.1818% (minimum 99%, Missing); retina: 92.3077% (minimum 99%, Missing)",0,2,partial,0.9,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000124092,CTCFL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0408257,0.0208257,-0.0669231
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,16.5,1.5,2.2,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000124103,FAM209A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 85.9932% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9258% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,16.5,1.5,2.2,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000124103,FAM209A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.028744,0.0154086,-0.130068
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 85.9932% (minimum 99%, Missing); small intestine: 98.9258% (minimum 99%, Missing)",0,80,unavailable,16.5,1.5,2.2,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000124103,FAM209A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.028744,0.0154086,-0.130068
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.2,16.2,"skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000124116,WFDC3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.9796% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.6341% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.4772% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9796% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9796% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.9796% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.9796% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4772% (minimum 99%, Baseline (adaptation disabled)); skin: 54.4944% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 95.5665% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.2,16.2,"skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000124116,WFDC3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.405056,0.0197959,-0.0436585
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.9796% (minimum 99%, Missing); choroid plexus: 94.6341% (minimum 99%, Missing); duodenum: 98.4772% (minimum 99%, Missing); hippocampal formation: 98.9796% (minimum 99%, Missing); hypothalamus: 98.9796% (minimum 99%, Missing); kidney: 98.9796% (minimum 99%, Missing); midbrain: 98.9796% (minimum 99%, Missing); retina: 98.4772% (minimum 99%, Missing); skin: 54.4944% (minimum 95%, Missing); smooth muscle: 95.5665% (minimum 99%, Missing)",0,80,unavailable,1.1,0.2,16.2,"skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000124116,WFDC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.405056,0.0197959,-0.0436585
True,compatible,,True,True,False,,0,1,partial,0.3,1.4,0.7,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000124196,GTSF1L,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.3,1.4,0.7,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000124196,GTSF1L,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0467919,0.0236044,0.00862259
True,compatible,,True,True,True,,0,1,partial,0.3,1.4,0.7,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000124196,GTSF1L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0481643,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,19.6,78.8,23.1,"parathyroid gland: 78.8 nTPM (protected, limit 2); thyroid gland: 23.1 nTPM (manageable, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 2); stomach: 15.8 nTPM (protected, limit 2); rectum: 15.2 nTPM (protected, limit 2); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 2); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); thymus: 11 nTPM (manageable, limit 5); skin: 10.8 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 2); salivary gland: 10.7 nTPM (protected, limit 2); esophagus: 10.7 nTPM (protected, limit 2); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); spleen: 10.1 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 2); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000124198,ARFGEF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 44.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.1220% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.3961% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.9222% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.2542% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.3482% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.9744% (minimum 99%, Baseline (adaptation disabled)); colon: 52.9210% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.6585% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.0038% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.2254% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.9677% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.2963% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.9934% (minimum 99%, Baseline (adaptation disabled)); liver: 56.2044% (minimum 99%, Baseline (adaptation disabled)); lung: 66.9565% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.8474% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.3196% (minimum 99%, Baseline (adaptation disabled)); pancreas: 45.1613% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 16.3482% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.4351% (minimum 99%, Baseline (adaptation disabled)); rectum: 50.3268% (minimum 97%, Baseline (adaptation disabled)); retina: 69.6833% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.0038% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 57.4627% (minimum 99%, Baseline (adaptation disabled)); skin: 58.7786% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.2308% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.1416% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.3922% (minimum 95%, Baseline (adaptation disabled)); stomach: 49.3590% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 40.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 46.8085% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.7786% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,19.6,78.8,23.1,"parathyroid gland: 78.8 nTPM (protected, limit 2); thyroid gland: 23.1 nTPM (manageable, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 2); stomach: 15.8 nTPM (protected, limit 2); rectum: 15.2 nTPM (protected, limit 2); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 2); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); thymus: 11 nTPM (manageable, limit 5); skin: 10.8 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 2); salivary gland: 10.7 nTPM (protected, limit 2); esophagus: 10.7 nTPM (protected, limit 2); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); spleen: 10.1 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 2); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000124198,ARFGEF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.55,-0.806518,-0.55
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 95%, Missing); adrenal gland: 44.0000% (minimum 99%, Missing); amygdala: 75.1220% (minimum 99%, Missing); basal ganglia: 74.3961% (minimum 99%, Missing); bone marrow: 59.9222% (minimum 99%, Missing); cerebellum: 65.2542% (minimum 99%, Missing); cerebral cortex: 62.3482% (minimum 99%, Missing); choroid plexus: 78.9744% (minimum 99%, Missing); colon: 52.9210% (minimum 97%, Missing); duodenum: 53.6585% (minimum 99%, Missing); esophagus: 59.0038% (minimum 97%, Missing); heart muscle: 54.2254% (minimum 99%, Missing); hippocampal formation: 70.9677% (minimum 99%, Missing); hypothalamus: 71.2963% (minimum 99%, Missing); kidney: 50.9934% (minimum 99%, Missing); liver: 56.2044% (minimum 99%, Missing); lung: 66.9565% (minimum 99%, Missing); lymph node: 61.8474% (minimum 97%, Missing); midbrain: 70.3196% (minimum 99%, Missing); pancreas: 45.1613% (minimum 99%, Missing); parathyroid gland: 16.3482% (minimum 97%, Missing); pituitary gland: 64.4351% (minimum 99%, Missing); rectum: 50.3268% (minimum 97%, Missing); retina: 69.6833% (minimum 99%, Missing); salivary gland: 59.0038% (minimum 97%, Missing); skeletal muscle: 57.4627% (minimum 99%, Missing); skin: 58.7786% (minimum 95%, Missing); small intestine: 59.2308% (minimum 99%, Missing); smooth muscle: 62.8571% (minimum 99%, Missing); spinal cord: 68.1416% (minimum 99%, Missing); spleen: 60.3922% (minimum 95%, Missing); stomach: 49.3590% (minimum 97%, Missing); thymus: 58.3333% (minimum 95%, Missing); thyroid gland: 40.0000% (minimum 95%, Missing); tongue: 46.8085% (minimum 97%, Missing); urinary bladder: 58.7786% (minimum 97%, Missing)",0,4,partial,19.6,78.8,23.1,"parathyroid gland: 78.8 nTPM (protected, limit 2); thyroid gland: 23.1 nTPM (manageable, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 2); stomach: 15.8 nTPM (protected, limit 2); rectum: 15.2 nTPM (protected, limit 2); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 2); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); thymus: 11 nTPM (manageable, limit 5); skin: 10.8 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 2); salivary gland: 10.7 nTPM (protected, limit 2); esophagus: 10.7 nTPM (protected, limit 2); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); spleen: 10.1 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 2); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000124198,ARFGEF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.55,-0.806518,-0.55
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000124227,ANKRD60,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.2222% (minimum 99%, Baseline (adaptation disabled)); retina: 97.2222% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 94.5946% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000124227,ANKRD60,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0222222,0.03,-0.0440541
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.2222% (minimum 99%, Missing); retina: 97.2222% (minimum 99%, Missing); skeletal muscle: 94.5946% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000124227,ANKRD60,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0222222,0.03,-0.0440541
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,0,routine_complete,944.9,3.5,0.2,"pancreas: 944.9 nTPM (vital, limit 1)",pancreas / pancreatic endocrine cells: Medium (Enhanced),55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000124232,RBPJL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 50.0000% (minimum 95%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 0.0212% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skin: 66.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 5.4054% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,944.9,3.5,0.2,"pancreas: 944.9 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2)",pancreas / pancreatic endocrine cells: Medium (Enhanced),55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000124232,RBPJL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.45,-0.915946,-0.989788
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 50.0000% (minimum 60%, Enhanced); duodenum: 66.6667% (minimum 95%, Enhanced); heart muscle: 66.6667% (minimum 95%, Enhanced); liver: 66.6667% (minimum 95%, Enhanced); pancreas: 0.0212% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 80%, Enhanced); stomach: 5.4054% (minimum 80%, Enhanced)",0,0,routine_complete,944.9,3.5,0.2,"pancreas: 944.9 nTPM (vital, limit 1)",pancreas / pancreatic endocrine cells: Medium (Enhanced),55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000124232,RBPJL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.1,-0.745946,-0.989788
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,False,,0,4,partial,24.7,0.1,0.4,"lung: 24.7 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,ENSG00000124237,CIMIP1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 98.7879% (minimum 99%, Baseline (adaptation disabled)); lung: 94.6859% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,24.7,0.1,0.4,"lung: 24.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,ENSG00000124237,CIMIP1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0490919,0.0297728,-0.0431411
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 98.7879% (minimum 99%, Missing); lung: 94.6859% (minimum 95%, Enhanced)",0,4,partial,24.7,0.1,0.4,"lung: 24.7 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,ENSG00000124237,CIMIP1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0490919,0.03,-0.00314114
True,compatible,,True,True,False,,0,4,partial,0.3,0.2,0.4,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000124260,MAGEA10,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.9130% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.8085% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9130% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9130% (minimum 99%, Baseline (adaptation disabled)); retina: 98.9130% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.9130% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,0.3,0.2,0.4,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000124260,MAGEA10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025,0.00789474,0.00849462,-0.0219149
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.8085% (minimum 98%, Approved); choroid plexus: 98.9130% (minimum 99%, Missing); retina: 98.9130% (minimum 99%, Missing)",0,4,partial,0.3,0.2,0.4,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000124260,MAGEA10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025,0.05,0.0284946,-0.0119149
True,compatible,,True,True,False,,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000124449,IRGC,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000124449,IRGC,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00931319
True,compatible,,True,True,True,,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000124449,IRGC,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00931319
True,compatible,,True,True,False,,0,3,partial,0,0.2,0,,,52,not_established,not_triggered,,,ENSG00000124467,PSG8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"parathyroid gland: 96.9231% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,0,0.2,0,,,52,not_established,not_triggered,,,ENSG00000124467,PSG8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,-0.000769231,0.01
True,compatible,,True,True,True,,0,3,partial,0,0.2,0,,,52,not_established,not_triggered,,,ENSG00000124467,PSG8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,16.5,15.1,0.5,"bone marrow: 16.5 nTPM (vital, limit 6); salivary gland: 15.1 nTPM (protected, limit 12); choroid plexus: 4.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000124490,CRISP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.7481% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,16.5,15.1,0.5,"bone marrow: 16.5 nTPM (vital, limit 1); salivary gland: 15.1 nTPM (protected, limit 2); choroid plexus: 4.1 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000124490,CRISP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0489825,0.000158103,-0.0225187
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,16.5,15.1,0.5,"bone marrow: 16.5 nTPM (vital, limit 6); salivary gland: 15.1 nTPM (protected, limit 12); choroid plexus: 4.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000124490,CRISP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.00171717
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,False,,0,5,partial,0,0,0.1,,esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000124610,H1-1,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;family_exclusion,True,True,True,"thyroid gland: 50.0000% (minimum 95%, Baseline (adaptation disabled))",0,5,partial,0,0,0.1,,esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000124610,H1-1,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.45,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;family_exclusion,True,True,True,"thyroid gland: 50.0000% (minimum 60%, Enhanced)",0,5,partial,0,0,0.1,,esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000124610,H1-1,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.1,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.1,3.6,3.9,"parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000124613,ZNF391,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.2222% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 63.4146% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.5455% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.8228% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.6506% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.5397% (minimum 99%, Baseline (adaptation disabled)); colon: 76.4706% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.3623% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.8710% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.2703% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.2222% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.8228% (minimum 99%, Baseline (adaptation disabled)); liver: 94.5455% (minimum 99%, Baseline (adaptation disabled)); lung: 74.2857% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.2857% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.7879% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.2329% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.0909% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.3623% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.4706% (minimum 97%, Baseline (adaptation disabled)); retina: 72.2222% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.2329% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.2281% (minimum 99%, Baseline (adaptation disabled)); skin: 75.3623% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.8710% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.6119% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.2703% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.6119% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.4706% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.1,3.6,3.9,"parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000124613,ZNF391,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.378571,-0.379091,-0.363494
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.3333% (minimum 95%, Missing); adrenal gland: 72.2222% (minimum 99%, Missing); amygdala: 72.2222% (minimum 99%, Missing); basal ganglia: 63.4146% (minimum 99%, Missing); bone marrow: 94.5455% (minimum 99%, Missing); cerebellum: 65.8228% (minimum 99%, Missing); cerebral cortex: 62.6506% (minimum 99%, Missing); choroid plexus: 82.5397% (minimum 99%, Missing); colon: 76.4706% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); esophagus: 75.3623% (minimum 97%, Missing); heart muscle: 83.8710% (minimum 99%, Missing); hippocampal formation: 70.2703% (minimum 99%, Missing); hypothalamus: 72.2222% (minimum 99%, Missing); kidney: 65.8228% (minimum 99%, Missing); liver: 94.5455% (minimum 99%, Missing); lung: 74.2857% (minimum 99%, Missing); lymph node: 74.2857% (minimum 97%, Missing); midbrain: 78.7879% (minimum 99%, Missing); pancreas: 71.2329% (minimum 99%, Missing); parathyroid gland: 59.0909% (minimum 97%, Missing); pituitary gland: 75.3623% (minimum 99%, Missing); rectum: 76.4706% (minimum 97%, Missing); retina: 72.2222% (minimum 99%, Missing); salivary gland: 71.2329% (minimum 97%, Missing); skeletal muscle: 91.2281% (minimum 99%, Missing); skin: 75.3623% (minimum 95%, Missing); small intestine: 83.8710% (minimum 99%, Missing); smooth muscle: 69.3333% (minimum 99%, Missing); spinal cord: 77.6119% (minimum 99%, Missing); spleen: 70.2703% (minimum 95%, Missing); stomach: 77.6119% (minimum 97%, Missing); thymus: 80.0000% (minimum 95%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); tongue: 86.6667% (minimum 97%, Missing); urinary bladder: 76.4706% (minimum 97%, Missing)",0,80,unavailable,3.1,3.6,3.9,"parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000124613,ZNF391,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.378571,-0.379091,-0.363494
True,compatible,,True,True,False,,0,2,partial,0.5,0.4,0.4,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000124678,TCP11,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.5,0.4,0.4,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000124678,TCP11,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0487941,0.0287941,0.00849307
True,compatible,,True,True,True,,0,2,partial,0.5,0.4,0.4,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000124678,TCP11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0496982,0.0290953,0.0090953
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.5,1.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,ENSG00000124721,DNAH8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 98.7013% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.8272% (minimum 97%, Baseline (adaptation disabled)); skin: 82.6087% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.7013% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.4762% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.5,1.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,ENSG00000124721,DNAH8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.123913,-0.0317284,-0.00298701
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 98.7013% (minimum 99%, Missing); lymph node: 93.8272% (minimum 97%, Missing); skin: 82.6087% (minimum 95%, Missing); small intestine: 98.7013% (minimum 99%, Missing); spleen: 90.4762% (minimum 95%, Missing)",0,80,unavailable,0.1,0.5,1.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,ENSG00000124721,DNAH8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.123913,-0.0317284,-0.00298701
True,compatible,,True,True,False,,0,5,partial,0,0.3,0,,,49,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000124812,CRISP1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0,0.3,0,,,49,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000124812,CRISP1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0298048,0.01
True,compatible,,True,True,True,,0,5,partial,0,0.3,0,,,49,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000124812,CRISP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,1,partial,0.4,0.1,0,,retina / photoreceptor cells: High (Supported),63,not_established,not_triggered,,,ENSG00000124818,OPN5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"heart muscle: 86.2069% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); tongue: 96.1538% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,0.4,0.1,0,,retina / photoreceptor cells: High (Supported),63,not_established,not_triggered,,,ENSG00000124818,OPN5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,-0.00846154,-0.127931
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"heart muscle: 86.2069% (minimum 97%, Supported); skeletal muscle: 96.1538% (minimum 97%, Supported); tongue: 96.1538% (minimum 97%, Missing)",0,1,partial,0.4,0.1,0,,retina / photoreceptor cells: High (Supported),63,not_established,not_triggered,,,ENSG00000124818,OPN5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,-0.00846154,-0.107931
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000124900,TRIM51,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000124900,TRIM51,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000124900,TRIM51,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,1.1,0,0.4,"retina: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000125207,PIWIL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 98.3412% (minimum 99%, Baseline (adaptation disabled)); retina: 97.4178% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.1,0,0.4,"retina: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000125207,PIWIL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0404535,0.03,-0.0158216
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 98.3412% (minimum 99%, Missing); retina: 97.4178% (minimum 99%, Missing)",0,3,partial,1.1,0,0.4,"retina: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000125207,PIWIL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0158216
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,9.6,38,10.2,"lymph node: 38 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 6); thymus: 7.7 nTPM (manageable, limit 5)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000125245,GPR18,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.9507% (minimum 99%, Baseline (adaptation disabled)); colon: 93.3824% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.7007% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.2121% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.6923% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.6923% (minimum 99%, Baseline (adaptation disabled)); liver: 93.3824% (minimum 99%, Baseline (adaptation disabled)); lung: 94.7761% (minimum 99%, Baseline (adaptation disabled)); lymph node: 25.0493% (minimum 97%, Baseline (adaptation disabled)); rectum: 93.3824% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 93.3824% (minimum 97%, Baseline (adaptation disabled)); small intestine: 76.5060% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.4496% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.4585% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.4366% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.2549% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 86.3946% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,9.6,38,10.2,"lymph node: 38 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000125245,GPR18,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.395415,-0.719507,-0.420493
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.9507% (minimum 95%, Enhanced); duodenum: 92.7007% (minimum 95%, Enhanced); liver: 93.3824% (minimum 95%, Enhanced); lung: 94.7761% (minimum 95%, Enhanced); lymph node: 25.0493% (minimum 97%, Missing); small intestine: 76.5060% (minimum 95%, Enhanced); spinal cord: 98.4496% (minimum 99%, Missing); spleen: 55.4585% (minimum 95%, Missing); thymus: 62.2549% (minimum 95%, Missing)",0,0,routine_complete,9.6,38,10.2,"lymph node: 38 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 6); thymus: 7.7 nTPM (manageable, limit 5)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000125245,GPR18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.395415,-0.719507,-0.380493
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,9.2,2.7,2.2,"bone marrow: 9.2 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000125319,HROB,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.8000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.5217% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.2301% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2301% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.6798% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.0678% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.3684% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.2301% (minimum 99%, Baseline (adaptation disabled)); colon: 92.5000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.2773% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.4348% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.0678% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2301% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.5217% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.5217% (minimum 99%, Baseline (adaptation disabled)); liver: 94.8718% (minimum 99%, Baseline (adaptation disabled)); lung: 94.8718% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.4016% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.3684% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.3684% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.5217% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.5217% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.7355% (minimum 97%, Baseline (adaptation disabled)); retina: 97.3684% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.0678% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 86.7188% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.8718% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2301% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.2439% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.8718% (minimum 97%, Baseline (adaptation disabled)); thymus: 83.4586% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.8718% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,9.2,2.7,2.2,"bone marrow: 9.2 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000125319,HROB,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.115414,-0.165652,-0.443202
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.8000% (minimum 95%, Missing); adrenal gland: 96.5217% (minimum 99%, Missing); amygdala: 98.2301% (minimum 99%, Missing); basal ganglia: 98.2301% (minimum 99%, Missing); bone marrow: 54.6798% (minimum 99%, Missing); cerebellum: 94.0678% (minimum 99%, Missing); cerebral cortex: 97.3684% (minimum 99%, Missing); choroid plexus: 98.2301% (minimum 99%, Missing); colon: 92.5000% (minimum 97%, Missing); duodenum: 93.2773% (minimum 99%, Missing); esophagus: 80.4348% (minimum 97%, Missing); heart muscle: 94.0678% (minimum 99%, Missing); hippocampal formation: 98.2301% (minimum 99%, Missing); hypothalamus: 96.5217% (minimum 99%, Missing); kidney: 96.5217% (minimum 99%, Missing); liver: 94.8718% (minimum 99%, Missing); lung: 94.8718% (minimum 99%, Missing); lymph node: 87.4016% (minimum 97%, Missing); midbrain: 97.3684% (minimum 99%, Missing); pancreas: 97.3684% (minimum 99%, Missing); parathyroid gland: 96.5217% (minimum 97%, Missing); pituitary gland: 96.5217% (minimum 99%, Missing); rectum: 91.7355% (minimum 97%, Missing); retina: 97.3684% (minimum 99%, Missing); salivary gland: 94.0678% (minimum 97%, Missing); skeletal muscle: 92.5000% (minimum 99%, Missing); skin: 86.7188% (minimum 95%, Missing); small intestine: 92.5000% (minimum 99%, Missing); smooth muscle: 94.8718% (minimum 99%, Uncertain); spinal cord: 98.2301% (minimum 99%, Missing); spleen: 90.2439% (minimum 95%, Missing); stomach: 94.8718% (minimum 97%, Missing); thymus: 83.4586% (minimum 95%, Missing); urinary bladder: 94.8718% (minimum 97%, Missing)",0,0,routine_complete,9.2,2.7,2.2,"bone marrow: 9.2 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000125319,HROB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.115414,-0.165652,-0.443202
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,12.1,4.2,3.2,"cerebellum: 12.1 nTPM (vital, limit 2); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2); tongue: 4.2 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 4); adrenal gland: 3.2 nTPM (vital, limit 2); colon: 2.7 nTPM (protected, limit 2); choroid plexus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125388,GRK4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.8356% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.7765% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.1974% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.7380% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.9340% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.2556% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.4468% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.8356% (minimum 99%, Baseline (adaptation disabled)); colon: 93.8356% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.6247% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.0280% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.7380% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.6333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.5776% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.1389% (minimum 99%, Baseline (adaptation disabled)); liver: 95.5814% (minimum 99%, Baseline (adaptation disabled)); lung: 95.3596% (minimum 99%, Baseline (adaptation disabled)); midbrain: 87.8205% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.7689% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.7285% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.2611% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.9340% (minimum 97%, Baseline (adaptation disabled)); retina: 80.7466% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.6219% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.9344% (minimum 99%, Baseline (adaptation disabled)); skin: 94.7005% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.7059% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.3596% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.3445% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.4091% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.7765% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.7285% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.9192% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,12.1,4.2,3.2,"cerebellum: 12.1 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); salivary gland: 2.8 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); choroid plexus: 2.7 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125388,GRK4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0222348,-0.0627152,-0.217444
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.7765% (minimum 98%, Approved); amygdala: 88.1974% (minimum 99%, Missing); basal ganglia: 89.7380% (minimum 99%, Missing); bone marrow: 96.9340% (minimum 98%, Approved); cerebellum: 77.2556% (minimum 98%, Approved); cerebral cortex: 87.4468% (minimum 99%, Missing); choroid plexus: 93.8356% (minimum 99%, Missing); colon: 93.8356% (minimum 97%, Missing); duodenum: 97.6247% (minimum 98%, Approved); heart muscle: 89.7380% (minimum 98%, Approved); hippocampal formation: 87.6333% (minimum 99%, Missing); hypothalamus: 88.5776% (minimum 99%, Missing); kidney: 95.1389% (minimum 98%, Approved); liver: 95.5814% (minimum 98%, Approved); lung: 95.3596% (minimum 98%, Approved); midbrain: 87.8205% (minimum 99%, Missing); pancreas: 88.7689% (minimum 98%, Approved); parathyroid gland: 90.7285% (minimum 95%, Approved); pituitary gland: 87.2611% (minimum 99%, Missing); retina: 80.7466% (minimum 99%, Missing); salivary gland: 93.6219% (minimum 95%, Approved); skeletal muscle: 89.9344% (minimum 98%, Approved); small intestine: 96.7059% (minimum 98%, Approved); smooth muscle: 95.3596% (minimum 98%, Approved); spinal cord: 86.3445% (minimum 99%, Missing); stomach: 93.4091% (minimum 95%, Approved); tongue: 90.7285% (minimum 97%, Missing); urinary bladder: 94.9192% (minimum 95%, Approved)",0,7,partial,12.1,4.2,3.2,"cerebellum: 12.1 nTPM (vital, limit 2); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2); tongue: 4.2 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 4); adrenal gland: 3.2 nTPM (vital, limit 2); colon: 2.7 nTPM (protected, limit 2); choroid plexus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125388,GRK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0125293,-0.0627152,-0.207444
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,2.5,0.4,0.7,"choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125409,TEKT3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.4194% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.4856% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3547% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.4194% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.5696% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.1061% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.7949% (minimum 99%, Baseline (adaptation disabled)); lung: 97.4194% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.6928% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7346% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1061% (minimum 99%, Baseline (adaptation disabled)); retina: 98.0519% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.6928% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.3713% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,2.5,0.4,0.7,"cerebellum: 2.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125409,TEKT3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0273463,0.0169281,-0.0664526
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.4194% (minimum 99%, Missing); basal ganglia: 96.4856% (minimum 99%, Missing); cerebellum: 92.3547% (minimum 95%, Enhanced); choroid plexus: 95.5696% (minimum 99%, Missing); hippocampal formation: 97.1061% (minimum 99%, Missing); hypothalamus: 96.7949% (minimum 99%, Missing); lung: 97.4194% (minimum 99%, Missing); midbrain: 98.6928% (minimum 99%, Missing); pituitary gland: 97.1061% (minimum 99%, Missing); retina: 98.0519% (minimum 99%, Missing); spinal cord: 98.3713% (minimum 99%, Missing)",0,5,partial,2.5,0.4,0.7,"choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125409,TEKT3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0466997,0.0266997,-0.0343038
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.2,0.7,1,"kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125531,FNDC11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 98.8701% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.2,0.7,1,"kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125531,FNDC11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.040566,0.0233775,-0.00129944
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 98.8701% (minimum 99%, Missing)",0,80,unavailable,1.2,0.7,1,"kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125531,FNDC11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.040566,0.0233775,-0.00129944
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000125533,BHLHE23,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000125533,BHLHE23,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.45,0.03,-0.323333
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 66.6667% (minimum 99%, Missing); thymus: 50.0000% (minimum 95%, Missing)",0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000125533,BHLHE23,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.45,0.03,-0.323333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,25.2,15.4,11.8,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 2); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 10); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 2); skin: 10.7 nTPM (manageable, limit 5); rectum: 10.3 nTPM (protected, limit 2); lymph node: 10.1 nTPM (protected, limit 2); tongue: 9.9 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 2); salivary gland: 8.8 nTPM (protected, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 2); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); hippocampal formation: 6.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000125633,CCDC93,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8282% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 47.9554% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.1791% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 59.7222% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 37.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 45.1049% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 59.1743% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 46.4029% (minimum 99%, Baseline (adaptation disabled)); colon: 54.2017% (minimum 97%, Baseline (adaptation disabled)); duodenum: 52.6531% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.1791% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 38.5075% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.1515% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.4286% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.5893% (minimum 99%, Baseline (adaptation disabled)); liver: 62.9268% (minimum 99%, Baseline (adaptation disabled)); lung: 53.0864% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.0870% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.5468% (minimum 99%, Baseline (adaptation disabled)); pancreas: 50.3906% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 45.5830% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 45.2632% (minimum 99%, Baseline (adaptation disabled)); rectum: 55.6034% (minimum 97%, Baseline (adaptation disabled)); retina: 33.8583% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.4470% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.9881% (minimum 99%, Baseline (adaptation disabled)); skin: 54.6610% (minimum 95%, Baseline (adaptation disabled)); small intestine: 50.9881% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.3188% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.1791% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.2267% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.4470% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.8282% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.8689% (minimum 95%, Baseline (adaptation disabled)); tongue: 56.5789% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.8491% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,25.2,15.4,11.8,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 2); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 5); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 2); skin: 10.7 nTPM (manageable, limit 5); rectum: 10.3 nTPM (protected, limit 2); lymph node: 10.1 nTPM (protected, limit 2); tongue: 9.9 nTPM (protected, limit 2); adipose tissue: 9.8 nTPM (manageable, limit 5); thymus: 9.8 nTPM (manageable, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); salivary gland: 8.8 nTPM (protected, limit 2); stomach: 8.8 nTPM (protected, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 2); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000125633,CCDC93,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.427733,-0.51417,-0.651417
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8282% (minimum 90%, Approved); adrenal gland: 47.9554% (minimum 99%, Missing); amygdala: 64.1791% (minimum 99%, Missing); basal ganglia: 59.7222% (minimum 99%, Missing); bone marrow: 37.5000% (minimum 98%, Approved); cerebellum: 45.1049% (minimum 99%, Missing); cerebral cortex: 59.1743% (minimum 99%, Missing); choroid plexus: 46.4029% (minimum 99%, Missing); colon: 54.2017% (minimum 97%, Missing); duodenum: 52.6531% (minimum 99%, Missing); esophagus: 64.1791% (minimum 97%, Missing); heart muscle: 38.5075% (minimum 99%, Missing); hippocampal formation: 65.1515% (minimum 99%, Missing); hypothalamus: 61.4286% (minimum 99%, Missing); kidney: 57.5893% (minimum 99%, Missing); liver: 62.9268% (minimum 99%, Missing); lung: 53.0864% (minimum 99%, Missing); lymph node: 56.0870% (minimum 97%, Missing); midbrain: 63.5468% (minimum 99%, Missing); pancreas: 50.3906% (minimum 99%, Missing); parathyroid gland: 45.5830% (minimum 97%, Missing); pituitary gland: 45.2632% (minimum 99%, Missing); rectum: 55.6034% (minimum 97%, Missing); retina: 33.8583% (minimum 99%, Missing); salivary gland: 59.4470% (minimum 97%, Missing); skeletal muscle: 50.9881% (minimum 99%, Missing); skin: 54.6610% (minimum 95%, Missing); small intestine: 50.9881% (minimum 99%, Missing); smooth muscle: 62.3188% (minimum 99%, Missing); spinal cord: 64.1791% (minimum 99%, Missing); spleen: 52.2267% (minimum 90%, Approved); stomach: 59.4470% (minimum 97%, Missing); thymus: 56.8282% (minimum 95%, Missing); thyroid gland: 52.8689% (minimum 95%, Missing); tongue: 56.5789% (minimum 97%, Missing); urinary bladder: 60.8491% (minimum 97%, Missing)",0,5,partial,25.2,15.4,11.8,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 2); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 10); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 2); skin: 10.7 nTPM (manageable, limit 5); rectum: 10.3 nTPM (protected, limit 2); lymph node: 10.1 nTPM (protected, limit 2); tongue: 9.9 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 2); salivary gland: 8.8 nTPM (protected, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 2); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); hippocampal formation: 6.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000125633,CCDC93,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.421311,-0.51417,-0.651417
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000125788,DEFB126,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000125788,DEFB126,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.00992008
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000125788,DEFB126,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.00992008
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000125815,CST8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000125815,CST8,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00541284
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000125815,CST8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00541284
True,compatible,,True,True,False,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000125816,NKX2-4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 68.7500% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 84.6154% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000125816,NKX2-4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.3025
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 68.7500% (minimum 99%, Missing); pituitary gland: 84.6154% (minimum 99%, Missing)",0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000125816,NKX2-4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.3025
True,compatible,,True,True,False,,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,ENSG00000125823,CSTL1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 94.4444% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,ENSG00000125823,CSTL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,-0.0255556,0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 94.4444% (minimum 97%, Missing)",0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,ENSG00000125823,CSTL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,-0.0255556,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,5.2,1.4,2.4,"spinal cord: 5.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125864,BFSP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.0833% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.7119% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 53.6232% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.2439% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.2727% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.8125% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 56.0606% (minimum 99%, Baseline (adaptation disabled)); colon: 74.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.5000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.7234% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.0909% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.7931% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.6849% (minimum 99%, Baseline (adaptation disabled)); liver: 92.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 69.8113% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.7119% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.0714% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.7234% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.4348% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.2439% (minimum 97%, Baseline (adaptation disabled)); retina: 92.5000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.5490% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 78.7234% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.0909% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.7234% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 41.5730% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.2439% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.4348% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.8718% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.6557% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.2439% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 74.0000% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,5.2,1.4,2.4,"spinal cord: 5.2 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125864,BFSP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.343443,-0.24451,-0.57427
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 74.0000% (minimum 95%, Enhanced); amygdala: 62.7119% (minimum 99%, Missing); basal ganglia: 53.6232% (minimum 99%, Missing); bone marrow: 90.2439% (minimum 95%, Enhanced); cerebellum: 67.2727% (minimum 95%, Enhanced); cerebral cortex: 57.8125% (minimum 95%, Enhanced); choroid plexus: 56.0606% (minimum 99%, Missing); colon: 74.0000% (minimum 80%, Enhanced); duodenum: 92.5000% (minimum 95%, Enhanced); esophagus: 78.7234% (minimum 80%, Enhanced); heart muscle: 84.0909% (minimum 95%, Enhanced); hippocampal formation: 63.7931% (minimum 99%, Missing); hypothalamus: 61.6667% (minimum 99%, Missing); kidney: 50.6849% (minimum 95%, Enhanced); liver: 92.5000% (minimum 95%, Enhanced); lung: 69.8113% (minimum 95%, Enhanced); midbrain: 62.7119% (minimum 99%, Missing); pancreas: 66.0714% (minimum 95%, Enhanced); parathyroid gland: 78.7234% (minimum 80%, Enhanced); pituitary gland: 80.4348% (minimum 99%, Missing); retina: 92.5000% (minimum 99%, Missing); salivary gland: 72.5490% (minimum 80%, Enhanced); skeletal muscle: 92.5000% (minimum 95%, Enhanced); small intestine: 84.0909% (minimum 95%, Enhanced); smooth muscle: 78.7234% (minimum 95%, Enhanced); spinal cord: 41.5730% (minimum 99%, Missing); thymus: 94.8718% (minimum 95%, Missing); tongue: 90.2439% (minimum 97%, Missing); urinary bladder: 74.0000% (minimum 80%, Enhanced)",0,1,partial,5.2,1.4,2.4,"spinal cord: 5.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000125864,BFSP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.00128205,-0.0745098,-0.57427
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,5,partial,19.8,0.2,1.3,"pancreas: 19.8 nTPM (vital, limit 2); choroid plexus: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000125888,BANF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.8018% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.4094% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,19.8,0.2,1.3,"pancreas: 19.8 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000125888,BANF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0380184,0.0281378,-0.145906
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.8018% (minimum 99%, Missing); pancreas: 84.4094% (minimum 98%, Approved)",0,5,partial,19.8,0.2,1.3,"pancreas: 19.8 nTPM (vital, limit 2); choroid plexus: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000125888,BANF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.049068,0.03,-0.135906
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,2,partial,2.7,1.1,1.5,,kidney / cells in tubules: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,ENSG00000125900,SIRPD,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 95.4160% (minimum 99%, Baseline (adaptation disabled)); lung: 96.7298% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,2.7,1.1,1.5,"bone marrow: 2.7 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,ENSG00000125900,SIRPD,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0240035,0.0108028,-0.0358404
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,2.7,1.1,1.5,,kidney / cells in tubules: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,ENSG00000125900,SIRPD,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00415959
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000125903,DEFB129,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000125903,DEFB129,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000125903,DEFB129,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.2,9.6,0.9,"salivary gland: 9.6 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000125965,GDF5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.7059% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.7500% (minimum 99%, Baseline (adaptation disabled)); colon: 42.3077% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 73.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.5714% (minimum 99%, Baseline (adaptation disabled)); lung: 33.3333% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.6667% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 39.2857% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.6667% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 10.2804% (minimum 97%, Baseline (adaptation disabled)); skin: 91.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.7059% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.6667% (minimum 99%, Baseline (adaptation disabled)); stomach: 91.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.6154% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.6154% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2.2,9.6,0.9,"salivary gland: 9.6 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000125965,GDF5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4,-0.867196,-0.656667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 95%, Missing); adrenal gland: 91.6667% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 64.7059% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 99%, Missing); choroid plexus: 68.7500% (minimum 99%, Missing); colon: 42.3077% (minimum 97%, Missing); heart muscle: 73.3333% (minimum 99%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 91.6667% (minimum 99%, Missing); kidney: 78.5714% (minimum 99%, Missing); lung: 33.3333% (minimum 99%, Missing); midbrain: 91.6667% (minimum 99%, Missing); pituitary gland: 39.2857% (minimum 99%, Missing); rectum: 91.6667% (minimum 97%, Missing); salivary gland: 10.2804% (minimum 97%, Missing); skin: 91.6667% (minimum 95%, Missing); small intestine: 91.6667% (minimum 99%, Missing); smooth muscle: 64.7059% (minimum 99%, Missing); spinal cord: 91.6667% (minimum 99%, Missing); stomach: 91.6667% (minimum 97%, Missing); thymus: 84.6154% (minimum 95%, Missing); thyroid gland: 84.6154% (minimum 95%, Missing)",0,80,unavailable,2.2,9.6,0.9,"salivary gland: 9.6 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000125965,GDF5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4,-0.867196,-0.656667
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000125975,C20orf173,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000125975,C20orf173,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0442363,0.03,0.00710983
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000125975,C20orf173,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0442363,0.03,0.00710983
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,12,partial,30.9,14.5,18.5,"bone marrow: 30.9 nTPM (vital, limit 1); thymus: 18.5 nTPM (manageable, limit 5); spleen: 14.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); liver: 14.3 nTPM (vital, limit 1); skin: 13.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 2); esophagus: 10.4 nTPM (protected, limit 2); lung: 10.3 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); colon: 10.3 nTPM (protected, limit 2); pancreas: 10.1 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 2); heart muscle: 9.1 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 2); parathyroid gland: 8.5 nTPM (protected, limit 2); duodenum: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000126216,TUBGCP3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.7944% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.9344% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.7764% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 67.6349% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 34.5339% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 58.0071% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.1783% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.9904% (minimum 99%, Baseline (adaptation disabled)); colon: 61.2782% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.7258% (minimum 99%, Baseline (adaptation disabled)); esophagus: 61.0487% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.1732% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.9167% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.2008% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.9919% (minimum 99%, Baseline (adaptation disabled)); liver: 53.2680% (minimum 99%, Baseline (adaptation disabled)); lung: 61.2782% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.9221% (minimum 97%, Baseline (adaptation disabled)); midbrain: 67.3554% (minimum 99%, Baseline (adaptation disabled)); pancreas: 61.7424% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.7258% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.2008% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.6923% (minimum 97%, Baseline (adaptation disabled)); retina: 59.0580% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.9772% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.4229% (minimum 99%, Baseline (adaptation disabled)); skin: 54.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.9265% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.3944% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.4521% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.9221% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.6719% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.8391% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.2782% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.4618% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.5948% (minimum 97%, Baseline (adaptation disabled))",0,12,partial,30.9,14.5,18.5,"bone marrow: 30.9 nTPM (vital, limit 1); thymus: 18.5 nTPM (manageable, limit 5); spleen: 14.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); liver: 14.3 nTPM (vital, limit 1); skin: 13.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 2); esophagus: 10.4 nTPM (protected, limit 2); lung: 10.3 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); colon: 10.3 nTPM (protected, limit 2); pancreas: 10.1 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 2); heart muscle: 9.1 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 2); parathyroid gland: 8.5 nTPM (protected, limit 2); duodenum: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000126216,TUBGCP3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.481609,-0.440779,-0.644661
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.7944% (minimum 95%, Missing); adrenal gland: 62.9344% (minimum 99%, Missing); amygdala: 68.7764% (minimum 99%, Missing); basal ganglia: 67.6349% (minimum 99%, Missing); bone marrow: 34.5339% (minimum 99%, Missing); cerebellum: 58.0071% (minimum 99%, Missing); cerebral cortex: 63.1783% (minimum 99%, Missing); choroid plexus: 77.9904% (minimum 99%, Missing); colon: 61.2782% (minimum 97%, Missing); duodenum: 65.7258% (minimum 99%, Missing); esophagus: 61.0487% (minimum 97%, Missing); heart muscle: 64.1732% (minimum 99%, Missing); hippocampal formation: 67.9167% (minimum 99%, Missing); hypothalamus: 68.2008% (minimum 99%, Missing); kidney: 65.9919% (minimum 99%, Missing); liver: 53.2680% (minimum 99%, Missing); lung: 61.2782% (minimum 99%, Missing); lymph node: 52.9221% (minimum 97%, Missing); midbrain: 67.3554% (minimum 99%, Missing); pancreas: 61.7424% (minimum 99%, Missing); parathyroid gland: 65.7258% (minimum 97%, Missing); pituitary gland: 68.2008% (minimum 99%, Missing); rectum: 62.6923% (minimum 97%, Missing); retina: 59.0580% (minimum 99%, Missing); salivary gland: 61.9772% (minimum 97%, Missing); skeletal muscle: 58.4229% (minimum 99%, Missing); skin: 54.3333% (minimum 95%, Missing); small intestine: 59.9265% (minimum 99%, Missing); smooth muscle: 57.3944% (minimum 99%, Missing); spinal cord: 62.4521% (minimum 99%, Missing); spleen: 52.9221% (minimum 95%, Missing); stomach: 63.6719% (minimum 97%, Missing); thymus: 46.8391% (minimum 95%, Missing); thyroid gland: 61.2782% (minimum 95%, Missing); tongue: 65.4618% (minimum 97%, Missing); urinary bladder: 60.5948% (minimum 97%, Missing)",0,12,partial,30.9,14.5,18.5,"bone marrow: 30.9 nTPM (vital, limit 1); thymus: 18.5 nTPM (manageable, limit 5); spleen: 14.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 2); liver: 14.3 nTPM (vital, limit 1); skin: 13.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 2); esophagus: 10.4 nTPM (protected, limit 2); lung: 10.3 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); colon: 10.3 nTPM (protected, limit 2); pancreas: 10.1 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 2); heart muscle: 9.1 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 2); parathyroid gland: 8.5 nTPM (protected, limit 2); duodenum: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000126216,TUBGCP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.481609,-0.440779,-0.644661
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,48.7,32.3,27.9,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 2); spleen: 27.9 nTPM (manageable, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); thymus: 12.2 nTPM (manageable, limit 5); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 2); salivary gland: 7.6 nTPM (protected, limit 2); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); urinary bladder: 6.9 nTPM (protected, limit 2); thyroid gland: 6.9 nTPM (manageable, limit 5); midbrain: 6.8 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); colon: 6.2 nTPM (protected, limit 2); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000126246,IGFLR1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 46.7626% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 38.0117% (minimum 99%, Baseline (adaptation disabled)); amygdala: 52.8455% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.5217% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 32.1782% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.9048% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 59.0909% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 54.6218% (minimum 99%, Baseline (adaptation disabled)); colon: 51.1811% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.2787% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.1068% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.1852% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.0175% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.5556% (minimum 99%, Baseline (adaptation disabled)); kidney: 32.3383% (minimum 99%, Baseline (adaptation disabled)); liver: 11.7754% (minimum 99%, Baseline (adaptation disabled)); lung: 37.1429% (minimum 99%, Baseline (adaptation disabled)); lymph node: 16.7526% (minimum 97%, Baseline (adaptation disabled)); midbrain: 48.8722% (minimum 99%, Baseline (adaptation disabled)); pancreas: 41.9355% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.2785% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 54.6218% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.1811% (minimum 97%, Baseline (adaptation disabled)); retina: 60.7477% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 46.0993% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.1852% (minimum 99%, Baseline (adaptation disabled)); skin: 61.3208% (minimum 95%, Baseline (adaptation disabled)); small intestine: 33.6788% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.7477% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 46.4286% (minimum 99%, Baseline (adaptation disabled)); spleen: 18.8953% (minimum 95%, Baseline (adaptation disabled)); stomach: 46.0993% (minimum 97%, Baseline (adaptation disabled)); thymus: 34.7594% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.5075% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.4706% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 48.5075% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,48.7,32.3,27.9,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 2); spleen: 27.9 nTPM (manageable, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); thymus: 12.2 nTPM (manageable, limit 5); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 2); salivary gland: 7.6 nTPM (protected, limit 2); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); urinary bladder: 6.9 nTPM (protected, limit 2); thyroid gland: 6.9 nTPM (manageable, limit 5); midbrain: 6.8 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); colon: 6.2 nTPM (protected, limit 2); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000126246,IGFLR1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.761047,-0.802474,-0.872246
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 46.7626% (minimum 95%, Missing); adrenal gland: 38.0117% (minimum 99%, Missing); amygdala: 52.8455% (minimum 99%, Missing); basal ganglia: 56.5217% (minimum 99%, Missing); bone marrow: 32.1782% (minimum 99%, Uncertain); cerebellum: 61.9048% (minimum 99%, Missing); cerebral cortex: 59.0909% (minimum 99%, Missing); choroid plexus: 54.6218% (minimum 99%, Missing); colon: 51.1811% (minimum 97%, Missing); duodenum: 53.2787% (minimum 99%, Missing); esophagus: 63.1068% (minimum 97%, Uncertain); heart muscle: 60.1852% (minimum 99%, Missing); hippocampal formation: 57.0175% (minimum 99%, Missing); hypothalamus: 55.5556% (minimum 99%, Missing); kidney: 32.3383% (minimum 99%, Missing); liver: 11.7754% (minimum 99%, Missing); lung: 37.1429% (minimum 99%, Missing); lymph node: 16.7526% (minimum 97%, Missing); midbrain: 48.8722% (minimum 99%, Missing); pancreas: 41.9355% (minimum 99%, Missing); parathyroid gland: 82.2785% (minimum 97%, Missing); pituitary gland: 54.6218% (minimum 99%, Missing); rectum: 51.1811% (minimum 97%, Missing); retina: 60.7477% (minimum 99%, Missing); salivary gland: 46.0993% (minimum 97%, Uncertain); skeletal muscle: 60.1852% (minimum 99%, Missing); skin: 61.3208% (minimum 95%, Uncertain); small intestine: 33.6788% (minimum 99%, Missing); smooth muscle: 60.7477% (minimum 99%, Uncertain); spinal cord: 46.4286% (minimum 99%, Missing); spleen: 18.8953% (minimum 95%, Missing); stomach: 46.0993% (minimum 97%, Missing); thymus: 34.7594% (minimum 95%, Missing); thyroid gland: 48.5075% (minimum 95%, Missing); tongue: 76.4706% (minimum 97%, Missing); urinary bladder: 48.5075% (minimum 97%, Missing)",0,1,partial,48.7,32.3,27.9,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 2); spleen: 27.9 nTPM (manageable, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); thymus: 12.2 nTPM (manageable, limit 5); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 2); salivary gland: 7.6 nTPM (protected, limit 2); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); urinary bladder: 6.9 nTPM (protected, limit 2); thyroid gland: 6.9 nTPM (manageable, limit 5); midbrain: 6.8 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); colon: 6.2 nTPM (protected, limit 2); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000126246,IGFLR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.761047,-0.802474,-0.872246
True,compatible,,True,True,False,,0,3,partial,1.4,0.9,1.7,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000126467,TSKS,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 98.8146% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.4,0.9,1.7,"heart muscle: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000126467,TSKS,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0356419,0.0223469,-0.00185436
True,compatible,,True,True,True,,0,3,partial,1.4,0.9,1.7,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000126467,TSKS,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0474359,0.03,0.00914384
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,18,47123.7,0.7,"salivary gland: 47123.7 nTPM (protected, limit 4); pancreas: 18 nTPM (vital, limit 2); heart muscle: 4.3 nTPM (vital, limit 2)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000126550,HTN1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.3793% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 55.2083% (minimum 99%, Baseline (adaptation disabled)); pancreas: 22.7468% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 0.0112% (minimum 97%, Baseline (adaptation disabled)); skin: 88.3333% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,18,47123.7,0.7,"salivary gland: 47123.7 nTPM (protected, limit 2); pancreas: 18 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000126550,HTN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0666667,-0.969888,-0.762532
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.3793% (minimum 98%, Approved); heart muscle: 55.2083% (minimum 98%, Approved); pancreas: 22.7468% (minimum 98%, Approved); salivary gland: 0.0112% (minimum 95%, Approved); skin: 88.3333% (minimum 90%, Approved)",0,3,partial,18,47123.7,0.7,"salivary gland: 47123.7 nTPM (protected, limit 4); pancreas: 18 nTPM (vital, limit 2); heart muscle: 4.3 nTPM (vital, limit 2)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000126550,HTN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0166667,-0.949888,-0.752532
True,compatible,,True,True,False,,0,2,partial,0.1,0.1,0.2,,,52,not_established,not_triggered,,,ENSG00000126752,SSX1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.6301% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.1,0.1,0.2,,,52,not_established,not_triggered,,,ENSG00000126752,SSX1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.022973,0.0163014,-0.00369863
True,compatible,,True,True,True,,0,2,partial,0.1,0.1,0.2,,,52,not_established,not_triggered,,,ENSG00000126752,SSX1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,17,partial,29.3,17.4,40.9,"thymus: 40.9 nTPM (manageable, limit 5); bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 2); rectum: 6.5 nTPM (protected, limit 2); colon: 5.4 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000126787,DLGAP5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.2558% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 36.5801% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.6879% (minimum 99%, Baseline (adaptation disabled)); colon: 75.7848% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.5229% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.1689% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.8304% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8304% (minimum 99%, Baseline (adaptation disabled)); liver: 96.0227% (minimum 99%, Baseline (adaptation disabled)); lung: 96.0227% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.2711% (minimum 97%, Baseline (adaptation disabled)); rectum: 72.2222% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.0227% (minimum 97%, Baseline (adaptation disabled)); skin: 84.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.9720% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.3535% (minimum 97%, Baseline (adaptation disabled)); thymus: 29.2388% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 89.4180% (minimum 97%, Baseline (adaptation disabled))",0,17,partial,29.3,17.4,40.9,"thymus: 40.9 nTPM (manageable, limit 5); bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 2); rectum: 6.5 nTPM (protected, limit 2); colon: 5.4 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000126787,DLGAP5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.657612,-0.477289,-0.624199
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 36.5801% (minimum 99%, Missing); cerebral cortex: 97.6879% (minimum 99%, Missing); colon: 75.7848% (minimum 97%, Missing); duodenum: 77.5229% (minimum 99%, Missing); esophagus: 77.1689% (minimum 97%, Missing); kidney: 98.8304% (minimum 99%, Missing); lung: 96.0227% (minimum 99%, Missing); lymph node: 49.2711% (minimum 97%, Missing); rectum: 72.2222% (minimum 97%, Missing); skin: 84.5000% (minimum 95%, Missing); small intestine: 78.9720% (minimum 99%, Missing); smooth muscle: 86.6667% (minimum 99%, Missing); spleen: 86.6667% (minimum 95%, Missing); stomach: 85.3535% (minimum 97%, Missing); thymus: 29.2388% (minimum 95%, Missing); urinary bladder: 89.4180% (minimum 97%, Missing)",0,17,partial,29.3,17.4,40.9,"thymus: 40.9 nTPM (manageable, limit 5); bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 2); rectum: 6.5 nTPM (protected, limit 2); colon: 5.4 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000126787,DLGAP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.657612,-0.477289,-0.624199
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000126856,PRDM7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000126856,PRDM7,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000126856,PRDM7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,2,partial,5.1,0.8,2.9,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000126890,CTAG2,reproductive_required,False,True,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 92.6606% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.0583% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0583% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0583% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.1905% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.6606% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.4474% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.1154% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.1154% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.8148% (minimum 99%, Baseline (adaptation disabled)); liver: 94.3925% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0583% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.3925% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.1667% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1154% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 76.5152% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.0583% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1154% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.2830% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.6923% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,5.1,0.8,2.9,"heart muscle: 5.1 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000126890,CTAG2,current_fixed,False,True,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,-0.173077,-0.0433945,-0.325526
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 92.6606% (minimum 95%, Enhanced); amygdala: 98.0583% (minimum 99%, Missing); basal ganglia: 98.0583% (minimum 99%, Missing); heart muscle: 66.4474% (minimum 95%, Enhanced); hippocampal formation: 97.1154% (minimum 99%, Missing); hypothalamus: 97.1154% (minimum 99%, Missing); kidney: 74.8148% (minimum 95%, Enhanced); liver: 94.3925% (minimum 95%, Enhanced); midbrain: 94.3925% (minimum 99%, Missing); pancreas: 84.1667% (minimum 95%, Enhanced); pituitary gland: 97.1154% (minimum 99%, Missing); skeletal muscle: 76.5152% (minimum 95%, Enhanced); spinal cord: 97.1154% (minimum 99%, Missing); thymus: 77.6923% (minimum 95%, Missing)",0,2,partial,5.1,0.8,2.9,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000126890,CTAG2,current_adaptive,False,True,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,-0.173077,0.03,-0.285526
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,86.9,42.8,6.8,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 2); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127252,PLAAT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.7568% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.3883% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.7949% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.2102% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.3395% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.9127% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.8337% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.9127% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.3871% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.0941% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0822% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.0190% (minimum 99%, Baseline (adaptation disabled)); retina: 89.1656% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 45.1735% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.3516% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.7568% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 91.3265% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.5874% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,86.9,42.8,6.8,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 2); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127252,PLAAT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0367347,-0.344126,-0.538265
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.7568% (minimum 99%, Missing); amygdala: 89.3883% (minimum 99%, Missing); basal ganglia: 91.7949% (minimum 99%, Missing); cerebral cortex: 91.2102% (minimum 99%, Missing); choroid plexus: 95.3395% (minimum 99%, Missing); esophagus: 91.9127% (minimum 97%, Missing); heart muscle: 88.8337% (minimum 99%, Missing); hippocampal formation: 91.9127% (minimum 99%, Missing); hypothalamus: 92.3871% (minimum 99%, Missing); midbrain: 91.0941% (minimum 99%, Missing); pancreas: 98.0822% (minimum 99%, Missing); pituitary gland: 97.0190% (minimum 99%, Missing); retina: 89.1656% (minimum 99%, Missing); skeletal muscle: 45.1735% (minimum 99%, Missing); smooth muscle: 98.3516% (minimum 99%, Missing); spinal cord: 96.7568% (minimum 99%, Missing); thyroid gland: 91.3265% (minimum 95%, Missing); tongue: 62.5874% (minimum 97%, Missing)",0,80,unavailable,86.9,42.8,6.8,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 2); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127252,PLAAT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0367347,-0.344126,-0.538265
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,1.2,0.7,1.7,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127311,HELB,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 53.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.7273% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.7273% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 47.0588% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 53.3333% (minimum 97%, Baseline (adaptation disabled)); esophagus: 61.5385% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.7273% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.7273% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 40.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 44.4444% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.5385% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 50.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.8889% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 40.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 88.8889% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 61.5385% (minimum 95%, Baseline (adaptation disabled)); small intestine: 40.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.1429% (minimum 99%, Baseline (adaptation disabled)); spleen: 32.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 53.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.3333% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 61.5385% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.2,0.7,1.7,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127311,HELB,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.63,-0.436667,-0.59
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 53.3333% (minimum 95%, Missing); adrenal gland: 72.7273% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 72.7273% (minimum 99%, Missing); bone marrow: 47.0588% (minimum 99%, Missing); cerebral cortex: 80.0000% (minimum 99%, Missing); colon: 53.3333% (minimum 97%, Missing); esophagus: 61.5385% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 72.7273% (minimum 99%, Missing); hypothalamus: 72.7273% (minimum 99%, Missing); kidney: 53.3333% (minimum 99%, Missing); liver: 40.0000% (minimum 99%, Missing); lung: 44.4444% (minimum 99%, Missing); lymph node: 61.5385% (minimum 97%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 50.0000% (minimum 99%, Missing); parathyroid gland: 88.8889% (minimum 97%, Missing); pituitary gland: 40.0000% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 88.8889% (minimum 99%, Missing); salivary gland: 53.3333% (minimum 97%, Missing); skeletal muscle: 80.0000% (minimum 99%, Missing); skin: 61.5385% (minimum 95%, Missing); small intestine: 40.0000% (minimum 99%, Missing); smooth muscle: 88.8889% (minimum 99%, Missing); spinal cord: 57.1429% (minimum 99%, Missing); spleen: 32.0000% (minimum 95%, Missing); stomach: 53.3333% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 53.3333% (minimum 95%, Missing); urinary bladder: 61.5385% (minimum 97%, Missing)",0,80,unavailable,1.2,0.7,1.7,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127311,HELB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.63,-0.436667,-0.59
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,45.2,22,25.2,"bone marrow: 45.2 nTPM (vital, limit 1); thymus: 25.2 nTPM (manageable, limit 5); lymph node: 22 nTPM (protected, limit 2); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 2); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); rectum: 13.3 nTPM (protected, limit 2); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 2); salivary gland: 11.7 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 2); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.8 nTPM (protected, limit 2); stomach: 10.7 nTPM (protected, limit 2); heart muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127337,YEATS4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.8226% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.7895% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.5369% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.3571% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 44.3350% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.4411% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.2532% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.7269% (minimum 99%, Baseline (adaptation disabled)); colon: 75.1566% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.3198% (minimum 99%, Baseline (adaptation disabled)); esophagus: 76.1099% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.0878% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.8182% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.7746% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.8661% (minimum 99%, Baseline (adaptation disabled)); liver: 71.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 80.7175% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.0690% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.1782% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.1818% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 76.9231% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.4314% (minimum 99%, Baseline (adaptation disabled)); rectum: 73.0223% (minimum 97%, Baseline (adaptation disabled)); retina: 64.9819% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.4717% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 72.2892% (minimum 99%, Baseline (adaptation disabled)); skin: 76.5957% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.3198% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.6327% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.2609% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.0878% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.0878% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.8235% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 72.8745% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.8135% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.7591% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,45.2,22,25.2,"bone marrow: 45.2 nTPM (vital, limit 1); thymus: 25.2 nTPM (manageable, limit 5); lymph node: 22 nTPM (protected, limit 2); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 2); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); rectum: 13.3 nTPM (protected, limit 2); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 2); salivary gland: 11.7 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 2); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.8 nTPM (protected, limit 2); stomach: 10.7 nTPM (protected, limit 2); heart muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127337,YEATS4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.361765,-0.34931,-0.54665
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.8226% (minimum 95%, Missing); adrenal gland: 75.7895% (minimum 99%, Missing); amygdala: 80.5369% (minimum 99%, Missing); basal ganglia: 80.3571% (minimum 99%, Missing); bone marrow: 44.3350% (minimum 99%, Missing); cerebellum: 68.4411% (minimum 99%, Missing); cerebral cortex: 77.2532% (minimum 99%, Missing); choroid plexus: 70.7269% (minimum 99%, Missing); colon: 75.1566% (minimum 97%, Missing); duodenum: 73.3198% (minimum 99%, Missing); esophagus: 76.1099% (minimum 97%, Missing); heart muscle: 77.0878% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 78.7746% (minimum 99%, Missing); kidney: 70.8661% (minimum 99%, Missing); liver: 71.4286% (minimum 99%, Missing); lung: 80.7175% (minimum 99%, Missing); lymph node: 62.0690% (minimum 97%, Missing); midbrain: 80.1782% (minimum 99%, Missing); pancreas: 68.1818% (minimum 99%, Missing); parathyroid gland: 76.9231% (minimum 97%, Missing); pituitary gland: 78.4314% (minimum 99%, Missing); rectum: 73.0223% (minimum 97%, Missing); retina: 64.9819% (minimum 99%, Missing); salivary gland: 75.4717% (minimum 97%, Missing); skeletal muscle: 72.2892% (minimum 99%, Missing); skin: 76.5957% (minimum 95%, Missing); small intestine: 73.3198% (minimum 99%, Missing); smooth muscle: 81.6327% (minimum 99%, Missing); spinal cord: 78.2609% (minimum 99%, Missing); spleen: 77.0878% (minimum 95%, Missing); stomach: 77.0878% (minimum 97%, Missing); thymus: 58.8235% (minimum 95%, Missing); thyroid gland: 72.8745% (minimum 95%, Missing); tongue: 65.8135% (minimum 97%, Missing); urinary bladder: 76.7591% (minimum 97%, Missing)",0,80,unavailable,45.2,22,25.2,"bone marrow: 45.2 nTPM (vital, limit 1); thymus: 25.2 nTPM (manageable, limit 5); lymph node: 22 nTPM (protected, limit 2); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 2); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); rectum: 13.3 nTPM (protected, limit 2); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 2); salivary gland: 11.7 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 2); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.8 nTPM (protected, limit 2); stomach: 10.7 nTPM (protected, limit 2); heart muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127337,YEATS4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.361765,-0.34931,-0.54665
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.1,1.4,1.3,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127423,AUNIP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.5122% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.5122% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.8750% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 71.7593% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.3735% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.8144% (minimum 99%, Baseline (adaptation disabled)); colon: 95.6790% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.5122% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.7160% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.2733% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.6790% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.8750% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.4843% (minimum 99%, Baseline (adaptation disabled)); liver: 96.8750% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1013% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.8144% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.4843% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.7261% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.4843% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.0920% (minimum 97%, Baseline (adaptation disabled)); retina: 94.5122% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.2733% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.0920% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7261% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7261% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.8750% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.2619% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,6.1,1.4,1.3,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127423,AUNIP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.027381,-0.0528402,-0.272407
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.5122% (minimum 99%, Missing); amygdala: 94.5122% (minimum 99%, Missing); basal ganglia: 96.8750% (minimum 99%, Missing); bone marrow: 71.7593% (minimum 99%, Missing); cerebellum: 93.3735% (minimum 99%, Missing); cerebral cortex: 92.8144% (minimum 99%, Missing); colon: 95.6790% (minimum 97%, Missing); duodenum: 94.5122% (minimum 99%, Missing); esophagus: 91.7160% (minimum 97%, Missing); heart muscle: 96.2733% (minimum 99%, Missing); hippocampal formation: 95.6790% (minimum 99%, Missing); hypothalamus: 96.8750% (minimum 99%, Missing); kidney: 97.4843% (minimum 99%, Missing); liver: 96.8750% (minimum 99%, Missing); lung: 98.1013% (minimum 99%, Missing); lymph node: 92.8144% (minimum 97%, Missing); midbrain: 97.4843% (minimum 99%, Missing); pancreas: 98.7261% (minimum 99%, Missing); pituitary gland: 97.4843% (minimum 99%, Missing); rectum: 95.0920% (minimum 97%, Missing); retina: 94.5122% (minimum 99%, Missing); skeletal muscle: 96.2733% (minimum 99%, Missing); small intestine: 95.0920% (minimum 99%, Missing); smooth muscle: 98.7261% (minimum 99%, Missing); spinal cord: 98.7261% (minimum 99%, Missing); stomach: 96.8750% (minimum 97%, Missing); thymus: 92.2619% (minimum 95%, Missing)",0,80,unavailable,6.1,1.4,1.3,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127423,AUNIP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.027381,-0.0528402,-0.272407
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,301.2,105.5,68.8,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 2); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 2); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 2); esophagus: 69.6 nTPM (protected, limit 2); adipose tissue: 68.8 nTPM (manageable, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); spleen: 59.5 nTPM (manageable, limit 5); urinary bladder: 58.9 nTPM (protected, limit 2); duodenum: 57.9 nTPM (vital, limit 1); salivary gland: 52.3 nTPM (protected, limit 2); thyroid gland: 51 nTPM (manageable, limit 5); skin: 48.9 nTPM (manageable, limit 5); pancreas: 47.9 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 2); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 2); thymus: 23.4 nTPM (manageable, limit 5); rectum: 22 nTPM (protected, limit 2); smooth muscle: 21.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127540,UQCR11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.6253% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 43.6139% (minimum 99%, Baseline (adaptation disabled)); amygdala: 30.0650% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 34.7801% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.6458% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.0112% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 36.1178% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 38.6495% (minimum 99%, Baseline (adaptation disabled)); colon: 40.4169% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.9322% (minimum 99%, Baseline (adaptation disabled)); esophagus: 46.3377% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 17.2552% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 36.2923% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 41.8524% (minimum 99%, Baseline (adaptation disabled)); kidney: 37.3989% (minimum 99%, Baseline (adaptation disabled)); liver: 31.1238% (minimum 99%, Baseline (adaptation disabled)); lung: 56.0112% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.1600% (minimum 97%, Baseline (adaptation disabled)); midbrain: 31.8158% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.6481% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.1293% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 49.6284% (minimum 99%, Baseline (adaptation disabled)); rectum: 73.2034% (minimum 97%, Baseline (adaptation disabled)); retina: 81.8801% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.4698% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 16.6344% (minimum 99%, Baseline (adaptation disabled)); skin: 55.1376% (minimum 95%, Baseline (adaptation disabled)); small intestine: 49.7105% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.5618% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 40.3898% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.2508% (minimum 95%, Baseline (adaptation disabled)); stomach: 44.5185% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.9760% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.0954% (minimum 95%, Baseline (adaptation disabled)); tongue: 36.2923% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.5042% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,301.2,105.5,68.8,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 2); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 2); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 2); esophagus: 69.6 nTPM (protected, limit 2); adipose tissue: 68.8 nTPM (manageable, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); spleen: 59.5 nTPM (manageable, limit 5); urinary bladder: 58.9 nTPM (protected, limit 2); duodenum: 57.9 nTPM (vital, limit 1); salivary gland: 52.3 nTPM (protected, limit 2); thyroid gland: 51 nTPM (manageable, limit 5); skin: 48.9 nTPM (manageable, limit 5); pancreas: 47.9 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 2); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 2); thymus: 23.4 nTPM (manageable, limit 5); rectum: 22 nTPM (protected, limit 2); smooth muscle: 21.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127540,UQCR11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.483747,-0.607077,-0.823656
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.6253% (minimum 95%, Missing); adrenal gland: 43.6139% (minimum 99%, Missing); amygdala: 30.0650% (minimum 99%, Missing); basal ganglia: 34.7801% (minimum 99%, Missing); bone marrow: 60.6458% (minimum 99%, Missing); cerebellum: 56.0112% (minimum 99%, Missing); cerebral cortex: 36.1178% (minimum 99%, Missing); choroid plexus: 38.6495% (minimum 99%, Missing); colon: 40.4169% (minimum 97%, Missing); duodenum: 50.9322% (minimum 99%, Missing); esophagus: 46.3377% (minimum 97%, Missing); heart muscle: 17.2552% (minimum 99%, Missing); hippocampal formation: 36.2923% (minimum 99%, Missing); hypothalamus: 41.8524% (minimum 99%, Missing); kidney: 37.3989% (minimum 99%, Missing); liver: 31.1238% (minimum 99%, Missing); lung: 56.0112% (minimum 99%, Missing); lymph node: 69.1600% (minimum 97%, Missing); midbrain: 31.8158% (minimum 99%, Missing); pancreas: 55.6481% (minimum 99%, Missing); parathyroid gland: 57.1293% (minimum 97%, Missing); pituitary gland: 49.6284% (minimum 99%, Missing); rectum: 73.2034% (minimum 97%, Missing); retina: 81.8801% (minimum 99%, Missing); salivary gland: 53.4698% (minimum 97%, Missing); skeletal muscle: 16.6344% (minimum 99%, Missing); skin: 55.1376% (minimum 95%, Missing); small intestine: 49.7105% (minimum 99%, Missing); smooth muscle: 73.5618% (minimum 99%, Missing); spinal cord: 40.3898% (minimum 99%, Missing); spleen: 50.2508% (minimum 95%, Missing); stomach: 44.5185% (minimum 97%, Missing); thymus: 71.9760% (minimum 95%, Missing); thyroid gland: 54.0954% (minimum 95%, Missing); tongue: 36.2923% (minimum 97%, Missing); urinary bladder: 50.5042% (minimum 97%, Missing)",0,80,unavailable,301.2,105.5,68.8,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 2); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 2); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 2); esophagus: 69.6 nTPM (protected, limit 2); adipose tissue: 68.8 nTPM (manageable, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); spleen: 59.5 nTPM (manageable, limit 5); urinary bladder: 58.9 nTPM (protected, limit 2); duodenum: 57.9 nTPM (vital, limit 1); salivary gland: 52.3 nTPM (protected, limit 2); thyroid gland: 51 nTPM (manageable, limit 5); skin: 48.9 nTPM (manageable, limit 5); pancreas: 47.9 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 2); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 2); thymus: 23.4 nTPM (manageable, limit 5); rectum: 22 nTPM (protected, limit 2); smooth muscle: 21.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127540,UQCR11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.483747,-0.607077,-0.823656
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,27.3,11.2,9.3,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 2); thymus: 9.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127564,PKMYT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2238% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.0496% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.3986% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.9492% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.5702% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.7032% (minimum 99%, Baseline (adaptation disabled)); colon: 93.5702% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.3448% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.1579% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.5740% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.8761% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.0496% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.3986% (minimum 99%, Baseline (adaptation disabled)); liver: 97.1880% (minimum 99%, Baseline (adaptation disabled)); lung: 96.6783% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.6387% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.8761% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.0175% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.2238% (minimum 99%, Baseline (adaptation disabled)); retina: 76.5928% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.6783% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.0069% (minimum 99%, Baseline (adaptation disabled)); skin: 92.7852% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.4122% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.3986% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.8476% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.1038% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.5299% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.6037% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,27.3,11.2,9.3,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 2); thymus: 9.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127564,PKMYT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0939628,-0.138421,-0.320508
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2238% (minimum 99%, Missing); amygdala: 98.0496% (minimum 99%, Missing); basal ganglia: 98.3986% (minimum 99%, Missing); bone marrow: 66.9492% (minimum 99%, Missing); cerebellum: 93.5702% (minimum 99%, Missing); cerebral cortex: 97.7032% (minimum 99%, Missing); colon: 93.5702% (minimum 97%, Missing); duodenum: 95.3448% (minimum 99%, Missing); esophagus: 83.1579% (minimum 97%, Missing); heart muscle: 98.5740% (minimum 99%, Missing); hippocampal formation: 97.8761% (minimum 99%, Missing); hypothalamus: 98.0496% (minimum 99%, Missing); kidney: 98.3986% (minimum 99%, Missing); liver: 97.1880% (minimum 99%, Missing); lung: 96.6783% (minimum 99%, Missing); lymph node: 87.6387% (minimum 97%, Missing); midbrain: 97.8761% (minimum 99%, Missing); pancreas: 97.0175% (minimum 99%, Missing); pituitary gland: 98.2238% (minimum 99%, Missing); retina: 76.5928% (minimum 99%, Missing); salivary gland: 96.6783% (minimum 97%, Missing); skeletal muscle: 96.0069% (minimum 99%, Missing); skin: 92.7852% (minimum 95%, Missing); small intestine: 93.4122% (minimum 99%, Missing); smooth muscle: 98.3986% (minimum 99%, Missing); spinal cord: 96.8476% (minimum 99%, Missing); spleen: 91.1038% (minimum 95%, Missing); stomach: 94.5299% (minimum 97%, Missing); thymus: 85.6037% (minimum 95%, Missing)",0,80,unavailable,27.3,11.2,9.3,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 2); thymus: 9.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); spleen: 5.4 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000127564,PKMYT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0939628,-0.138421,-0.320508
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,32.1,21.9,24.6,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); thymus: 24.6 nTPM (manageable, limit 5); lymph node: 21.9 nTPM (protected, limit 4); parathyroid gland: 21.6 nTPM (protected, limit 2); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 2); spleen: 19.2 nTPM (manageable, limit 5); adipose tissue: 18.3 nTPM (manageable, limit 10); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 2); esophagus: 17.9 nTPM (protected, limit 4); rectum: 17.9 nTPM (protected, limit 2); colon: 17.8 nTPM (protected, limit 2); urinary bladder: 17.7 nTPM (protected, limit 2); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); thyroid gland: 16.9 nTPM (manageable, limit 10); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 2); liver: 16.1 nTPM (vital, limit 2); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 2); tongue: 14.7 nTPM (protected, limit 2); pancreas: 13.7 nTPM (vital, limit 2); amygdala: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 2); salivary gland: 13.1 nTPM (protected, limit 4); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000127870,RNF6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.0472% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.9919% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.5628% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.7258% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 50.3864% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.5545% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.2588% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.9907% (minimum 99%, Baseline (adaptation disabled)); colon: 64.6825% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.7258% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.5545% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.1790% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.0240% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.9229% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.9402% (minimum 99%, Baseline (adaptation disabled)); liver: 66.9405% (minimum 99%, Baseline (adaptation disabled)); lung: 67.4948% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.8165% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.9907% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.4104% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.1476% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.6381% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.5545% (minimum 97%, Baseline (adaptation disabled)); retina: 55.8219% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.3348% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.5094% (minimum 99%, Baseline (adaptation disabled)); skin: 65.8586% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.0472% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.3438% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.5542% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.9344% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.1258% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.9930% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.8586% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.9218% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.8111% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,32.1,21.9,24.6,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); thymus: 24.6 nTPM (manageable, limit 5); lymph node: 21.9 nTPM (protected, limit 2); parathyroid gland: 21.6 nTPM (protected, limit 2); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 1); spleen: 19.2 nTPM (manageable, limit 5); adipose tissue: 18.3 nTPM (manageable, limit 5); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 2); rectum: 17.9 nTPM (protected, limit 2); colon: 17.8 nTPM (protected, limit 2); urinary bladder: 17.7 nTPM (protected, limit 2); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); thyroid gland: 16.9 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 2); liver: 16.1 nTPM (vital, limit 1); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 2); pancreas: 13.7 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 2); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000127870,RNF6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.38007,-0.371835,-0.486136
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.0472% (minimum 90%, Approved); adrenal gland: 65.9919% (minimum 99%, Missing); amygdala: 70.5628% (minimum 99%, Missing); basal ganglia: 65.7258% (minimum 99%, Missing); bone marrow: 50.3864% (minimum 99%, Missing); cerebellum: 64.5545% (minimum 98%, Approved); cerebral cortex: 60.2588% (minimum 99%, Missing); choroid plexus: 75.9907% (minimum 99%, Missing); colon: 64.6825% (minimum 97%, Missing); duodenum: 65.7258% (minimum 99%, Missing); esophagus: 64.5545% (minimum 95%, Approved); heart muscle: 71.1790% (minimum 98%, Approved); hippocampal formation: 71.0240% (minimum 99%, Missing); hypothalamus: 73.9229% (minimum 99%, Missing); kidney: 64.9402% (minimum 99%, Missing); liver: 66.9405% (minimum 98%, Approved); lung: 67.4948% (minimum 99%, Missing); lymph node: 59.8165% (minimum 95%, Approved); midbrain: 75.9907% (minimum 99%, Missing); pancreas: 70.4104% (minimum 98%, Approved); parathyroid gland: 60.1476% (minimum 97%, Missing); pituitary gland: 75.6381% (minimum 99%, Missing); rectum: 64.5545% (minimum 97%, Missing); retina: 55.8219% (minimum 99%, Missing); salivary gland: 71.3348% (minimum 95%, Approved); skeletal muscle: 61.5094% (minimum 98%, Approved); skin: 65.8586% (minimum 95%, Missing); small intestine: 64.0472% (minimum 99%, Missing); smooth muscle: 68.3438% (minimum 98%, Approved); spinal cord: 78.5542% (minimum 99%, Missing); spleen: 62.9344% (minimum 95%, Missing); stomach: 66.1258% (minimum 97%, Missing); thymus: 56.9930% (minimum 95%, Missing); thyroid gland: 65.8586% (minimum 90%, Approved); tongue: 68.9218% (minimum 97%, Missing); urinary bladder: 64.8111% (minimum 97%, Missing)",0,3,partial,32.1,21.9,24.6,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); thymus: 24.6 nTPM (manageable, limit 5); lymph node: 21.9 nTPM (protected, limit 4); parathyroid gland: 21.6 nTPM (protected, limit 2); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 2); spleen: 19.2 nTPM (manageable, limit 5); adipose tissue: 18.3 nTPM (manageable, limit 10); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 2); esophagus: 17.9 nTPM (protected, limit 4); rectum: 17.9 nTPM (protected, limit 2); colon: 17.8 nTPM (protected, limit 2); urinary bladder: 17.7 nTPM (protected, limit 2); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); thyroid gland: 16.9 nTPM (manageable, limit 10); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 2); liver: 16.1 nTPM (vital, limit 2); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 2); tongue: 14.7 nTPM (protected, limit 2); pancreas: 13.7 nTPM (vital, limit 2); amygdala: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 2); salivary gland: 13.1 nTPM (protected, limit 4); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000127870,RNF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.38007,-0.368524,-0.486136
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,1842.8,0.4,0.1,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000127928,GNGT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 20.1439% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.3226% (minimum 99%, Baseline (adaptation disabled)); retina: 0.1517% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.5000% (minimum 97%, Baseline (adaptation disabled)); stomach: 96.5517% (minimum 97%, Baseline (adaptation disabled)); tongue: 96.5517% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.3226% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,1842.8,0.4,0.1,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000127928,GNGT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0155172,-0.095,-0.988483
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 20.1439% (minimum 99%, Missing); heart muscle: 93.3333% (minimum 95%, Enhanced); kidney: 90.3226% (minimum 95%, Enhanced); retina: 0.1517% (minimum 99%, Missing); tongue: 96.5517% (minimum 97%, Missing)",0,0,routine_complete,1842.8,0.4,0.1,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000127928,GNGT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0155172,-0.00448276,-0.988483
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,14.1,8.2,11.1,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); spleen: 11.1 nTPM (manageable, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); pancreas: 8.2 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 2); thyroid gland: 8.1 nTPM (manageable, limit 5); salivary gland: 8.1 nTPM (protected, limit 2); adipose tissue: 8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); colon: 7.8 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 2); tongue: 6.7 nTPM (protected, limit 2); thymus: 6.4 nTPM (manageable, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000127993,RBM48,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0230% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 53.1073% (minimum 99%, Baseline (adaptation disabled)); amygdala: 48.9583% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 44.1315% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 40.5172% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 40.1709% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 41.9643% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.6259% (minimum 99%, Baseline (adaptation disabled)); colon: 54.6512% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.3836% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.9524% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 49.2147% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 43.1193% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 45.8537% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.6265% (minimum 99%, Baseline (adaptation disabled)); liver: 51.6484% (minimum 99%, Baseline (adaptation disabled)); lung: 60.2564% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.4091% (minimum 97%, Baseline (adaptation disabled)); midbrain: 42.9224% (minimum 99%, Baseline (adaptation disabled)); pancreas: 53.4091% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 67.6259% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.2874% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.6259% (minimum 97%, Baseline (adaptation disabled)); retina: 59.8726% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.7143% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 41.9643% (minimum 99%, Baseline (adaptation disabled)); skin: 54.6512% (minimum 95%, Baseline (adaptation disabled)); small intestine: 51.9337% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.8682% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 40.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 45.8537% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.9708% (minimum 97%, Baseline (adaptation disabled)); thymus: 59.4937% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.7143% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.3851% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.9697% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,14.1,8.2,11.1,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); spleen: 11.1 nTPM (manageable, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); pancreas: 8.2 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 2); thyroid gland: 8.1 nTPM (manageable, limit 5); salivary gland: 8.1 nTPM (protected, limit 2); adipose tissue: 8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); colon: 7.8 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 2); tongue: 6.7 nTPM (protected, limit 2); thymus: 6.4 nTPM (manageable, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000127993,RBM48,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.491463,-0.435909,-0.59
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0230% (minimum 95%, Uncertain); adrenal gland: 53.1073% (minimum 99%, Missing); amygdala: 48.9583% (minimum 99%, Missing); basal ganglia: 44.1315% (minimum 99%, Missing); bone marrow: 40.5172% (minimum 99%, Missing); cerebellum: 40.1709% (minimum 99%, Missing); cerebral cortex: 41.9643% (minimum 99%, Missing); choroid plexus: 67.6259% (minimum 99%, Missing); colon: 54.6512% (minimum 97%, Missing); duodenum: 64.3836% (minimum 99%, Missing); esophagus: 55.9524% (minimum 97%, Missing); heart muscle: 49.2147% (minimum 99%, Missing); hippocampal formation: 43.1193% (minimum 99%, Missing); hypothalamus: 45.8537% (minimum 99%, Missing); kidney: 56.6265% (minimum 99%, Missing); liver: 51.6484% (minimum 99%, Missing); lung: 60.2564% (minimum 99%, Missing); lymph node: 53.4091% (minimum 97%, Missing); midbrain: 42.9224% (minimum 99%, Missing); pancreas: 53.4091% (minimum 99%, Missing); parathyroid gland: 67.6259% (minimum 97%, Missing); pituitary gland: 56.2874% (minimum 99%, Missing); rectum: 67.6259% (minimum 97%, Missing); retina: 59.8726% (minimum 99%, Missing); salivary gland: 53.7143% (minimum 97%, Missing); skeletal muscle: 41.9643% (minimum 99%, Missing); skin: 54.6512% (minimum 95%, Missing); small intestine: 51.9337% (minimum 99%, Missing); smooth muscle: 72.8682% (minimum 99%, Missing); spinal cord: 40.0000% (minimum 99%, Missing); spleen: 45.8537% (minimum 95%, Missing); stomach: 54.9708% (minimum 97%, Missing); thymus: 59.4937% (minimum 95%, Missing); thyroid gland: 53.7143% (minimum 95%, Missing); tongue: 58.3851% (minimum 97%, Missing); urinary bladder: 56.9697% (minimum 97%, Missing)",0,1,partial,14.1,8.2,11.1,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); spleen: 11.1 nTPM (manageable, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); pancreas: 8.2 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 2); thyroid gland: 8.1 nTPM (manageable, limit 5); salivary gland: 8.1 nTPM (protected, limit 2); adipose tissue: 8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); colon: 7.8 nTPM (protected, limit 2); stomach: 7.7 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 2); tongue: 6.7 nTPM (protected, limit 2); thymus: 6.4 nTPM (manageable, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000127993,RBM48,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.491463,-0.435909,-0.59
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,13.1,4.6,3.8,"bone marrow: 13.1 nTPM (vital, limit 6); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 6); pituitary gland: 4 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128040,SPINK2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,13.1,4.6,3.8,"bone marrow: 13.1 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 2); pituitary gland: 4 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); tongue: 2.2 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128040,SPINK2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0492589,0.0291031,0.00744987
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,13.1,4.6,3.8,"bone marrow: 13.1 nTPM (vital, limit 6); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 6); pituitary gland: 4 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128040,SPINK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0492589,0.0295708,0.00818826
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,6,8.2,8.1,"lymph node: 8.2 nTPM (protected, limit 2); thymus: 8.1 nTPM (manageable, limit 5); urinary bladder: 6.5 nTPM (protected, limit 4); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); kidney: 5.8 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); bone marrow: 5.5 nTPM (vital, limit 2); cerebral cortex: 5.5 nTPM (vital, limit 1); rectum: 4.6 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); colon: 3.8 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 2); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); skeletal muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000128059,PPAT,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.6757% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.7413% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.7949% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.1864% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.4317% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.8525% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.4317% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.5882% (minimum 99%, Baseline (adaptation disabled)); colon: 68.8525% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.2927% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.1417% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.2453% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.6842% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.1864% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.1549% (minimum 99%, Baseline (adaptation disabled)); liver: 58.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.6024% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.5882% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.5745% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.8525% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.7778% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.6154% (minimum 97%, Baseline (adaptation disabled)); retina: 66.1417% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.4317% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 66.1417% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.0435% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.5882% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.6757% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.5882% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.9091% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.1549% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.3758% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,6,8.2,8.1,"lymph node: 8.2 nTPM (protected, limit 2); thymus: 8.1 nTPM (manageable, limit 5); urinary bladder: 6.5 nTPM (protected, limit 2); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); kidney: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); colon: 3.8 nTPM (protected, limit 2); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.8 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000128059,PPAT,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.440909,-0.463976,-0.406667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.6757% (minimum 95%, Missing); adrenal gland: 58.7413% (minimum 99%, Missing); amygdala: 71.7949% (minimum 99%, Missing); basal ganglia: 71.1864% (minimum 99%, Missing); bone marrow: 60.4317% (minimum 98%, Approved); cerebellum: 68.8525% (minimum 98%, Approved); cerebral cortex: 60.4317% (minimum 99%, Missing); choroid plexus: 70.5882% (minimum 99%, Missing); colon: 68.8525% (minimum 97%, Missing); duodenum: 68.2927% (minimum 99%, Missing); esophagus: 66.1417% (minimum 97%, Missing); heart muscle: 79.2453% (minimum 99%, Missing); hippocampal formation: 73.6842% (minimum 99%, Missing); hypothalamus: 71.1864% (minimum 99%, Missing); kidney: 59.1549% (minimum 99%, Missing); liver: 58.3333% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 50.6024% (minimum 97%, Missing); midbrain: 70.5882% (minimum 99%, Missing); pancreas: 59.5745% (minimum 99%, Missing); parathyroid gland: 68.8525% (minimum 95%, Approved); pituitary gland: 77.7778% (minimum 99%, Missing); rectum: 64.6154% (minimum 97%, Missing); retina: 66.1417% (minimum 99%, Missing); salivary gland: 60.4317% (minimum 97%, Missing); skeletal muscle: 75.0000% (minimum 99%, Missing); skin: 66.1417% (minimum 90%, Approved); small intestine: 73.0435% (minimum 99%, Missing); smooth muscle: 70.5882% (minimum 98%, Approved); spinal cord: 75.6757% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 70.5882% (minimum 97%, Missing); thymus: 50.9091% (minimum 95%, Missing); thyroid gland: 59.1549% (minimum 90%, Approved); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 56.3758% (minimum 95%, Approved)",0,3,partial,6,8.2,8.1,"lymph node: 8.2 nTPM (protected, limit 2); thymus: 8.1 nTPM (manageable, limit 5); urinary bladder: 6.5 nTPM (protected, limit 4); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); kidney: 5.8 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); bone marrow: 5.5 nTPM (vital, limit 2); cerebral cortex: 5.5 nTPM (vital, limit 1); rectum: 4.6 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); colon: 3.8 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 2); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); skeletal muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000128059,PPAT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.440909,-0.463976,-0.406667
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,15,partial,111,20,52.7,"basal ganglia: 111 nTPM (vital, limit 1); thymus: 52.7 nTPM (manageable, limit 5); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 2); kidney: 16.9 nTPM (vital, limit 1); liver: 14.2 nTPM (vital, limit 6); lung: 14.1 nTPM (vital, limit 6); heart muscle: 13.1 nTPM (vital, limit 6); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 6); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),94,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / non-germinal center cells,ENSG00000128271,ADORA2A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6279% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 50.4762% (minimum 99%, Baseline (adaptation disabled)); amygdala: 43.8017% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 4.5572% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 11.6740% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 35.0993% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 40.7692% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.6111% (minimum 99%, Baseline (adaptation disabled)); colon: 56.9892% (minimum 97%, Baseline (adaptation disabled)); duodenum: 45.2991% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.6111% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 28.8043% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 39.5522% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 42.7419% (minimum 99%, Baseline (adaptation disabled)); kidney: 23.8739% (minimum 99%, Baseline (adaptation disabled)); liver: 27.1795% (minimum 99%, Baseline (adaptation disabled)); lung: 27.3196% (minimum 99%, Baseline (adaptation disabled)); lymph node: 20.9486% (minimum 97%, Baseline (adaptation disabled)); midbrain: 41.4062% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.3636% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 44.9153% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.1270% (minimum 97%, Baseline (adaptation disabled)); retina: 72.6027% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.0952% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.8312% (minimum 99%, Baseline (adaptation disabled)); skin: 77.9412% (minimum 95%, Baseline (adaptation disabled)); small intestine: 43.8017% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.4839% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 54.0816% (minimum 99%, Baseline (adaptation disabled)); spleen: 26.3682% (minimum 95%, Baseline (adaptation disabled)); stomach: 58.2418% (minimum 97%, Baseline (adaptation disabled)); thymus: 9.1379% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.7895% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.3030% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.9615% (minimum 97%, Baseline (adaptation disabled))",0,15,partial,111,20,52.7,"basal ganglia: 111 nTPM (vital, limit 1); thymus: 52.7 nTPM (manageable, limit 5); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 2); kidney: 16.9 nTPM (vital, limit 1); spleen: 14.8 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); stomach: 3.8 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),94,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / non-germinal center cells,ENSG00000128271,ADORA2A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.858621,-0.760514,-0.944428
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.4762% (minimum 95%, Enhanced); amygdala: 43.8017% (minimum 99%, Missing); basal ganglia: 4.5572% (minimum 99%, Missing); bone marrow: 11.6740% (minimum 99%, Missing); cerebellum: 35.0993% (minimum 99%, Missing); cerebral cortex: 40.7692% (minimum 95%, Enhanced); choroid plexus: 73.6111% (minimum 99%, Missing); colon: 56.9892% (minimum 97%, Missing); duodenum: 45.2991% (minimum 99%, Missing); esophagus: 73.6111% (minimum 80%, Enhanced); heart muscle: 28.8043% (minimum 95%, Enhanced); hippocampal formation: 39.5522% (minimum 99%, Missing); hypothalamus: 42.7419% (minimum 99%, Missing); kidney: 23.8739% (minimum 99%, Missing); liver: 27.1795% (minimum 95%, Enhanced); lung: 27.3196% (minimum 95%, Enhanced); lymph node: 20.9486% (minimum 97%, Missing); midbrain: 41.4062% (minimum 99%, Missing); pancreas: 70.6667% (minimum 95%, Enhanced); pituitary gland: 44.9153% (minimum 99%, Missing); rectum: 84.1270% (minimum 97%, Missing); retina: 72.6027% (minimum 99%, Missing); salivary gland: 63.0952% (minimum 80%, Enhanced); skeletal muscle: 68.8312% (minimum 95%, Enhanced); small intestine: 43.8017% (minimum 99%, Missing); smooth muscle: 85.4839% (minimum 95%, Enhanced); spinal cord: 54.0816% (minimum 99%, Missing); spleen: 26.3682% (minimum 60%, Enhanced); stomach: 58.2418% (minimum 80%, Enhanced); thymus: 9.1379% (minimum 95%, Missing); thyroid gland: 55.7895% (minimum 60%, Enhanced); tongue: 80.3030% (minimum 97%, Missing); urinary bladder: 50.9615% (minimum 80%, Enhanced)",0,15,partial,111,20,52.7,"basal ganglia: 111 nTPM (vital, limit 1); thymus: 52.7 nTPM (manageable, limit 5); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 2); kidney: 16.9 nTPM (vital, limit 1); liver: 14.2 nTPM (vital, limit 6); lung: 14.1 nTPM (vital, limit 6); heart muscle: 13.1 nTPM (vital, limit 6); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 6); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),94,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / non-germinal center cells,ENSG00000128271,ADORA2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.858621,-0.760514,-0.944428
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,69.3,1.6,9.9,"bone marrow: 69.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000128322,IGLL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 26.1194% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.7903% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.8697% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.2209% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,69.3,1.6,9.9,"bone marrow: 69.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000128322,IGLL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,-0.237791,-0.0313027,-0.728806
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 26.1194% (minimum 99%, Missing); thymus: 71.2209% (minimum 95%, Missing)",0,2,partial,69.3,1.6,9.9,"bone marrow: 69.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000128322,IGLL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,-0.237791,0.03,-0.728806
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.8,13.5,25.2,"skin: 25.2 nTPM (manageable, limit 5); esophagus: 13.5 nTPM (protected, limit 2); choroid plexus: 10.8 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); skeletal muscle: 5.5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); retina: 3.4 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); bone marrow: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000128346,C22orf23,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.3767% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.9937% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.6842% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.8685% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6185% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.8000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.5753% (minimum 99%, Baseline (adaptation disabled)); colon: 96.5661% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.0711% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.3001% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.8875% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6842% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.0711% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.6842% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0820% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.3655% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.8903% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.7903% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.1795% (minimum 99%, Baseline (adaptation disabled)); retina: 96.4657% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.2724% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.4049% (minimum 99%, Baseline (adaptation disabled)); skin: 78.6441% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.1658% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.2746% (minimum 99%, Baseline (adaptation disabled)); stomach: 91.4286% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.0635% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.9271% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.8,13.5,25.2,"skin: 25.2 nTPM (manageable, limit 5); esophagus: 13.5 nTPM (protected, limit 2); choroid plexus: 10.8 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); skeletal muscle: 5.5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); retina: 3.4 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); bone marrow: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000128346,C22orf23,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.163559,-0.0969991,-0.0942471
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.3767% (minimum 99%, Missing); amygdala: 97.9937% (minimum 99%, Missing); basal ganglia: 97.6842% (minimum 99%, Missing); bone marrow: 96.8685% (minimum 99%, Missing); cerebellum: 98.6185% (minimum 99%, Missing); cerebral cortex: 92.8000% (minimum 99%, Missing); choroid plexus: 89.5753% (minimum 99%, Missing); colon: 96.5661% (minimum 97%, Missing); duodenum: 97.0711% (minimum 99%, Missing); esophagus: 87.3001% (minimum 97%, Missing); heart muscle: 94.8875% (minimum 99%, Missing); hippocampal formation: 97.6842% (minimum 99%, Missing); hypothalamus: 97.0711% (minimum 99%, Missing); kidney: 97.6842% (minimum 99%, Missing); lung: 95.0820% (minimum 99%, Missing); lymph node: 96.3655% (minimum 97%, Missing); midbrain: 97.8903% (minimum 99%, Missing); pancreas: 91.7903% (minimum 99%, Missing); pituitary gland: 95.1795% (minimum 99%, Missing); retina: 96.4657% (minimum 99%, Missing); salivary gland: 90.2724% (minimum 97%, Missing); skeletal muscle: 94.4049% (minimum 99%, Missing); skin: 78.6441% (minimum 95%, Missing); small intestine: 96.1658% (minimum 99%, Missing); spinal cord: 97.2746% (minimum 99%, Missing); stomach: 91.4286% (minimum 97%, Missing); thyroid gland: 92.0635% (minimum 95%, Missing); urinary bladder: 93.9271% (minimum 97%, Missing)",0,80,unavailable,10.8,13.5,25.2,"skin: 25.2 nTPM (manageable, limit 5); esophagus: 13.5 nTPM (protected, limit 2); choroid plexus: 10.8 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); skeletal muscle: 5.5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); retina: 3.4 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); bone marrow: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000128346,C22orf23,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.163559,-0.0969991,-0.0942471
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.1,15.2,11.6,"lymph node: 15.2 nTPM (protected, limit 2); spleen: 11.6 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); parathyroid gland: 5 nTPM (protected, limit 2); salivary gland: 4.7 nTPM (protected, limit 2); stomach: 4.6 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); pituitary gland: 3.3 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128394,APOBEC3F,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.3738% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.5034% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.7551% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.6598% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.5043% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.6292% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.4894% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 59.3103% (minimum 99%, Baseline (adaptation disabled)); colon: 72.2689% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.0744% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.8991% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.8705% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.5833% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.7551% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.2689% (minimum 99%, Baseline (adaptation disabled)); liver: 75.4386% (minimum 99%, Baseline (adaptation disabled)); lung: 72.2689% (minimum 99%, Baseline (adaptation disabled)); lymph node: 36.1345% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.8687% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.7826% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.2353% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.2689% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.1062% (minimum 97%, Baseline (adaptation disabled)); retina: 88.6598% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.6617% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.4783% (minimum 99%, Baseline (adaptation disabled)); skin: 84.3137% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.9187% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.7551% (minimum 99%, Baseline (adaptation disabled)); spleen: 42.5743% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.1515% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.3188% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 74.7826% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.8687% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.1538% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.1,15.2,11.6,"lymph node: 15.2 nTPM (protected, limit 2); spleen: 11.6 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); parathyroid gland: 5 nTPM (protected, limit 2); salivary gland: 4.7 nTPM (protected, limit 2); stomach: 4.6 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); pituitary gland: 3.3 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128394,APOBEC3F,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.524257,-0.608655,-0.404966
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.3738% (minimum 95%, Missing); adrenal gland: 58.5034% (minimum 99%, Missing); amygdala: 87.7551% (minimum 99%, Missing); basal ganglia: 88.6598% (minimum 99%, Missing); bone marrow: 73.5043% (minimum 99%, Missing); cerebellum: 96.6292% (minimum 99%, Missing); cerebral cortex: 91.4894% (minimum 99%, Missing); choroid plexus: 59.3103% (minimum 99%, Missing); colon: 72.2689% (minimum 97%, Missing); duodenum: 71.0744% (minimum 99%, Missing); esophagus: 78.8991% (minimum 97%, Missing); heart muscle: 61.8705% (minimum 99%, Missing); hippocampal formation: 89.5833% (minimum 99%, Missing); hypothalamus: 87.7551% (minimum 99%, Missing); kidney: 72.2689% (minimum 99%, Missing); liver: 75.4386% (minimum 99%, Missing); lung: 72.2689% (minimum 99%, Missing); lymph node: 36.1345% (minimum 97%, Missing); midbrain: 86.8687% (minimum 99%, Missing); pancreas: 74.7826% (minimum 99%, Missing); parathyroid gland: 63.2353% (minimum 97%, Missing); pituitary gland: 72.2689% (minimum 99%, Missing); rectum: 76.1062% (minimum 97%, Missing); retina: 88.6598% (minimum 99%, Missing); salivary gland: 64.6617% (minimum 97%, Missing); skeletal muscle: 93.4783% (minimum 99%, Missing); skin: 84.3137% (minimum 95%, Missing); small intestine: 69.9187% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 87.7551% (minimum 99%, Missing); spleen: 42.5743% (minimum 95%, Missing); stomach: 65.1515% (minimum 97%, Missing); thymus: 62.3188% (minimum 95%, Missing); thyroid gland: 74.7826% (minimum 95%, Missing); tongue: 86.8687% (minimum 97%, Missing); urinary bladder: 66.1538% (minimum 97%, Missing)",0,80,unavailable,6.1,15.2,11.6,"lymph node: 15.2 nTPM (protected, limit 2); spleen: 11.6 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); parathyroid gland: 5 nTPM (protected, limit 2); salivary gland: 4.7 nTPM (protected, limit 2); stomach: 4.6 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); pituitary gland: 3.3 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128394,APOBEC3F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.524257,-0.608655,-0.404966
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,11,partial,13,1.2,0.9,"choroid plexus: 13 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128408,RIBC2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.7049% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.8199% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.0063% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.6262% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.4401% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.8199% (minimum 99%, Baseline (adaptation disabled)); lung: 97.3856% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.1290% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.5128% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.3498% (minimum 99%, Baseline (adaptation disabled))",0,11,partial,13,1.2,0.9,"choroid plexus: 13 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128408,RIBC2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,0.020684,-0.00870968,-0.293738
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.7049% (minimum 99%, Missing); basal ganglia: 95.8199% (minimum 99%, Missing); bone marrow: 94.0063% (minimum 98%, Approved); choroid plexus: 69.6262% (minimum 99%, Missing); hippocampal formation: 96.4401% (minimum 99%, Missing); hypothalamus: 95.8199% (minimum 99%, Missing); lung: 97.3856% (minimum 98%, Approved); pituitary gland: 95.5128% (minimum 99%, Missing)",0,11,partial,13,1.2,0.9,"choroid plexus: 13 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128408,RIBC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,0.0334983,0.0112903,-0.293738
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,36.2,14.5,13,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 2); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 2); pituitary gland: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 2); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); tongue: 2.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000128487,SPECC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7230% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.4762% (minimum 99%, Baseline (adaptation disabled)); amygdala: 51.0345% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 52.4823% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.2239% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.2727% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.2262% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 38.0137% (minimum 99%, Baseline (adaptation disabled)); colon: 60.4905% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.0315% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.3826% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.9188% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 46.3466% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.8358% (minimum 99%, Baseline (adaptation disabled)); liver: 95.2790% (minimum 99%, Baseline (adaptation disabled)); lung: 79.8561% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.3187% (minimum 97%, Baseline (adaptation disabled)); midbrain: 44.8485% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.8358% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.4462% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.1690% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.2532% (minimum 97%, Baseline (adaptation disabled)); retina: 79.5699% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.7234% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.2222% (minimum 99%, Baseline (adaptation disabled)); skin: 86.3813% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.7307% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.1538% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 38.4749% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.0682% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.9441% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.4462% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.6176% (minimum 95%, Baseline (adaptation disabled)); tongue: 89.5161% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.4586% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,36.2,14.5,13,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 2); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 2); pituitary gland: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 2); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); heart muscle: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); tongue: 2.6 nTPM (protected, limit 2); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000128487,SPECC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.319318,-0.365095,-0.609863
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7230% (minimum 95%, Missing); adrenal gland: 70.4762% (minimum 99%, Missing); amygdala: 51.0345% (minimum 99%, Missing); basal ganglia: 52.4823% (minimum 99%, Missing); bone marrow: 49.2239% (minimum 99%, Missing); cerebellum: 67.2727% (minimum 99%, Missing); cerebral cortex: 50.2262% (minimum 99%, Missing); choroid plexus: 38.0137% (minimum 99%, Missing); colon: 60.4905% (minimum 97%, Missing); duodenum: 70.0315% (minimum 99%, Missing); esophagus: 71.3826% (minimum 97%, Missing); heart muscle: 81.9188% (minimum 95%, Enhanced); hippocampal formation: 46.3466% (minimum 99%, Missing); hypothalamus: 55.5000% (minimum 99%, Missing); kidney: 82.8358% (minimum 99%, Missing); lung: 79.8561% (minimum 99%, Missing); lymph node: 81.3187% (minimum 97%, Missing); midbrain: 44.8485% (minimum 99%, Missing); pancreas: 82.8358% (minimum 99%, Missing); parathyroid gland: 88.4462% (minimum 97%, Missing); pituitary gland: 78.1690% (minimum 99%, Missing); rectum: 70.2532% (minimum 97%, Missing); retina: 79.5699% (minimum 99%, Missing); salivary gland: 78.7234% (minimum 97%, Missing); skeletal muscle: 82.2222% (minimum 99%, Missing); skin: 86.3813% (minimum 95%, Missing); small intestine: 68.7307% (minimum 99%, Missing); smooth muscle: 71.1538% (minimum 99%, Missing); spinal cord: 38.4749% (minimum 99%, Missing); spleen: 63.0682% (minimum 95%, Missing); stomach: 68.9441% (minimum 97%, Missing); thymus: 88.4462% (minimum 95%, Missing); thyroid gland: 81.6176% (minimum 95%, Missing); tongue: 89.5161% (minimum 97%, Missing); urinary bladder: 83.4586% (minimum 97%, Missing)",0,6,partial,36.2,14.5,13,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 2); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 2); pituitary gland: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 2); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); tongue: 2.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000128487,SPECC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.319318,-0.365095,-0.609863
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,85.4,19.5,5.1,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 12); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 12); smooth muscle: 11.2 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128596,CCDC136,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.0445% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.0299% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.7035% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.8827% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.1361% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.4096% (minimum 99%, Baseline (adaptation disabled)); colon: 90.2500% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.0430% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.8706% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.6206% (minimum 99%, Baseline (adaptation disabled)); midbrain: 84.1492% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.6274% (minimum 99%, Baseline (adaptation disabled)); retina: 78.0035% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.7260% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.4622% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.1575% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.4762% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 93.4265% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,85.4,19.5,5.1,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 2); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); heart muscle: 5.5 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); lymph node: 2.6 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128596,CCDC136,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0225216,-0.0675,-0.311173
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 87.0299% (minimum 99%, Missing); basal ganglia: 90.7035% (minimum 99%, Missing); cerebellum: 67.8827% (minimum 99%, Missing); cerebral cortex: 73.1361% (minimum 99%, Missing); choroid plexus: 97.4096% (minimum 99%, Missing); hippocampal formation: 85.8706% (minimum 99%, Missing); hypothalamus: 79.6206% (minimum 99%, Missing); midbrain: 84.1492% (minimum 99%, Missing); pituitary gland: 96.6274% (minimum 99%, Missing); retina: 78.0035% (minimum 99%, Missing); smooth muscle: 94.1575% (minimum 95%, Enhanced); spinal cord: 90.4762% (minimum 99%, Missing)",0,7,partial,85.4,19.5,5.1,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 12); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 12); smooth muscle: 11.2 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000128596,CCDC136,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0225216,0.00938144,-0.311173
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,13.4,0,0.1,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),56,not_established,not_triggered,,,ENSG00000128610,FEZF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.2740% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.7778% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.6522% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7778% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.7778% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.6522% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 24.7191% (minimum 99%, Baseline (adaptation disabled)); midbrain: 68.7500% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 60.2740% (minimum 99%, Baseline (adaptation disabled)); retina: 64.7059% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.7778% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,13.4,0,0.1,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),56,not_established,not_triggered,,,ENSG00000128610,FEZF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0277778,0.03,-0.742809
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.2740% (minimum 99%, Missing); basal ganglia: 55.0000% (minimum 99%, Missing); cerebellum: 97.7778% (minimum 98%, Approved); cerebral cortex: 95.6522% (minimum 99%, Missing); choroid plexus: 97.7778% (minimum 99%, Missing); heart muscle: 97.7778% (minimum 98%, Approved); hippocampal formation: 95.6522% (minimum 99%, Missing); hypothalamus: 24.7191% (minimum 99%, Missing); midbrain: 68.7500% (minimum 99%, Missing); pituitary gland: 60.2740% (minimum 99%, Missing); retina: 64.7059% (minimum 99%, Missing); spinal cord: 97.7778% (minimum 99%, Missing)",0,2,partial,13.4,0,0.1,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),56,not_established,not_triggered,,,ENSG00000128610,FEZF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.742809
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,6.1,9.9,2.2,"parathyroid gland: 9.9 nTPM (protected, limit 2); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000128655,PDE11A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.6429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.8305% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.3793% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.3636% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.3793% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.9825% (minimum 99%, Baseline (adaptation disabled)); colon: 91.3793% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.8852% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.6429% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.4839% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.3793% (minimum 99%, Baseline (adaptation disabled)); liver: 46.4912% (minimum 99%, Baseline (adaptation disabled)); midbrain: 76.8116% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.8125% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 34.8684% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.8852% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.9825% (minimum 97%, Baseline (adaptation disabled)); retina: 79.1045% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.3030% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.7895% (minimum 99%, Baseline (adaptation disabled)); small intestine: 91.3793% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.1270% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.4321% (minimum 99%, Baseline (adaptation disabled)); stomach: 92.9825% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 76.8116% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.5385% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,6.1,9.9,2.2,"parathyroid gland: 9.9 nTPM (protected, limit 2); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000128655,PDE11A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.243333,-0.621316,-0.525088
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.6667% (minimum 95%, Missing); adrenal gland: 94.6429% (minimum 99%, Missing); amygdala: 89.8305% (minimum 99%, Missing); basal ganglia: 91.3793% (minimum 99%, Missing); bone marrow: 96.3636% (minimum 99%, Missing); cerebral cortex: 91.3793% (minimum 99%, Missing); choroid plexus: 92.9825% (minimum 99%, Missing); colon: 91.3793% (minimum 97%, Missing); duodenum: 86.8852% (minimum 99%, Missing); heart muscle: 94.6429% (minimum 99%, Missing); hippocampal formation: 88.3333% (minimum 99%, Missing); hypothalamus: 85.4839% (minimum 99%, Missing); kidney: 91.3793% (minimum 99%, Missing); liver: 46.4912% (minimum 99%, Missing); midbrain: 76.8116% (minimum 99%, Missing); pancreas: 82.8125% (minimum 99%, Missing); parathyroid gland: 34.8684% (minimum 97%, Missing); pituitary gland: 86.8852% (minimum 99%, Missing); rectum: 92.9825% (minimum 97%, Missing); retina: 79.1045% (minimum 99%, Missing); salivary gland: 80.3030% (minimum 97%, Missing); skeletal muscle: 55.7895% (minimum 99%, Missing); small intestine: 91.3793% (minimum 99%, Missing); smooth muscle: 84.1270% (minimum 99%, Missing); spinal cord: 65.4321% (minimum 99%, Missing); stomach: 92.9825% (minimum 97%, Missing); thyroid gland: 76.8116% (minimum 95%, Missing); tongue: 81.5385% (minimum 97%, Missing)",0,3,partial,6.1,9.9,2.2,"parathyroid gland: 9.9 nTPM (protected, limit 2); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000128655,PDE11A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.243333,-0.621316,-0.525088
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,16.7,50.1,25.8,"lymph node: 50.1 nTPM (protected, limit 2); skin: 25.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 2); rectum: 11.9 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 4); esophagus: 4.8 nTPM (protected, limit 4); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000128886,ELL3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.7500% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.0588% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.2203% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2143% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 51.8868% (minimum 99%, Baseline (adaptation disabled)); colon: 66.5323% (minimum 97%, Baseline (adaptation disabled)); duodenum: 49.6988% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.4648% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.4912% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8024% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 95.9302% (minimum 99%, Baseline (adaptation disabled)); lung: 90.6593% (minimum 99%, Baseline (adaptation disabled)); lymph node: 24.7748% (minimum 97%, Baseline (adaptation disabled)); pancreas: 97.0588% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.1602% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.6331% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.0986% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 85.9375% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.4912% (minimum 99%, Baseline (adaptation disabled)); skin: 39.0071% (minimum 95%, Baseline (adaptation disabled)); small intestine: 52.8846% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.8276% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.1788% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.8421% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.1639% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.8276% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,16.7,50.1,25.8,"lymph node: 50.1 nTPM (protected, limit 2); skin: 25.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000128886,ELL3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.559929,-0.722252,-0.493012
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.7500% (minimum 98%, Approved); bone marrow: 97.0588% (minimum 98%, Approved); cerebellum: 93.2203% (minimum 99%, Missing); cerebral cortex: 98.2143% (minimum 99%, Missing); choroid plexus: 51.8868% (minimum 99%, Missing); colon: 66.5323% (minimum 95%, Approved); duodenum: 49.6988% (minimum 99%, Missing); esophagus: 77.4648% (minimum 95%, Approved); heart muscle: 96.4912% (minimum 98%, Approved); hypothalamus: 98.8024% (minimum 99%, Missing); kidney: 91.6667% (minimum 98%, Approved); liver: 95.9302% (minimum 98%, Approved); lung: 90.6593% (minimum 98%, Approved); lymph node: 24.7748% (minimum 97%, Missing); pancreas: 97.0588% (minimum 98%, Approved); parathyroid gland: 91.1602% (minimum 95%, Approved); pituitary gland: 97.6331% (minimum 99%, Missing); rectum: 58.0986% (minimum 97%, Missing); salivary gland: 85.9375% (minimum 95%, Approved); skeletal muscle: 96.4912% (minimum 98%, Approved); skin: 39.0071% (minimum 95%, Missing); small intestine: 52.8846% (minimum 98%, Approved); smooth muscle: 94.8276% (minimum 98%, Approved); stomach: 86.8421% (minimum 95%, Approved); thymus: 91.6667% (minimum 95%, Missing); tongue: 90.1639% (minimum 97%, Missing); urinary bladder: 94.8276% (minimum 95%, Approved)",0,4,partial,16.7,50.1,25.8,"lymph node: 50.1 nTPM (protected, limit 2); skin: 25.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 2); rectum: 11.9 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 4); esophagus: 4.8 nTPM (protected, limit 4); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000128886,ELL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.559929,-0.722252,-0.493012
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,1,partial,810,0.4,0.5,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000129221,AIPL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 46.1538% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 13.9535% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); retina: 0.0740% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 54.5455% (minimum 95%, Baseline (adaptation disabled)); spleen: 85.7143% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.7143% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,810,0.4,0.5,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000129221,AIPL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.404545,-0.37,-0.98926
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 75.0000% (minimum 99%, Missing); bone marrow: 46.1538% (minimum 95%, Enhanced); cerebral cortex: 75.0000% (minimum 95%, Enhanced); choroid plexus: 13.9535% (minimum 99%, Missing); esophagus: 75.0000% (minimum 80%, Enhanced); pituitary gland: 85.7143% (minimum 99%, Missing); retina: 0.0740% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 80%, Enhanced); skin: 54.5455% (minimum 60%, Enhanced)",0,1,partial,810,0.4,0.5,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000129221,AIPL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.0545455,-0.2,-0.98926
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,307.1,1.9,2.3,"retina: 307.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000129535,NRL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.6735% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.0769% (minimum 99%, Baseline (adaptation disabled)); amygdala: 53.2468% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 52.5641% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.1111% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 69.4915% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 55.4054% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 82.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.3922% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.3922% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.6897% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 56.9444% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.1940% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.7465% (minimum 99%, Baseline (adaptation disabled)); liver: 53.9474% (minimum 99%, Baseline (adaptation disabled)); lung: 80.3922% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.6735% (minimum 97%, Baseline (adaptation disabled)); midbrain: 54.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.9298% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.0625% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.1818% (minimum 97%, Baseline (adaptation disabled)); retina: 1.3175% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 66.1290% (minimum 99%, Baseline (adaptation disabled)); skin: 85.4167% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.9259% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.1818% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 52.5641% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.2131% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.3585% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.3585% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.0625% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.9259% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.8462% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,307.1,1.9,2.3,"retina: 307.1 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000129535,NRL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.309375,-0.286667,-0.976825
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.0769% (minimum 95%, Enhanced); amygdala: 53.2468% (minimum 99%, Missing); basal ganglia: 52.5641% (minimum 99%, Missing); bone marrow: 91.1111% (minimum 95%, Enhanced); cerebellum: 69.4915% (minimum 95%, Enhanced); cerebral cortex: 55.4054% (minimum 95%, Enhanced); choroid plexus: 82.0000% (minimum 99%, Missing); duodenum: 80.3922% (minimum 95%, Enhanced); heart muscle: 70.6897% (minimum 95%, Enhanced); hippocampal formation: 56.9444% (minimum 99%, Missing); hypothalamus: 61.1940% (minimum 99%, Missing); kidney: 57.7465% (minimum 95%, Enhanced); liver: 53.9474% (minimum 95%, Enhanced); lung: 80.3922% (minimum 95%, Enhanced); midbrain: 54.6667% (minimum 99%, Missing); pancreas: 71.9298% (minimum 95%, Enhanced); parathyroid gland: 68.3333% (minimum 80%, Enhanced); pituitary gland: 64.0625% (minimum 99%, Missing); retina: 1.3175% (minimum 99%, Missing); skeletal muscle: 66.1290% (minimum 95%, Enhanced); small intestine: 75.9259% (minimum 95%, Enhanced); smooth muscle: 93.1818% (minimum 95%, Enhanced); spinal cord: 52.5641% (minimum 99%, Missing); stomach: 77.3585% (minimum 80%, Enhanced); thymus: 77.3585% (minimum 95%, Missing); tongue: 75.9259% (minimum 97%, Missing); urinary bladder: 78.8462% (minimum 80%, Enhanced)",0,1,partial,307.1,1.9,2.3,"retina: 307.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000129535,NRL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.176415,-0.210741,-0.976825
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,290.2,278.8,176.3,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 2); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 2); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 2); skin: 176.3 nTPM (manageable, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 2); adipose tissue: 163.6 nTPM (manageable, limit 5); spleen: 160.6 nTPM (manageable, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 2); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 2); pituitary gland: 140.1 nTPM (vital, limit 1); salivary gland: 135.1 nTPM (protected, limit 2); thyroid gland: 128.8 nTPM (manageable, limit 5); small intestine: 125.2 nTPM (vital, limit 1); thymus: 122.3 nTPM (manageable, limit 5); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 2); lymph node: 79.1 nTPM (protected, limit 2); retina: 72.2 nTPM (vital, limit 1); duodenum: 54.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000129559,NEDD8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.2442% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 41.2385% (minimum 99%, Baseline (adaptation disabled)); amygdala: 38.9527% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 37.5154% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 62.9385% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 50.5302% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 34.7301% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 46.4231% (minimum 99%, Baseline (adaptation disabled)); colon: 47.7159% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.7784% (minimum 99%, Baseline (adaptation disabled)); esophagus: 43.7088% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 34.4477% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 42.5502% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 40.9726% (minimum 99%, Baseline (adaptation disabled)); kidney: 44.4736% (minimum 99%, Baseline (adaptation disabled)); liver: 47.0970% (minimum 99%, Baseline (adaptation disabled)); lung: 51.5725% (minimum 99%, Baseline (adaptation disabled)); lymph node: 65.8463% (minimum 97%, Baseline (adaptation disabled)); midbrain: 41.3503% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.6088% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 35.3582% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 52.1189% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.0218% (minimum 97%, Baseline (adaptation disabled)); retina: 67.8683% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.0250% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 34.9450% (minimum 99%, Baseline (adaptation disabled)); skin: 46.3808% (minimum 95%, Baseline (adaptation disabled)); small intestine: 54.9154% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.8661% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 47.5819% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.7065% (minimum 95%, Baseline (adaptation disabled)); stomach: 51.7124% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.4949% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.2126% (minimum 95%, Baseline (adaptation disabled)); tongue: 44.6167% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.9182% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,290.2,278.8,176.3,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 2); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 2); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 2); skin: 176.3 nTPM (manageable, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 2); adipose tissue: 163.6 nTPM (manageable, limit 5); spleen: 160.6 nTPM (manageable, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 2); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 2); pituitary gland: 140.1 nTPM (vital, limit 1); salivary gland: 135.1 nTPM (protected, limit 2); thyroid gland: 128.8 nTPM (manageable, limit 5); small intestine: 125.2 nTPM (vital, limit 1); thymus: 122.3 nTPM (manageable, limit 5); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 2); lymph node: 79.1 nTPM (protected, limit 2); retina: 72.2 nTPM (vital, limit 1); duodenum: 54.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000129559,NEDD8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.486192,-0.616418,-0.645523
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.2442% (minimum 95%, Missing); adrenal gland: 41.2385% (minimum 99%, Missing); amygdala: 38.9527% (minimum 99%, Missing); basal ganglia: 37.5154% (minimum 99%, Missing); bone marrow: 62.9385% (minimum 99%, Missing); cerebellum: 50.5302% (minimum 99%, Missing); cerebral cortex: 34.7301% (minimum 99%, Missing); choroid plexus: 46.4231% (minimum 99%, Missing); colon: 47.7159% (minimum 97%, Missing); duodenum: 73.7784% (minimum 99%, Missing); esophagus: 43.7088% (minimum 97%, Missing); heart muscle: 34.4477% (minimum 99%, Missing); hippocampal formation: 42.5502% (minimum 99%, Missing); hypothalamus: 40.9726% (minimum 99%, Missing); kidney: 44.4736% (minimum 99%, Missing); liver: 47.0970% (minimum 99%, Missing); lung: 51.5725% (minimum 99%, Missing); lymph node: 65.8463% (minimum 97%, Missing); midbrain: 41.3503% (minimum 99%, Missing); pancreas: 58.6088% (minimum 99%, Missing); parathyroid gland: 35.3582% (minimum 97%, Missing); pituitary gland: 52.1189% (minimum 99%, Missing); rectum: 64.0218% (minimum 97%, Missing); retina: 67.8683% (minimum 99%, Missing); salivary gland: 53.0250% (minimum 97%, Missing); skeletal muscle: 34.9450% (minimum 99%, Missing); skin: 46.3808% (minimum 95%, Missing); small intestine: 54.9154% (minimum 99%, Missing); smooth muscle: 61.8661% (minimum 99%, Missing); spinal cord: 47.5819% (minimum 99%, Missing); spleen: 48.7065% (minimum 95%, Missing); stomach: 51.7124% (minimum 97%, Missing); thymus: 55.4949% (minimum 95%, Missing); thyroid gland: 54.2126% (minimum 95%, Missing); tongue: 44.6167% (minimum 97%, Missing); urinary bladder: 50.9182% (minimum 97%, Missing)",0,0,routine_complete,290.2,278.8,176.3,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 2); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 2); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 2); skin: 176.3 nTPM (manageable, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 2); adipose tissue: 163.6 nTPM (manageable, limit 5); spleen: 160.6 nTPM (manageable, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 2); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 2); pituitary gland: 140.1 nTPM (vital, limit 1); salivary gland: 135.1 nTPM (protected, limit 2); thyroid gland: 128.8 nTPM (manageable, limit 5); small intestine: 125.2 nTPM (vital, limit 1); thymus: 122.3 nTPM (manageable, limit 5); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 2); lymph node: 79.1 nTPM (protected, limit 2); retina: 72.2 nTPM (vital, limit 1); duodenum: 54.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000129559,NEDD8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.486192,-0.616418,-0.645523
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,7.3,3.4,4.2,"cerebellum: 7.3 nTPM (vital, limit 6); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000129646,QRICH2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.1957% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.9447% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.6890% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.7692% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.8000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.8863% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.6524% (minimum 99%, Baseline (adaptation disabled)); colon: 92.1875% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.8827% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.8477% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.7098% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.6238% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.0962% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.3061% (minimum 99%, Baseline (adaptation disabled)); liver: 88.9447% (minimum 99%, Baseline (adaptation disabled)); lung: 91.2371% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.1957% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.7692% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.7692% (minimum 99%, Baseline (adaptation disabled)); retina: 87.1921% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.8863% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.6508% (minimum 99%, Baseline (adaptation disabled)); skin: 93.1579% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.1489% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.7901% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.0597% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.1489% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.1489% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 80.8219% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.6524% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,7.3,3.4,4.2,"cerebellum: 7.3 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000129646,QRICH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.141781,-0.131137,-0.282
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 88.9447% (minimum 99%, Missing); basal ganglia: 84.6890% (minimum 99%, Missing); bone marrow: 90.7692% (minimum 95%, Enhanced); cerebellum: 70.8000% (minimum 95%, Enhanced); cerebral cortex: 83.8863% (minimum 95%, Enhanced); choroid plexus: 94.6524% (minimum 99%, Missing); heart muscle: 91.7098% (minimum 95%, Enhanced); hippocampal formation: 87.6238% (minimum 99%, Missing); hypothalamus: 85.0962% (minimum 99%, Missing); kidney: 90.3061% (minimum 95%, Enhanced); liver: 88.9447% (minimum 95%, Enhanced); lung: 91.2371% (minimum 95%, Enhanced); midbrain: 88.5000% (minimum 99%, Missing); pancreas: 90.7692% (minimum 95%, Enhanced); pituitary gland: 90.7692% (minimum 99%, Missing); retina: 87.1921% (minimum 99%, Missing); skeletal muscle: 93.6508% (minimum 95%, Enhanced); small intestine: 94.1489% (minimum 95%, Enhanced); spinal cord: 88.0597% (minimum 99%, Missing)",0,2,partial,7.3,3.4,4.2,"cerebellum: 7.3 nTPM (vital, limit 6); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000129646,QRICH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0225275,0.00252747,-0.242
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.6,1.5,1.3,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000129673,AANAT,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.7447% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.2353% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.8367% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 78.9474% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.2353% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.2353% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.2174% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.8261% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.7500% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.8261% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.2353% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.5385% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 95.7447% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.9057% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.7447% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.7500% (minimum 99%, Baseline (adaptation disabled)); retina: 29.8013% (minimum 99%, Baseline (adaptation disabled)); skin: 77.5862% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.8367% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.2353% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.7447% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 91.8367% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.7447% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.6,1.5,1.3,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000129673,AANAT,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.174138,-0.22,-0.691987
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.7447% (minimum 99%, Missing); amygdala: 88.2353% (minimum 99%, Missing); basal ganglia: 91.8367% (minimum 99%, Missing); bone marrow: 78.9474% (minimum 99%, Missing); cerebellum: 88.2353% (minimum 99%, Missing); cerebral cortex: 88.2353% (minimum 99%, Missing); choroid plexus: 65.2174% (minimum 99%, Missing); duodenum: 97.8261% (minimum 99%, Missing); esophagus: 93.7500% (minimum 97%, Missing); heart muscle: 97.8261% (minimum 99%, Missing); hippocampal formation: 88.2353% (minimum 99%, Missing); hypothalamus: 86.5385% (minimum 99%, Missing); kidney: 93.7500% (minimum 99%, Missing); lung: 95.7447% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 84.9057% (minimum 99%, Missing); pancreas: 95.7447% (minimum 99%, Missing); pituitary gland: 93.7500% (minimum 99%, Missing); retina: 29.8013% (minimum 99%, Missing); skin: 77.5862% (minimum 95%, Missing); small intestine: 91.8367% (minimum 99%, Missing); spinal cord: 88.2353% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 95.7447% (minimum 97%, Missing); thyroid gland: 91.8367% (minimum 95%, Missing); urinary bladder: 95.7447% (minimum 97%, Missing)",0,80,unavailable,10.6,1.5,1.3,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000129673,AANAT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.174138,-0.22,-0.691987
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,9,partial,8.6,6.1,12.6,"thymus: 12.6 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 6); lymph node: 6.1 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; appendix / germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000129810,SGO1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.4848% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 43.0464% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.0149% (minimum 99%, Baseline (adaptation disabled)); colon: 76.4706% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.7126% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.3810% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.4848% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.5882% (minimum 99%, Baseline (adaptation disabled)); liver: 91.5493% (minimum 99%, Baseline (adaptation disabled)); lung: 95.5882% (minimum 99%, Baseline (adaptation disabled)); lymph node: 51.5873% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.4848% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.6522% (minimum 97%, Baseline (adaptation disabled)); retina: 98.4848% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.2029% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.4848% (minimum 99%, Baseline (adaptation disabled)); skin: 85.5263% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.0337% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.8378% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.4848% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.2785% (minimum 97%, Baseline (adaptation disabled)); thymus: 34.0314% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 87.8378% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,8.6,6.1,12.6,"thymus: 12.6 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; appendix / germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000129810,SGO1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.609686,-0.454127,-0.559536
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 43.0464% (minimum 95%, Enhanced); colon: 76.4706% (minimum 97%, Missing); duodenum: 74.7126% (minimum 99%, Missing); esophagus: 77.3810% (minimum 97%, Missing); liver: 91.5493% (minimum 95%, Enhanced); lymph node: 51.5873% (minimum 97%, Missing); rectum: 70.6522% (minimum 97%, Missing); retina: 98.4848% (minimum 99%, Missing); skin: 85.5263% (minimum 95%, Missing); small intestine: 73.0337% (minimum 99%, Missing); smooth muscle: 87.8378% (minimum 95%, Enhanced); spinal cord: 98.4848% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 82.2785% (minimum 97%, Missing); thymus: 34.0314% (minimum 95%, Missing); urinary bladder: 87.8378% (minimum 97%, Missing)",0,9,partial,8.6,6.1,12.6,"thymus: 12.6 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 6); lymph node: 6.1 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; appendix / germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000129810,SGO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.609686,-0.454127,-0.519536
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000129862,VCY1B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000129862,VCY1B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000129862,VCY1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,7,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000129864,VCY,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,7,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000129864,VCY,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,7,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000129864,VCY,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000129873,CDY2B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000129873,CDY2B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000129873,CDY2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,3,partial,5.1,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,ENSG00000130167,TSPAN16,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 96.2500% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,5.1,0.1,0.2,"bone marrow: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,ENSG00000130167,TSPAN16,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0484744,0.0292366,-0.0275
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,3,partial,5.1,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,ENSG00000130167,TSPAN16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00543726
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,12,partial,237.9,9.6,8.6,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); heart muscle: 41.3 nTPM (vital, limit 6); colon: 9.6 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); choroid plexus: 5.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130234,ACE2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 84.9387% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.9796% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.7780% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.9814% (minimum 99%, Baseline (adaptation disabled)); colon: 83.4768% (minimum 97%, Baseline (adaptation disabled)); duodenum: 21.3000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.6135% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.0089% (minimum 99%, Baseline (adaptation disabled)); kidney: 36.2752% (minimum 99%, Baseline (adaptation disabled)); liver: 89.6488% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5772% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.2849% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.3186% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.7780% (minimum 99%, Baseline (adaptation disabled)); small intestine: 16.9344% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.9796% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.9119% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 91.8561% (minimum 95%, Baseline (adaptation disabled))",0,12,partial,237.9,9.6,8.6,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); heart muscle: 41.3 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 2); adipose tissue: 8.6 nTPM (manageable, limit 5); rectum: 5.8 nTPM (protected, limit 2); liver: 5.6 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130234,ACE2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.100613,-0.135232,-0.820656
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 89.9814% (minimum 99%, Missing); colon: 83.4768% (minimum 97%, Missing); duodenum: 21.3000% (minimum 99%, Missing); heart muscle: 54.0089% (minimum 95%, Enhanced); kidney: 36.2752% (minimum 99%, Missing); liver: 89.6488% (minimum 95%, Enhanced); pancreas: 95.2849% (minimum 99%, Missing); rectum: 89.3186% (minimum 97%, Missing); small intestine: 16.9344% (minimum 99%, Missing)",0,12,partial,237.9,9.6,8.6,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); heart muscle: 41.3 nTPM (vital, limit 6); colon: 9.6 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); choroid plexus: 5.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130234,ACE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0397959,-0.135232,-0.820656
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.8,0.7,3.2,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130270,ATP8B3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.8103% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 78.5978% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.1567% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.6111% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2603% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7064% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.8182% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.6111% (minimum 99%, Baseline (adaptation disabled)); retina: 98.1567% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.1567% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.8182% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.9388% (minimum 95%, Baseline (adaptation disabled)); thymus: 90.6383% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,5.8,0.7,3.2,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130270,ATP8B3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0806122,-0.00181818,-0.204022
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.8103% (minimum 99%, Missing); bone marrow: 78.5978% (minimum 99%, Missing); choroid plexus: 98.1567% (minimum 99%, Missing); duodenum: 98.6111% (minimum 99%, Missing); liver: 97.2603% (minimum 99%, Missing); lung: 97.7064% (minimum 99%, Missing); lymph node: 96.8182% (minimum 97%, Missing); pituitary gland: 98.6111% (minimum 99%, Missing); retina: 98.1567% (minimum 99%, Missing); small intestine: 98.1567% (minimum 99%, Missing); smooth muscle: 96.8182% (minimum 99%, Missing); spleen: 86.9388% (minimum 95%, Missing); thymus: 90.6383% (minimum 95%, Missing)",0,80,unavailable,5.8,0.7,3.2,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130270,ATP8B3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0806122,-0.00181818,-0.204022
True,compatible,,True,True,False,,0,1,partial,0.5,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000130377,ACSBG2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.5,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000130377,ACSBG2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0484089,0.0292038,0.00603175
True,compatible,,True,True,True,,0,1,partial,0.5,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000130377,ACSBG2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00682288
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.5,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000130383,FUT5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 28.5714% (minimum 99%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000130383,FUT5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.303333,-0.704286
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 28.5714% (minimum 99%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing)",0,80,unavailable,0.5,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000130383,FUT5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.303333,-0.704286
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000130385,BMP15,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000130385,BMP15,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000130385,BMP15,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,9,partial,3.4,1.1,2.4,"choroid plexus: 3.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130518,IQCN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.2079% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.9170% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2079% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.6388% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.8356% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2079% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.9610% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.5612% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.8198% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.9170% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9170% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.8571% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.8571% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2079% (minimum 99%, Baseline (adaptation disabled)); lung: 93.8356% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.4789% (minimum 97%, Baseline (adaptation disabled)); pancreas: 96.4789% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.5154% (minimum 99%, Baseline (adaptation disabled)); retina: 93.1973% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.4789% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.1389% (minimum 99%, Baseline (adaptation disabled)); skin: 92.5676% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.4704% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.1389% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9170% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.5154% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.1404% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 91.9463% (minimum 95%, Baseline (adaptation disabled))",0,9,partial,3.4,1.1,2.4,"choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130518,IQCN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0305369,-0.00859649,-0.10039
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.9170% (minimum 99%, Missing); basal ganglia: 98.2079% (minimum 99%, Missing); bone marrow: 91.6388% (minimum 95%, Enhanced); cerebellum: 93.8356% (minimum 99%, Missing); choroid plexus: 88.9610% (minimum 99%, Missing); hippocampal formation: 98.9170% (minimum 99%, Missing); hypothalamus: 97.8571% (minimum 99%, Missing); lung: 93.8356% (minimum 95%, Enhanced); pituitary gland: 93.5154% (minimum 99%, Missing); retina: 93.1973% (minimum 99%, Missing); spinal cord: 98.9170% (minimum 99%, Missing)",0,9,partial,3.4,1.1,2.4,"choroid plexus: 3.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130518,IQCN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0181979,0.03,-0.10039
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.7,2.5,2.3,"bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130544,ZNF557,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 52.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.7419% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.6250% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 36.2069% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 51.2195% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.8462% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.4138% (minimum 99%, Baseline (adaptation disabled)); colon: 58.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.6250% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.2632% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.6364% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.6364% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.6250% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.2632% (minimum 99%, Baseline (adaptation disabled)); liver: 50.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 61.7647% (minimum 99%, Baseline (adaptation disabled)); lymph node: 45.6522% (minimum 97%, Baseline (adaptation disabled)); midbrain: 67.7419% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.2632% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.2632% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.7647% (minimum 97%, Baseline (adaptation disabled)); retina: 55.2632% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.7647% (minimum 99%, Baseline (adaptation disabled)); skin: 52.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.7568% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.6364% (minimum 99%, Baseline (adaptation disabled)); spleen: 47.7273% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.2632% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.7273% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.7419% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.7,2.5,2.3,"bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130544,ZNF557,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.472727,-0.513478,-0.627931
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.3333% (minimum 95%, Missing); adrenal gland: 52.5000% (minimum 99%, Missing); amygdala: 67.7419% (minimum 99%, Missing); basal ganglia: 65.6250% (minimum 99%, Missing); bone marrow: 36.2069% (minimum 99%, Missing); cerebellum: 51.2195% (minimum 99%, Missing); cerebral cortex: 53.8462% (minimum 99%, Missing); choroid plexus: 72.4138% (minimum 99%, Missing); colon: 58.3333% (minimum 97%, Missing); duodenum: 65.6250% (minimum 99%, Missing); esophagus: 55.2632% (minimum 97%, Missing); heart muscle: 63.6364% (minimum 99%, Missing); hippocampal formation: 63.6364% (minimum 99%, Missing); hypothalamus: 65.6250% (minimum 99%, Missing); kidney: 55.2632% (minimum 99%, Missing); liver: 50.0000% (minimum 99%, Missing); lung: 61.7647% (minimum 99%, Missing); lymph node: 45.6522% (minimum 97%, Missing); midbrain: 67.7419% (minimum 99%, Missing); pancreas: 55.2632% (minimum 99%, Missing); parathyroid gland: 55.2632% (minimum 97%, Missing); pituitary gland: 58.3333% (minimum 99%, Missing); rectum: 61.7647% (minimum 97%, Missing); retina: 55.2632% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 97%, Missing); skeletal muscle: 61.7647% (minimum 99%, Missing); skin: 52.5000% (minimum 95%, Missing); small intestine: 56.7568% (minimum 99%, Missing); smooth muscle: 58.3333% (minimum 99%, Missing); spinal cord: 63.6364% (minimum 99%, Missing); spleen: 47.7273% (minimum 95%, Missing); stomach: 55.2632% (minimum 97%, Missing); thymus: 47.7273% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 67.7419% (minimum 97%, Missing); urinary bladder: 58.3333% (minimum 97%, Missing)",0,80,unavailable,3.7,2.5,2.3,"bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130544,ZNF557,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.472727,-0.513478,-0.627931
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,1421.5,0,0.1,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),57,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000130561,SAG,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.7742% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 44.7761% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.7742% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.7742% (minimum 99%, Baseline (adaptation disabled)); retina: 0.2106% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,1421.5,0,0.1,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),57,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000130561,SAG,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0177419,0.03,-0.987894
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.7742% (minimum 99%, Missing); basal ganglia: 44.7761% (minimum 99%, Missing); hypothalamus: 96.7742% (minimum 99%, Missing); midbrain: 96.7742% (minimum 99%, Missing); retina: 0.2106% (minimum 99%, Missing)",0,5,partial,1421.5,0,0.1,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),57,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000130561,SAG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.987894
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,3.9,0.2,0.6,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; spleen / cells in red pulp,ENSG00000130656,HBZ,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.2078% (minimum 95%, Baseline (adaptation disabled)); amygdala: 91.0256% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.5455% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.4211% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.5238% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.2603% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.4211% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.9459% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6111% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2603% (minimum 99%, Baseline (adaptation disabled)); lung: 93.4211% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.2603% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.6111% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.6111% (minimum 99%, Baseline (adaptation disabled)); skin: 94.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.6111% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.2603% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,3.9,0.2,0.6,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; spleen / cells in red pulp,ENSG00000130656,HBZ,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0279221,0.00260274,-0.344545
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.0256% (minimum 99%, Missing); basal ganglia: 94.6667% (minimum 99%, Missing); bone marrow: 64.5455% (minimum 99%, Missing); cerebellum: 94.6667% (minimum 98%, Approved); cerebral cortex: 93.4211% (minimum 98%, Approved); choroid plexus: 84.5238% (minimum 99%, Missing); heart muscle: 97.2603% (minimum 98%, Approved); hippocampal formation: 93.4211% (minimum 99%, Missing); hypothalamus: 95.9459% (minimum 99%, Missing); liver: 97.2603% (minimum 98%, Approved); lung: 93.4211% (minimum 98%, Approved); midbrain: 97.2603% (minimum 99%, Missing); pituitary gland: 98.6111% (minimum 99%, Missing); spinal cord: 97.2603% (minimum 99%, Missing)",0,2,partial,3.9,0.2,0.6,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; spleen / cells in red pulp,ENSG00000130656,HBZ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00945946,0.0226027,-0.344545
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,1.4,0.3,0.5,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130783,CCDC62,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 98.9811% (minimum 99%, Baseline (adaptation disabled)); retina: 97.9827% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,1.4,0.3,0.5,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130783,CCDC62,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0427007,0.0256076,-0.0101729
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.9827% (minimum 99%, Missing)",0,2,partial,1.4,0.3,0.5,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000130783,CCDC62,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0470674,0.0256076,-0.0101729
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,31.6,27,27.3,"skeletal muscle: 31.6 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 27 nTPM (protected, limit 2); spleen: 25.9 nTPM (manageable, limit 5); liver: 23.9 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); pancreas: 22.5 nTPM (vital, limit 1); adrenal gland: 19.8 nTPM (vital, limit 1); urinary bladder: 19.8 nTPM (protected, limit 2); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 2); stomach: 17.8 nTPM (protected, limit 2); lymph node: 17.2 nTPM (protected, limit 2); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); salivary gland: 16.2 nTPM (protected, limit 2); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 2); thymus: 9.6 nTPM (manageable, limit 5); parathyroid gland: 8 nTPM (protected, limit 2); smooth muscle: 6.4 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000130810,PPAN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.9340% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 50.1259% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.3824% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.6707% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.3758% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.0761% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.0201% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 59.2262% (minimum 99%, Baseline (adaptation disabled)); colon: 52.3684% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.7760% (minimum 99%, Baseline (adaptation disabled)); esophagus: 42.4307% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 53.7838% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 60.4863% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.7760% (minimum 99%, Baseline (adaptation disabled)); kidney: 52.0942% (minimum 99%, Baseline (adaptation disabled)); liver: 45.4338% (minimum 99%, Baseline (adaptation disabled)); lung: 58.0175% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.6388% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.6104% (minimum 99%, Baseline (adaptation disabled)); pancreas: 46.9340% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.3262% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.7598% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.9197% (minimum 97%, Baseline (adaptation disabled)); retina: 82.2314% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.1247% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 38.6408% (minimum 99%, Baseline (adaptation disabled)); skin: 42.1610% (minimum 95%, Baseline (adaptation disabled)); small intestine: 50.6361% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.6654% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.2459% (minimum 99%, Baseline (adaptation disabled)); spleen: 43.4498% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.7851% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.4576% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.2147% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.6766% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.1259% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,31.6,27,27.3,"skeletal muscle: 31.6 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 27 nTPM (protected, limit 2); spleen: 25.9 nTPM (manageable, limit 5); liver: 23.9 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); pancreas: 22.5 nTPM (vital, limit 1); adrenal gland: 19.8 nTPM (vital, limit 1); urinary bladder: 19.8 nTPM (protected, limit 2); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 2); stomach: 17.8 nTPM (protected, limit 2); lymph node: 17.2 nTPM (protected, limit 2); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); salivary gland: 16.2 nTPM (protected, limit 2); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 2); thymus: 9.6 nTPM (manageable, limit 5); parathyroid gland: 8 nTPM (protected, limit 2); smooth muscle: 6.4 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000130810,PPAN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.52839,-0.545693,-0.603592
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.9340% (minimum 95%, Missing); adrenal gland: 50.1259% (minimum 99%, Missing); amygdala: 62.3824% (minimum 99%, Missing); basal ganglia: 60.6707% (minimum 99%, Missing); bone marrow: 63.3758% (minimum 99%, Missing); cerebellum: 54.0761% (minimum 99%, Missing); cerebral cortex: 57.0201% (minimum 99%, Missing); choroid plexus: 59.2262% (minimum 99%, Missing); colon: 52.3684% (minimum 97%, Missing); duodenum: 62.7760% (minimum 99%, Missing); esophagus: 42.4307% (minimum 97%, Missing); heart muscle: 53.7838% (minimum 99%, Missing); hippocampal formation: 60.4863% (minimum 99%, Missing); hypothalamus: 62.7760% (minimum 99%, Missing); kidney: 52.0942% (minimum 99%, Missing); liver: 45.4338% (minimum 99%, Missing); lung: 58.0175% (minimum 99%, Missing); lymph node: 53.6388% (minimum 97%, Missing); midbrain: 64.6104% (minimum 99%, Missing); pancreas: 46.9340% (minimum 99%, Missing); parathyroid gland: 71.3262% (minimum 97%, Missing); pituitary gland: 59.7598% (minimum 99%, Missing); rectum: 79.9197% (minimum 97%, Missing); retina: 82.2314% (minimum 99%, Missing); salivary gland: 55.1247% (minimum 97%, Missing); skeletal muscle: 38.6408% (minimum 99%, Missing); skin: 42.1610% (minimum 95%, Missing); small intestine: 50.6361% (minimum 99%, Missing); smooth muscle: 75.6654% (minimum 99%, Missing); spinal cord: 65.2459% (minimum 99%, Missing); spleen: 43.4498% (minimum 95%, Missing); stomach: 52.7851% (minimum 97%, Missing); thymus: 67.4576% (minimum 95%, Missing); thyroid gland: 56.2147% (minimum 95%, Missing); tongue: 65.6766% (minimum 97%, Missing); urinary bladder: 50.1259% (minimum 97%, Missing)",0,3,partial,31.6,27,27.3,"skeletal muscle: 31.6 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 27 nTPM (protected, limit 2); spleen: 25.9 nTPM (manageable, limit 5); liver: 23.9 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); pancreas: 22.5 nTPM (vital, limit 1); adrenal gland: 19.8 nTPM (vital, limit 1); urinary bladder: 19.8 nTPM (protected, limit 2); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 2); stomach: 17.8 nTPM (protected, limit 2); lymph node: 17.2 nTPM (protected, limit 2); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); salivary gland: 16.2 nTPM (protected, limit 2); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 2); thymus: 9.6 nTPM (manageable, limit 5); parathyroid gland: 8 nTPM (protected, limit 2); smooth muscle: 6.4 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000130810,PPAN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.52839,-0.545693,-0.603592
True,compatible,,True,True,False,,0,5,partial,0.3,0.1,0.5,,,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000130943,PKDREJ,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.0588% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.0588% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.0588% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.0588% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.0588% (minimum 99%, Baseline (adaptation disabled)); duodenum: 94.2857% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.0588% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.2857% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.0588% (minimum 99%, Baseline (adaptation disabled)); retina: 94.2857% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.0588% (minimum 99%, Baseline (adaptation disabled)); skin: 86.8421% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.2857% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.0588% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,0.3,0.1,0.5,,,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000130943,PKDREJ,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,-0.0815789,0.000588235,-0.0733333
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 97.0588% (minimum 99%, Missing); duodenum: 94.2857% (minimum 95%, Enhanced); heart muscle: 91.6667% (minimum 95%, Enhanced); pancreas: 94.2857% (minimum 95%, Enhanced); pituitary gland: 97.0588% (minimum 99%, Missing); retina: 94.2857% (minimum 99%, Missing); small intestine: 94.2857% (minimum 95%, Enhanced); spinal cord: 97.0588% (minimum 99%, Missing)",0,5,partial,0.3,0.1,0.5,,,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000130943,PKDREJ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,0.05,0.000588235,-0.0471429
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,14.8,2.6,9.7,"liver: 14.8 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000130948,HSD17B3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8082% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.7273% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.7738% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0769% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.7008% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8920% (minimum 99%, Baseline (adaptation disabled)); colon: 93.2115% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.6188% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.4444% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.6985% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.1953% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.5856% (minimum 99%, Baseline (adaptation disabled)); liver: 70.6931% (minimum 99%, Baseline (adaptation disabled)); lung: 95.2000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 89.4737% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.9244% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.4545% (minimum 99%, Baseline (adaptation disabled)); retina: 98.0769% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.6188% (minimum 99%, Baseline (adaptation disabled)); small intestine: 90.8397% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.7150% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.2264% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 78.6344% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.7105% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,14.8,2.6,9.7,"liver: 14.8 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); spinal cord: 5 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000130948,HSD17B3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.163656,-0.0378851,-0.283069
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 92.7273% (minimum 99%, Missing); basal ganglia: 91.7738% (minimum 99%, Missing); cerebral cortex: 93.7008% (minimum 95%, Enhanced); choroid plexus: 98.8920% (minimum 99%, Missing); heart muscle: 94.4444% (minimum 95%, Enhanced); hippocampal formation: 89.6985% (minimum 99%, Missing); hypothalamus: 94.1953% (minimum 99%, Missing); kidney: 88.5856% (minimum 95%, Enhanced); liver: 70.6931% (minimum 95%, Enhanced); midbrain: 89.4737% (minimum 99%, Missing); pancreas: 89.9244% (minimum 95%, Enhanced); pituitary gland: 95.4545% (minimum 99%, Missing); retina: 98.0769% (minimum 99%, Missing); small intestine: 90.8397% (minimum 95%, Enhanced); spinal cord: 87.7150% (minimum 99%, Missing)",0,1,partial,14.8,2.6,9.7,"liver: 14.8 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000130948,HSD17B3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0272067,-0.243069
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000130950,NUTM2F,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 94.7368% (minimum 99%, Baseline (adaptation disabled)); liver: 94.7368% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000130950,NUTM2F,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.0426316
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 94.7368% (minimum 99%, Missing); liver: 94.7368% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000130950,NUTM2F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.0426316
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,6.3,1.8,4.8,"skeletal muscle: 6.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000131019,ULBP3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.5616% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.5616% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.3125% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.3125% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.7059% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.4058% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.1429% (minimum 99%, Baseline (adaptation disabled)); colon: 88.4058% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.9155% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.2632% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.7059% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.3125% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.0448% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.2208% (minimum 99%, Baseline (adaptation disabled)); liver: 87.1429% (minimum 99%, Baseline (adaptation disabled)); lung: 81.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.4242% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.3871% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.0448% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.1429% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.3871% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.7059% (minimum 97%, Baseline (adaptation disabled)); retina: 89.7059% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.8462% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 49.1935% (minimum 99%, Baseline (adaptation disabled)); skin: 85.9155% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.4242% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.4242% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.3871% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.0448% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.2152% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.4242% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.9633% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.8462% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.9155% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,6.3,1.8,4.8,"skeletal muscle: 6.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000131019,ULBP3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.390367,-0.197848,-0.498065
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.5616% (minimum 90%, Approved); adrenal gland: 83.5616% (minimum 98%, Approved); amygdala: 95.3125% (minimum 99%, Missing); basal ganglia: 95.3125% (minimum 99%, Missing); bone marrow: 89.7059% (minimum 99%, Missing); cerebral cortex: 88.4058% (minimum 98%, Approved); choroid plexus: 87.1429% (minimum 99%, Missing); colon: 88.4058% (minimum 95%, Approved); duodenum: 85.9155% (minimum 98%, Approved); esophagus: 80.2632% (minimum 97%, Missing); heart muscle: 89.7059% (minimum 98%, Approved); hippocampal formation: 95.3125% (minimum 99%, Missing); hypothalamus: 91.0448% (minimum 99%, Missing); kidney: 79.2208% (minimum 98%, Approved); liver: 87.1429% (minimum 98%, Approved); lung: 81.3333% (minimum 98%, Approved); lymph node: 92.4242% (minimum 97%, Missing); midbrain: 98.3871% (minimum 99%, Missing); pancreas: 91.0448% (minimum 98%, Approved); parathyroid gland: 87.1429% (minimum 95%, Approved); pituitary gland: 98.3871% (minimum 99%, Missing); rectum: 89.7059% (minimum 97%, Missing); retina: 89.7059% (minimum 99%, Missing); salivary gland: 93.8462% (minimum 95%, Approved); skeletal muscle: 49.1935% (minimum 98%, Approved); skin: 85.9155% (minimum 95%, Missing); small intestine: 92.4242% (minimum 98%, Approved); smooth muscle: 92.4242% (minimum 98%, Approved); spinal cord: 98.3871% (minimum 99%, Missing); spleen: 91.0448% (minimum 95%, Missing); stomach: 77.2152% (minimum 97%, Missing); thymus: 92.4242% (minimum 95%, Missing); thyroid gland: 55.9633% (minimum 90%, Approved); tongue: 93.8462% (minimum 97%, Missing); urinary bladder: 85.9155% (minimum 95%, Approved)",0,2,partial,6.3,1.8,4.8,"skeletal muscle: 6.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000131019,ULBP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.340367,-0.197848,-0.488065
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,15,0.6,0.6,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,ENSG00000131044,TTLL9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.3607% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.9231% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.9655% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.2353% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.5070% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 28.5714% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.5882% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.7674% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.5522% (minimum 99%, Baseline (adaptation disabled)); lung: 84.5070% (minimum 99%, Baseline (adaptation disabled)); midbrain: 75.9494% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7742% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.9565% (minimum 99%, Baseline (adaptation disabled)); retina: 93.7500% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.3607% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.2892% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 90.9091% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,15,0.6,0.6,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,ENSG00000131044,TTLL9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0409091,-0.0609091,-0.704286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.3607% (minimum 99%, Missing); amygdala: 76.9231% (minimum 99%, Missing); basal ganglia: 68.9655% (minimum 99%, Missing); cerebellum: 88.2353% (minimum 99%, Missing); cerebral cortex: 84.5070% (minimum 99%, Missing); choroid plexus: 28.5714% (minimum 99%, Missing); hippocampal formation: 70.5882% (minimum 99%, Missing); hypothalamus: 69.7674% (minimum 99%, Missing); kidney: 89.5522% (minimum 99%, Missing); lung: 84.5070% (minimum 99%, Missing); midbrain: 75.9494% (minimum 99%, Missing); pancreas: 96.7742% (minimum 99%, Missing); parathyroid gland: 90.9091% (minimum 97%, Missing); pituitary gland: 86.9565% (minimum 99%, Missing); retina: 93.7500% (minimum 99%, Missing); small intestine: 98.3607% (minimum 99%, Missing); spinal cord: 72.2892% (minimum 99%, Missing); thyroid gland: 90.9091% (minimum 95%, Missing)",0,80,unavailable,15,0.6,0.6,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,ENSG00000131044,TTLL9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0409091,-0.0609091,-0.704286
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,3.8,6665.1,0.3,"salivary gland: 6665.1 nTPM (protected, limit 2)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; salivary gland / glandular cells; skin,ENSG00000131050,BPIFA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 91.1111% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 82.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6190% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.1818% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6190% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.8987% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 0.0615% (minimum 97%, Baseline (adaptation disabled)); skin: 93.1818% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.1818% (minimum 95%, Baseline (adaptation disabled))",0,5,partial,3.8,6665.1,0.3,"salivary gland: 6665.1 nTPM (protected, limit 2); pancreas: 3.8 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; salivary gland / glandular cells; skin,ENSG00000131050,BPIFA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.0181818,-0.969385,-0.471013
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 91.1111% (minimum 95%, Enhanced); heart muscle: 82.0000% (minimum 95%, Enhanced); hippocampal formation: 97.6190% (minimum 99%, Missing); kidney: 93.1818% (minimum 95%, Enhanced); pancreas: 51.8987% (minimum 95%, Enhanced); salivary gland: 0.0615% (minimum 97%, Missing)",0,5,partial,3.8,6665.1,0.3,"salivary gland: 6665.1 nTPM (protected, limit 2)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; salivary gland / glandular cells; skin,ENSG00000131050,BPIFA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,-0.969385,-0.431013
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000131059,BPIFA3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000131059,BPIFA3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000131059,BPIFA3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000131068,DEFB118,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000131068,DEFB118,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000131068,DEFB118,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,9.8,10.1,16.7,"thymus: 16.7 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 2); parathyroid gland: 10 nTPM (protected, limit 2); cerebellum: 9.8 nTPM (vital, limit 1); spleen: 9.2 nTPM (manageable, limit 5); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 2); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); kidney: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); pancreas: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 2); skeletal muscle: 6.2 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); lung: 5.9 nTPM (vital, limit 1); small intestine: 5.6 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 2); heart muscle: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); choroid plexus: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000131115,ZNF227,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.2530% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.0465% (minimum 99%, Baseline (adaptation disabled)); amygdala: 60.3448% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.7647% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.1818% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 51.7241% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.4035% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.4557% (minimum 99%, Baseline (adaptation disabled)); colon: 61.0465% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.4557% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.1302% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.6250% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 60.6936% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.0465% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.0465% (minimum 99%, Baseline (adaptation disabled)); liver: 59.3220% (minimum 99%, Baseline (adaptation disabled)); lung: 64.0244% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.9709% (minimum 97%, Baseline (adaptation disabled)); midbrain: 57.6923% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.1302% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.2195% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.3770% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.2174% (minimum 97%, Baseline (adaptation disabled)); retina: 55.2632% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.0377% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.8743% (minimum 99%, Baseline (adaptation disabled)); skin: 62.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.2174% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.7647% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.1497% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.2995% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.5556% (minimum 97%, Baseline (adaptation disabled)); thymus: 38.6029% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.7568% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.8743% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.3448% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,9.8,10.1,16.7,"thymus: 16.7 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 2); parathyroid gland: 10 nTPM (protected, limit 2); cerebellum: 9.8 nTPM (vital, limit 1); spleen: 9.2 nTPM (manageable, limit 5); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 2); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); kidney: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); pancreas: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 2); skeletal muscle: 6.2 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); lung: 5.9 nTPM (vital, limit 1); small intestine: 5.6 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 2); heart muscle: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); choroid plexus: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000131115,ZNF227,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.563971,-0.460291,-0.472759
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.2530% (minimum 95%, Uncertain); adrenal gland: 61.0465% (minimum 99%, Uncertain); amygdala: 60.3448% (minimum 99%, Missing); basal ganglia: 61.7647% (minimum 99%, Missing); bone marrow: 68.1818% (minimum 99%, Missing); cerebellum: 51.7241% (minimum 99%, Missing); cerebral cortex: 61.4035% (minimum 99%, Missing); choroid plexus: 66.4557% (minimum 99%, Missing); colon: 61.0465% (minimum 97%, Missing); duodenum: 66.4557% (minimum 99%, Missing); esophagus: 62.1302% (minimum 97%, Missing); heart muscle: 65.6250% (minimum 99%, Missing); hippocampal formation: 60.6936% (minimum 99%, Missing); hypothalamus: 61.0465% (minimum 99%, Missing); kidney: 61.0465% (minimum 99%, Missing); liver: 59.3220% (minimum 99%, Missing); lung: 64.0244% (minimum 99%, Missing); lymph node: 50.9709% (minimum 97%, Uncertain); midbrain: 57.6923% (minimum 99%, Missing); pancreas: 62.1302% (minimum 99%, Missing); parathyroid gland: 51.2195% (minimum 97%, Missing); pituitary gland: 57.3770% (minimum 99%, Missing); rectum: 65.2174% (minimum 97%, Missing); retina: 55.2632% (minimum 99%, Missing); salivary gland: 66.0377% (minimum 97%, Missing); skeletal muscle: 62.8743% (minimum 99%, Uncertain); skin: 62.5000% (minimum 95%, Missing); small intestine: 65.2174% (minimum 99%, Missing); smooth muscle: 61.7647% (minimum 99%, Uncertain); spinal cord: 56.1497% (minimum 99%, Missing); spleen: 53.2995% (minimum 95%, Missing); stomach: 55.5556% (minimum 97%, Missing); thymus: 38.6029% (minimum 95%, Missing); thyroid gland: 56.7568% (minimum 95%, Missing); tongue: 62.8743% (minimum 97%, Missing); urinary bladder: 60.3448% (minimum 97%, Missing)",0,1,partial,9.8,10.1,16.7,"thymus: 16.7 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 2); parathyroid gland: 10 nTPM (protected, limit 2); cerebellum: 9.8 nTPM (vital, limit 1); spleen: 9.2 nTPM (manageable, limit 5); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 2); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); kidney: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); pancreas: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 2); skeletal muscle: 6.2 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); lung: 5.9 nTPM (vital, limit 1); small intestine: 5.6 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 2); heart muscle: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); choroid plexus: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000131115,ZNF227,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.563971,-0.460291,-0.472759
True,compatible,,True,True,False,,0,6,partial,1.5,1.2,1.5,,,49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000131126,TEX101,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 98.7058% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,1.5,1.2,1.5,"pancreas: 1.5 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000131126,TEX101,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0370578,0.0196194,-0.00294219
True,compatible,,True,True,True,,0,6,partial,1.5,1.2,1.5,,,49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000131126,TEX101,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0413345,0.0282548,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus; tonsil,ENSG00000131379,C3orf20,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 95.5224% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.4615% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.4615% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.4615% (minimum 99%, Baseline (adaptation disabled)); liver: 98.4615% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.9697% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.4615% (minimum 99%, Baseline (adaptation disabled)); retina: 94.1176% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus; tonsil,ENSG00000131379,C3orf20,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0346154,-0.00030303,-0.0488235
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 95.5224% (minimum 99%, Missing); cerebral cortex: 98.4615% (minimum 99%, Missing); duodenum: 98.4615% (minimum 99%, Missing); kidney: 98.4615% (minimum 99%, Missing); liver: 98.4615% (minimum 99%, Missing); lymph node: 96.9697% (minimum 97%, Missing); pancreas: 98.4615% (minimum 99%, Missing); retina: 94.1176% (minimum 99%, Missing)",0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus; tonsil,ENSG00000131379,C3orf20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0346154,-0.00030303,-0.0488235
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,274,223.4,76,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 2); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); salivary gland: 99 nTPM (protected, limit 2); parathyroid gland: 96.2 nTPM (protected, limit 2); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 2); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 2); pituitary gland: 77 nTPM (vital, limit 1); thymus: 76 nTPM (manageable, limit 5); adipose tissue: 73.4 nTPM (manageable, limit 5); esophagus: 71.4 nTPM (protected, limit 2); spleen: 70.9 nTPM (manageable, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 2); thyroid gland: 62.2 nTPM (manageable, limit 5); rectum: 59 nTPM (protected, limit 2); urinary bladder: 53.4 nTPM (protected, limit 2); lung: 51.7 nTPM (vital, limit 1); skin: 50.7 nTPM (manageable, limit 5); retina: 50.2 nTPM (vital, limit 1); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000131495,NDUFA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.3585% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 38.4615% (minimum 99%, Baseline (adaptation disabled)); amygdala: 38.3474% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 39.3002% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 45.0320% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.0459% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 40.1139% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 24.3099% (minimum 99%, Baseline (adaptation disabled)); colon: 49.7752% (minimum 97%, Baseline (adaptation disabled)); duodenum: 46.9697% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.0484% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 28.8533% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 42.8177% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 41.7790% (minimum 99%, Baseline (adaptation disabled)); kidney: 35.4691% (minimum 99%, Baseline (adaptation disabled)); liver: 35.3881% (minimum 99%, Baseline (adaptation disabled)); lung: 59.9845% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.6159% (minimum 97%, Baseline (adaptation disabled)); midbrain: 38.4234% (minimum 99%, Baseline (adaptation disabled)); pancreas: 49.5524% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 44.6172% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 50.1618% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.7766% (minimum 97%, Baseline (adaptation disabled)); retina: 60.6891% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 43.9093% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 22.0484% (minimum 99%, Baseline (adaptation disabled)); skin: 60.4524% (minimum 95%, Baseline (adaptation disabled)); small intestine: 48.1068% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.8258% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 44.8755% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.2237% (minimum 95%, Baseline (adaptation disabled)); stomach: 46.7713% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.4886% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.4760% (minimum 95%, Baseline (adaptation disabled)); tongue: 25.7561% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.2055% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,274,223.4,76,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 2); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); salivary gland: 99 nTPM (protected, limit 2); parathyroid gland: 96.2 nTPM (protected, limit 2); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 2); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 2); pituitary gland: 77 nTPM (vital, limit 1); thymus: 76 nTPM (manageable, limit 5); adipose tissue: 73.4 nTPM (manageable, limit 5); esophagus: 71.4 nTPM (protected, limit 2); spleen: 70.9 nTPM (manageable, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 2); thyroid gland: 62.2 nTPM (manageable, limit 5); rectum: 59 nTPM (protected, limit 2); urinary bladder: 53.4 nTPM (protected, limit 2); lung: 51.7 nTPM (vital, limit 1); skin: 50.7 nTPM (manageable, limit 5); retina: 50.2 nTPM (vital, limit 1); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000131495,NDUFA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.445114,-0.712439,-0.769516
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.3585% (minimum 95%, Missing); adrenal gland: 38.4615% (minimum 99%, Missing); amygdala: 38.3474% (minimum 99%, Missing); basal ganglia: 39.3002% (minimum 99%, Missing); bone marrow: 45.0320% (minimum 99%, Missing); cerebellum: 53.0459% (minimum 99%, Missing); cerebral cortex: 40.1139% (minimum 99%, Missing); choroid plexus: 24.3099% (minimum 99%, Missing); colon: 49.7752% (minimum 97%, Missing); duodenum: 46.9697% (minimum 99%, Missing); esophagus: 52.0484% (minimum 97%, Missing); heart muscle: 28.8533% (minimum 99%, Missing); hippocampal formation: 42.8177% (minimum 99%, Missing); hypothalamus: 41.7790% (minimum 99%, Missing); kidney: 35.4691% (minimum 99%, Missing); liver: 35.3881% (minimum 99%, Missing); lung: 59.9845% (minimum 99%, Missing); lymph node: 54.6159% (minimum 97%, Missing); midbrain: 38.4234% (minimum 99%, Missing); pancreas: 49.5524% (minimum 99%, Missing); parathyroid gland: 44.6172% (minimum 97%, Missing); pituitary gland: 50.1618% (minimum 99%, Missing); rectum: 56.7766% (minimum 97%, Missing); retina: 60.6891% (minimum 99%, Missing); salivary gland: 43.9093% (minimum 97%, Missing); skeletal muscle: 22.0484% (minimum 99%, Missing); skin: 60.4524% (minimum 95%, Missing); small intestine: 48.1068% (minimum 99%, Missing); smooth muscle: 71.8258% (minimum 99%, Missing); spinal cord: 44.8755% (minimum 99%, Missing); spleen: 52.2237% (minimum 95%, Missing); stomach: 46.7713% (minimum 97%, Missing); thymus: 50.4886% (minimum 95%, Missing); thyroid gland: 55.4760% (minimum 95%, Missing); tongue: 25.7561% (minimum 97%, Missing); urinary bladder: 59.2055% (minimum 97%, Missing)",0,6,partial,274,223.4,76,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 2); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); salivary gland: 99 nTPM (protected, limit 2); parathyroid gland: 96.2 nTPM (protected, limit 2); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 2); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 2); pituitary gland: 77 nTPM (vital, limit 1); thymus: 76 nTPM (manageable, limit 5); adipose tissue: 73.4 nTPM (manageable, limit 5); esophagus: 71.4 nTPM (protected, limit 2); spleen: 70.9 nTPM (manageable, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 2); thyroid gland: 62.2 nTPM (manageable, limit 5); rectum: 59 nTPM (protected, limit 2); urinary bladder: 53.4 nTPM (protected, limit 2); lung: 51.7 nTPM (vital, limit 1); skin: 50.7 nTPM (manageable, limit 5); retina: 50.2 nTPM (vital, limit 1); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000131495,NDUFA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.445114,-0.712439,-0.769516
True,compatible,,True,True,False,,0,1,partial,0.2,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000131721,RHOXF2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 98.1651% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.2,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000131721,RHOXF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0407407,0.03,-0.00834862
True,compatible,,True,True,True,,0,1,partial,0.2,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000131721,RHOXF2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.000740741
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,6,partial,0.4,0.1,80.2,"skin: 80.2 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,ENSG00000131738,KRT33B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 22.2222% (minimum 95%, Baseline (adaptation disabled)); cerebral cortex: 33.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skin: 0.2488% (minimum 95%, Baseline (adaptation disabled)); thymus: 13.3333% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,0.4,0.1,80.2,"skin: 80.2 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,ENSG00000131738,KRT33B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.947512,-0.303333,-0.656667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 22.2222% (minimum 80%, Supported); cerebral cortex: 33.3333% (minimum 97%, Supported); esophagus: 66.6667% (minimum 90%, Supported); hippocampal formation: 50.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 90%, Supported); skin: 0.2488% (minimum 95%, Missing); thymus: 13.3333% (minimum 95%, Missing)",0,6,partial,0.4,0.1,80.2,"skin: 80.2 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,ENSG00000131738,KRT33B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.947512,-0.233333,-0.636667
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,41.5,39.4,124.5,"thymus: 124.5 nTPM (manageable, limit 5); bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 2); esophagus: 28.2 nTPM (protected, limit 2); rectum: 19.1 nTPM (protected, limit 2); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 2); small intestine: 16.5 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); spleen: 9.6 nTPM (manageable, limit 5); stomach: 8.6 nTPM (protected, limit 2); smooth muscle: 7.3 nTPM (vital, limit 6); urinary bladder: 5.8 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 2 / cells in basal layer: High (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000131747,TOP2A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.2293% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.5888% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.9605% (minimum 99%, Baseline (adaptation disabled)); colon: 78.7654% (minimum 97%, Baseline (adaptation disabled)); duodenum: 78.3784% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.3478% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.1538% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.3051% (minimum 99%, Baseline (adaptation disabled)); liver: 95.9398% (minimum 99%, Baseline (adaptation disabled)); lung: 94.2393% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.8217% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.6090% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.9602% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 93.8235% (minimum 97%, Baseline (adaptation disabled)); skin: 81.0673% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.4521% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.7328% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9147% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.9210% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.1215% (minimum 97%, Baseline (adaptation disabled)); thymus: 33.8821% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 91.6667% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,41.5,39.4,124.5,"thymus: 124.5 nTPM (manageable, limit 5); bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 2); esophagus: 28.2 nTPM (protected, limit 2); rectum: 19.1 nTPM (protected, limit 2); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 2); small intestine: 16.5 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); spleen: 9.6 nTPM (manageable, limit 5); stomach: 8.6 nTPM (protected, limit 2); smooth muscle: 7.3 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); salivary gland: 4.2 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 2 / cells in basal layer: High (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000131747,TOP2A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.611179,-0.351783,-0.384112
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.2293% (minimum 99%, Missing); bone marrow: 60.5888% (minimum 99%, Missing); colon: 78.7654% (minimum 97%, Missing); duodenum: 78.3784% (minimum 99%, Missing); esophagus: 69.3478% (minimum 97%, Missing); lung: 94.2393% (minimum 99%, Missing); lymph node: 61.8217% (minimum 97%, Missing); rectum: 76.9602% (minimum 97%, Missing); skin: 81.0673% (minimum 95%, Missing); small intestine: 79.4521% (minimum 99%, Missing); smooth muscle: 89.7328% (minimum 95%, Enhanced); spinal cord: 98.9147% (minimum 99%, Missing); spleen: 86.9210% (minimum 95%, Missing); stomach: 88.1215% (minimum 97%, Missing); thymus: 33.8821% (minimum 95%, Missing); urinary bladder: 91.6667% (minimum 97%, Missing)",0,6,partial,41.5,39.4,124.5,"thymus: 124.5 nTPM (manageable, limit 5); bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 2); esophagus: 28.2 nTPM (protected, limit 2); rectum: 19.1 nTPM (protected, limit 2); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 2); small intestine: 16.5 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); spleen: 9.6 nTPM (manageable, limit 5); stomach: 8.6 nTPM (protected, limit 2); smooth muscle: 7.3 nTPM (vital, limit 6); urinary bladder: 5.8 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 2 / cells in basal layer: High (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000131747,TOP2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.611179,-0.351783,-0.384112
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,11,partial,51.4,29.9,16.2,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 2); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (manageable, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 2); liver: 11.9 nTPM (vital, limit 6); salivary gland: 10.7 nTPM (protected, limit 2); urinary bladder: 10.2 nTPM (protected, limit 2); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); rectum: 8.6 nTPM (protected, limit 2); lung: 8.5 nTPM (vital, limit 6); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); stomach: 6.7 nTPM (protected, limit 2); pituitary gland: 6.6 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000131773,KHDRBS3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.4142% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.5750% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.7260% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.3876% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.3269% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3821% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.8286% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.0159% (minimum 99%, Baseline (adaptation disabled)); colon: 92.7184% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.4490% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.2217% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.8575% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.0022% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.4090% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.2002% (minimum 99%, Baseline (adaptation disabled)); liver: 92.7747% (minimum 99%, Baseline (adaptation disabled)); lung: 94.7303% (minimum 99%, Baseline (adaptation disabled)); midbrain: 89.5662% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.4376% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.4403% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.8595% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.6716% (minimum 97%, Baseline (adaptation disabled)); retina: 88.2727% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.4557% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.9533% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.4038% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.7891% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.2302% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.7994% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.4960% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.6344% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 93.7423% (minimum 97%, Baseline (adaptation disabled))",0,11,partial,51.4,29.9,16.2,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 2); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (manageable, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 2); liver: 11.9 nTPM (vital, limit 1); salivary gland: 10.7 nTPM (protected, limit 2); urinary bladder: 10.2 nTPM (protected, limit 2); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); rectum: 8.6 nTPM (protected, limit 2); lung: 8.5 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); stomach: 6.7 nTPM (protected, limit 2); pituitary gland: 6.6 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 2); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000131773,KHDRBS3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.045858,-0.133656,-0.241714
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.4142% (minimum 95%, Missing); adrenal gland: 90.5750% (minimum 99%, Missing); amygdala: 83.7260% (minimum 99%, Missing); basal ganglia: 91.3876% (minimum 99%, Missing); bone marrow: 98.3269% (minimum 99%, Missing); cerebellum: 92.3821% (minimum 99%, Missing); cerebral cortex: 74.8286% (minimum 99%, Missing); choroid plexus: 97.0159% (minimum 99%, Missing); colon: 92.7184% (minimum 97%, Missing); duodenum: 97.4490% (minimum 99%, Missing); heart muscle: 93.8575% (minimum 99%, Missing); hippocampal formation: 84.0022% (minimum 99%, Missing); hypothalamus: 89.4090% (minimum 99%, Missing); kidney: 89.2002% (minimum 99%, Missing); liver: 92.7747% (minimum 95%, Enhanced); lung: 94.7303% (minimum 95%, Enhanced); midbrain: 89.5662% (minimum 99%, Missing); pancreas: 94.4376% (minimum 99%, Missing); parathyroid gland: 95.4403% (minimum 97%, Missing); pituitary gland: 95.8595% (minimum 99%, Missing); rectum: 94.6716% (minimum 97%, Missing); retina: 88.2727% (minimum 99%, Missing); salivary gland: 93.4557% (minimum 97%, Missing); skeletal muscle: 82.9533% (minimum 99%, Missing); small intestine: 96.4038% (minimum 99%, Missing); smooth muscle: 94.7891% (minimum 99%, Missing); spinal cord: 86.2302% (minimum 99%, Missing); stomach: 95.7994% (minimum 97%, Missing); thymus: 94.4960% (minimum 95%, Missing); tongue: 83.6344% (minimum 97%, Missing); urinary bladder: 93.7423% (minimum 97%, Missing)",0,11,partial,51.4,29.9,16.2,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 2); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (manageable, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 2); liver: 11.9 nTPM (vital, limit 6); salivary gland: 10.7 nTPM (protected, limit 2); urinary bladder: 10.2 nTPM (protected, limit 2); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); rectum: 8.6 nTPM (protected, limit 2); lung: 8.5 nTPM (vital, limit 6); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); stomach: 6.7 nTPM (protected, limit 2); pituitary gland: 6.6 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000131773,KHDRBS3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.045858,-0.133656,-0.241714
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,5.6,3.6,4.2,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000131848,ZSCAN5A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 89.0511% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.7273% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.7273% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.8488% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.7293% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.2085% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.4058% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 89.3773% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.1429% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.3773% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.9155% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.4058% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.7059% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.4552% (minimum 99%, Baseline (adaptation disabled)); liver: 90.7063% (minimum 99%, Baseline (adaptation disabled)); lung: 90.0369% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.7293% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.3773% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.7063% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.4058% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.4058% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.1429% (minimum 97%, Baseline (adaptation disabled)); retina: 91.7293% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.7273% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.5248% (minimum 99%, Baseline (adaptation disabled)); skin: 85.3147% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.3773% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.7273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.7757% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.7059% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.3858% (minimum 97%, Baseline (adaptation disabled)); thymus: 87.1429% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.4058% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.0866% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.0369% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,5.6,3.6,4.2,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000131848,ZSCAN5A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0968531,-0.0985714,-0.176667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 89.0511% (minimum 95%, Uncertain); adrenal gland: 88.7273% (minimum 99%, Missing); amygdala: 88.7273% (minimum 99%, Missing); basal ganglia: 83.8488% (minimum 99%, Missing); bone marrow: 91.7293% (minimum 99%, Uncertain); cerebellum: 94.2085% (minimum 99%, Uncertain); cerebral cortex: 88.4058% (minimum 99%, Uncertain); choroid plexus: 81.3333% (minimum 99%, Missing); colon: 89.3773% (minimum 97%, Missing); duodenum: 87.1429% (minimum 99%, Missing); esophagus: 89.3773% (minimum 97%, Uncertain); heart muscle: 85.9155% (minimum 99%, Uncertain); hippocampal formation: 88.4058% (minimum 99%, Missing); hypothalamus: 89.7059% (minimum 99%, Missing); kidney: 87.4552% (minimum 99%, Missing); liver: 90.7063% (minimum 99%, Uncertain); lung: 90.0369% (minimum 99%, Uncertain); lymph node: 91.7293% (minimum 97%, Uncertain); midbrain: 89.3773% (minimum 99%, Missing); pancreas: 90.7063% (minimum 99%, Uncertain); parathyroid gland: 88.4058% (minimum 97%, Missing); pituitary gland: 88.4058% (minimum 99%, Missing); rectum: 87.1429% (minimum 97%, Uncertain); retina: 91.7293% (minimum 99%, Missing); salivary gland: 88.7273% (minimum 97%, Missing); skeletal muscle: 86.5248% (minimum 99%, Uncertain); skin: 85.3147% (minimum 95%, Uncertain); small intestine: 89.3773% (minimum 99%, Missing); smooth muscle: 88.7273% (minimum 99%, Missing); spinal cord: 92.7757% (minimum 99%, Missing); spleen: 89.7059% (minimum 95%, Uncertain); stomach: 91.3858% (minimum 97%, Missing); thymus: 87.1429% (minimum 95%, Missing); thyroid gland: 88.4058% (minimum 95%, Uncertain); tongue: 88.0866% (minimum 97%, Missing); urinary bladder: 90.0369% (minimum 97%, Uncertain)",0,1,partial,5.6,3.6,4.2,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000131848,ZSCAN5A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0968531,-0.0985714,-0.176667
True,compatible,,True,True,False,,0,7,partial,1.6,0.3,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000131864,USP29,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.1176% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.9592% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); liver: 97.9592% (minimum 99%, Baseline (adaptation disabled)); lung: 97.9592% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.1176% (minimum 97%, Baseline (adaptation disabled)); pancreas: 78.6885% (minimum 99%, Baseline (adaptation disabled)); retina: 92.3077% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); skin: 82.7586% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.1176% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.1176% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,1.6,0.3,1,"bone marrow: 1.6 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000131864,USP29,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.122414,-0.0288235,-0.24
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 75.0000% (minimum 95%, Enhanced); choroid plexus: 94.1176% (minimum 99%, Missing); heart muscle: 94.1176% (minimum 95%, Enhanced); pancreas: 78.6885% (minimum 95%, Enhanced); retina: 92.3077% (minimum 99%, Missing); skeletal muscle: 94.1176% (minimum 95%, Enhanced)",0,7,partial,1.6,0.3,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000131864,USP29,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.00959184,-0.2
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland; skin; spleen,ENSG00000131914,LIN28A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"bone marrow: 96.1538% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.0392% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0392% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0392% (minimum 99%, Baseline (adaptation disabled)); retina: 94.3396% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland; skin; spleen,ENSG00000131914,LIN28A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025,0.0303922,0.0103922,-0.0466038
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"duodenum: 98.0392% (minimum 99%, Missing); lung: 98.0392% (minimum 99%, Missing); retina: 94.3396% (minimum 99%, Missing)",0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland; skin; spleen,ENSG00000131914,LIN28A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025,0.05,0.03,-0.0466038
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.6,0.1,0.1,"choroid plexus: 2.6 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000131951,LRRC9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2456% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.2456% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.5517% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.2456% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2456% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.2927% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.5517% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.5517% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2456% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2456% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.8033% (minimum 99%, Baseline (adaptation disabled)); retina: 98.2456% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2456% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2456% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.6,0.1,0.1,"choroid plexus: 2.6 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000131951,LRRC9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0324561,0.0124561,-0.307073
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2456% (minimum 99%, Missing); amygdala: 98.2456% (minimum 99%, Missing); basal ganglia: 96.5517% (minimum 99%, Missing); bone marrow: 98.2456% (minimum 99%, Missing); cerebral cortex: 98.2456% (minimum 99%, Missing); choroid plexus: 68.2927% (minimum 99%, Missing); hippocampal formation: 96.5517% (minimum 99%, Missing); hypothalamus: 96.5517% (minimum 99%, Missing); liver: 98.2456% (minimum 99%, Missing); midbrain: 98.2456% (minimum 99%, Missing); pituitary gland: 91.8033% (minimum 99%, Missing); retina: 98.2456% (minimum 99%, Missing); small intestine: 98.2456% (minimum 99%, Missing); spinal cord: 98.2456% (minimum 99%, Missing)",0,80,unavailable,2.6,0.1,0.1,"choroid plexus: 2.6 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000131951,LRRC9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0324561,0.0124561,-0.307073
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,5.1,5.3,5,"esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000132016,BRME1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.4641% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.9732% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.6154% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.2716% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.0828% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.4792% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.6590% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.1839% (minimum 99%, Baseline (adaptation disabled)); colon: 83.1395% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.2581% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.9592% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.9732% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.6154% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.1446% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.8571% (minimum 99%, Baseline (adaptation disabled)); liver: 90.5063% (minimum 99%, Baseline (adaptation disabled)); lung: 94.7020% (minimum 99%, Baseline (adaptation disabled)); midbrain: 85.1190% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.7113% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.8571% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.9732% (minimum 97%, Baseline (adaptation disabled)); retina: 94.0789% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.2716% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 74.0933% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.1421% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.9452% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.6590% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.4641% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.0828% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 94.0789% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 91.6667% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,5.1,5.3,5,"esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000132016,BRME1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.209067,-0.240408,-0.252887
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 84.6154% (minimum 99%, Missing); basal ganglia: 88.2716% (minimum 99%, Missing); bone marrow: 91.0828% (minimum 95%, Enhanced); cerebellum: 74.4792% (minimum 95%, Enhanced); cerebral cortex: 82.6590% (minimum 99%, Missing); choroid plexus: 82.1839% (minimum 99%, Missing); colon: 83.1395% (minimum 97%, Missing); duodenum: 92.2581% (minimum 99%, Missing); esophagus: 72.9592% (minimum 97%, Missing); hippocampal formation: 84.6154% (minimum 99%, Missing); hypothalamus: 86.1446% (minimum 99%, Missing); kidney: 92.8571% (minimum 99%, Missing); liver: 90.5063% (minimum 95%, Enhanced); lung: 94.7020% (minimum 95%, Enhanced); midbrain: 85.1190% (minimum 99%, Missing); pancreas: 73.7113% (minimum 99%, Missing); pituitary gland: 92.8571% (minimum 99%, Missing); rectum: 95.9732% (minimum 97%, Missing); retina: 94.0789% (minimum 99%, Missing); salivary gland: 88.2716% (minimum 97%, Missing); skin: 74.0933% (minimum 95%, Missing); small intestine: 78.1421% (minimum 99%, Missing); spinal cord: 82.6590% (minimum 99%, Missing); stomach: 91.0828% (minimum 97%, Missing)",0,5,partial,5.1,5.3,5,"esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000132016,BRME1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.209067,-0.240408,-0.252887
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12.8,10.3,9.2,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 2); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); lung: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 2); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132122,SPATA6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.3382% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.1702% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.5028% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.1818% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.2000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.7481% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8483% (minimum 99%, Baseline (adaptation disabled)); colon: 90.6716% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.9219% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.6416% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.0455% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.5028% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.5028% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.3382% (minimum 99%, Baseline (adaptation disabled)); liver: 96.8127% (minimum 99%, Baseline (adaptation disabled)); lung: 89.5028% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.8580% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.7256% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.5254% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.5127% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.4130% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.7481% (minimum 97%, Baseline (adaptation disabled)); retina: 79.1531% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.8483% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.6203% (minimum 99%, Baseline (adaptation disabled)); skin: 91.8715% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.8224% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.8715% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.2033% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.1034% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.2033% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.1860% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.0830% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.2821% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.3382% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,12.8,10.3,9.2,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 2); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); lung: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 2); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132122,SPATA6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.10917,-0.144873,-0.198469
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.3382% (minimum 95%, Missing); adrenal gland: 86.1702% (minimum 99%, Missing); amygdala: 90.0000% (minimum 99%, Missing); basal ganglia: 90.5028% (minimum 99%, Missing); bone marrow: 98.1818% (minimum 99%, Missing); cerebellum: 97.2000% (minimum 99%, Missing); cerebral cortex: 92.7481% (minimum 99%, Missing); choroid plexus: 88.8483% (minimum 99%, Missing); colon: 90.6716% (minimum 97%, Missing); duodenum: 94.9219% (minimum 99%, Missing); esophagus: 93.6416% (minimum 97%, Missing); heart muscle: 92.0455% (minimum 99%, Missing); hippocampal formation: 89.5028% (minimum 99%, Missing); hypothalamus: 90.5028% (minimum 99%, Missing); kidney: 89.3382% (minimum 99%, Missing); liver: 96.8127% (minimum 99%, Missing); lung: 89.5028% (minimum 99%, Missing); lymph node: 95.8580% (minimum 97%, Missing); midbrain: 87.7256% (minimum 99%, Missing); pancreas: 91.5254% (minimum 99%, Missing); parathyroid gland: 82.5127% (minimum 97%, Missing); pituitary gland: 85.4130% (minimum 99%, Missing); rectum: 92.7481% (minimum 97%, Missing); retina: 79.1531% (minimum 99%, Missing); salivary gland: 88.8483% (minimum 97%, Missing); skeletal muscle: 96.6203% (minimum 99%, Missing); skin: 91.8715% (minimum 95%, Missing); small intestine: 93.8224% (minimum 99%, Missing); smooth muscle: 91.8715% (minimum 99%, Missing); spinal cord: 88.2033% (minimum 99%, Missing); spleen: 93.1034% (minimum 95%, Missing); stomach: 88.2033% (minimum 97%, Missing); thymus: 94.1860% (minimum 95%, Missing); thyroid gland: 84.0830% (minimum 95%, Missing); tongue: 93.2821% (minimum 97%, Missing); urinary bladder: 89.3382% (minimum 97%, Missing)",0,80,unavailable,12.8,10.3,9.2,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 2); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); lung: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 2); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132122,SPATA6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.10917,-0.144873,-0.198469
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,4.9,3.6,2.8,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000132141,CCT6B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.4543% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.3146% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2358% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.9913% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.4727% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.4727% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.8701% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.6312% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.3936% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.3936% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.9146% (minimum 99%, Baseline (adaptation disabled)); liver: 96.2294% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.7654% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.9217% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.8435% (minimum 99%, Baseline (adaptation disabled)); retina: 98.2358% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8701% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7107% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4543% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,4.9,3.6,2.8,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000132141,CCT6B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0276536,0.00145123,-0.0284615
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.4543% (minimum 99%, Missing); amygdala: 98.3146% (minimum 99%, Missing); basal ganglia: 98.2358% (minimum 99%, Missing); bone marrow: 96.9913% (minimum 99%, Missing); cerebral cortex: 98.4727% (minimum 99%, Missing); choroid plexus: 98.4727% (minimum 99%, Missing); duodenum: 98.8701% (minimum 99%, Missing); heart muscle: 98.6312% (minimum 99%, Uncertain); hippocampal formation: 98.3936% (minimum 99%, Missing); hypothalamus: 98.3936% (minimum 99%, Missing); kidney: 96.9146% (minimum 99%, Missing); liver: 96.2294% (minimum 99%, Missing); midbrain: 97.7654% (minimum 99%, Missing); pancreas: 97.9217% (minimum 99%, Missing); pituitary gland: 97.8435% (minimum 99%, Missing); retina: 98.2358% (minimum 99%, Missing); skeletal muscle: 96.1538% (minimum 99%, Uncertain); small intestine: 98.8701% (minimum 99%, Missing); smooth muscle: 98.7107% (minimum 99%, Uncertain); spinal cord: 97.4543% (minimum 99%, Missing)",0,6,partial,4.9,3.6,2.8,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000132141,CCT6B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0276536,0.00145123,-0.0284615
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,9.4,9.9,9.7,"lymph node: 9.9 nTPM (protected, limit 2); thymus: 9.7 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); tongue: 7.7 nTPM (protected, limit 2); spleen: 7.4 nTPM (manageable, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 2); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 2); liver: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000132436,FIGNL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3448% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.8310% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.5556% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.3878% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.5455% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.0778% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.5767% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.6957% (minimum 99%, Baseline (adaptation disabled)); colon: 63.3540% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.7143% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.2553% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 73.9130% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.3813% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.9130% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.5556% (minimum 99%, Baseline (adaptation disabled)); liver: 69.3878% (minimum 99%, Baseline (adaptation disabled)); lung: 76.1194% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.7463% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.4526% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.0698% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.9130% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.3150% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.5767% (minimum 97%, Baseline (adaptation disabled)); retina: 52.5773% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.9130% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.5767% (minimum 99%, Baseline (adaptation disabled)); skin: 55.1351% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.9630% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 52.0408% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.8571% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.9545% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.3287% (minimum 97%, Baseline (adaptation disabled)); thymus: 51.2563% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 74.4526% (minimum 95%, Baseline (adaptation disabled)); tongue: 56.9832% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,9.4,9.9,9.7,"lymph node: 9.9 nTPM (protected, limit 2); thymus: 9.7 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); tongue: 7.7 nTPM (protected, limit 2); spleen: 7.4 nTPM (manageable, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 2); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 2); liver: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000132436,FIGNL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.437437,-0.462537,-0.469592
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3448% (minimum 90%, Approved); adrenal gland: 71.8310% (minimum 99%, Missing); amygdala: 75.5556% (minimum 99%, Missing); basal ganglia: 69.3878% (minimum 99%, Missing); bone marrow: 54.5455% (minimum 99%, Missing); cerebellum: 61.0778% (minimum 99%, Missing); cerebral cortex: 62.5767% (minimum 99%, Missing); choroid plexus: 88.6957% (minimum 99%, Missing); colon: 63.3540% (minimum 97%, Missing); duodenum: 60.7143% (minimum 99%, Missing); esophagus: 54.2553% (minimum 97%, Missing); heart muscle: 73.9130% (minimum 99%, Missing); hippocampal formation: 73.3813% (minimum 99%, Missing); hypothalamus: 73.9130% (minimum 99%, Missing); kidney: 75.5556% (minimum 99%, Missing); liver: 69.3878% (minimum 99%, Missing); lung: 76.1194% (minimum 99%, Missing); lymph node: 50.7463% (minimum 97%, Missing); midbrain: 74.4526% (minimum 99%, Missing); pancreas: 79.0698% (minimum 99%, Missing); parathyroid gland: 73.9130% (minimum 97%, Missing); pituitary gland: 80.3150% (minimum 99%, Missing); rectum: 62.5767% (minimum 97%, Missing); retina: 52.5773% (minimum 99%, Missing); salivary gland: 73.9130% (minimum 97%, Missing); skeletal muscle: 62.5767% (minimum 99%, Missing); skin: 55.1351% (minimum 95%, Missing); small intestine: 62.9630% (minimum 99%, Missing); smooth muscle: 52.0408% (minimum 98%, Approved); spinal cord: 72.8571% (minimum 99%, Missing); spleen: 57.9545% (minimum 95%, Missing); stomach: 71.3287% (minimum 97%, Missing); thymus: 51.2563% (minimum 95%, Missing); thyroid gland: 74.4526% (minimum 95%, Missing); tongue: 56.9832% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,1,partial,9.4,9.9,9.7,"lymph node: 9.9 nTPM (protected, limit 2); thymus: 9.7 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); tongue: 7.7 nTPM (protected, limit 2); spleen: 7.4 nTPM (manageable, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 2); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 2); liver: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000132436,FIGNL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.437437,-0.462537,-0.464227
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000132446,FTHL17,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000132446,FTHL17,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.024359,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000132446,FTHL17,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.024359,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.6,1.8,0.1,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000132464,ENAM,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 98.6486% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 53.6765% (minimum 99%, Baseline (adaptation disabled)); kidney: 45.9119% (minimum 99%, Baseline (adaptation disabled)); liver: 93.5897% (minimum 99%, Baseline (adaptation disabled)); lung: 96.0526% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.5926% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.4051% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.3333% (minimum 99%, Baseline (adaptation disabled)); retina: 98.6486% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 60.8333% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6486% (minimum 99%, Baseline (adaptation disabled)); stomach: 81.1111% (minimum 97%, Baseline (adaptation disabled)); tongue: 80.2198% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.6,1.8,0.1,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000132464,ENAM,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0364865,-0.167802,-0.530881
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 98.6486% (minimum 99%, Missing); heart muscle: 53.6765% (minimum 99%, Missing); kidney: 45.9119% (minimum 99%, Missing); liver: 93.5897% (minimum 99%, Missing); lung: 96.0526% (minimum 99%, Missing); pancreas: 67.5926% (minimum 99%, Missing); parathyroid gland: 92.4051% (minimum 97%, Missing); pituitary gland: 97.3333% (minimum 99%, Missing); retina: 98.6486% (minimum 99%, Missing); skeletal muscle: 60.8333% (minimum 99%, Missing); small intestine: 97.3333% (minimum 99%, Missing); smooth muscle: 98.6486% (minimum 99%, Missing); stomach: 81.1111% (minimum 97%, Missing); tongue: 80.2198% (minimum 97%, Missing)",0,80,unavailable,8.6,1.8,0.1,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000132464,ENAM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0364865,-0.167802,-0.530881
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.4,0.3,2.6,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000132554,RGS22,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5124% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.6755% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.3030% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.6755% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.1878% (minimum 99%, Baseline (adaptation disabled)); lung: 97.3856% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.1878% (minimum 99%, Baseline (adaptation disabled)); retina: 98.5124% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.5450% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,6.4,0.3,2.6,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000132554,RGS22,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00819936,0.0249917,-0.0869697
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5124% (minimum 99%, Missing); basal ganglia: 98.6755% (minimum 99%, Missing); choroid plexus: 90.3030% (minimum 99%, Missing); hippocampal formation: 98.6755% (minimum 99%, Missing); hypothalamus: 98.1878% (minimum 99%, Missing); lung: 97.3856% (minimum 99%, Missing); pituitary gland: 98.1878% (minimum 99%, Missing); retina: 98.5124% (minimum 99%, Missing); smooth muscle: 97.5450% (minimum 99%, Missing)",0,80,unavailable,6.4,0.3,2.6,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000132554,RGS22,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00819936,0.0249917,-0.0869697
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000132631,SCP2D1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000132631,SCP2D1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000132631,SCP2D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,4.9,1,"urinary bladder: 4.9 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000132681,ATP1A4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 98.1366% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.1579% (minimum 97%, Baseline (adaptation disabled)); retina: 86.8132% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 84.4920% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.7500% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.0476% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 76.3285% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,4.9,1,"urinary bladder: 4.9 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000132681,ATP1A4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00952381,-0.206715,-0.14508
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 98.1366% (minimum 99%, Missing); lymph node: 83.1579% (minimum 97%, Missing); retina: 86.8132% (minimum 99%, Missing); skeletal muscle: 84.4920% (minimum 99%, Missing); small intestine: 98.7500% (minimum 99%, Missing); spleen: 94.0476% (minimum 95%, Missing); urinary bladder: 76.3285% (minimum 97%, Missing)",0,80,unavailable,2.9,4.9,1,"urinary bladder: 4.9 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000132681,ATP1A4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00952381,-0.206715,-0.14508
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.4,2.9,2,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132749,TESMIN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.2659% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 87.3288% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.6460% (minimum 99%, Baseline (adaptation disabled)); colon: 95.5056% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.5143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.2659% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.4444% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.8887% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.2264% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.6848% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.6197% (minimum 97%, Baseline (adaptation disabled)); retina: 97.3282% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.5909% (minimum 97%, Baseline (adaptation disabled)); small intestine: 97.5143% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,7.4,2.9,2,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132749,TESMIN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0122642,-0.0238033,-0.116712
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.2659% (minimum 99%, Missing); bone marrow: 87.3288% (minimum 99%, Missing); choroid plexus: 98.6460% (minimum 99%, Missing); colon: 95.5056% (minimum 97%, Missing); duodenum: 97.5143% (minimum 99%, Missing); hypothalamus: 98.2659% (minimum 99%, Missing); kidney: 94.4444% (minimum 99%, Missing); pancreas: 97.8887% (minimum 99%, Missing); parathyroid gland: 96.2264% (minimum 97%, Missing); pituitary gland: 95.6848% (minimum 99%, Missing); rectum: 94.6197% (minimum 97%, Missing); retina: 97.3282% (minimum 99%, Missing); salivary gland: 96.5909% (minimum 97%, Missing); small intestine: 97.5143% (minimum 99%, Missing)",0,80,unavailable,7.4,2.9,2,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132749,TESMIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0122642,-0.0238033,-0.116712
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,19.7,0.6,0.1,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000132932,ATP8A2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.5238% (minimum 99%, Baseline (adaptation disabled)); amygdala: 34.7222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 33.7838% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 11.2613% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 14.6199% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.2069% (minimum 99%, Baseline (adaptation disabled)); colon: 89.2857% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.1538% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 33.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 19.6850% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.2857% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.1538% (minimum 97%, Baseline (adaptation disabled)); midbrain: 31.6456% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.5926% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 14.4509% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.1538% (minimum 97%, Baseline (adaptation disabled)); retina: 14.8810% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 92.5926% (minimum 99%, Baseline (adaptation disabled)); small intestine: 89.2857% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.8182% (minimum 99%, Baseline (adaptation disabled)); stomach: 80.6452% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.5926% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,19.7,0.6,0.1,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000132932,ATP8A2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0115385,-0.163548,-0.877387
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.5238% (minimum 99%, Missing); amygdala: 34.7222% (minimum 99%, Missing); basal ganglia: 33.7838% (minimum 99%, Missing); cerebellum: 11.2613% (minimum 99%, Missing); cerebral cortex: 14.6199% (minimum 99%, Missing); choroid plexus: 86.2069% (minimum 99%, Missing); duodenum: 96.1538% (minimum 99%, Missing); hippocampal formation: 33.3333% (minimum 99%, Missing); hypothalamus: 19.6850% (minimum 99%, Missing); kidney: 89.2857% (minimum 95%, Enhanced); lung: 83.3333% (minimum 95%, Enhanced); lymph node: 96.1538% (minimum 97%, Missing); midbrain: 31.6456% (minimum 99%, Missing); pancreas: 92.5926% (minimum 99%, Missing); pituitary gland: 14.4509% (minimum 99%, Missing); retina: 14.8810% (minimum 99%, Missing); skeletal muscle: 92.5926% (minimum 95%, Enhanced); small intestine: 89.2857% (minimum 99%, Missing); spinal cord: 56.8182% (minimum 99%, Missing); stomach: 80.6452% (minimum 97%, Missing)",0,3,partial,19.7,0.6,0.1,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000132932,ATP8A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0115385,-0.163548,-0.877387
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,12.1,10,9.8,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); spleen: 7.3 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 2); urinary bladder: 6.9 nTPM (protected, limit 2); liver: 6.7 nTPM (vital, limit 1); adipose tissue: 6.7 nTPM (manageable, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); duodenum: 6 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); parathyroid gland: 5.3 nTPM (protected, limit 2); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000132950,ZMYM5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.2109% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.9175% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.3701% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.6719% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.2299% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.6719% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.6547% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.3077% (minimum 99%, Baseline (adaptation disabled)); colon: 79.9296% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.0941% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.4153% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.3620% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.3268% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.6719% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.2759% (minimum 99%, Baseline (adaptation disabled)); liver: 77.2109% (minimum 99%, Baseline (adaptation disabled)); lung: 77.7397% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.4190% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.6412% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.0714% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 81.0714% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.8467% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.0941% (minimum 97%, Baseline (adaptation disabled)); retina: 72.0635% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.2120% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 79.0941% (minimum 99%, Baseline (adaptation disabled)); skin: 74.9175% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.0069% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 77.4744% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.1502% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.1745% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.8462% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 73.2258% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.4153% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.6892% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,12.1,10,9.8,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); spleen: 7.3 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 2); urinary bladder: 6.9 nTPM (protected, limit 2); liver: 6.7 nTPM (vital, limit 1); adipose tissue: 6.7 nTPM (manageable, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); duodenum: 6 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); parathyroid gland: 5.3 nTPM (protected, limit 2); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000132950,ZMYM5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.251538,-0.27581,-0.337701
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.2109% (minimum 95%, Uncertain); adrenal gland: 74.9175% (minimum 99%, Missing); amygdala: 89.3701% (minimum 99%, Missing); basal ganglia: 88.6719% (minimum 99%, Missing); bone marrow: 65.2299% (minimum 99%, Missing); cerebellum: 88.6719% (minimum 99%, Missing); cerebral cortex: 81.6547% (minimum 99%, Missing); choroid plexus: 87.3077% (minimum 99%, Missing); colon: 79.9296% (minimum 97%, Missing); duodenum: 79.0941% (minimum 99%, Missing); esophagus: 75.4153% (minimum 97%, Missing); heart muscle: 81.3620% (minimum 99%, Missing); hippocampal formation: 88.3268% (minimum 99%, Missing); hypothalamus: 88.6719% (minimum 99%, Missing); kidney: 78.2759% (minimum 99%, Missing); liver: 77.2109% (minimum 99%, Missing); lung: 77.7397% (minimum 99%, Missing); lymph node: 69.4190% (minimum 97%, Missing); midbrain: 86.6412% (minimum 99%, Missing); pancreas: 81.0714% (minimum 99%, Missing); parathyroid gland: 81.0714% (minimum 97%, Missing); pituitary gland: 82.8467% (minimum 99%, Missing); rectum: 79.0941% (minimum 97%, Missing); retina: 72.0635% (minimum 99%, Missing); salivary gland: 80.2120% (minimum 97%, Missing); skeletal muscle: 79.0941% (minimum 99%, Missing); skin: 74.9175% (minimum 95%, Missing); small intestine: 78.0069% (minimum 99%, Missing); smooth muscle: 77.4744% (minimum 99%, Missing); spinal cord: 83.1502% (minimum 99%, Missing); spleen: 75.6667% (minimum 95%, Missing); stomach: 76.1745% (minimum 97%, Missing); thymus: 69.8462% (minimum 95%, Missing); thyroid gland: 73.2258% (minimum 95%, Missing); tongue: 75.4153% (minimum 97%, Missing); urinary bladder: 76.6892% (minimum 97%, Missing)",0,3,partial,12.1,10,9.8,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); spleen: 7.3 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 2); urinary bladder: 6.9 nTPM (protected, limit 2); liver: 6.7 nTPM (vital, limit 1); adipose tissue: 6.7 nTPM (manageable, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); duodenum: 6 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); parathyroid gland: 5.3 nTPM (protected, limit 2); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000132950,ZMYM5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.251538,-0.27581,-0.337701
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,42.8,16.2,6.9,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 2); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thymus: 6.9 nTPM (manageable, limit 5); thyroid gland: 6.3 nTPM (manageable, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); cerebellum: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); urinary bladder: 4.5 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132953,XPO4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.8235% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.1579% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.9221% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 37.2671% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.0748% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.1818% (minimum 99%, Baseline (adaptation disabled)); colon: 57.1429% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.5000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 56.0748% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 36.5854% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.0459% (minimum 99%, Baseline (adaptation disabled)); liver: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 50.4202% (minimum 99%, Baseline (adaptation disabled)); lymph node: 45.4545% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.9231% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.4059% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 48.7805% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.4157% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.1739% (minimum 97%, Baseline (adaptation disabled)); retina: 31.2500% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 12.2951% (minimum 99%, Baseline (adaptation disabled)); skin: 52.1739% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.8557% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 52.6316% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.9655% (minimum 99%, Baseline (adaptation disabled)); spleen: 51.2821% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.6038% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.5116% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.7805% (minimum 95%, Baseline (adaptation disabled)); tongue: 27.0270% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,42.8,16.2,6.9,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 2); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thymus: 6.9 nTPM (manageable, limit 5); thyroid gland: 6.3 nTPM (manageable, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); cerebellum: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); urinary bladder: 4.5 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132953,XPO4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.484884,-0.69973,-0.867049
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.8235% (minimum 95%, Missing); adrenal gland: 63.1579% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 77.9221% (minimum 99%, Missing); bone marrow: 37.2671% (minimum 99%, Missing); cerebellum: 56.0748% (minimum 99%, Missing); cerebral cortex: 60.0000% (minimum 99%, Missing); choroid plexus: 68.1818% (minimum 99%, Missing); colon: 57.1429% (minimum 97%, Missing); duodenum: 62.5000% (minimum 99%, Missing); esophagus: 56.0748% (minimum 97%, Missing); heart muscle: 36.5854% (minimum 99%, Missing); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 80.0000% (minimum 99%, Missing); kidney: 55.0459% (minimum 99%, Missing); liver: 60.0000% (minimum 99%, Missing); lung: 50.4202% (minimum 99%, Missing); lymph node: 45.4545% (minimum 97%, Missing); midbrain: 76.9231% (minimum 99%, Missing); pancreas: 59.4059% (minimum 99%, Missing); parathyroid gland: 48.7805% (minimum 97%, Missing); pituitary gland: 67.4157% (minimum 99%, Missing); rectum: 52.1739% (minimum 97%, Missing); retina: 31.2500% (minimum 99%, Missing); salivary gland: 62.5000% (minimum 97%, Missing); skeletal muscle: 12.2951% (minimum 99%, Missing); skin: 52.1739% (minimum 95%, Missing); small intestine: 61.8557% (minimum 99%, Missing); smooth muscle: 52.6316% (minimum 99%, Missing); spinal cord: 68.9655% (minimum 99%, Missing); spleen: 51.2821% (minimum 95%, Missing); stomach: 56.6038% (minimum 97%, Missing); thymus: 46.5116% (minimum 95%, Missing); thyroid gland: 48.7805% (minimum 95%, Missing); tongue: 27.0270% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",0,80,unavailable,42.8,16.2,6.9,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 2); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 2); thymus: 6.9 nTPM (manageable, limit 5); thyroid gland: 6.3 nTPM (manageable, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); cerebellum: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); colon: 4.5 nTPM (protected, limit 2); urinary bladder: 4.5 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132953,XPO4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.484884,-0.69973,-0.867049
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132958,TPTE2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.6111% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.2603% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6111% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.2603% (minimum 99%, Baseline (adaptation disabled)); duodenum: 93.4211% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.6111% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2603% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6111% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6111% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.9459% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.6111% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.6111% (minimum 99%, Baseline (adaptation disabled)); retina: 93.4211% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.9459% (minimum 99%, Baseline (adaptation disabled)); small intestine: 93.4211% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6111% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.6111% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132958,TPTE2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0226027,-0.0105405,-0.0557895
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.6111% (minimum 99%, Missing); amygdala: 97.2603% (minimum 99%, Missing); basal ganglia: 94.6667% (minimum 99%, Missing); bone marrow: 98.6111% (minimum 99%, Missing); cerebellum: 94.6667% (minimum 99%, Missing); cerebral cortex: 94.6667% (minimum 99%, Missing); choroid plexus: 97.2603% (minimum 99%, Missing); duodenum: 93.4211% (minimum 99%, Missing); hippocampal formation: 98.6111% (minimum 99%, Missing); hypothalamus: 97.2603% (minimum 99%, Missing); kidney: 98.6111% (minimum 99%, Missing); liver: 98.6111% (minimum 99%, Missing); lymph node: 95.9459% (minimum 97%, Missing); midbrain: 98.6111% (minimum 99%, Missing); pituitary gland: 98.6111% (minimum 99%, Missing); retina: 93.4211% (minimum 99%, Missing); skeletal muscle: 95.9459% (minimum 99%, Missing); small intestine: 93.4211% (minimum 99%, Missing); smooth muscle: 98.6111% (minimum 99%, Missing); spinal cord: 98.6111% (minimum 99%, Missing)",0,80,unavailable,0.5,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000132958,TPTE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0226027,-0.0105405,-0.0557895
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,0.3,0.1,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000132972,RNF17,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 98.7448% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.3,0.1,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000132972,RNF17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.0257806,-0.0025523
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 98.7448% (minimum 99%, Missing)",0,2,partial,0.3,0.1,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000132972,RNF17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.0257806,-0.0025523
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,10.3,17,1.9,"salivary gland: 17 nTPM (protected, limit 2); pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); urinary bladder: 6.8 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000133019,CHRM3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 91.4894% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.1379% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.5556% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 30.7143% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7273% (minimum 99%, Baseline (adaptation disabled)); colon: 39.0909% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.4386% (minimum 99%, Baseline (adaptation disabled)); esophagus: 37.3913% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.4894% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.1875% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.4386% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.6296% (minimum 99%, Baseline (adaptation disabled)); liver: 91.4894% (minimum 99%, Baseline (adaptation disabled)); lung: 79.6296% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.4894% (minimum 99%, Baseline (adaptation disabled)); pancreas: 29.4521% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.5833% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 89.5833% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.5634% (minimum 97%, Baseline (adaptation disabled)); retina: 72.8814% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 20.1878% (minimum 97%, Baseline (adaptation disabled)); skin: 78.1818% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.4386% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 51.8072% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.5556% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 46.7391% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 69.3548% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 38.7387% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,10.3,17,1.9,"salivary gland: 17 nTPM (protected, limit 2); pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); urinary bladder: 6.8 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000133019,CHRM3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.256452,-0.768122,-0.695479
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 91.4894% (minimum 99%, Missing); amygdala: 71.6667% (minimum 99%, Missing); basal ganglia: 74.1379% (minimum 99%, Missing); bone marrow: 95.5556% (minimum 98%, Approved); cerebral cortex: 30.7143% (minimum 99%, Missing); choroid plexus: 97.7273% (minimum 99%, Missing); colon: 39.0909% (minimum 97%, Missing); duodenum: 75.4386% (minimum 99%, Missing); esophagus: 37.3913% (minimum 97%, Missing); heart muscle: 91.4894% (minimum 98%, Approved); hippocampal formation: 67.1875% (minimum 99%, Missing); hypothalamus: 75.4386% (minimum 99%, Missing); kidney: 79.6296% (minimum 99%, Missing); liver: 91.4894% (minimum 99%, Missing); lung: 79.6296% (minimum 99%, Missing); midbrain: 91.4894% (minimum 99%, Missing); pancreas: 29.4521% (minimum 99%, Missing); parathyroid gland: 89.5833% (minimum 95%, Approved); pituitary gland: 89.5833% (minimum 99%, Missing); rectum: 60.5634% (minimum 97%, Missing); retina: 72.8814% (minimum 99%, Missing); salivary gland: 20.1878% (minimum 97%, Missing); skin: 78.1818% (minimum 95%, Missing); small intestine: 75.4386% (minimum 99%, Missing); smooth muscle: 51.8072% (minimum 99%, Missing); spinal cord: 95.5556% (minimum 99%, Missing); spleen: 86.0000% (minimum 90%, Approved); stomach: 46.7391% (minimum 97%, Missing); thyroid gland: 69.3548% (minimum 95%, Missing); urinary bladder: 38.7387% (minimum 97%, Missing)",0,2,partial,10.3,17,1.9,"salivary gland: 17 nTPM (protected, limit 2); pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); urinary bladder: 6.8 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000133019,CHRM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.256452,-0.768122,-0.695479
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,11.9,21.5,0.6,"parathyroid gland: 21.5 nTPM (protected, limit 12); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 6); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 6); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000133101,CCNA1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8736% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.8320% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.9087% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.5309% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.8046% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.5963% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.4352% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.3665% (minimum 99%, Baseline (adaptation disabled)); lung: 98.3811% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.1071% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.6070% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.8046% (minimum 99%, Baseline (adaptation disabled)); retina: 98.8736% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.5037% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.9091% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.8934% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,11.9,21.5,0.6,"parathyroid gland: 21.5 nTPM (protected, limit 2); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000133101,CCNA1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0424623,-0.18393,-0.120913
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 92.8320% (minimum 99%, Missing); basal ganglia: 86.9087% (minimum 99%, Missing); cerebral cortex: 90.8046% (minimum 95%, Enhanced); choroid plexus: 90.5963% (minimum 99%, Missing); hippocampal formation: 91.4352% (minimum 99%, Missing); hypothalamus: 89.3665% (minimum 99%, Missing); midbrain: 96.1071% (minimum 99%, Missing); parathyroid gland: 78.6070% (minimum 80%, Enhanced); pituitary gland: 90.8046% (minimum 99%, Missing); retina: 98.8736% (minimum 99%, Missing); smooth muscle: 90.9091% (minimum 95%, Enhanced); spinal cord: 97.8934% (minimum 99%, Missing)",0,4,partial,11.9,21.5,0.6,"parathyroid gland: 21.5 nTPM (protected, limit 12); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 6); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 6); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000133101,CCNA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0449622,-0.0139303,-0.120913
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7,6.6,8,"thymus: 8 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 2); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 2); spinal cord: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); basal ganglia: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); hypothalamus: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000133111,RFXAP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.1111% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 61.1111% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.6822% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.8000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.5294% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.3817% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.6471% (minimum 99%, Baseline (adaptation disabled)); colon: 57.3913% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.7500% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.4737% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.6822% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.2642% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.3469% (minimum 99%, Baseline (adaptation disabled)); liver: 72.5275% (minimum 99%, Baseline (adaptation disabled)); lung: 61.6822% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.6822% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.4595% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.3810% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.4595% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.2642% (minimum 97%, Baseline (adaptation disabled)); retina: 55.4622% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.4071% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.6822% (minimum 99%, Baseline (adaptation disabled)); skin: 66.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.5505% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 54.5455% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.3913% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.3913% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.6822% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.2055% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.6585% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.4737% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.8571% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7,6.6,8,"thymus: 8 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 2); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 2); spinal cord: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); basal ganglia: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); hypothalamus: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000133111,RFXAP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.497945,-0.47,-0.504706
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.1111% (minimum 95%, Missing); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 61.1111% (minimum 99%, Missing); basal ganglia: 61.6822% (minimum 99%, Missing); bone marrow: 52.8000% (minimum 99%, Missing); cerebellum: 48.5294% (minimum 99%, Missing); cerebral cortex: 50.3817% (minimum 99%, Missing); choroid plexus: 77.6471% (minimum 99%, Missing); colon: 57.3913% (minimum 97%, Missing); duodenum: 68.7500% (minimum 99%, Missing); esophagus: 69.4737% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 61.6822% (minimum 99%, Missing); hypothalamus: 62.2642% (minimum 99%, Missing); kidney: 67.3469% (minimum 99%, Missing); liver: 72.5275% (minimum 99%, Missing); lung: 61.6822% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 61.6822% (minimum 99%, Missing); pancreas: 59.4595% (minimum 99%, Missing); parathyroid gland: 52.3810% (minimum 97%, Missing); pituitary gland: 59.4595% (minimum 99%, Missing); rectum: 62.2642% (minimum 97%, Missing); retina: 55.4622% (minimum 99%, Missing); salivary gland: 58.4071% (minimum 97%, Missing); skeletal muscle: 61.6822% (minimum 99%, Missing); skin: 66.0000% (minimum 95%, Missing); small intestine: 60.5505% (minimum 99%, Missing); smooth muscle: 54.5455% (minimum 99%, Missing); spinal cord: 57.3913% (minimum 99%, Missing); spleen: 57.3913% (minimum 95%, Missing); stomach: 61.6822% (minimum 97%, Missing); thymus: 45.2055% (minimum 95%, Missing); thyroid gland: 53.6585% (minimum 95%, Missing); tongue: 69.4737% (minimum 97%, Missing); urinary bladder: 62.8571% (minimum 97%, Missing)",0,80,unavailable,7,6.6,8,"thymus: 8 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 2); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 2); spinal cord: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); basal ganglia: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); hypothalamus: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000133111,RFXAP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.497945,-0.47,-0.504706
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,13.1,19.7,18.2,"esophagus: 19.7 nTPM (protected, limit 12); pancreas: 13.1 nTPM (vital, limit 6); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin; thymus; tonsil,ENSG00000133477,FAM83F,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 97.3039% (minimum 99%, Baseline (adaptation disabled)); colon: 88.4187% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.7570% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.8350% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.4327% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.0550% (minimum 99%, Baseline (adaptation disabled)); liver: 93.4118% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.1894% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.4187% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.0660% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.7570% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 83.2285% (minimum 97%, Baseline (adaptation disabled)); skin: 68.5665% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.2887% (minimum 99%, Baseline (adaptation disabled)); stomach: 85.7451% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 87.4449% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.0758% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,13.1,19.7,18.2,"esophagus: 19.7 nTPM (protected, limit 2); skin: 18.2 nTPM (manageable, limit 5); pancreas: 13.1 nTPM (vital, limit 1); salivary gland: 8 nTPM (protected, limit 2); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); thyroid gland: 5.7 nTPM (manageable, limit 5); parathyroid gland: 5.2 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin; thymus; tonsil,ENSG00000133477,FAM83F,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.264335,-0.30165,-0.238106
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 88.4187% (minimum 97%, Missing); duodenum: 92.7570% (minimum 99%, Missing); esophagus: 66.8350% (minimum 80%, Enhanced); heart muscle: 95.4327% (minimum 99%, Missing); kidney: 91.0550% (minimum 99%, Missing); liver: 93.4118% (minimum 95%, Enhanced); pancreas: 75.1894% (minimum 95%, Enhanced); pituitary gland: 97.0660% (minimum 99%, Missing); rectum: 92.7570% (minimum 97%, Missing); small intestine: 84.2887% (minimum 99%, Missing); stomach: 85.7451% (minimum 97%, Missing); urinary bladder: 94.0758% (minimum 97%, Missing)",0,2,partial,13.1,19.7,18.2,"esophagus: 19.7 nTPM (protected, limit 12); pancreas: 13.1 nTPM (vital, limit 6); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin; thymus; tonsil,ENSG00000133477,FAM83F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0302469,-0.13165,-0.198106
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,13.6,2.9,2.3,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus,ENSG00000133640,LRRIQ1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5414% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.5926% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.2857% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.7742% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 52.4476% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.6842% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.7574% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.2093% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.7574% (minimum 99%, Baseline (adaptation disabled)); lung: 85.7143% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.5414% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0392% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.7989% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.0245% (minimum 99%, Baseline (adaptation disabled)); retina: 63.8298% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.7742% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 86.7052% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,13.6,2.9,2.3,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus,ENSG00000133640,LRRIQ1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.082948,-0.132011,-0.465524
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5414% (minimum 99%, Missing); amygdala: 92.5926% (minimum 99%, Missing); basal ganglia: 89.2857% (minimum 99%, Missing); cerebral cortex: 96.7742% (minimum 99%, Missing); choroid plexus: 52.4476% (minimum 99%, Missing); heart muscle: 98.6842% (minimum 99%, Missing); hippocampal formation: 88.7574% (minimum 99%, Missing); hypothalamus: 87.2093% (minimum 99%, Missing); kidney: 88.7574% (minimum 99%, Missing); lung: 85.7143% (minimum 99%, Missing); midbrain: 95.5414% (minimum 99%, Missing); pancreas: 98.0392% (minimum 99%, Missing); parathyroid gland: 83.7989% (minimum 97%, Missing); pituitary gland: 92.0245% (minimum 99%, Missing); retina: 63.8298% (minimum 99%, Missing); smooth muscle: 96.1538% (minimum 99%, Missing); spinal cord: 96.7742% (minimum 99%, Missing); thyroid gland: 86.7052% (minimum 95%, Missing)",0,80,unavailable,13.6,2.9,2.3,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus,ENSG00000133640,LRRIQ1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.082948,-0.132011,-0.465524
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,199.5,28.6,15.1,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 2); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 2); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 2); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 2); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 2); amygdala: 16.7 nTPM (vital, limit 1); skin: 15.1 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 2); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000133816,MICAL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.7470% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.6678% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.4106% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.1269% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 18.2042% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 44.9848% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.2887% (minimum 99%, Baseline (adaptation disabled)); colon: 60.8219% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.8166% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.5835% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 48.1040% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.5740% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.3077% (minimum 99%, Baseline (adaptation disabled)); liver: 89.5161% (minimum 99%, Baseline (adaptation disabled)); lung: 64.2547% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.7975% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.7188% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.3124% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.5824% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.9787% (minimum 97%, Baseline (adaptation disabled)); retina: 91.5464% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.4839% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 66.5667% (minimum 99%, Baseline (adaptation disabled)); skin: 74.6218% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.0400% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 49.3882% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.0909% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.7975% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.1444% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.9255% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 83.6158% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.0609% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.3826% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,199.5,28.6,15.1,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 1); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 2); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 2); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 2); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 2); amygdala: 16.7 nTPM (vital, limit 1); skin: 15.1 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 2); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000133816,MICAL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.203782,-0.361781,-0.807958
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Missing); adrenal gland: 87.7470% (minimum 99%, Missing); amygdala: 72.6678% (minimum 99%, Missing); basal ganglia: 84.4106% (minimum 99%, Missing); bone marrow: 75.1269% (minimum 99%, Missing); cerebellum: 18.2042% (minimum 99%, Missing); cerebral cortex: 44.9848% (minimum 99%, Missing); choroid plexus: 76.2887% (minimum 99%, Missing); colon: 60.8219% (minimum 97%, Missing); duodenum: 76.8166% (minimum 99%, Missing); esophagus: 65.5835% (minimum 97%, Missing); heart muscle: 48.1040% (minimum 98%, Approved); hippocampal formation: 61.6667% (minimum 99%, Missing); hypothalamus: 87.5740% (minimum 99%, Missing); kidney: 92.3077% (minimum 99%, Missing); liver: 89.5161% (minimum 99%, Missing); lung: 64.2547% (minimum 99%, Missing); lymph node: 90.7975% (minimum 97%, Missing); midbrain: 92.5000% (minimum 99%, Missing); pancreas: 86.7188% (minimum 99%, Missing); parathyroid gland: 96.3124% (minimum 97%, Missing); pituitary gland: 97.5824% (minimum 99%, Missing); rectum: 62.9787% (minimum 97%, Missing); retina: 91.5464% (minimum 99%, Missing); salivary gland: 95.4839% (minimum 97%, Missing); skeletal muscle: 66.5667% (minimum 99%, Missing); skin: 74.6218% (minimum 95%, Missing); small intestine: 71.0400% (minimum 99%, Missing); smooth muscle: 49.3882% (minimum 99%, Missing); spinal cord: 84.0909% (minimum 99%, Missing); stomach: 80.1444% (minimum 97%, Missing); thymus: 91.9255% (minimum 95%, Missing); thyroid gland: 83.6158% (minimum 95%, Missing); tongue: 90.0609% (minimum 97%, Missing); urinary bladder: 71.3826% (minimum 97%, Missing)",0,2,partial,199.5,28.6,15.1,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 2); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 2); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 2); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 2); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 2); amygdala: 16.7 nTPM (vital, limit 1); skin: 15.1 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 2); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000133816,MICAL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.203782,-0.361781,-0.807958
True,compatible,,True,True,False,,0,3,partial,5.1,0.4,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000133863,TEX15,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.5207% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.1613% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.3333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.1613% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.8225% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.7213% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,5.1,0.4,0.2,"smooth muscle: 5.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000133863,TEX15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0333333,-0.00278689,-0.291775
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.5207% (minimum 99%, Missing); basal ganglia: 95.1613% (minimum 99%, Missing); hippocampal formation: 98.3333% (minimum 99%, Missing); hypothalamus: 98.3333% (minimum 99%, Missing); pituitary gland: 95.1613% (minimum 99%, Missing); smooth muscle: 69.8225% (minimum 95%, Enhanced)",0,3,partial,5.1,0.4,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000133863,TEX15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.251775
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.4,2.4,2.2,"pancreas: 10.4 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000133962,CATSPERB,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.9231% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.9231% (minimum 99%, Baseline (adaptation disabled)); colon: 62.5000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.9231% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 90.9091% (minimum 99%, Baseline (adaptation disabled)); lung: 62.5000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.6316% (minimum 97%, Baseline (adaptation disabled)); pancreas: 8.7719% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 76.9231% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 58.8235% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 29.4118% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 47.6190% (minimum 99%, Baseline (adaptation disabled)); skin: 31.2500% (minimum 95%, Baseline (adaptation disabled)); small intestine: 52.6316% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 41.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 76.9231% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 83.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.4,2.4,2.2,"pancreas: 10.4 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000133962,CATSPERB,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.6375,-0.675882,-0.902281
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 83.3333% (minimum 99%, Missing); bone marrow: 76.9231% (minimum 99%, Missing); cerebral cortex: 76.9231% (minimum 99%, Missing); colon: 62.5000% (minimum 97%, Missing); duodenum: 76.9231% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 71.4286% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 90.9091% (minimum 99%, Missing); lung: 62.5000% (minimum 99%, Missing); lymph node: 52.6316% (minimum 97%, Missing); pancreas: 8.7719% (minimum 99%, Missing); parathyroid gland: 76.9231% (minimum 97%, Missing); pituitary gland: 83.3333% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 58.8235% (minimum 99%, Missing); salivary gland: 29.4118% (minimum 97%, Missing); skeletal muscle: 47.6190% (minimum 99%, Missing); skin: 31.2500% (minimum 95%, Missing); small intestine: 52.6316% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spleen: 62.5000% (minimum 95%, Missing); stomach: 41.6667% (minimum 97%, Missing); thymus: 76.9231% (minimum 95%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); urinary bladder: 83.3333% (minimum 97%, Missing)",0,80,unavailable,10.4,2.4,2.2,"pancreas: 10.4 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000133962,CATSPERB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.6375,-0.675882,-0.902281
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000133980,VRTN,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 94.1176% (minimum 99%, Baseline (adaptation disabled)); colon: 94.1176% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled)); small intestine: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.1176% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.1176% (minimum 97%, Baseline (adaptation disabled)); tongue: 94.1176% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000133980,VRTN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,-0.00882353,-0.17,-0.101111
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 94.1176% (minimum 99%, Missing); colon: 94.1176% (minimum 97%, Missing); duodenum: 88.8889% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); small intestine: 88.8889% (minimum 99%, Missing); spleen: 94.1176% (minimum 95%, Missing); stomach: 94.1176% (minimum 97%, Missing); tongue: 94.1176% (minimum 97%, Missing)",0,80,unavailable,0.2,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000133980,VRTN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,-0.00882353,-0.17,-0.101111
True,compatible,,True,True,False,,0,1,partial,0.4,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000134007,ADAM20,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.0769% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.7273% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.0769% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.0769% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.0769% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.0769% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.0769% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0769% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0769% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.0769% (minimum 99%, Baseline (adaptation disabled)); retina: 92.7273% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.4,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000134007,ADAM20,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;da Silva 2017,0.0307692,0.0107692,-0.0627273
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.0769% (minimum 99%, Missing); cerebellum: 92.7273% (minimum 95%, Enhanced); hippocampal formation: 98.0769% (minimum 99%, Missing); hypothalamus: 98.0769% (minimum 99%, Missing); pituitary gland: 98.0769% (minimum 99%, Missing); retina: 92.7273% (minimum 99%, Missing)",0,1,partial,0.4,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000134007,ADAM20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;da Silva 2017,0.05,0.03,-0.0627273
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,20.1,31.3,30.1,"lymph node: 31.3 nTPM (protected, limit 2); thyroid gland: 30.1 nTPM (manageable, limit 5); esophagus: 28.7 nTPM (protected, limit 2); adipose tissue: 25.9 nTPM (manageable, limit 5); skin: 24.8 nTPM (manageable, limit 5); spleen: 20.6 nTPM (manageable, limit 5); urinary bladder: 20.2 nTPM (protected, limit 2); bone marrow: 20.1 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); salivary gland: 18.8 nTPM (protected, limit 2); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 2); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); parathyroid gland: 15.9 nTPM (protected, limit 2); rectum: 15.9 nTPM (protected, limit 2); lung: 15.9 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 2); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000134046,MBD2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1593% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.6875% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.3092% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.3550% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.1843% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.4615% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.8956% (minimum 99%, Baseline (adaptation disabled)); colon: 64.6934% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.3404% (minimum 99%, Baseline (adaptation disabled)); esophagus: 51.6020% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.5263% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.6875% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.3846% (minimum 99%, Baseline (adaptation disabled)); liver: 65.1064% (minimum 99%, Baseline (adaptation disabled)); lung: 65.8065% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.4346% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.3092% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.4211% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.8065% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.2727% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.8065% (minimum 97%, Baseline (adaptation disabled)); retina: 68.9189% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.9433% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 67.2527% (minimum 99%, Baseline (adaptation disabled)); skin: 55.2347% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.9584% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.6841% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.0781% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.7656% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.2308% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.0778% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.4119% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.5246% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.2362% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,20.1,31.3,30.1,"lymph node: 31.3 nTPM (protected, limit 2); thyroid gland: 30.1 nTPM (manageable, limit 5); esophagus: 28.7 nTPM (protected, limit 2); adipose tissue: 25.9 nTPM (manageable, limit 5); skin: 24.8 nTPM (manageable, limit 5); spleen: 20.6 nTPM (manageable, limit 5); urinary bladder: 20.2 nTPM (protected, limit 2); bone marrow: 20.1 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); salivary gland: 18.8 nTPM (protected, limit 2); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 2); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); parathyroid gland: 15.9 nTPM (protected, limit 2); rectum: 15.9 nTPM (protected, limit 2); lung: 15.9 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 2); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000134046,MBD2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.445881,-0.475654,-0.38645
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1593% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); amygdala: 79.6875% (minimum 99%, Missing); basal ganglia: 76.3092% (minimum 99%, Missing); bone marrow: 60.3550% (minimum 99%, Missing); cerebellum: 75.1843% (minimum 99%, Missing); cerebral cortex: 78.4615% (minimum 99%, Missing); choroid plexus: 79.8956% (minimum 99%, Missing); colon: 64.6934% (minimum 97%, Missing); duodenum: 72.3404% (minimum 99%, Missing); esophagus: 51.6020% (minimum 97%, Missing); heart muscle: 68.0000% (minimum 99%, Missing); hippocampal formation: 80.5263% (minimum 99%, Missing); hypothalamus: 79.6875% (minimum 99%, Missing); kidney: 65.3846% (minimum 99%, Missing); liver: 65.1064% (minimum 99%, Missing); lung: 65.8065% (minimum 99%, Missing); lymph node: 49.4346% (minimum 97%, Missing); midbrain: 76.3092% (minimum 99%, Missing); pancreas: 64.4211% (minimum 99%, Missing); parathyroid gland: 65.8065% (minimum 97%, Missing); pituitary gland: 77.2727% (minimum 99%, Missing); rectum: 65.8065% (minimum 97%, Missing); retina: 68.9189% (minimum 99%, Missing); salivary gland: 61.9433% (minimum 97%, Missing); skeletal muscle: 67.2527% (minimum 99%, Missing); skin: 55.2347% (minimum 95%, Missing); small intestine: 66.9584% (minimum 99%, Missing); smooth muscle: 72.6841% (minimum 99%, Missing); spinal cord: 77.0781% (minimum 99%, Missing); spleen: 59.7656% (minimum 95%, Missing); stomach: 69.2308% (minimum 97%, Missing); thymus: 61.0778% (minimum 95%, Missing); thyroid gland: 50.4119% (minimum 95%, Missing); tongue: 65.5246% (minimum 97%, Missing); urinary bladder: 60.2362% (minimum 97%, Missing)",0,4,partial,20.1,31.3,30.1,"lymph node: 31.3 nTPM (protected, limit 2); thyroid gland: 30.1 nTPM (manageable, limit 5); esophagus: 28.7 nTPM (protected, limit 2); adipose tissue: 25.9 nTPM (manageable, limit 5); skin: 24.8 nTPM (manageable, limit 5); spleen: 20.6 nTPM (manageable, limit 5); urinary bladder: 20.2 nTPM (protected, limit 2); bone marrow: 20.1 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); salivary gland: 18.8 nTPM (protected, limit 2); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 2); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); parathyroid gland: 15.9 nTPM (protected, limit 2); rectum: 15.9 nTPM (protected, limit 2); lung: 15.9 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 2); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000134046,MBD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.445881,-0.475654,-0.38645
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,13,partial,30.3,20.9,15.4,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 2); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 2); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 2); thyroid gland: 15.4 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); salivary gland: 14.6 nTPM (protected, limit 2); cerebellum: 14.3 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); urinary bladder: 13.4 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); pancreas: 13.2 nTPM (vital, limit 1); rectum: 12.6 nTPM (protected, limit 2); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 2); lymph node: 11.1 nTPM (protected, limit 2); spleen: 10.8 nTPM (manageable, limit 5); thymus: 10.8 nTPM (manageable, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 3); cerebral cortex: 8.3 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),97,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000134049,IER3IP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.9294% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 45.0658% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.0187% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.3192% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.9286% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.9286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.2727% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 47.5694% (minimum 99%, Baseline (adaptation disabled)); colon: 50.1832% (minimum 97%, Baseline (adaptation disabled)); duodenum: 45.3642% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.9370% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 45.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.6226% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 59.0517% (minimum 99%, Baseline (adaptation disabled)); kidney: 31.1364% (minimum 99%, Baseline (adaptation disabled)); liver: 42.0245% (minimum 99%, Baseline (adaptation disabled)); lung: 53.5156% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.2419% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.0187% (minimum 99%, Baseline (adaptation disabled)); pancreas: 50.9294% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 42.5466% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 47.5694% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.0913% (minimum 97%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 48.4099% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 31.3501% (minimum 99%, Baseline (adaptation disabled)); skin: 50.5535% (minimum 95%, Baseline (adaptation disabled)); small intestine: 47.2414% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.8253% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.9289% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.9184% (minimum 95%, Baseline (adaptation disabled)); stomach: 46.9178% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.9184% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 47.0790% (minimum 95%, Baseline (adaptation disabled)); tongue: 39.5954% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.5535% (minimum 97%, Baseline (adaptation disabled))",0,13,partial,30.3,20.9,15.4,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 2); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 2); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 2); thyroid gland: 15.4 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); salivary gland: 14.6 nTPM (protected, limit 2); cerebellum: 14.3 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); urinary bladder: 13.4 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); pancreas: 13.2 nTPM (vital, limit 1); rectum: 12.6 nTPM (protected, limit 2); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 2); lymph node: 11.1 nTPM (protected, limit 2); spleen: 10.8 nTPM (manageable, limit 5); thymus: 10.8 nTPM (manageable, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),97,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000134049,IER3IP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.47921,-0.574046,-0.678636
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.9294% (minimum 95%, Missing); adrenal gland: 45.0658% (minimum 99%, Missing); amygdala: 64.0187% (minimum 99%, Missing); basal ganglia: 64.3192% (minimum 99%, Missing); bone marrow: 48.9286% (minimum 99%, Missing); cerebellum: 48.9286% (minimum 99%, Missing); cerebral cortex: 62.2727% (minimum 99%, Missing); choroid plexus: 47.5694% (minimum 99%, Missing); colon: 50.1832% (minimum 97%, Missing); duodenum: 45.3642% (minimum 99%, Missing); esophagus: 53.9370% (minimum 97%, Missing); heart muscle: 45.6667% (minimum 99%, Missing); hippocampal formation: 64.6226% (minimum 99%, Missing); hypothalamus: 59.0517% (minimum 99%, Missing); kidney: 31.1364% (minimum 99%, Missing); liver: 42.0245% (minimum 99%, Missing); lung: 53.5156% (minimum 99%, Missing); lymph node: 55.2419% (minimum 97%, Missing); midbrain: 64.0187% (minimum 99%, Missing); pancreas: 50.9294% (minimum 99%, Missing); parathyroid gland: 42.5466% (minimum 97%, Missing); pituitary gland: 47.5694% (minimum 99%, Missing); rectum: 52.0913% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 48.4099% (minimum 97%, Missing); skeletal muscle: 31.3501% (minimum 99%, Missing); skin: 50.5535% (minimum 95%, Missing); small intestine: 47.2414% (minimum 99%, Missing); smooth muscle: 59.8253% (minimum 97%, Supported); spinal cord: 64.9289% (minimum 99%, Missing); spleen: 55.9184% (minimum 95%, Missing); stomach: 46.9178% (minimum 97%, Missing); thymus: 55.9184% (minimum 95%, Missing); thyroid gland: 47.0790% (minimum 95%, Missing); tongue: 39.5954% (minimum 97%, Missing); urinary bladder: 50.5535% (minimum 97%, Missing)",0,13,partial,30.3,20.9,15.4,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 2); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 2); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 2); thyroid gland: 15.4 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); salivary gland: 14.6 nTPM (protected, limit 2); cerebellum: 14.3 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); skin: 13.4 nTPM (manageable, limit 5); urinary bladder: 13.4 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); pancreas: 13.2 nTPM (vital, limit 1); rectum: 12.6 nTPM (protected, limit 2); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 2); lymph node: 11.1 nTPM (protected, limit 2); spleen: 10.8 nTPM (manageable, limit 5); thymus: 10.8 nTPM (manageable, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 3); cerebral cortex: 8.3 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),97,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000134049,IER3IP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.47921,-0.574046,-0.678636
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,13.8,9.2,10.5,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (manageable, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); esophagus: 9.2 nTPM (protected, limit 4); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 2); adipose tissue: 8.3 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 2); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 2); thymus: 6.8 nTPM (manageable, limit 5); tongue: 6.6 nTPM (protected, limit 2); salivary gland: 6.5 nTPM (protected, limit 2); colon: 6.5 nTPM (protected, limit 2); stomach: 6.5 nTPM (protected, limit 2); small intestine: 6.4 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 2); spinal cord: 6.1 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 2); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 4); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000134146,DPH6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.3158% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 59.7765% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.2973% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.4596% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.3521% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.8750% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.5897% (minimum 99%, Baseline (adaptation disabled)); colon: 62.2093% (minimum 97%, Baseline (adaptation disabled)); duodenum: 63.6905% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.7688% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.1951% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.7931% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.2877% (minimum 99%, Baseline (adaptation disabled)); kidney: 51.4423% (minimum 99%, Baseline (adaptation disabled)); liver: 57.8378% (minimum 99%, Baseline (adaptation disabled)); lung: 67.2956% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.7215% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.5897% (minimum 99%, Baseline (adaptation disabled)); pancreas: 43.6735% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 56.0209% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 65.2439% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.1429% (minimum 97%, Baseline (adaptation disabled)); retina: 55.4404% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.2093% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.7109% (minimum 99%, Baseline (adaptation disabled)); skin: 53.2338% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.5731% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.3136% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.6905% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.3136% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.2093% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.1429% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.4717% (minimum 95%, Baseline (adaptation disabled)); tongue: 61.8497% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.8378% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,13.8,9.2,10.5,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (manageable, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.4 nTPM (manageable, limit 5); esophagus: 9.2 nTPM (protected, limit 2); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 2); adipose tissue: 8.3 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 2); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 2); thymus: 6.8 nTPM (manageable, limit 5); tongue: 6.6 nTPM (protected, limit 2); salivary gland: 6.5 nTPM (protected, limit 2); colon: 6.5 nTPM (protected, limit 2); stomach: 6.5 nTPM (protected, limit 2); small intestine: 6.4 nTPM (vital, limit 1); spleen: 6.2 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000134146,DPH6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.445283,-0.432312,-0.553265
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.3158% (minimum 95%, Missing); adrenal gland: 59.7765% (minimum 99%, Missing); amygdala: 72.2973% (minimum 99%, Missing); basal ganglia: 71.3333% (minimum 99%, Missing); bone marrow: 66.4596% (minimum 98%, Approved); cerebellum: 75.3521% (minimum 98%, Approved); cerebral cortex: 66.8750% (minimum 99%, Missing); choroid plexus: 68.5897% (minimum 99%, Missing); colon: 62.2093% (minimum 97%, Missing); duodenum: 63.6905% (minimum 99%, Missing); esophagus: 53.7688% (minimum 95%, Approved); heart muscle: 52.1951% (minimum 99%, Missing); hippocampal formation: 73.7931% (minimum 99%, Missing); hypothalamus: 73.2877% (minimum 99%, Missing); kidney: 51.4423% (minimum 99%, Missing); liver: 57.8378% (minimum 99%, Missing); lung: 67.2956% (minimum 99%, Missing); lymph node: 67.7215% (minimum 95%, Approved); midbrain: 68.5897% (minimum 99%, Missing); pancreas: 43.6735% (minimum 99%, Missing); parathyroid gland: 56.0209% (minimum 97%, Missing); pituitary gland: 65.2439% (minimum 99%, Missing); rectum: 61.1429% (minimum 97%, Missing); retina: 55.4404% (minimum 99%, Missing); salivary gland: 62.2093% (minimum 97%, Missing); skeletal muscle: 50.7109% (minimum 99%, Missing); skin: 53.2338% (minimum 90%, Approved); small intestine: 62.5731% (minimum 99%, Missing); smooth muscle: 63.3136% (minimum 98%, Approved); spinal cord: 63.6905% (minimum 99%, Missing); spleen: 63.3136% (minimum 90%, Approved); stomach: 62.2093% (minimum 97%, Missing); thymus: 61.1429% (minimum 95%, Missing); thyroid gland: 50.4717% (minimum 95%, Missing); tongue: 61.8497% (minimum 97%, Missing); urinary bladder: 57.8378% (minimum 97%, Missing)",0,2,partial,13.8,9.2,10.5,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (manageable, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); esophagus: 9.2 nTPM (protected, limit 4); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 2); adipose tissue: 8.3 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 2); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 2); thymus: 6.8 nTPM (manageable, limit 5); tongue: 6.6 nTPM (protected, limit 2); salivary gland: 6.5 nTPM (protected, limit 2); colon: 6.5 nTPM (protected, limit 2); stomach: 6.5 nTPM (protected, limit 2); small intestine: 6.4 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 2); spinal cord: 6.1 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 2); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 4); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000134146,DPH6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.445283,-0.412312,-0.553265
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,17,0.1,4.7,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),62,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000134160,TRPM1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.3043% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.3043% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.4545% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.5000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.4545% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.4545% (minimum 99%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 10.9948% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.4545% (minimum 97%, Baseline (adaptation disabled)); skin: 30.8824% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 72.4138% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,17,0.1,4.7,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),62,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000134160,TRPM1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.641176,-0.0154545,-0.880052
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 91.3043% (minimum 99%, Missing); choroid plexus: 95.4545% (minimum 99%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); midbrain: 75.0000% (minimum 99%, Missing); retina: 10.9948% (minimum 99%, Missing); skin: 30.8824% (minimum 60%, Enhanced); spinal cord: 72.4138% (minimum 99%, Missing)",0,2,partial,17,0.1,4.7,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),62,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000134160,TRPM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.291176,0.03,-0.880052
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,81,49.2,47.7,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 2); skin: 47.7 nTPM (manageable, limit 5); colon: 39.9 nTPM (protected, limit 2); esophagus: 33.8 nTPM (protected, limit 2); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 2); spleen: 10.9 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 2); thyroid gland: 9.6 nTPM (manageable, limit 5); duodenum: 9 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); retina: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); salivary gland: 7.1 nTPM (protected, limit 2); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000134215,VAV3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.7127% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.1289% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.6772% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.0510% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.4799% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.4791% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.7853% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.2080% (minimum 99%, Baseline (adaptation disabled)); colon: 45.4172% (minimum 97%, Baseline (adaptation disabled)); duodenum: 78.6730% (minimum 99%, Baseline (adaptation disabled)); esophagus: 49.5522% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.6772% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.0760% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.1289% (minimum 99%, Baseline (adaptation disabled)); kidney: 29.0718% (minimum 99%, Baseline (adaptation disabled)); liver: 93.5211% (minimum 99%, Baseline (adaptation disabled)); lung: 89.4879% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.6744% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.9729% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.4000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.6772% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.2319% (minimum 99%, Baseline (adaptation disabled)); rectum: 40.2913% (minimum 97%, Baseline (adaptation disabled)); retina: 82.3821% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.3821% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.3607% (minimum 99%, Baseline (adaptation disabled)); skin: 41.0383% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.1667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.4632% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2249% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.2834% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.3821% (minimum 97%, Baseline (adaptation disabled)); thymus: 79.4258% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 77.5701% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.5116% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.9670% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,81,49.2,47.7,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 2); skin: 47.7 nTPM (manageable, limit 5); colon: 39.9 nTPM (protected, limit 2); esophagus: 33.8 nTPM (protected, limit 2); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 2); spleen: 10.9 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 2); thyroid gland: 9.6 nTPM (manageable, limit 5); duodenum: 9 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); retina: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); salivary gland: 7.1 nTPM (protected, limit 2); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000134215,VAV3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.539617,-0.567087,-0.699282
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.7127% (minimum 95%, Missing); adrenal gland: 95.1289% (minimum 99%, Missing); amygdala: 95.6772% (minimum 99%, Missing); basal ganglia: 94.0510% (minimum 99%, Missing); bone marrow: 63.4799% (minimum 99%, Missing); cerebellum: 92.4791% (minimum 99%, Missing); cerebral cortex: 93.7853% (minimum 99%, Missing); choroid plexus: 83.2080% (minimum 99%, Missing); colon: 45.4172% (minimum 97%, Missing); duodenum: 78.6730% (minimum 99%, Missing); esophagus: 49.5522% (minimum 97%, Uncertain); heart muscle: 95.6772% (minimum 99%, Uncertain); hippocampal formation: 97.0760% (minimum 99%, Missing); hypothalamus: 95.1289% (minimum 99%, Missing); kidney: 29.0718% (minimum 99%, Missing); liver: 93.5211% (minimum 99%, Missing); lung: 89.4879% (minimum 99%, Missing); lymph node: 76.6744% (minimum 97%, Missing); midbrain: 89.9729% (minimum 99%, Missing); pancreas: 66.4000% (minimum 99%, Missing); parathyroid gland: 95.6772% (minimum 97%, Missing); pituitary gland: 96.2319% (minimum 99%, Missing); rectum: 40.2913% (minimum 97%, Missing); retina: 82.3821% (minimum 99%, Missing); salivary gland: 82.3821% (minimum 97%, Missing); skeletal muscle: 97.3607% (minimum 99%, Uncertain); skin: 41.0383% (minimum 95%, Missing); small intestine: 69.1667% (minimum 99%, Missing); smooth muscle: 90.4632% (minimum 99%, Uncertain); spinal cord: 98.2249% (minimum 99%, Missing); spleen: 75.2834% (minimum 95%, Missing); stomach: 82.3821% (minimum 97%, Missing); thymus: 79.4258% (minimum 95%, Missing); thyroid gland: 77.5701% (minimum 95%, Missing); tongue: 96.5116% (minimum 97%, Missing); urinary bladder: 72.9670% (minimum 97%, Missing)",0,7,partial,81,49.2,47.7,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 2); skin: 47.7 nTPM (manageable, limit 5); colon: 39.9 nTPM (protected, limit 2); esophagus: 33.8 nTPM (protected, limit 2); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 2); spleen: 10.9 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 2); thyroid gland: 9.6 nTPM (manageable, limit 5); duodenum: 9 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); retina: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); salivary gland: 7.1 nTPM (protected, limit 2); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000134215,VAV3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.539617,-0.567087,-0.699282
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000134249,ADAM30,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000134249,ADAM30,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000134249,ADAM30,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,6.5,2.3,3.1,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000134256,CD101,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 46.1538% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 11.3208% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.7143% (minimum 99%, Baseline (adaptation disabled)); colon: 25.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 14.6341% (minimum 99%, Baseline (adaptation disabled)); esophagus: 40.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 50.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 8.4507% (minimum 99%, Baseline (adaptation disabled)); lymph node: 24.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.7143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 42.8571% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); rectum: 20.6897% (minimum 97%, Baseline (adaptation disabled)); retina: 85.7143% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 28.5714% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); skin: 40.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 8.9552% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 31.5789% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 16.2162% (minimum 95%, Baseline (adaptation disabled)); stomach: 30.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 33.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 33.3333% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,6.5,2.3,3.1,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000134256,CD101,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.787838,-0.763103,-0.905493
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 90%, Approved); adrenal gland: 46.1538% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 11.3208% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 85.7143% (minimum 99%, Missing); colon: 25.0000% (minimum 97%, Missing); duodenum: 14.6341% (minimum 99%, Missing); esophagus: 40.0000% (minimum 97%, Missing); heart muscle: 60.0000% (minimum 99%, Missing); hippocampal formation: 85.7143% (minimum 99%, Missing); hypothalamus: 85.7143% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 50.0000% (minimum 99%, Missing); lung: 8.4507% (minimum 99%, Missing); lymph node: 24.0000% (minimum 97%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 42.8571% (minimum 99%, Missing); pituitary gland: 85.7143% (minimum 99%, Missing); rectum: 20.6897% (minimum 97%, Missing); retina: 85.7143% (minimum 99%, Missing); salivary gland: 28.5714% (minimum 97%, Missing); skeletal muscle: 85.7143% (minimum 99%, Missing); skin: 40.0000% (minimum 95%, Missing); small intestine: 8.9552% (minimum 99%, Missing); smooth muscle: 31.5789% (minimum 99%, Missing); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 16.2162% (minimum 90%, Approved); stomach: 30.0000% (minimum 97%, Missing); thymus: 33.3333% (minimum 95%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); urinary bladder: 33.3333% (minimum 95%, Approved)",0,2,partial,6.5,2.3,3.1,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000134256,CD101,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.737838,-0.763103,-0.905493
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,72.4,0.4,0.2,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 2); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 2); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),63,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000134376,CRB1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.5517% (minimum 99%, Baseline (adaptation disabled)); amygdala: 19.4444% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 19.1781% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 87.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 22.7642% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 19.1781% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 96.5517% (minimum 97%, Baseline (adaptation disabled)); esophagus: 96.5517% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.5517% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 22.4000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 30.1075% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.5517% (minimum 99%, Baseline (adaptation disabled)); lung: 96.5517% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.5517% (minimum 97%, Baseline (adaptation disabled)); midbrain: 38.8889% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.3226% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 57.1429% (minimum 99%, Baseline (adaptation disabled)); retina: 3.7234% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 82.3529% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 43.7500% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.3333% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.5000% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,72.4,0.4,0.2,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),63,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000134376,CRB1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0166667,-0.095,-0.952766
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.5517% (minimum 98%, Approved); amygdala: 19.4444% (minimum 99%, Missing); basal ganglia: 19.1781% (minimum 99%, Missing); bone marrow: 87.5000% (minimum 98%, Approved); cerebellum: 22.7642% (minimum 98%, Approved); cerebral cortex: 19.1781% (minimum 98%, Approved); choroid plexus: 80.0000% (minimum 99%, Missing); heart muscle: 96.5517% (minimum 98%, Approved); hippocampal formation: 22.4000% (minimum 99%, Missing); hypothalamus: 30.1075% (minimum 99%, Missing); kidney: 96.5517% (minimum 98%, Approved); lung: 96.5517% (minimum 98%, Approved); midbrain: 38.8889% (minimum 99%, Missing); pancreas: 90.3226% (minimum 98%, Approved); pituitary gland: 57.1429% (minimum 99%, Missing); retina: 3.7234% (minimum 99%, Missing); skeletal muscle: 82.3529% (minimum 98%, Approved); spinal cord: 43.7500% (minimum 99%, Missing); stomach: 93.3333% (minimum 95%, Approved); tongue: 87.5000% (minimum 97%, Missing)",0,0,routine_complete,72.4,0.4,0.2,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 2); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 2); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),63,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000134376,CRB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0333333,-0.095,-0.952766
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,1,partial,162,0,0,"liver: 162 nTPM (vital, limit 3)",,55,not_established,not_triggered,,,ENSG00000134389,CFHR5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,1,partial,162,0,0,"liver: 162 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,ENSG00000134389,CFHR5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,1,partial,162,0,0,"liver: 162 nTPM (vital, limit 3)",,55,not_established,not_triggered,,,ENSG00000134389,CFHR5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.8,2.3,2.1,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000134490,TMEM241,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.3810% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.5714% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.5714% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.7500% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 45.8333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.6522% (minimum 99%, Baseline (adaptation disabled)); colon: 57.8947% (minimum 97%, Baseline (adaptation disabled)); duodenum: 59.4595% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.8947% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.4595% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.5714% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.8621% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.7500% (minimum 99%, Baseline (adaptation disabled)); liver: 57.8947% (minimum 99%, Baseline (adaptation disabled)); lung: 61.1111% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.1111% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.4815% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.7059% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 48.8889% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.7500% (minimum 99%, Baseline (adaptation disabled)); rectum: 50.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 88.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.7500% (minimum 99%, Baseline (adaptation disabled)); skin: 73.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 44.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.5714% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.1111% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.1111% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.7500% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 51.1628% (minimum 95%, Baseline (adaptation disabled)); tongue: 73.3333% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.4595% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.8,2.3,2.1,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000134490,TMEM241,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.438372,-0.481111,-0.55
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.3810% (minimum 95%, Missing); adrenal gland: 78.5714% (minimum 99%, Missing); amygdala: 78.5714% (minimum 99%, Missing); basal ganglia: 68.7500% (minimum 99%, Missing); bone marrow: 66.6667% (minimum 99%, Missing); cerebellum: 91.6667% (minimum 99%, Missing); cerebral cortex: 45.8333% (minimum 99%, Missing); choroid plexus: 95.6522% (minimum 99%, Missing); colon: 57.8947% (minimum 97%, Missing); duodenum: 59.4595% (minimum 99%, Missing); esophagus: 57.8947% (minimum 97%, Missing); heart muscle: 59.4595% (minimum 99%, Missing); hippocampal formation: 78.5714% (minimum 99%, Missing); hypothalamus: 75.8621% (minimum 99%, Missing); kidney: 68.7500% (minimum 99%, Missing); liver: 57.8947% (minimum 99%, Missing); lung: 61.1111% (minimum 99%, Missing); lymph node: 61.1111% (minimum 97%, Missing); midbrain: 81.4815% (minimum 99%, Missing); pancreas: 64.7059% (minimum 99%, Missing); parathyroid gland: 48.8889% (minimum 97%, Missing); pituitary gland: 68.7500% (minimum 99%, Missing); rectum: 50.0000% (minimum 97%, Missing); retina: 88.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 68.7500% (minimum 99%, Missing); skin: 73.3333% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); smooth muscle: 44.0000% (minimum 99%, Missing); spinal cord: 78.5714% (minimum 99%, Missing); spleen: 61.1111% (minimum 95%, Missing); stomach: 61.1111% (minimum 97%, Missing); thymus: 68.7500% (minimum 95%, Missing); thyroid gland: 51.1628% (minimum 95%, Missing); tongue: 73.3333% (minimum 97%, Missing); urinary bladder: 59.4595% (minimum 97%, Missing)",0,80,unavailable,2.8,2.3,2.1,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000134490,TMEM241,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.438372,-0.481111,-0.55
True,compatible,,True,True,False,,0,3,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000134588,USP26,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 80.0000% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000134588,USP26,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.15,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 80.0000% (minimum 90%, Approved)",0,3,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000134588,USP26,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.1,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.1,0,0.1,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000134595,SOX3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8889% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.7619% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.1776% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.7391% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.5769% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.2549% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.1667% (minimum 99%, Baseline (adaptation disabled)); midbrain: 87.2549% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 83.1776% (minimum 99%, Baseline (adaptation disabled)); retina: 97.8022% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.8022% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.1,0,0.1,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000134595,SOX3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0388889,0.03,-0.248333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8889% (minimum 99%, Missing); amygdala: 84.7619% (minimum 99%, Missing); basal ganglia: 83.1776% (minimum 99%, Missing); cerebellum: 96.7391% (minimum 99%, Missing); cerebral cortex: 85.5769% (minimum 99%, Missing); hippocampal formation: 87.2549% (minimum 99%, Missing); hypothalamus: 74.1667% (minimum 99%, Missing); midbrain: 87.2549% (minimum 99%, Missing); pituitary gland: 83.1776% (minimum 99%, Missing); retina: 97.8022% (minimum 99%, Missing); skeletal muscle: 97.8022% (minimum 99%, Missing); spinal cord: 89.0000% (minimum 99%, Missing)",0,80,unavailable,3.1,0,0.1,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000134595,SOX3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0388889,0.03,-0.248333
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,0.3,0,0,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); skin 1 / fibroblasts: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; tonsil,ENSG00000134640,MTNR1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 76.9231% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.9091% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.3,0,0,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); skin 1 / fibroblasts: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; tonsil,ENSG00000134640,MTNR1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,0.05,0.03,-0.220769
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 76.9231% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 99%, Missing)",0,3,partial,0.3,0,0,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); skin 1 / fibroblasts: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; tonsil,ENSG00000134640,MTNR1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,0.05,0.03,-0.220769
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,12,partial,33.1,19,37.8,"thymus: 37.8 nTPM (manageable, limit 5); bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 2); rectum: 10.9 nTPM (protected, limit 2); colon: 9.1 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),90,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000134690,CDCA8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.6332% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.0526% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 39.8182% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.7679% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.4758% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.2063% (minimum 99%, Baseline (adaptation disabled)); colon: 70.6452% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.8738% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.4758% (minimum 99%, Baseline (adaptation disabled)); liver: 94.3966% (minimum 99%, Baseline (adaptation disabled)); lung: 93.9914% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.5452% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.9027% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.4758% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.7683% (minimum 97%, Baseline (adaptation disabled)); retina: 92.4051% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.4051% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.6486% (minimum 99%, Baseline (adaptation disabled)); skin: 77.9359% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.5172% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.0244% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.4758% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.0225% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.3308% (minimum 97%, Baseline (adaptation disabled)); thymus: 36.6834% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.0168% (minimum 97%, Baseline (adaptation disabled))",0,12,partial,33.1,19,37.8,"thymus: 37.8 nTPM (manageable, limit 5); bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 2); rectum: 10.9 nTPM (protected, limit 2); colon: 9.1 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),90,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000134690,CDCA8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.583166,-0.434548,-0.591818
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.6332% (minimum 99%, Missing); amygdala: 97.3333% (minimum 99%, Missing); basal ganglia: 96.0526% (minimum 99%, Missing); bone marrow: 39.8182% (minimum 99%, Missing); cerebellum: 97.7679% (minimum 99%, Missing); cerebral cortex: 96.4758% (minimum 99%, Missing); choroid plexus: 98.2063% (minimum 99%, Missing); colon: 70.6452% (minimum 97%, Missing); duodenum: 73.0000% (minimum 99%, Missing); esophagus: 70.8738% (minimum 97%, Missing); hippocampal formation: 97.3333% (minimum 99%, Missing); hypothalamus: 97.3333% (minimum 99%, Missing); kidney: 96.4758% (minimum 99%, Missing); liver: 94.3966% (minimum 99%, Missing); lung: 93.9914% (minimum 95%, Enhanced); lymph node: 53.5452% (minimum 97%, Missing); midbrain: 96.9027% (minimum 99%, Missing); pancreas: 96.4758% (minimum 99%, Missing); pituitary gland: 97.3333% (minimum 99%, Missing); rectum: 66.7683% (minimum 97%, Missing); retina: 92.4051% (minimum 99%, Missing); skin: 77.9359% (minimum 95%, Missing); small intestine: 75.5172% (minimum 99%, Missing); smooth muscle: 89.0244% (minimum 95%, Enhanced); spinal cord: 96.4758% (minimum 99%, Missing); stomach: 82.3308% (minimum 97%, Missing); thymus: 36.6834% (minimum 95%, Missing); urinary bladder: 92.0168% (minimum 97%, Missing)",0,12,partial,33.1,19,37.8,"thymus: 37.8 nTPM (manageable, limit 5); bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 2); rectum: 10.9 nTPM (protected, limit 2); colon: 9.1 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); retina: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),90,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000134690,CDCA8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.583166,-0.434548,-0.591818
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,94.8,23.6,28.1,"bone marrow: 94.8 nTPM (vital, limit 1); thymus: 28.1 nTPM (manageable, limit 5); lymph node: 23.6 nTPM (protected, limit 2); colon: 22.7 nTPM (protected, limit 2); liver: 21 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); rectum: 19.6 nTPM (protected, limit 2); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 2); stomach: 13.8 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 2); thyroid gland: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); skin: 8.6 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 2); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000134758,RNF138,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.7833% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.2323% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.3857% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.9264% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.0285% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.2476% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.2099% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.5058% (minimum 99%, Baseline (adaptation disabled)); colon: 83.6337% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.7458% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.9571% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.3164% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.0795% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.3089% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.5778% (minimum 99%, Baseline (adaptation disabled)); liver: 84.6715% (minimum 99%, Baseline (adaptation disabled)); lung: 89.9922% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.0946% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.7753% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.0121% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.4826% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.0795% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.5457% (minimum 97%, Baseline (adaptation disabled)); retina: 93.0233% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.3567% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.5395% (minimum 99%, Baseline (adaptation disabled)); skin: 93.0979% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.3494% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.1233% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.6996% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.6715% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.3683% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.4997% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.9804% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.6166% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.0621% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,94.8,23.6,28.1,"bone marrow: 94.8 nTPM (vital, limit 1); thymus: 28.1 nTPM (manageable, limit 5); lymph node: 23.6 nTPM (protected, limit 2); colon: 22.7 nTPM (protected, limit 2); liver: 21 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); rectum: 19.6 nTPM (protected, limit 2); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 2); stomach: 13.8 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 2); thyroid gland: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); skin: 8.6 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 2); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000134758,RNF138,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.145003,-0.139054,-0.439715
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.7833% (minimum 95%, Missing); adrenal gland: 94.2323% (minimum 99%, Missing); amygdala: 94.3857% (minimum 99%, Missing); basal ganglia: 94.9264% (minimum 99%, Missing); bone marrow: 55.0285% (minimum 99%, Missing); cerebellum: 93.2476% (minimum 99%, Missing); cerebral cortex: 92.2099% (minimum 99%, Missing); choroid plexus: 96.5058% (minimum 99%, Missing); colon: 83.6337% (minimum 97%, Missing); duodenum: 87.7458% (minimum 99%, Missing); esophagus: 88.9571% (minimum 97%, Missing); heart muscle: 95.3164% (minimum 99%, Missing); hippocampal formation: 94.0795% (minimum 99%, Missing); hypothalamus: 94.3089% (minimum 99%, Missing); kidney: 92.5778% (minimum 99%, Missing); liver: 84.6715% (minimum 99%, Missing); lung: 89.9922% (minimum 99%, Missing); lymph node: 83.0946% (minimum 97%, Missing); midbrain: 93.7753% (minimum 99%, Missing); pancreas: 88.0121% (minimum 99%, Missing); parathyroid gland: 91.4826% (minimum 97%, Missing); pituitary gland: 94.0795% (minimum 99%, Missing); rectum: 85.5457% (minimum 97%, Missing); retina: 93.0233% (minimum 99%, Missing); salivary gland: 92.3567% (minimum 97%, Missing); skeletal muscle: 94.5395% (minimum 99%, Missing); skin: 93.0979% (minimum 95%, Missing); small intestine: 87.3494% (minimum 99%, Missing); smooth muscle: 91.1233% (minimum 99%, Missing); spinal cord: 91.6996% (minimum 99%, Missing); spleen: 84.6715% (minimum 95%, Missing); stomach: 89.3683% (minimum 97%, Missing); thymus: 80.4997% (minimum 95%, Missing); thyroid gland: 90.9804% (minimum 95%, Missing); tongue: 94.6166% (minimum 97%, Missing); urinary bladder: 90.0621% (minimum 97%, Missing)",0,80,unavailable,94.8,23.6,28.1,"bone marrow: 94.8 nTPM (vital, limit 1); thymus: 28.1 nTPM (manageable, limit 5); lymph node: 23.6 nTPM (protected, limit 2); colon: 22.7 nTPM (protected, limit 2); liver: 21 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); rectum: 19.6 nTPM (protected, limit 2); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 2); stomach: 13.8 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 2); thyroid gland: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); skin: 8.6 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 2); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000134758,RNF138,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.145003,-0.139054,-0.439715
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,2.4,0.4,0.1,"basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ENSG00000134940,ACRV1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8666% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.9275% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6087% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9529% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9529% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,2.4,0.4,0.1,"basal ganglia: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ENSG00000134940,ACRV1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0491189,0.0264851,-0.0107254
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8666% (minimum 99%, Missing); basal ganglia: 97.9275% (minimum 99%, Missing); hippocampal formation: 98.9529% (minimum 99%, Missing); hypothalamus: 98.9529% (minimum 99%, Missing)",0,3,partial,2.4,0.4,0.1,"basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,ENSG00000134940,ACRV1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0107254
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,77.9,51.8,77.4,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (manageable, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 2); smooth muscle: 43.4 nTPM (vital, limit 3); salivary gland: 42.2 nTPM (protected, limit 2); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 2); colon: 40.7 nTPM (protected, limit 2); stomach: 40.4 nTPM (protected, limit 2); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 2); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (manageable, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 2); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); pituitary gland: 27.2 nTPM (vital, limit 1); spleen: 25.3 nTPM (manageable, limit 5); tongue: 23.8 nTPM (protected, limit 2); lymph node: 22.9 nTPM (protected, limit 2); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); thymus: 19 nTPM (manageable, limit 5); retina: 18.6 nTPM (vital, limit 1); skin: 18.4 nTPM (manageable, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 1 / vascular mural cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000134970,TMED7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.9599% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.1919% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.4887% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.5363% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.5686% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.2720% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.4316% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.4115% (minimum 99%, Baseline (adaptation disabled)); colon: 62.7289% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.6130% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.5686% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.9910% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.6906% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.7077% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.7053% (minimum 99%, Baseline (adaptation disabled)); liver: 46.7896% (minimum 99%, Baseline (adaptation disabled)); lung: 69.8267% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.9453% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.3575% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6991% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 56.9410% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.5778% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.6143% (minimum 97%, Baseline (adaptation disabled)); retina: 78.6452% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.8790% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.3657% (minimum 99%, Baseline (adaptation disabled)); skin: 78.8262% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.7448% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.2154% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.3760% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.0277% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.9017% (minimum 97%, Baseline (adaptation disabled)); thymus: 78.2857% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 46.9500% (minimum 95%, Baseline (adaptation disabled)); tongue: 74.2145% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.3626% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,77.9,51.8,77.4,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (manageable, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 2); smooth muscle: 43.4 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 2); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 2); colon: 40.7 nTPM (protected, limit 2); stomach: 40.4 nTPM (protected, limit 2); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 2); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (manageable, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 2); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); pituitary gland: 27.2 nTPM (vital, limit 1); spleen: 25.3 nTPM (manageable, limit 5); tongue: 23.8 nTPM (protected, limit 2); lymph node: 22.9 nTPM (protected, limit 2); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); thymus: 19 nTPM (manageable, limit 5); retina: 18.6 nTPM (vital, limit 1); skin: 18.4 nTPM (manageable, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 1 / vascular mural cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000134970,TMED7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4805,-0.40059,-0.522104
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.9599% (minimum 95%, Missing); adrenal gland: 63.1919% (minimum 99%, Missing); amygdala: 77.4887% (minimum 99%, Missing); basal ganglia: 76.5363% (minimum 99%, Missing); bone marrow: 68.5686% (minimum 99%, Missing); cerebellum: 86.2720% (minimum 99%, Missing); cerebral cortex: 68.4316% (minimum 99%, Missing); choroid plexus: 85.4115% (minimum 99%, Missing); colon: 62.7289% (minimum 97%, Missing); duodenum: 65.6130% (minimum 99%, Missing); esophagus: 68.5686% (minimum 97%, Missing); heart muscle: 61.9910% (minimum 99%, Missing); hippocampal formation: 75.6906% (minimum 99%, Missing); hypothalamus: 76.7077% (minimum 99%, Missing); kidney: 56.7053% (minimum 99%, Missing); liver: 46.7896% (minimum 99%, Missing); lung: 69.8267% (minimum 99%, Missing); lymph node: 74.9453% (minimum 97%, Missing); midbrain: 75.3575% (minimum 99%, Missing); pancreas: 66.6991% (minimum 99%, Missing); parathyroid gland: 56.9410% (minimum 97%, Missing); pituitary gland: 71.5778% (minimum 99%, Missing); rectum: 62.6143% (minimum 97%, Missing); retina: 78.6452% (minimum 99%, Missing); salivary gland: 61.8790% (minimum 97%, Missing); skeletal muscle: 76.3657% (minimum 99%, Missing); skin: 78.8262% (minimum 95%, Missing); small intestine: 64.7448% (minimum 99%, Missing); smooth muscle: 61.2154% (minimum 97%, Supported); spinal cord: 66.3760% (minimum 99%, Missing); spleen: 73.0277% (minimum 95%, Missing); stomach: 62.9017% (minimum 97%, Missing); thymus: 78.2857% (minimum 95%, Missing); thyroid gland: 46.9500% (minimum 95%, Missing); tongue: 74.2145% (minimum 97%, Missing); urinary bladder: 65.3626% (minimum 97%, Missing)",0,4,partial,77.9,51.8,77.4,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (manageable, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 2); smooth muscle: 43.4 nTPM (vital, limit 3); salivary gland: 42.2 nTPM (protected, limit 2); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 2); colon: 40.7 nTPM (protected, limit 2); stomach: 40.4 nTPM (protected, limit 2); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 2); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (manageable, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 2); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); pituitary gland: 27.2 nTPM (vital, limit 1); spleen: 25.3 nTPM (manageable, limit 5); tongue: 23.8 nTPM (protected, limit 2); lymph node: 22.9 nTPM (protected, limit 2); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); thymus: 19 nTPM (manageable, limit 5); retina: 18.6 nTPM (vital, limit 1); skin: 18.4 nTPM (manageable, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 1 / vascular mural cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000134970,TMED7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4805,-0.40059,-0.522104
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,10.9,1,1.3,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000135119,RNFT2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.2609% (minimum 99%, Baseline (adaptation disabled)); amygdala: 35.6436% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 31.0345% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 78.2609% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 27.4809% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 24.8276% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 42.3529% (minimum 99%, Baseline (adaptation disabled)); colon: 92.3077% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.8049% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.3077% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 31.5789% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 29.7521% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.7209% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2973% (minimum 99%, Baseline (adaptation disabled)); lung: 92.3077% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.2609% (minimum 97%, Baseline (adaptation disabled)); midbrain: 34.9515% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.7368% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 41.8605% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.3077% (minimum 97%, Baseline (adaptation disabled)); retina: 42.8571% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.8049% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); skin: 85.7143% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.8049% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.7368% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 42.3529% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.8182% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.3077% (minimum 97%, Baseline (adaptation disabled)); thymus: 73.4694% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.8049% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.7368% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,10.9,1,1.3,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000135119,RNFT2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.215306,-0.187391,-0.741724
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 78.2609% (minimum 99%, Missing); amygdala: 35.6436% (minimum 99%, Missing); basal ganglia: 31.0345% (minimum 99%, Missing); bone marrow: 78.2609% (minimum 95%, Enhanced); cerebellum: 27.4809% (minimum 99%, Missing); cerebral cortex: 24.8276% (minimum 99%, Missing); choroid plexus: 42.3529% (minimum 99%, Missing); duodenum: 87.8049% (minimum 95%, Enhanced); heart muscle: 90.0000% (minimum 95%, Enhanced); hippocampal formation: 31.5789% (minimum 99%, Missing); hypothalamus: 29.7521% (minimum 99%, Missing); kidney: 83.7209% (minimum 95%, Enhanced); lung: 92.3077% (minimum 95%, Enhanced); lymph node: 78.2609% (minimum 97%, Missing); midbrain: 34.9515% (minimum 99%, Missing); pancreas: 94.7368% (minimum 95%, Enhanced); pituitary gland: 41.8605% (minimum 99%, Missing); retina: 42.8571% (minimum 99%, Missing); skeletal muscle: 85.7143% (minimum 95%, Enhanced); small intestine: 87.8049% (minimum 95%, Enhanced); smooth muscle: 94.7368% (minimum 95%, Enhanced); spinal cord: 42.3529% (minimum 99%, Missing); thymus: 73.4694% (minimum 95%, Missing); thyroid gland: 87.8049% (minimum 95%, Missing)",0,0,routine_complete,10.9,1,1.3,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000135119,RNFT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.215306,-0.187391,-0.741724
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000135175,OCM2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000135175,OCM2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000135175,OCM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,0,routine_complete,0.1,3.1,5.4,"thymus: 5.4 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000135222,CSN2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,0,routine_complete,0.1,3.1,5.4,"thymus: 5.4 nTPM (manageable, limit 5); salivary gland: 3.1 nTPM (protected, limit 2)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000135222,CSN2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.0404543,0.0244977,0.00982156
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,0,routine_complete,0.1,3.1,5.4,"thymus: 5.4 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000135222,CSN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.0404543,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000135248,GARIN1B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 98.9166% (minimum 99%, Baseline (adaptation disabled)); retina: 98.9166% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000135248,GARIN1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0489059,0.0289059,-0.000834236
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 98.9166% (minimum 99%, Missing); retina: 98.9166% (minimum 99%, Missing)",0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000135248,GARIN1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0489059,0.0289059,-0.000834236
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,14.2,2.1,2.3,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135314,KHDC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.0968% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.0110% (minimum 99%, Baseline (adaptation disabled)); amygdala: 42.4084% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 36.3229% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.5904% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 46.8208% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 37.1560% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.9421% (minimum 99%, Baseline (adaptation disabled)); colon: 84.3750% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.7805% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.6441% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 46.8208% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 46.2857% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.0110% (minimum 99%, Baseline (adaptation disabled)); liver: 98.7805% (minimum 99%, Baseline (adaptation disabled)); lung: 91.0112% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.1702% (minimum 97%, Baseline (adaptation disabled)); midbrain: 45.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.7009% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.4118% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 52.5974% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.2941% (minimum 97%, Baseline (adaptation disabled)); retina: 69.2308% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.1034% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.0435% (minimum 99%, Baseline (adaptation disabled)); small intestine: 91.0112% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.2895% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.0455% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.3750% (minimum 97%, Baseline (adaptation disabled)); thymus: 79.4118% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 77.8846% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.1702% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.1702% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,14.2,2.1,2.3,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135314,KHDC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.171154,-0.175882,-0.626771
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.0968% (minimum 95%, Missing); adrenal gland: 89.0110% (minimum 99%, Missing); amygdala: 42.4084% (minimum 99%, Missing); basal ganglia: 36.3229% (minimum 99%, Missing); bone marrow: 97.5904% (minimum 99%, Missing); cerebellum: 46.8208% (minimum 99%, Missing); cerebral cortex: 37.1560% (minimum 99%, Missing); choroid plexus: 66.9421% (minimum 99%, Missing); colon: 84.3750% (minimum 97%, Missing); duodenum: 98.7805% (minimum 99%, Missing); esophagus: 90.0000% (minimum 97%, Missing); heart muscle: 68.6441% (minimum 99%, Missing); hippocampal formation: 46.8208% (minimum 99%, Missing); hypothalamus: 46.2857% (minimum 99%, Missing); kidney: 89.0110% (minimum 99%, Missing); liver: 98.7805% (minimum 99%, Missing); lung: 91.0112% (minimum 99%, Missing); lymph node: 86.1702% (minimum 97%, Missing); midbrain: 45.0000% (minimum 99%, Missing); pancreas: 75.7009% (minimum 99%, Missing); parathyroid gland: 79.4118% (minimum 97%, Missing); pituitary gland: 52.5974% (minimum 99%, Missing); rectum: 95.2941% (minimum 97%, Missing); retina: 69.2308% (minimum 99%, Missing); salivary gland: 93.1034% (minimum 97%, Missing); skeletal muscle: 88.0435% (minimum 99%, Missing); small intestine: 91.0112% (minimum 99%, Missing); smooth muscle: 90.0000% (minimum 99%, Missing); spinal cord: 53.2895% (minimum 99%, Missing); spleen: 92.0455% (minimum 95%, Missing); stomach: 84.3750% (minimum 97%, Missing); thymus: 79.4118% (minimum 95%, Missing); thyroid gland: 77.8846% (minimum 95%, Missing); tongue: 86.1702% (minimum 97%, Missing); urinary bladder: 86.1702% (minimum 97%, Missing)",0,80,unavailable,14.2,2.1,2.3,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135314,KHDC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.171154,-0.175882,-0.626771
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,94,40.9,47.9,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); spleen: 47.9 nTPM (manageable, limit 5); tongue: 40.9 nTPM (protected, limit 2); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 2); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (manageable, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); thymus: 30.4 nTPM (manageable, limit 5); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 2); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); salivary gland: 23.8 nTPM (protected, limit 2); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 2); small intestine: 22.3 nTPM (vital, limit 1); skin: 22.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 2); parathyroid gland: 17.2 nTPM (protected, limit 2); thyroid gland: 16.7 nTPM (manageable, limit 5); stomach: 16.3 nTPM (protected, limit 2); smooth muscle: 15.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135334,AKIRIN2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.1125% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 41.1475% (minimum 99%, Baseline (adaptation disabled)); amygdala: 42.5424% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 43.1271% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 26.5048% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 47.8095% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 41.2151% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 50.7071% (minimum 99%, Baseline (adaptation disabled)); colon: 56.6591% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.9333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 43.7282% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 45.6364% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 43.6522% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 44.7415% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.4084% (minimum 99%, Baseline (adaptation disabled)); liver: 45.3069% (minimum 99%, Baseline (adaptation disabled)); lung: 43.8045% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.5379% (minimum 97%, Baseline (adaptation disabled)); midbrain: 46.0550% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.2269% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.3381% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 52.4008% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.4731% (minimum 97%, Baseline (adaptation disabled)); retina: 46.5677% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.3292% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 21.0747% (minimum 99%, Baseline (adaptation disabled)); skin: 53.0655% (minimum 95%, Baseline (adaptation disabled)); small intestine: 52.9536% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.3692% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 44.5826% (minimum 99%, Baseline (adaptation disabled)); spleen: 34.3836% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.6280% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.2252% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.0478% (minimum 95%, Baseline (adaptation disabled)); tongue: 38.0303% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.7311% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,94,40.9,47.9,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); spleen: 47.9 nTPM (manageable, limit 5); tongue: 40.9 nTPM (protected, limit 2); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 2); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (manageable, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); thymus: 30.4 nTPM (manageable, limit 5); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 2); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); salivary gland: 23.8 nTPM (protected, limit 2); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 2); small intestine: 22.3 nTPM (vital, limit 1); skin: 22.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 2); parathyroid gland: 17.2 nTPM (protected, limit 2); thyroid gland: 16.7 nTPM (manageable, limit 5); stomach: 16.3 nTPM (protected, limit 2); smooth muscle: 15.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135334,AKIRIN2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.606164,-0.589697,-0.779253
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.1125% (minimum 95%, Missing); adrenal gland: 41.1475% (minimum 99%, Missing); amygdala: 42.5424% (minimum 99%, Missing); basal ganglia: 43.1271% (minimum 99%, Missing); bone marrow: 26.5048% (minimum 99%, Missing); cerebellum: 47.8095% (minimum 99%, Missing); cerebral cortex: 41.2151% (minimum 99%, Missing); choroid plexus: 50.7071% (minimum 99%, Missing); colon: 56.6591% (minimum 97%, Missing); duodenum: 66.9333% (minimum 99%, Missing); esophagus: 43.7282% (minimum 97%, Missing); heart muscle: 45.6364% (minimum 99%, Missing); hippocampal formation: 43.6522% (minimum 99%, Missing); hypothalamus: 44.7415% (minimum 99%, Missing); kidney: 55.4084% (minimum 99%, Missing); liver: 45.3069% (minimum 99%, Missing); lung: 43.8045% (minimum 99%, Missing); lymph node: 47.5379% (minimum 97%, Missing); midbrain: 46.0550% (minimum 99%, Missing); pancreas: 66.2269% (minimum 99%, Missing); parathyroid gland: 59.3381% (minimum 97%, Missing); pituitary gland: 52.4008% (minimum 99%, Missing); rectum: 67.4731% (minimum 97%, Missing); retina: 46.5677% (minimum 99%, Missing); salivary gland: 51.3292% (minimum 97%, Missing); skeletal muscle: 21.0747% (minimum 99%, Missing); skin: 53.0655% (minimum 95%, Missing); small intestine: 52.9536% (minimum 99%, Missing); smooth muscle: 61.3692% (minimum 99%, Missing); spinal cord: 44.5826% (minimum 99%, Missing); spleen: 34.3836% (minimum 95%, Missing); stomach: 60.6280% (minimum 97%, Missing); thymus: 45.2252% (minimum 95%, Missing); thyroid gland: 60.0478% (minimum 95%, Missing); tongue: 38.0303% (minimum 97%, Missing); urinary bladder: 52.7311% (minimum 97%, Missing)",0,80,unavailable,94,40.9,47.9,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); spleen: 47.9 nTPM (manageable, limit 5); tongue: 40.9 nTPM (protected, limit 2); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 2); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (manageable, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); thymus: 30.4 nTPM (manageable, limit 5); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 2); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); salivary gland: 23.8 nTPM (protected, limit 2); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 2); small intestine: 22.3 nTPM (vital, limit 1); skin: 22.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 2); parathyroid gland: 17.2 nTPM (protected, limit 2); thyroid gland: 16.7 nTPM (manageable, limit 5); stomach: 16.3 nTPM (protected, limit 2); smooth muscle: 15.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135334,AKIRIN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.606164,-0.589697,-0.779253
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,13.9,16.7,6.1,"parathyroid gland: 16.7 nTPM (protected, limit 2); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); spinal cord: 6 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 3); lung: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135338,LCA5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.6098% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.7838% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.3824% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.8889% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.6562% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.4545% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.8889% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 40.0862% (minimum 99%, Baseline (adaptation disabled)); colon: 79.4872% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.2913% (minimum 99%, Baseline (adaptation disabled)); esophagus: 76.2295% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.1724% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.3913% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.9248% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 89.4231% (minimum 99%, Baseline (adaptation disabled)); lung: 70.4545% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.9159% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.9248% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.4872% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 35.7692% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.6562% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.1111% (minimum 97%, Baseline (adaptation disabled)); retina: 41.1504% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.2653% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.4231% (minimum 99%, Baseline (adaptation disabled)); skin: 90.2913% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.7358% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.9248% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 60.7843% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.3211% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.1111% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.2913% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.3896% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.0357% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.8095% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,13.9,16.7,6.1,"parathyroid gland: 16.7 nTPM (protected, limit 2); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); spinal cord: 6 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135338,LCA5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.346104,-0.612308,-0.589138
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.6098% (minimum 80%, Supported); adrenal gland: 83.7838% (minimum 99%, Missing); amygdala: 68.3824% (minimum 99%, Missing); basal ganglia: 68.8889% (minimum 99%, Missing); bone marrow: 72.6562% (minimum 99%, Missing); cerebellum: 70.4545% (minimum 97%, Supported); cerebral cortex: 68.8889% (minimum 99%, Missing); choroid plexus: 40.0862% (minimum 99%, Missing); colon: 79.4872% (minimum 97%, Missing); duodenum: 90.2913% (minimum 99%, Missing); esophagus: 76.2295% (minimum 97%, Missing); heart muscle: 80.1724% (minimum 99%, Missing); hippocampal formation: 67.3913% (minimum 99%, Missing); hypothalamus: 69.9248% (minimum 99%, Missing); kidney: 77.5000% (minimum 99%, Missing); liver: 89.4231% (minimum 99%, Missing); lung: 70.4545% (minimum 99%, Missing); lymph node: 86.9159% (minimum 90%, Supported); midbrain: 69.9248% (minimum 99%, Missing); pancreas: 79.4872% (minimum 99%, Missing); parathyroid gland: 35.7692% (minimum 97%, Missing); pituitary gland: 72.6562% (minimum 99%, Missing); rectum: 86.1111% (minimum 97%, Missing); retina: 41.1504% (minimum 99%, Missing); salivary gland: 63.2653% (minimum 97%, Missing); skeletal muscle: 89.4231% (minimum 99%, Missing); small intestine: 87.7358% (minimum 99%, Missing); smooth muscle: 69.9248% (minimum 97%, Supported); spinal cord: 60.7843% (minimum 99%, Missing); stomach: 86.1111% (minimum 97%, Missing); thymus: 90.2913% (minimum 95%, Missing); thyroid gland: 60.3896% (minimum 95%, Missing); tongue: 83.0357% (minimum 97%, Missing); urinary bladder: 73.8095% (minimum 97%, Missing)",0,5,partial,13.9,16.7,6.1,"parathyroid gland: 16.7 nTPM (protected, limit 2); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); spinal cord: 6 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 3); lung: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135338,LCA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.346104,-0.612308,-0.589138
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,ENSG00000135355,GJA10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 30.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,ENSG00000135355,GJA10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.69
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 30.0000% (minimum 99%, Missing)",0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,ENSG00000135355,GJA10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.69
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,1.5,0.9,1.1,"pancreas: 1.5 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135436,FAM186B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8938% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.8938% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.2418% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8938% (minimum 99%, Baseline (adaptation disabled)); liver: 98.4581% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7532% (minimum 99%, Baseline (adaptation disabled)); retina: 98.6755% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.6755% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.5,0.9,1.1,"pancreas: 1.5 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135436,FAM186B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,0.0259825,0.0102632,-0.0224675
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8938% (minimum 99%, Uncertain); bone marrow: 98.8938% (minimum 99%, Uncertain); choroid plexus: 98.2418% (minimum 99%, Missing); kidney: 98.8938% (minimum 99%, Uncertain); liver: 98.4581% (minimum 99%, Uncertain); pancreas: 96.7532% (minimum 99%, Uncertain); retina: 98.6755% (minimum 99%, Missing); skeletal muscle: 98.6755% (minimum 99%, Uncertain)",0,3,partial,1.5,0.9,1.1,"pancreas: 1.5 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135436,FAM186B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,0.0259825,0.0102632,-0.0224675
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,50.5,13.2,35.9,"bone marrow: 50.5 nTPM (vital, limit 1); thymus: 35.9 nTPM (manageable, limit 5); esophagus: 13.2 nTPM (protected, limit 2); lymph node: 11 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); duodenum: 8.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.3 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); colon: 6.5 nTPM (protected, limit 2); stomach: 5.2 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135451,TROAP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.2862% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 35.9137% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.9510% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 81.3218% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.4865% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.1928% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.5862% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.9178% (minimum 99%, Baseline (adaptation disabled)); liver: 94.6488% (minimum 99%, Baseline (adaptation disabled)); lung: 92.4837% (minimum 99%, Baseline (adaptation disabled)); lymph node: 72.0102% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.9510% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.2509% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.6063% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.0753% (minimum 97%, Baseline (adaptation disabled)); retina: 97.9239% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.1824% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.9510% (minimum 99%, Baseline (adaptation disabled)); skin: 79.0503% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.4944% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.2903% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9510% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.3977% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.4776% (minimum 97%, Baseline (adaptation disabled)); thymus: 44.0810% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.0199% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,50.5,13.2,35.9,"bone marrow: 50.5 nTPM (vital, limit 1); thymus: 35.9 nTPM (manageable, limit 5); esophagus: 13.2 nTPM (protected, limit 2); lymph node: 11 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); duodenum: 8.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.3 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); colon: 6.5 nTPM (protected, limit 2); stomach: 5.2 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135451,TROAP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.50919,-0.288072,-0.630863
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.2862% (minimum 99%, Missing); bone marrow: 35.9137% (minimum 99%, Missing); cerebral cortex: 98.9510% (minimum 99%, Missing); choroid plexus: 94.3333% (minimum 99%, Missing); colon: 81.3218% (minimum 97%, Missing); duodenum: 76.4865% (minimum 99%, Missing); esophagus: 68.1928% (minimum 97%, Missing); heart muscle: 97.5862% (minimum 99%, Missing); kidney: 96.9178% (minimum 99%, Missing); liver: 94.6488% (minimum 99%, Uncertain); lung: 92.4837% (minimum 99%, Missing); lymph node: 72.0102% (minimum 97%, Missing); midbrain: 98.9510% (minimum 99%, Missing); pancreas: 97.2509% (minimum 99%, Missing); pituitary gland: 98.6063% (minimum 99%, Missing); rectum: 76.0753% (minimum 97%, Missing); retina: 97.9239% (minimum 99%, Missing); salivary gland: 92.1824% (minimum 97%, Missing); skeletal muscle: 98.9510% (minimum 99%, Missing); skin: 79.0503% (minimum 95%, Missing); small intestine: 79.4944% (minimum 99%, Missing); smooth muscle: 91.2903% (minimum 99%, Uncertain); spinal cord: 98.9510% (minimum 99%, Missing); spleen: 80.3977% (minimum 95%, Missing); stomach: 84.4776% (minimum 97%, Missing); thymus: 44.0810% (minimum 95%, Missing); urinary bladder: 94.0199% (minimum 97%, Missing)",0,3,partial,50.5,13.2,35.9,"bone marrow: 50.5 nTPM (vital, limit 1); thymus: 35.9 nTPM (manageable, limit 5); esophagus: 13.2 nTPM (protected, limit 2); lymph node: 11 nTPM (protected, limit 2); rectum: 8.9 nTPM (protected, limit 2); duodenum: 8.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.3 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); colon: 6.5 nTPM (protected, limit 2); stomach: 5.2 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135451,TROAP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.50919,-0.288072,-0.630863
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,4.8,5.1,2.9,"parathyroid gland: 5.1 nTPM (protected, limit 4); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135537,AFG1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.8710% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.1356% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.2000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.7879% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.3893% (minimum 99%, Baseline (adaptation disabled)); colon: 81.2500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.7241% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.3950% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.7483% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.8889% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.6552% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.4211% (minimum 99%, Baseline (adaptation disabled)); liver: 74.2857% (minimum 99%, Baseline (adaptation disabled)); lung: 85.9504% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.2459% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.1356% (minimum 99%, Baseline (adaptation disabled)); pancreas: 83.8710% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 67.0968% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.3950% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.6119% (minimum 97%, Baseline (adaptation disabled)); retina: 78.1955% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.9504% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 74.8201% (minimum 99%, Baseline (adaptation disabled)); skin: 90.4348% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.1955% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.9504% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.3950% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.8710% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.5397% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.1955% (minimum 95%, Baseline (adaptation disabled)); tongue: 72.7273% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.6667% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,4.8,5.1,2.9,"parathyroid gland: 5.1 nTPM (protected, limit 2); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135537,AFG1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.168045,-0.299032,-0.305789
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.6667% (minimum 90%, Approved); adrenal gland: 83.8710% (minimum 99%, Missing); amygdala: 88.1356% (minimum 99%, Missing); basal ganglia: 86.6667% (minimum 99%, Missing); bone marrow: 83.2000% (minimum 99%, Missing); cerebellum: 88.8889% (minimum 99%, Missing); cerebral cortex: 78.7879% (minimum 99%, Missing); choroid plexus: 79.3893% (minimum 99%, Missing); colon: 81.2500% (minimum 97%, Missing); duodenum: 71.7241% (minimum 99%, Missing); esophagus: 87.3950% (minimum 97%, Missing); heart muscle: 70.7483% (minimum 99%, Missing); hippocampal formation: 88.8889% (minimum 99%, Missing); hypothalamus: 89.6552% (minimum 99%, Missing); kidney: 68.4211% (minimum 99%, Missing); liver: 74.2857% (minimum 99%, Missing); lung: 85.9504% (minimum 99%, Missing); lymph node: 85.2459% (minimum 95%, Approved); midbrain: 88.1356% (minimum 99%, Missing); pancreas: 83.8710% (minimum 99%, Missing); parathyroid gland: 67.0968% (minimum 95%, Approved); pituitary gland: 87.3950% (minimum 99%, Missing); rectum: 77.6119% (minimum 97%, Missing); retina: 78.1955% (minimum 99%, Missing); salivary gland: 85.9504% (minimum 97%, Missing); skeletal muscle: 74.8201% (minimum 99%, Missing); skin: 90.4348% (minimum 95%, Missing); small intestine: 78.1955% (minimum 99%, Missing); smooth muscle: 85.9504% (minimum 99%, Missing); spinal cord: 87.3950% (minimum 99%, Missing); spleen: 83.8710% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thymus: 82.5397% (minimum 95%, Missing); thyroid gland: 78.1955% (minimum 95%, Missing); tongue: 72.7273% (minimum 97%, Missing); urinary bladder: 86.6667% (minimum 97%, Missing)",0,5,partial,4.8,5.1,2.9,"parathyroid gland: 5.1 nTPM (protected, limit 4); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135537,AFG1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.168045,-0.279032,-0.305789
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.4,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000135577,NMBR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 87.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 63.6364% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.5000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.5000% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 87.5000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 87.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 77.7778% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.5000% (minimum 97%, Baseline (adaptation disabled)); spinal cord: 87.5000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000135577,NMBR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,-0.095,-0.353636
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 63.6364% (minimum 99%, Missing); cerebral cortex: 87.5000% (minimum 99%, Missing); esophagus: 87.5000% (minimum 97%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing); hypothalamus: 70.0000% (minimum 99%, Missing); midbrain: 87.5000% (minimum 99%, Missing); retina: 77.7778% (minimum 99%, Missing); salivary gland: 87.5000% (minimum 97%, Missing); spinal cord: 87.5000% (minimum 99%, Missing)",0,80,unavailable,0.4,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000135577,NMBR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,-0.095,-0.353636
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,18.6,0.1,0.2,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),56,not_established,required,in_situ_inflammation_review,appendix,ENSG00000135625,EGR4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.4359% (minimum 99%, Baseline (adaptation disabled)); amygdala: 42.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 25.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.4359% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 16.9643% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 35.5140% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.0000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 92.6829% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 28.1481% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 56.7164% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 52.7778% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.3721% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,18.6,0.1,0.2,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),56,not_established,required,in_situ_inflammation_review,appendix,ENSG00000135625,EGR4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0,0.00435897,-0.820357
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.2222% (minimum 99%, Missing); basal ganglia: 25.3333% (minimum 99%, Missing); cerebellum: 16.9643% (minimum 99%, Missing); cerebral cortex: 35.5140% (minimum 99%, Missing); choroid plexus: 95.0000% (minimum 99%, Missing); heart muscle: 92.6829% (minimum 95%, Enhanced); hippocampal formation: 28.1481% (minimum 99%, Missing); hypothalamus: 56.7164% (minimum 99%, Missing); midbrain: 95.0000% (minimum 99%, Missing); pituitary gland: 52.7778% (minimum 99%, Missing); spinal cord: 88.3721% (minimum 99%, Missing)",0,0,routine_complete,18.6,0.1,0.2,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),56,not_established,required,in_situ_inflammation_review,appendix,ENSG00000135625,EGR4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.820357
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,29.5,0.1,6.4,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,ENSG00000135824,RGS8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.6842% (minimum 99%, Baseline (adaptation disabled)); amygdala: 45.1613% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 9.5563% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 23.1405% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 45.9016% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.6757% (minimum 99%, Baseline (adaptation disabled)); colon: 96.5517% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 54.9020% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 31.4607% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.5517% (minimum 97%, Baseline (adaptation disabled)); midbrain: 25.6881% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 8.6687% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.5517% (minimum 97%, Baseline (adaptation disabled)); smooth muscle: 96.5517% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 40.5797% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 30.4348% (minimum 95%, Baseline (adaptation disabled))",0,7,partial,29.5,0.1,6.4,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,ENSG00000135824,RGS8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.645652,-0.00448276,-0.903313
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.6842% (minimum 95%, Enhanced); amygdala: 45.1613% (minimum 99%, Missing); basal ganglia: 9.5563% (minimum 99%, Missing); cerebellum: 23.1405% (minimum 99%, Missing); cerebral cortex: 45.9016% (minimum 95%, Enhanced); choroid plexus: 75.6757% (minimum 99%, Missing); colon: 96.5517% (minimum 97%, Missing); hippocampal formation: 54.9020% (minimum 99%, Missing); hypothalamus: 31.4607% (minimum 99%, Missing); midbrain: 25.6881% (minimum 99%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); retina: 8.6687% (minimum 99%, Missing); spinal cord: 40.5797% (minimum 99%, Missing); thyroid gland: 30.4348% (minimum 60%, Enhanced)",0,7,partial,29.5,0.1,6.4,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,ENSG00000135824,RGS8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.295652,-0.00448276,-0.903313
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,129.8,66,86.3,"bone marrow: 129.8 nTPM (vital, limit 1); thymus: 86.3 nTPM (manageable, limit 5); parathyroid gland: 66 nTPM (protected, limit 2); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 2); urinary bladder: 52 nTPM (protected, limit 2); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (manageable, limit 5); rectum: 45.7 nTPM (protected, limit 2); spleen: 39.8 nTPM (manageable, limit 5); colon: 38.9 nTPM (protected, limit 2); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (manageable, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 2); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 2); duodenum: 31.7 nTPM (vital, limit 1); salivary gland: 31.6 nTPM (protected, limit 2); esophagus: 31.2 nTPM (protected, limit 2); skin: 30.3 nTPM (manageable, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135829,DHX9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.9955% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.5018% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.6767% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.4514% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 28.4060% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 58.7900% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.0609% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.5479% (minimum 99%, Baseline (adaptation disabled)); colon: 56.9690% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.8990% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.2733% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.1899% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0729% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.0496% (minimum 99%, Baseline (adaptation disabled)); kidney: 51.6550% (minimum 99%, Baseline (adaptation disabled)); liver: 58.9920% (minimum 99%, Baseline (adaptation disabled)); lung: 57.9303% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.0859% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.3146% (minimum 99%, Baseline (adaptation disabled)); pancreas: 63.5018% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 43.8298% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.5278% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.9835% (minimum 97%, Baseline (adaptation disabled)); retina: 44.4349% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.9735% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.8166% (minimum 99%, Baseline (adaptation disabled)); skin: 62.9584% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.3318% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 51.2948% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.7832% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.4074% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.5170% (minimum 97%, Baseline (adaptation disabled)); thymus: 37.3730% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.4975% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.6560% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 49.7585% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,129.8,66,86.3,"bone marrow: 129.8 nTPM (vital, limit 1); thymus: 86.3 nTPM (manageable, limit 5); parathyroid gland: 66 nTPM (protected, limit 2); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 2); urinary bladder: 52 nTPM (protected, limit 2); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (manageable, limit 5); rectum: 45.7 nTPM (protected, limit 2); spleen: 39.8 nTPM (manageable, limit 5); colon: 38.9 nTPM (protected, limit 2); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (manageable, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 2); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 2); duodenum: 31.7 nTPM (vital, limit 1); salivary gland: 31.6 nTPM (protected, limit 2); esophagus: 31.2 nTPM (protected, limit 2); skin: 30.3 nTPM (manageable, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135829,DHX9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.57627,-0.531702,-0.70594
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.9955% (minimum 95%, Missing); adrenal gland: 63.5018% (minimum 99%, Missing); amygdala: 73.6767% (minimum 99%, Missing); basal ganglia: 70.4514% (minimum 99%, Missing); bone marrow: 28.4060% (minimum 99%, Missing); cerebellum: 58.7900% (minimum 99%, Missing); cerebral cortex: 58.0609% (minimum 99%, Missing); choroid plexus: 70.5479% (minimum 99%, Missing); colon: 56.9690% (minimum 97%, Missing); duodenum: 61.8990% (minimum 99%, Missing); esophagus: 62.2733% (minimum 97%, Missing); heart muscle: 65.1899% (minimum 99%, Missing); hippocampal formation: 75.0729% (minimum 99%, Missing); hypothalamus: 73.0496% (minimum 99%, Missing); kidney: 51.6550% (minimum 99%, Missing); liver: 58.9920% (minimum 99%, Missing); lung: 57.9303% (minimum 99%, Missing); lymph node: 48.0859% (minimum 97%, Missing); midbrain: 74.3146% (minimum 99%, Missing); pancreas: 63.5018% (minimum 99%, Missing); parathyroid gland: 43.8298% (minimum 97%, Missing); pituitary gland: 71.5278% (minimum 99%, Missing); rectum: 52.9835% (minimum 97%, Missing); retina: 44.4349% (minimum 99%, Missing); salivary gland: 61.9735% (minimum 97%, Missing); skeletal muscle: 63.8166% (minimum 99%, Missing); skin: 62.9584% (minimum 95%, Missing); small intestine: 59.3318% (minimum 99%, Missing); smooth muscle: 51.2948% (minimum 99%, Missing); spinal cord: 69.7832% (minimum 99%, Missing); spleen: 56.4074% (minimum 95%, Missing); stomach: 60.5170% (minimum 97%, Missing); thymus: 37.3730% (minimum 95%, Missing); thyroid gland: 52.4975% (minimum 95%, Missing); tongue: 58.6560% (minimum 97%, Missing); urinary bladder: 49.7585% (minimum 97%, Missing)",0,4,partial,129.8,66,86.3,"bone marrow: 129.8 nTPM (vital, limit 1); thymus: 86.3 nTPM (manageable, limit 5); parathyroid gland: 66 nTPM (protected, limit 2); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 2); urinary bladder: 52 nTPM (protected, limit 2); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (manageable, limit 5); rectum: 45.7 nTPM (protected, limit 2); spleen: 39.8 nTPM (manageable, limit 5); colon: 38.9 nTPM (protected, limit 2); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (manageable, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 2); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 2); duodenum: 31.7 nTPM (vital, limit 1); salivary gland: 31.6 nTPM (protected, limit 2); esophagus: 31.2 nTPM (protected, limit 2); skin: 30.3 nTPM (manageable, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135829,DHX9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.57627,-0.531702,-0.70594
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.5,2.8,4,"basal ganglia: 3.5 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135898,GPR55,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.7447% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.2500% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.7447% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.5385% (minimum 99%, Baseline (adaptation disabled)); colon: 84.9057% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.5862% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.8261% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.7500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.7500% (minimum 99%, Baseline (adaptation disabled)); liver: 95.7447% (minimum 99%, Baseline (adaptation disabled)); lung: 90.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.6438% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.8261% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.8367% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.9057% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 81.8182% (minimum 97%, Baseline (adaptation disabled)); skin: 91.8367% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.1818% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.8261% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.8261% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.9412% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.5385% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.3125% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 84.9057% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.5,2.8,4,"basal ganglia: 3.5 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135898,GPR55,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.420588,-0.353562,-0.4275
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.7447% (minimum 99%, Missing); basal ganglia: 56.2500% (minimum 99%, Missing); bone marrow: 95.7447% (minimum 99%, Missing); cerebral cortex: 86.5385% (minimum 99%, Missing); colon: 84.9057% (minimum 97%, Missing); duodenum: 77.5862% (minimum 99%, Missing); esophagus: 90.0000% (minimum 97%, Missing); heart muscle: 97.8261% (minimum 99%, Missing); hippocampal formation: 93.7500% (minimum 99%, Missing); hypothalamus: 93.7500% (minimum 99%, Missing); liver: 95.7447% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); lymph node: 61.6438% (minimum 97%, Missing); midbrain: 97.8261% (minimum 99%, Missing); pituitary gland: 91.8367% (minimum 99%, Missing); rectum: 84.9057% (minimum 97%, Missing); salivary gland: 81.8182% (minimum 97%, Missing); skin: 91.8367% (minimum 95%, Missing); small intestine: 68.1818% (minimum 99%, Missing); smooth muscle: 97.8261% (minimum 99%, Missing); spinal cord: 97.8261% (minimum 99%, Missing); spleen: 52.9412% (minimum 95%, Missing); stomach: 86.5385% (minimum 97%, Missing); thymus: 70.3125% (minimum 95%, Missing); urinary bladder: 84.9057% (minimum 97%, Missing)",0,80,unavailable,3.5,2.8,4,"basal ganglia: 3.5 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135898,GPR55,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.420588,-0.353562,-0.4275
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,11.5,5.8,6.1,"bone marrow: 11.5 nTPM (vital, limit 2); retina: 8.6 nTPM (vital, limit 1); thymus: 6.1 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 2); tongue: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 2); liver: 3.7 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); small intestine: 3.3 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135913,USP37,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.5503% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.4601% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.1818% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.4812% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 51.6807% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.8750% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.7810% (minimum 99%, Baseline (adaptation disabled)); colon: 80.9211% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.9211% (minimum 99%, Baseline (adaptation disabled)); esophagus: 76.3975% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.8276% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.1818% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.1818% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.4570% (minimum 99%, Baseline (adaptation disabled)); liver: 76.8750% (minimum 99%, Baseline (adaptation disabled)); lung: 80.9211% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.9558% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.1818% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.9211% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 76.3975% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 89.7810% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.3439% (minimum 97%, Baseline (adaptation disabled)); retina: 58.8517% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.8750% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 76.8750% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.8462% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 79.8701% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.6197% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.8750% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.8462% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.8478% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.9298% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.8481% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,11.5,5.8,6.1,"bone marrow: 11.5 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); thymus: 6.1 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 2); tongue: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 2); liver: 3.7 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); small intestine: 3.3 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135913,USP37,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.281522,-0.290442,-0.473193
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.5503% (minimum 95%, Missing); adrenal gland: 75.4601% (minimum 99%, Missing); amygdala: 93.1818% (minimum 99%, Missing); basal ganglia: 92.4812% (minimum 99%, Missing); bone marrow: 51.6807% (minimum 98%, Approved); cerebellum: 82.0000% (minimum 99%, Missing); cerebral cortex: 76.8750% (minimum 99%, Missing); choroid plexus: 89.7810% (minimum 99%, Missing); colon: 80.9211% (minimum 97%, Missing); duodenum: 80.9211% (minimum 99%, Missing); esophagus: 76.3975% (minimum 97%, Missing); heart muscle: 84.8276% (minimum 99%, Missing); hippocampal formation: 93.1818% (minimum 99%, Missing); hypothalamus: 93.1818% (minimum 99%, Missing); kidney: 81.4570% (minimum 99%, Missing); liver: 76.8750% (minimum 99%, Missing); lung: 80.9211% (minimum 99%, Missing); lymph node: 67.9558% (minimum 97%, Missing); midbrain: 93.1818% (minimum 99%, Missing); pancreas: 80.9211% (minimum 99%, Missing); parathyroid gland: 76.3975% (minimum 97%, Missing); pituitary gland: 89.7810% (minimum 99%, Missing); rectum: 78.3439% (minimum 97%, Missing); retina: 58.8517% (minimum 99%, Missing); salivary gland: 76.8750% (minimum 97%, Missing); skeletal muscle: 82.0000% (minimum 98%, Approved); skin: 76.8750% (minimum 95%, Missing); small intestine: 78.8462% (minimum 99%, Missing); smooth muscle: 79.8701% (minimum 99%, Missing); spinal cord: 86.6197% (minimum 99%, Missing); spleen: 76.8750% (minimum 90%, Approved); stomach: 78.8462% (minimum 97%, Missing); thymus: 66.8478% (minimum 95%, Missing); thyroid gland: 71.9298% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 77.8481% (minimum 97%, Missing)",0,6,partial,11.5,5.8,6.1,"bone marrow: 11.5 nTPM (vital, limit 2); retina: 8.6 nTPM (vital, limit 1); thymus: 6.1 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 2); tongue: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 2); liver: 3.7 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); small intestine: 3.3 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000135913,USP37,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.281522,-0.290442,-0.463193
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.1,1.5,3,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135951,TSGA10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2353% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.8516% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.4708% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6220% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6220% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.1729% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.0431% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.3462% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.9052% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.3503% (minimum 99%, Baseline (adaptation disabled)); lung: 96.9052% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.4708% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7181% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.4286% (minimum 99%, Baseline (adaptation disabled)); retina: 95.2471% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8166% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.0930% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 94.3503% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.1,1.5,3,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135951,TSGA10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00649718,0.000930233,-0.0482707
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2353% (minimum 99%, Missing); amygdala: 97.8516% (minimum 99%, Missing); basal ganglia: 97.4708% (minimum 99%, Missing); bone marrow: 98.6220% (minimum 99%, Missing); cerebral cortex: 98.6220% (minimum 99%, Missing); choroid plexus: 94.1729% (minimum 99%, Missing); duodenum: 98.0431% (minimum 99%, Missing); hippocampal formation: 96.3462% (minimum 99%, Missing); hypothalamus: 96.9052% (minimum 99%, Missing); kidney: 94.3503% (minimum 99%, Missing); lung: 96.9052% (minimum 99%, Missing); midbrain: 97.4708% (minimum 99%, Missing); pancreas: 96.7181% (minimum 99%, Missing); pituitary gland: 95.4286% (minimum 99%, Missing); retina: 95.2471% (minimum 99%, Missing); small intestine: 98.8166% (minimum 99%, Missing); spinal cord: 97.0930% (minimum 99%, Missing); thyroid gland: 94.3503% (minimum 95%, Missing)",0,80,unavailable,3.1,1.5,3,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000135951,TSGA10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00649718,0.000930233,-0.0482707
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,1,3.5,1.4,"esophagus: 3.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000135960,EDAR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 82.3529% (minimum 99%, Baseline (adaptation disabled)); colon: 53.8462% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 28.5714% (minimum 97%, Baseline (adaptation disabled)); kidney: 70.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 60.8696% (minimum 99%, Baseline (adaptation disabled)); lung: 87.5000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.2759% (minimum 97%, Baseline (adaptation disabled)); pancreas: 93.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 42.4242% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 73.6842% (minimum 97%, Baseline (adaptation disabled)); skin: 50.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 58.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.6364% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 50.0000% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,1,3.5,1.4,"esophagus: 3.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000135960,EDAR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.684286,-0.406667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 82.3529% (minimum 99%, Missing); colon: 53.8462% (minimum 97%, Missing); duodenum: 58.3333% (minimum 99%, Missing); esophagus: 28.5714% (minimum 97%, Missing); kidney: 70.0000% (minimum 99%, Missing); liver: 60.8696% (minimum 99%, Missing); lung: 87.5000% (minimum 99%, Missing); lymph node: 48.2759% (minimum 97%, Missing); pancreas: 93.3333% (minimum 99%, Missing); rectum: 42.4242% (minimum 97%, Missing); salivary gland: 73.6842% (minimum 97%, Missing); skin: 50.0000% (minimum 95%, Missing); small intestine: 58.3333% (minimum 99%, Missing); spleen: 87.5000% (minimum 95%, Missing); stomach: 63.6364% (minimum 97%, Missing); thymus: 56.0000% (minimum 95%, Missing); urinary bladder: 50.0000% (minimum 97%, Missing)",0,4,partial,1,3.5,1.4,"esophagus: 3.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000135960,EDAR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.684286,-0.406667
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.9,1.6,3.6,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136014,USP44,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9167% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.3264% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.7395% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.7395% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.7664% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.3264% (minimum 99%, Baseline (adaptation disabled)); colon: 95.5285% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.9167% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.3264% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7395% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.7581% (minimum 99%, Baseline (adaptation disabled)); lung: 86.3971% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.9184% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.7395% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.0853% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.6255% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.1417% (minimum 99%, Baseline (adaptation disabled)); retina: 93.6255% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.9184% (minimum 97%, Baseline (adaptation disabled)); small intestine: 96.7078% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.7078% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7395% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.0000% (minimum 95%, Baseline (adaptation disabled)); thymus: 86.7159% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.9,1.6,3.6,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136014,USP44,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0828413,-0.033745,-0.132336
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9167% (minimum 99%, Missing); amygdala: 98.3264% (minimum 99%, Missing); basal ganglia: 98.7395% (minimum 99%, Missing); bone marrow: 98.7395% (minimum 99%, Missing); cerebellum: 85.7664% (minimum 99%, Missing); cerebral cortex: 98.3264% (minimum 99%, Missing); colon: 95.5285% (minimum 97%, Missing); heart muscle: 97.9167% (minimum 99%, Missing); hippocampal formation: 98.3264% (minimum 99%, Missing); hypothalamus: 98.7395% (minimum 99%, Missing); kidney: 94.7581% (minimum 99%, Missing); lung: 86.3971% (minimum 99%, Missing); lymph node: 95.9184% (minimum 97%, Missing); midbrain: 98.7395% (minimum 99%, Missing); pancreas: 91.0853% (minimum 99%, Missing); parathyroid gland: 93.6255% (minimum 97%, Missing); pituitary gland: 95.1417% (minimum 99%, Missing); retina: 93.6255% (minimum 99%, Missing); salivary gland: 95.9184% (minimum 97%, Missing); small intestine: 96.7078% (minimum 99%, Missing); smooth muscle: 96.7078% (minimum 99%, Missing); spinal cord: 98.7395% (minimum 99%, Missing); spleen: 94.0000% (minimum 95%, Missing); thymus: 86.7159% (minimum 95%, Missing)",0,80,unavailable,3.9,1.6,3.6,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136014,USP44,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0828413,-0.033745,-0.132336
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,2.4,2.7,2.7,"parathyroid gland: 2.7 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000136197,C7orf25,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.0851% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.1111% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.2105% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.3061% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.5385% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.3061% (minimum 99%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.4286% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.5385% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.3061% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.3774% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 99%, Baseline (adaptation disabled)); liver: 69.5652% (minimum 99%, Baseline (adaptation disabled)); lung: 69.5652% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 59.2593% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 54.2373% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.5652% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.0488% (minimum 97%, Baseline (adaptation disabled)); retina: 68.0851% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.0851% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 74.4186% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.7273% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.3061% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.2593% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.3061% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.0851% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.2373% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.7451% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 74.4186% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,2.4,2.7,2.7,"parathyroid gland: 2.7 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000136197,C7orf25,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.407627,-0.427627,-0.418571
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.0851% (minimum 95%, Missing); adrenal gland: 71.1111% (minimum 99%, Missing); amygdala: 64.0000% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 84.2105% (minimum 99%, Missing); cerebellum: 65.3061% (minimum 99%, Missing); cerebral cortex: 61.5385% (minimum 99%, Missing); choroid plexus: 65.3061% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 91.4286% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 61.5385% (minimum 99%, Missing); hippocampal formation: 65.3061% (minimum 99%, Missing); hypothalamus: 60.3774% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); liver: 69.5652% (minimum 99%, Missing); lung: 69.5652% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 59.2593% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 54.2373% (minimum 97%, Missing); pituitary gland: 69.5652% (minimum 99%, Missing); rectum: 78.0488% (minimum 97%, Missing); retina: 68.0851% (minimum 99%, Missing); salivary gland: 68.0851% (minimum 97%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 74.4186% (minimum 95%, Missing); small intestine: 72.7273% (minimum 99%, Missing); smooth muscle: 65.3061% (minimum 98%, Approved); spinal cord: 59.2593% (minimum 99%, Missing); spleen: 65.3061% (minimum 95%, Missing); stomach: 64.0000% (minimum 97%, Missing); thymus: 68.0851% (minimum 95%, Missing); thyroid gland: 54.2373% (minimum 95%, Missing); tongue: 62.7451% (minimum 97%, Missing); urinary bladder: 74.4186% (minimum 97%, Missing)",0,2,partial,2.4,2.7,2.7,"parathyroid gland: 2.7 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000136197,C7orf25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.407627,-0.427627,-0.418571
True,compatible,,True,True,False,,0,3,partial,1.5,0.6,1.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000136206,SPDYE1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.1014% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5294% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5294% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.7073% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.1014% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.1014% (minimum 99%, Baseline (adaptation disabled)); duodenum: 93.0556% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.7143% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.1014% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5294% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5294% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.1014% (minimum 99%, Baseline (adaptation disabled)); liver: 97.1014% (minimum 99%, Baseline (adaptation disabled)); lung: 97.1014% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.7808% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.5294% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.7143% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1014% (minimum 99%, Baseline (adaptation disabled)); retina: 91.7808% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.3662% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.7500% (minimum 99%, Baseline (adaptation disabled)); skin: 84.8101% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.7808% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5294% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.0556% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.7143% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,1.5,0.6,1.2,"bone marrow: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000136206,SPDYE1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.101899,-0.0521918,-0.172927
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.5294% (minimum 99%, Missing); basal ganglia: 98.5294% (minimum 99%, Missing); bone marrow: 81.7073% (minimum 97%, Supported); duodenum: 93.0556% (minimum 97%, Supported); hippocampal formation: 98.5294% (minimum 99%, Missing); hypothalamus: 98.5294% (minimum 99%, Missing); midbrain: 98.5294% (minimum 99%, Missing); pancreas: 95.7143% (minimum 97%, Supported); pituitary gland: 97.1014% (minimum 99%, Missing); retina: 91.7808% (minimum 99%, Missing); skeletal muscle: 83.7500% (minimum 97%, Supported); small intestine: 91.7808% (minimum 97%, Supported); spinal cord: 98.5294% (minimum 99%, Missing)",0,3,partial,1.5,0.6,1.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000136206,SPDYE1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0481013,0.0178082,-0.152927
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,0.7,4.1,1.5,"lymph node: 4.1 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000136231,IGF2BP3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Bradley 2020,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 97.8947% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.5524% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.3110% (minimum 97%, Baseline (adaptation disabled)); liver: 98.2394% (minimum 99%, Baseline (adaptation disabled)); lung: 98.2394% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.1875% (minimum 97%, Baseline (adaptation disabled)); pancreas: 97.8947% (minimum 99%, Baseline (adaptation disabled)); thymus: 94.8980% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,0.7,4.1,1.5,"lymph node: 4.1 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000136231,IGF2BP3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Bradley 2020,-0.00102041,-0.098125,-0.0144755
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 97.5524% (minimum 99%, Missing); lymph node: 87.1875% (minimum 97%, Missing); thymus: 94.8980% (minimum 95%, Missing)",0,4,partial,0.7,4.1,1.5,"lymph node: 4.1 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000136231,IGF2BP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Bradley 2020,-0.00102041,-0.098125,-0.0144755
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.6,2.5,1.4,"spinal cord: 7.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000136327,NKX2-8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.7179% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.2500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7179% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.4902% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 97.4684% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.6154% (minimum 99%, Baseline (adaptation disabled)); lung: 96.2500% (minimum 99%, Baseline (adaptation disabled)); midbrain: 84.6154% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.3268% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 84.6154% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,7.6,2.5,1.4,"spinal cord: 7.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000136327,NKX2-8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.103846,-0.215098,-0.486732
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.7179% (minimum 99%, Missing); basal ganglia: 96.2500% (minimum 99%, Missing); cerebral cortex: 98.7179% (minimum 99%, Missing); esophagus: 75.4902% (minimum 97%, Missing); hippocampal formation: 97.4684% (minimum 99%, Missing); hypothalamus: 84.6154% (minimum 99%, Missing); lung: 96.2500% (minimum 99%, Missing); midbrain: 84.6154% (minimum 99%, Missing); pituitary gland: 87.5000% (minimum 99%, Missing); spinal cord: 50.3268% (minimum 99%, Missing); thyroid gland: 84.6154% (minimum 95%, Missing)",0,80,unavailable,7.6,2.5,1.4,"spinal cord: 7.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000136327,NKX2-8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.103846,-0.215098,-0.486732
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,5,0.9,1,"choroid plexus: 5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136449,MYCBPAP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.5959% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.1366% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.9845% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.8328% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7500% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.6686% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9045% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9045% (minimum 99%, Baseline (adaptation disabled)); lung: 98.2893% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.7500% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4424% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.5959% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7500% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,5,0.9,1,"choroid plexus: 5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136449,MYCBPAP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0344237,0.0159594,-0.0633138
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.1366% (minimum 99%, Missing); choroid plexus: 92.6686% (minimum 99%, Missing); hippocampal formation: 98.9045% (minimum 99%, Missing); hypothalamus: 98.9045% (minimum 99%, Missing); pituitary gland: 98.7500% (minimum 99%, Missing); retina: 98.4424% (minimum 99%, Missing)",0,6,partial,5,0.9,1,"choroid plexus: 5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136449,MYCBPAP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0390454,0.0159594,-0.0633138
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,99.7,0.2,0.2,"pituitary gland: 99.7 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000136487,GH2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8827% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 55.4114% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,99.7,0.2,0.2,"pituitary gland: 99.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000136487,GH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0483884,0.0283884,-0.435886
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pituitary gland: 55.4114% (minimum 99%, Missing)",0,1,partial,99.7,0.2,0.2,"pituitary gland: 99.7 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000136487,GH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.435886
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,38.3,19.4,25.4,"smooth muscle: 38.3 nTPM (vital, limit 6); stomach: 19.4 nTPM (protected, limit 12); lung: 10.4 nTPM (vital, limit 6)",pituitary gland / cells in anterior : High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,ENSG00000136488,CSH1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0,2,partial,38.3,19.4,25.4,"smooth muscle: 38.3 nTPM (vital, limit 1); spleen: 25.4 nTPM (manageable, limit 5); stomach: 19.4 nTPM (protected, limit 2); lung: 10.4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,ENSG00000136488,CSH1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0473358,0.0279639,0.00598814
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0,2,partial,38.3,19.4,25.4,"smooth muscle: 38.3 nTPM (vital, limit 6); stomach: 19.4 nTPM (protected, limit 12); lung: 10.4 nTPM (vital, limit 6)",pituitary gland / cells in anterior : High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,ENSG00000136488,CSH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0499159,0.03,0.00997897
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,10,partial,2.7,1.3,3.6,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000136492,BRIP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.9184% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.9167% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.5135% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.9167% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.9167% (minimum 99%, Baseline (adaptation disabled)); colon: 87.0370% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.0370% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.3333% (minimum 97%, Baseline (adaptation disabled)); kidney: 97.9167% (minimum 99%, Baseline (adaptation disabled)); liver: 87.0370% (minimum 99%, Baseline (adaptation disabled)); lung: 94.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 82.4561% (minimum 97%, Baseline (adaptation disabled)); pancreas: 95.9184% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.0370% (minimum 97%, Baseline (adaptation disabled)); retina: 95.9184% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.1569% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.9167% (minimum 99%, Baseline (adaptation disabled)); skin: 87.0370% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.0370% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.9167% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.1569% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.1569% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.6265% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.9184% (minimum 97%, Baseline (adaptation disabled))",0,10,partial,2.7,1.3,3.6,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000136492,BRIP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.383735,-0.186667,-0.354865
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.9184% (minimum 99%, Missing); amygdala: 97.9167% (minimum 99%, Missing); basal ganglia: 94.0000% (minimum 99%, Missing); bone marrow: 63.5135% (minimum 99%, Missing); cerebral cortex: 97.9167% (minimum 99%, Missing); choroid plexus: 97.9167% (minimum 99%, Missing); colon: 87.0370% (minimum 97%, Missing); duodenum: 87.0370% (minimum 99%, Missing); esophagus: 78.3333% (minimum 97%, Missing); kidney: 97.9167% (minimum 99%, Missing); liver: 87.0370% (minimum 99%, Missing); lung: 94.0000% (minimum 99%, Missing); lymph node: 82.4561% (minimum 97%, Missing); pancreas: 95.9184% (minimum 99%, Missing); rectum: 87.0370% (minimum 97%, Missing); retina: 95.9184% (minimum 99%, Missing); salivary gland: 92.1569% (minimum 97%, Missing); skeletal muscle: 97.9167% (minimum 99%, Missing); skin: 87.0370% (minimum 95%, Missing); small intestine: 87.0370% (minimum 99%, Missing); smooth muscle: 97.9167% (minimum 98%, Approved); spleen: 92.1569% (minimum 95%, Missing); stomach: 92.1569% (minimum 97%, Missing); thymus: 56.6265% (minimum 95%, Missing); urinary bladder: 95.9184% (minimum 97%, Missing)",0,10,partial,2.7,1.3,3.6,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000136492,BRIP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.383735,-0.186667,-0.354865
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,23,20.6,11.5,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 2); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 2); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 2); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 2); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 2); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); midbrain: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); hypothalamus: 5.3 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000136603,SKIL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 53.5714% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.7705% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.1925% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 36.9863% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.2353% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.7849% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.0347% (minimum 99%, Baseline (adaptation disabled)); colon: 57.2034% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.1859% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.2679% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 53.7849% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.1925% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.8085% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.6923% (minimum 99%, Baseline (adaptation disabled)); liver: 47.2028% (minimum 99%, Baseline (adaptation disabled)); lung: 46.3918% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.0526% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.2105% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.0526% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.7851% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.9520% (minimum 97%, Baseline (adaptation disabled)); retina: 59.2105% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.2174% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.7851% (minimum 99%, Baseline (adaptation disabled)); skin: 70.3125% (minimum 95%, Baseline (adaptation disabled)); small intestine: 49.4505% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.2034% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.1818% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.8537% (minimum 95%, Baseline (adaptation disabled)); stomach: 46.5517% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.1020% (minimum 95%, Baseline (adaptation disabled)); tongue: 39.5894% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 48.9130% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,23,20.6,11.5,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 2); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 2); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 2); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 2); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 2); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); midbrain: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); hypothalamus: 5.3 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000136603,SKIL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.41,-0.574106,-0.620137
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0000% (minimum 95%, Missing); adrenal gland: 53.5714% (minimum 99%, Missing); amygdala: 73.7705% (minimum 99%, Missing); basal ganglia: 72.1925% (minimum 99%, Missing); bone marrow: 36.9863% (minimum 99%, Missing); cerebellum: 88.2353% (minimum 99%, Uncertain); cerebral cortex: 53.7849% (minimum 99%, Missing); choroid plexus: 78.0347% (minimum 99%, Missing); colon: 57.2034% (minimum 97%, Missing); duodenum: 50.1859% (minimum 99%, Missing); esophagus: 60.2679% (minimum 97%, Missing); heart muscle: 53.7849% (minimum 99%, Uncertain); hippocampal formation: 72.1925% (minimum 99%, Missing); hypothalamus: 71.8085% (minimum 99%, Missing); kidney: 57.6923% (minimum 99%, Missing); liver: 47.2028% (minimum 99%, Missing); lung: 46.3918% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Uncertain); midbrain: 71.0526% (minimum 99%, Missing); pancreas: 59.2105% (minimum 99%, Uncertain); parathyroid gland: 71.0526% (minimum 97%, Missing); pituitary gland: 55.7851% (minimum 99%, Missing); rectum: 58.9520% (minimum 97%, Missing); retina: 59.2105% (minimum 99%, Missing); salivary gland: 65.2174% (minimum 97%, Missing); skeletal muscle: 55.7851% (minimum 99%, Missing); skin: 70.3125% (minimum 95%, Missing); small intestine: 49.4505% (minimum 99%, Missing); smooth muscle: 57.2034% (minimum 99%, Uncertain); spinal cord: 68.1818% (minimum 99%, Missing); spleen: 65.8537% (minimum 95%, Uncertain); stomach: 46.5517% (minimum 97%, Missing); thymus: 60.0000% (minimum 95%, Missing); thyroid gland: 55.1020% (minimum 95%, Missing); tongue: 39.5894% (minimum 97%, Missing); urinary bladder: 48.9130% (minimum 97%, Missing)",0,1,partial,23,20.6,11.5,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 2); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 2); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 2); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 2); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 2); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); spleen: 7 nTPM (manageable, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); midbrain: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); hypothalamus: 5.3 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000136603,SKIL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.41,-0.574106,-0.620137
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,13,partial,36.6,17.5,24.1,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 6); pituitary gland: 29.8 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); bone marrow: 22.3 nTPM (vital, limit 6); lymph node: 17.5 nTPM (protected, limit 12); urinary bladder: 16.1 nTPM (protected, limit 12); liver: 16 nTPM (vital, limit 6); colon: 14.6 nTPM (protected, limit 2); smooth muscle: 13.8 nTPM (vital, limit 6); kidney: 13.7 nTPM (vital, limit 6); lung: 13.6 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 12); small intestine: 13 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 6); pancreas: 11.5 nTPM (vital, limit 6); cerebral cortex: 11.1 nTPM (vital, limit 6); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 2); adrenal gland: 9.7 nTPM (vital, limit 6); hippocampal formation: 9.6 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 6); duodenum: 7.4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),85,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136811,ODF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.9535% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.5047% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2590% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.2628% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.0619% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.5291% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.4005% (minimum 99%, Baseline (adaptation disabled)); colon: 95.4841% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.6590% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.4085% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.1083% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.9840% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.5895% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.7506% (minimum 99%, Baseline (adaptation disabled)); liver: 95.0724% (minimum 99%, Baseline (adaptation disabled)); lung: 95.7803% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.6352% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.2896% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.4085% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.1965% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.8623% (minimum 97%, Baseline (adaptation disabled)); retina: 97.0450% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.3183% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.5972% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.9590% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.7209% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.0450% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.7223% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.9590% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.7584% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.0431% (minimum 97%, Baseline (adaptation disabled))",0,13,partial,36.6,17.5,24.1,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pituitary gland: 29.8 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); bone marrow: 22.3 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 2); spleen: 17.2 nTPM (manageable, limit 5); urinary bladder: 16.1 nTPM (protected, limit 2); liver: 16 nTPM (vital, limit 1); colon: 14.6 nTPM (protected, limit 2); smooth muscle: 13.8 nTPM (vital, limit 1); kidney: 13.7 nTPM (vital, limit 1); lung: 13.6 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); skin: 12.7 nTPM (manageable, limit 5); heart muscle: 12.5 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 11.8 nTPM (protected, limit 2); esophagus: 11.5 nTPM (protected, limit 2); pancreas: 11.5 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 2); adrenal gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),85,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136811,ODF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0224159,-0.0236481,-0.0959948
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.5047% (minimum 99%, Missing); basal ganglia: 97.2590% (minimum 99%, Missing); bone marrow: 93.2628% (minimum 95%, Enhanced); cerebellum: 91.0619% (minimum 95%, Enhanced); choroid plexus: 89.4005% (minimum 99%, Missing); colon: 95.4841% (minimum 97%, Missing); duodenum: 97.6590% (minimum 99%, Missing); hippocampal formation: 96.9840% (minimum 99%, Missing); hypothalamus: 96.5895% (minimum 99%, Missing); lung: 95.7803% (minimum 99%, Missing); midbrain: 97.2896% (minimum 99%, Missing); pituitary gland: 91.1965% (minimum 99%, Missing); rectum: 96.8623% (minimum 97%, Missing); retina: 97.0450% (minimum 99%, Missing); small intestine: 95.9590% (minimum 99%, Missing); spinal cord: 97.0450% (minimum 99%, Missing); thymus: 92.7584% (minimum 95%, Missing)",0,13,partial,36.6,17.5,24.1,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 6); pituitary gland: 29.8 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); bone marrow: 22.3 nTPM (vital, limit 6); lymph node: 17.5 nTPM (protected, limit 12); urinary bladder: 16.1 nTPM (protected, limit 12); liver: 16 nTPM (vital, limit 6); colon: 14.6 nTPM (protected, limit 2); smooth muscle: 13.8 nTPM (vital, limit 6); kidney: 13.7 nTPM (vital, limit 6); lung: 13.6 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 12); small intestine: 13 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 6); pancreas: 11.5 nTPM (vital, limit 6); cerebral cortex: 11.1 nTPM (vital, limit 6); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 2); adrenal gland: 9.7 nTPM (vital, limit 6); hippocampal formation: 9.6 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 6); duodenum: 7.4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),85,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136811,ODF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0224159,-0.0151593,-0.0959948
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.1,2.8,2.8,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136866,ZFP37,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 81.2500% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.2683% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.3133% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.5814% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.0149% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.7477% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.5263% (minimum 99%, Baseline (adaptation disabled)); colon: 80.2469% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.2778% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.4156% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.2500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.3133% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.5814% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.7126% (minimum 99%, Baseline (adaptation disabled)); liver: 91.5493% (minimum 99%, Baseline (adaptation disabled)); lung: 84.4156% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.4156% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.2683% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.4156% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.8925% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.7255% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 51.5873% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.0411% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 84.4156% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.0337% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.0337% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.4706% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.4156% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.5263% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 69.8925% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.3810% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 79.2683% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.1,2.8,2.8,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136866,ZFP37,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.251075,-0.271075,-0.474127
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 81.2500% (minimum 95%, Missing); adrenal gland: 79.2683% (minimum 99%, Missing); amygdala: 78.3133% (minimum 99%, Missing); basal ganglia: 75.5814% (minimum 99%, Missing); bone marrow: 97.0149% (minimum 99%, Missing); cerebellum: 60.7477% (minimum 99%, Missing); cerebral cortex: 65.0000% (minimum 99%, Missing); choroid plexus: 85.5263% (minimum 99%, Missing); colon: 80.2469% (minimum 97%, Missing); duodenum: 90.2778% (minimum 99%, Missing); esophagus: 84.4156% (minimum 97%, Missing); heart muscle: 81.2500% (minimum 99%, Missing); hippocampal formation: 78.3133% (minimum 99%, Missing); hypothalamus: 75.5814% (minimum 99%, Missing); kidney: 74.7126% (minimum 99%, Missing); liver: 91.5493% (minimum 99%, Missing); lung: 84.4156% (minimum 99%, Missing); lymph node: 84.4156% (minimum 97%, Missing); midbrain: 79.2683% (minimum 99%, Missing); pancreas: 84.4156% (minimum 99%, Missing); parathyroid gland: 69.8925% (minimum 97%, Missing); pituitary gland: 63.7255% (minimum 99%, Missing); rectum: 86.6667% (minimum 97%, Missing); retina: 51.5873% (minimum 99%, Missing); salivary gland: 89.0411% (minimum 97%, Missing); skeletal muscle: 83.3333% (minimum 99%, Missing); skin: 84.4156% (minimum 95%, Missing); small intestine: 86.6667% (minimum 99%, Missing); smooth muscle: 73.0337% (minimum 99%, Missing); spinal cord: 73.0337% (minimum 99%, Missing); spleen: 76.4706% (minimum 95%, Missing); stomach: 84.4156% (minimum 97%, Missing); thymus: 85.5263% (minimum 95%, Missing); thyroid gland: 69.8925% (minimum 95%, Missing); tongue: 77.3810% (minimum 97%, Missing); urinary bladder: 79.2683% (minimum 97%, Missing)",0,80,unavailable,6.1,2.8,2.8,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136866,ZFP37,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.251075,-0.271075,-0.474127
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,243.6,1.5,12.5,"bone marrow: 243.6 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136929,HEMGN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 16.7749% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9919% (minimum 99%, Baseline (adaptation disabled)); lung: 98.2000% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7928% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.0613% (minimum 95%, Baseline (adaptation disabled)); thymus: 79.7078% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,243.6,1.5,12.5,"bone marrow: 243.6 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136929,HEMGN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,-0.152922,0.000355731,-0.822251
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 16.7749% (minimum 99%, Missing); retina: 98.7928% (minimum 99%, Missing); thymus: 79.7078% (minimum 95%, Missing)",0,2,partial,243.6,1.5,12.5,"bone marrow: 243.6 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000136929,HEMGN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,-0.152922,0.0279675,-0.822251
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.6,18,2,"salivary gland: 18 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000136944,LMX1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.9565% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 97.5610% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.5610% (minimum 99%, Baseline (adaptation disabled)); colon: 88.8889% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.7966% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5610% (minimum 99%, Baseline (adaptation disabled)); midbrain: 52.6316% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.2381% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.2381% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 18.1818% (minimum 97%, Baseline (adaptation disabled)); skin: 66.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.5610% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.4717% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 90.9091% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.6,18,2,"salivary gland: 18 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000136944,LMX1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.283333,-0.788182,-0.463684
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.9565% (minimum 95%, Missing); bone marrow: 97.5610% (minimum 99%, Missing); choroid plexus: 97.5610% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); heart muscle: 67.7966% (minimum 99%, Missing); hypothalamus: 90.9091% (minimum 99%, Missing); kidney: 53.3333% (minimum 99%, Missing); lung: 97.5610% (minimum 99%, Missing); midbrain: 52.6316% (minimum 99%, Missing); pancreas: 95.2381% (minimum 99%, Missing); parathyroid gland: 80.0000% (minimum 97%, Missing); pituitary gland: 95.2381% (minimum 99%, Missing); salivary gland: 18.1818% (minimum 97%, Missing); skin: 66.6667% (minimum 95%, Missing); small intestine: 97.5610% (minimum 99%, Missing); spinal cord: 75.4717% (minimum 99%, Missing); thyroid gland: 90.9091% (minimum 95%, Missing)",0,80,unavailable,3.6,18,2,"salivary gland: 18 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000136944,LMX1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.283333,-0.788182,-0.463684
True,compatible,,True,True,False,,0,2,partial,0.3,0,0.2,,,54,not_established,not_triggered,,,ENSG00000137090,DMRT1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.8636% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.3,0,0.2,,,54,not_established,not_triggered,,,ENSG00000137090,DMRT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0423954,0.03,-0.00136364
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.8636% (minimum 99%, Missing)",0,2,partial,0.3,0,0.2,,,54,not_established,not_triggered,,,ENSG00000137090,DMRT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.00136364
True,compatible,,True,True,False,,0,3,partial,0.4,0.4,2.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137225,CAPN11,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.6622% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6622% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.9933% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.6622% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.9933% (minimum 99%, Baseline (adaptation disabled)); thymus: 93.3544% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,0.4,0.4,2.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137225,CAPN11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0164557,0.0166221,-0.00337793
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 93.3544% (minimum 95%, Missing)",0,3,partial,0.4,0.4,2.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137225,CAPN11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0164557,0.0266216,0.00662162
True,compatible,,True,True,False,,0,5,partial,3.4,0.2,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000137270,GCM1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.4848% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.7500% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4848% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 85.1528% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,3.4,0.2,0.4,"skeletal muscle: 3.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000137270,GCM1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0298995,0.0198477,-0.138472
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 93.7500% (minimum 95%, Enhanced); retina: 98.4848% (minimum 99%, Missing); skeletal muscle: 85.1528% (minimum 95%, Enhanced)",0,5,partial,3.4,0.2,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000137270,GCM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.0984716
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.3,1.5,1.3,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137434,C6orf52,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.0070% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.0795% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.5682% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.6061% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.7941% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.4762% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.1205% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.1772% (minimum 99%, Baseline (adaptation disabled)); colon: 95.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.8649% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.6835% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.6835% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.2353% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.5682% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.5682% (minimum 99%, Baseline (adaptation disabled)); liver: 95.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 93.0070% (minimum 99%, Baseline (adaptation disabled)); midbrain: 77.3256% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.8065% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 95.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.3768% (minimum 99%, Baseline (adaptation disabled)); skin: 91.0959% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.7941% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.1667% (minimum 99%, Baseline (adaptation disabled)); stomach: 89.8649% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.6620% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.6835% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.3,1.5,1.3,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137434,C6orf52,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0390411,-0.0713514,-0.234318
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.0070% (minimum 95%, Missing); adrenal gland: 88.0795% (minimum 99%, Missing); amygdala: 75.5682% (minimum 99%, Missing); basal ganglia: 80.6061% (minimum 99%, Missing); bone marrow: 97.7941% (minimum 99%, Missing); cerebellum: 90.4762% (minimum 99%, Missing); cerebral cortex: 80.1205% (minimum 99%, Missing); choroid plexus: 84.1772% (minimum 99%, Missing); colon: 95.0000% (minimum 97%, Missing); duodenum: 89.8649% (minimum 99%, Missing); esophagus: 95.6835% (minimum 97%, Missing); heart muscle: 95.6835% (minimum 99%, Missing); hippocampal formation: 78.2353% (minimum 99%, Missing); hypothalamus: 75.5682% (minimum 99%, Missing); kidney: 75.5682% (minimum 99%, Missing); liver: 95.0000% (minimum 99%, Missing); lung: 93.0070% (minimum 99%, Missing); midbrain: 77.3256% (minimum 99%, Missing); pancreas: 85.8065% (minimum 99%, Missing); pituitary gland: 87.5000% (minimum 99%, Missing); retina: 95.0000% (minimum 99%, Missing); salivary gland: 95.0000% (minimum 97%, Missing); skeletal muscle: 96.3768% (minimum 99%, Missing); skin: 91.0959% (minimum 95%, Missing); small intestine: 95.0000% (minimum 99%, Missing); smooth muscle: 97.7941% (minimum 99%, Missing); spinal cord: 79.1667% (minimum 99%, Missing); stomach: 89.8649% (minimum 97%, Missing); thyroid gland: 93.6620% (minimum 95%, Missing); urinary bladder: 95.6835% (minimum 97%, Missing)",0,80,unavailable,4.3,1.5,1.3,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137434,C6orf52,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0390411,-0.0713514,-0.234318
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,5.9,0.6,0.1,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / melanocytes,ENSG00000137473,TTC29,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.7270% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0337% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.2061% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.1716% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.8962% (minimum 99%, Baseline (adaptation disabled)); lung: 97.3501% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,5.9,0.6,0.1,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / melanocytes,ENSG00000137473,TTC29,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0485694,0.0214773,-0.0679392
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.7270% (minimum 99%, Missing); basal ganglia: 98.0337% (minimum 99%, Missing); choroid plexus: 92.2061% (minimum 99%, Missing); hippocampal formation: 98.1716% (minimum 99%, Missing); hypothalamus: 97.8962% (minimum 99%, Missing); lung: 97.3501% (minimum 99%, Uncertain)",0,0,routine_complete,5.9,0.6,0.1,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / melanocytes,ENSG00000137473,TTC29,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0485694,0.0214773,-0.0679392
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000137674,MMP20,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"kidney: 85.7143% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000137674,MMP20,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.132857
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"kidney: 85.7143% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000137674,MMP20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.132857
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,23.6,2.9,3.5,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137691,CFAP300,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.8495% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.8773% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.9103% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.9938% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9865% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.3816% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 55.3875% (minimum 99%, Baseline (adaptation disabled)); colon: 95.7516% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.3422% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.5161% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.0656% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.8495% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.6024% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.8220% (minimum 99%, Baseline (adaptation disabled)); lung: 91.2773% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.1299% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.3422% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.8495% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.2530% (minimum 99%, Baseline (adaptation disabled)); retina: 95.7516% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.3422% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.2773% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.4397% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.2122% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 89.3293% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 90.9938% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,23.6,2.9,3.5,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); basal ganglia: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); amygdala: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137691,CFAP300,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0567073,-0.0600621,-0.436125
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 89.8773% (minimum 95%, Enhanced); amygdala: 93.9103% (minimum 99%, Missing); basal ganglia: 90.9938% (minimum 99%, Missing); choroid plexus: 55.3875% (minimum 99%, Missing); hippocampal formation: 91.8495% (minimum 99%, Missing); hypothalamus: 89.6024% (minimum 99%, Missing); kidney: 94.8220% (minimum 95%, Enhanced); lung: 91.2773% (minimum 95%, Enhanced); midbrain: 95.1299% (minimum 99%, Missing); pituitary gland: 88.2530% (minimum 99%, Missing); retina: 95.7516% (minimum 99%, Missing); smooth muscle: 91.2773% (minimum 95%, Enhanced); spinal cord: 95.4397% (minimum 99%, Missing)",0,3,partial,23.6,2.9,3.5,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137691,CFAP300,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0299331,0.03,-0.436125
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.3,0,0.1,"choroid plexus: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000137707,BTG4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 83.6502% (minimum 99%, Baseline (adaptation disabled)); lung: 98.2143% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,4.3,0,0.1,"choroid plexus: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000137707,BTG4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0454751,0.03,-0.153498
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 83.6502% (minimum 99%, Missing); lung: 98.2143% (minimum 99%, Missing)",0,80,unavailable,4.3,0,0.1,"choroid plexus: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000137707,BTG4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0454751,0.03,-0.153498
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,20.2,18.9,24.6,"thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 2); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (manageable, limit 10); smooth muscle: 13.4 nTPM (vital, limit 2); spleen: 12.9 nTPM (manageable, limit 5); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 2); urinary bladder: 11.8 nTPM (protected, limit 2); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.7 nTPM (protected, limit 2); colon: 10.5 nTPM (protected, limit 2); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 2); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 2); cerebellum: 9 nTPM (vital, limit 2); salivary gland: 8.9 nTPM (protected, limit 2); skin: 7.9 nTPM (manageable, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000137770,CTDSPL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.1031% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.9130% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.0759% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.0759% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 50.2463% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 69.3878% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.4407% (minimum 99%, Baseline (adaptation disabled)); colon: 66.0194% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.7741% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.7692% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.9189% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.8085% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.2338% (minimum 99%, Baseline (adaptation disabled)); liver: 67.1053% (minimum 99%, Baseline (adaptation disabled)); lung: 66.8852% (minimum 99%, Baseline (adaptation disabled)); lymph node: 51.9084% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.9310% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.5570% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.5949% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.9506% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.1757% (minimum 97%, Baseline (adaptation disabled)); retina: 58.1197% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.6246% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 79.6875% (minimum 99%, Baseline (adaptation disabled)); skin: 72.0848% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.1951% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.3550% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.6473% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.2613% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.2274% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.2857% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.1525% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.3540% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,20.2,18.9,24.6,"thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 2); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (manageable, limit 5); smooth muscle: 13.4 nTPM (vital, limit 1); spleen: 12.9 nTPM (manageable, limit 5); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 2); urinary bladder: 11.8 nTPM (protected, limit 2); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.7 nTPM (protected, limit 2); colon: 10.5 nTPM (protected, limit 2); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 2); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 2); cerebellum: 9 nTPM (vital, limit 1); salivary gland: 8.9 nTPM (protected, limit 2); adipose tissue: 8.7 nTPM (manageable, limit 5); skin: 7.9 nTPM (manageable, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000137770,CTDSPL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.496667,-0.450916,-0.487537
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.1031% (minimum 90%, Approved); adrenal gland: 73.9130% (minimum 99%, Missing); amygdala: 86.0759% (minimum 99%, Missing); basal ganglia: 86.0759% (minimum 99%, Missing); bone marrow: 50.2463% (minimum 99%, Missing); cerebellum: 69.3878% (minimum 98%, Approved); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 86.4407% (minimum 99%, Missing); colon: 66.0194% (minimum 97%, Missing); duodenum: 67.7741% (minimum 99%, Missing); esophagus: 62.7692% (minimum 97%, Missing); heart muscle: 68.9189% (minimum 99%, Missing); hippocampal formation: 85.7143% (minimum 99%, Missing); hypothalamus: 86.8085% (minimum 99%, Missing); kidney: 66.2338% (minimum 99%, Missing); liver: 67.1053% (minimum 99%, Missing); lung: 66.8852% (minimum 99%, Missing); lymph node: 51.9084% (minimum 97%, Missing); midbrain: 87.9310% (minimum 99%, Missing); pancreas: 64.5570% (minimum 99%, Missing); parathyroid gland: 65.5949% (minimum 97%, Missing); pituitary gland: 83.9506% (minimum 99%, Missing); rectum: 65.1757% (minimum 97%, Missing); retina: 58.1197% (minimum 99%, Missing); salivary gland: 69.6246% (minimum 97%, Missing); skeletal muscle: 79.6875% (minimum 99%, Missing); skin: 72.0848% (minimum 95%, Missing); small intestine: 62.1951% (minimum 99%, Missing); smooth muscle: 60.3550% (minimum 98%, Approved); spinal cord: 84.6473% (minimum 99%, Missing); spleen: 61.2613% (minimum 95%, Missing); stomach: 68.2274% (minimum 97%, Missing); thymus: 45.3333% (minimum 95%, Missing); thyroid gland: 58.2857% (minimum 90%, Approved); tongue: 69.1525% (minimum 97%, Missing); urinary bladder: 63.3540% (minimum 97%, Missing)",0,5,partial,20.2,18.9,24.6,"thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 2); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (manageable, limit 10); smooth muscle: 13.4 nTPM (vital, limit 2); spleen: 12.9 nTPM (manageable, limit 5); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 2); urinary bladder: 11.8 nTPM (protected, limit 2); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.7 nTPM (protected, limit 2); colon: 10.5 nTPM (protected, limit 2); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 2); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 2); cerebellum: 9 nTPM (vital, limit 2); salivary gland: 8.9 nTPM (protected, limit 2); skin: 7.9 nTPM (manageable, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000137770,CTDSPL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.496667,-0.450916,-0.487537
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,5.1,3.5,7.2,"thymus: 7.2 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000137812,KNL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 76.2791% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.6190% (minimum 99%, Baseline (adaptation disabled)); colon: 93.1818% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.6201% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.7977% (minimum 97%, Baseline (adaptation disabled)); kidney: 97.0414% (minimum 99%, Baseline (adaptation disabled)); liver: 95.9064% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6190% (minimum 99%, Baseline (adaptation disabled)); lymph node: 82.4121% (minimum 97%, Baseline (adaptation disabled)); rectum: 92.6554% (minimum 97%, Baseline (adaptation disabled)); retina: 98.7952% (minimum 99%, Baseline (adaptation disabled)); small intestine: 91.1111% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.4706% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.3488% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.4915% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,5.1,3.5,7.2,"thymus: 7.2 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000137812,KNL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.255085,-0.145879,-0.227209
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 76.2791% (minimum 99%, Missing); colon: 93.1818% (minimum 97%, Missing); duodenum: 91.6201% (minimum 99%, Missing); esophagus: 94.7977% (minimum 97%, Missing); lymph node: 82.4121% (minimum 97%, Missing); rectum: 92.6554% (minimum 97%, Missing); retina: 98.7952% (minimum 99%, Missing); small intestine: 91.1111% (minimum 99%, Missing); thymus: 69.4915% (minimum 95%, Missing)",0,2,partial,5.1,3.5,7.2,"thymus: 7.2 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000137812,KNL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.255085,-0.145879,-0.227209
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,31.8,24.9,27.3,"cerebral cortex: 31.8 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 24.9 nTPM (protected, limit 2); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 2); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 2); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 2); parathyroid gland: 7.7 nTPM (protected, limit 4); thyroid gland: 7.2 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 2); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); thyroid gland / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000137843,PAK6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.2540% (minimum 99%, Baseline (adaptation disabled)); amygdala: 43.5443% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 43.1078% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.0276% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 46.2366% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 35.1020% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.2051% (minimum 99%, Baseline (adaptation disabled)); colon: 93.4783% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.4731% (minimum 99%, Baseline (adaptation disabled)); esophagus: 40.8551% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.2540% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 49.4253% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.9842% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.8991% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2857% (minimum 99%, Baseline (adaptation disabled)); lung: 87.3096% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.0276% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.9024% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.8000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.0763% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.3103% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.5055% (minimum 97%, Baseline (adaptation disabled)); retina: 95.5556% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.1379% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 38.6517% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.4731% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.2857% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.0053% (minimum 99%, Baseline (adaptation disabled)); stomach: 81.9048% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 70.4918% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.4783% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.4951% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,31.8,24.9,27.3,"cerebral cortex: 31.8 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 24.9 nTPM (protected, limit 2); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 1); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); thyroid gland: 7.2 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 2); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); thyroid gland / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000137843,PAK6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.563483,-0.561449,-0.63898
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.2540% (minimum 98%, Approved); amygdala: 43.5443% (minimum 99%, Missing); basal ganglia: 43.1078% (minimum 99%, Missing); bone marrow: 95.0276% (minimum 98%, Approved); cerebellum: 46.2366% (minimum 98%, Approved); cerebral cortex: 35.1020% (minimum 99%, Missing); choroid plexus: 88.2051% (minimum 99%, Missing); colon: 93.4783% (minimum 95%, Approved); duodenum: 92.4731% (minimum 98%, Approved); esophagus: 40.8551% (minimum 97%, Missing); heart muscle: 68.2540% (minimum 99%, Missing); hippocampal formation: 49.4253% (minimum 99%, Missing); hypothalamus: 67.9842% (minimum 99%, Missing); kidney: 78.8991% (minimum 99%, Missing); lung: 87.3096% (minimum 98%, Approved); midbrain: 83.9024% (minimum 99%, Missing); pancreas: 68.8000% (minimum 98%, Approved); parathyroid gland: 69.0763% (minimum 95%, Approved); pituitary gland: 59.3103% (minimum 99%, Missing); rectum: 94.5055% (minimum 95%, Approved); retina: 95.5556% (minimum 99%, Missing); salivary gland: 74.1379% (minimum 95%, Approved); skeletal muscle: 80.0000% (minimum 98%, Approved); skin: 38.6517% (minimum 95%, Missing); small intestine: 92.4731% (minimum 98%, Approved); spinal cord: 91.0053% (minimum 99%, Missing); stomach: 81.9048% (minimum 95%, Approved); thyroid gland: 70.4918% (minimum 95%, Missing); tongue: 93.4783% (minimum 97%, Missing); urinary bladder: 83.4951% (minimum 95%, Approved)",0,1,partial,31.8,24.9,27.3,"cerebral cortex: 31.8 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 24.9 nTPM (protected, limit 2); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 2); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 2); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 2); parathyroid gland: 7.7 nTPM (protected, limit 4); thyroid gland: 7.2 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 2); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); thyroid gland / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000137843,PAK6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.563483,-0.561449,-0.63898
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,8.2,3.3,8,"adrenal gland: 8.2 nTPM (vital, limit 6)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000137869,CYP19A1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7743% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.6286% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.9327% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,8.2,3.3,8,"adrenal gland: 8.2 nTPM (vital, limit 1); adipose tissue: 8 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 2); smooth muscle: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000137869,CYP19A1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.0122568,0.0033441,-0.0537141
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.6286% (minimum 95%, Enhanced)",0,1,partial,8.2,3.3,8,"adrenal gland: 8.2 nTPM (vital, limit 6)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000137869,CYP19A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.048343,0.0275166,-0.0137141
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,6,partial,2.6,0.4,0.4,"bone marrow: 2.6 nTPM (vital, limit 2)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000137948,BRDT,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.0031% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,2.6,0.4,0.4,"bone marrow: 2.6 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000137948,BRDT,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.046875,0.026875,-0.00996928
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,6,partial,2.6,0.4,0.4,"bone marrow: 2.6 nTPM (vital, limit 2)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000137948,BRDT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0484351,0.0292169,3.0722e-05
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.2,6.4,10.4,"skin: 10.4 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137968,SLC44A5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7368% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.5246% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.9730% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.7143% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.4286% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.4286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.7907% (minimum 99%, Baseline (adaptation disabled)); colon: 72.9730% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.8182% (minimum 99%, Baseline (adaptation disabled)); esophagus: 45.7627% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.2308% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.1299% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.2308% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.9726% (minimum 99%, Baseline (adaptation disabled)); liver: 84.3750% (minimum 99%, Baseline (adaptation disabled)); lung: 90.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.5254% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.9726% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.0563% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.5294% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 69.2308% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.4118% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.2609% (minimum 99%, Baseline (adaptation disabled)); skin: 34.1772% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.5970% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.4286% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.7143% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.5246% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.4118% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.3544% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.5246% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.2609% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.1429% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.2,6.4,10.4,"skin: 10.4 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137968,SLC44A5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.608228,-0.512373,-0.362093
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7368% (minimum 95%, Missing); adrenal gland: 88.5246% (minimum 99%, Missing); amygdala: 72.9730% (minimum 99%, Missing); basal ganglia: 85.7143% (minimum 99%, Missing); bone marrow: 96.4286% (minimum 99%, Missing); cerebellum: 96.4286% (minimum 99%, Missing); cerebral cortex: 62.7907% (minimum 99%, Missing); colon: 72.9730% (minimum 97%, Missing); duodenum: 81.8182% (minimum 99%, Missing); esophagus: 45.7627% (minimum 97%, Missing); heart muscle: 69.2308% (minimum 99%, Missing); hippocampal formation: 70.1299% (minimum 99%, Missing); hypothalamus: 69.2308% (minimum 99%, Missing); kidney: 73.9726% (minimum 99%, Missing); liver: 84.3750% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); lymph node: 91.5254% (minimum 97%, Missing); midbrain: 73.9726% (minimum 99%, Missing); pancreas: 76.0563% (minimum 99%, Missing); parathyroid gland: 60.0000% (minimum 97%, Missing); pituitary gland: 63.5294% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 69.2308% (minimum 99%, Missing); salivary gland: 79.4118% (minimum 97%, Missing); skeletal muscle: 78.2609% (minimum 99%, Missing); skin: 34.1772% (minimum 95%, Missing); small intestine: 80.5970% (minimum 99%, Missing); smooth muscle: 96.4286% (minimum 99%, Missing); spinal cord: 85.7143% (minimum 99%, Missing); spleen: 88.5246% (minimum 95%, Missing); stomach: 79.4118% (minimum 97%, Missing); thymus: 68.3544% (minimum 95%, Missing); thyroid gland: 88.5246% (minimum 95%, Missing); tongue: 78.2609% (minimum 97%, Missing); urinary bladder: 77.1429% (minimum 97%, Missing)",0,80,unavailable,3.2,6.4,10.4,"skin: 10.4 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000137968,SLC44A5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.608228,-0.512373,-0.362093
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.3,165.3,0.5,"salivary gland: 165.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000137976,DNASE2B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.8571% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.4848% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.0149% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.4848% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.5882% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.4848% (minimum 99%, Baseline (adaptation disabled)); colon: 94.2029% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 95.5882% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.8571% (minimum 99%, Baseline (adaptation disabled)); liver: 95.5882% (minimum 99%, Baseline (adaptation disabled)); lung: 73.8636% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.2778% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.5882% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.2778% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.5882% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.8571% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 3.7835% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.2500% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.4848% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.4156% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.2029% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.2778% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.3,165.3,0.5,"salivary gland: 165.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000137976,DNASE2B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0214286,-0.932165,-0.251364
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.8571% (minimum 95%, Missing); adrenal gland: 98.4848% (minimum 99%, Missing); amygdala: 97.0149% (minimum 99%, Missing); basal ganglia: 86.6667% (minimum 99%, Missing); cerebellum: 98.4848% (minimum 99%, Missing); cerebral cortex: 95.5882% (minimum 99%, Missing); choroid plexus: 98.4848% (minimum 99%, Missing); colon: 94.2029% (minimum 97%, Missing); hippocampal formation: 95.5882% (minimum 99%, Missing); hypothalamus: 92.8571% (minimum 99%, Missing); liver: 95.5882% (minimum 99%, Missing); lung: 73.8636% (minimum 99%, Missing); lymph node: 90.2778% (minimum 97%, Missing); midbrain: 95.5882% (minimum 99%, Missing); pancreas: 90.2778% (minimum 99%, Missing); pituitary gland: 95.5882% (minimum 99%, Missing); rectum: 92.8571% (minimum 97%, Missing); salivary gland: 3.7835% (minimum 97%, Missing); skeletal muscle: 81.2500% (minimum 99%, Missing); small intestine: 98.4848% (minimum 99%, Missing); spinal cord: 84.4156% (minimum 99%, Missing); spleen: 94.2029% (minimum 95%, Missing); stomach: 90.2778% (minimum 97%, Missing)",0,80,unavailable,2.3,165.3,0.5,"salivary gland: 165.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000137976,DNASE2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0214286,-0.932165,-0.251364
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.3,0.2,0,,,0,not_established,not_triggered,,,ENSG00000138068,SULT6B1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 85.7143% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.2,0,,,0,not_established,not_triggered,,,ENSG00000138068,SULT6B1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,-0.07,-0.132857
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 85.7143% (minimum 99%, Missing); esophagus: 90.0000% (minimum 97%, Missing)",0,80,unavailable,0.3,0.2,0,,,0,not_established,not_triggered,,,ENSG00000138068,SULT6B1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,-0.07,-0.132857
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.1,4.8,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); hippocampal formation: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138092,CENPO,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3636% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.8537% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.8537% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 47.0930% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 66.9421% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.7907% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.8846% (minimum 99%, Baseline (adaptation disabled)); colon: 71.6814% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.3214% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.8000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.3226% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.9421% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.3119% (minimum 99%, Baseline (adaptation disabled)); liver: 76.4151% (minimum 99%, Baseline (adaptation disabled)); lung: 69.8276% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.7907% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.9421% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.3750% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.8276% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.2308% (minimum 97%, Baseline (adaptation disabled)); retina: 85.2632% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.4151% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 73.6364% (minimum 99%, Baseline (adaptation disabled)); skin: 68.6441% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.0672% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 79.4118% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.6441% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.8537% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.7009% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.1875% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.0526% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.1429% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.1,4.8,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); hippocampal formation: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138092,CENPO,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.528125,-0.342093,-0.51907
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3636% (minimum 95%, Missing); adrenal gland: 67.5000% (minimum 99%, Missing); amygdala: 65.8537% (minimum 99%, Missing); basal ganglia: 65.8537% (minimum 99%, Missing); bone marrow: 47.0930% (minimum 99%, Missing); cerebellum: 66.9421% (minimum 99%, Missing); cerebral cortex: 62.7907% (minimum 99%, Missing); choroid plexus: 77.8846% (minimum 99%, Missing); colon: 71.6814% (minimum 97%, Missing); duodenum: 72.3214% (minimum 99%, Missing); esophagus: 64.8000% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); hippocampal formation: 65.3226% (minimum 99%, Missing); hypothalamus: 66.9421% (minimum 99%, Missing); kidney: 74.3119% (minimum 99%, Missing); liver: 76.4151% (minimum 99%, Missing); lung: 69.8276% (minimum 99%, Missing); lymph node: 62.7907% (minimum 97%, Missing); midbrain: 66.9421% (minimum 99%, Missing); pancreas: 81.0000% (minimum 99%, Missing); parathyroid gland: 84.3750% (minimum 97%, Missing); pituitary gland: 69.8276% (minimum 99%, Missing); rectum: 69.2308% (minimum 97%, Missing); retina: 85.2632% (minimum 99%, Missing); salivary gland: 76.4151% (minimum 97%, Missing); skeletal muscle: 73.6364% (minimum 99%, Missing); skin: 68.6441% (minimum 95%, Missing); small intestine: 68.0672% (minimum 99%, Missing); smooth muscle: 79.4118% (minimum 99%, Missing); spinal cord: 68.6441% (minimum 99%, Missing); spleen: 65.8537% (minimum 95%, Missing); stomach: 75.7009% (minimum 97%, Missing); thymus: 42.1875% (minimum 95%, Missing); thyroid gland: 71.0526% (minimum 95%, Missing); tongue: 81.0000% (minimum 97%, Missing); urinary bladder: 77.1429% (minimum 97%, Missing)",0,80,unavailable,9.1,4.8,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); hippocampal formation: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); liver: 2.5 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138092,CENPO,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.528125,-0.342093,-0.51907
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,2088.7,5.8,1,"liver: 2088.7 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138115,CYP2C8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.8571% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.6429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.9032% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.1220% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.2500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.2414% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.9787% (minimum 99%, Baseline (adaptation disabled)); colon: 90.6977% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.5000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.5849% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.9375% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.5849% (minimum 99%, Baseline (adaptation disabled)); liver: 0.1864% (minimum 99%, Baseline (adaptation disabled)); lung: 90.6977% (minimum 99%, Baseline (adaptation disabled)); midbrain: 79.5918% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.9091% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.6364% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.5217% (minimum 99%, Baseline (adaptation disabled)); retina: 56.5217% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.1220% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.1220% (minimum 99%, Baseline (adaptation disabled)); small intestine: 78.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 79.5918% (minimum 95%, Baseline (adaptation disabled)); stomach: 40.2062% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 81.2500% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.1220% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,2088.7,5.8,1,"liver: 2088.7 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138115,CYP2C8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.154082,-0.567938,-0.988136
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.6429% (minimum 95%, Enhanced); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 62.9032% (minimum 99%, Missing); cerebellum: 81.2500% (minimum 95%, Enhanced); cerebral cortex: 67.2414% (minimum 95%, Enhanced); choroid plexus: 82.9787% (minimum 99%, Missing); colon: 90.6977% (minimum 97%, Missing); heart muscle: 92.8571% (minimum 95%, Enhanced); hippocampal formation: 73.5849% (minimum 99%, Missing); hypothalamus: 60.9375% (minimum 99%, Missing); kidney: 73.5849% (minimum 95%, Enhanced); liver: 0.1864% (minimum 99%, Missing); lung: 90.6977% (minimum 95%, Enhanced); midbrain: 79.5918% (minimum 99%, Missing); pancreas: 70.9091% (minimum 95%, Enhanced); pituitary gland: 56.5217% (minimum 99%, Missing); retina: 56.5217% (minimum 99%, Missing); small intestine: 78.0000% (minimum 99%, Missing); spinal cord: 78.0000% (minimum 99%, Missing); stomach: 40.2062% (minimum 80%, Enhanced)",0,6,partial,2088.7,5.8,1,"liver: 2088.7 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138115,CYP2C8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.00121951,-0.397938,-0.988136
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,9,partial,10.1,7.8,9.6,"bone marrow: 10.1 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 3); small intestine: 3.3 nTPM (vital, limit 3); colon: 3.1 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Medium (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Low (Supported); skin 1 / lymphocytes: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Low (Supported); skin 2 / fibrohistiocytic cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138182,KIF20B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.7500% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.5405% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5294% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5294% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 39.8810% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.0556% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.5294% (minimum 99%, Baseline (adaptation disabled)); colon: 68.3673% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.6863% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.3673% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.1579% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5294% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5294% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.8101% (minimum 99%, Baseline (adaptation disabled)); liver: 83.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 82.7160% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.2069% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.5294% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.5405% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.8974% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.1014% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.2075% (minimum 97%, Baseline (adaptation disabled)); retina: 85.8974% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.0130% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.3662% (minimum 99%, Baseline (adaptation disabled)); skin: 73.6264% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.1364% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5294% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.6768% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.6264% (minimum 97%, Baseline (adaptation disabled)); thymus: 41.1043% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 79.7619% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.7808% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.7229% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,10.1,7.8,9.6,"bone marrow: 10.1 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Medium (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Low (Supported); skin 1 / lymphocytes: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Low (Supported); skin 2 / fibrohistiocytic cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138182,KIF20B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.538957,-0.507931,-0.59119
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.5405% (minimum 99%, Missing); amygdala: 98.5294% (minimum 99%, Missing); basal ganglia: 98.5294% (minimum 99%, Missing); bone marrow: 39.8810% (minimum 99%, Missing); cerebellum: 93.0556% (minimum 97%, Supported); cerebral cortex: 89.3333% (minimum 99%, Missing); choroid plexus: 98.5294% (minimum 99%, Missing); colon: 68.3673% (minimum 97%, Missing); duodenum: 65.6863% (minimum 97%, Supported); esophagus: 68.3673% (minimum 97%, Missing); heart muscle: 88.1579% (minimum 97%, Supported); hippocampal formation: 98.5294% (minimum 99%, Missing); hypothalamus: 98.5294% (minimum 99%, Missing); kidney: 84.8101% (minimum 99%, Missing); liver: 83.7500% (minimum 99%, Missing); lung: 82.7160% (minimum 97%, Supported); lymph node: 46.2069% (minimum 97%, Missing); midbrain: 98.5294% (minimum 99%, Missing); pancreas: 90.5405% (minimum 99%, Missing); parathyroid gland: 85.8974% (minimum 90%, Supported); pituitary gland: 97.1014% (minimum 99%, Missing); rectum: 63.2075% (minimum 97%, Missing); retina: 85.8974% (minimum 99%, Missing); salivary gland: 87.0130% (minimum 97%, Missing); skeletal muscle: 94.3662% (minimum 97%, Supported); skin: 73.6264% (minimum 95%, Missing); small intestine: 67.0000% (minimum 97%, Supported); smooth muscle: 76.1364% (minimum 97%, Supported); spinal cord: 98.5294% (minimum 99%, Missing); spleen: 67.6768% (minimum 95%, Missing); stomach: 73.6264% (minimum 97%, Missing); thymus: 41.1043% (minimum 95%, Missing); thyroid gland: 79.7619% (minimum 80%, Supported); tongue: 91.7808% (minimum 97%, Missing); urinary bladder: 80.7229% (minimum 90%, Supported)",0,9,partial,10.1,7.8,9.6,"bone marrow: 10.1 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 3); small intestine: 3.3 nTPM (vital, limit 3); colon: 3.1 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Medium (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Low (Supported); skin 1 / lymphocytes: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Low (Supported); skin 2 / fibrohistiocytic cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138182,KIF20B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.538957,-0.507931,-0.59119
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,1,1.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138336,TET1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.1579% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.3077% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.3077% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.7143% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 85.7143% (minimum 99%, Baseline (adaptation disabled)); lung: 85.7143% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.7143% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.1579% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 44.4444% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 54.5455% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.5882% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.5882% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 38.7097% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.5882% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.7143% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.5,1,1.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138336,TET1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.562903,-0.424545,-0.545556
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 85.7143% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 80.0000% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 63.1579% (minimum 99%, Missing); choroid plexus: 92.3077% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 92.3077% (minimum 99%, Missing); esophagus: 85.7143% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 80.0000% (minimum 99%, Missing); kidney: 80.0000% (minimum 99%, Missing); liver: 85.7143% (minimum 99%, Missing); lung: 85.7143% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 85.7143% (minimum 99%, Missing); parathyroid gland: 63.1579% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 80.0000% (minimum 97%, Missing); retina: 44.4444% (minimum 99%, Missing); salivary gland: 54.5455% (minimum 97%, Missing); skeletal muscle: 60.0000% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 85.7143% (minimum 99%, Missing); smooth muscle: 70.5882% (minimum 99%, Missing); spinal cord: 70.5882% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 75.0000% (minimum 97%, Missing); thymus: 38.7097% (minimum 95%, Missing); thyroid gland: 70.5882% (minimum 95%, Missing); tongue: 80.0000% (minimum 97%, Missing); urinary bladder: 85.7143% (minimum 97%, Missing)",0,80,unavailable,1.5,1,1.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138336,TET1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.562903,-0.424545,-0.545556
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,9.7,14.7,0.5,"tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 9.7 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000138379,MSTN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.1429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.1579% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.1579% (minimum 99%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.7143% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.5455% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.1579% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.1579% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.5882% (minimum 99%, Baseline (adaptation disabled)); liver: 92.3077% (minimum 99%, Baseline (adaptation disabled)); lung: 85.7143% (minimum 99%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.7143% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 28.5714% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 11.0092% (minimum 99%, Baseline (adaptation disabled)); skin: 70.5882% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.7143% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.7143% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 80.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 7.5472% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.7143% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,9.7,14.7,0.5,"tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 9.7 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000138379,MSTN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.244118,-0.894528,-0.879908
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.0000% (minimum 90%, Approved); adrenal gland: 57.1429% (minimum 98%, Approved); amygdala: 63.1579% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); cerebellum: 60.0000% (minimum 98%, Approved); cerebral cortex: 63.1579% (minimum 98%, Approved); colon: 66.6667% (minimum 95%, Approved); duodenum: 85.7143% (minimum 98%, Approved); esophagus: 54.5455% (minimum 95%, Approved); heart muscle: 80.0000% (minimum 98%, Approved); hippocampal formation: 63.1579% (minimum 99%, Missing); hypothalamus: 63.1579% (minimum 99%, Missing); kidney: 70.5882% (minimum 98%, Approved); liver: 92.3077% (minimum 98%, Approved); lung: 85.7143% (minimum 98%, Approved); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 85.7143% (minimum 98%, Approved); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 75.0000% (minimum 95%, Approved); retina: 28.5714% (minimum 99%, Missing); salivary gland: 75.0000% (minimum 95%, Approved); skeletal muscle: 11.0092% (minimum 98%, Approved); skin: 70.5882% (minimum 90%, Approved); small intestine: 85.7143% (minimum 98%, Approved); smooth muscle: 80.0000% (minimum 98%, Approved); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 85.7143% (minimum 90%, Approved); stomach: 85.7143% (minimum 95%, Approved); thyroid gland: 80.0000% (minimum 90%, Approved); tongue: 7.5472% (minimum 97%, Missing); urinary bladder: 85.7143% (minimum 95%, Approved)",0,2,partial,9.7,14.7,0.5,"tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 9.7 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000138379,MSTN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.194118,-0.894528,-0.869908
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,15.6,8.6,10.3,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); lymph node: 8.6 nTPM (protected, limit 2); parathyroid gland: 7.6 nTPM (protected, limit 2); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); urinary bladder: 5.5 nTPM (protected, limit 2); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); tongue: 5.2 nTPM (protected, limit 2); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138380,CARF,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.9365% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.3846% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.6154% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.9593% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.7710% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.9608% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.1135% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.6950% (minimum 99%, Baseline (adaptation disabled)); colon: 80.3846% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.6087% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.7710% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.3230% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.9365% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.9593% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.2774% (minimum 99%, Baseline (adaptation disabled)); liver: 82.9365% (minimum 99%, Baseline (adaptation disabled)); lung: 81.0078% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.8475% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.3230% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.6154% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.6950% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.2772% (minimum 97%, Baseline (adaptation disabled)); retina: 57.2603% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.2835% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.9365% (minimum 99%, Baseline (adaptation disabled)); skin: 74.6429% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.3230% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.5568% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.6429% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.1135% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.2772% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.4352% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.9872% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.0766% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 79.1667% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,15.6,8.6,10.3,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); lymph node: 8.6 nTPM (protected, limit 2); parathyroid gland: 7.6 nTPM (protected, limit 2); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); urinary bladder: 5.5 nTPM (protected, limit 2); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); tongue: 5.2 nTPM (protected, limit 2); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138380,CARF,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.280128,-0.261525,-0.417397
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.9365% (minimum 95%, Missing); adrenal gland: 80.3846% (minimum 99%, Missing); amygdala: 84.6154% (minimum 99%, Missing); basal ganglia: 84.9593% (minimum 99%, Missing); bone marrow: 79.7710% (minimum 99%, Missing); cerebellum: 81.9608% (minimum 99%, Missing); cerebral cortex: 74.1135% (minimum 99%, Missing); choroid plexus: 80.6950% (minimum 99%, Missing); colon: 80.3846% (minimum 97%, Missing); duodenum: 82.6087% (minimum 99%, Missing); esophagus: 79.7710% (minimum 97%, Missing); heart muscle: 81.3230% (minimum 99%, Missing); hippocampal formation: 82.9365% (minimum 99%, Missing); hypothalamus: 84.9593% (minimum 99%, Missing); kidney: 76.2774% (minimum 99%, Missing); liver: 82.9365% (minimum 99%, Missing); lung: 81.0078% (minimum 99%, Missing); lymph node: 70.8475% (minimum 97%, Missing); midbrain: 81.3230% (minimum 99%, Missing); pancreas: 84.6154% (minimum 99%, Missing); parathyroid gland: 73.3333% (minimum 97%, Missing); pituitary gland: 80.6950% (minimum 99%, Missing); rectum: 78.2772% (minimum 97%, Missing); retina: 57.2603% (minimum 99%, Missing); salivary gland: 82.2835% (minimum 97%, Missing); skeletal muscle: 82.9365% (minimum 99%, Missing); skin: 74.6429% (minimum 95%, Missing); small intestine: 81.3230% (minimum 99%, Missing); smooth muscle: 76.5568% (minimum 99%, Missing); spinal cord: 74.6429% (minimum 99%, Missing); spleen: 74.1135% (minimum 95%, Missing); stomach: 78.2772% (minimum 97%, Missing); thymus: 69.4352% (minimum 95%, Missing); thyroid gland: 66.9872% (minimum 95%, Missing); tongue: 80.0766% (minimum 97%, Missing); urinary bladder: 79.1667% (minimum 97%, Missing)",0,3,partial,15.6,8.6,10.3,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); lymph node: 8.6 nTPM (protected, limit 2); parathyroid gland: 7.6 nTPM (protected, limit 2); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); urinary bladder: 5.5 nTPM (protected, limit 2); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); tongue: 5.2 nTPM (protected, limit 2); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138380,CARF,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.280128,-0.261525,-0.417397
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,20.3,4,4.7,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 2); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138400,MDH1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.4444% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.1877% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.3047% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.2000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.8397% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 53.9683% (minimum 99%, Baseline (adaptation disabled)); colon: 95.5823% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.2000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.1515% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.8060% (minimum 99%, Baseline (adaptation disabled)); liver: 98.7552% (minimum 99%, Baseline (adaptation disabled)); lung: 92.2481% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.1877% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.3563% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.6115% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.5610% (minimum 99%, Baseline (adaptation disabled)); retina: 74.1433% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.9677% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.3471% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.7552% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.7480% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.8207% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 83.5088% (minimum 95%, Baseline (adaptation disabled))",0,7,partial,20.3,4,4.7,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138400,MDH1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.114912,-0.113885,-0.450317
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.4444% (minimum 98%, Approved); amygdala: 91.1877% (minimum 99%, Missing); basal ganglia: 85.3047% (minimum 99%, Missing); cerebellum: 95.2000% (minimum 98%, Approved); cerebral cortex: 90.8397% (minimum 98%, Approved); choroid plexus: 53.9683% (minimum 99%, Missing); heart muscle: 95.2000% (minimum 98%, Approved); hippocampal formation: 90.1515% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); kidney: 88.8060% (minimum 98%, Approved); lung: 92.2481% (minimum 99%, Missing); midbrain: 91.1877% (minimum 99%, Missing); pancreas: 96.3563% (minimum 98%, Approved); parathyroid gland: 85.6115% (minimum 95%, Approved); pituitary gland: 72.5610% (minimum 99%, Missing); retina: 74.1433% (minimum 99%, Missing); smooth muscle: 96.7480% (minimum 98%, Approved); spinal cord: 94.8207% (minimum 99%, Missing); thyroid gland: 83.5088% (minimum 90%, Approved)",0,7,partial,20.3,4,4.7,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 2); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138400,MDH1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0649123,-0.0938849,-0.450317
True,compatible,,True,True,False,,0,80,unavailable,0.7,0,0.1,,,0,not_established,not_triggered,,,ENSG00000138483,CCDC54,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.7,0,0.1,,,0,not_established,not_triggered,,,ENSG00000138483,CCDC54,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0491228,0.03,0.0038918
True,compatible,,True,True,True,,0,80,unavailable,0.7,0,0.1,,,0,not_established,not_triggered,,,ENSG00000138483,CCDC54,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0491228,0.03,0.0038918
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,22,2.6,5.4,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); thymus: 5.4 nTPM (manageable, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138587,MNS1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.0954% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.9759% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.5851% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.2281% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.1878% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.7055% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.0233% (minimum 99%, Baseline (adaptation disabled)); colon: 96.2963% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.5102% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.7368% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.1220% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.9450% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.9450% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.1053% (minimum 99%, Baseline (adaptation disabled)); liver: 96.0986% (minimum 99%, Baseline (adaptation disabled)); lung: 93.4132% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.9290% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.3157% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.2271% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.9016% (minimum 97%, Baseline (adaptation disabled)); retina: 91.2281% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0986% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.9079% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.9016% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.2973% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.6000% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.7055% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.6552% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.3548% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,22,2.6,5.4,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); thymus: 5.4 nTPM (manageable, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138587,MNS1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0534483,-0.0226316,-0.309767
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.0954% (minimum 99%, Missing); amygdala: 93.9759% (minimum 99%, Missing); basal ganglia: 91.5851% (minimum 99%, Missing); bone marrow: 91.2281% (minimum 99%, Missing); cerebellum: 86.1878% (minimum 99%, Missing); cerebral cortex: 95.7055% (minimum 99%, Missing); choroid plexus: 68.0233% (minimum 99%, Missing); colon: 96.2963% (minimum 97%, Missing); duodenum: 95.5102% (minimum 99%, Missing); esophagus: 94.7368% (minimum 97%, Missing); heart muscle: 95.1220% (minimum 99%, Missing); hippocampal formation: 91.9450% (minimum 99%, Missing); hypothalamus: 91.9450% (minimum 99%, Missing); kidney: 82.1053% (minimum 99%, Missing); liver: 96.0986% (minimum 99%, Missing); lung: 93.4132% (minimum 99%, Missing); midbrain: 94.9290% (minimum 99%, Missing); pancreas: 95.3157% (minimum 99%, Missing); pituitary gland: 93.2271% (minimum 99%, Missing); rectum: 95.9016% (minimum 97%, Missing); retina: 91.2281% (minimum 99%, Missing); salivary gland: 96.0986% (minimum 97%, Missing); skeletal muscle: 97.9079% (minimum 99%, Missing); small intestine: 95.9016% (minimum 99%, Missing); smooth muscle: 97.2973% (minimum 99%, Missing); spinal cord: 93.6000% (minimum 99%, Missing); stomach: 95.7055% (minimum 97%, Missing); thymus: 89.6552% (minimum 95%, Missing); thyroid gland: 94.3548% (minimum 95%, Missing)",0,80,unavailable,22,2.6,5.4,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); thymus: 5.4 nTPM (manageable, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000138587,MNS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0534483,-0.0226316,-0.309767
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,18.6,11.6,13.5,"bone marrow: 18.6 nTPM (vital, limit 3); thymus: 13.5 nTPM (manageable, limit 5); smooth muscle: 13 nTPM (vital, limit 3); salivary gland: 11.6 nTPM (protected, limit 6); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 6); pancreas: 7.5 nTPM (vital, limit 3); lymph node: 7 nTPM (protected, limit 6); lung: 6.3 nTPM (vital, limit 3); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 3); heart muscle: 3.8 nTPM (vital, limit 3); colon: 3.8 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000138646,HERC5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.3821% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.6452% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.9799% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.2953% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.1337% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7698% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.7723% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.0227% (minimum 99%, Baseline (adaptation disabled)); colon: 93.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.5108% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.7411% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.9324% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.0931% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.0641% (minimum 99%, Baseline (adaptation disabled)); liver: 85.6707% (minimum 99%, Baseline (adaptation disabled)); lung: 89.9200% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.9241% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.1374% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.2261% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.8015% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.3555% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.7411% (minimum 97%, Baseline (adaptation disabled)); retina: 93.9799% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.8909% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.4003% (minimum 99%, Baseline (adaptation disabled)); small intestine: 92.5865% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.2139% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.9324% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.6471% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.2824% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.6313% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.6803% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.6128% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.7393% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,18.6,11.6,13.5,"bone marrow: 18.6 nTPM (vital, limit 1); thymus: 13.5 nTPM (manageable, limit 5); smooth muscle: 13 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 5); salivary gland: 11.6 nTPM (protected, limit 2); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 2); pancreas: 7.5 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); thyroid gland: 5.1 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); retina: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); skeletal muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000138646,HERC5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.143687,-0.141091,-0.238663
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.6452% (minimum 99%, Missing); amygdala: 93.9799% (minimum 99%, Missing); basal ganglia: 94.2953% (minimum 99%, Missing); bone marrow: 75.1337% (minimum 97%, Supported); cerebral cortex: 94.7723% (minimum 97%, Supported); choroid plexus: 85.0227% (minimum 99%, Missing); colon: 93.6667% (minimum 97%, Missing); duodenum: 93.5108% (minimum 97%, Supported); heart muscle: 93.6667% (minimum 97%, Supported); hippocampal formation: 94.9324% (minimum 99%, Missing); hypothalamus: 95.0931% (minimum 99%, Missing); kidney: 90.0641% (minimum 99%, Missing); liver: 85.6707% (minimum 99%, Missing); lung: 89.9200% (minimum 97%, Supported); lymph node: 88.9241% (minimum 90%, Supported); midbrain: 94.1374% (minimum 99%, Missing); pancreas: 88.2261% (minimum 97%, Supported); parathyroid gland: 85.8015% (minimum 90%, Supported); pituitary gland: 93.3555% (minimum 99%, Missing); rectum: 95.7411% (minimum 97%, Missing); retina: 93.9799% (minimum 99%, Missing); salivary gland: 82.8909% (minimum 90%, Supported); small intestine: 92.5865% (minimum 99%, Missing); smooth muscle: 81.2139% (minimum 97%, Supported); spinal cord: 94.9324% (minimum 99%, Missing); stomach: 92.2824% (minimum 97%, Missing); thymus: 80.6313% (minimum 95%, Missing); tongue: 94.6128% (minimum 97%, Missing)",0,3,partial,18.6,11.6,13.5,"bone marrow: 18.6 nTPM (vital, limit 3); thymus: 13.5 nTPM (manageable, limit 5); smooth muscle: 13 nTPM (vital, limit 3); salivary gland: 11.6 nTPM (protected, limit 6); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 6); pancreas: 7.5 nTPM (vital, limit 3); lymph node: 7 nTPM (protected, limit 6); lung: 6.3 nTPM (vital, limit 3); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 3); heart muscle: 3.8 nTPM (vital, limit 3); colon: 3.8 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000138646,HERC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.143687,-0.0710914,-0.218663
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,13.3,2.9,1.1,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138669,PRKG2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.5660% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.9592% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.7586% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.4286% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.0495% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9691% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.7586% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9691% (minimum 99%, Baseline (adaptation disabled)); colon: 80.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 49.4845% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.4194% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.0647% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.4865% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.2105% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9691% (minimum 99%, Baseline (adaptation disabled)); lung: 73.8462% (minimum 99%, Baseline (adaptation disabled)); midbrain: 88.0734% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.0734% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 82.0513% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.8000% (minimum 97%, Baseline (adaptation disabled)); retina: 96.9697% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.9697% (minimum 97%, Baseline (adaptation disabled)); skin: 89.7196% (minimum 95%, Baseline (adaptation disabled)); small intestine: 41.9214% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.0495% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.1176% (minimum 99%, Baseline (adaptation disabled)); stomach: 91.4286% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.5660% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.4286% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.0495% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,13.3,2.9,1.1,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138669,PRKG2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0528037,-0.202,-0.570786
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.5660% (minimum 95%, Missing); adrenal gland: 97.9592% (minimum 99%, Missing); amygdala: 82.7586% (minimum 99%, Missing); basal ganglia: 91.4286% (minimum 99%, Missing); bone marrow: 95.0495% (minimum 99%, Missing); cerebellum: 98.9691% (minimum 99%, Missing); cerebral cortex: 82.7586% (minimum 99%, Missing); choroid plexus: 98.9691% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); duodenum: 49.4845% (minimum 99%, Missing); esophagus: 77.4194% (minimum 97%, Missing); heart muscle: 69.0647% (minimum 99%, Missing); hippocampal formation: 86.4865% (minimum 99%, Missing); hypothalamus: 84.2105% (minimum 99%, Missing); kidney: 96.0000% (minimum 99%, Missing); liver: 98.9691% (minimum 99%, Missing); lung: 73.8462% (minimum 99%, Missing); midbrain: 88.0734% (minimum 99%, Missing); pancreas: 88.0734% (minimum 99%, Missing); pituitary gland: 82.0513% (minimum 99%, Missing); rectum: 76.8000% (minimum 97%, Missing); retina: 96.9697% (minimum 99%, Missing); salivary gland: 96.9697% (minimum 97%, Missing); skin: 89.7196% (minimum 95%, Missing); small intestine: 41.9214% (minimum 99%, Missing); smooth muscle: 95.0495% (minimum 99%, Missing); spinal cord: 94.1176% (minimum 99%, Missing); stomach: 91.4286% (minimum 97%, Missing); thymus: 90.5660% (minimum 95%, Missing); thyroid gland: 91.4286% (minimum 95%, Missing); urinary bladder: 95.0495% (minimum 97%, Missing)",0,0,routine_complete,13.3,2.9,1.1,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138669,PRKG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0528037,-0.202,-0.570786
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,5.8,0.1,"lymph node: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000138684,IL21,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"lymph node: 10.7692% (minimum 97%, Baseline (adaptation disabled)); spleen: 87.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.5000% (minimum 97%, Baseline (adaptation disabled)); thymus: 87.5000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 77.7778% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0,5.8,0.1,"lymph node: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000138684,IL21,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,-0.075,-0.862308,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"lymph node: 10.7692% (minimum 97%, Missing); spleen: 87.5000% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thymus: 87.5000% (minimum 95%, Missing); urinary bladder: 77.7778% (minimum 97%, Missing)",0,80,unavailable,0,5.8,0.1,"lymph node: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000138684,IL21,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,-0.075,-0.862308,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,60.4,40.9,30.3,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 2); parathyroid gland: 40.9 nTPM (protected, limit 4); spinal cord: 40.1 nTPM (vital, limit 1); skeletal muscle: 40.1 nTPM (vital, limit 2); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 2); cerebral cortex: 36.6 nTPM (vital, limit 2); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 2); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 2); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (manageable, limit 10); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); spleen: 25.7 nTPM (manageable, limit 10); kidney: 24.6 nTPM (vital, limit 1); pancreas: 24 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 2); urinary bladder: 23.7 nTPM (protected, limit 2); stomach: 22.5 nTPM (protected, limit 2); heart muscle: 22.1 nTPM (vital, limit 1); salivary gland: 21.7 nTPM (protected, limit 4); skin: 21.5 nTPM (manageable, limit 5); liver: 17.8 nTPM (vital, limit 2); esophagus: 16.9 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 14 nTPM (protected, limit 2); smooth muscle: 13.8 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 4); duodenum: 11.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000138688,BLTP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.8580% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.6168% (minimum 99%, Baseline (adaptation disabled)); amygdala: 55.2198% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 50.6297% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 51.2102% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.6683% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 52.3438% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 54.9180% (minimum 99%, Baseline (adaptation disabled)); colon: 58.4302% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.6062% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.4028% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.5265% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.9180% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.7719% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.0370% (minimum 99%, Baseline (adaptation disabled)); liver: 69.3103% (minimum 99%, Baseline (adaptation disabled)); lung: 59.7325% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.6062% (minimum 97%, Baseline (adaptation disabled)); midbrain: 54.3243% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.6168% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.5684% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 46.6899% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.1697% (minimum 97%, Baseline (adaptation disabled)); retina: 39.9602% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.9435% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.0623% (minimum 99%, Baseline (adaptation disabled)); skin: 65.1540% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.4675% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 74.4444% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.0623% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.0015% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.1148% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.0247% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.0213% (minimum 95%, Baseline (adaptation disabled)); tongue: 54.9932% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.9108% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,60.4,40.9,30.3,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 1); parathyroid gland: 40.9 nTPM (protected, limit 2); spinal cord: 40.1 nTPM (vital, limit 1); skeletal muscle: 40.1 nTPM (vital, limit 1); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 1); cerebral cortex: 36.6 nTPM (vital, limit 1); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 2); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 2); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (manageable, limit 5); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); spleen: 25.7 nTPM (manageable, limit 5); kidney: 24.6 nTPM (vital, limit 1); pancreas: 24 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 1); urinary bladder: 23.7 nTPM (protected, limit 2); stomach: 22.5 nTPM (protected, limit 2); heart muscle: 22.1 nTPM (vital, limit 1); salivary gland: 21.7 nTPM (protected, limit 2); skin: 21.5 nTPM (manageable, limit 5); liver: 17.8 nTPM (vital, limit 1); esophagus: 16.9 nTPM (protected, limit 2); thymus: 16.4 nTPM (manageable, limit 5); rectum: 14 nTPM (protected, limit 2); smooth muscle: 13.8 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 2); duodenum: 11.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000138688,BLTP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.379787,-0.474316,-0.590398
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.8580% (minimum 90%, Approved); adrenal gland: 62.6168% (minimum 98%, Approved); amygdala: 55.2198% (minimum 99%, Missing); basal ganglia: 50.6297% (minimum 99%, Missing); bone marrow: 51.2102% (minimum 98%, Approved); cerebellum: 48.6683% (minimum 98%, Approved); cerebral cortex: 52.3438% (minimum 98%, Approved); choroid plexus: 54.9180% (minimum 99%, Missing); colon: 58.4302% (minimum 97%, Missing); duodenum: 77.6062% (minimum 99%, Missing); esophagus: 70.4028% (minimum 95%, Approved); heart muscle: 64.5265% (minimum 99%, Missing); hippocampal formation: 54.9180% (minimum 99%, Missing); hypothalamus: 58.7719% (minimum 99%, Missing); kidney: 62.0370% (minimum 99%, Missing); liver: 69.3103% (minimum 98%, Approved); lung: 59.7325% (minimum 99%, Missing); lymph node: 77.6062% (minimum 95%, Approved); midbrain: 54.3243% (minimum 99%, Missing); pancreas: 62.6168% (minimum 99%, Missing); parathyroid gland: 49.5684% (minimum 95%, Approved); pituitary gland: 46.6899% (minimum 99%, Missing); rectum: 74.1697% (minimum 97%, Missing); retina: 39.9602% (minimum 99%, Missing); salivary gland: 64.9435% (minimum 95%, Approved); skeletal muscle: 50.0623% (minimum 98%, Approved); skin: 65.1540% (minimum 95%, Missing); small intestine: 59.4675% (minimum 99%, Missing); smooth muscle: 74.4444% (minimum 99%, Missing); spinal cord: 50.0623% (minimum 99%, Missing); spleen: 61.0015% (minimum 90%, Approved); stomach: 64.1148% (minimum 97%, Missing); thymus: 71.0247% (minimum 95%, Missing); thyroid gland: 57.0213% (minimum 95%, Missing); tongue: 54.9932% (minimum 97%, Missing); urinary bladder: 62.9108% (minimum 97%, Missing)",0,7,partial,60.4,40.9,30.3,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 2); parathyroid gland: 40.9 nTPM (protected, limit 4); spinal cord: 40.1 nTPM (vital, limit 1); skeletal muscle: 40.1 nTPM (vital, limit 2); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 2); cerebral cortex: 36.6 nTPM (vital, limit 2); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 2); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 2); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (manageable, limit 10); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); spleen: 25.7 nTPM (manageable, limit 10); kidney: 24.6 nTPM (vital, limit 1); pancreas: 24 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 2); urinary bladder: 23.7 nTPM (protected, limit 2); stomach: 22.5 nTPM (protected, limit 2); heart muscle: 22.1 nTPM (vital, limit 1); salivary gland: 21.7 nTPM (protected, limit 4); skin: 21.5 nTPM (manageable, limit 5); liver: 17.8 nTPM (vital, limit 2); esophagus: 16.9 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 14 nTPM (protected, limit 2); smooth muscle: 13.8 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 4); duodenum: 11.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000138688,BLTP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.379787,-0.454316,-0.590398
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,9.9,5.5,8.9,"bone marrow: 9.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: High (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138778,CENPE,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.9091% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.2381% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.5610% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.2381% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 28.7770% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.9091% (minimum 99%, Baseline (adaptation disabled)); colon: 70.1754% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.7273% (minimum 99%, Baseline (adaptation disabled)); esophagus: 67.7966% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.5610% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.2381% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.2381% (minimum 99%, Baseline (adaptation disabled)); liver: 88.8889% (minimum 99%, Baseline (adaptation disabled)); lung: 85.1064% (minimum 99%, Baseline (adaptation disabled)); lymph node: 42.1053% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.2381% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.5610% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.0233% (minimum 97%, Baseline (adaptation disabled)); rectum: 67.7966% (minimum 97%, Baseline (adaptation disabled)); retina: 90.9091% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.0233% (minimum 97%, Baseline (adaptation disabled)); skin: 67.7966% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.4314% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.2381% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.4314% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 31.0078% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.9565% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.1064% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,9.9,5.5,8.9,"bone marrow: 9.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: High (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138778,CENPE,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.639922,-0.548947,-0.70223
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 97.5610% (minimum 99%, Missing); basal ganglia: 95.2381% (minimum 99%, Missing); bone marrow: 28.7770% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 95%, Enhanced); colon: 70.1754% (minimum 80%, Enhanced); duodenum: 72.7273% (minimum 99%, Missing); esophagus: 67.7966% (minimum 97%, Missing); heart muscle: 95.2381% (minimum 99%, Missing); hippocampal formation: 97.5610% (minimum 99%, Missing); hypothalamus: 95.2381% (minimum 99%, Missing); kidney: 95.2381% (minimum 99%, Missing); liver: 88.8889% (minimum 99%, Missing); lung: 85.1064% (minimum 99%, Missing); lymph node: 42.1053% (minimum 97%, Missing); midbrain: 95.2381% (minimum 99%, Missing); rectum: 67.7966% (minimum 97%, Missing); retina: 90.9091% (minimum 99%, Missing); salivary gland: 93.0233% (minimum 97%, Missing); skin: 67.7966% (minimum 95%, Missing); small intestine: 71.4286% (minimum 95%, Enhanced); smooth muscle: 78.4314% (minimum 99%, Missing); spinal cord: 95.2381% (minimum 99%, Missing); stomach: 80.0000% (minimum 97%, Missing); thymus: 31.0078% (minimum 95%, Missing); tongue: 86.9565% (minimum 97%, Missing); urinary bladder: 85.1064% (minimum 97%, Missing)",0,7,partial,9.9,5.5,8.9,"bone marrow: 9.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: High (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000138778,CENPE,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.639922,-0.548947,-0.70223
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,7.1,4.8,5.2,"retina: 7.1 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); esophagus: 4.8 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); duodenum: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000138780,GSTCD,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.0312% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.8790% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.9474% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.3582% (minimum 99%, Baseline (adaptation disabled)); colon: 74.4681% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.7692% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.6275% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.6772% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.6774% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.4286% (minimum 99%, Baseline (adaptation disabled)); liver: 81.3953% (minimum 99%, Baseline (adaptation disabled)); lung: 80.1527% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.2059% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.5396% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.0312% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.9167% (minimum 97%, Baseline (adaptation disabled)); retina: 59.6591% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 76.0870% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.3582% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.9167% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.3953% (minimum 99%, Baseline (adaptation disabled)); spleen: 79.5455% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.6423% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.8790% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.7692% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.0312% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,7.1,4.8,5.2,"retina: 7.1 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); esophagus: 4.8 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); duodenum: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000138780,GSTCD,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.28121,-0.283725,-0.393409
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Missing); adrenal gland: 82.0312% (minimum 99%, Missing); amygdala: 84.0000% (minimum 99%, Missing); basal ganglia: 84.0000% (minimum 99%, Missing); bone marrow: 66.8790% (minimum 99%, Missing); cerebellum: 78.9474% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); choroid plexus: 78.3582% (minimum 99%, Missing); colon: 74.4681% (minimum 97%, Missing); duodenum: 80.7692% (minimum 99%, Missing); esophagus: 68.6275% (minimum 97%, Missing); heart muscle: 82.6772% (minimum 99%, Missing); hippocampal formation: 84.6774% (minimum 99%, Missing); hypothalamus: 84.0000% (minimum 99%, Missing); kidney: 71.4286% (minimum 99%, Missing); liver: 81.3953% (minimum 99%, Missing); lung: 80.1527% (minimum 99%, Missing); lymph node: 70.0000% (minimum 97%, Missing); midbrain: 83.3333% (minimum 99%, Missing); pancreas: 77.2059% (minimum 99%, Missing); parathyroid gland: 75.5396% (minimum 97%, Missing); pituitary gland: 82.0312% (minimum 99%, Missing); rectum: 72.9167% (minimum 97%, Missing); retina: 59.6591% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 84.0000% (minimum 99%, Missing); skin: 76.0870% (minimum 95%, Missing); small intestine: 78.3582% (minimum 99%, Missing); smooth muscle: 72.9167% (minimum 99%, Missing); spinal cord: 81.3953% (minimum 99%, Missing); spleen: 79.5455% (minimum 95%, Missing); stomach: 76.6423% (minimum 97%, Missing); thymus: 70.0000% (minimum 95%, Missing); thyroid gland: 66.8790% (minimum 95%, Missing); tongue: 80.7692% (minimum 97%, Missing); urinary bladder: 82.0312% (minimum 97%, Missing)",0,5,partial,7.1,4.8,5.2,"retina: 7.1 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); esophagus: 4.8 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); duodenum: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000138780,GSTCD,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.28121,-0.283725,-0.393409
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000138813,C4orf17,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000138813,C4orf17,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000138813,C4orf17,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000138892,TTLL8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000138892,TTLL8,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000138892,TTLL8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,4,3.6,3.5,"bone marrow: 4 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); esophagus: 2.1 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000139133,ALG10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 55.9322% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.1892% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 45.2055% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.6154% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.7442% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.8421% (minimum 99%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.3469% (minimum 99%, Baseline (adaptation disabled)); esophagus: 61.1111% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.7442% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.1892% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.7059% (minimum 99%, Baseline (adaptation disabled)); liver: 54.0984% (minimum 99%, Baseline (adaptation disabled)); lung: 64.7059% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.8261% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.7500% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.6154% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.4615% (minimum 97%, Baseline (adaptation disabled)); retina: 50.7692% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.7500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.5714% (minimum 99%, Baseline (adaptation disabled)); skin: 63.4615% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.1111% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.1892% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.0984% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.4615% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.5294% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 73.3333% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.3333% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,4,3.6,3.5,"bone marrow: 4 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); esophagus: 2.1 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000139133,ALG10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.464706,-0.491739,-0.537945
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 90%, Approved); adrenal gland: 55.9322% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 89.1892% (minimum 99%, Missing); bone marrow: 45.2055% (minimum 99%, Missing); cerebellum: 84.6154% (minimum 99%, Missing); cerebral cortex: 76.7442% (minimum 99%, Missing); choroid plexus: 86.8421% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 67.3469% (minimum 99%, Missing); esophagus: 61.1111% (minimum 97%, Missing); heart muscle: 76.7442% (minimum 99%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 89.1892% (minimum 99%, Missing); kidney: 64.7059% (minimum 99%, Missing); liver: 54.0984% (minimum 99%, Missing); lung: 64.7059% (minimum 99%, Missing); lymph node: 47.8261% (minimum 97%, Missing); midbrain: 91.6667% (minimum 99%, Missing); pancreas: 68.7500% (minimum 99%, Missing); parathyroid gland: 60.0000% (minimum 97%, Missing); pituitary gland: 84.6154% (minimum 99%, Missing); rectum: 63.4615% (minimum 97%, Missing); retina: 50.7692% (minimum 99%, Missing); salivary gland: 68.7500% (minimum 97%, Missing); skeletal muscle: 78.5714% (minimum 99%, Missing); skin: 63.4615% (minimum 95%, Missing); small intestine: 66.0000% (minimum 99%, Missing); smooth muscle: 61.1111% (minimum 99%, Missing); spinal cord: 89.1892% (minimum 99%, Missing); spleen: 54.0984% (minimum 95%, Missing); stomach: 63.4615% (minimum 97%, Missing); thymus: 48.5294% (minimum 95%, Missing); thyroid gland: 55.0000% (minimum 95%, Missing); tongue: 73.3333% (minimum 97%, Missing); urinary bladder: 73.3333% (minimum 97%, Missing)",0,1,partial,4,3.6,3.5,"bone marrow: 4 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); esophagus: 2.1 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000139133,ALG10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.464706,-0.491739,-0.537945
True,compatible,,True,True,False,,0,80,unavailable,0.4,0.4,1.7,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000139151,PLCZ1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.4,0.4,1.7,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000139151,PLCZ1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0102804,0.0203614,0.000361446
True,compatible,,True,True,True,,0,80,unavailable,0.4,0.4,1.7,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000139151,PLCZ1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0102804,0.0203614,0.000361446
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,9.4,7.5,3.5,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 2); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000139160,ETFBKMT,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.9189% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.9545% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.8310% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.8630% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.3846% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.9189% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.3846% (minimum 99%, Baseline (adaptation disabled)); colon: 68.9189% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.5570% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.9189% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.3023% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.8310% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.8310% (minimum 99%, Baseline (adaptation disabled)); kidney: 46.3636% (minimum 99%, Baseline (adaptation disabled)); liver: 35.1724% (minimum 99%, Baseline (adaptation disabled)); lung: 71.8310% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.1194% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.8310% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.7143% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.5773% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.1053% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 46.3636% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.8630% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 41.1290% (minimum 99%, Baseline (adaptation disabled)); skin: 68.9189% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.8310% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.7500% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.9189% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.2338% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.3023% (minimum 95%, Baseline (adaptation disabled)); tongue: 40.4762% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.8310% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,9.4,7.5,3.5,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 2); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000139160,ETFBKMT,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.356977,-0.565238,-0.638276
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.9189% (minimum 95%, Uncertain); adrenal gland: 57.9545% (minimum 99%, Missing); amygdala: 71.8310% (minimum 99%, Missing); basal ganglia: 68.0000% (minimum 99%, Missing); bone marrow: 69.8630% (minimum 99%, Uncertain); cerebellum: 65.3846% (minimum 99%, Missing); cerebral cortex: 68.9189% (minimum 99%, Missing); choroid plexus: 65.3846% (minimum 99%, Missing); colon: 68.9189% (minimum 97%, Missing); duodenum: 64.5570% (minimum 99%, Missing); esophagus: 68.9189% (minimum 97%, Missing); heart muscle: 59.3023% (minimum 99%, Missing); hippocampal formation: 71.8310% (minimum 99%, Missing); hypothalamus: 71.8310% (minimum 99%, Missing); kidney: 46.3636% (minimum 99%, Missing); liver: 35.1724% (minimum 99%, Missing); lung: 71.8310% (minimum 99%, Missing); lymph node: 76.1194% (minimum 97%, Uncertain); midbrain: 71.8310% (minimum 99%, Missing); pancreas: 60.7143% (minimum 99%, Missing); parathyroid gland: 52.5773% (minimum 97%, Missing); pituitary gland: 67.1053% (minimum 99%, Missing); rectum: 68.0000% (minimum 97%, Missing); retina: 46.3636% (minimum 99%, Missing); salivary gland: 69.8630% (minimum 97%, Missing); skeletal muscle: 41.1290% (minimum 99%, Missing); skin: 68.9189% (minimum 95%, Missing); small intestine: 71.8310% (minimum 99%, Missing); smooth muscle: 63.7500% (minimum 99%, Uncertain); spinal cord: 68.9189% (minimum 99%, Missing); spleen: 68.0000% (minimum 95%, Uncertain); stomach: 66.2338% (minimum 97%, Missing); thymus: 85.0000% (minimum 95%, Missing); thyroid gland: 59.3023% (minimum 95%, Missing); tongue: 40.4762% (minimum 97%, Missing); urinary bladder: 71.8310% (minimum 97%, Missing)",0,2,partial,9.4,7.5,3.5,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 2); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); rectum: 2.4 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000139160,ETFBKMT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.356977,-0.565238,-0.638276
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,22.7,43.9,22.5,"stomach: 43.9 nTPM (protected, limit 2); colon: 26.3 nTPM (protected, limit 2); duodenum: 22.7 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 2); cerebral cortex: 16.4 nTPM (vital, limit 1); spleen: 16.3 nTPM (manageable, limit 10); small intestine: 15 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); rectum: 14.9 nTPM (protected, limit 2); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (manageable, limit 5); adrenal gland: 14 nTPM (vital, limit 1); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 2); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 2); spinal cord: 11.1 nTPM (vital, limit 1); esophagus: 10.5 nTPM (protected, limit 2); parathyroid gland: 10.5 nTPM (protected, limit 4); pancreas: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (manageable, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 2); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000139163,ETNK1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.0900% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.7039% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.7305% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 67.0175% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.4148% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.4148% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.8028% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.9008% (minimum 99%, Baseline (adaptation disabled)); colon: 42.0705% (minimum 97%, Baseline (adaptation disabled)); duodenum: 45.6938% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.5270% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.9008% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.0175% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 56.8452% (minimum 99%, Baseline (adaptation disabled)); kidney: 51.7615% (minimum 99%, Baseline (adaptation disabled)); liver: 51.9022% (minimum 99%, Baseline (adaptation disabled)); lung: 61.0224% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.9086% (minimum 97%, Baseline (adaptation disabled)); midbrain: 65.8621% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.7458% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.5270% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.9506% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.1765% (minimum 97%, Baseline (adaptation disabled)); retina: 52.0436% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.2179% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.0956% (minimum 99%, Baseline (adaptation disabled)); skin: 56.1765% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.0117% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.3485% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.2450% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.9548% (minimum 95%, Baseline (adaptation disabled)); stomach: 30.3175% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.9135% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.5301% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.9592% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.7458% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,22.7,43.9,22.5,"stomach: 43.9 nTPM (protected, limit 2); colon: 26.3 nTPM (protected, limit 2); duodenum: 22.7 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 2); cerebral cortex: 16.4 nTPM (vital, limit 1); spleen: 16.3 nTPM (manageable, limit 5); small intestine: 15 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); rectum: 14.9 nTPM (protected, limit 2); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (manageable, limit 5); adrenal gland: 14 nTPM (vital, limit 1); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 2); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); esophagus: 10.5 nTPM (protected, limit 2); parathyroid gland: 10.5 nTPM (protected, limit 2); pancreas: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (manageable, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000139163,ETNK1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.490865,-0.666825,-0.533062
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.0900% (minimum 95%, Missing); adrenal gland: 57.7039% (minimum 99%, Missing); amygdala: 67.7305% (minimum 99%, Missing); basal ganglia: 67.0175% (minimum 99%, Missing); bone marrow: 61.4148% (minimum 98%, Approved); cerebellum: 61.4148% (minimum 99%, Missing); cerebral cortex: 53.8028% (minimum 99%, Missing); choroid plexus: 72.9008% (minimum 99%, Missing); colon: 42.0705% (minimum 97%, Missing); duodenum: 45.6938% (minimum 99%, Missing); esophagus: 64.5270% (minimum 97%, Missing); heart muscle: 72.9008% (minimum 99%, Missing); hippocampal formation: 67.0175% (minimum 99%, Missing); hypothalamus: 56.8452% (minimum 99%, Missing); kidney: 51.7615% (minimum 99%, Missing); liver: 51.9022% (minimum 99%, Missing); lung: 61.0224% (minimum 99%, Missing); lymph node: 52.9086% (minimum 97%, Missing); midbrain: 65.8621% (minimum 99%, Missing); pancreas: 64.7458% (minimum 99%, Missing); parathyroid gland: 64.5270% (minimum 95%, Approved); pituitary gland: 58.9506% (minimum 99%, Missing); rectum: 56.1765% (minimum 97%, Missing); retina: 52.0436% (minimum 99%, Missing); salivary gland: 61.2179% (minimum 97%, Missing); skeletal muscle: 76.0956% (minimum 99%, Missing); skin: 56.1765% (minimum 95%, Missing); small intestine: 56.0117% (minimum 99%, Missing); smooth muscle: 72.3485% (minimum 98%, Approved); spinal cord: 63.2450% (minimum 99%, Missing); spleen: 53.9548% (minimum 90%, Approved); stomach: 30.3175% (minimum 97%, Missing); thymus: 45.9135% (minimum 95%, Missing); thyroid gland: 57.5301% (minimum 95%, Missing); tongue: 77.9592% (minimum 97%, Missing); urinary bladder: 64.7458% (minimum 97%, Missing)",0,4,partial,22.7,43.9,22.5,"stomach: 43.9 nTPM (protected, limit 2); colon: 26.3 nTPM (protected, limit 2); duodenum: 22.7 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 2); cerebral cortex: 16.4 nTPM (vital, limit 1); spleen: 16.3 nTPM (manageable, limit 10); small intestine: 15 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); rectum: 14.9 nTPM (protected, limit 2); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (manageable, limit 5); adrenal gland: 14 nTPM (vital, limit 1); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 2); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 2); spinal cord: 11.1 nTPM (vital, limit 1); esophagus: 10.5 nTPM (protected, limit 2); parathyroid gland: 10.5 nTPM (protected, limit 4); pancreas: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (manageable, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 2); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000139163,ETNK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.490865,-0.666825,-0.533062
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.9,3.9,3.1,"kidney: 6.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000139304,PTPRQ,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.6140% (minimum 95%, Baseline (adaptation disabled)); basal ganglia: 86.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.2963% (minimum 99%, Baseline (adaptation disabled)); colon: 96.2963% (minimum 97%, Baseline (adaptation disabled)); esophagus: 96.2963% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.2703% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.2963% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.8571% (minimum 99%, Baseline (adaptation disabled)); kidney: 27.3684% (minimum 99%, Baseline (adaptation disabled)); lung: 54.1667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.2857% (minimum 97%, Baseline (adaptation disabled)); pancreas: 89.6552% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.2963% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.2963% (minimum 99%, Baseline (adaptation disabled)); retina: 78.7879% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.2963% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.2963% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.8571% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.1481% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 40.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.9,3.9,3.1,"kidney: 6.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000139304,PTPRQ,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.49386,-0.57,-0.716316
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.6140% (minimum 95%, Missing); basal ganglia: 86.6667% (minimum 99%, Missing); cerebral cortex: 96.2963% (minimum 99%, Missing); colon: 96.2963% (minimum 97%, Missing); esophagus: 96.2963% (minimum 97%, Missing); heart muscle: 70.2703% (minimum 99%, Missing); hippocampal formation: 96.2963% (minimum 99%, Missing); hypothalamus: 92.8571% (minimum 99%, Missing); kidney: 27.3684% (minimum 99%, Missing); lung: 54.1667% (minimum 99%, Missing); lymph node: 74.2857% (minimum 97%, Missing); pancreas: 89.6552% (minimum 99%, Missing); parathyroid gland: 96.2963% (minimum 97%, Missing); pituitary gland: 96.2963% (minimum 99%, Missing); retina: 78.7879% (minimum 99%, Missing); salivary gland: 96.2963% (minimum 97%, Missing); skeletal muscle: 92.8571% (minimum 99%, Missing); stomach: 96.2963% (minimum 97%, Missing); thymus: 92.8571% (minimum 95%, Missing); thyroid gland: 48.1481% (minimum 95%, Missing); urinary bladder: 40.0000% (minimum 97%, Missing)",0,80,unavailable,6.9,3.9,3.1,"kidney: 6.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000139304,PTPRQ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.49386,-0.57,-0.716316
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,36.7,24.6,21.9,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 2); thymus: 21.9 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 2); parathyroid gland: 14.4 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 2); rectum: 9.4 nTPM (protected, limit 2); urinary bladder: 9.2 nTPM (protected, limit 2); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); retina: 7 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); duodenum: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000139350,NEDD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.2397% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.3509% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.1575% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.4531% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.2632% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.4167% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.0722% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.4478% (minimum 99%, Baseline (adaptation disabled)); colon: 74.1100% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.8456% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.2454% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.0126% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.4531% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.5138% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.6984% (minimum 99%, Baseline (adaptation disabled)); liver: 78.9655% (minimum 99%, Baseline (adaptation disabled)); lung: 72.9299% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.4222% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.8039% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.8456% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.3941% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.0902% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.8978% (minimum 97%, Baseline (adaptation disabled)); retina: 76.5886% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.6271% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 38.4228% (minimum 99%, Baseline (adaptation disabled)); skin: 74.1100% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.3649% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.5070% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.7424% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.7883% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.5886% (minimum 97%, Baseline (adaptation disabled)); thymus: 51.1161% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 69.1843% (minimum 95%, Baseline (adaptation disabled)); tongue: 48.2105% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.3396% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,36.7,24.6,21.9,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 2); thymus: 21.9 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 2); parathyroid gland: 14.4 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 2); rectum: 9.4 nTPM (protected, limit 2); urinary bladder: 9.2 nTPM (protected, limit 2); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); retina: 7 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); duodenum: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000139350,NEDD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.438839,-0.487895,-0.605772
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.2397% (minimum 95%, Missing); adrenal gland: 80.3509% (minimum 99%, Missing); amygdala: 90.1575% (minimum 99%, Missing); basal ganglia: 89.4531% (minimum 99%, Missing); bone marrow: 60.2632% (minimum 99%, Missing); cerebellum: 95.4167% (minimum 99%, Missing); cerebral cortex: 87.0722% (minimum 99%, Missing); choroid plexus: 85.4478% (minimum 99%, Missing); colon: 74.1100% (minimum 97%, Missing); duodenum: 76.8456% (minimum 99%, Missing); esophagus: 70.2454% (minimum 97%, Missing); heart muscle: 72.0126% (minimum 99%, Missing); hippocampal formation: 89.4531% (minimum 99%, Missing); hypothalamus: 90.5138% (minimum 99%, Missing); kidney: 72.6984% (minimum 99%, Missing); liver: 78.9655% (minimum 99%, Missing); lung: 72.9299% (minimum 99%, Missing); lymph node: 60.4222% (minimum 97%, Missing); midbrain: 89.8039% (minimum 99%, Missing); pancreas: 76.8456% (minimum 99%, Missing); parathyroid gland: 61.3941% (minimum 97%, Missing); pituitary gland: 86.0902% (minimum 99%, Missing); rectum: 70.8978% (minimum 97%, Missing); retina: 76.5886% (minimum 99%, Missing); salivary gland: 77.6271% (minimum 97%, Missing); skeletal muscle: 38.4228% (minimum 99%, Missing); skin: 74.1100% (minimum 95%, Missing); small intestine: 77.3649% (minimum 99%, Missing); smooth muscle: 64.5070% (minimum 99%, Missing); spinal cord: 86.7424% (minimum 99%, Missing); spleen: 63.7883% (minimum 95%, Missing); stomach: 76.5886% (minimum 97%, Missing); thymus: 51.1161% (minimum 95%, Missing); thyroid gland: 69.1843% (minimum 95%, Missing); tongue: 48.2105% (minimum 97%, Missing); urinary bladder: 71.3396% (minimum 97%, Missing)",0,2,partial,36.7,24.6,21.9,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 2); thymus: 21.9 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 2); parathyroid gland: 14.4 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 2); rectum: 9.4 nTPM (protected, limit 2); urinary bladder: 9.2 nTPM (protected, limit 2); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); retina: 7 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); duodenum: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000139350,NEDD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.438839,-0.487895,-0.605772
True,compatible,,True,True,False,,0,1,partial,0.7,0.5,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus,ENSG00000139351,SYCP3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.7,0.5,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus,ENSG00000139351,SYCP3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0475217,0.0238272,0.00137931
True,compatible,,True,True,True,,0,1,partial,0.7,0.5,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus,ENSG00000139351,SYCP3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0487593,0.03,0.00875931
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000139445,FOXN4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.2301% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.6897% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2301% (minimum 99%, Baseline (adaptation disabled)); liver: 93.2773% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.2301% (minimum 99%, Baseline (adaptation disabled)); retina: 96.5217% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.2301% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000139445,FOXN4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0236842,0.00368421,-0.0572269
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.2301% (minimum 99%, Missing); choroid plexus: 95.6897% (minimum 99%, Missing); kidney: 98.2301% (minimum 99%, Missing); liver: 93.2773% (minimum 99%, Missing); pituitary gland: 98.2301% (minimum 99%, Missing); retina: 96.5217% (minimum 99%, Missing); skeletal muscle: 98.2301% (minimum 99%, Missing)",0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000139445,FOXN4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0236842,0.00368421,-0.0572269
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,25.4,22.5,25.8,"thymus: 25.8 nTPM (manageable, limit 5); retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 2); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 2); bone marrow: 19.2 nTPM (vital, limit 2); skeletal muscle: 18.8 nTPM (vital, limit 2); thyroid gland: 18.3 nTPM (manageable, limit 5); urinary bladder: 17.9 nTPM (protected, limit 2); lung: 16.9 nTPM (vital, limit 1); cerebellum: 16.2 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 10); hypothalamus: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 2); rectum: 12.4 nTPM (protected, limit 2); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 2); adrenal gland: 11.4 nTPM (vital, limit 2); spleen: 11.3 nTPM (manageable, limit 5); skin: 11.3 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); pancreas: 10.5 nTPM (vital, limit 1); salivary gland: 10.4 nTPM (protected, limit 2); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 2); choroid plexus: 4.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000139496,NUP58,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.5618% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.3852% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.1460% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.9636% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.5721% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.0449% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.8204% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.2682% (minimum 99%, Baseline (adaptation disabled)); colon: 80.4029% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.8182% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.9751% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.0175% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.1095% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.6991% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.8204% (minimum 99%, Baseline (adaptation disabled)); liver: 76.2153% (minimum 99%, Baseline (adaptation disabled)); lung: 72.2039% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.9168% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.5985% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.6985% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 81.9030% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.3801% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.9751% (minimum 97%, Baseline (adaptation disabled)); retina: 63.3478% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.8471% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 70.0159% (minimum 99%, Baseline (adaptation disabled)); skin: 79.5290% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.2559% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.1139% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.1095% (minimum 99%, Baseline (adaptation disabled)); spleen: 79.5290% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.8151% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.9842% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.5788% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.1145% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.0356% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,25.4,22.5,25.8,"thymus: 25.8 nTPM (manageable, limit 5); retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 2); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 2); bone marrow: 19.2 nTPM (vital, limit 1); skeletal muscle: 18.8 nTPM (vital, limit 1); thyroid gland: 18.3 nTPM (manageable, limit 5); urinary bladder: 17.9 nTPM (protected, limit 2); lung: 16.9 nTPM (vital, limit 1); cerebellum: 16.2 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); hypothalamus: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 2); rectum: 12.4 nTPM (protected, limit 2); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 2); adrenal gland: 11.4 nTPM (vital, limit 1); spleen: 11.3 nTPM (manageable, limit 5); skin: 11.3 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); pancreas: 10.5 nTPM (vital, limit 1); salivary gland: 10.4 nTPM (protected, limit 2); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 2); choroid plexus: 4.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000139496,NUP58,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.320158,-0.308855,-0.356522
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.5618% (minimum 90%, Approved); adrenal gland: 79.3852% (minimum 98%, Approved); amygdala: 81.1460% (minimum 99%, Missing); basal ganglia: 79.9636% (minimum 99%, Missing); bone marrow: 69.5721% (minimum 98%, Approved); cerebellum: 73.0449% (minimum 99%, Missing); cerebral cortex: 75.8204% (minimum 99%, Missing); choroid plexus: 91.2682% (minimum 99%, Missing); colon: 80.4029% (minimum 97%, Missing); duodenum: 79.8182% (minimum 99%, Missing); esophagus: 77.9751% (minimum 97%, Missing); heart muscle: 77.0175% (minimum 99%, Missing); hippocampal formation: 80.1095% (minimum 99%, Missing); hypothalamus: 77.6991% (minimum 99%, Missing); kidney: 75.8204% (minimum 99%, Missing); liver: 76.2153% (minimum 99%, Missing); lung: 72.2039% (minimum 99%, Missing); lymph node: 68.9168% (minimum 97%, Missing); midbrain: 81.5985% (minimum 99%, Missing); pancreas: 80.6985% (minimum 99%, Missing); parathyroid gland: 81.9030% (minimum 97%, Missing); pituitary gland: 68.3801% (minimum 99%, Missing); rectum: 77.9751% (minimum 97%, Missing); retina: 63.3478% (minimum 99%, Missing); salivary gland: 80.8471% (minimum 97%, Missing); skeletal muscle: 70.0159% (minimum 98%, Approved); skin: 79.5290% (minimum 95%, Missing); small intestine: 80.2559% (minimum 99%, Missing); smooth muscle: 78.1139% (minimum 99%, Missing); spinal cord: 80.1095% (minimum 99%, Missing); spleen: 79.5290% (minimum 95%, Missing); stomach: 78.8151% (minimum 97%, Missing); thymus: 62.9842% (minimum 95%, Missing); thyroid gland: 70.5788% (minimum 95%, Missing); tongue: 66.1145% (minimum 97%, Missing); urinary bladder: 71.0356% (minimum 97%, Missing)",0,7,partial,25.4,22.5,25.8,"thymus: 25.8 nTPM (manageable, limit 5); retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 2); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 2); bone marrow: 19.2 nTPM (vital, limit 2); skeletal muscle: 18.8 nTPM (vital, limit 2); thyroid gland: 18.3 nTPM (manageable, limit 5); urinary bladder: 17.9 nTPM (protected, limit 2); lung: 16.9 nTPM (vital, limit 1); cerebellum: 16.2 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 10); hypothalamus: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 2); rectum: 12.4 nTPM (protected, limit 2); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 2); adrenal gland: 11.4 nTPM (vital, limit 2); spleen: 11.3 nTPM (manageable, limit 5); skin: 11.3 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); pancreas: 10.5 nTPM (vital, limit 1); salivary gland: 10.4 nTPM (protected, limit 2); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 2); choroid plexus: 4.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000139496,NUP58,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.320158,-0.308855,-0.356522
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,18.9,1.4,2.5,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139537,CCDC65,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9071% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.5170% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.4141% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.2766% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1030% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.5170% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.6987% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.3469% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.4141% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.5145% (minimum 99%, Baseline (adaptation disabled)); lung: 92.8205% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.8378% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.8378% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.2766% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.5170% (minimum 99%, Baseline (adaptation disabled)); retina: 83.9907% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.6376% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.8378% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 93.5401% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,18.9,1.4,2.5,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139537,CCDC65,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0145995,-0.00723404,-0.333013
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9071% (minimum 99%, Missing); amygdala: 94.5170% (minimum 99%, Missing); basal ganglia: 91.4141% (minimum 99%, Missing); bone marrow: 96.2766% (minimum 99%, Missing); cerebellum: 98.1030% (minimum 99%, Missing); cerebral cortex: 94.5170% (minimum 99%, Missing); choroid plexus: 65.6987% (minimum 99%, Missing); hippocampal formation: 92.3469% (minimum 99%, Missing); hypothalamus: 91.4141% (minimum 99%, Missing); kidney: 95.5145% (minimum 99%, Missing); lung: 92.8205% (minimum 99%, Missing); midbrain: 97.8378% (minimum 99%, Missing); pancreas: 97.8378% (minimum 99%, Missing); parathyroid gland: 96.2766% (minimum 97%, Missing); pituitary gland: 94.5170% (minimum 99%, Missing); retina: 83.9907% (minimum 99%, Missing); small intestine: 98.6376% (minimum 99%, Missing); spinal cord: 97.8378% (minimum 99%, Missing); thyroid gland: 93.5401% (minimum 95%, Missing)",0,80,unavailable,18.9,1.4,2.5,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139537,CCDC65,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0145995,-0.00723404,-0.333013
True,compatible,,True,True,False,,0,80,unavailable,1,0.6,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000139549,DHH,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.7805% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7805% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.4286% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7805% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 97.0060% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.7805% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.4286% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.5904% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.5904% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.1860% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 96.4286% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1,0.6,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000139549,DHH,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.00294118,-0.00571429,-0.0481395
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.7805% (minimum 99%, Missing); cerebellum: 98.7805% (minimum 99%, Missing); heart muscle: 96.4286% (minimum 99%, Missing); hypothalamus: 98.7805% (minimum 99%, Missing); kidney: 96.4286% (minimum 99%, Missing); lung: 97.0060% (minimum 99%, Missing); midbrain: 98.7805% (minimum 99%, Missing); pituitary gland: 96.4286% (minimum 99%, Missing); small intestine: 97.5904% (minimum 99%, Missing); smooth muscle: 97.5904% (minimum 99%, Missing); spinal cord: 94.1860% (minimum 99%, Missing); urinary bladder: 96.4286% (minimum 97%, Missing)",0,80,unavailable,1,0.6,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000139549,DHH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.00294118,-0.00571429,-0.0481395
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.4,2.1,4.4,"bone marrow: 5.4 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139618,BRCA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.7742% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 35.7143% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.7742% (minimum 99%, Baseline (adaptation disabled)); colon: 78.9474% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.7143% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.7143% (minimum 97%, Baseline (adaptation disabled)); kidney: 96.7742% (minimum 99%, Baseline (adaptation disabled)); liver: 93.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 90.9091% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.8235% (minimum 97%, Baseline (adaptation disabled)); pancreas: 96.7742% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.0000% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 93.7500% (minimum 97%, Baseline (adaptation disabled)); skin: 81.0811% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.9091% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.0811% (minimum 97%, Baseline (adaptation disabled)); thymus: 40.5405% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.7500% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 85.7143% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.4,2.1,4.4,"bone marrow: 5.4 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139618,BRCA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.544595,-0.381765,-0.632857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Missing); adrenal gland: 96.7742% (minimum 99%, Missing); bone marrow: 35.7143% (minimum 99%, Missing); cerebral cortex: 96.7742% (minimum 99%, Missing); colon: 78.9474% (minimum 97%, Missing); duodenum: 85.7143% (minimum 99%, Missing); esophagus: 85.7143% (minimum 97%, Missing); kidney: 96.7742% (minimum 99%, Missing); liver: 93.7500% (minimum 99%, Missing); lung: 90.9091% (minimum 99%, Missing); lymph node: 58.8235% (minimum 97%, Missing); pancreas: 96.7742% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); salivary gland: 93.7500% (minimum 97%, Missing); skin: 81.0811% (minimum 95%, Missing); small intestine: 85.7143% (minimum 99%, Missing); smooth muscle: 90.9091% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 81.0811% (minimum 97%, Missing); thymus: 40.5405% (minimum 95%, Missing); thyroid gland: 93.7500% (minimum 95%, Missing); urinary bladder: 85.7143% (minimum 97%, Missing)",0,80,unavailable,5.4,2.1,4.4,"bone marrow: 5.4 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139618,BRCA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.544595,-0.381765,-0.632857
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6,2.2,1.8,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139714,MORN3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.6522% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.6923% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.6154% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.6522% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.7059% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 42.3077% (minimum 99%, Baseline (adaptation disabled)); duodenum: 95.6522% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.6522% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.7681% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.7500% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.2745% (minimum 99%, Baseline (adaptation disabled)); liver: 97.7778% (minimum 99%, Baseline (adaptation disabled)); lung: 83.0189% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.5714% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.7959% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.6170% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.5714% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.6522% (minimum 97%, Baseline (adaptation disabled)); retina: 88.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.7778% (minimum 99%, Baseline (adaptation disabled)); skin: 70.9677% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.6522% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.2745% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 83.0189% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.6522% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6,2.2,1.8,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139714,MORN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.240323,-0.303333,-0.566923
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.6522% (minimum 99%, Missing); amygdala: 67.6923% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 84.6154% (minimum 99%, Missing); cerebellum: 95.6522% (minimum 99%, Missing); cerebral cortex: 64.7059% (minimum 99%, Missing); choroid plexus: 42.3077% (minimum 99%, Missing); duodenum: 95.6522% (minimum 99%, Missing); heart muscle: 95.6522% (minimum 99%, Missing); hippocampal formation: 63.7681% (minimum 99%, Missing); hypothalamus: 68.7500% (minimum 99%, Missing); kidney: 86.2745% (minimum 99%, Missing); liver: 97.7778% (minimum 99%, Missing); lung: 83.0189% (minimum 99%, Missing); lymph node: 78.5714% (minimum 97%, Missing); midbrain: 89.7959% (minimum 99%, Missing); pancreas: 93.6170% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 78.5714% (minimum 99%, Missing); rectum: 95.6522% (minimum 97%, Missing); retina: 88.0000% (minimum 99%, Missing); salivary gland: 91.6667% (minimum 97%, Missing); skeletal muscle: 97.7778% (minimum 99%, Missing); skin: 70.9677% (minimum 95%, Missing); small intestine: 91.6667% (minimum 99%, Missing); smooth muscle: 95.6522% (minimum 99%, Missing); spinal cord: 91.6667% (minimum 99%, Missing); spleen: 86.2745% (minimum 95%, Missing); stomach: 88.0000% (minimum 97%, Missing); thymus: 83.0189% (minimum 95%, Missing); thyroid gland: 88.0000% (minimum 95%, Missing); urinary bladder: 95.6522% (minimum 97%, Missing)",0,80,unavailable,6,2.2,1.8,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139714,MORN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.240323,-0.303333,-0.566923
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.1,7.8,9.3,"retina: 10.1 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); skin: 6.7 nTPM (manageable, limit 5); colon: 6.6 nTPM (protected, limit 2); adrenal gland: 6.6 nTPM (vital, limit 1); hypothalamus: 6.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 2); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); duodenum: 5 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); heart muscle: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); kidney: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139719,VPS33A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.5659% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 55.4054% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.4203% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.1644% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 56.5517% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 52.2293% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.2500% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.9928% (minimum 99%, Baseline (adaptation disabled)); colon: 55.4054% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.1212% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.5954% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.0625% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.3427% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 56.1644% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.6000% (minimum 99%, Baseline (adaptation disabled)); liver: 58.9928% (minimum 99%, Baseline (adaptation disabled)); lung: 61.6541% (minimum 99%, Baseline (adaptation disabled)); lymph node: 51.2500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 57.7465% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.7407% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.1560% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 47.6744% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.7407% (minimum 97%, Baseline (adaptation disabled)); retina: 44.8087% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.0794% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 48.8095% (minimum 99%, Baseline (adaptation disabled)); skin: 55.0336% (minimum 95%, Baseline (adaptation disabled)); small intestine: 58.5714% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.9444% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.9444% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.2941% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.8571% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.1290% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.5714% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.6541% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.1,7.8,9.3,"retina: 10.1 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); skin: 6.7 nTPM (manageable, limit 5); colon: 6.6 nTPM (protected, limit 2); adrenal gland: 6.6 nTPM (vital, limit 1); hypothalamus: 6.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 2); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); duodenum: 5 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); heart muscle: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); kidney: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139719,VPS33A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.481429,-0.4575,-0.541913
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.5659% (minimum 95%, Missing); adrenal gland: 55.4054% (minimum 99%, Missing); amygdala: 59.4203% (minimum 99%, Missing); basal ganglia: 56.1644% (minimum 99%, Missing); bone marrow: 56.5517% (minimum 99%, Missing); cerebellum: 52.2293% (minimum 99%, Missing); cerebral cortex: 51.2500% (minimum 99%, Missing); choroid plexus: 58.9928% (minimum 99%, Missing); colon: 55.4054% (minimum 97%, Missing); duodenum: 62.1212% (minimum 99%, Missing); esophagus: 62.5954% (minimum 97%, Missing); heart muscle: 64.0625% (minimum 99%, Missing); hippocampal formation: 57.3427% (minimum 99%, Missing); hypothalamus: 56.1644% (minimum 99%, Missing); kidney: 65.6000% (minimum 99%, Missing); liver: 58.9928% (minimum 99%, Missing); lung: 61.6541% (minimum 99%, Missing); lymph node: 51.2500% (minimum 97%, Missing); midbrain: 57.7465% (minimum 99%, Missing); pancreas: 60.7407% (minimum 99%, Missing); parathyroid gland: 58.1560% (minimum 97%, Missing); pituitary gland: 47.6744% (minimum 99%, Missing); rectum: 60.7407% (minimum 97%, Missing); retina: 44.8087% (minimum 99%, Missing); salivary gland: 65.0794% (minimum 97%, Missing); skeletal muscle: 48.8095% (minimum 99%, Missing); skin: 55.0336% (minimum 95%, Missing); small intestine: 58.5714% (minimum 99%, Missing); smooth muscle: 56.9444% (minimum 99%, Missing); spinal cord: 56.9444% (minimum 99%, Missing); spleen: 54.6667% (minimum 95%, Missing); stomach: 60.2941% (minimum 97%, Missing); thymus: 46.8571% (minimum 95%, Missing); thyroid gland: 66.1290% (minimum 95%, Missing); tongue: 58.5714% (minimum 97%, Missing); urinary bladder: 61.6541% (minimum 97%, Missing)",0,80,unavailable,10.1,7.8,9.3,"retina: 10.1 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); skin: 6.7 nTPM (manageable, limit 5); colon: 6.6 nTPM (protected, limit 2); adrenal gland: 6.6 nTPM (vital, limit 1); hypothalamus: 6.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 2); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 2); duodenum: 5 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); heart muscle: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); kidney: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139719,VPS33A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.481429,-0.4575,-0.541913
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7,2.3,5.3,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); smooth muscle: 2.5 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); esophagus: 2.1 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139734,DIAPH3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.8115% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.8115% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.3320% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.8115% (minimum 99%, Baseline (adaptation disabled)); colon: 91.0448% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.0448% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.7059% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 97.3404% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.3158% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.8115% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9189% (minimum 99%, Baseline (adaptation disabled)); lung: 93.8462% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8350% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.3404% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.9189% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.1478% (minimum 97%, Baseline (adaptation disabled)); skin: 93.8462% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.9598% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.9808% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9189% (minimum 99%, Baseline (adaptation disabled)); stomach: 92.4242% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.5424% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.8254% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7,2.3,5.3,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); smooth muscle: 2.5 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); esophagus: 2.1 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139734,DIAPH3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.174576,-0.0816505,-0.26668
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.8115% (minimum 99%, Missing); basal ganglia: 95.8115% (minimum 99%, Missing); bone marrow: 72.3320% (minimum 99%, Missing); cerebral cortex: 95.8115% (minimum 99%, Missing); colon: 91.0448% (minimum 97%, Missing); duodenum: 91.0448% (minimum 99%, Missing); esophagus: 89.7059% (minimum 97%, Missing); hippocampal formation: 97.3404% (minimum 99%, Missing); hypothalamus: 96.3158% (minimum 99%, Missing); kidney: 95.8115% (minimum 99%, Missing); liver: 98.9189% (minimum 99%, Missing); lung: 93.8462% (minimum 99%, Missing); lymph node: 88.8350% (minimum 97%, Missing); midbrain: 97.3404% (minimum 99%, Missing); pancreas: 98.9189% (minimum 99%, Missing); rectum: 90.1478% (minimum 97%, Missing); skin: 93.8462% (minimum 95%, Missing); small intestine: 91.9598% (minimum 99%, Missing); smooth muscle: 87.9808% (minimum 99%, Missing); spinal cord: 98.9189% (minimum 99%, Missing); stomach: 92.4242% (minimum 97%, Missing); thymus: 77.5424% (minimum 95%, Missing); urinary bladder: 96.8254% (minimum 97%, Missing)",0,80,unavailable,7,2.3,5.3,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); smooth muscle: 2.5 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); esophagus: 2.1 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139734,DIAPH3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.174576,-0.0816505,-0.26668
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000139797,RNF113B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000139797,RNF113B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.0056427
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000139797,RNF113B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.0056427
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,27,0,0,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000139800,ZIC5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.8182% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 11.7647% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.0169% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 40.4494% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.9245% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.8182% (minimum 99%, Baseline (adaptation disabled)); midbrain: 85.7143% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.7368% (minimum 99%, Baseline (adaptation disabled)); retina: 52.1739% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.5957% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,27,0,0,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000139800,ZIC5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.872353
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 99%, Missing); basal ganglia: 81.8182% (minimum 99%, Missing); cerebellum: 11.7647% (minimum 99%, Missing); cerebral cortex: 61.0169% (minimum 99%, Missing); choroid plexus: 40.4494% (minimum 99%, Missing); hippocampal formation: 67.9245% (minimum 99%, Missing); hypothalamus: 81.8182% (minimum 99%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pituitary gland: 94.7368% (minimum 99%, Missing); retina: 52.1739% (minimum 99%, Missing); spinal cord: 76.5957% (minimum 99%, Missing)",0,80,unavailable,27,0,0,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000139800,ZIC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.872353
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.7,1.3,5.7,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139890,REM2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.0370% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.1569% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.3846% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 38.5246% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 32.6389% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.8421% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.8065% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 79.6610% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.0370% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.1569% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.0492% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.3077% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.6032% (minimum 99%, Baseline (adaptation disabled)); liver: 88.6792% (minimum 99%, Baseline (adaptation disabled)); lung: 68.1159% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.9286% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.1569% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.3846% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 45.6311% (minimum 99%, Baseline (adaptation disabled)); retina: 90.3846% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.4545% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.4545% (minimum 99%, Baseline (adaptation disabled)); skin: 69.1176% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.1493% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.9184% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.6792% (minimum 99%, Baseline (adaptation disabled)); spleen: 45.1923% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.4545% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.6792% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.4561% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.4561% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.7,1.3,5.7,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139890,REM2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.498077,-0.186667,-0.663611
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.0370% (minimum 95%, Missing); adrenal gland: 92.1569% (minimum 99%, Missing); amygdala: 90.3846% (minimum 99%, Missing); basal ganglia: 38.5246% (minimum 99%, Missing); bone marrow: 32.6389% (minimum 99%, Missing); cerebellum: 61.8421% (minimum 99%, Missing); cerebral cortex: 75.8065% (minimum 99%, Missing); choroid plexus: 78.3333% (minimum 99%, Missing); colon: 79.6610% (minimum 97%, Missing); duodenum: 94.0000% (minimum 99%, Missing); esophagus: 87.0370% (minimum 97%, Missing); heart muscle: 92.1569% (minimum 99%, Missing); hippocampal formation: 77.0492% (minimum 99%, Missing); hypothalamus: 72.3077% (minimum 99%, Missing); kidney: 74.6032% (minimum 99%, Missing); liver: 88.6792% (minimum 99%, Missing); lung: 68.1159% (minimum 99%, Missing); lymph node: 83.9286% (minimum 97%, Missing); midbrain: 92.1569% (minimum 99%, Missing); pancreas: 90.3846% (minimum 99%, Missing); parathyroid gland: 78.3333% (minimum 97%, Missing); pituitary gland: 45.6311% (minimum 99%, Missing); retina: 90.3846% (minimum 99%, Missing); salivary gland: 85.4545% (minimum 97%, Missing); skeletal muscle: 85.4545% (minimum 99%, Missing); skin: 69.1176% (minimum 95%, Missing); small intestine: 70.1493% (minimum 99%, Missing); smooth muscle: 95.9184% (minimum 99%, Missing); spinal cord: 88.6792% (minimum 99%, Missing); spleen: 45.1923% (minimum 95%, Missing); stomach: 85.4545% (minimum 97%, Missing); thymus: 88.6792% (minimum 95%, Missing); thyroid gland: 82.4561% (minimum 95%, Missing); tongue: 94.0000% (minimum 97%, Missing); urinary bladder: 82.4561% (minimum 97%, Missing)",0,80,unavailable,9.7,1.3,5.7,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000139890,REM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.498077,-0.186667,-0.663611
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,4.3,0.2,0.3,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,51,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000139915,MDGA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.8718% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.7234% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.2222% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.8718% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.3889% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.8718% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.4348% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.3684% (minimum 99%, Baseline (adaptation disabled)); liver: 97.3684% (minimum 99%, Baseline (adaptation disabled)); midbrain: 84.0909% (minimum 99%, Baseline (adaptation disabled)); retina: 46.2500% (minimum 99%, Baseline (adaptation disabled)); skin: 92.5000% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 68.5185% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.8718% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,4.3,0.2,0.3,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,51,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000139915,MDGA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.025,-0.0212821,-0.5275
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.8718% (minimum 99%, Uncertain); amygdala: 78.7234% (minimum 99%, Missing); basal ganglia: 82.2222% (minimum 99%, Missing); cerebellum: 94.8718% (minimum 99%, Uncertain); cerebral cortex: 51.3889% (minimum 99%, Uncertain); choroid plexus: 94.8718% (minimum 99%, Missing); hippocampal formation: 80.4348% (minimum 99%, Missing); hypothalamus: 74.0000% (minimum 99%, Missing); kidney: 97.3684% (minimum 99%, Uncertain); liver: 97.3684% (minimum 99%, Uncertain); midbrain: 84.0909% (minimum 99%, Missing); retina: 46.2500% (minimum 99%, Missing); skin: 92.5000% (minimum 95%, Uncertain); spinal cord: 68.5185% (minimum 99%, Missing); stomach: 94.8718% (minimum 97%, Uncertain)",0,4,partial,4.3,0.2,0.3,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,51,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000139915,MDGA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.025,-0.0212821,-0.5275
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,11,11,9.8,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 2); tongue: 7 nTPM (protected, limit 2); rectum: 6.5 nTPM (protected, limit 2); urinary bladder: 6.4 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); colon: 5.9 nTPM (protected, limit 2); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); esophagus: 5.1 nTPM (protected, limit 2); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000140006,WDR89,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2047% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.0882% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.2893% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.7541% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.4771% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 58.0882% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.7692% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.5283% (minimum 99%, Baseline (adaptation disabled)); colon: 57.2464% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.7188% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.7692% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.2893% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.8333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.8333% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.1707% (minimum 99%, Baseline (adaptation disabled)); liver: 48.1707% (minimum 99%, Baseline (adaptation disabled)); lung: 59.8485% (minimum 99%, Baseline (adaptation disabled)); lymph node: 41.7989% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.6957% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.0882% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.3179% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.4771% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.8611% (minimum 97%, Baseline (adaptation disabled)); retina: 41.7989% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.9492% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.5185% (minimum 99%, Baseline (adaptation disabled)); skin: 56.8345% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.9492% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.7692% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.2276% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.4663% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.8485% (minimum 97%, Baseline (adaptation disabled)); thymus: 44.6328% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 47.0238% (minimum 95%, Baseline (adaptation disabled)); tongue: 53.0201% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.2448% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,11,11,9.8,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 2); tongue: 7 nTPM (protected, limit 2); rectum: 6.5 nTPM (protected, limit 2); urinary bladder: 6.4 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); colon: 5.9 nTPM (protected, limit 2); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); esophagus: 5.1 nTPM (protected, limit 2); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000140006,WDR89,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.503672,-0.552011,-0.572011
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2047% (minimum 95%, Uncertain); adrenal gland: 58.0882% (minimum 99%, Missing); amygdala: 65.2893% (minimum 99%, Missing); basal ganglia: 64.7541% (minimum 99%, Missing); bone marrow: 72.4771% (minimum 99%, Uncertain); cerebellum: 58.0882% (minimum 99%, Uncertain); cerebral cortex: 60.7692% (minimum 99%, Missing); choroid plexus: 74.5283% (minimum 99%, Missing); colon: 57.2464% (minimum 97%, Missing); duodenum: 61.7188% (minimum 99%, Missing); esophagus: 60.7692% (minimum 97%, Uncertain); heart muscle: 65.2893% (minimum 99%, Uncertain); hippocampal formation: 65.8333% (minimum 99%, Missing); hypothalamus: 65.8333% (minimum 99%, Missing); kidney: 48.1707% (minimum 99%, Missing); liver: 48.1707% (minimum 99%, Missing); lung: 59.8485% (minimum 99%, Missing); lymph node: 41.7989% (minimum 97%, Missing); midbrain: 68.6957% (minimum 99%, Missing); pancreas: 58.0882% (minimum 99%, Missing); parathyroid gland: 52.3179% (minimum 97%, Missing); pituitary gland: 72.4771% (minimum 99%, Missing); rectum: 54.8611% (minimum 97%, Missing); retina: 41.7989% (minimum 99%, Missing); salivary gland: 66.9492% (minimum 97%, Missing); skeletal muscle: 58.5185% (minimum 99%, Uncertain); skin: 56.8345% (minimum 95%, Uncertain); small intestine: 66.9492% (minimum 99%, Missing); smooth muscle: 60.7692% (minimum 99%, Uncertain); spinal cord: 64.2276% (minimum 99%, Missing); spleen: 48.4663% (minimum 95%, Uncertain); stomach: 59.8485% (minimum 97%, Missing); thymus: 44.6328% (minimum 95%, Missing); thyroid gland: 47.0238% (minimum 95%, Missing); tongue: 53.0201% (minimum 97%, Missing); urinary bladder: 55.2448% (minimum 97%, Missing)",0,4,partial,11,11,9.8,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 2); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 2); tongue: 7 nTPM (protected, limit 2); rectum: 6.5 nTPM (protected, limit 2); urinary bladder: 6.4 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); colon: 5.9 nTPM (protected, limit 2); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); esophagus: 5.1 nTPM (protected, limit 2); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000140006,WDR89,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.503672,-0.552011,-0.572011
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,5.9,2,2.4,"adrenal gland: 5.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140009,ESR2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 79.7101% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 48.2456% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.2143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.4912% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.9375% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.7097% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.8276% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.2143% (minimum 99%, Baseline (adaptation disabled)); colon: 87.3016% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.9375% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.7097% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.1639% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.8276% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.7101% (minimum 99%, Baseline (adaptation disabled)); liver: 88.7097% (minimum 99%, Baseline (adaptation disabled)); lung: 90.1639% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.2143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.3333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 88.7097% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.9375% (minimum 97%, Baseline (adaptation disabled)); retina: 75.3425% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.3016% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.8824% (minimum 99%, Baseline (adaptation disabled)); skin: 85.9375% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.0896% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.8276% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2143% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.3889% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.9375% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.6203% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.1639% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.4912% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.3333% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,5.9,2,2.4,"adrenal gland: 5.9 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140009,ESR2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.253797,-0.236667,-0.507544
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.2456% (minimum 99%, Missing); amygdala: 98.2143% (minimum 99%, Missing); basal ganglia: 96.4912% (minimum 99%, Missing); bone marrow: 85.9375% (minimum 95%, Enhanced); cerebellum: 88.7097% (minimum 95%, Enhanced); cerebral cortex: 94.8276% (minimum 95%, Enhanced); choroid plexus: 98.2143% (minimum 99%, Missing); duodenum: 85.9375% (minimum 95%, Enhanced); heart muscle: 90.1639% (minimum 95%, Enhanced); hippocampal formation: 98.2143% (minimum 99%, Missing); hypothalamus: 94.8276% (minimum 99%, Missing); kidney: 79.7101% (minimum 95%, Enhanced); liver: 88.7097% (minimum 95%, Enhanced); lung: 90.1639% (minimum 95%, Enhanced); lymph node: 73.3333% (minimum 97%, Missing); midbrain: 98.2143% (minimum 99%, Missing); pancreas: 73.3333% (minimum 95%, Enhanced); pituitary gland: 88.7097% (minimum 99%, Missing); rectum: 85.9375% (minimum 97%, Missing); retina: 75.3425% (minimum 99%, Missing); skeletal muscle: 80.8824% (minimum 95%, Enhanced); small intestine: 82.0896% (minimum 95%, Enhanced); smooth muscle: 94.8276% (minimum 95%, Enhanced); spinal cord: 98.2143% (minimum 99%, Missing); thymus: 69.6203% (minimum 95%, Missing); tongue: 96.4912% (minimum 97%, Missing)",0,2,partial,5.9,2,2.4,"adrenal gland: 5.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140009,ESR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.253797,-0.236667,-0.507544
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,4.3,0,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000140015,KCNH5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 60.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 23.0769% (minimum 99%, Baseline (adaptation disabled)); amygdala: 33.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 11.5385% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 37.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 23.0769% (minimum 99%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 6.5217% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 60.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,4.3,0,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000140015,KCNH5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.35,0.03,-0.924783
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 60.0000% (minimum 95%, Missing); adrenal gland: 23.0769% (minimum 99%, Missing); amygdala: 33.3333% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); cerebral cortex: 11.5385% (minimum 99%, Missing); choroid plexus: 37.5000% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 23.0769% (minimum 99%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pituitary gland: 50.0000% (minimum 99%, Missing); retina: 6.5217% (minimum 99%, Missing); spinal cord: 60.0000% (minimum 99%, Missing)",0,80,unavailable,4.3,0,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000140015,KCNH5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.35,0.03,-0.924783
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.6,7.9,7.6,"parathyroid gland: 7.9 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); urinary bladder: 4.5 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140025,EFCAB11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.1481% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.9244% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.4480% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.8173% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.4444% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.9310% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.6505% (minimum 99%, Baseline (adaptation disabled)); colon: 87.2861% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.9310% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.3663% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.4555% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.8173% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.7150% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.0233% (minimum 99%, Baseline (adaptation disabled)); liver: 86.0241% (minimum 99%, Baseline (adaptation disabled)); lung: 92.2481% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.8397% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.8306% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.3663% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 81.8807% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.7738% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.0732% (minimum 97%, Baseline (adaptation disabled)); retina: 85.6115% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.5856% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.9468% (minimum 99%, Baseline (adaptation disabled)); skin: 92.0103% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.6091% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.6091% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.3972% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.3043% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.0274% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.4737% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.4480% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.9474% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.8060% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7.6,7.9,7.6,"parathyroid gland: 7.9 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); urinary bladder: 4.5 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140025,EFCAB11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.12552,-0.151193,-0.16552
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.1481% (minimum 95%, Missing); adrenal gland: 89.9244% (minimum 99%, Missing); amygdala: 82.4480% (minimum 99%, Missing); basal ganglia: 85.0000% (minimum 99%, Missing); bone marrow: 85.8173% (minimum 99%, Missing); cerebellum: 94.4444% (minimum 99%, Missing); cerebral cortex: 87.9310% (minimum 99%, Missing); choroid plexus: 86.6505% (minimum 99%, Missing); colon: 87.2861% (minimum 97%, Missing); duodenum: 87.9310% (minimum 99%, Missing); esophagus: 88.3663% (minimum 97%, Missing); heart muscle: 93.4555% (minimum 99%, Missing); hippocampal formation: 85.8173% (minimum 99%, Missing); hypothalamus: 87.7150% (minimum 99%, Missing); kidney: 83.0233% (minimum 99%, Missing); liver: 86.0241% (minimum 99%, Missing); lung: 92.2481% (minimum 99%, Missing); lymph node: 90.8397% (minimum 97%, Missing); midbrain: 82.8306% (minimum 99%, Missing); pancreas: 88.3663% (minimum 99%, Missing); parathyroid gland: 81.8807% (minimum 97%, Missing); pituitary gland: 91.7738% (minimum 99%, Missing); rectum: 87.0732% (minimum 97%, Missing); retina: 85.6115% (minimum 99%, Missing); salivary gland: 88.5856% (minimum 97%, Missing); skeletal muscle: 94.9468% (minimum 99%, Missing); skin: 92.0103% (minimum 95%, Missing); small intestine: 90.6091% (minimum 99%, Missing); smooth muscle: 90.6091% (minimum 99%, Missing); spinal cord: 84.3972% (minimum 99%, Missing); spleen: 91.3043% (minimum 95%, Missing); stomach: 89.0274% (minimum 97%, Missing); thymus: 89.4737% (minimum 95%, Missing); thyroid gland: 82.4480% (minimum 95%, Missing); tongue: 93.9474% (minimum 97%, Missing); urinary bladder: 88.8060% (minimum 97%, Missing)",0,80,unavailable,7.6,7.9,7.6,"parathyroid gland: 7.9 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); urinary bladder: 4.5 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140025,EFCAB11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.12552,-0.151193,-0.16552
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,31.7,31.1,12.3,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 2); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (manageable, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 2); skin: 6.8 nTPM (manageable, limit 5); salivary gland: 6.6 nTPM (protected, limit 2); stomach: 6.1 nTPM (protected, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 4); urinary bladder: 4.1 nTPM (protected, limit 2); lymph node: 3 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140043,PTGR2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4894% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.7413% (minimum 99%, Baseline (adaptation disabled)); amygdala: 55.6291% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.2632% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.1098% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.3363% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.3379% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 50.9091% (minimum 99%, Baseline (adaptation disabled)); colon: 70.5882% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.7413% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.7778% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 38.8889% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 59.7865% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.2151% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 47.5921% (minimum 99%, Baseline (adaptation disabled)); lung: 75.6757% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.8485% (minimum 97%, Baseline (adaptation disabled)); midbrain: 53.5032% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.7123% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.2222% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.4215% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.3363% (minimum 97%, Baseline (adaptation disabled)); retina: 61.5385% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.7949% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 34.6392% (minimum 99%, Baseline (adaptation disabled)); skin: 71.1864% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.8824% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.0466% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.5342% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.5821% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.3624% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.2792% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.7320% (minimum 95%, Baseline (adaptation disabled)); tongue: 35.0731% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.3828% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,31.7,31.1,12.3,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 2); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (manageable, limit 5); duodenum: 11.8 nTPM (vital, limit 1); adrenal gland: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 2); skin: 6.8 nTPM (manageable, limit 5); adipose tissue: 6.7 nTPM (manageable, limit 5); salivary gland: 6.6 nTPM (protected, limit 2); stomach: 6.1 nTPM (protected, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); lymph node: 3 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140043,PTGR2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.37268,-0.619269,-0.643608
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4894% (minimum 90%, Approved); adrenal gland: 58.7413% (minimum 99%, Missing); amygdala: 55.6291% (minimum 99%, Missing); basal ganglia: 55.2632% (minimum 99%, Missing); bone marrow: 97.1098% (minimum 98%, Approved); cerebellum: 74.3363% (minimum 99%, Missing); cerebral cortex: 57.3379% (minimum 99%, Missing); choroid plexus: 50.9091% (minimum 99%, Missing); colon: 70.5882% (minimum 97%, Missing); duodenum: 58.7413% (minimum 99%, Missing); esophagus: 77.7778% (minimum 95%, Approved); heart muscle: 38.8889% (minimum 99%, Missing); hippocampal formation: 59.7865% (minimum 99%, Missing); hypothalamus: 60.2151% (minimum 99%, Missing); kidney: 48.0000% (minimum 99%, Missing); liver: 47.5921% (minimum 99%, Missing); lung: 75.6757% (minimum 99%, Missing); lymph node: 84.8485% (minimum 97%, Missing); midbrain: 53.5032% (minimum 99%, Missing); pancreas: 76.7123% (minimum 99%, Missing); parathyroid gland: 62.2222% (minimum 97%, Missing); pituitary gland: 69.4215% (minimum 99%, Missing); rectum: 75.3363% (minimum 97%, Missing); retina: 61.5385% (minimum 99%, Missing); salivary gland: 71.7949% (minimum 97%, Missing); skeletal muscle: 34.6392% (minimum 99%, Missing); skin: 71.1864% (minimum 95%, Missing); small intestine: 65.8824% (minimum 99%, Missing); smooth muscle: 87.0466% (minimum 98%, Approved); spinal cord: 57.5342% (minimum 99%, Missing); spleen: 83.5821% (minimum 95%, Missing); stomach: 73.3624% (minimum 97%, Missing); thymus: 85.2792% (minimum 95%, Missing); thyroid gland: 57.7320% (minimum 95%, Missing); tongue: 35.0731% (minimum 97%, Missing); urinary bladder: 80.3828% (minimum 97%, Missing)",0,4,partial,31.7,31.1,12.3,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 2); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (manageable, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 2); skin: 6.8 nTPM (manageable, limit 5); salivary gland: 6.6 nTPM (protected, limit 2); stomach: 6.1 nTPM (protected, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 4); urinary bladder: 4.1 nTPM (protected, limit 2); lymph node: 3 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140043,PTGR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.37268,-0.619269,-0.643608
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,13,partial,17.7,6.7,5.4,"choroid plexus: 17.7 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000140057,AK7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.7336% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.1569% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.7664% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.3775% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7395% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.3775% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 57.0388% (minimum 99%, Baseline (adaptation disabled)); colon: 92.1569% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.8854% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.1074% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.7159% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.5972% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.5324% (minimum 99%, Baseline (adaptation disabled)); liver: 94.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 85.7664% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.1417% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.7969% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.8146% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.4561% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 89.3536% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.3115% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.7395% (minimum 99%, Baseline (adaptation disabled)); skin: 81.3149% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.1417% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.3115% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.6255% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.0150% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.0383% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 90.3846% (minimum 95%, Baseline (adaptation disabled))",0,13,partial,17.7,6.7,5.4,"choroid plexus: 17.7 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 2); skin: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000140057,AK7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.136851,-0.191854,-0.419612
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.7336% (minimum 95%, Enhanced); amygdala: 92.1569% (minimum 99%, Missing); basal ganglia: 85.7664% (minimum 99%, Missing); bone marrow: 94.3775% (minimum 95%, Enhanced); cerebral cortex: 94.3775% (minimum 95%, Enhanced); choroid plexus: 57.0388% (minimum 99%, Missing); colon: 92.1569% (minimum 97%, Missing); duodenum: 92.8854% (minimum 99%, Missing); hippocampal formation: 86.7159% (minimum 99%, Missing); hypothalamus: 81.5972% (minimum 99%, Missing); kidney: 84.5324% (minimum 99%, Missing); liver: 94.0000% (minimum 95%, Enhanced); lung: 85.7664% (minimum 99%, Missing); midbrain: 95.1417% (minimum 99%, Missing); pancreas: 91.7969% (minimum 99%, Missing); parathyroid gland: 77.8146% (minimum 80%, Enhanced); pituitary gland: 82.4561% (minimum 99%, Missing); rectum: 94.0000% (minimum 97%, Missing); retina: 89.3536% (minimum 99%, Missing); small intestine: 95.1417% (minimum 99%, Missing); spinal cord: 93.6255% (minimum 99%, Missing); spleen: 88.0150% (minimum 95%, Missing); stomach: 90.0383% (minimum 97%, Missing)",0,13,partial,17.7,6.7,5.4,"choroid plexus: 17.7 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000140057,AK7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.0698502,-0.0696169,-0.419612
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,13.5,0,1.1,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 6); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,ENSG00000140067,FAM181A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 70.0665% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.1446% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.0663% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.8111% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.0476% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.0247% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.4510% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5309% (minimum 99%, Baseline (adaptation disabled)); midbrain: 79.5970% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.4911% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 92.1283% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.7778% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,13.5,0,1.1,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,ENSG00000140067,FAM181A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0163609,0.03,-0.289335
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 70.0665% (minimum 99%, Missing); basal ganglia: 76.1446% (minimum 99%, Missing); cerebellum: 91.0663% (minimum 95%, Enhanced); cerebral cortex: 72.8111% (minimum 95%, Enhanced); choroid plexus: 94.0476% (minimum 99%, Missing); hippocampal formation: 78.0247% (minimum 99%, Missing); hypothalamus: 77.4510% (minimum 99%, Missing); midbrain: 79.5970% (minimum 99%, Missing); pituitary gland: 93.4911% (minimum 99%, Missing); skeletal muscle: 92.1283% (minimum 95%, Enhanced); spinal cord: 87.7778% (minimum 99%, Missing)",0,2,partial,13.5,0,1.1,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 6); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,ENSG00000140067,FAM181A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.289335
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,44.8,1.1,2.6,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140090,SLC24A4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 25.6410% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 20.4082% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 22.2222% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 17.5439% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 2.1834% (minimum 99%, Baseline (adaptation disabled)); colon: 83.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.9091% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 35.7143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 32.2581% (minimum 99%, Baseline (adaptation disabled)); liver: 90.9091% (minimum 99%, Baseline (adaptation disabled)); lung: 58.8235% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.6190% (minimum 97%, Baseline (adaptation disabled)); midbrain: 16.3934% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.9091% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 43.4783% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 7.6923% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.5556% (minimum 99%, Baseline (adaptation disabled)); skin: 90.9091% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.9231% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 30.3030% (minimum 99%, Baseline (adaptation disabled)); spleen: 27.7778% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.9091% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.4286% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.9091% (minimum 95%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.9231% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,44.8,1.1,2.6,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140090,SLC24A4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.672222,-0.49381,-0.968166
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 25.6410% (minimum 99%, Missing); basal ganglia: 20.4082% (minimum 99%, Missing); bone marrow: 22.2222% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 17.5439% (minimum 99%, Missing); choroid plexus: 2.1834% (minimum 99%, Missing); colon: 83.3333% (minimum 97%, Missing); duodenum: 83.3333% (minimum 99%, Missing); esophagus: 90.9091% (minimum 97%, Missing); heart muscle: 83.3333% (minimum 99%, Missing); hippocampal formation: 35.7143% (minimum 99%, Missing); hypothalamus: 32.2581% (minimum 99%, Missing); liver: 90.9091% (minimum 99%, Missing); lung: 58.8235% (minimum 99%, Missing); lymph node: 47.6190% (minimum 97%, Missing); midbrain: 16.3934% (minimum 99%, Missing); pancreas: 90.9091% (minimum 99%, Missing); pituitary gland: 43.4783% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 7.6923% (minimum 99%, Missing); salivary gland: 90.9091% (minimum 97%, Missing); skeletal muscle: 55.5556% (minimum 99%, Missing); skin: 90.9091% (minimum 95%, Missing); small intestine: 76.9231% (minimum 99%, Missing); smooth muscle: 71.4286% (minimum 99%, Missing); spinal cord: 30.3030% (minimum 99%, Missing); spleen: 27.7778% (minimum 95%, Missing); stomach: 90.9091% (minimum 97%, Missing); thymus: 71.4286% (minimum 95%, Missing); thyroid gland: 90.9091% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 76.9231% (minimum 97%, Missing)",0,80,unavailable,44.8,1.1,2.6,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140090,SLC24A4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.672222,-0.49381,-0.968166
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,30.1,18.3,15.1,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 2); kidney: 15.3 nTPM (vital, limit 1); thymus: 15.1 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); tongue: 10.5 nTPM (protected, limit 2); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 2); lung: 8.8 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 2); cerebellum: 7.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); salivary gland: 6.2 nTPM (protected, limit 2); adipose tissue: 6.2 nTPM (manageable, limit 5); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140199,SLC12A6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.1917% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.5517% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.7074% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.4375% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.6434% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.5244% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.6024% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.6058% (minimum 99%, Baseline (adaptation disabled)); colon: 82.5658% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.9503% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.8341% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.9503% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.4304% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.4304% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.1287% (minimum 99%, Baseline (adaptation disabled)); liver: 86.8512% (minimum 99%, Baseline (adaptation disabled)); lung: 74.0413% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.9198% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.1931% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.0702% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.3238% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.0261% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.9677% (minimum 97%, Baseline (adaptation disabled)); retina: 45.4710% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.1917% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.1048% (minimum 99%, Baseline (adaptation disabled)); skin: 76.9939% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.0413% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.2282% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.7024% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.7553% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.4304% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.4378% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 74.2604% (minimum 95%, Baseline (adaptation disabled)); tongue: 70.5056% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.8308% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,30.1,18.3,15.1,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 2); kidney: 15.3 nTPM (vital, limit 1); thymus: 15.1 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); tongue: 10.5 nTPM (protected, limit 2); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 2); lung: 8.8 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 2); cerebellum: 7.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); salivary gland: 6.2 nTPM (protected, limit 2); adipose tissue: 6.2 nTPM (manageable, limit 5); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140199,SLC12A6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.325622,-0.391659,-0.53529
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.1917% (minimum 95%, Uncertain); adrenal gland: 86.5517% (minimum 99%, Missing); amygdala: 80.7074% (minimum 99%, Missing); basal ganglia: 78.4375% (minimum 99%, Missing); bone marrow: 48.6434% (minimum 99%, Missing); cerebellum: 76.5244% (minimum 99%, Uncertain); cerebral cortex: 75.6024% (minimum 99%, Missing); choroid plexus: 91.6058% (minimum 99%, Missing); colon: 82.5658% (minimum 97%, Missing); duodenum: 77.9503% (minimum 99%, Missing); esophagus: 57.8341% (minimum 97%, Uncertain); heart muscle: 77.9503% (minimum 99%, Uncertain); hippocampal formation: 79.4304% (minimum 99%, Missing); hypothalamus: 79.4304% (minimum 99%, Missing); kidney: 62.1287% (minimum 99%, Uncertain); liver: 86.8512% (minimum 99%, Uncertain); lung: 74.0413% (minimum 99%, Missing); lymph node: 71.9198% (minimum 97%, Missing); midbrain: 78.1931% (minimum 99%, Missing); pancreas: 88.0702% (minimum 99%, Missing); parathyroid gland: 89.3238% (minimum 97%, Uncertain); pituitary gland: 82.0261% (minimum 99%, Missing); rectum: 80.9677% (minimum 97%, Missing); retina: 45.4710% (minimum 99%, Missing); salivary gland: 80.1917% (minimum 97%, Missing); skeletal muscle: 71.1048% (minimum 99%, Uncertain); skin: 76.9939% (minimum 95%, Uncertain); small intestine: 74.0413% (minimum 99%, Missing); smooth muscle: 84.2282% (minimum 99%, Uncertain); spinal cord: 74.7024% (minimum 99%, Missing); spleen: 66.7553% (minimum 95%, Uncertain); stomach: 79.4304% (minimum 97%, Missing); thymus: 62.4378% (minimum 95%, Missing); thyroid gland: 74.2604% (minimum 95%, Missing); tongue: 70.5056% (minimum 97%, Missing); urinary bladder: 75.8308% (minimum 97%, Missing)",0,3,partial,30.1,18.3,15.1,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 2); kidney: 15.3 nTPM (vital, limit 1); thymus: 15.1 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); tongue: 10.5 nTPM (protected, limit 2); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 2); lung: 8.8 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 2); cerebellum: 7.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 2); salivary gland: 6.2 nTPM (protected, limit 2); adipose tissue: 6.2 nTPM (manageable, limit 5); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 2); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140199,SLC12A6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.325622,-0.391659,-0.53529
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.4,2.5,10.4,"thymus: 10.4 nTPM (manageable, limit 5); liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140470,ADAMTS17,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.4118% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.0526% (minimum 99%, Baseline (adaptation disabled)); amygdala: 57.4468% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.8182% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.7907% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 56.2500% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.3750% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.4468% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.2308% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.8537% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.9730% (minimum 99%, Baseline (adaptation disabled)); liver: 26.7327% (minimum 99%, Baseline (adaptation disabled)); lung: 65.8537% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.3750% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.1429% (minimum 99%, Baseline (adaptation disabled)); pancreas: 36.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.1034% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.2308% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.0968% (minimum 97%, Baseline (adaptation disabled)); retina: 79.4118% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.9231% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 33.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 56.2500% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.0526% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.3750% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.8182% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.9730% (minimum 97%, Baseline (adaptation disabled)); thymus: 20.6107% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 79.4118% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.4286% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.7907% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7.4,2.5,10.4,"thymus: 10.4 nTPM (manageable, limit 5); liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140470,ADAMTS17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.743893,-0.450769,-0.722673
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.4118% (minimum 95%, Missing); adrenal gland: 71.0526% (minimum 99%, Missing); amygdala: 57.4468% (minimum 99%, Missing); basal ganglia: 60.0000% (minimum 99%, Missing); bone marrow: 81.8182% (minimum 99%, Missing); cerebellum: 90.0000% (minimum 99%, Missing); cerebral cortex: 62.7907% (minimum 99%, Missing); choroid plexus: 56.2500% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 84.3750% (minimum 99%, Missing); esophagus: 57.4468% (minimum 97%, Missing); heart muscle: 69.2308% (minimum 99%, Missing); hippocampal formation: 65.8537% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 72.9730% (minimum 99%, Missing); liver: 26.7327% (minimum 99%, Missing); lung: 65.8537% (minimum 99%, Missing); lymph node: 84.3750% (minimum 97%, Missing); midbrain: 77.1429% (minimum 99%, Missing); pancreas: 36.0000% (minimum 99%, Missing); parathyroid gland: 93.1034% (minimum 97%, Missing); pituitary gland: 69.2308% (minimum 99%, Missing); rectum: 87.0968% (minimum 97%, Missing); retina: 79.4118% (minimum 99%, Missing); salivary gland: 51.9231% (minimum 97%, Missing); skeletal muscle: 33.3333% (minimum 99%, Missing); skin: 56.2500% (minimum 95%, Missing); small intestine: 71.0526% (minimum 99%, Missing); smooth muscle: 84.3750% (minimum 99%, Missing); spinal cord: 81.8182% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 72.9730% (minimum 97%, Missing); thymus: 20.6107% (minimum 95%, Missing); thyroid gland: 79.4118% (minimum 95%, Missing); tongue: 96.4286% (minimum 97%, Missing); urinary bladder: 62.7907% (minimum 97%, Missing)",0,80,unavailable,7.4,2.5,10.4,"thymus: 10.4 nTPM (manageable, limit 5); liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140470,ADAMTS17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.743893,-0.450769,-0.722673
True,compatible,,True,True,False,,0,1,partial,0.7,0,0,,,53,not_established,not_triggered,,,ENSG00000140478,GOLGA6D,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 94.3548% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.3193% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.7,0,0,,,53,not_established,not_triggered,,,ENSG00000140478,GOLGA6D,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0464516
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 94.3548% (minimum 97%, Supported)",0,1,partial,0.7,0,0,,,53,not_established,not_triggered,,,ENSG00000140478,GOLGA6D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0264516
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.8,0.5,1.7,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140527,WDR93,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 94.9153% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.0569% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.3913% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.9153% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2456% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.2222% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 91.0569% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.5620% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.5620% (minimum 99%, Baseline (adaptation disabled)); lung: 92.5620% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2456% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.9153% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.7265% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); retina: 80.5755% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.3913% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2456% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 86.8217% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,6.8,0.5,1.7,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140527,WDR93,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0817829,-0.012735,-0.367778
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 94.9153% (minimum 99%, Missing); basal ganglia: 91.0569% (minimum 99%, Missing); bone marrow: 97.3913% (minimum 99%, Missing); cerebellum: 94.9153% (minimum 99%, Missing); cerebral cortex: 98.2456% (minimum 99%, Missing); choroid plexus: 62.2222% (minimum 99%, Missing); heart muscle: 91.0569% (minimum 99%, Missing); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 92.5620% (minimum 99%, Missing); kidney: 92.5620% (minimum 99%, Missing); lung: 92.5620% (minimum 99%, Missing); midbrain: 98.2456% (minimum 99%, Missing); pancreas: 94.9153% (minimum 99%, Missing); parathyroid gland: 95.7265% (minimum 97%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); retina: 80.5755% (minimum 99%, Missing); skeletal muscle: 97.3913% (minimum 99%, Missing); spinal cord: 98.2456% (minimum 99%, Missing); thyroid gland: 86.8217% (minimum 95%, Missing)",0,80,unavailable,6.8,0.5,1.7,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140527,WDR93,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0817829,-0.012735,-0.367778
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.4,4.1,4,"esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140534,TICRR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 82.3529% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 29.1667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 63.6364% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 25.4545% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 87.5000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.3333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 93.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.6842% (minimum 97%, Baseline (adaptation disabled)); skin: 73.6842% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.8696% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.6842% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.7778% (minimum 97%, Baseline (adaptation disabled)); thymus: 25.9259% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.3333% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 82.3529% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.4,4.1,4,"esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140534,TICRR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.690741,-0.715455,-0.698333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 82.3529% (minimum 95%, Missing); adrenal gland: 93.3333% (minimum 99%, Missing); amygdala: 93.3333% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); bone marrow: 29.1667% (minimum 99%, Missing); cerebral cortex: 87.5000% (minimum 99%, Missing); colon: 63.6364% (minimum 97%, Missing); duodenum: 58.3333% (minimum 99%, Missing); esophagus: 25.4545% (minimum 97%, Missing); heart muscle: 93.3333% (minimum 99%, Missing); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 93.3333% (minimum 99%, Missing); kidney: 93.3333% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); lung: 87.5000% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 93.3333% (minimum 99%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); rectum: 56.0000% (minimum 97%, Missing); retina: 93.3333% (minimum 99%, Missing); salivary gland: 73.6842% (minimum 97%, Missing); skin: 73.6842% (minimum 95%, Missing); small intestine: 60.8696% (minimum 99%, Missing); smooth muscle: 87.5000% (minimum 99%, Missing); spleen: 73.6842% (minimum 95%, Missing); stomach: 77.7778% (minimum 97%, Missing); thymus: 25.9259% (minimum 95%, Missing); thyroid gland: 93.3333% (minimum 95%, Missing); urinary bladder: 82.3529% (minimum 97%, Missing)",0,80,unavailable,3.4,4.1,4,"esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000140534,TICRR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.690741,-0.715455,-0.698333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.1,0,0,"cerebellum: 3.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000140623,SEPTIN12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 96.8750% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.1,0,0,"cerebellum: 3.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000140623,SEPTIN12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.02125
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 96.8750% (minimum 99%, Missing)",0,80,unavailable,3.1,0,0,"cerebellum: 3.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000140623,SEPTIN12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.02125
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000140798,ABCC12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.5517% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.7778% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000140798,ABCC12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.323333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 93.3333% (minimum 99%, Missing); cerebellum: 96.5517% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); hippocampal formation: 77.7778% (minimum 99%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing)",0,80,unavailable,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000140798,ABCC12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.323333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.2,0.2,1.4,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000140932,CMTM2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,1.2,0.2,1.4,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000140932,CMTM2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0477859,0.0296831,0.00810157
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,1.2,0.2,1.4,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000140932,CMTM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0477859,0.0296831,0.00810157
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,10,partial,2.1,0.7,3.6,"basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000140955,ADAD2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.5194% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.7692% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.0679% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5893% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.5865% (minimum 95%, Baseline (adaptation disabled))",0,10,partial,2.1,0.7,3.6,"basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000140955,ADAD2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.00413534,0.0189937,-0.0223077
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.5194% (minimum 99%, Missing); basal ganglia: 96.7692% (minimum 99%, Missing); hippocampal formation: 98.5893% (minimum 99%, Missing)",0,10,partial,2.1,0.7,3.6,"basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000140955,ADAD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0421136,0.0268304,-0.0223077
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,9.5,6.3,7,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (manageable, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); kidney: 5.8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); colon: 4.8 nTPM (protected, limit 2); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); lymph node: 4 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140993,TIGD7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.1343% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.0556% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.0556% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.4528% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.4938% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.1233% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 50.7772% (minimum 99%, Baseline (adaptation disabled)); colon: 67.1233% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.7607% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.0556% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.8205% (minimum 99%, Baseline (adaptation disabled)); liver: 76.5625% (minimum 99%, Baseline (adaptation disabled)); lung: 77.1654% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.0145% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.5315% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.9690% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.8696% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.3672% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.4828% (minimum 97%, Baseline (adaptation disabled)); retina: 55.0562% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.0323% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.0145% (minimum 99%, Baseline (adaptation disabled)); skin: 79.6748% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.4000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 74.8092% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.0556% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.5862% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.0323% (minimum 97%, Baseline (adaptation disabled)); thymus: 73.1343% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.2162% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.5328% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,9.5,6.3,7,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (manageable, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); kidney: 5.8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); colon: 4.8 nTPM (protected, limit 2); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); lymph node: 4 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140993,TIGD7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.366667,-0.361304,-0.482228
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Uncertain); adrenal gland: 73.1343% (minimum 99%, Missing); amygdala: 68.0556% (minimum 99%, Missing); basal ganglia: 68.0556% (minimum 99%, Missing); bone marrow: 92.4528% (minimum 99%, Missing); cerebellum: 60.4938% (minimum 99%, Missing); cerebral cortex: 67.1233% (minimum 99%, Uncertain); choroid plexus: 50.7772% (minimum 99%, Missing); colon: 67.1233% (minimum 97%, Missing); duodenum: 83.7607% (minimum 99%, Missing); esophagus: 81.6667% (minimum 97%, Missing); heart muscle: 65.3333% (minimum 99%, Missing); hippocampal formation: 68.0556% (minimum 99%, Missing); hypothalamus: 65.3333% (minimum 99%, Missing); kidney: 62.8205% (minimum 99%, Missing); liver: 76.5625% (minimum 99%, Missing); lung: 77.1654% (minimum 99%, Missing); lymph node: 71.0145% (minimum 97%, Missing); midbrain: 68.5315% (minimum 99%, Missing); pancreas: 75.9690% (minimum 99%, Missing); parathyroid gland: 60.8696% (minimum 97%, Missing); pituitary gland: 55.3672% (minimum 99%, Missing); rectum: 84.4828% (minimum 97%, Missing); retina: 55.0562% (minimum 99%, Missing); salivary gland: 79.0323% (minimum 97%, Missing); skeletal muscle: 71.0145% (minimum 99%, Missing); skin: 79.6748% (minimum 95%, Missing); small intestine: 78.4000% (minimum 99%, Missing); smooth muscle: 74.8092% (minimum 99%, Missing); spinal cord: 68.0556% (minimum 99%, Missing); spleen: 67.5862% (minimum 95%, Uncertain); stomach: 79.0323% (minimum 97%, Missing); thymus: 73.1343% (minimum 95%, Missing); thyroid gland: 58.3333% (minimum 95%, Missing); tongue: 66.2162% (minimum 97%, Missing); urinary bladder: 71.5328% (minimum 97%, Missing)",0,3,partial,9.5,6.3,7,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (manageable, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); kidney: 5.8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); colon: 4.8 nTPM (protected, limit 2); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); lymph node: 4 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000140993,TIGD7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.366667,-0.361304,-0.482228
True,compatible,,True,True,False,,0,3,partial,1.7,0.6,2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000141096,DPEP3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.4135% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2796% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.7,0.6,2,"bone marrow: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000141096,DPEP3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.00807128,0.017041,-0.025865
True,compatible,,True,True,True,,0,3,partial,1.7,0.6,2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000141096,DPEP3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0478166,0.017041,0.0056427
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.5,0.4,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000141194,OR4D1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 28.5714% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 66.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 33.3333% (minimum 97%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 66.6667% (minimum 95%, Baseline (adaptation disabled)); spleen: 40.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 66.6667% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.4,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000141194,OR4D1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.55,-0.636667,-0.704286
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 28.5714% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 66.6667% (minimum 99%, Missing); lymph node: 33.3333% (minimum 97%, Missing); pancreas: 66.6667% (minimum 99%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 66.6667% (minimum 95%, Missing); spleen: 40.0000% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); urinary bladder: 66.6667% (minimum 97%, Missing)",0,80,unavailable,0.5,0.4,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000141194,OR4D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.55,-0.636667,-0.704286
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141200,KIF2B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0,0,routine_complete,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141200,KIF2B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0,0,routine_complete,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141200,KIF2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,22.9,20.7,17.1,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 2); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 2); thyroid gland: 15.4 nTPM (manageable, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 2); cerebellum: 13 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 2); spleen: 10.4 nTPM (manageable, limit 5); salivary gland: 10.3 nTPM (protected, limit 2); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 2); cerebral cortex: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 2); midbrain: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); esophagus: 8.3 nTPM (protected, limit 2); amygdala: 8.3 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141219,MTNAP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4411% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.0416% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.2650% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.5678% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.5481% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.7573% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.7101% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.8780% (minimum 99%, Baseline (adaptation disabled)); colon: 77.4648% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.2181% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.2650% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.9626% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.9741% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.0896% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.0870% (minimum 99%, Baseline (adaptation disabled)); liver: 80.3758% (minimum 99%, Baseline (adaptation disabled)); lung: 81.5678% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.4681% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.5678% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.0526% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.9024% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.8934% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.8755% (minimum 97%, Baseline (adaptation disabled)); retina: 63.3224% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.8934% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.7036% (minimum 99%, Baseline (adaptation disabled)); skin: 82.4411% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.7128% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.0870% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.4411% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.7321% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.7101% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.2446% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.4286% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.0338% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 81.3953% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,22.9,20.7,17.1,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 2); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 2); thyroid gland: 15.4 nTPM (manageable, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 2); cerebellum: 13 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 2); spleen: 10.4 nTPM (manageable, limit 5); salivary gland: 10.3 nTPM (protected, limit 2); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 2); cerebral cortex: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 2); midbrain: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); esophagus: 8.3 nTPM (protected, limit 2); amygdala: 8.3 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141219,MTNAP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.257554,-0.319662,-0.362964
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4411% (minimum 95%, Missing); adrenal gland: 80.0416% (minimum 99%, Missing); amygdala: 82.2650% (minimum 99%, Missing); basal ganglia: 81.5678% (minimum 99%, Missing); bone marrow: 92.5481% (minimum 99%, Missing); cerebellum: 74.7573% (minimum 99%, Missing); cerebral cortex: 79.7101% (minimum 99%, Missing); choroid plexus: 83.8780% (minimum 99%, Missing); colon: 77.4648% (minimum 97%, Missing); duodenum: 79.2181% (minimum 99%, Missing); esophagus: 82.2650% (minimum 97%, Missing); heart muscle: 71.9626% (minimum 99%, Missing); hippocampal formation: 82.9741% (minimum 99%, Missing); hypothalamus: 82.0896% (minimum 99%, Missing); kidney: 76.0870% (minimum 99%, Missing); liver: 80.3758% (minimum 99%, Missing); lung: 81.5678% (minimum 99%, Missing); lymph node: 74.4681% (minimum 97%, Missing); midbrain: 81.5678% (minimum 99%, Missing); pancreas: 81.0526% (minimum 99%, Missing); parathyroid gland: 70.9024% (minimum 97%, Missing); pituitary gland: 78.8934% (minimum 99%, Missing); rectum: 79.8755% (minimum 97%, Missing); retina: 63.3224% (minimum 99%, Missing); salivary gland: 78.8934% (minimum 97%, Missing); skeletal muscle: 62.7036% (minimum 99%, Missing); skin: 82.4411% (minimum 95%, Missing); small intestine: 80.7128% (minimum 99%, Missing); smooth muscle: 76.0870% (minimum 99%, Missing); spinal cord: 82.4411% (minimum 99%, Missing); spleen: 78.7321% (minimum 95%, Missing); stomach: 79.7101% (minimum 97%, Missing); thymus: 69.2446% (minimum 95%, Missing); thyroid gland: 71.4286% (minimum 95%, Missing); tongue: 65.0338% (minimum 97%, Missing); urinary bladder: 81.3953% (minimum 97%, Missing)",0,1,partial,22.9,20.7,17.1,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 2); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 2); thyroid gland: 15.4 nTPM (manageable, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 2); cerebellum: 13 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 2); spleen: 10.4 nTPM (manageable, limit 5); salivary gland: 10.3 nTPM (protected, limit 2); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 2); cerebral cortex: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 2); midbrain: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); esophagus: 8.3 nTPM (protected, limit 2); amygdala: 8.3 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141219,MTNAP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.257554,-0.319662,-0.362964
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,2.7,1,"parathyroid gland: 2.7 nTPM (protected, limit 2); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000141255,SPATA22,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,1.1,2.7,1,"parathyroid gland: 2.7 nTPM (protected, limit 2); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000141255,SPATA22,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0455437,0.0180584,0.00510022
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,1.1,2.7,1,"parathyroid gland: 2.7 nTPM (protected, limit 2); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000141255,SPATA22,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0455437,0.0180584,0.00510022
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,6,partial,20.3,0.2,0.3,"pancreas: 20.3 nTPM (vital, limit 6); choroid plexus: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000141316,SPACA3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.5437% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.7143% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,20.3,0.2,0.3,"pancreas: 20.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000141316,SPACA3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.047543,0.0283607,-0.132857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.5437% (minimum 99%, Missing); pancreas: 85.7143% (minimum 95%, Enhanced)",0,6,partial,20.3,0.2,0.3,"pancreas: 20.3 nTPM (vital, limit 6); choroid plexus: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000141316,SPACA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.0928571
True,compatible,,True,True,False,,0,4,partial,0.6,0.1,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; spleen; thymus,ENSG00000141371,CHCT1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0.6,0.1,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; spleen; thymus,ENSG00000141371,CHCT1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0462121,0.0292401,0.00545799
True,compatible,,True,True,True,,0,4,partial,0.6,0.1,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; spleen; thymus,ENSG00000141371,CHCT1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0492401,0.03,0.0084814
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,2.8,3,2.4,"lymph node: 3 nTPM (protected, limit 2); bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000141384,TAF4B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.2712% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.2308% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7447% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.8367% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.6438% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.5385% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.3571% (minimum 99%, Baseline (adaptation disabled)); colon: 73.7705% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.8367% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.8182% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.7500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.7447% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.7500% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8261% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.7447% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.3571% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.2353% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.7447% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.5862% (minimum 97%, Baseline (adaptation disabled)); retina: 93.7500% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.3571% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.5862% (minimum 99%, Baseline (adaptation disabled)); skin: 76.2712% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.9057% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.3571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.7447% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.2174% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.4286% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.5806% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 72.5806% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.2353% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,2.8,3,2.4,"lymph node: 3 nTPM (protected, limit 2); bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000141384,TAF4B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.297826,-0.37,-0.373562
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.2712% (minimum 95%, Uncertain); adrenal gland: 69.2308% (minimum 99%, Missing); amygdala: 95.7447% (minimum 99%, Missing); basal ganglia: 91.8367% (minimum 99%, Missing); bone marrow: 61.6438% (minimum 99%, Uncertain); cerebellum: 86.5385% (minimum 99%, Missing); cerebral cortex: 80.3571% (minimum 99%, Missing); colon: 73.7705% (minimum 97%, Missing); duodenum: 91.8367% (minimum 99%, Missing); esophagus: 81.8182% (minimum 97%, Missing); heart muscle: 93.7500% (minimum 99%, Missing); hippocampal formation: 95.7447% (minimum 99%, Missing); hypothalamus: 93.7500% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 97.8261% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 95.7447% (minimum 99%, Missing); pancreas: 80.3571% (minimum 99%, Missing); parathyroid gland: 88.2353% (minimum 97%, Missing); pituitary gland: 95.7447% (minimum 99%, Missing); rectum: 77.5862% (minimum 97%, Missing); retina: 93.7500% (minimum 99%, Missing); salivary gland: 80.3571% (minimum 97%, Missing); skeletal muscle: 77.5862% (minimum 99%, Missing); skin: 76.2712% (minimum 95%, Uncertain); small intestine: 84.9057% (minimum 99%, Missing); smooth muscle: 80.3571% (minimum 99%, Missing); spinal cord: 95.7447% (minimum 99%, Missing); spleen: 65.2174% (minimum 95%, Uncertain); stomach: 71.4286% (minimum 97%, Missing); thymus: 72.5806% (minimum 95%, Missing); thyroid gland: 72.5806% (minimum 95%, Missing); tongue: 88.2353% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,0,routine_complete,2.8,3,2.4,"lymph node: 3 nTPM (protected, limit 2); bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000141384,TAF4B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.297826,-0.37,-0.373562
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,11,partial,61.7,12.8,7.6,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 6); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 2); tongue: 12.6 nTPM (protected, limit 2); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); smooth muscle: 7.2 nTPM (vital, limit 6); colon: 6.9 nTPM (protected, limit 2); choroid plexus: 5 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); small intestine: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141404,GNAL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 68.9076% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.1348% (minimum 99%, Baseline (adaptation disabled)); amygdala: 48.9552% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 20.9987% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.3488% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.9317% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.6355% (minimum 99%, Baseline (adaptation disabled)); colon: 70.3863% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.6201% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.0498% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.8283% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 59.2058% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 57.1429% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.7882% (minimum 99%, Baseline (adaptation disabled)); liver: 89.1304% (minimum 99%, Baseline (adaptation disabled)); lung: 86.3158% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.7251% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.5659% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.1099% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.0952% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 50.9317% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.4121% (minimum 97%, Baseline (adaptation disabled)); retina: 80.3922% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.4689% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 43.8503% (minimum 99%, Baseline (adaptation disabled)); skin: 70.0855% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.1026% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.4915% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.8462% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.9741% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.5361% (minimum 97%, Baseline (adaptation disabled)); thymus: 79.6117% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 56.5517% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.1644% (minimum 97%, Baseline (adaptation disabled))",0,11,partial,61.7,12.8,7.6,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 2); tongue: 12.6 nTPM (protected, limit 2); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); adipose tissue: 7.4 nTPM (manageable, limit 5); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5); colon: 6.9 nTPM (protected, limit 2); choroid plexus: 5 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141404,GNAL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.266667,-0.408356,-0.780013
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.1348% (minimum 99%, Missing); amygdala: 48.9552% (minimum 99%, Missing); basal ganglia: 20.9987% (minimum 99%, Missing); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 50.9317% (minimum 95%, Enhanced); choroid plexus: 76.6355% (minimum 99%, Missing); colon: 70.3863% (minimum 97%, Missing); duodenum: 91.6201% (minimum 99%, Missing); esophagus: 68.0498% (minimum 80%, Enhanced); heart muscle: 82.8283% (minimum 95%, Enhanced); hippocampal formation: 59.2058% (minimum 99%, Missing); hypothalamus: 57.1429% (minimum 99%, Missing); kidney: 80.7882% (minimum 99%, Missing); liver: 89.1304% (minimum 95%, Enhanced); lung: 86.3158% (minimum 99%, Missing); lymph node: 77.7251% (minimum 97%, Missing); midbrain: 63.5659% (minimum 99%, Missing); pancreas: 90.1099% (minimum 95%, Enhanced); parathyroid gland: 78.0952% (minimum 80%, Enhanced); pituitary gland: 50.9317% (minimum 99%, Missing); rectum: 82.4121% (minimum 97%, Missing); retina: 80.3922% (minimum 99%, Missing); salivary gland: 78.4689% (minimum 80%, Enhanced); skeletal muscle: 43.8503% (minimum 95%, Enhanced); small intestine: 84.1026% (minimum 99%, Missing); smooth muscle: 69.4915% (minimum 95%, Enhanced); spinal cord: 78.8462% (minimum 99%, Missing); spleen: 84.9741% (minimum 95%, Missing); thymus: 79.6117% (minimum 95%, Missing); tongue: 56.5517% (minimum 97%, Missing); urinary bladder: 56.1644% (minimum 97%, Missing)",0,11,partial,61.7,12.8,7.6,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 6); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 2); tongue: 12.6 nTPM (protected, limit 2); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); smooth muscle: 7.2 nTPM (vital, limit 6); colon: 6.9 nTPM (protected, limit 2); choroid plexus: 5 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); small intestine: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141404,GNAL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.153883,-0.408356,-0.780013
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,12,partial,52.8,44.7,31.1,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 2); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 2); heart muscle: 28.1 nTPM (vital, limit 1); salivary gland: 27.4 nTPM (protected, limit 2); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 2); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 2); esophagus: 22.8 nTPM (protected, limit 2); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); spleen: 21.7 nTPM (manageable, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 2); smooth muscle: 20.6 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); rectum: 19.9 nTPM (protected, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); lymph node: 19 nTPM (protected, limit 2); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141425,RPRD1A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.3210% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.9336% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.9590% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.8435% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.9385% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.8017% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.9596% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.2807% (minimum 99%, Baseline (adaptation disabled)); colon: 79.7163% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.8671% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.1361% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.8451% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.9474% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.3314% (minimum 99%, Baseline (adaptation disabled)); liver: 84.1948% (minimum 99%, Baseline (adaptation disabled)); lung: 85.7361% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.5403% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.9961% (minimum 99%, Baseline (adaptation disabled)); pancreas: 83.1976% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 81.6860% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.5735% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.9584% (minimum 97%, Baseline (adaptation disabled)); retina: 73.6566% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.4006% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.0387% (minimum 99%, Baseline (adaptation disabled)); skin: 84.7662% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.9327% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.5113% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.4694% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.8180% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.4478% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.2807% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.3275% (minimum 95%, Baseline (adaptation disabled)); tongue: 71.5468% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.8052% (minimum 97%, Baseline (adaptation disabled))",0,12,partial,52.8,44.7,31.1,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 2); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 2); heart muscle: 28.1 nTPM (vital, limit 1); salivary gland: 27.4 nTPM (protected, limit 2); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 2); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 2); esophagus: 22.8 nTPM (protected, limit 2); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); spleen: 21.7 nTPM (manageable, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 2); smooth muscle: 20.6 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); rectum: 19.9 nTPM (protected, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); lymph node: 19 nTPM (protected, limit 2); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141425,RPRD1A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.166725,-0.254532,-0.309613
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.3210% (minimum 95%, Missing); adrenal gland: 76.9336% (minimum 99%, Missing); amygdala: 71.9590% (minimum 99%, Missing); basal ganglia: 75.8435% (minimum 99%, Missing); bone marrow: 90.9385% (minimum 99%, Missing); cerebellum: 73.8017% (minimum 99%, Missing); cerebral cortex: 70.9596% (minimum 99%, Missing); choroid plexus: 85.2807% (minimum 99%, Missing); colon: 79.7163% (minimum 97%, Missing); duodenum: 85.8671% (minimum 99%, Missing); esophagus: 83.1361% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 72.8451% (minimum 99%, Missing); hypothalamus: 73.9474% (minimum 99%, Missing); kidney: 81.3314% (minimum 99%, Missing); liver: 84.1948% (minimum 99%, Missing); lung: 85.7361% (minimum 99%, Missing); lymph node: 85.5403% (minimum 97%, Missing); midbrain: 73.9961% (minimum 99%, Missing); pancreas: 83.1976% (minimum 99%, Missing); parathyroid gland: 81.6860% (minimum 97%, Missing); pituitary gland: 80.5735% (minimum 99%, Missing); rectum: 84.9584% (minimum 97%, Missing); retina: 73.6566% (minimum 99%, Missing); salivary gland: 80.4006% (minimum 97%, Missing); skeletal muscle: 68.0387% (minimum 99%, Missing); skin: 84.7662% (minimum 95%, Missing); small intestine: 85.9327% (minimum 99%, Missing); smooth muscle: 84.5113% (minimum 99%, Missing); spinal cord: 72.4694% (minimum 99%, Missing); spleen: 83.8180% (minimum 95%, Missing); stomach: 84.4478% (minimum 97%, Missing); thymus: 85.2807% (minimum 95%, Missing); thyroid gland: 78.3275% (minimum 95%, Missing); tongue: 71.5468% (minimum 97%, Missing); urinary bladder: 80.8052% (minimum 97%, Missing)",0,12,partial,52.8,44.7,31.1,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 2); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 2); heart muscle: 28.1 nTPM (vital, limit 1); salivary gland: 27.4 nTPM (protected, limit 2); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 2); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 2); esophagus: 22.8 nTPM (protected, limit 2); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); spleen: 21.7 nTPM (manageable, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 2); smooth muscle: 20.6 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); rectum: 19.9 nTPM (protected, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); lymph node: 19 nTPM (protected, limit 2); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141425,RPRD1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.166725,-0.254532,-0.309613
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,0.8,0.9,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000141431,ASXL3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.4737% (minimum 95%, Baseline (adaptation disabled)); amygdala: 68.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.9524% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.4444% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.1250% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.2727% (minimum 99%, Baseline (adaptation disabled)); colon: 73.9130% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.4737% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 77.2727% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.8333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.3846% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.9130% (minimum 99%, Baseline (adaptation disabled)); liver: 80.9524% (minimum 99%, Baseline (adaptation disabled)); lung: 89.4737% (minimum 99%, Baseline (adaptation disabled)); midbrain: 73.9130% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.4737% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.8333% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.4444% (minimum 97%, Baseline (adaptation disabled)); retina: 77.2727% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.4737% (minimum 97%, Baseline (adaptation disabled)); skin: 94.4444% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.4737% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.9130% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.4444% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.0000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 65.3846% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 77.2727% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.5,0.8,0.9,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000141431,ASXL3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.296154,-0.29,-0.45875
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.4737% (minimum 95%, Missing); amygdala: 68.0000% (minimum 99%, Missing); basal ganglia: 80.9524% (minimum 99%, Missing); cerebellum: 94.4444% (minimum 99%, Missing); cerebral cortex: 53.1250% (minimum 99%, Missing); choroid plexus: 77.2727% (minimum 99%, Missing); colon: 73.9130% (minimum 97%, Missing); duodenum: 89.4737% (minimum 99%, Missing); heart muscle: 77.2727% (minimum 99%, Missing); hippocampal formation: 70.8333% (minimum 99%, Missing); hypothalamus: 65.3846% (minimum 99%, Missing); kidney: 73.9130% (minimum 99%, Missing); liver: 80.9524% (minimum 99%, Missing); lung: 89.4737% (minimum 99%, Missing); midbrain: 73.9130% (minimum 99%, Missing); pancreas: 85.0000% (minimum 99%, Missing); parathyroid gland: 89.4737% (minimum 97%, Missing); pituitary gland: 70.8333% (minimum 99%, Missing); rectum: 94.4444% (minimum 97%, Missing); retina: 77.2727% (minimum 99%, Missing); salivary gland: 89.4737% (minimum 97%, Missing); skin: 94.4444% (minimum 95%, Missing); small intestine: 85.0000% (minimum 99%, Missing); smooth muscle: 89.4737% (minimum 99%, Missing); spinal cord: 73.9130% (minimum 99%, Missing); spleen: 94.4444% (minimum 95%, Missing); stomach: 68.0000% (minimum 97%, Missing); thyroid gland: 65.3846% (minimum 95%, Missing); urinary bladder: 77.2727% (minimum 97%, Missing)",0,80,unavailable,1.5,0.8,0.9,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000141431,ASXL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.296154,-0.29,-0.45875
True,compatible,,True,True,False,,0,80,unavailable,0.6,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000141437,SLC25A52,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 94.3925% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.0583% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.2830% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000141437,SLC25A52,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0305825,0.03,-0.0460748
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 94.3925% (minimum 99%, Missing); pituitary gland: 98.0583% (minimum 99%, Missing); skeletal muscle: 95.2830% (minimum 99%, Missing)",0,80,unavailable,0.6,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000141437,SLC25A52,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0305825,0.03,-0.0460748
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.5,5.3,5.3,"spleen: 5.3 nTPM (manageable, limit 5); parathyroid gland: 5.3 nTPM (protected, limit 2); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000141497,ZMYND15,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.1781% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.4861% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.8567% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.1538% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.4912% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.5663% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.4861% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.2819% (minimum 99%, Baseline (adaptation disabled)); duodenum: 87.5796% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.8310% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.2143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.8567% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.1557% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.5374% (minimum 99%, Baseline (adaptation disabled)); liver: 90.1639% (minimum 99%, Baseline (adaptation disabled)); lung: 85.9375% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.5017% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.5374% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.8188% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.8415% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.4861% (minimum 99%, Baseline (adaptation disabled)); retina: 98.9209% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.1639% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.5663% (minimum 99%, Baseline (adaptation disabled)); small intestine: 90.4605% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.8648% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.5765% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.8415% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.8567% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.1781% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.5,5.3,5.3,"spleen: 5.3 nTPM (manageable, limit 5); parathyroid gland: 5.3 nTPM (protected, limit 2); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000141497,ZMYND15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.111585,-0.131585,-0.130625
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.1781% (minimum 95%, Missing); adrenal gland: 95.4861% (minimum 99%, Missing); amygdala: 93.8567% (minimum 99%, Missing); basal ganglia: 96.1538% (minimum 99%, Missing); bone marrow: 96.4912% (minimum 99%, Missing); cerebellum: 98.5663% (minimum 99%, Missing); cerebral cortex: 95.4861% (minimum 99%, Missing); choroid plexus: 92.2819% (minimum 99%, Missing); duodenum: 87.5796% (minimum 99%, Missing); esophagus: 96.8310% (minimum 97%, Missing); heart muscle: 98.2143% (minimum 99%, Missing); hippocampal formation: 93.8567% (minimum 99%, Missing); hypothalamus: 95.1557% (minimum 99%, Missing); kidney: 93.5374% (minimum 99%, Missing); liver: 90.1639% (minimum 99%, Missing); lung: 85.9375% (minimum 99%, Missing); lymph node: 94.5017% (minimum 97%, Missing); midbrain: 93.5374% (minimum 99%, Missing); pancreas: 95.8188% (minimum 99%, Missing); parathyroid gland: 83.8415% (minimum 97%, Missing); pituitary gland: 95.4861% (minimum 99%, Missing); retina: 98.9209% (minimum 99%, Missing); salivary gland: 90.1639% (minimum 97%, Missing); skeletal muscle: 98.5663% (minimum 99%, Missing); small intestine: 90.4605% (minimum 99%, Missing); smooth muscle: 97.8648% (minimum 99%, Missing); spinal cord: 89.5765% (minimum 99%, Missing); spleen: 83.8415% (minimum 95%, Missing); stomach: 93.8567% (minimum 97%, Missing); urinary bladder: 94.1781% (minimum 97%, Missing)",0,80,unavailable,4.5,5.3,5.3,"spleen: 5.3 nTPM (manageable, limit 5); parathyroid gland: 5.3 nTPM (protected, limit 2); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000141497,ZMYND15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.111585,-0.131585,-0.130625
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,1065.6,6.8,5.6,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 6); cerebral cortex: 14.6 nTPM (vital, limit 6); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1)",liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000141505,ASGR1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.1348% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.8339% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.3210% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.9869% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.4591% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.7974% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.7717% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.3821% (minimum 99%, Baseline (adaptation disabled)); colon: 95.5390% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.1147% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.1392% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.8955% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.9032% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.5933% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.1852% (minimum 99%, Baseline (adaptation disabled)); liver: 2.3550% (minimum 99%, Baseline (adaptation disabled)); lung: 87.1186% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.5390% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.8243% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.6165% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.0769% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.1754% (minimum 99%, Baseline (adaptation disabled)); retina: 84.8185% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.6165% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.8339% (minimum 99%, Baseline (adaptation disabled)); skin: 85.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.8339% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.1852% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.1348% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.5395% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.1852% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 82.1086% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.1392% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,1065.6,6.8,5.6,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); parathyroid gland: 6.8 nTPM (protected, limit 2); amygdala: 6.7 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000141505,ASGR1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.128914,-0.179231,-0.96645
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.8339% (minimum 95%, Enhanced); amygdala: 79.3210% (minimum 99%, Missing); basal ganglia: 83.9869% (minimum 99%, Missing); bone marrow: 91.4591% (minimum 95%, Enhanced); cerebellum: 54.7974% (minimum 95%, Enhanced); cerebral cortex: 63.7717% (minimum 95%, Enhanced); choroid plexus: 85.3821% (minimum 99%, Missing); duodenum: 92.1147% (minimum 95%, Enhanced); hippocampal formation: 82.9032% (minimum 99%, Missing); hypothalamus: 78.5933% (minimum 99%, Missing); liver: 2.3550% (minimum 99%, Missing); lung: 87.1186% (minimum 95%, Enhanced); midbrain: 86.8243% (minimum 99%, Missing); parathyroid gland: 79.0769% (minimum 80%, Enhanced); pituitary gland: 90.1754% (minimum 99%, Missing); retina: 84.8185% (minimum 99%, Missing); skeletal muscle: 94.8339% (minimum 95%, Enhanced); skin: 85.6667% (minimum 95%, Missing); small intestine: 94.8339% (minimum 95%, Enhanced); spinal cord: 91.1348% (minimum 99%, Missing); stomach: 95.1852% (minimum 97%, Missing)",0,5,partial,1065.6,6.8,5.6,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 6); cerebral cortex: 14.6 nTPM (vital, limit 6); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1)",liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000141505,ASGR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0933333,-0.0181481,-0.96645
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,75,42,13.1,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 2); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); adipose tissue: 13.1 nTPM (manageable, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000141576,RNF157,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.9541% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.5045% (minimum 99%, Baseline (adaptation disabled)); amygdala: 39.7653% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 42.1271% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.5583% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.1694% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 28.9100% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.6824% (minimum 99%, Baseline (adaptation disabled)); colon: 76.2500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.6332% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 83.1063% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 33.5903% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 47.2136% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.4875% (minimum 99%, Baseline (adaptation disabled)); liver: 92.7052% (minimum 99%, Baseline (adaptation disabled)); lung: 95.6113% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.9155% (minimum 97%, Baseline (adaptation disabled)); midbrain: 42.7171% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.2367% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.3857% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.9892% (minimum 97%, Baseline (adaptation disabled)); retina: 34.7777% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.1358% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 29.9902% (minimum 99%, Baseline (adaptation disabled)); small intestine: 75.1232% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.4272% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.1359% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.9705% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.1813% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.8675% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.2367% (minimum 95%, Baseline (adaptation disabled)); tongue: 42.0690% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 91.3174% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,75,42,13.1,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 2); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); adipose tissue: 13.1 nTPM (manageable, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000141576,RNF157,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.250459,-0.54931,-0.7009
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.9541% (minimum 95%, Missing); adrenal gland: 90.5045% (minimum 99%, Missing); amygdala: 39.7653% (minimum 99%, Missing); basal ganglia: 42.1271% (minimum 99%, Missing); bone marrow: 93.5583% (minimum 99%, Missing); cerebellum: 56.1694% (minimum 99%, Missing); cerebral cortex: 28.9100% (minimum 99%, Missing); choroid plexus: 75.6824% (minimum 99%, Missing); colon: 76.2500% (minimum 97%, Missing); duodenum: 76.6332% (minimum 99%, Missing); heart muscle: 83.1063% (minimum 99%, Missing); hippocampal formation: 33.5903% (minimum 99%, Missing); hypothalamus: 47.2136% (minimum 99%, Missing); kidney: 84.4875% (minimum 99%, Missing); liver: 92.7052% (minimum 99%, Missing); lung: 95.6113% (minimum 99%, Missing); lymph node: 85.9155% (minimum 97%, Missing); midbrain: 42.7171% (minimum 99%, Missing); pancreas: 90.2367% (minimum 99%, Missing); parathyroid gland: 68.3857% (minimum 97%, Missing); pituitary gland: 83.3333% (minimum 99%, Missing); rectum: 81.9892% (minimum 97%, Missing); retina: 34.7777% (minimum 99%, Missing); salivary gland: 94.1358% (minimum 97%, Missing); skeletal muscle: 29.9902% (minimum 99%, Missing); small intestine: 75.1232% (minimum 99%, Missing); smooth muscle: 94.4272% (minimum 99%, Missing); spinal cord: 53.1359% (minimum 99%, Missing); spleen: 89.9705% (minimum 95%, Missing); stomach: 89.1813% (minimum 97%, Missing); thymus: 91.8675% (minimum 95%, Missing); thyroid gland: 90.2367% (minimum 95%, Missing); tongue: 42.0690% (minimum 97%, Missing); urinary bladder: 91.3174% (minimum 97%, Missing)",0,80,unavailable,75,42,13.1,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 2); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); adipose tissue: 13.1 nTPM (manageable, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000141576,RNF157,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.250459,-0.54931,-0.7009
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,49.2,38.1,42.1,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); skin: 42.1 nTPM (manageable, limit 5); pituitary gland: 41.6 nTPM (vital, limit 1); spleen: 40 nTPM (manageable, limit 5); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 2); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 2); colon: 34.5 nTPM (protected, limit 2); heart muscle: 34.5 nTPM (vital, limit 1); cerebral cortex: 34.3 nTPM (vital, limit 1); thyroid gland: 34.3 nTPM (manageable, limit 5); urinary bladder: 34.2 nTPM (protected, limit 2); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 2); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 2); lymph node: 29.9 nTPM (protected, limit 2); salivary gland: 29.6 nTPM (protected, limit 2); thymus: 29.2 nTPM (manageable, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 2); adipose tissue: 27.6 nTPM (manageable, limit 10); basal ganglia: 26.1 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 2); rectum: 17.4 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141644,MBD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.6184% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.9766% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.1735% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.6338% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.1004% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.2215% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 71.3928% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.1498% (minimum 99%, Baseline (adaptation disabled)); colon: 71.2739% (minimum 97%, Baseline (adaptation disabled)); duodenum: 78.1022% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.1997% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.2739% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.2563% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.9668% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.0375% (minimum 99%, Baseline (adaptation disabled)); liver: 71.0963% (minimum 99%, Baseline (adaptation disabled)); lung: 74.6946% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.1126% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.2249% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.8724% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.0999% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.2956% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.1068% (minimum 97%, Baseline (adaptation disabled)); retina: 78.5321% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.3056% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.5015% (minimum 99%, Baseline (adaptation disabled)); skin: 67.0321% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.3584% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.8310% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.1529% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.4196% (minimum 97%, Baseline (adaptation disabled)); thymus: 74.5645% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.3928% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.3521% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.4524% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,49.2,38.1,42.1,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); skin: 42.1 nTPM (manageable, limit 5); pituitary gland: 41.6 nTPM (vital, limit 1); spleen: 40 nTPM (manageable, limit 5); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 2); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 1); colon: 34.5 nTPM (protected, limit 2); heart muscle: 34.5 nTPM (vital, limit 1); cerebral cortex: 34.3 nTPM (vital, limit 1); thyroid gland: 34.3 nTPM (manageable, limit 5); urinary bladder: 34.2 nTPM (protected, limit 2); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 2); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 2); lymph node: 29.9 nTPM (protected, limit 2); salivary gland: 29.6 nTPM (protected, limit 2); thymus: 29.2 nTPM (manageable, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 2); adipose tissue: 27.6 nTPM (manageable, limit 5); basal ganglia: 26.1 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141644,MBD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.279679,-0.278003,-0.354985
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.6184% (minimum 90%, Approved); adrenal gland: 68.9766% (minimum 99%, Missing); amygdala: 78.1735% (minimum 99%, Missing); basal ganglia: 76.6338% (minimum 99%, Missing); bone marrow: 66.1004% (minimum 99%, Missing); cerebellum: 70.2215% (minimum 99%, Missing); cerebral cortex: 71.3928% (minimum 99%, Missing); choroid plexus: 80.1498% (minimum 99%, Missing); colon: 71.2739% (minimum 97%, Missing); duodenum: 78.1022% (minimum 99%, Missing); esophagus: 69.1997% (minimum 97%, Missing); heart muscle: 71.2739% (minimum 99%, Missing); hippocampal formation: 77.2563% (minimum 99%, Missing); hypothalamus: 78.9668% (minimum 99%, Missing); kidney: 73.0375% (minimum 99%, Missing); liver: 71.0963% (minimum 98%, Approved); lung: 74.6946% (minimum 99%, Missing); lymph node: 74.1126% (minimum 97%, Missing); midbrain: 80.2249% (minimum 99%, Missing); pancreas: 71.8724% (minimum 99%, Missing); parathyroid gland: 73.0999% (minimum 97%, Missing); pituitary gland: 67.2956% (minimum 99%, Missing); rectum: 83.1068% (minimum 97%, Missing); retina: 78.5321% (minimum 99%, Missing); salivary gland: 74.3056% (minimum 97%, Missing); skeletal muscle: 63.5015% (minimum 99%, Missing); skin: 67.0321% (minimum 95%, Missing); small intestine: 72.3584% (minimum 99%, Missing); smooth muscle: 80.8310% (minimum 98%, Approved); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 68.1529% (minimum 95%, Missing); stomach: 72.4196% (minimum 97%, Missing); thymus: 74.5645% (minimum 95%, Missing); thyroid gland: 71.3928% (minimum 95%, Missing); tongue: 75.3521% (minimum 97%, Missing); urinary bladder: 71.4524% (minimum 97%, Missing)",0,5,partial,49.2,38.1,42.1,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); skin: 42.1 nTPM (manageable, limit 5); pituitary gland: 41.6 nTPM (vital, limit 1); spleen: 40 nTPM (manageable, limit 5); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 2); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 2); colon: 34.5 nTPM (protected, limit 2); heart muscle: 34.5 nTPM (vital, limit 1); cerebral cortex: 34.3 nTPM (vital, limit 1); thyroid gland: 34.3 nTPM (manageable, limit 5); urinary bladder: 34.2 nTPM (protected, limit 2); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 2); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 2); lymph node: 29.9 nTPM (protected, limit 2); salivary gland: 29.6 nTPM (protected, limit 2); thymus: 29.2 nTPM (manageable, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 2); adipose tissue: 27.6 nTPM (manageable, limit 10); basal ganglia: 26.1 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 2); rectum: 17.4 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000141644,MBD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.279679,-0.278003,-0.354985
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.3,0.6,0.6,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000141665,FBXO15,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.3418% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.1325% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.5714% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.2432% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.1463% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.4082% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.5714% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5714% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.2500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.1852% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.3418% (minimum 99%, Baseline (adaptation disabled)); liver: 94.5205% (minimum 99%, Baseline (adaptation disabled)); lung: 94.5205% (minimum 99%, Baseline (adaptation disabled)); midbrain: 88.4615% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.5205% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.1325% (minimum 99%, Baseline (adaptation disabled)); retina: 67.6471% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.8333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.5714% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.4615% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 92.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.3,0.6,0.6,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000141665,FBXO15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.03,-0.05,-0.313529
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.0000% (minimum 99%, Missing); amygdala: 87.3418% (minimum 99%, Missing); basal ganglia: 83.1325% (minimum 99%, Missing); bone marrow: 98.5714% (minimum 99%, Missing); cerebellum: 93.2432% (minimum 99%, Missing); cerebral cortex: 84.1463% (minimum 99%, Missing); choroid plexus: 70.4082% (minimum 99%, Missing); duodenum: 98.5714% (minimum 99%, Missing); heart muscle: 98.5714% (minimum 99%, Missing); hippocampal formation: 86.2500% (minimum 99%, Missing); hypothalamus: 85.1852% (minimum 99%, Missing); kidney: 87.3418% (minimum 99%, Missing); liver: 94.5205% (minimum 99%, Missing); lung: 94.5205% (minimum 99%, Missing); midbrain: 88.4615% (minimum 99%, Missing); pancreas: 94.5205% (minimum 99%, Missing); parathyroid gland: 92.0000% (minimum 97%, Missing); pituitary gland: 83.1325% (minimum 99%, Missing); retina: 67.6471% (minimum 99%, Missing); salivary gland: 95.8333% (minimum 97%, Missing); skeletal muscle: 98.5714% (minimum 99%, Missing); small intestine: 98.5714% (minimum 99%, Missing); spinal cord: 88.4615% (minimum 99%, Missing); thyroid gland: 92.0000% (minimum 95%, Missing)",0,80,unavailable,3.3,0.6,0.6,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000141665,FBXO15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.03,-0.05,-0.313529
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000141946,ZIM3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 75.0000% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000141946,ZIM3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.2,0.03,-0.39
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 75.0000% (minimum 99%, Missing); skeletal muscle: 60.0000% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); spleen: 75.0000% (minimum 95%, Missing)",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000141946,ZIM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.2,0.03,-0.39
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000141977,CIB3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 36.8421% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.5000% (minimum 97%, Baseline (adaptation disabled)); spleen: 87.5000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000141977,CIB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.075,-0.095,-0.621579
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 36.8421% (minimum 99%, Missing); lymph node: 87.5000% (minimum 97%, Missing); spleen: 87.5000% (minimum 95%, Missing)",0,80,unavailable,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000141977,CIB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.075,-0.095,-0.621579
True,compatible,,True,True,False,,0,3,partial,0.3,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000142025,DMRTC2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0.3,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000142025,DMRTC2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0474874,0.0249875,0.0025
True,compatible,,True,True,True,,0,3,partial,0.3,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000142025,DMRTC2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0474874,0.0249875,0.0025
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,9.5,3.6,2.9,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000142149,HUNK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.5385% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.8182% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.8182% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.9474% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.7447% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.9474% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.6438% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.7447% (minimum 99%, Baseline (adaptation disabled)); colon: 56.2500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.2712% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.8367% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.8367% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.2712% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.9474% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.5556% (minimum 99%, Baseline (adaptation disabled)); liver: 90.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.7500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.7500% (minimum 99%, Baseline (adaptation disabled)); pancreas: 32.1429% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 80.3571% (minimum 99%, Baseline (adaptation disabled)); rectum: 55.5556% (minimum 97%, Baseline (adaptation disabled)); retina: 60.8108% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.7500% (minimum 99%, Baseline (adaptation disabled)); skin: 60.8108% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.3803% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.1765% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.7500% (minimum 99%, Baseline (adaptation disabled)); stomach: 78.9474% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.5385% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.7447% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.2712% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,9.5,3.6,2.9,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000142149,HUNK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.341892,-0.414444,-0.668571
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 86.5385% (minimum 95%, Missing); adrenal gland: 81.8182% (minimum 99%, Missing); amygdala: 81.8182% (minimum 99%, Missing); basal ganglia: 78.9474% (minimum 99%, Missing); bone marrow: 95.7447% (minimum 99%, Missing); cerebellum: 78.9474% (minimum 99%, Missing); cerebral cortex: 61.6438% (minimum 99%, Missing); choroid plexus: 95.7447% (minimum 99%, Missing); colon: 56.2500% (minimum 97%, Missing); duodenum: 76.2712% (minimum 99%, Missing); esophagus: 91.8367% (minimum 97%, Missing); heart muscle: 91.8367% (minimum 99%, Missing); hippocampal formation: 76.2712% (minimum 99%, Missing); hypothalamus: 78.9474% (minimum 99%, Missing); kidney: 55.5556% (minimum 99%, Missing); liver: 90.0000% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 93.7500% (minimum 97%, Missing); midbrain: 93.7500% (minimum 99%, Missing); pancreas: 32.1429% (minimum 99%, Missing); pituitary gland: 80.3571% (minimum 99%, Missing); rectum: 55.5556% (minimum 97%, Missing); retina: 60.8108% (minimum 99%, Missing); salivary gland: 90.0000% (minimum 97%, Missing); skeletal muscle: 93.7500% (minimum 99%, Missing); skin: 60.8108% (minimum 95%, Missing); small intestine: 63.3803% (minimum 99%, Missing); smooth muscle: 66.1765% (minimum 99%, Missing); spinal cord: 93.7500% (minimum 99%, Missing); stomach: 78.9474% (minimum 97%, Missing); thymus: 86.5385% (minimum 95%, Missing); thyroid gland: 90.0000% (minimum 95%, Missing); tongue: 95.7447% (minimum 97%, Missing); urinary bladder: 76.2712% (minimum 97%, Missing)",0,2,partial,9.5,3.6,2.9,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000142149,HUNK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.341892,-0.414444,-0.668571
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0,56.2,0,"parathyroid gland: 56.2 nTPM (protected, limit 2)",,0,not_established,not_triggered,,,ENSG00000142511,GPR32,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 2.9361% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0,56.2,0,"parathyroid gland: 56.2 nTPM (protected, limit 2)",,0,not_established,not_triggered,,,ENSG00000142511,GPR32,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.940639,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 2.9361% (minimum 97%, Missing)",0,80,unavailable,0,56.2,0,"parathyroid gland: 56.2 nTPM (protected, limit 2)",,0,not_established,not_triggered,,,ENSG00000142511,GPR32,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.940639,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.1,1.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000142513,ACP4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 94.7368% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 87.8049% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.3077% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.7368% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.2973% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.1,1.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000142513,ACP4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.2,0.00297297,-0.111951
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 94.7368% (minimum 99%, Missing); bone marrow: 87.8049% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); pancreas: 94.7368% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 97.2973% (minimum 99%, Missing)",0,80,unavailable,0.5,0.1,1.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000142513,ACP4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.2,0.00297297,-0.111951
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9,2.5,2.2,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000142530,GARIN5A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6755% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.9646% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.2216% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.5431% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.4126% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.6278% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.5450% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.1555% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.4755% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.8673% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.6354% (minimum 99%, Baseline (adaptation disabled)); liver: 96.6278% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8064% (minimum 99%, Baseline (adaptation disabled)); midbrain: 89.3285% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.0052% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.0255% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4148% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.7532% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.3905% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8064% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.9045% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,9,2.5,2.2,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000142530,GARIN5A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0213168,-0.00246753,-0.0977844
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6755% (minimum 99%, Missing); amygdala: 90.9646% (minimum 99%, Missing); basal ganglia: 89.2216% (minimum 99%, Missing); cerebellum: 94.5431% (minimum 99%, Missing); cerebral cortex: 90.4126% (minimum 99%, Missing); choroid plexus: 96.6278% (minimum 99%, Missing); duodenum: 98.5450% (minimum 99%, Missing); heart muscle: 98.1555% (minimum 99%, Missing); hippocampal formation: 93.4755% (minimum 99%, Missing); hypothalamus: 89.8673% (minimum 99%, Missing); kidney: 95.6354% (minimum 99%, Missing); liver: 96.6278% (minimum 99%, Missing); lung: 98.8064% (minimum 99%, Missing); midbrain: 89.3285% (minimum 99%, Missing); pancreas: 97.0052% (minimum 99%, Missing); pituitary gland: 95.0255% (minimum 99%, Missing); retina: 98.4148% (minimum 99%, Missing); salivary gland: 96.7532% (minimum 97%, Missing); skeletal muscle: 95.3905% (minimum 99%, Missing); small intestine: 98.8064% (minimum 99%, Missing); spinal cord: 94.9045% (minimum 99%, Missing)",0,80,unavailable,9,2.5,2.2,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); salivary gland: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000142530,GARIN5A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0213168,-0.00246753,-0.0977844
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,ENSG00000142538,PTH2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"cerebellum: 16.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,ENSG00000142538,PTH2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.823333
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"cerebellum: 16.6667% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); midbrain: 66.6667% (minimum 99%, Missing)",0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,ENSG00000142538,PTH2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.823333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,10.2,2.2,1.2,"choroid plexus: 10.2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000142621,FHAD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.6842% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.3396% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.4634% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.5414% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 59.5238% (minimum 99%, Baseline (adaptation disabled)); duodenum: 94.9367% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.3614% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.2857% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.7742% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0392% (minimum 99%, Baseline (adaptation disabled)); lung: 81.0811% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.4026% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.5414% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.3396% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.1538% (minimum 99%, Baseline (adaptation disabled)); retina: 98.6842% (minimum 99%, Baseline (adaptation disabled)); small intestine: 93.7500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.0392% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4026% (minimum 99%, Baseline (adaptation disabled)); stomach: 87.2093% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.5926% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.9367% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,10.2,2.2,1.2,"choroid plexus: 10.2 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000142621,FHAD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0240741,-0.097907,-0.394762
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 94.3396% (minimum 99%, Missing); basal ganglia: 91.4634% (minimum 99%, Missing); choroid plexus: 59.5238% (minimum 99%, Missing); duodenum: 94.9367% (minimum 95%, Enhanced); hippocampal formation: 90.3614% (minimum 99%, Missing); hypothalamus: 89.2857% (minimum 99%, Missing); lung: 81.0811% (minimum 95%, Enhanced); midbrain: 97.4026% (minimum 99%, Missing); parathyroid gland: 94.3396% (minimum 97%, Missing); pituitary gland: 96.1538% (minimum 99%, Missing); retina: 98.6842% (minimum 99%, Missing); small intestine: 93.7500% (minimum 95%, Enhanced); spinal cord: 97.4026% (minimum 99%, Missing)",0,8,partial,10.2,2.2,1.2,"choroid plexus: 10.2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000142621,FHAD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0433775,-0.0266038,-0.394762
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,97.7,37.9,34.7,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 2); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (manageable, limit 5); esophagus: 31.6 nTPM (protected, limit 2); skin: 31.4 nTPM (manageable, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); spleen: 27.5 nTPM (manageable, limit 5); thyroid gland: 27.2 nTPM (manageable, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 2); hippocampal formation: 24.6 nTPM (vital, limit 1); salivary gland: 23.5 nTPM (protected, limit 2); colon: 22.9 nTPM (protected, limit 2); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 2); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 2); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 2); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000142684,ZNF593,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2644% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 50.2423% (minimum 99%, Baseline (adaptation disabled)); amygdala: 53.8062% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.0442% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.7422% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.8053% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 54.6573% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 43.1345% (minimum 99%, Baseline (adaptation disabled)); colon: 57.5926% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.1670% (minimum 99%, Baseline (adaptation disabled)); esophagus: 49.6013% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 45.8702% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.8348% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 52.4452% (minimum 99%, Baseline (adaptation disabled)); kidney: 44.3020% (minimum 99%, Baseline (adaptation disabled)); liver: 33.2976% (minimum 99%, Baseline (adaptation disabled)); lung: 59.5785% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.0391% (minimum 97%, Baseline (adaptation disabled)); midbrain: 52.0938% (minimum 99%, Baseline (adaptation disabled)); pancreas: 34.2511% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.3113% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.4367% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.8275% (minimum 97%, Baseline (adaptation disabled)); retina: 92.8358% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.9597% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 24.1460% (minimum 99%, Baseline (adaptation disabled)); skin: 49.7600% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.2713% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.2751% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 60.9804% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.0717% (minimum 95%, Baseline (adaptation disabled)); stomach: 45.0725% (minimum 97%, Baseline (adaptation disabled)); thymus: 87.3596% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.3448% (minimum 95%, Baseline (adaptation disabled)); tongue: 59.6929% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.7348% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,97.7,37.9,34.7,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 2); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (manageable, limit 5); esophagus: 31.6 nTPM (protected, limit 2); skin: 31.4 nTPM (manageable, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); spleen: 27.5 nTPM (manageable, limit 5); thyroid gland: 27.2 nTPM (manageable, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 2); hippocampal formation: 24.6 nTPM (vital, limit 1); salivary gland: 23.5 nTPM (protected, limit 2); colon: 22.9 nTPM (protected, limit 2); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 2); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 2); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 2); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000142684,ZNF593,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.477356,-0.519275,-0.74854
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2644% (minimum 95%, Missing); adrenal gland: 50.2423% (minimum 99%, Missing); amygdala: 53.8062% (minimum 99%, Missing); basal ganglia: 55.0442% (minimum 99%, Missing); bone marrow: 60.7422% (minimum 99%, Missing); cerebellum: 68.8053% (minimum 99%, Missing); cerebral cortex: 54.6573% (minimum 99%, Missing); choroid plexus: 43.1345% (minimum 99%, Missing); colon: 57.5926% (minimum 97%, Missing); duodenum: 71.1670% (minimum 99%, Missing); esophagus: 49.6013% (minimum 97%, Missing); heart muscle: 45.8702% (minimum 99%, Missing); hippocampal formation: 55.8348% (minimum 99%, Missing); hypothalamus: 52.4452% (minimum 99%, Missing); kidney: 44.3020% (minimum 99%, Missing); liver: 33.2976% (minimum 99%, Missing); lung: 59.5785% (minimum 99%, Missing); lymph node: 76.0391% (minimum 97%, Missing); midbrain: 52.0938% (minimum 99%, Missing); pancreas: 34.2511% (minimum 99%, Missing); parathyroid gland: 66.3113% (minimum 97%, Missing); pituitary gland: 55.4367% (minimum 99%, Missing); rectum: 83.8275% (minimum 97%, Missing); retina: 92.8358% (minimum 99%, Missing); salivary gland: 56.9597% (minimum 97%, Missing); skeletal muscle: 24.1460% (minimum 99%, Missing); skin: 49.7600% (minimum 95%, Missing); small intestine: 60.2713% (minimum 99%, Missing); smooth muscle: 82.2751% (minimum 99%, Missing); spinal cord: 60.9804% (minimum 99%, Missing); spleen: 53.0717% (minimum 95%, Missing); stomach: 45.0725% (minimum 97%, Missing); thymus: 87.3596% (minimum 95%, Missing); thyroid gland: 53.3448% (minimum 95%, Missing); tongue: 59.6929% (minimum 97%, Missing); urinary bladder: 55.7348% (minimum 97%, Missing)",0,5,partial,97.7,37.9,34.7,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 2); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (manageable, limit 5); esophagus: 31.6 nTPM (protected, limit 2); skin: 31.4 nTPM (manageable, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); spleen: 27.5 nTPM (manageable, limit 5); thyroid gland: 27.2 nTPM (manageable, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 2); hippocampal formation: 24.6 nTPM (vital, limit 1); salivary gland: 23.5 nTPM (protected, limit 2); colon: 22.9 nTPM (protected, limit 2); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 2); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 2); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 2); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000142684,ZNF593,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.477356,-0.519275,-0.74854
True,compatible,,True,True,False,,0,80,unavailable,0.7,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000142698,C1orf94,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 96.9388% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.9381% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.4467% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.4359% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.9388% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.4359% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.9388% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000142698,C1orf94,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.025533
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 96.9388% (minimum 99%, Missing); basal ganglia: 97.9381% (minimum 99%, Missing); cerebral cortex: 96.4467% (minimum 99%, Missing); hippocampal formation: 97.4359% (minimum 99%, Missing); hypothalamus: 96.9388% (minimum 99%, Missing); midbrain: 97.4359% (minimum 99%, Missing); spinal cord: 96.9388% (minimum 99%, Missing)",0,80,unavailable,0.7,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000142698,C1orf94,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.025533
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,22.3,7.3,14,"bone marrow: 22.3 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 2); rectum: 4.1 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000142731,PLK4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.6522% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.9163% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.0699% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.6614% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.0699% (minimum 99%, Baseline (adaptation disabled)); colon: 86.6142% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.0688% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.3016% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.7778% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.7778% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.3451% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.3451% (minimum 99%, Baseline (adaptation disabled)); liver: 96.4912% (minimum 99%, Baseline (adaptation disabled)); lung: 96.0699% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.0853% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.3451% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2143% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.2912% (minimum 97%, Baseline (adaptation disabled)); retina: 91.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0699% (minimum 97%, Baseline (adaptation disabled)); skin: 90.5350% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.7097% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.4370% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.9163% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.2203% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.0502% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.1111% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.4206% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,22.3,7.3,14,"bone marrow: 22.3 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 2); rectum: 4.1 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000142731,PLK4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.338889,-0.219147,-0.493386
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.6522% (minimum 98%, Approved); amygdala: 96.9163% (minimum 99%, Missing); basal ganglia: 96.0699% (minimum 99%, Missing); bone marrow: 49.6614% (minimum 99%, Missing); cerebral cortex: 96.0699% (minimum 99%, Missing); colon: 86.6142% (minimum 97%, Missing); duodenum: 89.0688% (minimum 99%, Missing); esophagus: 87.3016% (minimum 97%, Missing); heart muscle: 97.7778% (minimum 98%, Approved); hippocampal formation: 97.7778% (minimum 99%, Missing); hypothalamus: 97.3451% (minimum 99%, Missing); kidney: 97.3451% (minimum 99%, Missing); liver: 96.4912% (minimum 99%, Missing); lung: 96.0699% (minimum 99%, Missing); lymph node: 75.0853% (minimum 97%, Missing); midbrain: 97.3451% (minimum 99%, Missing); pancreas: 98.2143% (minimum 99%, Missing); rectum: 84.2912% (minimum 97%, Missing); retina: 91.6667% (minimum 99%, Missing); salivary gland: 96.0699% (minimum 97%, Missing); skin: 90.5350% (minimum 95%, Missing); small intestine: 88.7097% (minimum 99%, Missing); smooth muscle: 92.4370% (minimum 98%, Approved); spinal cord: 96.9163% (minimum 99%, Missing); spleen: 93.2203% (minimum 95%, Missing); stomach: 92.0502% (minimum 97%, Missing); thymus: 61.1111% (minimum 95%, Missing); urinary bladder: 94.4206% (minimum 95%, Approved)",0,1,partial,22.3,7.3,14,"bone marrow: 22.3 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 2); rectum: 4.1 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000142731,PLK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.338889,-0.219147,-0.493386
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,21.6,3.4,2.5,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000142920,AZIN2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 89.3983% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.5894% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.2836% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.5397% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.5581% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.2000% (minimum 99%, Baseline (adaptation disabled)); colon: 90.1734% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.7342% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 89.9135% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.5849% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.5894% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.3077% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8056% (minimum 99%, Baseline (adaptation disabled)); lung: 96.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 72.8972% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.1220% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.6977% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.1734% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.5944% (minimum 97%, Baseline (adaptation disabled)); retina: 91.4956% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.6937% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.8944% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.2963% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.0909% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.8944% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.5816% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.2598% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.7055% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,21.6,3.4,2.5,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000142920,AZIN2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.024184,-0.0682659,-0.399091
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 89.3983% (minimum 99%, Missing); amygdala: 78.5894% (minimum 99%, Missing); basal ganglia: 76.2836% (minimum 99%, Missing); cerebellum: 82.5397% (minimum 99%, Missing); cerebral cortex: 72.5581% (minimum 99%, Missing); choroid plexus: 83.2000% (minimum 99%, Missing); colon: 90.1734% (minimum 97%, Missing); duodenum: 98.7342% (minimum 99%, Missing); heart muscle: 89.9135% (minimum 99%, Missing); hippocampal formation: 73.5849% (minimum 99%, Missing); hypothalamus: 78.5894% (minimum 99%, Missing); kidney: 92.3077% (minimum 99%, Missing); liver: 97.8056% (minimum 99%, Missing); lung: 96.0000% (minimum 99%, Missing); midbrain: 72.8972% (minimum 99%, Missing); pancreas: 95.1220% (minimum 99%, Missing); parathyroid gland: 90.6977% (minimum 97%, Missing); pituitary gland: 90.1734% (minimum 99%, Missing); rectum: 96.5944% (minimum 97%, Missing); retina: 91.4956% (minimum 99%, Missing); salivary gland: 93.6937% (minimum 97%, Missing); skeletal muscle: 96.8944% (minimum 99%, Missing); small intestine: 96.2963% (minimum 99%, Missing); smooth muscle: 96.0000% (minimum 99%, Missing); spinal cord: 59.0909% (minimum 99%, Missing); stomach: 96.8944% (minimum 97%, Missing); thyroid gland: 92.5816% (minimum 95%, Missing); tongue: 94.2598% (minimum 97%, Missing); urinary bladder: 95.7055% (minimum 97%, Missing)",0,80,unavailable,21.6,3.4,2.5,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000142920,AZIN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.024184,-0.0682659,-0.399091
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,12,partial,32.6,16.1,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6 nTPM (protected, limit 2); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells,ENSG00000142945,KIF2C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5042% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.6720% (minimum 99%, Baseline (adaptation disabled)); colon: 92.5280% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3417% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.2776% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.4106% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.9348% (minimum 99%, Baseline (adaptation disabled)); lung: 98.4106% (minimum 99%, Baseline (adaptation disabled)); lymph node: 82.1903% (minimum 97%, Baseline (adaptation disabled)); rectum: 90.9425% (minimum 97%, Baseline (adaptation disabled)); retina: 98.9348% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.9348% (minimum 99%, Baseline (adaptation disabled)); skin: 92.7591% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.6948% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.9948% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.6242% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.1183% (minimum 95%, Baseline (adaptation disabled))",0,12,partial,32.6,16.1,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); esophagus: 7.1 nTPM (protected, limit 2); colon: 6 nTPM (protected, limit 2); skin: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells,ENSG00000142945,KIF2C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.278817,-0.148097,-0.294958
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5042% (minimum 99%, Missing); choroid plexus: 98.6720% (minimum 99%, Missing); colon: 92.5280% (minimum 97%, Missing); duodenum: 93.3417% (minimum 99%, Missing); lymph node: 82.1903% (minimum 97%, Missing); rectum: 90.9425% (minimum 97%, Missing); retina: 98.9348% (minimum 99%, Missing); small intestine: 93.6948% (minimum 99%, Missing); thymus: 67.1183% (minimum 95%, Missing)",0,12,partial,32.6,16.1,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6 nTPM (protected, limit 2); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells,ENSG00000142945,KIF2C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.278817,-0.148097,-0.294958
True,compatible,,True,True,False,,0,2,partial,0,0,0.1,,,55,not_established,not_triggered,,,ENSG00000143006,DMRTB1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0.1,,,55,not_established,not_triggered,,,ENSG00000143006,DMRTB1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0483607,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0.1,,,55,not_established,not_triggered,,,ENSG00000143006,DMRTB1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,43.9,0,0,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000143032,BARHL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.6522% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 4.7722% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.6522% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); midbrain: 88.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 44.8980% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.8621% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,43.9,0,0,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000143032,BARHL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.942278
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.6522% (minimum 99%, Missing); cerebellum: 4.7722% (minimum 99%, Missing); cerebral cortex: 91.6667% (minimum 99%, Missing); choroid plexus: 95.6522% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); midbrain: 88.0000% (minimum 99%, Missing); retina: 44.8980% (minimum 99%, Missing); spinal cord: 75.8621% (minimum 99%, Missing)",0,80,unavailable,43.9,0,0,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000143032,BARHL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.942278
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,ENSG00000143105,KCNA10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); thymus: 66.6667% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,ENSG00000143105,KCNA10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,0.03,-0.19
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"lung: 80.0000% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); thymus: 66.6667% (minimum 95%, Missing)",0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,ENSG00000143105,KCNA10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,0.03,-0.19
True,compatible,,True,True,False,,0,4,partial,0.4,0,0,,,51,not_established,not_triggered,,,ENSG00000143107,FNDC7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 84.6154% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.6154% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.5714% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.6154% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 84.6154% (minimum 99%, Baseline (adaptation disabled)); retina: 73.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.6667% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,0.4,0,0,,,51,not_established,not_triggered,,,ENSG00000143107,FNDC7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.256667
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 84.6154% (minimum 99%, Missing); basal ganglia: 84.6154% (minimum 99%, Missing); bone marrow: 91.6667% (minimum 95%, Enhanced); cerebellum: 91.6667% (minimum 95%, Enhanced); cerebral cortex: 91.6667% (minimum 95%, Enhanced); hippocampal formation: 78.5714% (minimum 99%, Missing); hypothalamus: 84.6154% (minimum 99%, Missing); pituitary gland: 84.6154% (minimum 99%, Missing); retina: 73.3333% (minimum 99%, Missing); spinal cord: 91.6667% (minimum 99%, Missing)",0,4,partial,0.4,0,0,,,51,not_established,not_triggered,,,ENSG00000143107,FNDC7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.256667
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,5,partial,5.4,1.2,0.1,"heart muscle: 5.4 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; thymus; tonsil,ENSG00000143194,MAEL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.7229% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9757% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.8481% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.6250% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.7229% (minimum 99%, Baseline (adaptation disabled)); retina: 97.3552% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,5.4,1.2,0.1,"heart muscle: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; thymus; tonsil,ENSG00000143194,MAEL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0493536,0.0222978,-0.02375
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.7229% (minimum 99%, Missing); cerebral cortex: 97.8481% (minimum 98%, Approved); heart muscle: 96.6250% (minimum 98%, Approved); hippocampal formation: 98.7229% (minimum 99%, Missing); retina: 97.3552% (minimum 99%, Missing)",0,5,partial,5.4,1.2,0.1,"heart muscle: 5.4 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; thymus; tonsil,ENSG00000143194,MAEL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0493536,0.0222978,-0.0164484
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,5.9,0.2,0.1,"liver: 5.9 nTPM (vital, limit 2)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / squamous epithelial cells,ENSG00000143199,ADCY10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8439% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.8439% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2759% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.9355% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.7143% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.2759% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.8439% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2759% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.2759% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.7143% (minimum 99%, Baseline (adaptation disabled)); liver: 74.3478% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8439% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.8439% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7143% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8439% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8439% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,5.9,0.2,0.1,"liver: 5.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / squamous epithelial cells,ENSG00000143199,ADCY10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.044186,0.0184393,-0.246522
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8439% (minimum 99%, Missing); amygdala: 98.8439% (minimum 99%, Missing); basal ganglia: 98.2759% (minimum 99%, Missing); cerebellum: 91.9355% (minimum 98%, Approved); cerebral cortex: 97.7143% (minimum 99%, Missing); duodenum: 98.2759% (minimum 99%, Missing); hippocampal formation: 98.2759% (minimum 99%, Missing); hypothalamus: 98.2759% (minimum 99%, Missing); kidney: 97.7143% (minimum 99%, Missing); liver: 74.3478% (minimum 98%, Approved); lung: 98.8439% (minimum 99%, Missing); midbrain: 98.8439% (minimum 99%, Missing); pancreas: 97.7143% (minimum 99%, Missing); small intestine: 98.8439% (minimum 99%, Missing); spinal cord: 98.8439% (minimum 99%, Missing)",0,3,partial,5.9,0.2,0.1,"liver: 5.9 nTPM (vital, limit 2)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / squamous epithelial cells,ENSG00000143199,ADCY10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.044186,0.0184393,-0.236522
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,28,17.8,25.3,"bone marrow: 28 nTPM (vital, limit 1); thymus: 25.3 nTPM (manageable, limit 5); lymph node: 17.8 nTPM (protected, limit 2); esophagus: 5.6 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143228,NUF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8593% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.4848% (minimum 99%, Baseline (adaptation disabled)); colon: 92.6916% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.5267% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.2778% (minimum 97%, Baseline (adaptation disabled)); liver: 98.6717% (minimum 99%, Baseline (adaptation disabled)); lung: 98.2987% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.4986% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.8593% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.0683% (minimum 97%, Baseline (adaptation disabled)); retina: 97.3783% (minimum 99%, Baseline (adaptation disabled)); skin: 92.8571% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.5267% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.9410% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2987% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.6937% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.4128% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.2704% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.6543% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,28,17.8,25.3,"bone marrow: 28 nTPM (vital, limit 1); thymus: 25.3 nTPM (manageable, limit 5); lymph node: 17.8 nTPM (protected, limit 2); esophagus: 5.6 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143228,NUF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.277296,-0.225014,-0.34
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8593% (minimum 99%, Missing); bone marrow: 65.0000% (minimum 99%, Missing); cerebral cortex: 98.4848% (minimum 99%, Missing); colon: 92.6916% (minimum 97%, Missing); duodenum: 92.5267% (minimum 99%, Missing); esophagus: 90.2778% (minimum 97%, Missing); liver: 98.6717% (minimum 99%, Missing); lung: 98.2987% (minimum 99%, Missing); lymph node: 74.4986% (minimum 97%, Missing); midbrain: 98.8593% (minimum 99%, Missing); rectum: 91.0683% (minimum 97%, Missing); retina: 97.3783% (minimum 99%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 92.5267% (minimum 99%, Missing); smooth muscle: 95.9410% (minimum 99%, Missing); spinal cord: 98.2987% (minimum 99%, Missing); spleen: 93.6937% (minimum 95%, Missing); stomach: 95.4128% (minimum 97%, Missing); thymus: 67.2704% (minimum 95%, Missing); urinary bladder: 96.6543% (minimum 97%, Missing)",0,80,unavailable,28,17.8,25.3,"bone marrow: 28 nTPM (vital, limit 1); thymus: 25.3 nTPM (manageable, limit 5); lymph node: 17.8 nTPM (protected, limit 2); esophagus: 5.6 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143228,NUF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.277296,-0.225014,-0.34
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,28.8,1.6,15.6,"pituitary gland: 28.8 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000143340,FAM163A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9558% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.3488% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.4412% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.6190% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.6735% (minimum 99%, Baseline (adaptation disabled)); colon: 88.4892% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.7910% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.0938% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.4000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.6154% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.3488% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.8931% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.8504% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 29.9270% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.0938% (minimum 97%, Baseline (adaptation disabled)); retina: 94.6154% (minimum 99%, Baseline (adaptation disabled)); small intestine: 92.4812% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.8504% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.1818% (minimum 97%, Baseline (adaptation disabled)); thymus: 44.0860% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.8931% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,28.8,1.6,15.6,"pituitary gland: 28.8 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000143340,FAM163A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.50914,-0.0851079,-0.69073
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9558% (minimum 99%, Missing); amygdala: 95.3488% (minimum 99%, Missing); basal ganglia: 90.4412% (minimum 99%, Missing); cerebellum: 97.6190% (minimum 99%, Missing); cerebral cortex: 83.6735% (minimum 99%, Missing); colon: 88.4892% (minimum 97%, Missing); duodenum: 91.7910% (minimum 99%, Missing); heart muscle: 96.0938% (minimum 99%, Missing); hippocampal formation: 98.4000% (minimum 99%, Missing); hypothalamus: 94.6154% (minimum 99%, Missing); lymph node: 95.3488% (minimum 97%, Missing); midbrain: 93.8931% (minimum 99%, Missing); pancreas: 96.8504% (minimum 99%, Missing); pituitary gland: 29.9270% (minimum 99%, Missing); rectum: 96.0938% (minimum 97%, Missing); retina: 94.6154% (minimum 99%, Missing); small intestine: 92.4812% (minimum 99%, Missing); smooth muscle: 96.8504% (minimum 99%, Missing); stomach: 93.1818% (minimum 97%, Missing); thymus: 44.0860% (minimum 95%, Missing); thyroid gland: 93.8931% (minimum 95%, Missing)",0,80,unavailable,28.8,1.6,15.6,"pituitary gland: 28.8 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000143340,FAM163A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.50914,-0.0851079,-0.69073
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.6,0,0.1,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000143355,LHX9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.3158% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.9189% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.8254% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.8610% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9189% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.8462% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8610% (minimum 99%, Baseline (adaptation disabled)); lung: 92.8934% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.9189% (minimum 99%, Baseline (adaptation disabled)); retina: 83.5616% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.6,0,0.1,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000143355,LHX9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0445652,0.03,-0.154384
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.3158% (minimum 99%, Missing); basal ganglia: 98.9189% (minimum 99%, Missing); choroid plexus: 96.8254% (minimum 99%, Missing); heart muscle: 97.8610% (minimum 99%, Missing); hippocampal formation: 98.9189% (minimum 99%, Missing); hypothalamus: 93.8462% (minimum 99%, Missing); liver: 97.8610% (minimum 99%, Missing); lung: 92.8934% (minimum 99%, Missing); midbrain: 98.9189% (minimum 99%, Missing); retina: 83.5616% (minimum 99%, Missing)",0,80,unavailable,3.6,0,0.1,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000143355,LHX9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0445652,0.03,-0.154384
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,9.9,5.3,7.9,"adrenal gland: 9.9 nTPM (vital, limit 6); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 6); heart muscle: 7.7 nTPM (vital, limit 6); pancreas: 7.3 nTPM (vital, limit 6); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); retina: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143443,C1orf56,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.4162% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.2562% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.8763% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.6298% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.1772% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.1240% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.2331% (minimum 99%, Baseline (adaptation disabled)); colon: 94.0582% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.3822% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.4673% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.6212% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.5071% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.7529% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.0792% (minimum 99%, Baseline (adaptation disabled)); liver: 90.1818% (minimum 99%, Baseline (adaptation disabled)); lung: 96.3731% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.3846% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.0649% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.7529% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.4661% (minimum 99%, Baseline (adaptation disabled)); retina: 97.5098% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.3501% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.1933% (minimum 99%, Baseline (adaptation disabled)); skin: 94.7771% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.6298% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5430% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.3846% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.6565% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.3501% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 90.4010% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.7028% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,9.9,5.3,7.9,"adrenal gland: 9.9 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); thyroid gland: 7.9 nTPM (manageable, limit 5); heart muscle: 7.7 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); salivary gland: 5.3 nTPM (protected, limit 2); esophagus: 5.2 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 2); colon: 4.7 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); amygdala: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143443,C1orf56,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0459903,-0.0364994,-0.107438
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 88.2562% (minimum 95%, Enhanced); amygdala: 95.8763% (minimum 99%, Missing); basal ganglia: 95.6298% (minimum 99%, Missing); cerebellum: 94.1772% (minimum 95%, Enhanced); choroid plexus: 93.2331% (minimum 99%, Missing); heart muscle: 90.6212% (minimum 95%, Enhanced); hippocampal formation: 95.5071% (minimum 99%, Missing); hypothalamus: 95.7529% (minimum 99%, Missing); kidney: 92.0792% (minimum 99%, Missing); liver: 90.1818% (minimum 95%, Enhanced); midbrain: 95.3846% (minimum 99%, Missing); pancreas: 91.0649% (minimum 95%, Enhanced); pituitary gland: 88.4661% (minimum 99%, Missing); retina: 97.5098% (minimum 99%, Missing); skeletal muscle: 92.1933% (minimum 95%, Enhanced); spinal cord: 95.3846% (minimum 99%, Missing)",0,4,partial,9.9,5.3,7.9,"adrenal gland: 9.9 nTPM (vital, limit 6); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 6); heart muscle: 7.7 nTPM (vital, limit 6); pancreas: 7.3 nTPM (vital, limit 6); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); retina: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143443,C1orf56,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0446524,0.00127937,-0.105339
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.8,7.5,2.1,"salivary gland: 7.5 nTPM (protected, limit 2); parathyroid gland: 4.1 nTPM (protected, limit 2); skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143450,OAZ3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 98.9556% (minimum 99%, Baseline (adaptation disabled)); retina: 98.6465% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.1929% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.5439% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.8,7.5,2.1,"salivary gland: 7.5 nTPM (protected, limit 2); parathyroid gland: 4.1 nTPM (protected, limit 2); skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143450,OAZ3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,0.0390397,-0.00807107,-0.00456058
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 98.9556% (minimum 99%, Missing); retina: 98.6465% (minimum 99%, Missing); salivary gland: 96.1929% (minimum 97%, Missing); skeletal muscle: 98.5439% (minimum 99%, Missing)",0,80,unavailable,2.8,7.5,2.1,"salivary gland: 7.5 nTPM (protected, limit 2); parathyroid gland: 4.1 nTPM (protected, limit 2); skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143450,OAZ3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,0.0390397,-0.00807107,-0.00456058
True,compatible,,True,True,False,,0,3,partial,0.5,3.5,6.6,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000143452,HORMAD1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 94.5409% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,0.5,3.5,6.6,"skin: 6.6 nTPM (manageable, limit 5); esophagus: 3.5 nTPM (protected, limit 2)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000143452,HORMAD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,-0.00459057,0.000288625,0.0056446
True,compatible,,True,True,True,,0,3,partial,0.5,3.5,6.6,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000143452,HORMAD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.00912587
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.8,0.1,6,"thyroid gland: 6 nTPM (manageable, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000143469,SYT14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.1111% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.1176% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.1176% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.7451% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.1176% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.1176% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.1176% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.4286% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 84.2105% (minimum 99%, Baseline (adaptation disabled)); retina: 45.7143% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.1176% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 34.7826% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.9697% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.8,0.1,6,"thyroid gland: 6 nTPM (manageable, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000143469,SYT14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.602174,-0.00030303,-0.532857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.1111% (minimum 99%, Missing); amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 94.1176% (minimum 99%, Missing); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 62.7451% (minimum 99%, Missing); hippocampal formation: 94.1176% (minimum 99%, Missing); hypothalamus: 94.1176% (minimum 99%, Missing); midbrain: 94.1176% (minimum 99%, Missing); pancreas: 91.4286% (minimum 99%, Missing); pituitary gland: 84.2105% (minimum 99%, Missing); retina: 45.7143% (minimum 99%, Missing); spinal cord: 94.1176% (minimum 99%, Missing); thyroid gland: 34.7826% (minimum 95%, Missing); tongue: 96.9697% (minimum 97%, Missing)",0,80,unavailable,3.8,0.1,6,"thyroid gland: 6 nTPM (manageable, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000143469,SYT14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.602174,-0.00030303,-0.532857
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,14.4,5.4,13.8,"bone marrow: 14.4 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); lymph node: 5.4 nTPM (protected, limit 2); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); skin 2 / epidermal cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143476,DTL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.5185% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.0144% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.0803% (minimum 99%, Baseline (adaptation disabled)); colon: 80.6061% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.8065% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.5000% (minimum 97%, Baseline (adaptation disabled)); liver: 91.7241% (minimum 99%, Baseline (adaptation disabled)); lung: 90.4762% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.1230% (minimum 97%, Baseline (adaptation disabled)); parathyroid gland: 96.3768% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.5185% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.3017% (minimum 97%, Baseline (adaptation disabled)); skin: 86.3636% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.0988% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.0795% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.1772% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.0959% (minimum 97%, Baseline (adaptation disabled)); thymus: 49.0775% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.3611% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,14.4,5.4,13.8,"bone marrow: 14.4 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); lymph node: 5.4 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); skin 2 / epidermal cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143476,DTL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.459225,-0.25877,-0.509856
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 48.0144% (minimum 99%, Missing); colon: 80.6061% (minimum 90%, Supported); duodenum: 85.8065% (minimum 97%, Supported); esophagus: 87.5000% (minimum 97%, Missing); liver: 91.7241% (minimum 97%, Supported); lung: 90.4762% (minimum 99%, Missing); lymph node: 71.1230% (minimum 97%, Missing); pituitary gland: 98.5185% (minimum 99%, Missing); rectum: 74.3017% (minimum 90%, Supported); skin: 86.3636% (minimum 95%, Missing); small intestine: 82.0988% (minimum 97%, Supported); smooth muscle: 88.0795% (minimum 99%, Missing); thymus: 49.0775% (minimum 95%, Missing)",0,2,partial,14.4,5.4,13.8,"bone marrow: 14.4 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); lymph node: 5.4 nTPM (protected, limit 2); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); skin 2 / epidermal cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143476,DTL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.459225,-0.25877,-0.509856
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.7,7.2,8.1,"bone marrow: 8.7 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 2); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); esophagus: 2.7 nTPM (protected, limit 2); hippocampal formation: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143479,DYRK3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.4312% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.2869% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.8763% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.0744% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.2391% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.5169% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.8980% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.1648% (minimum 99%, Baseline (adaptation disabled)); colon: 95.2869% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.8947% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.5122% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.3211% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.5122% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.8980% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.5614% (minimum 99%, Baseline (adaptation disabled)); liver: 92.0792% (minimum 99%, Baseline (adaptation disabled)); lung: 89.7683% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.6736% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.0772% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.6295% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.1296% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.0682% (minimum 99%, Baseline (adaptation disabled)); retina: 88.2353% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.8972% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.3087% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.4730% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.4779% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.1013% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.9394% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.9101% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.1648% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.2733% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.5922% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.7,7.2,8.1,"bone marrow: 8.7 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 2); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); esophagus: 2.7 nTPM (protected, limit 2); hippocampal formation: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143479,DYRK3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0983516,-0.104078,-0.147609
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.4312% (minimum 95%, Missing); adrenal gland: 95.2869% (minimum 99%, Missing); amygdala: 95.8763% (minimum 99%, Missing); basal ganglia: 96.0744% (minimum 99%, Missing); bone marrow: 84.2391% (minimum 99%, Missing); cerebellum: 98.5169% (minimum 99%, Missing); cerebral cortex: 94.8980% (minimum 99%, Missing); choroid plexus: 85.1648% (minimum 99%, Missing); colon: 95.2869% (minimum 97%, Missing); duodenum: 97.8947% (minimum 99%, Missing); esophagus: 94.5122% (minimum 97%, Missing); heart muscle: 85.3211% (minimum 99%, Missing); hippocampal formation: 94.5122% (minimum 99%, Missing); hypothalamus: 94.8980% (minimum 99%, Missing); kidney: 93.5614% (minimum 99%, Missing); liver: 92.0792% (minimum 99%, Missing); lung: 89.7683% (minimum 99%, Missing); lymph node: 96.6736% (minimum 97%, Missing); midbrain: 97.0772% (minimum 99%, Missing); pancreas: 92.6295% (minimum 99%, Missing); parathyroid gland: 94.1296% (minimum 97%, Missing); pituitary gland: 88.0682% (minimum 99%, Missing); retina: 88.2353% (minimum 99%, Missing); salivary gland: 91.8972% (minimum 97%, Missing); skeletal muscle: 98.3087% (minimum 99%, Missing); small intestine: 96.4730% (minimum 99%, Missing); smooth muscle: 85.4779% (minimum 99%, Missing); spinal cord: 98.1013% (minimum 99%, Missing); stomach: 93.9394% (minimum 97%, Missing); thymus: 88.9101% (minimum 95%, Missing); thyroid gland: 85.1648% (minimum 95%, Missing); tongue: 96.2733% (minimum 97%, Missing); urinary bladder: 86.5922% (minimum 97%, Missing)",0,80,unavailable,8.7,7.2,8.1,"bone marrow: 8.7 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 2); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); esophagus: 2.7 nTPM (protected, limit 2); hippocampal formation: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143479,DYRK3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0983516,-0.104078,-0.147609
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.5,3.9,4.1,"esophagus: 3.9 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143494,VASH2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 82.7957% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.7179% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.7711% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.5349% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.2500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.5882% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.4684% (minimum 99%, Baseline (adaptation disabled)); colon: 93.9024% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.3793% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.0617% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.7711% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.2500% (minimum 99%, Baseline (adaptation disabled)); liver: 97.4684% (minimum 99%, Baseline (adaptation disabled)); lung: 88.5057% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.7778% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.2500% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.4684% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.5882% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.4902% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.7711% (minimum 97%, Baseline (adaptation disabled)); retina: 93.9024% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.5882% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.9024% (minimum 99%, Baseline (adaptation disabled)); small intestine: 90.5882% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.9149% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4684% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.5169% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.2542% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.5882% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.6154% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.5,3.9,4.1,"esophagus: 3.9 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143494,VASH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.297458,-0.306207,-0.235098
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 82.7957% (minimum 95%, Missing); adrenal gland: 98.7179% (minimum 99%, Missing); amygdala: 92.7711% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 89.5349% (minimum 99%, Missing); cerebellum: 96.2500% (minimum 99%, Missing); cerebral cortex: 90.5882% (minimum 99%, Missing); choroid plexus: 97.4684% (minimum 99%, Missing); colon: 93.9024% (minimum 97%, Missing); duodenum: 91.6667% (minimum 99%, Missing); esophagus: 66.3793% (minimum 97%, Missing); heart muscle: 87.5000% (minimum 99%, Missing); hippocampal formation: 95.0617% (minimum 99%, Missing); hypothalamus: 92.7711% (minimum 99%, Missing); kidney: 96.2500% (minimum 99%, Missing); liver: 97.4684% (minimum 99%, Missing); lung: 88.5057% (minimum 99%, Missing); lymph node: 77.7778% (minimum 97%, Missing); midbrain: 96.2500% (minimum 99%, Missing); pancreas: 97.4684% (minimum 99%, Missing); parathyroid gland: 90.5882% (minimum 97%, Missing); pituitary gland: 75.4902% (minimum 99%, Missing); rectum: 92.7711% (minimum 97%, Missing); retina: 93.9024% (minimum 99%, Missing); salivary gland: 90.5882% (minimum 97%, Missing); skeletal muscle: 93.9024% (minimum 99%, Missing); small intestine: 90.5882% (minimum 99%, Missing); smooth muscle: 81.9149% (minimum 99%, Missing); spinal cord: 97.4684% (minimum 99%, Missing); spleen: 86.5169% (minimum 95%, Missing); stomach: 91.6667% (minimum 97%, Missing); thymus: 65.2542% (minimum 95%, Missing); tongue: 90.5882% (minimum 97%, Missing); urinary bladder: 84.6154% (minimum 97%, Missing)",0,80,unavailable,2.5,3.9,4.1,"esophagus: 3.9 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000143494,VASH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.297458,-0.306207,-0.235098
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,3.9,6.3,4.9,"lymph node: 6.3 nTPM (protected, limit 2); urinary bladder: 5.1 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143498,TAF1A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.7778% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.8936% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.2632% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.2051% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.3182% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.2152% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.0330% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.5616% (minimum 99%, Baseline (adaptation disabled)); colon: 75.3086% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.7647% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.9302% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.2152% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.3902% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.3086% (minimum 99%, Baseline (adaptation disabled)); liver: 77.2152% (minimum 99%, Baseline (adaptation disabled)); lung: 69.3182% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.1935% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.2051% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.2500% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.2152% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.7647% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.9302% (minimum 97%, Baseline (adaptation disabled)); retina: 61.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.2500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.5616% (minimum 99%, Baseline (adaptation disabled)); skin: 75.3086% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.6190% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.7647% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.3086% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.6538% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.8936% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.6538% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.4545% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.4324% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.4643% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,3.9,6.3,4.9,"lymph node: 6.3 nTPM (protected, limit 2); urinary bladder: 5.1 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143498,TAF1A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.395455,-0.478065,-0.38
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.7778% (minimum 90%, Approved); adrenal gland: 64.8936% (minimum 99%, Missing); amygdala: 80.2632% (minimum 99%, Missing); basal ganglia: 78.2051% (minimum 99%, Missing); bone marrow: 69.3182% (minimum 99%, Missing); cerebellum: 77.2152% (minimum 99%, Missing); cerebral cortex: 67.0330% (minimum 99%, Missing); choroid plexus: 83.5616% (minimum 99%, Missing); colon: 75.3086% (minimum 97%, Missing); duodenum: 71.7647% (minimum 99%, Missing); esophagus: 70.9302% (minimum 97%, Missing); heart muscle: 77.2152% (minimum 99%, Missing); hippocampal formation: 81.3333% (minimum 99%, Missing); hypothalamus: 74.3902% (minimum 99%, Missing); kidney: 75.3086% (minimum 99%, Missing); liver: 77.2152% (minimum 99%, Missing); lung: 69.3182% (minimum 99%, Missing); lymph node: 49.1935% (minimum 97%, Missing); midbrain: 78.2051% (minimum 99%, Missing); pancreas: 76.2500% (minimum 99%, Missing); parathyroid gland: 77.2152% (minimum 97%, Missing); pituitary gland: 71.7647% (minimum 99%, Missing); rectum: 70.9302% (minimum 97%, Missing); retina: 61.0000% (minimum 99%, Missing); salivary gland: 76.2500% (minimum 97%, Missing); skeletal muscle: 83.5616% (minimum 99%, Missing); skin: 75.3086% (minimum 95%, Missing); small intestine: 72.6190% (minimum 99%, Missing); smooth muscle: 71.7647% (minimum 99%, Missing); spinal cord: 75.3086% (minimum 99%, Missing); spleen: 58.6538% (minimum 95%, Missing); stomach: 64.8936% (minimum 97%, Missing); thymus: 58.6538% (minimum 95%, Missing); thyroid gland: 55.4545% (minimum 95%, Missing); tongue: 82.4324% (minimum 97%, Missing); urinary bladder: 54.4643% (minimum 97%, Missing)",0,5,partial,3.9,6.3,4.9,"lymph node: 6.3 nTPM (protected, limit 2); urinary bladder: 5.1 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143498,TAF1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.395455,-0.478065,-0.38
True,compatible,,True,True,False,,0,2,partial,0.3,1,1.9,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000143512,HHIPL2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.0000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.9167% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.9167% (minimum 99%, Baseline (adaptation disabled)); retina: 97.9167% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.4561% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 71.2121% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,0.3,1,1.9,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000143512,HHIPL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.237879,-0.145439,-0.05
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.0000% (minimum 95%, Enhanced); pituitary gland: 97.9167% (minimum 99%, Missing); retina: 97.9167% (minimum 99%, Missing)",0,2,partial,0.3,1,1.9,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000143512,HHIPL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0245614,-0.0108333
True,compatible,,True,True,False,,0,2,partial,0.6,0.3,0.2,,,52,not_established,not_triggered,,,ENSG00000143552,NUP210L,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 97.7273% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.8506% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4733% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.6,0.3,0.2,,,52,not_established,not_triggered,,,ENSG00000143552,NUP210L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0423077,0.0185057,-0.0127273
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 97.7273% (minimum 99%, Missing); pituitary gland: 98.8506% (minimum 99%, Missing); retina: 98.4733% (minimum 99%, Missing)",0,2,partial,0.6,0.3,0.2,,,52,not_established,not_triggered,,,ENSG00000143552,NUP210L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0127273
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,52,6.3,12,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (manageable, limit 5); retina: 10.6 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); heart muscle: 7.2 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); basal ganglia: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); lymph node: 6.3 nTPM (protected, limit 2); urinary bladder: 6.3 nTPM (protected, limit 2); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 2); colon: 5.3 nTPM (protected, limit 2); adrenal gland: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000143702,CEP170,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.7981% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.6855% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.0704% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.0704% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 62.6705% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.0161% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.7812% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.6777% (minimum 99%, Baseline (adaptation disabled)); colon: 94.2765% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.6777% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.8913% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.3810% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.7981% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.8429% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.1079% (minimum 99%, Baseline (adaptation disabled)); liver: 93.3690% (minimum 99%, Baseline (adaptation disabled)); lung: 91.3180% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.2692% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7604% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.4098% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.7849% (minimum 97%, Baseline (adaptation disabled)); retina: 89.1726% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0396% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.8148% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.4098% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.5691% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.6486% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.9712% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.4641% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.2638% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.9154% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.9720% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 93.2692% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,52,6.3,12,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (manageable, limit 5); retina: 10.6 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); heart muscle: 7.2 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); basal ganglia: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); lymph node: 6.3 nTPM (protected, limit 2); urinary bladder: 6.3 nTPM (protected, limit 2); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 2); colon: 5.3 nTPM (protected, limit 2); adrenal gland: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000143702,CEP170,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0708459,-0.0373077,-0.363295
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.7981% (minimum 95%, Uncertain); adrenal gland: 94.6855% (minimum 99%, Uncertain); amygdala: 93.0704% (minimum 99%, Missing); basal ganglia: 93.0704% (minimum 99%, Missing); bone marrow: 62.6705% (minimum 99%, Uncertain); cerebellum: 78.0161% (minimum 99%, Uncertain); cerebral cortex: 83.7812% (minimum 99%, Missing); choroid plexus: 96.6777% (minimum 99%, Missing); colon: 94.2765% (minimum 97%, Missing); duodenum: 96.6777% (minimum 99%, Missing); esophagus: 94.8913% (minimum 97%, Uncertain); heart muscle: 92.3810% (minimum 99%, Uncertain); hippocampal formation: 91.7981% (minimum 99%, Missing); hypothalamus: 90.8429% (minimum 99%, Missing); kidney: 97.1079% (minimum 99%, Uncertain); liver: 93.3690% (minimum 99%, Uncertain); lung: 91.3180% (minimum 99%, Missing); lymph node: 93.2692% (minimum 97%, Uncertain); midbrain: 90.0000% (minimum 99%, Missing); pancreas: 97.7604% (minimum 99%, Missing); pituitary gland: 95.4098% (minimum 99%, Missing); rectum: 96.7849% (minimum 97%, Missing); retina: 89.1726% (minimum 99%, Missing); salivary gland: 96.0396% (minimum 97%, Missing); skeletal muscle: 89.8148% (minimum 99%, Missing); small intestine: 95.4098% (minimum 99%, Missing); smooth muscle: 93.5691% (minimum 99%, Uncertain); spinal cord: 78.6486% (minimum 99%, Missing); spleen: 92.9712% (minimum 95%, Uncertain); stomach: 96.4641% (minimum 97%, Missing); thymus: 89.2638% (minimum 95%, Missing); thyroid gland: 87.9154% (minimum 95%, Missing); tongue: 93.9720% (minimum 97%, Missing); urinary bladder: 93.2692% (minimum 97%, Uncertain)",0,5,partial,52,6.3,12,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (manageable, limit 5); retina: 10.6 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); heart muscle: 7.2 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); basal ganglia: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); lymph node: 6.3 nTPM (protected, limit 2); urinary bladder: 6.3 nTPM (protected, limit 2); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 2); colon: 5.3 nTPM (protected, limit 2); adrenal gland: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000143702,CEP170,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0708459,-0.0373077,-0.363295
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,32.4,12.1,22.2,"bone marrow: 32.4 nTPM (vital, limit 1); thymus: 22.2 nTPM (manageable, limit 5); adipose tissue: 16.9 nTPM (manageable, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); lymph node: 12.1 nTPM (protected, limit 2); urinary bladder: 11.2 nTPM (protected, limit 2); parathyroid gland: 10.8 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); spleen: 10.1 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 2); tongue: 9.3 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 2); stomach: 7.5 nTPM (protected, limit 2); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); salivary gland: 6.5 nTPM (protected, limit 2); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143751,SDE2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 40.2827% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.8680% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.4556% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.9387% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 26.0274% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.0769% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.2951% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 58.7629% (minimum 97%, Baseline (adaptation disabled)); duodenum: 56.7164% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.0725% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.6383% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.4556% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.0588% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.1576% (minimum 99%, Baseline (adaptation disabled)); liver: 44.7059% (minimum 99%, Baseline (adaptation disabled)); lung: 56.1576% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.5106% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.0725% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.3514% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.0769% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.4356% (minimum 97%, Baseline (adaptation disabled)); retina: 69.9387% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.6872% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 48.1013% (minimum 99%, Baseline (adaptation disabled)); skin: 52.2936% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.7164% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 54.8077% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.9565% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.0233% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.3175% (minimum 97%, Baseline (adaptation disabled)); thymus: 33.9286% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.5106% (minimum 95%, Baseline (adaptation disabled)); tongue: 55.0725% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.4425% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,32.4,12.1,22.2,"bone marrow: 32.4 nTPM (vital, limit 1); thymus: 22.2 nTPM (manageable, limit 5); adipose tissue: 16.9 nTPM (manageable, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); lymph node: 12.1 nTPM (protected, limit 2); urinary bladder: 11.2 nTPM (protected, limit 2); parathyroid gland: 10.8 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); spleen: 10.1 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 2); tongue: 9.3 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 2); stomach: 7.5 nTPM (protected, limit 2); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); salivary gland: 6.5 nTPM (protected, limit 2); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143751,SDE2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.610714,-0.484894,-0.729726
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 40.2827% (minimum 95%, Missing); adrenal gland: 57.8680% (minimum 99%, Missing); amygdala: 67.4556% (minimum 99%, Missing); basal ganglia: 69.9387% (minimum 99%, Missing); bone marrow: 26.0274% (minimum 99%, Missing); cerebellum: 73.0769% (minimum 99%, Missing); cerebral cortex: 62.2951% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 58.7629% (minimum 97%, Missing); duodenum: 56.7164% (minimum 99%, Missing); esophagus: 55.0725% (minimum 97%, Missing); heart muscle: 60.6383% (minimum 99%, Missing); hippocampal formation: 67.4556% (minimum 99%, Missing); hypothalamus: 67.0588% (minimum 99%, Missing); kidney: 56.1576% (minimum 99%, Missing); liver: 44.7059% (minimum 99%, Missing); lung: 56.1576% (minimum 99%, Missing); lymph node: 48.5106% (minimum 97%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 55.0725% (minimum 99%, Missing); parathyroid gland: 51.3514% (minimum 97%, Missing); pituitary gland: 73.0769% (minimum 99%, Missing); rectum: 56.4356% (minimum 97%, Missing); retina: 69.9387% (minimum 99%, Missing); salivary gland: 63.6872% (minimum 97%, Missing); skeletal muscle: 48.1013% (minimum 99%, Missing); skin: 52.2936% (minimum 95%, Missing); small intestine: 56.7164% (minimum 99%, Missing); smooth muscle: 54.8077% (minimum 99%, Missing); spinal cord: 61.9565% (minimum 99%, Missing); spleen: 53.0233% (minimum 95%, Missing); stomach: 60.3175% (minimum 97%, Missing); thymus: 33.9286% (minimum 95%, Missing); thyroid gland: 48.5106% (minimum 95%, Missing); tongue: 55.0725% (minimum 97%, Missing); urinary bladder: 50.4425% (minimum 97%, Missing)",0,1,partial,32.4,12.1,22.2,"bone marrow: 32.4 nTPM (vital, limit 1); thymus: 22.2 nTPM (manageable, limit 5); adipose tissue: 16.9 nTPM (manageable, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); lymph node: 12.1 nTPM (protected, limit 2); urinary bladder: 11.2 nTPM (protected, limit 2); parathyroid gland: 10.8 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); spleen: 10.1 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 2); tongue: 9.3 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 2); stomach: 7.5 nTPM (protected, limit 2); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); salivary gland: 6.5 nTPM (protected, limit 2); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143751,SDE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.610714,-0.484894,-0.729726
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,11.5,3.2,4.4,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); tongue: 2.8 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143951,WDPCP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.2278% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.6970% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.6555% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.9661% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.4884% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 51.6854% (minimum 99%, Baseline (adaptation disabled)); colon: 76.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.1935% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.8750% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.0159% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.1935% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.2278% (minimum 99%, Baseline (adaptation disabled)); liver: 67.6471% (minimum 99%, Baseline (adaptation disabled)); lung: 65.7143% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.7403% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.1622% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.7692% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.1935% (minimum 97%, Baseline (adaptation disabled)); retina: 28.5714% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.6970% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 48.9362% (minimum 99%, Baseline (adaptation disabled)); skin: 59.7403% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.4098% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.1622% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.6567% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.7403% (minimum 95%, Baseline (adaptation disabled)); stomach: 58.9744% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.5000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.9744% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.1622% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.0159% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,11.5,3.2,4.4,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); tongue: 2.8 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143951,WDPCP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.438889,-0.380256,-0.704286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 95%, Missing); adrenal gland: 58.2278% (minimum 99%, Uncertain); amygdala: 76.6667% (minimum 99%, Missing); basal ganglia: 69.6970% (minimum 99%, Missing); bone marrow: 38.6555% (minimum 99%, Uncertain); cerebellum: 77.9661% (minimum 99%, Missing); cerebral cortex: 53.4884% (minimum 99%, Missing); choroid plexus: 51.6854% (minimum 99%, Missing); colon: 76.6667% (minimum 97%, Missing); duodenum: 74.1935% (minimum 99%, Missing); esophagus: 71.8750% (minimum 97%, Missing); heart muscle: 50.0000% (minimum 99%, Missing); hippocampal formation: 73.0159% (minimum 99%, Missing); hypothalamus: 74.1935% (minimum 99%, Missing); kidney: 58.2278% (minimum 99%, Missing); liver: 67.6471% (minimum 99%, Uncertain); lung: 65.7143% (minimum 99%, Missing); lymph node: 59.7403% (minimum 97%, Missing); midbrain: 76.6667% (minimum 99%, Missing); pancreas: 76.6667% (minimum 99%, Missing); parathyroid gland: 62.1622% (minimum 97%, Missing); pituitary gland: 70.7692% (minimum 99%, Missing); rectum: 74.1935% (minimum 97%, Missing); retina: 28.5714% (minimum 99%, Missing); salivary gland: 69.6970% (minimum 97%, Missing); skeletal muscle: 48.9362% (minimum 99%, Missing); skin: 59.7403% (minimum 95%, Missing); small intestine: 75.4098% (minimum 99%, Missing); smooth muscle: 62.1622% (minimum 99%, Uncertain); spinal cord: 68.6567% (minimum 99%, Missing); spleen: 59.7403% (minimum 95%, Uncertain); stomach: 58.9744% (minimum 97%, Missing); thymus: 57.5000% (minimum 95%, Missing); thyroid gland: 58.9744% (minimum 95%, Missing); tongue: 62.1622% (minimum 97%, Missing); urinary bladder: 73.0159% (minimum 97%, Uncertain)",0,3,partial,11.5,3.2,4.4,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); tongue: 2.8 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143951,WDPCP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.438889,-0.380256,-0.704286
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,3.2,1.6,1.1,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143994,ABHD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.2222% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.1308% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2222% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.6744% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.6744% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5915% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.5915% (minimum 99%, Baseline (adaptation disabled)); liver: 86.7769% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.1308% (minimum 99%, Baseline (adaptation disabled)); retina: 98.1308% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.7500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.1053% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5915% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5915% (minimum 99%, Baseline (adaptation disabled)); tongue: 92.9204% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,3.2,1.6,1.1,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143994,ABHD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,0.000226244,-0.0407965,-0.122231
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.2222% (minimum 99%, Missing); amygdala: 98.1308% (minimum 99%, Missing); basal ganglia: 97.2222% (minimum 99%, Missing); cerebral cortex: 97.6744% (minimum 99%, Missing); heart muscle: 97.6744% (minimum 99%, Missing); hippocampal formation: 98.5915% (minimum 99%, Missing); kidney: 98.5915% (minimum 99%, Missing); liver: 86.7769% (minimum 99%, Missing); midbrain: 98.1308% (minimum 99%, Missing); retina: 98.1308% (minimum 99%, Missing); salivary gland: 93.7500% (minimum 97%, Missing); skeletal muscle: 92.1053% (minimum 99%, Missing); smooth muscle: 98.5915% (minimum 99%, Missing); spinal cord: 98.5915% (minimum 99%, Missing); tongue: 92.9204% (minimum 97%, Missing)",0,6,partial,3.2,1.6,1.1,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000143994,ABHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,0.000226244,-0.0407965,-0.122231
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000144010,TRIM43B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000144010,TRIM43B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.45,0.03,-0.24
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"cerebral cortex: 75.0000% (minimum 99%, Missing); thymus: 50.0000% (minimum 95%, Missing)",0,80,unavailable,0.1,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000144010,TRIM43B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.45,0.03,-0.24
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000144015,TRIM43,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); stomach: 60.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000144015,TRIM43,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.45,-0.37,-0.24
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 75.0000% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); stomach: 60.0000% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing)",0,80,unavailable,0.1,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000144015,TRIM43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.45,-0.37,-0.24
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,37.1,16.4,7.2,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 4); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 2); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144061,NPHP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.9299% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.0036% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.1034% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.4920% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.0159% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.8592% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 39.3791% (minimum 99%, Baseline (adaptation disabled)); colon: 82.5342% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.4000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.8819% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.6806% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.4189% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.2658% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.5486% (minimum 99%, Baseline (adaptation disabled)); liver: 96.7871% (minimum 99%, Baseline (adaptation disabled)); lung: 85.1590% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.7871% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.3799% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.6029% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.5062% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.8873% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.4109% (minimum 97%, Baseline (adaptation disabled)); retina: 69.8551% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.9434% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 40.7783% (minimum 99%, Baseline (adaptation disabled)); skin: 93.4109% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.0502% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.2657% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.0036% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.0502% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.3188% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 76.9968% (minimum 95%, Baseline (adaptation disabled)); tongue: 70.0581% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.7651% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,37.1,16.4,7.2,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 2); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 2); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144061,NPHP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.180032,-0.374938,-0.596209
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.9299% (minimum 90%, Approved); adrenal gland: 87.0036% (minimum 99%, Missing); amygdala: 83.1034% (minimum 99%, Missing); basal ganglia: 77.4920% (minimum 99%, Missing); cerebellum: 96.0159% (minimum 99%, Missing); cerebral cortex: 84.8592% (minimum 99%, Missing); choroid plexus: 39.3791% (minimum 99%, Missing); colon: 82.5342% (minimum 97%, Missing); duodenum: 96.4000% (minimum 99%, Missing); esophagus: 94.8819% (minimum 97%, Missing); heart muscle: 83.6806% (minimum 99%, Missing); hippocampal formation: 81.4189% (minimum 99%, Missing); hypothalamus: 76.2658% (minimum 99%, Missing); kidney: 75.5486% (minimum 99%, Missing); liver: 96.7871% (minimum 99%, Missing); lung: 85.1590% (minimum 99%, Missing); lymph node: 96.7871% (minimum 97%, Missing); midbrain: 86.3799% (minimum 99%, Missing); pancreas: 88.6029% (minimum 99%, Missing); parathyroid gland: 59.5062% (minimum 95%, Approved); pituitary gland: 67.8873% (minimum 99%, Missing); rectum: 93.4109% (minimum 97%, Missing); retina: 69.8551% (minimum 99%, Missing); salivary gland: 90.9434% (minimum 97%, Missing); skeletal muscle: 40.7783% (minimum 99%, Missing); skin: 93.4109% (minimum 95%, Missing); small intestine: 93.0502% (minimum 99%, Missing); smooth muscle: 84.2657% (minimum 99%, Missing); spinal cord: 87.0036% (minimum 99%, Missing); spleen: 93.0502% (minimum 95%, Missing); stomach: 87.3188% (minimum 97%, Missing); thyroid gland: 76.9968% (minimum 95%, Missing); tongue: 70.0581% (minimum 97%, Missing); urinary bladder: 85.7651% (minimum 97%, Missing)",0,4,partial,37.1,16.4,7.2,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 4); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 2); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144061,NPHP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.180032,-0.354938,-0.596209
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.2,0.8,0.3,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,ENSG00000144130,NT5DC4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.5676% (minimum 99%, Baseline (adaptation disabled)); lung: 96.1538% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.7576% (minimum 97%, Baseline (adaptation disabled)); small intestine: 96.1538% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.2857% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.2,0.8,0.3,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,ENSG00000144130,NT5DC4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.0571429,-0.212424,-0.314324
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.5676% (minimum 99%, Missing); lung: 96.1538% (minimum 99%, Missing); lymph node: 75.7576% (minimum 97%, Missing); small intestine: 96.1538% (minimum 99%, Missing); spleen: 89.2857% (minimum 95%, Missing)",0,80,unavailable,1.2,0.8,0.3,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,ENSG00000144130,NT5DC4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.0571429,-0.212424,-0.314324
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,12.2,10.4,11.6,"bone marrow: 12.2 nTPM (vital, limit 2); spleen: 11.6 nTPM (manageable, limit 10); thyroid gland: 11 nTPM (manageable, limit 10); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 4); skeletal muscle: 8.8 nTPM (vital, limit 1); salivary gland: 8.7 nTPM (protected, limit 4); tongue: 8.6 nTPM (protected, limit 2); heart muscle: 8.2 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 2); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 2); pancreas: 7 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (manageable, limit 5); midbrain: 6.9 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); stomach: 6.7 nTPM (protected, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); parathyroid gland: 6.1 nTPM (protected, limit 4); basal ganglia: 6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 2); smooth muscle: 5.4 nTPM (vital, limit 2); cerebellum: 5.4 nTPM (vital, limit 2); amygdala: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 4); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000144182,LIPT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 66.5049% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.6226% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.1053% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.5431% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.8958% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 71.7277% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.8634% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.8409% (minimum 99%, Baseline (adaptation disabled)); colon: 67.8218% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.8440% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.6559% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.5571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 69.5431% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.4868% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.6911% (minimum 99%, Baseline (adaptation disabled)); liver: 63.4259% (minimum 99%, Baseline (adaptation disabled)); lung: 71.3542% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.8465% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.5049% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.1836% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.1919% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.8218% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.1836% (minimum 97%, Baseline (adaptation disabled)); retina: 65.2381% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.1607% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.8889% (minimum 99%, Baseline (adaptation disabled)); skin: 66.8293% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.8440% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.7277% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.5502% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.1502% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.1569% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.4868% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.4656% (minimum 95%, Baseline (adaptation disabled)); tongue: 61.4350% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.1919% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,12.2,10.4,11.6,"bone marrow: 12.2 nTPM (vital, limit 1); spleen: 11.6 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 2); skeletal muscle: 8.8 nTPM (vital, limit 1); salivary gland: 8.7 nTPM (protected, limit 2); tongue: 8.6 nTPM (protected, limit 2); heart muscle: 8.2 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 2); pancreas: 7 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (manageable, limit 5); midbrain: 6.9 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); stomach: 6.7 nTPM (protected, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); parathyroid gland: 6.1 nTPM (protected, limit 2); basal ganglia: 6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000144182,LIPT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.408498,-0.401535,-0.461042
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 66.5049% (minimum 95%, Missing); adrenal gland: 64.6226% (minimum 99%, Missing); amygdala: 72.1053% (minimum 99%, Missing); basal ganglia: 69.5431% (minimum 99%, Missing); bone marrow: 52.8958% (minimum 98%, Approved); cerebellum: 71.7277% (minimum 98%, Approved); cerebral cortex: 74.8634% (minimum 99%, Missing); choroid plexus: 77.8409% (minimum 99%, Missing); colon: 67.8218% (minimum 97%, Missing); duodenum: 62.8440% (minimum 99%, Missing); esophagus: 73.6559% (minimum 95%, Approved); heart muscle: 62.5571% (minimum 99%, Missing); hippocampal formation: 69.5431% (minimum 99%, Missing); hypothalamus: 72.4868% (minimum 99%, Missing); kidney: 55.6911% (minimum 99%, Missing); liver: 63.4259% (minimum 99%, Missing); lung: 71.3542% (minimum 98%, Approved); lymph node: 56.8465% (minimum 95%, Approved); midbrain: 66.5049% (minimum 99%, Missing); pancreas: 66.1836% (minimum 99%, Missing); parathyroid gland: 69.1919% (minimum 95%, Approved); pituitary gland: 67.8218% (minimum 99%, Missing); rectum: 66.1836% (minimum 97%, Missing); retina: 65.2381% (minimum 99%, Missing); salivary gland: 61.1607% (minimum 95%, Approved); skeletal muscle: 60.8889% (minimum 99%, Missing); skin: 66.8293% (minimum 95%, Missing); small intestine: 62.8440% (minimum 98%, Approved); smooth muscle: 71.7277% (minimum 98%, Approved); spinal cord: 65.5502% (minimum 99%, Missing); spleen: 54.1502% (minimum 90%, Approved); stomach: 67.1569% (minimum 97%, Missing); thymus: 72.4868% (minimum 95%, Missing); thyroid gland: 55.4656% (minimum 90%, Approved); tongue: 61.4350% (minimum 97%, Missing); urinary bladder: 69.1919% (minimum 97%, Missing)",0,7,partial,12.2,10.4,11.6,"bone marrow: 12.2 nTPM (vital, limit 2); spleen: 11.6 nTPM (manageable, limit 10); thyroid gland: 11 nTPM (manageable, limit 10); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 4); skeletal muscle: 8.8 nTPM (vital, limit 1); salivary gland: 8.7 nTPM (protected, limit 4); tongue: 8.6 nTPM (protected, limit 2); heart muscle: 8.2 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 2); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 2); pancreas: 7 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (manageable, limit 5); midbrain: 6.9 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); stomach: 6.7 nTPM (protected, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); parathyroid gland: 6.1 nTPM (protected, limit 4); basal ganglia: 6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 2); smooth muscle: 5.4 nTPM (vital, limit 2); cerebellum: 5.4 nTPM (vital, limit 2); amygdala: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 4); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000144182,LIPT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.358498,-0.381535,-0.451042
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.5,0.2,1,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000144395,CCDC150,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.9592% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.8889% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.9592% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.9592% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.9592% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.7534% (minimum 99%, Baseline (adaptation disabled)); liver: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.9592% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.9592% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.9592% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.0000% (minimum 99%, Baseline (adaptation disabled)); thymus: 82.7586% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2.5,0.2,1,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000144395,CCDC150,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.122414,-0.01,-0.332466
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.9592% (minimum 99%, Missing); basal ganglia: 96.0000% (minimum 99%, Missing); bone marrow: 88.8889% (minimum 99%, Missing); duodenum: 97.9592% (minimum 99%, Missing); hippocampal formation: 97.9592% (minimum 99%, Missing); hypothalamus: 97.9592% (minimum 99%, Missing); kidney: 65.7534% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lymph node: 96.0000% (minimum 97%, Missing); midbrain: 97.9592% (minimum 99%, Missing); rectum: 96.0000% (minimum 97%, Missing); skeletal muscle: 97.9592% (minimum 99%, Missing); small intestine: 97.9592% (minimum 99%, Missing); spinal cord: 96.0000% (minimum 99%, Missing); thymus: 82.7586% (minimum 95%, Missing)",0,80,unavailable,2.5,0.2,1,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000144395,CCDC150,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.122414,-0.01,-0.332466
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,23.1,16,17.2,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); thymus: 17.2 nTPM (manageable, limit 5); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 2); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); spleen: 14.4 nTPM (manageable, limit 5); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 2); adipose tissue: 9.8 nTPM (manageable, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 2); colon: 8.9 nTPM (protected, limit 2); adrenal gland: 8.7 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 2); pancreas: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 2); urinary bladder: 8.2 nTPM (protected, limit 2); lung: 8 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 2); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); esophagus: 6.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144401,METTL21A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.6296% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.5610% (minimum 99%, Baseline (adaptation disabled)); amygdala: 42.4460% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 40.1361% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 34.8083% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 47.7733% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 40.8304% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 45.5598% (minimum 99%, Baseline (adaptation disabled)); colon: 57.0048% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.4339% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.4809% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 47.2000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 44.0299% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 43.2234% (minimum 99%, Baseline (adaptation disabled)); kidney: 51.9824% (minimum 99%, Baseline (adaptation disabled)); liver: 33.8109% (minimum 99%, Baseline (adaptation disabled)); lung: 59.5960% (minimum 99%, Baseline (adaptation disabled)); lymph node: 42.4460% (minimum 97%, Baseline (adaptation disabled)); midbrain: 38.5621% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.8431% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.3991% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.1402% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.8431% (minimum 97%, Baseline (adaptation disabled)); retina: 45.3846% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.2041% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 44.0299% (minimum 99%, Baseline (adaptation disabled)); skin: 73.7500% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.8431% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.4583% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 37.3418% (minimum 99%, Baseline (adaptation disabled)); spleen: 45.0382% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.6786% (minimum 97%, Baseline (adaptation disabled)); thymus: 40.6897% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 49.7890% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.1281% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.0000% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,23.1,16,17.2,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); thymus: 17.2 nTPM (manageable, limit 5); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 2); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); spleen: 14.4 nTPM (manageable, limit 5); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 2); adipose tissue: 9.8 nTPM (manageable, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 2); colon: 8.9 nTPM (protected, limit 2); adrenal gland: 8.7 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 2); pancreas: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 2); urinary bladder: 8.2 nTPM (protected, limit 2); lung: 8 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 2); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); esophagus: 6.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144401,METTL21A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.543103,-0.54554,-0.651891
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.6296% (minimum 95%, Missing); adrenal gland: 57.5610% (minimum 99%, Missing); amygdala: 42.4460% (minimum 99%, Missing); basal ganglia: 40.1361% (minimum 99%, Missing); bone marrow: 34.8083% (minimum 99%, Missing); cerebellum: 47.7733% (minimum 99%, Missing); cerebral cortex: 40.8304% (minimum 99%, Missing); choroid plexus: 45.5598% (minimum 99%, Missing); colon: 57.0048% (minimum 97%, Missing); duodenum: 62.4339% (minimum 99%, Missing); esophagus: 64.4809% (minimum 97%, Missing); heart muscle: 47.2000% (minimum 99%, Missing); hippocampal formation: 44.0299% (minimum 99%, Missing); hypothalamus: 43.2234% (minimum 99%, Missing); kidney: 51.9824% (minimum 99%, Missing); liver: 33.8109% (minimum 99%, Missing); lung: 59.5960% (minimum 99%, Missing); lymph node: 42.4460% (minimum 97%, Missing); midbrain: 38.5621% (minimum 99%, Missing); pancreas: 57.8431% (minimum 99%, Missing); parathyroid gland: 55.3991% (minimum 97%, Uncertain); pituitary gland: 55.1402% (minimum 99%, Missing); rectum: 57.8431% (minimum 97%, Missing); retina: 45.3846% (minimum 99%, Missing); salivary gland: 60.2041% (minimum 97%, Missing); skeletal muscle: 44.0299% (minimum 99%, Uncertain); skin: 73.7500% (minimum 95%, Missing); small intestine: 57.8431% (minimum 99%, Missing); smooth muscle: 61.4583% (minimum 99%, Missing); spinal cord: 37.3418% (minimum 99%, Missing); spleen: 45.0382% (minimum 95%, Missing); stomach: 52.6786% (minimum 97%, Missing); thymus: 40.6897% (minimum 95%, Missing); thyroid gland: 49.7890% (minimum 95%, Missing); tongue: 58.1281% (minimum 97%, Missing); urinary bladder: 59.0000% (minimum 97%, Missing)",0,1,partial,23.1,16,17.2,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); thymus: 17.2 nTPM (manageable, limit 5); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 2); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); spleen: 14.4 nTPM (manageable, limit 5); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 2); adipose tissue: 9.8 nTPM (manageable, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 2); colon: 8.9 nTPM (protected, limit 2); adrenal gland: 8.7 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 2); pancreas: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 2); urinary bladder: 8.2 nTPM (protected, limit 2); lung: 8 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 2); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); esophagus: 6.5 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144401,METTL21A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.543103,-0.54554,-0.651891
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,21.9,192.4,26,"parathyroid gland: 192.4 nTPM (protected, limit 2); thymus: 26 nTPM (manageable, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); tongue: 17.7 nTPM (protected, limit 2); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 2); skin: 12.9 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 2); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); rectum: 6.6 nTPM (protected, limit 2); small intestine: 6.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144445,KANSL1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 68.7151% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.4601% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.7276% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.6557% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.7276% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.4601% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.5503% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.6735% (minimum 99%, Baseline (adaptation disabled)); colon: 71.9298% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.6117% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.5942% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.3529% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.6557% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.6557% (minimum 99%, Baseline (adaptation disabled)); kidney: 52.9032% (minimum 99%, Baseline (adaptation disabled)); liver: 72.9970% (minimum 99%, Baseline (adaptation disabled)); lung: 68.1440% (minimum 99%, Baseline (adaptation disabled)); lymph node: 79.0997% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.1881% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.5954% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 11.3364% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.7201% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.8462% (minimum 97%, Baseline (adaptation disabled)); retina: 66.8478% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.7201% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 67.9558% (minimum 99%, Baseline (adaptation disabled)); skin: 65.6000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.8462% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.7754% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.0952% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.1303% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.8478% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.6166% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.2929% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.1560% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.0794% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,21.9,192.4,26,"parathyroid gland: 192.4 nTPM (protected, limit 2); thymus: 26 nTPM (manageable, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); tongue: 17.7 nTPM (protected, limit 2); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 2); skin: 12.9 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 2); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); rectum: 6.6 nTPM (protected, limit 2); small intestine: 6.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144445,KANSL1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.463834,-0.856636,-0.460968
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 68.7151% (minimum 95%, Uncertain); adrenal gland: 75.4601% (minimum 99%, Missing); amygdala: 81.7276% (minimum 99%, Missing); basal ganglia: 80.6557% (minimum 99%, Missing); bone marrow: 81.7276% (minimum 99%, Missing); cerebellum: 75.4601% (minimum 99%, Missing); cerebral cortex: 82.5503% (minimum 99%, Missing); choroid plexus: 83.6735% (minimum 99%, Missing); colon: 71.9298% (minimum 97%, Missing); duodenum: 79.6117% (minimum 99%, Missing); esophagus: 78.5942% (minimum 97%, Missing); heart muscle: 72.3529% (minimum 99%, Missing); hippocampal formation: 80.6557% (minimum 99%, Missing); hypothalamus: 80.6557% (minimum 99%, Missing); kidney: 52.9032% (minimum 99%, Missing); liver: 72.9970% (minimum 99%, Missing); lung: 68.1440% (minimum 99%, Missing); lymph node: 79.0997% (minimum 97%, Missing); midbrain: 81.1881% (minimum 99%, Missing); pancreas: 62.5954% (minimum 99%, Missing); parathyroid gland: 11.3364% (minimum 97%, Missing); pituitary gland: 71.7201% (minimum 99%, Missing); rectum: 78.8462% (minimum 97%, Missing); retina: 66.8478% (minimum 99%, Missing); salivary gland: 71.7201% (minimum 97%, Missing); skeletal muscle: 67.9558% (minimum 99%, Missing); skin: 65.6000% (minimum 95%, Missing); small intestine: 78.8462% (minimum 99%, Missing); smooth muscle: 65.7754% (minimum 99%, Missing); spinal cord: 78.0952% (minimum 99%, Missing); spleen: 80.1303% (minimum 95%, Uncertain); stomach: 66.8478% (minimum 97%, Missing); thymus: 48.6166% (minimum 95%, Missing); thyroid gland: 56.2929% (minimum 95%, Missing); tongue: 58.1560% (minimum 97%, Missing); urinary bladder: 65.0794% (minimum 97%, Missing)",0,3,partial,21.9,192.4,26,"parathyroid gland: 192.4 nTPM (protected, limit 2); thymus: 26 nTPM (manageable, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); tongue: 17.7 nTPM (protected, limit 2); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 2); skin: 12.9 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 2); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); rectum: 6.6 nTPM (protected, limit 2); small intestine: 6.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144445,KANSL1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.463834,-0.856636,-0.460968
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.1,0.8,1.1,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000144488,ESPNL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 84.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.4545% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.3043% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 33.8710% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.4545% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 72.4138% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.5000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.4545% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.7778% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.4545% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 56.7568% (minimum 99%, Baseline (adaptation disabled)); lung: 91.3043% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.7692% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.4545% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.5000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 51.2195% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 91.3043% (minimum 99%, Baseline (adaptation disabled)); skin: 91.3043% (minimum 95%, Baseline (adaptation disabled)); small intestine: 38.1818% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.4545% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.6250% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.3043% (minimum 97%, Baseline (adaptation disabled)); thymus: 87.5000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 77.7778% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.1,0.8,1.1,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000144488,ESPNL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.29375,-0.245862,-0.65129
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 84.0000% (minimum 95%, Missing); adrenal gland: 87.5000% (minimum 99%, Missing); amygdala: 95.4545% (minimum 99%, Missing); basal ganglia: 91.3043% (minimum 99%, Missing); cerebellum: 33.8710% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); choroid plexus: 87.5000% (minimum 99%, Missing); colon: 72.4138% (minimum 97%, Missing); duodenum: 87.5000% (minimum 99%, Missing); esophagus: 95.4545% (minimum 97%, Missing); heart muscle: 77.7778% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); kidney: 87.5000% (minimum 99%, Missing); liver: 56.7568% (minimum 99%, Missing); lung: 91.3043% (minimum 99%, Missing); lymph node: 80.7692% (minimum 97%, Missing); midbrain: 95.4545% (minimum 99%, Missing); pancreas: 87.5000% (minimum 99%, Missing); pituitary gland: 51.2195% (minimum 99%, Missing); skeletal muscle: 91.3043% (minimum 99%, Missing); skin: 91.3043% (minimum 95%, Missing); small intestine: 38.1818% (minimum 99%, Missing); smooth muscle: 84.0000% (minimum 99%, Missing); spinal cord: 95.4545% (minimum 99%, Missing); spleen: 65.6250% (minimum 95%, Missing); stomach: 91.3043% (minimum 97%, Missing); thymus: 87.5000% (minimum 95%, Missing); thyroid gland: 70.0000% (minimum 95%, Missing); urinary bladder: 77.7778% (minimum 97%, Missing)",0,80,unavailable,4.1,0.8,1.1,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000144488,ESPNL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.29375,-0.245862,-0.65129
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,19.2,21.8,10,"parathyroid gland: 21.8 nTPM (protected, limit 2); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); rectum: 3.2 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000144619,CNTN4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.3681% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.3235% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.9275% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.9275% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.5955% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.5922% (minimum 99%, Baseline (adaptation disabled)); colon: 74.4318% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.5135% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.3665% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.5161% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.6204% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.5714% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.6082% (minimum 99%, Baseline (adaptation disabled)); liver: 82.3899% (minimum 99%, Baseline (adaptation disabled)); lung: 85.0649% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.9078% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.5714% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.7260% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 37.5358% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.3681% (minimum 97%, Baseline (adaptation disabled)); retina: 40.5573% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.2446% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.6204% (minimum 99%, Baseline (adaptation disabled)); skin: 94.9275% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.0588% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.2874% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.3235% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.5714% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.9157% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.6209% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.7100% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.0588% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.9157% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,19.2,21.8,10,"parathyroid gland: 21.8 nTPM (protected, limit 2); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); rectum: 3.2 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000144619,CNTN4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.3829,-0.594642,-0.584427
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.3681% (minimum 95%, Missing); adrenal gland: 96.3235% (minimum 99%, Missing); amygdala: 94.9275% (minimum 99%, Missing); basal ganglia: 94.9275% (minimum 99%, Missing); cerebellum: 73.5955% (minimum 99%, Missing); cerebral cortex: 63.5922% (minimum 99%, Missing); colon: 74.4318% (minimum 97%, Missing); duodenum: 88.5135% (minimum 99%, Missing); esophagus: 81.3665% (minimum 97%, Missing); heart muscle: 84.5161% (minimum 99%, Missing); hippocampal formation: 95.6204% (minimum 99%, Missing); hypothalamus: 93.5714% (minimum 99%, Missing); kidney: 76.6082% (minimum 99%, Missing); liver: 82.3899% (minimum 99%, Missing); lung: 85.0649% (minimum 99%, Missing); lymph node: 92.9078% (minimum 97%, Missing); midbrain: 93.5714% (minimum 99%, Missing); pancreas: 89.7260% (minimum 99%, Missing); parathyroid gland: 37.5358% (minimum 97%, Missing); pituitary gland: 87.3333% (minimum 99%, Missing); rectum: 80.3681% (minimum 97%, Missing); retina: 40.5573% (minimum 99%, Missing); salivary gland: 94.2446% (minimum 97%, Missing); skeletal muscle: 95.6204% (minimum 99%, Missing); skin: 94.9275% (minimum 95%, Missing); small intestine: 77.0588% (minimum 99%, Missing); smooth muscle: 75.2874% (minimum 99%, Missing); spinal cord: 96.3235% (minimum 99%, Missing); spleen: 93.5714% (minimum 95%, Missing); stomach: 78.9157% (minimum 97%, Missing); thymus: 85.6209% (minimum 95%, Missing); thyroid gland: 56.7100% (minimum 95%, Missing); tongue: 77.0588% (minimum 97%, Missing); urinary bladder: 78.9157% (minimum 97%, Missing)",0,80,unavailable,19.2,21.8,10,"parathyroid gland: 21.8 nTPM (protected, limit 2); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); rectum: 3.2 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000144619,CNTN4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.3829,-0.594642,-0.584427
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.3,0.2,0.1,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,ENSG00000144671,SLC22A14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.4138% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.4138% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.2609% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.6825% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.6230% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.4138% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.4138% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.7627% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2609% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.4138% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.4138% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.3,0.2,0.1,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,ENSG00000144671,SLC22A14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0412281,0.0126087,-0.0931746
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.4138% (minimum 99%, Missing); basal ganglia: 97.4138% (minimum 99%, Missing); bone marrow: 98.2609% (minimum 99%, Missing); cerebellum: 89.6825% (minimum 99%, Missing); cerebral cortex: 92.6230% (minimum 99%, Missing); hippocampal formation: 97.4138% (minimum 99%, Missing); hypothalamus: 97.4138% (minimum 99%, Missing); kidney: 95.7627% (minimum 99%, Missing); midbrain: 98.2609% (minimum 99%, Missing); pituitary gland: 97.4138% (minimum 99%, Missing); skeletal muscle: 97.4138% (minimum 99%, Missing)",0,80,unavailable,1.3,0.2,0.1,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,ENSG00000144671,SLC22A14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0412281,0.0126087,-0.0931746
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.4,1.4,1.5,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000144792,ZNF660,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.7442% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.7442% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.4878% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 58.9286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.1892% (minimum 99%, Baseline (adaptation disabled)); colon: 70.2128% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.0588% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.7442% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.7442% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.7442% (minimum 99%, Baseline (adaptation disabled)); liver: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 78.5714% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.5714% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.7442% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.4878% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.5000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.8947% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 42.8571% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 84.6154% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.1892% (minimum 99%, Baseline (adaptation disabled)); skin: 91.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.5714% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.7442% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.4878% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.4878% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.7500% (minimum 95%, Baseline (adaptation disabled)); tongue: 89.1892% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.4,1.4,1.5,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000144792,ZNF660,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.2625,-0.267872,-0.561429
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 82.5000% (minimum 99%, Missing); amygdala: 76.7442% (minimum 99%, Missing); basal ganglia: 76.7442% (minimum 99%, Missing); bone marrow: 80.4878% (minimum 99%, Missing); cerebellum: 58.9286% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 99%, Missing); choroid plexus: 89.1892% (minimum 99%, Missing); colon: 70.2128% (minimum 97%, Missing); duodenum: 97.0588% (minimum 99%, Missing); esophagus: 91.6667% (minimum 97%, Missing); heart muscle: 76.7442% (minimum 99%, Missing); hippocampal formation: 76.7442% (minimum 99%, Missing); hypothalamus: 73.3333% (minimum 99%, Missing); kidney: 76.7442% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 78.5714% (minimum 99%, Missing); lymph node: 78.5714% (minimum 97%, Missing); midbrain: 76.7442% (minimum 99%, Missing); pancreas: 80.4878% (minimum 99%, Missing); parathyroid gland: 82.5000% (minimum 97%, Missing); pituitary gland: 57.8947% (minimum 99%, Missing); rectum: 91.6667% (minimum 97%, Missing); retina: 42.8571% (minimum 99%, Missing); salivary gland: 84.6154% (minimum 97%, Missing); skeletal muscle: 89.1892% (minimum 99%, Missing); skin: 91.6667% (minimum 95%, Missing); small intestine: 78.5714% (minimum 99%, Missing); smooth muscle: 78.5714% (minimum 99%, Missing); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 76.7442% (minimum 95%, Missing); stomach: 80.4878% (minimum 97%, Missing); thymus: 80.4878% (minimum 95%, Missing); thyroid gland: 68.7500% (minimum 95%, Missing); tongue: 89.1892% (minimum 97%, Missing); urinary bladder: 73.3333% (minimum 97%, Missing)",0,80,unavailable,4.4,1.4,1.5,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000144792,ZNF660,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.2625,-0.267872,-0.561429
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,1,partial,3.1,2,0.5,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus,ENSG00000144821,MYH15,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 85.7143% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 30.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 33.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 50.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 33.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.0000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 30.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 33.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 66.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.7143% (minimum 97%, Baseline (adaptation disabled)); midbrain: 25.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 42.8571% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 16.2162% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.7143% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 54.5455% (minimum 95%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 26.0870% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.7143% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.7143% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.7143% (minimum 95%, Baseline (adaptation disabled)); tongue: 23.0769% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,3.1,2,0.5,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus,ENSG00000144821,MYH15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.404545,-0.739231,-0.827838
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 85.7143% (minimum 95%, Uncertain); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 30.0000% (minimum 99%, Missing); basal ganglia: 33.3333% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 99%, Missing); cerebellum: 50.0000% (minimum 99%, Missing); cerebral cortex: 33.3333% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Uncertain); duodenum: 60.0000% (minimum 99%, Uncertain); heart muscle: 60.0000% (minimum 99%, Missing); hippocampal formation: 30.0000% (minimum 99%, Missing); hypothalamus: 33.3333% (minimum 99%, Missing); lung: 66.6667% (minimum 99%, Missing); lymph node: 85.7143% (minimum 97%, Uncertain); midbrain: 25.0000% (minimum 99%, Missing); pituitary gland: 42.8571% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Uncertain); retina: 16.2162% (minimum 99%, Missing); salivary gland: 85.7143% (minimum 97%, Uncertain); skeletal muscle: 75.0000% (minimum 99%, Missing); skin: 54.5455% (minimum 95%, Missing); small intestine: 50.0000% (minimum 99%, Missing); spinal cord: 26.0870% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Uncertain); stomach: 85.7143% (minimum 97%, Uncertain); thymus: 85.7143% (minimum 95%, Missing); thyroid gland: 85.7143% (minimum 95%, Uncertain); tongue: 23.0769% (minimum 97%, Missing)",0,1,partial,3.1,2,0.5,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus,ENSG00000144821,MYH15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.404545,-0.739231,-0.827838
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,15.6,11.4,11.9,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); tongue: 11.4 nTPM (protected, limit 2); parathyroid gland: 11.4 nTPM (protected, limit 2); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 2); colon: 7.9 nTPM (protected, limit 2); esophagus: 7.7 nTPM (protected, limit 2); urinary bladder: 7.1 nTPM (protected, limit 2); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 2); salivary gland: 6.7 nTPM (protected, limit 2); pancreas: 6.2 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); pituitary gland: 6.1 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); lung: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144840,RABL3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.9735% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 35.2697% (minimum 99%, Baseline (adaptation disabled)); amygdala: 47.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 44.2708% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.5942% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 49.4186% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 46.4481% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.9630% (minimum 99%, Baseline (adaptation disabled)); colon: 51.8293% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.5942% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.4691% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.8387% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 49.7076% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 46.4481% (minimum 99%, Baseline (adaptation disabled)); kidney: 47.2222% (minimum 99%, Baseline (adaptation disabled)); liver: 47.4860% (minimum 99%, Baseline (adaptation disabled)); lung: 61.1511% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.4406% (minimum 97%, Baseline (adaptation disabled)); midbrain: 41.4634% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.8231% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 42.7136% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.2192% (minimum 99%, Baseline (adaptation disabled)); rectum: 50.5952% (minimum 97%, Baseline (adaptation disabled)); retina: 60.2837% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.9211% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 38.9908% (minimum 99%, Baseline (adaptation disabled)); skin: 58.2192% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.4406% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.6207% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 37.9464% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.1511% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.1948% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.8231% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 41.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 42.7136% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.4872% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,15.6,11.4,11.9,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); tongue: 11.4 nTPM (protected, limit 2); parathyroid gland: 11.4 nTPM (protected, limit 2); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 2); colon: 7.9 nTPM (protected, limit 2); esophagus: 7.7 nTPM (protected, limit 2); urinary bladder: 7.1 nTPM (protected, limit 2); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 2); salivary gland: 6.7 nTPM (protected, limit 2); pancreas: 6.2 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); pituitary gland: 6.1 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); lung: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144840,RABL3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.533333,-0.542864,-0.637303
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.9735% (minimum 95%, Missing); adrenal gland: 35.2697% (minimum 99%, Uncertain); amygdala: 47.2222% (minimum 99%, Missing); basal ganglia: 44.2708% (minimum 99%, Missing); bone marrow: 61.5942% (minimum 99%, Missing); cerebellum: 49.4186% (minimum 99%, Missing); cerebral cortex: 46.4481% (minimum 99%, Missing); choroid plexus: 62.9630% (minimum 99%, Missing); colon: 51.8293% (minimum 97%, Missing); duodenum: 61.5942% (minimum 99%, Missing); esophagus: 52.4691% (minimum 97%, Missing); heart muscle: 54.8387% (minimum 99%, Missing); hippocampal formation: 49.7076% (minimum 99%, Missing); hypothalamus: 46.4481% (minimum 99%, Missing); kidney: 47.2222% (minimum 99%, Missing); liver: 47.4860% (minimum 99%, Missing); lung: 61.1511% (minimum 99%, Missing); lymph node: 59.4406% (minimum 97%, Uncertain); midbrain: 41.4634% (minimum 99%, Missing); pancreas: 57.8231% (minimum 99%, Missing); parathyroid gland: 42.7136% (minimum 97%, Missing); pituitary gland: 58.2192% (minimum 99%, Missing); rectum: 50.5952% (minimum 97%, Missing); retina: 60.2837% (minimum 99%, Missing); salivary gland: 55.9211% (minimum 97%, Missing); skeletal muscle: 38.9908% (minimum 99%, Missing); skin: 58.2192% (minimum 95%, Missing); small intestine: 59.4406% (minimum 99%, Missing); smooth muscle: 58.6207% (minimum 99%, Missing); spinal cord: 37.9464% (minimum 99%, Missing); spleen: 61.1511% (minimum 95%, Uncertain); stomach: 55.1948% (minimum 97%, Missing); thymus: 57.8231% (minimum 95%, Missing); thyroid gland: 41.6667% (minimum 95%, Missing); tongue: 42.7136% (minimum 97%, Missing); urinary bladder: 54.4872% (minimum 97%, Missing)",0,4,partial,15.6,11.4,11.9,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); tongue: 11.4 nTPM (protected, limit 2); parathyroid gland: 11.4 nTPM (protected, limit 2); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 2); colon: 7.9 nTPM (protected, limit 2); esophagus: 7.7 nTPM (protected, limit 2); urinary bladder: 7.1 nTPM (protected, limit 2); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 2); salivary gland: 6.7 nTPM (protected, limit 2); pancreas: 6.2 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); pituitary gland: 6.1 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); lung: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000144840,RABL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.533333,-0.542864,-0.637303
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,3.8,1,0.7,"cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000144893,MED12L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 85.1064% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.1754% (minimum 99%, Baseline (adaptation disabled)); amygdala: 55.5556% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.8235% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 51.2821% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.5385% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 52.6316% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 59.7015% (minimum 99%, Baseline (adaptation disabled)); colon: 95.2381% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.2381% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.0233% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.5385% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.5385% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5610% (minimum 99%, Baseline (adaptation disabled)); lung: 95.2381% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 57.1429% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.5610% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.2381% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.4286% (minimum 99%, Baseline (adaptation disabled)); retina: 59.7015% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.0233% (minimum 99%, Baseline (adaptation disabled)); small intestine: 93.0233% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.0233% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.5385% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.9091% (minimum 95%, Baseline (adaptation disabled)); thymus: 90.9091% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.9091% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.0233% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,3.8,1,0.7,"bone marrow: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000144893,MED12L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0989362,-0.17,-0.477179
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.1754% (minimum 99%, Missing); amygdala: 55.5556% (minimum 99%, Missing); basal ganglia: 58.8235% (minimum 99%, Missing); bone marrow: 51.2821% (minimum 95%, Enhanced); cerebellum: 61.5385% (minimum 99%, Missing); cerebral cortex: 52.6316% (minimum 99%, Missing); choroid plexus: 59.7015% (minimum 99%, Missing); colon: 95.2381% (minimum 97%, Missing); duodenum: 83.3333% (minimum 99%, Missing); heart muscle: 93.0233% (minimum 95%, Enhanced); hippocampal formation: 61.5385% (minimum 99%, Missing); hypothalamus: 61.5385% (minimum 99%, Missing); lung: 95.2381% (minimum 99%, Missing); midbrain: 57.1429% (minimum 99%, Missing); pancreas: 97.5610% (minimum 99%, Missing); pituitary gland: 71.4286% (minimum 99%, Missing); retina: 59.7015% (minimum 99%, Missing); skeletal muscle: 93.0233% (minimum 95%, Enhanced); small intestine: 93.0233% (minimum 95%, Enhanced); smooth muscle: 93.0233% (minimum 99%, Missing); spinal cord: 61.5385% (minimum 99%, Missing); thymus: 90.9091% (minimum 95%, Missing)",0,1,partial,3.8,1,0.7,"cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil,ENSG00000144893,MED12L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0409091,-0.017619,-0.463684
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000144962,SPATA16,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000144962,SPATA16,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000144962,SPATA16,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.4,3.3,12.8,"skin: 12.8 nTPM (manageable, limit 5); esophagus: 3.3 nTPM (protected, limit 2); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,ENSG00000145040,UCN2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7273% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.5556% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.7273% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.4894% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.7273% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7273% (minimum 99%, Baseline (adaptation disabled)); colon: 95.5556% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.7273% (minimum 99%, Baseline (adaptation disabled)); esophagus: 56.5789% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.4783% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.7273% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.5833% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.4386% (minimum 99%, Baseline (adaptation disabled)); lung: 95.5556% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.7273% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.4783% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.8814% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.5556% (minimum 99%, Baseline (adaptation disabled)); skin: 25.1462% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.5556% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.5556% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.7273% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.7551% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 89.5833% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.4,3.3,12.8,"skin: 12.8 nTPM (manageable, limit 5); esophagus: 3.3 nTPM (protected, limit 2); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,ENSG00000145040,UCN2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.698538,-0.404211,-0.235614
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7273% (minimum 99%, Missing); basal ganglia: 95.5556% (minimum 99%, Missing); bone marrow: 97.7273% (minimum 99%, Missing); cerebellum: 91.4894% (minimum 99%, Missing); cerebral cortex: 97.7273% (minimum 99%, Missing); choroid plexus: 97.7273% (minimum 99%, Missing); colon: 95.5556% (minimum 97%, Missing); duodenum: 97.7273% (minimum 99%, Missing); esophagus: 56.5789% (minimum 97%, Missing); heart muscle: 93.4783% (minimum 99%, Missing); hippocampal formation: 97.7273% (minimum 99%, Missing); hypothalamus: 89.5833% (minimum 99%, Missing); kidney: 75.4386% (minimum 99%, Missing); lung: 95.5556% (minimum 99%, Missing); midbrain: 97.7273% (minimum 99%, Missing); pituitary gland: 93.4783% (minimum 99%, Missing); salivary gland: 72.8814% (minimum 97%, Missing); skeletal muscle: 95.5556% (minimum 99%, Missing); skin: 25.1462% (minimum 95%, Missing); small intestine: 95.5556% (minimum 99%, Missing); smooth muscle: 95.5556% (minimum 99%, Missing); spinal cord: 97.7273% (minimum 99%, Missing); spleen: 87.7551% (minimum 95%, Missing); urinary bladder: 89.5833% (minimum 97%, Missing)",0,80,unavailable,1.4,3.3,12.8,"skin: 12.8 nTPM (manageable, limit 5); esophagus: 3.3 nTPM (protected, limit 2); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,ENSG00000145040,UCN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.698538,-0.404211,-0.235614
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,27.8,18.9,28.9,"thymus: 28.9 nTPM (manageable, limit 5); bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 2); adipose tissue: 18.4 nTPM (manageable, limit 5); skin: 17.3 nTPM (manageable, limit 5); urinary bladder: 16.9 nTPM (protected, limit 2); parathyroid gland: 16.7 nTPM (protected, limit 6); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 2); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (manageable, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 2); salivary gland: 14.2 nTPM (protected, limit 6); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 2); lung: 13.8 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 2); duodenum: 11 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000145216,FIP1L1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.4490% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.8122% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.5577% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.3973% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.6697% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.7039% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.1671% (minimum 99%, Baseline (adaptation disabled)); colon: 68.7640% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.5577% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.5217% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.9977% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.1843% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.3448% (minimum 99%, Baseline (adaptation disabled)); liver: 70.1835% (minimum 99%, Baseline (adaptation disabled)); lung: 68.9189% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.8182% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.6341% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.9305% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.6934% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.5000% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.1514% (minimum 97%, Baseline (adaptation disabled)); retina: 65.2452% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.3036% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.1351% (minimum 99%, Baseline (adaptation disabled)); skin: 63.8831% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.6099% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.4009% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.1628% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.0745% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.5455% (minimum 97%, Baseline (adaptation disabled)); thymus: 51.4286% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 67.2527% (minimum 95%, Baseline (adaptation disabled)); tongue: 72.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.4211% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,27.8,18.9,28.9,"thymus: 28.9 nTPM (manageable, limit 5); bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 2); adipose tissue: 18.4 nTPM (manageable, limit 5); skin: 17.3 nTPM (manageable, limit 5); urinary bladder: 16.9 nTPM (protected, limit 2); parathyroid gland: 16.7 nTPM (protected, limit 2); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 2); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (manageable, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 2); salivary gland: 14.2 nTPM (protected, limit 2); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 2); lung: 13.8 nTPM (vital, limit 1); spleen: 13.7 nTPM (manageable, limit 5); stomach: 13.4 nTPM (protected, limit 2); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 2); amygdala: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000145216,FIP1L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.435714,-0.351818,-0.466027
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.4490% (minimum 95%, Missing); adrenal gland: 66.8122% (minimum 99%, Missing); amygdala: 73.5577% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 52.3973% (minimum 99%, Missing); cerebellum: 70.6697% (minimum 99%, Missing); cerebral cortex: 69.7039% (minimum 99%, Missing); choroid plexus: 81.1671% (minimum 99%, Missing); colon: 68.7640% (minimum 97%, Missing); duodenum: 73.5577% (minimum 99%, Missing); esophagus: 66.5217% (minimum 97%, Missing); heart muscle: 70.9977% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 75.1843% (minimum 99%, Missing); kidney: 70.3448% (minimum 99%, Missing); liver: 70.1835% (minimum 99%, Missing); lung: 68.9189% (minimum 99%, Missing); lymph node: 61.8182% (minimum 97%, Missing); midbrain: 74.6341% (minimum 99%, Missing); pancreas: 75.9305% (minimum 99%, Missing); parathyroid gland: 64.6934% (minimum 90%, Supported); pituitary gland: 76.5000% (minimum 99%, Missing); rectum: 68.1514% (minimum 97%, Missing); retina: 65.2452% (minimum 99%, Missing); salivary gland: 68.3036% (minimum 90%, Supported); skeletal muscle: 55.1351% (minimum 99%, Missing); skin: 63.8831% (minimum 95%, Missing); small intestine: 68.6099% (minimum 99%, Missing); smooth muscle: 67.4009% (minimum 99%, Missing); spinal cord: 71.1628% (minimum 99%, Missing); spleen: 69.0745% (minimum 80%, Supported); stomach: 69.5455% (minimum 97%, Missing); thymus: 51.4286% (minimum 95%, Missing); thyroid gland: 67.2527% (minimum 95%, Missing); tongue: 72.0000% (minimum 97%, Missing); urinary bladder: 64.4211% (minimum 97%, Missing)",0,7,partial,27.8,18.9,28.9,"thymus: 28.9 nTPM (manageable, limit 5); bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 2); adipose tissue: 18.4 nTPM (manageable, limit 5); skin: 17.3 nTPM (manageable, limit 5); urinary bladder: 16.9 nTPM (protected, limit 2); parathyroid gland: 16.7 nTPM (protected, limit 6); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 2); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (manageable, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 2); salivary gland: 14.2 nTPM (protected, limit 6); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 2); lung: 13.8 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 2); duodenum: 11 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000145216,FIP1L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.435714,-0.351818,-0.466027
True,compatible,,True,True,False,,0,1,partial,0,3.9,0,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000145309,CABS1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 96.3653% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,0,3.9,0,"salivary gland: 3.9 nTPM (protected, limit 2)",,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000145309,CABS1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,-0.00634669,0.01
True,compatible,,True,True,True,,0,1,partial,0,3.9,0,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000145309,CABS1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.5,4.3,5.9,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 2); stomach: 4.3 nTPM (protected, limit 2); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000145331,TRMT10A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.0730% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.7273% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.3559% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.6885% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.3559% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.4865% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.5906% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.4286% (minimum 99%, Baseline (adaptation disabled)); colon: 73.2824% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.5652% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.2824% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.3559% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.6723% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.6723% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 50.2618% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.0647% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.4194% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.7451% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 72.7273% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.6723% (minimum 99%, Baseline (adaptation disabled)); rectum: 73.2824% (minimum 97%, Baseline (adaptation disabled)); retina: 78.0488% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.6418% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.6418% (minimum 99%, Baseline (adaptation disabled)); skin: 72.7273% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.5714% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.6885% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.6418% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.8462% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.0647% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.5652% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.9355% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.6885% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.4194% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.5,4.3,5.9,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 2); stomach: 4.3 nTPM (protected, limit 2); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000145331,TRMT10A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.330645,-0.279353,-0.487382
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.0730% (minimum 95%, Missing); adrenal gland: 72.7273% (minimum 99%, Missing); amygdala: 81.3559% (minimum 99%, Missing); basal ganglia: 78.6885% (minimum 99%, Missing); bone marrow: 81.3559% (minimum 99%, Missing); cerebellum: 86.4865% (minimum 99%, Missing); cerebral cortex: 75.5906% (minimum 99%, Missing); choroid plexus: 91.4286% (minimum 99%, Missing); colon: 73.2824% (minimum 97%, Missing); duodenum: 69.5652% (minimum 99%, Missing); esophagus: 73.2824% (minimum 97%, Missing); heart muscle: 81.3559% (minimum 99%, Missing); hippocampal formation: 80.6723% (minimum 99%, Missing); hypothalamus: 80.6723% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 50.2618% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 69.0647% (minimum 97%, Missing); midbrain: 77.4194% (minimum 99%, Missing); pancreas: 62.7451% (minimum 99%, Missing); parathyroid gland: 72.7273% (minimum 97%, Missing); pituitary gland: 80.6723% (minimum 99%, Missing); rectum: 73.2824% (minimum 97%, Missing); retina: 78.0488% (minimum 99%, Missing); salivary gland: 71.6418% (minimum 97%, Missing); skeletal muscle: 71.6418% (minimum 99%, Missing); skin: 72.7273% (minimum 95%, Missing); small intestine: 68.5714% (minimum 99%, Missing); smooth muscle: 78.6885% (minimum 99%, Missing); spinal cord: 71.6418% (minimum 99%, Missing); spleen: 73.8462% (minimum 95%, Missing); stomach: 69.0647% (minimum 97%, Missing); thymus: 69.5652% (minimum 95%, Missing); thyroid gland: 61.9355% (minimum 95%, Missing); tongue: 78.6885% (minimum 97%, Missing); urinary bladder: 77.4194% (minimum 97%, Missing)",0,80,unavailable,9.5,4.3,5.9,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 2); stomach: 4.3 nTPM (protected, limit 2); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.6 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); cerebral cortex: 3.1 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000145331,TRMT10A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.330645,-0.279353,-0.487382
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,2.2,2.3,2,"stomach: 2.3 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000145375,AFG2A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.9167% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.3953% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 71.4286% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.3953% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.3953% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.3659% (minimum 99%, Baseline (adaptation disabled)); colon: 77.7778% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.7778% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.3953% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.5000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.3659% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.0870% (minimum 99%, Baseline (adaptation disabled)); liver: 76.0870% (minimum 99%, Baseline (adaptation disabled)); lung: 79.5455% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.4681% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.3659% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.3953% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.4681% (minimum 97%, Baseline (adaptation disabled)); retina: 61.4035% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.0870% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 72.9167% (minimum 99%, Baseline (adaptation disabled)); skin: 74.4681% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 74.4681% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.4681% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.3448% (minimum 97%, Baseline (adaptation disabled)); thymus: 63.6364% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 74.4681% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.7778% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,2.2,2.3,2,"stomach: 2.3 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000145375,AFG2A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.313636,-0.366552,-0.375965
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.9167% (minimum 90%, Approved); adrenal gland: 81.3953% (minimum 99%, Missing); amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 71.4286% (minimum 99%, Missing); cerebellum: 81.3953% (minimum 99%, Missing); cerebral cortex: 81.3953% (minimum 99%, Missing); choroid plexus: 85.3659% (minimum 99%, Missing); colon: 77.7778% (minimum 97%, Missing); duodenum: 83.3333% (minimum 99%, Missing); esophagus: 77.7778% (minimum 97%, Missing); heart muscle: 81.3953% (minimum 99%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing); hypothalamus: 85.3659% (minimum 99%, Missing); kidney: 76.0870% (minimum 99%, Missing); liver: 76.0870% (minimum 99%, Missing); lung: 79.5455% (minimum 99%, Missing); lymph node: 74.4681% (minimum 97%, Missing); midbrain: 85.3659% (minimum 99%, Missing); pancreas: 81.3953% (minimum 99%, Missing); parathyroid gland: 70.0000% (minimum 97%, Missing); pituitary gland: 83.3333% (minimum 99%, Missing); rectum: 74.4681% (minimum 97%, Missing); retina: 61.4035% (minimum 99%, Missing); salivary gland: 76.0870% (minimum 97%, Missing); skeletal muscle: 72.9167% (minimum 98%, Approved); skin: 74.4681% (minimum 95%, Missing); small intestine: 83.3333% (minimum 99%, Missing); smooth muscle: 74.4681% (minimum 98%, Approved); spinal cord: 83.3333% (minimum 99%, Missing); spleen: 74.4681% (minimum 95%, Missing); stomach: 60.3448% (minimum 97%, Missing); thymus: 63.6364% (minimum 95%, Missing); thyroid gland: 70.0000% (minimum 95%, Missing); tongue: 74.4681% (minimum 97%, Missing); urinary bladder: 77.7778% (minimum 97%, Missing)",0,0,routine_complete,2.2,2.3,2,"stomach: 2.3 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000145375,AFG2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.313636,-0.366552,-0.375965
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,11,0.4,4.3,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000145491,ROPN1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Jamin 2021;Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.9288% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.7421% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6491% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.6154% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2171% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5562% (minimum 99%, Baseline (adaptation disabled)); lung: 98.3709% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,11,0.4,4.3,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000145491,ROPN1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Jamin 2021;Chang 2019;Wang 2016;Gong 2021,0.0364907,0.0287277,-0.0238462
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.9288% (minimum 99%, Missing); basal ganglia: 98.7421% (minimum 99%, Missing); choroid plexus: 96.6154% (minimum 99%, Missing); hippocampal formation: 98.2171% (minimum 99%, Missing); hypothalamus: 98.5562% (minimum 99%, Missing)",0,4,partial,11,0.4,4.3,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000145491,ROPN1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Jamin 2021;Chang 2019;Wang 2016;Gong 2021,0.0493635,0.0290455,-0.0238462
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,42,30.5,18.1,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 2); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 2); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); smooth muscle: 8.5 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); rectum: 7.7 nTPM (protected, limit 2); colon: 7.6 nTPM (protected, limit 2); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.4 nTPM (vital, limit 1); salivary gland: 7.4 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000145743,FBXL17,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.1538% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.5780% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.8919% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.9189% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.4737% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 37.7778% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.6917% (minimum 99%, Baseline (adaptation disabled)); colon: 57.3034% (minimum 97%, Baseline (adaptation disabled)); duodenum: 56.0440% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.9683% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 34.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.4444% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.8919% (minimum 99%, Baseline (adaptation disabled)); kidney: 44.7368% (minimum 99%, Baseline (adaptation disabled)); liver: 49.0385% (minimum 99%, Baseline (adaptation disabled)); lung: 60.7143% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.4458% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.4444% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.9545% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 34.9315% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.7273% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.9832% (minimum 97%, Baseline (adaptation disabled)); retina: 35.0515% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.9545% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 19.5402% (minimum 99%, Baseline (adaptation disabled)); skin: 60.7143% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.7377% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 54.5455% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.5780% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.4348% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.9832% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.9545% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 36.0424% (minimum 95%, Baseline (adaptation disabled)); tongue: 25.0614% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.1951% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,42,30.5,18.1,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 2); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 2); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); smooth muscle: 8.5 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); rectum: 7.7 nTPM (protected, limit 2); colon: 7.6 nTPM (protected, limit 2); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.4 nTPM (vital, limit 1); salivary gland: 7.4 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000145743,FBXL17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.589576,-0.719386,-0.794598
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.1538% (minimum 95%, Missing); adrenal gland: 50.0000% (minimum 99%, Missing); amygdala: 93.5780% (minimum 99%, Missing); basal ganglia: 91.8919% (minimum 99%, Missing); bone marrow: 68.9189% (minimum 99%, Missing); cerebellum: 89.4737% (minimum 99%, Missing); cerebral cortex: 37.7778% (minimum 99%, Missing); choroid plexus: 76.6917% (minimum 99%, Missing); colon: 57.3034% (minimum 97%, Missing); duodenum: 56.0440% (minimum 99%, Missing); esophagus: 53.9683% (minimum 97%, Missing); heart muscle: 34.0000% (minimum 99%, Missing); hippocampal formation: 94.4444% (minimum 99%, Missing); hypothalamus: 91.8919% (minimum 99%, Missing); kidney: 44.7368% (minimum 99%, Missing); liver: 49.0385% (minimum 99%, Uncertain); lung: 60.7143% (minimum 99%, Missing); lymph node: 61.4458% (minimum 97%, Uncertain); midbrain: 94.4444% (minimum 99%, Missing); pancreas: 57.9545% (minimum 99%, Missing); parathyroid gland: 34.9315% (minimum 97%, Uncertain); pituitary gland: 92.7273% (minimum 99%, Missing); rectum: 56.9832% (minimum 97%, Missing); retina: 35.0515% (minimum 99%, Missing); salivary gland: 57.9545% (minimum 97%, Missing); skeletal muscle: 19.5402% (minimum 99%, Missing); skin: 60.7143% (minimum 95%, Missing); small intestine: 55.7377% (minimum 99%, Missing); smooth muscle: 54.5455% (minimum 99%, Missing); spinal cord: 93.5780% (minimum 99%, Missing); spleen: 55.4348% (minimum 95%, Missing); stomach: 56.9832% (minimum 97%, Uncertain); thymus: 57.9545% (minimum 95%, Missing); thyroid gland: 36.0424% (minimum 95%, Uncertain); tongue: 25.0614% (minimum 97%, Missing); urinary bladder: 62.1951% (minimum 97%, Missing)",0,6,partial,42,30.5,18.1,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 2); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 2); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); smooth muscle: 8.5 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); rectum: 7.7 nTPM (protected, limit 2); colon: 7.6 nTPM (protected, limit 2); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.4 nTPM (vital, limit 1); salivary gland: 7.4 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000145743,FBXL17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.589576,-0.719386,-0.794598
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,4,partial,0.3,0.2,1,,caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen,ENSG00000145757,SPATA9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8593% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.8593% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,0.3,0.2,1,,caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen,ENSG00000145757,SPATA9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.012963,0.0223664,-0.00140684
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"pancreas: 98.8593% (minimum 99%, Missing)",0,4,partial,0.3,0.2,1,,caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen,ENSG00000145757,SPATA9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0223664,-0.00140684
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,15.8,53.9,21.8,"lymph node: 53.9 nTPM (protected, limit 2); thymus: 21.8 nTPM (manageable, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 2); adipose tissue: 14.3 nTPM (manageable, limit 10); spleen: 7.8 nTPM (manageable, limit 5); urinary bladder: 4.7 nTPM (protected, limit 4); kidney: 3.3 nTPM (vital, limit 2); choroid plexus: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000145850,TIMD4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.7323% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 89.8588% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.6971% (minimum 99%, Baseline (adaptation disabled)); liver: 89.8588% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8701% (minimum 99%, Baseline (adaptation disabled)); lymph node: 72.2022% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.8003% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.7226% (minimum 95%, Baseline (adaptation disabled)); thymus: 86.5266% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.7519% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,15.8,53.9,21.8,"lymph node: 53.9 nTPM (protected, limit 2); thymus: 21.8 nTPM (manageable, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); urinary bladder: 4.7 nTPM (protected, limit 2); kidney: 3.3 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000145850,TIMD4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0847342,-0.247978,-0.0914121
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 89.8588% (minimum 99%, Missing); kidney: 97.6971% (minimum 98%, Approved); liver: 89.8588% (minimum 98%, Approved); lymph node: 72.2022% (minimum 97%, Missing); spleen: 94.7226% (minimum 95%, Missing); thymus: 86.5266% (minimum 95%, Missing)",0,4,partial,15.8,53.9,21.8,"lymph node: 53.9 nTPM (protected, limit 2); thymus: 21.8 nTPM (manageable, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 2); adipose tissue: 14.3 nTPM (manageable, limit 10); spleen: 7.8 nTPM (manageable, limit 5); urinary bladder: 4.7 nTPM (protected, limit 4); kidney: 3.3 nTPM (vital, limit 2); choroid plexus: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000145850,TIMD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0847342,-0.247978,-0.0914121
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,18,17.9,19.7,"thymus: 19.7 nTPM (manageable, limit 5); skeletal muscle: 18 nTPM (vital, limit 2); parathyroid gland: 17.9 nTPM (protected, limit 2); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 2); lymph node: 14.2 nTPM (protected, limit 4); lung: 14.1 nTPM (vital, limit 1); spleen: 14 nTPM (manageable, limit 10); urinary bladder: 13.3 nTPM (protected, limit 2); rectum: 12.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (manageable, limit 10); colon: 12.1 nTPM (protected, limit 2); stomach: 12.1 nTPM (protected, limit 2); thyroid gland: 11.9 nTPM (manageable, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); small intestine: 11.3 nTPM (vital, limit 1); salivary gland: 11.2 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 2); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 2); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000145868,FBXO38,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.2075% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 55.9524% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.4641% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.5814% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.2437% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.1753% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.7759% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.3836% (minimum 99%, Baseline (adaptation disabled)); colon: 53.8168% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 58.0247% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 45.6311% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.9770% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.8879% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.0075% (minimum 99%, Baseline (adaptation disabled)); liver: 44.6203% (minimum 99%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.8233% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.6789% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.5150% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 44.0625% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.7500% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.8090% (minimum 97%, Baseline (adaptation disabled)); retina: 57.0850% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.7312% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 43.9252% (minimum 99%, Baseline (adaptation disabled)); skin: 54.4402% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.5118% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 54.4402% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 60.2564% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.1779% (minimum 95%, Baseline (adaptation disabled)); stomach: 53.8168% (minimum 97%, Baseline (adaptation disabled)); thymus: 41.7160% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.2308% (minimum 95%, Baseline (adaptation disabled)); tongue: 46.5347% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.4599% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,18,17.9,19.7,"thymus: 19.7 nTPM (manageable, limit 5); skeletal muscle: 18 nTPM (vital, limit 1); parathyroid gland: 17.9 nTPM (protected, limit 2); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 2); lymph node: 14.2 nTPM (protected, limit 2); lung: 14.1 nTPM (vital, limit 1); spleen: 14 nTPM (manageable, limit 5); urinary bladder: 13.3 nTPM (protected, limit 2); rectum: 12.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.1 nTPM (protected, limit 2); stomach: 12.1 nTPM (protected, limit 2); thyroid gland: 11.9 nTPM (manageable, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); small intestine: 11.3 nTPM (vital, limit 1); salivary gland: 11.2 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 2); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 1); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000145868,FBXO38,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.53284,-0.529375,-0.550748
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.2075% (minimum 90%, Approved); adrenal gland: 55.9524% (minimum 99%, Missing); amygdala: 67.4641% (minimum 99%, Missing); basal ganglia: 65.5814% (minimum 99%, Missing); bone marrow: 59.2437% (minimum 98%, Approved); cerebellum: 56.1753% (minimum 99%, Missing); cerebral cortex: 60.7759% (minimum 99%, Missing); choroid plexus: 64.3836% (minimum 99%, Missing); colon: 53.8168% (minimum 97%, Missing); duodenum: 60.0000% (minimum 99%, Missing); esophagus: 58.0247% (minimum 97%, Missing); heart muscle: 45.6311% (minimum 99%, Missing); hippocampal formation: 64.9770% (minimum 99%, Missing); hypothalamus: 65.8879% (minimum 99%, Missing); kidney: 53.0075% (minimum 99%, Missing); liver: 44.6203% (minimum 99%, Missing); lung: 50.0000% (minimum 99%, Missing); lymph node: 49.8233% (minimum 95%, Approved); midbrain: 64.6789% (minimum 99%, Missing); pancreas: 60.5150% (minimum 99%, Missing); parathyroid gland: 44.0625% (minimum 97%, Missing); pituitary gland: 58.7500% (minimum 99%, Missing); rectum: 52.8090% (minimum 97%, Missing); retina: 57.0850% (minimum 99%, Missing); salivary gland: 55.7312% (minimum 97%, Missing); skeletal muscle: 43.9252% (minimum 98%, Approved); skin: 54.4402% (minimum 95%, Missing); small intestine: 55.5118% (minimum 99%, Missing); smooth muscle: 54.4402% (minimum 99%, Missing); spinal cord: 60.2564% (minimum 99%, Missing); spleen: 50.1779% (minimum 90%, Approved); stomach: 53.8168% (minimum 97%, Missing); thymus: 41.7160% (minimum 95%, Missing); thyroid gland: 54.2308% (minimum 95%, Missing); tongue: 46.5347% (minimum 97%, Missing); urinary bladder: 51.4599% (minimum 97%, Missing)",0,3,partial,18,17.9,19.7,"thymus: 19.7 nTPM (manageable, limit 5); skeletal muscle: 18 nTPM (vital, limit 2); parathyroid gland: 17.9 nTPM (protected, limit 2); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 2); lymph node: 14.2 nTPM (protected, limit 4); lung: 14.1 nTPM (vital, limit 1); spleen: 14 nTPM (manageable, limit 10); urinary bladder: 13.3 nTPM (protected, limit 2); rectum: 12.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (manageable, limit 10); colon: 12.1 nTPM (protected, limit 2); stomach: 12.1 nTPM (protected, limit 2); thyroid gland: 11.9 nTPM (manageable, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); small intestine: 11.3 nTPM (vital, limit 1); salivary gland: 11.2 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 2); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 2); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000145868,FBXO38,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.53284,-0.529375,-0.543797
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,0,0,"pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000145975,FAM217A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 97.9730% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.6250% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.5,0,0,"pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000145975,FAM217A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.08375
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 97.9730% (minimum 99%, Missing); pancreas: 90.6250% (minimum 99%, Missing)",0,80,unavailable,1.5,0,0,"pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000145975,FAM217A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.08375
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,30.5,16.7,16.4,"heart muscle: 30.5 nTPM (vital, limit 2); bone marrow: 26.1 nTPM (vital, limit 2); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 15.9 nTPM (protected, limit 4); skeletal muscle: 15.7 nTPM (vital, limit 2); colon: 14.7 nTPM (protected, limit 4); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 2); lymph node: 13.6 nTPM (protected, limit 4); hippocampal formation: 13.6 nTPM (vital, limit 1); skin: 13.3 nTPM (manageable, limit 10); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); spleen: 12 nTPM (manageable, limit 10); parathyroid gland: 12 nTPM (protected, limit 2); salivary gland: 11.8 nTPM (protected, limit 4); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 2); lung: 10.6 nTPM (vital, limit 2); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 2); urinary bladder: 9.6 nTPM (protected, limit 4); stomach: 9.5 nTPM (protected, limit 4); choroid plexus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000145979,TBC1D7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.0702% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.5806% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.8765% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.5873% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 42.6374% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.4518% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.1873% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.5958% (minimum 99%, Baseline (adaptation disabled)); colon: 56.8915% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.9104% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.7396% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 38.8778% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.7879% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.4361% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.6216% (minimum 99%, Baseline (adaptation disabled)); liver: 53.1507% (minimum 99%, Baseline (adaptation disabled)); lung: 64.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.7879% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.3924% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.2116% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.7834% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 65.1007% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.9575% (minimum 97%, Baseline (adaptation disabled)); retina: 63.6066% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.1795% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.2707% (minimum 99%, Baseline (adaptation disabled)); skin: 59.3272% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.8829% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 60.0619% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.7834% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.1280% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.1899% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.3235% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.2583% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.8966% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,30.5,16.7,16.4,"heart muscle: 30.5 nTPM (vital, limit 1); bone marrow: 26.1 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 2); thymus: 16.4 nTPM (manageable, limit 5); rectum: 15.9 nTPM (protected, limit 2); skeletal muscle: 15.7 nTPM (vital, limit 1); colon: 14.7 nTPM (protected, limit 2); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 2); hippocampal formation: 13.6 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 2); skin: 13.3 nTPM (manageable, limit 5); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); parathyroid gland: 12 nTPM (protected, limit 2); spleen: 12 nTPM (manageable, limit 5); salivary gland: 11.8 nTPM (protected, limit 2); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); urinary bladder: 9.6 nTPM (protected, limit 2); stomach: 9.5 nTPM (protected, limit 2); choroid plexus: 9.3 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); thyroid gland: 7.8 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000145979,TBC1D7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.408101,-0.432604,-0.601222
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.0702% (minimum 90%, Approved); adrenal gland: 62.5806% (minimum 99%, Missing); amygdala: 59.8765% (minimum 99%, Missing); basal ganglia: 61.5873% (minimum 99%, Missing); bone marrow: 42.6374% (minimum 98%, Approved); cerebellum: 64.4518% (minimum 98%, Approved); cerebral cortex: 51.1873% (minimum 99%, Missing); choroid plexus: 67.5958% (minimum 99%, Missing); colon: 56.8915% (minimum 95%, Approved); duodenum: 57.9104% (minimum 99%, Missing); esophagus: 53.7396% (minimum 95%, Approved); heart muscle: 38.8778% (minimum 98%, Approved); hippocampal formation: 58.7879% (minimum 99%, Missing); hypothalamus: 60.4361% (minimum 99%, Missing); kidney: 48.6216% (minimum 99%, Missing); liver: 53.1507% (minimum 99%, Missing); lung: 64.6667% (minimum 98%, Approved); lymph node: 58.7879% (minimum 95%, Approved); midbrain: 61.3924% (minimum 99%, Missing); pancreas: 66.2116% (minimum 99%, Missing); parathyroid gland: 61.7834% (minimum 97%, Missing); pituitary gland: 65.1007% (minimum 99%, Missing); rectum: 54.9575% (minimum 95%, Approved); retina: 63.6066% (minimum 99%, Missing); salivary gland: 62.1795% (minimum 95%, Approved); skeletal muscle: 55.2707% (minimum 98%, Approved); skin: 59.3272% (minimum 90%, Approved); small intestine: 64.8829% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 98%, Approved); spinal cord: 60.0619% (minimum 99%, Missing); spleen: 61.7834% (minimum 90%, Approved); stomach: 67.1280% (minimum 95%, Approved); thymus: 54.1899% (minimum 95%, Missing); thyroid gland: 71.3235% (minimum 90%, Approved); tongue: 58.2583% (minimum 97%, Missing); urinary bladder: 66.8966% (minimum 95%, Approved)",0,3,partial,30.5,16.7,16.4,"heart muscle: 30.5 nTPM (vital, limit 2); bone marrow: 26.1 nTPM (vital, limit 2); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 15.9 nTPM (protected, limit 4); skeletal muscle: 15.7 nTPM (vital, limit 2); colon: 14.7 nTPM (protected, limit 4); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 2); lymph node: 13.6 nTPM (protected, limit 4); hippocampal formation: 13.6 nTPM (vital, limit 1); skin: 13.3 nTPM (manageable, limit 10); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); spleen: 12 nTPM (manageable, limit 10); parathyroid gland: 12 nTPM (protected, limit 2); salivary gland: 11.8 nTPM (protected, limit 4); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 2); lung: 10.6 nTPM (vital, limit 2); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 2); urinary bladder: 9.6 nTPM (protected, limit 4); stomach: 9.5 nTPM (protected, limit 4); choroid plexus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000145979,TBC1D7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.408101,-0.412604,-0.591222
True,compatible,family_exclusion,True,True,False,,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000146047,H2BC1,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;family_exclusion,True,True,True,"kidney: 98.4127% (minimum 99%, Baseline (adaptation disabled)); liver: 98.4127% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000146047,H2BC1,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,0.05,0.03,-0.00587302
True,compatible,family_exclusion,True,True,True,,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000146047,H2BC1,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.6,0.2,0.5,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000146221,TCTE1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.4025% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.8239% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.0100% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.3478% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.5361% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.7377% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.1642% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.2500% (minimum 99%, Baseline (adaptation disabled)); lung: 95.4248% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.4248% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.3165% (minimum 99%, Baseline (adaptation disabled)); retina: 96.6887% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.0526% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,7.6,0.2,0.5,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000146221,TCTE1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.033165,0.0231973,-0.196522
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.4025% (minimum 99%, Missing); basal ganglia: 91.8239% (minimum 99%, Missing); bone marrow: 97.0100% (minimum 99%, Missing); cerebellum: 79.3478% (minimum 99%, Missing); cerebral cortex: 91.5361% (minimum 99%, Missing); choroid plexus: 95.7377% (minimum 99%, Missing); hippocampal formation: 87.1642% (minimum 99%, Missing); hypothalamus: 91.2500% (minimum 99%, Missing); lung: 95.4248% (minimum 99%, Missing); midbrain: 95.4248% (minimum 99%, Missing); pituitary gland: 98.3165% (minimum 99%, Missing); retina: 96.6887% (minimum 99%, Missing); spinal cord: 96.0526% (minimum 99%, Missing)",0,80,unavailable,7.6,0.2,0.5,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000146221,TCTE1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.033165,0.0231973,-0.196522
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.4,3.5,3.2,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); stomach: 3.3 nTPM (protected, limit 2); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000146243,IRAK1BP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 74.1379% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.1818% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.4918% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 44.7917% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.1379% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.8814% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.3548% (minimum 99%, Baseline (adaptation disabled)); colon: 72.8814% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.6296% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.1818% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.8814% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.7857% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.1379% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.5634% (minimum 99%, Baseline (adaptation disabled)); liver: 82.6923% (minimum 99%, Baseline (adaptation disabled)); lung: 67.1875% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.4918% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.6296% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.1081% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.1282% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.5789% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.7857% (minimum 97%, Baseline (adaptation disabled)); retina: 44.3299% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.3188% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 79.6296% (minimum 99%, Baseline (adaptation disabled)); skin: 66.1538% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.4386% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.2540% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.6296% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.3548% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.5789% (minimum 97%, Baseline (adaptation disabled)); thymus: 59.7222% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.1321% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.4386% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.4,3.5,3.2,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); stomach: 3.3 nTPM (protected, limit 2); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000146243,IRAK1BP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.376667,-0.418718,-0.546701
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 74.1379% (minimum 95%, Missing); adrenal gland: 71.6667% (minimum 99%, Missing); amygdala: 78.1818% (minimum 99%, Missing); basal ganglia: 70.4918% (minimum 99%, Missing); bone marrow: 44.7917% (minimum 99%, Missing); cerebellum: 74.1379% (minimum 99%, Missing); cerebral cortex: 72.8814% (minimum 99%, Missing); choroid plexus: 69.3548% (minimum 99%, Missing); colon: 72.8814% (minimum 97%, Missing); duodenum: 79.6296% (minimum 99%, Missing); esophagus: 78.1818% (minimum 97%, Missing); heart muscle: 72.8814% (minimum 99%, Missing); hippocampal formation: 76.7857% (minimum 99%, Missing); hypothalamus: 74.1379% (minimum 99%, Missing); kidney: 60.5634% (minimum 99%, Missing); liver: 82.6923% (minimum 99%, Missing); lung: 67.1875% (minimum 99%, Missing); lymph node: 70.4918% (minimum 97%, Missing); midbrain: 79.6296% (minimum 99%, Missing); pancreas: 58.1081% (minimum 99%, Missing); parathyroid gland: 55.1282% (minimum 97%, Missing); pituitary gland: 56.5789% (minimum 99%, Missing); rectum: 76.7857% (minimum 97%, Missing); retina: 44.3299% (minimum 99%, Missing); salivary gland: 62.3188% (minimum 97%, Missing); skeletal muscle: 79.6296% (minimum 99%, Missing); skin: 66.1538% (minimum 95%, Missing); small intestine: 75.4386% (minimum 99%, Missing); smooth muscle: 68.2540% (minimum 99%, Missing); spinal cord: 79.6296% (minimum 99%, Missing); spleen: 69.3548% (minimum 95%, Missing); stomach: 56.5789% (minimum 97%, Missing); thymus: 59.7222% (minimum 95%, Missing); thyroid gland: 57.3333% (minimum 95%, Missing); tongue: 81.1321% (minimum 97%, Missing); urinary bladder: 75.4386% (minimum 97%, Missing)",0,80,unavailable,5.4,3.5,3.2,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); stomach: 3.3 nTPM (protected, limit 2); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000146243,IRAK1BP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.376667,-0.418718,-0.546701
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7,3.4,5.1,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); lymph node: 3.4 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000146263,MMS22L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.8421% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.4110% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.1892% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.5294% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.2857% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.4110% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 80.4878% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.6154% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.4878% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.1892% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.1892% (minimum 99%, Baseline (adaptation disabled)); liver: 88.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 86.8421% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.6154% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.6154% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.5000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.9577% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.1573% (minimum 97%, Baseline (adaptation disabled)); retina: 74.1573% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 86.8421% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.9577% (minimum 99%, Baseline (adaptation disabled)); skin: 70.2128% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.4878% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.5714% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.7143% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.4103% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.7143% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.9577% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.5443% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7,3.4,5.1,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); lymph node: 3.4 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000146263,MMS22L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.385897,-0.31,-0.504706
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Missing); adrenal gland: 86.8421% (minimum 99%, Missing); amygdala: 90.4110% (minimum 99%, Missing); basal ganglia: 89.1892% (minimum 99%, Missing); bone marrow: 48.5294% (minimum 99%, Missing); cerebellum: 94.2857% (minimum 99%, Missing); cerebral cortex: 90.4110% (minimum 99%, Missing); choroid plexus: 91.6667% (minimum 99%, Missing); colon: 80.4878% (minimum 97%, Missing); duodenum: 84.6154% (minimum 99%, Missing); esophagus: 80.4878% (minimum 97%, Missing); heart muscle: 91.6667% (minimum 99%, Missing); hippocampal formation: 88.0000% (minimum 99%, Missing); hypothalamus: 89.1892% (minimum 99%, Missing); kidney: 89.1892% (minimum 99%, Missing); liver: 88.0000% (minimum 99%, Missing); lung: 86.8421% (minimum 99%, Missing); lymph node: 66.0000% (minimum 97%, Missing); midbrain: 84.6154% (minimum 99%, Missing); pancreas: 84.6154% (minimum 99%, Missing); parathyroid gland: 82.5000% (minimum 97%, Missing); pituitary gland: 92.9577% (minimum 99%, Missing); rectum: 74.1573% (minimum 97%, Missing); retina: 74.1573% (minimum 99%, Missing); salivary gland: 86.8421% (minimum 97%, Missing); skeletal muscle: 92.9577% (minimum 99%, Missing); skin: 70.2128% (minimum 95%, Missing); small intestine: 80.4878% (minimum 99%, Missing); smooth muscle: 82.5000% (minimum 99%, Missing); spinal cord: 78.5714% (minimum 99%, Missing); spleen: 82.5000% (minimum 95%, Missing); stomach: 85.7143% (minimum 97%, Missing); thymus: 56.4103% (minimum 95%, Missing); thyroid gland: 85.7143% (minimum 95%, Missing); tongue: 92.9577% (minimum 97%, Missing); urinary bladder: 83.5443% (minimum 97%, Missing)",0,80,unavailable,7,3.4,5.1,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); lymph node: 3.4 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000146263,MMS22L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.385897,-0.31,-0.504706
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,23.9,0.1,0.1,"retina: 23.9 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000146276,GABRR1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"choroid plexus: 90.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.0000% (minimum 97%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 3.6290% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 90.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 90.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 90.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,23.9,0.1,0.1,"retina: 23.9 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000146276,GABRR1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.05,-0.07,-0.95371
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"choroid plexus: 90.0000% (minimum 99%, Missing); esophagus: 90.0000% (minimum 97%, Missing); kidney: 75.0000% (minimum 99%, Missing); retina: 3.6290% (minimum 99%, Missing); skeletal muscle: 90.0000% (minimum 99%, Missing); skin: 90.0000% (minimum 95%, Missing); urinary bladder: 90.0000% (minimum 97%, Missing)",0,80,unavailable,23.9,0.1,0.1,"retina: 23.9 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000146276,GABRR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.05,-0.07,-0.95371
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000146378,TAAR2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000146378,TAAR2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000146378,TAAR2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,16.1,6.2,6,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); thymus: 6 nTPM (manageable, limit 5); rectum: 3.6 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000146410,MTFR2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.1507% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7746% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.7746% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 29.6943% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.1507% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.7746% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.5507% (minimum 99%, Baseline (adaptation disabled)); colon: 70.8333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.5789% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.1183% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.7746% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.4444% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.7746% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.1507% (minimum 99%, Baseline (adaptation disabled)); liver: 94.4444% (minimum 99%, Baseline (adaptation disabled)); lung: 86.0759% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.3077% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.1507% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.4444% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.4444% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.3846% (minimum 97%, Baseline (adaptation disabled)); retina: 93.1507% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.4737% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.0759% (minimum 99%, Baseline (adaptation disabled)); skin: 78.1609% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.5556% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.1795% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.4444% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.5556% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.0759% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.1250% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 89.4737% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,16.1,6.2,6,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); thymus: 6 nTPM (manageable, limit 5); rectum: 3.6 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000146410,MTFR2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.41875,-0.446923,-0.693057
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.1507% (minimum 98%, Approved); amygdala: 95.7746% (minimum 99%, Missing); basal ganglia: 95.7746% (minimum 99%, Missing); bone marrow: 29.6943% (minimum 99%, Missing); cerebellum: 93.1507% (minimum 98%, Approved); cerebral cortex: 95.7746% (minimum 98%, Approved); choroid plexus: 98.5507% (minimum 99%, Missing); colon: 70.8333% (minimum 97%, Missing); duodenum: 71.5789% (minimum 99%, Missing); esophagus: 73.1183% (minimum 95%, Approved); heart muscle: 95.7746% (minimum 98%, Approved); hippocampal formation: 94.4444% (minimum 99%, Missing); hypothalamus: 95.7746% (minimum 99%, Missing); kidney: 93.1507% (minimum 98%, Approved); liver: 94.4444% (minimum 98%, Approved); lung: 86.0759% (minimum 98%, Approved); lymph node: 52.3077% (minimum 97%, Missing); midbrain: 93.1507% (minimum 99%, Missing); pancreas: 94.4444% (minimum 98%, Approved); pituitary gland: 94.4444% (minimum 99%, Missing); rectum: 65.3846% (minimum 97%, Missing); retina: 93.1507% (minimum 99%, Missing); salivary gland: 89.4737% (minimum 95%, Approved); skeletal muscle: 86.0759% (minimum 98%, Approved); skin: 78.1609% (minimum 90%, Approved); small intestine: 75.5556% (minimum 99%, Missing); smooth muscle: 87.1795% (minimum 98%, Approved); spinal cord: 94.4444% (minimum 99%, Missing); spleen: 75.5556% (minimum 90%, Approved); stomach: 86.0759% (minimum 97%, Missing); thymus: 53.1250% (minimum 95%, Missing); urinary bladder: 89.4737% (minimum 97%, Missing)",0,0,routine_complete,16.1,6.2,6,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); thymus: 6 nTPM (manageable, limit 5); rectum: 3.6 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000146410,MTFR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.41875,-0.446923,-0.693057
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,3.6,0.4,1,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000146453,PNLDC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.5309% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.0476% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.6957% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.7500% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.3415% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.4433% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.7500% (minimum 99%, Baseline (adaptation disabled)); colon: 96.3415% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.5309% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.9412% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.3415% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5309% (minimum 99%, Baseline (adaptation disabled)); liver: 94.0476% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5309% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.1807% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.1807% (minimum 99%, Baseline (adaptation disabled)); pancreas: 83.1579% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.3415% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7500% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.7500% (minimum 99%, Baseline (adaptation disabled)); skin: 88.7640% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.7500% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.0476% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,3.6,0.4,1,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000146453,PNLDC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,-0.0623596,-0.0181928,-0.303043
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.5309% (minimum 99%, Missing); amygdala: 94.0476% (minimum 99%, Missing); basal ganglia: 68.6957% (minimum 99%, Missing); bone marrow: 98.7500% (minimum 99%, Uncertain); cerebellum: 96.3415% (minimum 99%, Missing); cerebral cortex: 81.4433% (minimum 99%, Missing); choroid plexus: 98.7500% (minimum 99%, Missing); colon: 96.3415% (minimum 97%, Missing); heart muscle: 97.5309% (minimum 99%, Uncertain); hippocampal formation: 92.9412% (minimum 99%, Missing); hypothalamus: 96.3415% (minimum 99%, Missing); kidney: 97.5309% (minimum 99%, Missing); liver: 94.0476% (minimum 99%, Uncertain); lung: 97.5309% (minimum 99%, Missing); lymph node: 95.1807% (minimum 97%, Uncertain); midbrain: 95.1807% (minimum 99%, Missing); pancreas: 83.1579% (minimum 99%, Missing); pituitary gland: 96.3415% (minimum 99%, Missing); retina: 98.7500% (minimum 99%, Missing); skeletal muscle: 98.7500% (minimum 99%, Uncertain); skin: 88.7640% (minimum 95%, Missing); small intestine: 98.7500% (minimum 99%, Missing); spinal cord: 94.0476% (minimum 99%, Missing)",0,1,partial,3.6,0.4,1,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000146453,PNLDC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,-0.0623596,-0.0181928,-0.303043
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,13,partial,52.7,16.6,26.8,"bone marrow: 52.7 nTPM (vital, limit 1); thymus: 26.8 nTPM (manageable, limit 5); lymph node: 16.6 nTPM (protected, limit 2); esophagus: 9.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6.6 nTPM (protected, limit 2); spleen: 6.4 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000146670,CDCA5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.8421% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.6127% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.1333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 41.1173% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.8723% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.1646% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.3545% (minimum 99%, Baseline (adaptation disabled)); colon: 84.7926% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.7925% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.1743% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.6127% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6127% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.1333% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.6127% (minimum 99%, Baseline (adaptation disabled)); liver: 96.5879% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0904% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.9139% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.6127% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.6595% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.2579% (minimum 97%, Baseline (adaptation disabled)); retina: 98.6595% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.3351% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.3957% (minimum 99%, Baseline (adaptation disabled)); skin: 89.9756% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.5882% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.4623% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.3957% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.1852% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.2306% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.8616% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.6015% (minimum 97%, Baseline (adaptation disabled))",0,13,partial,52.7,16.6,26.8,"bone marrow: 52.7 nTPM (vital, limit 1); thymus: 26.8 nTPM (manageable, limit 5); lymph node: 16.6 nTPM (protected, limit 2); esophagus: 9.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6.6 nTPM (protected, limit 2); spleen: 6.4 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); smooth muscle: 3 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000146670,CDCA5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.371384,-0.280861,-0.578827
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.8421% (minimum 99%, Missing); amygdala: 97.6127% (minimum 99%, Missing); basal ganglia: 98.1333% (minimum 99%, Missing); bone marrow: 41.1173% (minimum 99%, Missing); cerebellum: 97.8723% (minimum 99%, Missing); cerebral cortex: 93.1646% (minimum 99%, Missing); choroid plexus: 97.3545% (minimum 99%, Missing); colon: 84.7926% (minimum 97%, Missing); duodenum: 86.7925% (minimum 99%, Missing); esophagus: 80.1743% (minimum 97%, Missing); hippocampal formation: 97.6127% (minimum 99%, Missing); hypothalamus: 98.1333% (minimum 99%, Missing); kidney: 97.6127% (minimum 99%, Missing); lymph node: 68.9139% (minimum 97%, Missing); midbrain: 97.6127% (minimum 99%, Missing); pancreas: 98.1333% (minimum 99%, Missing); pituitary gland: 98.6595% (minimum 99%, Missing); rectum: 83.2579% (minimum 97%, Missing); retina: 98.6595% (minimum 99%, Missing); salivary gland: 96.3351% (minimum 97%, Missing); skeletal muscle: 98.3957% (minimum 99%, Missing); skin: 89.9756% (minimum 95%, Missing); small intestine: 86.5882% (minimum 99%, Missing); smooth muscle: 92.4623% (minimum 95%, Enhanced); spinal cord: 98.3957% (minimum 99%, Missing); spleen: 85.1852% (minimum 95%, Missing); stomach: 92.2306% (minimum 97%, Missing); thymus: 57.8616% (minimum 95%, Missing); urinary bladder: 94.6015% (minimum 97%, Missing)",0,13,partial,52.7,16.6,26.8,"bone marrow: 52.7 nTPM (vital, limit 1); thymus: 26.8 nTPM (manageable, limit 5); lymph node: 16.6 nTPM (protected, limit 2); esophagus: 9.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6.6 nTPM (protected, limit 2); spleen: 6.4 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000146670,CDCA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.371384,-0.280861,-0.578827
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,13,8.5,6.8,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); heart muscle: 7.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 2); parathyroid gland: 6.6 nTPM (protected, limit 2); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 2); lymph node: 5.1 nTPM (protected, limit 4); urinary bladder: 5 nTPM (protected, limit 2); smooth muscle: 4.9 nTPM (vital, limit 2); colon: 4.8 nTPM (protected, limit 2); skeletal muscle: 4.5 nTPM (vital, limit 2); salivary gland: 4.3 nTPM (protected, limit 2); rectum: 4.3 nTPM (protected, limit 2); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 2); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000146733,PSPH,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.1845% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.3466% (minimum 99%, Baseline (adaptation disabled)); amygdala: 60.2273% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.3830% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.7107% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.0441% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.2273% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 55.0173% (minimum 99%, Baseline (adaptation disabled)); colon: 76.8116% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.1045% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.1639% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.8067% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 62.3529% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.8458% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.1094% (minimum 99%, Baseline (adaptation disabled)); liver: 70.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 82.3834% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.7143% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.8677% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.9821% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.3466% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.7129% (minimum 97%, Baseline (adaptation disabled)); retina: 79.1045% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.7129% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.9412% (minimum 99%, Baseline (adaptation disabled)); skin: 79.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.8995% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.4423% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.4007% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.7107% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.6027% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.6216% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.0441% (minimum 95%, Baseline (adaptation disabled)); tongue: 71.3004% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.0766% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,13,8.5,6.8,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); heart muscle: 7.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 2); lymph node: 5.1 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 2); smooth muscle: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); skeletal muscle: 4.5 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 2); rectum: 4.3 nTPM (protected, limit 2); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000146733,PSPH,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.249559,-0.318361,-0.439827
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.1845% (minimum 90%, Approved); adrenal gland: 63.3466% (minimum 99%, Missing); amygdala: 60.2273% (minimum 99%, Missing); basal ganglia: 56.3830% (minimum 99%, Missing); bone marrow: 80.7107% (minimum 98%, Approved); cerebellum: 70.0441% (minimum 99%, Missing); cerebral cortex: 60.2273% (minimum 99%, Missing); choroid plexus: 55.0173% (minimum 99%, Missing); colon: 76.8116% (minimum 97%, Missing); duodenum: 79.1045% (minimum 99%, Missing); esophagus: 65.1639% (minimum 97%, Missing); heart muscle: 66.8067% (minimum 99%, Missing); hippocampal formation: 62.3529% (minimum 99%, Missing); hypothalamus: 62.8458% (minimum 99%, Missing); kidney: 62.1094% (minimum 99%, Missing); liver: 70.6667% (minimum 98%, Approved); lung: 82.3834% (minimum 99%, Missing); lymph node: 75.7143% (minimum 95%, Approved); midbrain: 61.8677% (minimum 99%, Missing); pancreas: 70.9821% (minimum 99%, Missing); parathyroid gland: 70.6667% (minimum 97%, Missing); pituitary gland: 63.3466% (minimum 99%, Missing); rectum: 78.7129% (minimum 97%, Missing); retina: 79.1045% (minimum 99%, Missing); salivary gland: 78.7129% (minimum 97%, Missing); skeletal muscle: 77.9412% (minimum 98%, Approved); skin: 79.5000% (minimum 95%, Missing); small intestine: 79.8995% (minimum 99%, Missing); smooth muscle: 76.4423% (minimum 98%, Approved); spinal cord: 57.4007% (minimum 99%, Missing); spleen: 80.7107% (minimum 90%, Approved); stomach: 72.6027% (minimum 97%, Missing); thymus: 71.6216% (minimum 95%, Missing); thyroid gland: 70.0441% (minimum 95%, Missing); tongue: 71.3004% (minimum 97%, Missing); urinary bladder: 76.0766% (minimum 97%, Missing)",0,4,partial,13,8.5,6.8,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); heart muscle: 7.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 2); parathyroid gland: 6.6 nTPM (protected, limit 2); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 2); lymph node: 5.1 nTPM (protected, limit 4); urinary bladder: 5 nTPM (protected, limit 2); smooth muscle: 4.9 nTPM (vital, limit 2); colon: 4.8 nTPM (protected, limit 2); skeletal muscle: 4.5 nTPM (vital, limit 2); salivary gland: 4.3 nTPM (protected, limit 2); rectum: 4.3 nTPM (protected, limit 2); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 2); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000146733,PSPH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.249559,-0.318361,-0.439827
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000146839,ZAN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000146839,ZAN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000146839,ZAN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,84.5,20.1,34.5,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (manageable, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); spleen: 27.1 nTPM (manageable, limit 5); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 2); lymph node: 19.7 nTPM (protected, limit 2); adrenal gland: 18.6 nTPM (vital, limit 1); duodenum: 17.3 nTPM (vital, limit 1); salivary gland: 17 nTPM (protected, limit 2); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 2); urinary bladder: 16 nTPM (protected, limit 2); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 2); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); skin: 8.9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 2); rectum: 8.1 nTPM (protected, limit 2); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000146859,TMEM140,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.2649% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 59.5652% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.0651% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.4821% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 71.7277% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.4011% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.2827% (minimum 99%, Baseline (adaptation disabled)); colon: 62.2727% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.2975% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.4821% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 47.9860% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.6594% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.4203% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.9294% (minimum 99%, Baseline (adaptation disabled)); liver: 34.5088% (minimum 99%, Baseline (adaptation disabled)); lung: 47.9021% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.1741% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.9927% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.5502% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.9463% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.3077% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.1831% (minimum 97%, Baseline (adaptation disabled)); retina: 90.4290% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.7117% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 24.4861% (minimum 99%, Baseline (adaptation disabled)); skin: 75.4821% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.1315% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.0667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.6204% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.2752% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.1919% (minimum 97%, Baseline (adaptation disabled)); thymus: 81.3056% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 72.1053% (minimum 95%, Baseline (adaptation disabled)); tongue: 57.6842% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.1336% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,84.5,20.1,34.5,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (manageable, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); spleen: 27.1 nTPM (manageable, limit 5); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 2); lymph node: 19.7 nTPM (protected, limit 2); adrenal gland: 18.6 nTPM (vital, limit 1); duodenum: 17.3 nTPM (vital, limit 1); salivary gland: 17 nTPM (protected, limit 2); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 2); urinary bladder: 16 nTPM (protected, limit 2); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 2); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); skin: 8.9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 2); rectum: 8.1 nTPM (protected, limit 2); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000146859,TMEM140,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.507351,-0.393158,-0.745139
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.2649% (minimum 95%, Missing); adrenal gland: 59.5652% (minimum 99%, Missing); amygdala: 81.0651% (minimum 99%, Missing); basal ganglia: 75.4821% (minimum 99%, Missing); bone marrow: 71.7277% (minimum 99%, Missing); cerebellum: 91.3333% (minimum 99%, Missing); cerebral cortex: 77.4011% (minimum 99%, Missing); choroid plexus: 83.2827% (minimum 99%, Missing); colon: 62.2727% (minimum 97%, Missing); duodenum: 61.2975% (minimum 99%, Missing); esophagus: 75.4821% (minimum 97%, Missing); heart muscle: 47.9860% (minimum 99%, Missing); hippocampal formation: 74.6594% (minimum 99%, Missing); hypothalamus: 79.4203% (minimum 99%, Missing); kidney: 50.9294% (minimum 99%, Missing); liver: 34.5088% (minimum 99%, Missing); lung: 47.9021% (minimum 99%, Missing); lymph node: 58.1741% (minimum 97%, Missing); midbrain: 66.9927% (minimum 99%, Missing); pancreas: 65.5502% (minimum 99%, Missing); parathyroid gland: 91.9463% (minimum 97%, Missing); pituitary gland: 84.3077% (minimum 99%, Missing); rectum: 77.1831% (minimum 97%, Missing); retina: 90.4290% (minimum 99%, Missing); salivary gland: 61.7117% (minimum 97%, Missing); skeletal muscle: 24.4861% (minimum 99%, Missing); skin: 75.4821% (minimum 95%, Missing); small intestine: 62.1315% (minimum 99%, Missing); smooth muscle: 73.0667% (minimum 99%, Missing); spinal cord: 53.6204% (minimum 99%, Missing); spleen: 50.2752% (minimum 95%, Missing); stomach: 69.1919% (minimum 97%, Missing); thymus: 81.3056% (minimum 95%, Missing); thyroid gland: 72.1053% (minimum 95%, Missing); tongue: 57.6842% (minimum 97%, Missing); urinary bladder: 63.1336% (minimum 97%, Missing)",0,80,unavailable,84.5,20.1,34.5,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (manageable, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); spleen: 27.1 nTPM (manageable, limit 5); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 2); lymph node: 19.7 nTPM (protected, limit 2); adrenal gland: 18.6 nTPM (vital, limit 1); duodenum: 17.3 nTPM (vital, limit 1); salivary gland: 17 nTPM (protected, limit 2); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 2); urinary bladder: 16 nTPM (protected, limit 2); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 2); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); skin: 8.9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 2); rectum: 8.1 nTPM (protected, limit 2); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000146859,TMEM140,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.507351,-0.393158,-0.745139
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,24.1,12.1,27.2,"thymus: 27.2 nTPM (manageable, limit 5); bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); esophagus: 6.7 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000146918,NCAPG2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.7059% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 37.4026% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.2071% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.3559% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.7197% (minimum 99%, Baseline (adaptation disabled)); colon: 68.2464% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.0053% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.2464% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.7209% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.7059% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.8049% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.2071% (minimum 99%, Baseline (adaptation disabled)); liver: 78.2609% (minimum 99%, Baseline (adaptation disabled)); lung: 82.7586% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.3396% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.2275% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.2727% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 76.1905% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.8989% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.0550% (minimum 97%, Baseline (adaptation disabled)); retina: 84.2105% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.8989% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.3559% (minimum 99%, Baseline (adaptation disabled)); skin: 68.5714% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.3927% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.7586% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.5957% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.7273% (minimum 97%, Baseline (adaptation disabled)); thymus: 34.6154% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.2857% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.6885% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.6885% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,24.1,12.1,27.2,"thymus: 27.2 nTPM (manageable, limit 5); bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); esophagus: 6.7 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000146918,NCAPG2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.603846,-0.426604,-0.615974
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 90%, Approved); adrenal gland: 85.7143% (minimum 99%, Missing); amygdala: 85.7143% (minimum 99%, Missing); basal ganglia: 84.7059% (minimum 99%, Missing); bone marrow: 37.4026% (minimum 99%, Missing); cerebellum: 85.2071% (minimum 99%, Missing); cerebral cortex: 81.3559% (minimum 99%, Missing); choroid plexus: 91.7197% (minimum 99%, Missing); colon: 68.2464% (minimum 97%, Missing); duodenum: 77.0053% (minimum 99%, Missing); esophagus: 68.2464% (minimum 97%, Missing); heart muscle: 83.7209% (minimum 99%, Missing); hippocampal formation: 84.7059% (minimum 99%, Missing); hypothalamus: 87.8049% (minimum 99%, Missing); kidney: 85.2071% (minimum 99%, Missing); liver: 78.2609% (minimum 99%, Missing); lung: 82.7586% (minimum 99%, Missing); lymph node: 54.3396% (minimum 97%, Missing); midbrain: 86.2275% (minimum 99%, Missing); pancreas: 87.2727% (minimum 99%, Missing); parathyroid gland: 76.1905% (minimum 97%, Missing); pituitary gland: 80.8989% (minimum 99%, Missing); rectum: 66.0550% (minimum 97%, Missing); retina: 84.2105% (minimum 99%, Missing); salivary gland: 80.8989% (minimum 97%, Missing); skeletal muscle: 81.3559% (minimum 99%, Missing); skin: 68.5714% (minimum 95%, Missing); small intestine: 72.0000% (minimum 99%, Missing); smooth muscle: 75.3927% (minimum 99%, Missing); spinal cord: 82.7586% (minimum 99%, Missing); spleen: 76.5957% (minimum 95%, Missing); stomach: 72.7273% (minimum 97%, Missing); thymus: 34.6154% (minimum 95%, Missing); thyroid gland: 82.2857% (minimum 95%, Missing); tongue: 78.6885% (minimum 97%, Missing); urinary bladder: 78.6885% (minimum 97%, Missing)",0,1,partial,24.1,12.1,27.2,"thymus: 27.2 nTPM (manageable, limit 5); bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 2); rectum: 7.4 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); esophagus: 6.7 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000146918,NCAPG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.603846,-0.426604,-0.615974
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000147081,AKAP4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000147081,AKAP4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000147081,AKAP4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.5,0.4,0.3,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000147082,CCNB3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.4426% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.4426% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.6102% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.4426% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.4426% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2759% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.4762% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.0625% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.9355% (minimum 99%, Baseline (adaptation disabled)); liver: 93.4426% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 82.6087% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.4426% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 89.0625% (minimum 99%, Baseline (adaptation disabled)); retina: 91.9355% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 93.4426% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2759% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.5122% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.4426% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.5,0.4,0.3,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000147082,CCNB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,1.11022e-16,-0.0355738,-0.294878
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.0000% (minimum 99%, Missing); amygdala: 93.4426% (minimum 99%, Missing); basal ganglia: 93.4426% (minimum 99%, Missing); cerebellum: 96.6102% (minimum 99%, Missing); cerebral cortex: 93.4426% (minimum 99%, Missing); choroid plexus: 93.4426% (minimum 99%, Missing); heart muscle: 98.2759% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 89.0625% (minimum 99%, Missing); kidney: 91.9355% (minimum 99%, Missing); liver: 93.4426% (minimum 99%, Missing); lung: 95.0000% (minimum 99%, Missing); midbrain: 82.6087% (minimum 99%, Missing); pancreas: 93.4426% (minimum 99%, Missing); pituitary gland: 89.0625% (minimum 99%, Missing); retina: 91.9355% (minimum 99%, Missing); skeletal muscle: 93.4426% (minimum 99%, Missing); small intestine: 98.2759% (minimum 99%, Missing); spinal cord: 69.5122% (minimum 99%, Missing); stomach: 93.4426% (minimum 97%, Missing)",0,80,unavailable,2.5,0.4,0.3,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000147082,CCNB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,1.11022e-16,-0.0355738,-0.294878
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,56,0.3,0.3,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000147127,RAB41,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.1220% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.9091% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.7826% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.5849% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 92.8571% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.5000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.1220% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.5918% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.4706% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.1220% (minimum 99%, Baseline (adaptation disabled)); liver: 97.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 72.2222% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.5000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.1220% (minimum 99%, Baseline (adaptation disabled)); retina: 6.5109% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.1220% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 92.8571% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.6977% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.0000% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 95.1220% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,56,0.3,0.3,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000147127,RAB41,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0214286,-0.0414286,-0.924891
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.1220% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 70.9091% (minimum 99%, Missing); bone marrow: 97.5000% (minimum 99%, Missing); cerebellum: 84.7826% (minimum 99%, Missing); cerebral cortex: 73.5849% (minimum 99%, Missing); choroid plexus: 97.5000% (minimum 99%, Missing); colon: 92.8571% (minimum 97%, Missing); duodenum: 97.5000% (minimum 99%, Missing); heart muscle: 95.1220% (minimum 99%, Missing); hippocampal formation: 79.5918% (minimum 99%, Missing); hypothalamus: 76.4706% (minimum 99%, Missing); kidney: 95.1220% (minimum 99%, Missing); liver: 97.5000% (minimum 99%, Missing); lung: 97.5000% (minimum 99%, Missing); midbrain: 72.2222% (minimum 99%, Missing); pancreas: 97.5000% (minimum 99%, Missing); pituitary gland: 95.1220% (minimum 99%, Missing); retina: 6.5109% (minimum 99%, Missing); salivary gland: 95.1220% (minimum 97%, Missing); skeletal muscle: 97.5000% (minimum 99%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 90.6977% (minimum 99%, Missing); spinal cord: 78.0000% (minimum 99%, Missing); urinary bladder: 95.1220% (minimum 97%, Missing)",0,80,unavailable,56,0.3,0.3,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000147127,RAB41,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0214286,-0.0414286,-0.924891
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,18.3,4,15.9,"cerebral cortex: 18.3 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 6); midbrain: 7 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000147180,ZNF711,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.1198% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.0885% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.9005% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.6028% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.3713% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.4220% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.7914% (minimum 99%, Baseline (adaptation disabled)); colon: 91.1839% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.3469% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.5401% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.9548% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.5315% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.0885% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.8641% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6376% (minimum 99%, Baseline (adaptation disabled)); lung: 95.5145% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.0260% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.7963% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.5086% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.5333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.3504% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.5145% (minimum 97%, Baseline (adaptation disabled)); retina: 86.8106% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.0498% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.0212% (minimum 99%, Baseline (adaptation disabled)); skin: 75.4167% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.9435% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.1120% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.7963% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.0779% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.2990% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.4818% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.2927% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.0212% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.5831% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,18.3,4,15.9,"cerebral cortex: 18.3 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); stomach: 2.6 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000147180,ZNF711,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.255182,-0.0695025,-0.32578
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.1198% (minimum 99%, Missing); amygdala: 80.0885% (minimum 99%, Missing); basal ganglia: 81.9005% (minimum 99%, Missing); bone marrow: 83.6028% (minimum 95%, Enhanced); cerebellum: 76.3713% (minimum 99%, Missing); cerebral cortex: 66.4220% (minimum 99%, Missing); choroid plexus: 96.7914% (minimum 99%, Missing); colon: 91.1839% (minimum 97%, Missing); duodenum: 92.3469% (minimum 99%, Missing); heart muscle: 90.9548% (minimum 99%, Missing); hippocampal formation: 81.5315% (minimum 99%, Missing); hypothalamus: 80.0885% (minimum 99%, Missing); kidney: 87.8641% (minimum 99%, Missing); lung: 95.5145% (minimum 99%, Missing); midbrain: 83.7963% (minimum 99%, Missing); pancreas: 88.5086% (minimum 95%, Enhanced); pituitary gland: 77.3504% (minimum 99%, Missing); rectum: 95.5145% (minimum 97%, Missing); retina: 86.8106% (minimum 99%, Missing); small intestine: 88.9435% (minimum 99%, Missing); smooth muscle: 92.1120% (minimum 95%, Enhanced); spinal cord: 83.7963% (minimum 99%, Missing); thymus: 69.4818% (minimum 95%, Missing); tongue: 96.0212% (minimum 97%, Missing); urinary bladder: 92.5831% (minimum 97%, Missing)",0,6,partial,18.3,4,15.9,"cerebral cortex: 18.3 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 6); midbrain: 7 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000147180,ZNF711,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.255182,-0.0581612,-0.32578
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000147183,CPXCR1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000147183,CPXCR1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000147183,CPXCR1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,False,,0,2,partial,4.8,1,0.6,"lung: 4.8 nTPM (vital, limit 2); bone marrow: 3.9 nTPM (vital, limit 2); small intestine: 2.9 nTPM (vital, limit 2)",duodenum / glandular cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen,ENSG00000147206,NXF3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 98.7698% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.5108% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9437% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.0803% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2517% (minimum 99%, Baseline (adaptation disabled)); lung: 92.1311% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.0931% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,4.8,1,0.6,"lung: 4.8 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen,ENSG00000147206,NXF3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0394366,0.0125175,-0.0686885
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"bone marrow: 93.5108% (minimum 98%, Approved); duodenum: 98.9437% (minimum 99%, Missing); lung: 92.1311% (minimum 98%, Approved); small intestine: 95.0931% (minimum 98%, Approved)",0,2,partial,4.8,1,0.6,"lung: 4.8 nTPM (vital, limit 2); bone marrow: 3.9 nTPM (vital, limit 2); small intestine: 2.9 nTPM (vital, limit 2)",duodenum / glandular cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen,ENSG00000147206,NXF3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.0586885
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,13.1,5.7,16.2,"thymus: 16.2 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); salivary gland: 5.7 nTPM (protected, limit 2); adipose tissue: 5.5 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 2); urinary bladder: 5.2 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); spinal cord: 4.6 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000147316,MCPH1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5862% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.8866% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.8866% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 31.7708% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.9633% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.0952% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.7778% (minimum 99%, Baseline (adaptation disabled)); colon: 55.9633% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.6162% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.0093% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.8039% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.6162% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.2105% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.2233% (minimum 99%, Baseline (adaptation disabled)); liver: 61.6162% (minimum 99%, Baseline (adaptation disabled)); lung: 58.6538% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.9823% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.9550% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.3960% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.2449% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.0330% (minimum 97%, Baseline (adaptation disabled)); retina: 58.0952% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.6949% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 39.1026% (minimum 99%, Baseline (adaptation disabled)); skin: 54.9550% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.5472% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.5393% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.0093% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.4545% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.5472% (minimum 97%, Baseline (adaptation disabled)); thymus: 27.3543% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.5472% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.2449% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.9823% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,13.1,5.7,16.2,"thymus: 16.2 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); salivary gland: 5.7 nTPM (protected, limit 2); adipose tissue: 5.5 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 2); urinary bladder: 5.2 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); spinal cord: 4.6 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000147316,MCPH1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.676457,-0.453051,-0.672292
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5862% (minimum 95%, Missing); adrenal gland: 62.8866% (minimum 99%, Missing); amygdala: 62.8866% (minimum 99%, Missing); basal ganglia: 61.0000% (minimum 99%, Missing); bone marrow: 31.7708% (minimum 99%, Missing); cerebellum: 55.9633% (minimum 99%, Missing); cerebral cortex: 58.0952% (minimum 99%, Missing); choroid plexus: 67.7778% (minimum 99%, Missing); colon: 55.9633% (minimum 97%, Missing); duodenum: 61.6162% (minimum 99%, Missing); esophagus: 57.0093% (minimum 97%, Missing); heart muscle: 59.8039% (minimum 99%, Missing); hippocampal formation: 61.6162% (minimum 99%, Missing); hypothalamus: 64.2105% (minimum 99%, Missing); kidney: 59.2233% (minimum 99%, Missing); liver: 61.6162% (minimum 99%, Missing); lung: 58.6538% (minimum 99%, Missing); lymph node: 53.9823% (minimum 97%, Missing); midbrain: 61.0000% (minimum 99%, Missing); pancreas: 54.9550% (minimum 99%, Missing); parathyroid gland: 60.3960% (minimum 97%, Missing); pituitary gland: 62.2449% (minimum 99%, Missing); rectum: 67.0330% (minimum 97%, Missing); retina: 58.0952% (minimum 99%, Missing); salivary gland: 51.6949% (minimum 97%, Missing); skeletal muscle: 39.1026% (minimum 99%, Missing); skin: 54.9550% (minimum 95%, Missing); small intestine: 57.5472% (minimum 99%, Missing); smooth muscle: 68.5393% (minimum 99%, Missing); spinal cord: 57.0093% (minimum 99%, Missing); spleen: 55.4545% (minimum 95%, Missing); stomach: 57.5472% (minimum 97%, Missing); thymus: 27.3543% (minimum 95%, Missing); thyroid gland: 57.5472% (minimum 95%, Missing); tongue: 62.2449% (minimum 97%, Missing); urinary bladder: 53.9823% (minimum 97%, Missing)",0,4,partial,13.1,5.7,16.2,"thymus: 16.2 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); salivary gland: 5.7 nTPM (protected, limit 2); adipose tissue: 5.5 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 2); urinary bladder: 5.2 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); esophagus: 4.6 nTPM (protected, limit 2); spinal cord: 4.6 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); small intestine: 4.5 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000147316,MCPH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.676457,-0.453051,-0.672292
True,compatible,,True,True,False,,0,2,partial,0.9,0.3,2.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000147378,FATE1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.9,0.3,2.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000147378,FATE1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.0406183,0.0287102,0.00614065
True,compatible,,True,True,True,,0,2,partial,0.9,0.3,2.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000147378,FATE1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.0406183,0.0287102,0.00785223
True,compatible,,True,True,False,,0,2,partial,0.1,0.6,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000147381,MAGEA4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.1,0.6,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000147381,MAGEA4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,0.0453704,0.00285068,0.00537037
True,compatible,,True,True,True,,0,2,partial,0.1,0.6,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000147381,MAGEA4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,5.7,5,6,"thymus: 6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000147536,GINS4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.8485% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.8485% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 32.9412% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.3226% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.6757% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 58.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.1163% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.6364% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.3529% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.3529% (minimum 99%, Baseline (adaptation disabled)); liver: 68.2927% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 35.8974% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.3529% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.7778% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.3529% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 49.1228% (minimum 97%, Baseline (adaptation disabled)); retina: 77.7778% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.8485% (minimum 99%, Baseline (adaptation disabled)); skin: 58.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.6364% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.6842% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.6364% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 31.8182% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.5517% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.7949% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,5.7,5,6,"thymus: 6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000147536,GINS4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.631818,-0.611026,-0.660588
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Missing); adrenal gland: 80.0000% (minimum 99%, Missing); amygdala: 84.8485% (minimum 99%, Missing); basal ganglia: 84.8485% (minimum 99%, Missing); bone marrow: 32.9412% (minimum 99%, Missing); cerebellum: 90.3226% (minimum 99%, Missing); cerebral cortex: 75.6757% (minimum 99%, Missing); choroid plexus: 80.0000% (minimum 99%, Missing); colon: 58.3333% (minimum 97%, Missing); duodenum: 65.1163% (minimum 99%, Missing); esophagus: 63.6364% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 82.3529% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); kidney: 82.3529% (minimum 99%, Missing); liver: 68.2927% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 35.8974% (minimum 97%, Missing); midbrain: 82.3529% (minimum 99%, Missing); pancreas: 77.7778% (minimum 99%, Missing); parathyroid gland: 82.3529% (minimum 97%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); rectum: 49.1228% (minimum 97%, Missing); retina: 77.7778% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 84.8485% (minimum 99%, Missing); skin: 58.3333% (minimum 95%, Missing); small intestine: 63.6364% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 73.6842% (minimum 99%, Missing); spleen: 63.6364% (minimum 95%, Missing); stomach: 70.0000% (minimum 97%, Missing); thymus: 31.8182% (minimum 95%, Missing); thyroid gland: 70.0000% (minimum 95%, Missing); tongue: 96.5517% (minimum 97%, Missing); urinary bladder: 71.7949% (minimum 97%, Missing)",0,1,partial,5.7,5,6,"thymus: 6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000147536,GINS4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.631818,-0.611026,-0.660588
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.9,7.5,1.4,"lymph node: 7.5 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000147570,DNAJC5B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 98.2998% (minimum 99%, Baseline (adaptation disabled)); liver: 97.5460% (minimum 99%, Baseline (adaptation disabled)); lung: 91.5108% (minimum 99%, Baseline (adaptation disabled)); lymph node: 89.4515% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.9114% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.8462% (minimum 99%, Baseline (adaptation disabled)); tongue: 95.3523% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.9,7.5,1.4,"lymph node: 7.5 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000147570,DNAJC5B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025,0.0284615,-0.0754852,-0.0748921
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 98.2998% (minimum 99%, Missing); liver: 97.5460% (minimum 99%, Missing); lung: 91.5108% (minimum 99%, Missing); lymph node: 89.4515% (minimum 97%, Missing); skeletal muscle: 98.9114% (minimum 99%, Missing); small intestine: 97.8462% (minimum 99%, Missing); tongue: 95.3523% (minimum 97%, Missing)",0,80,unavailable,5.9,7.5,1.4,"lymph node: 7.5 nTPM (protected, limit 2); lung: 5.9 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000147570,DNAJC5B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025,0.0284615,-0.0754852,-0.0748921
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,46,0.6,1.5,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000147571,CRH,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.9231% (minimum 99%, Baseline (adaptation disabled)); amygdala: 52.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.9485% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.4375% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 35.3933% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.9231% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.7647% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 12.0459% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.4545% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.7692% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.3043% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.9231% (minimum 99%, Baseline (adaptation disabled)); retina: 92.6471% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.4375% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.7500% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,46,0.6,1.5,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000147571,CRH,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.142308,-0.0569565,-0.869541
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Missing); adrenal gland: 96.9231% (minimum 99%, Missing); amygdala: 52.5000% (minimum 99%, Missing); basal ganglia: 64.9485% (minimum 99%, Missing); bone marrow: 98.4375% (minimum 99%, Missing); cerebral cortex: 35.3933% (minimum 99%, Missing); choroid plexus: 96.9231% (minimum 99%, Missing); hippocampal formation: 61.7647% (minimum 99%, Missing); hypothalamus: 12.0459% (minimum 99%, Missing); midbrain: 95.4545% (minimum 99%, Missing); pancreas: 80.7692% (minimum 99%, Missing); parathyroid gland: 91.3043% (minimum 97%, Missing); pituitary gland: 96.9231% (minimum 99%, Missing); retina: 92.6471% (minimum 99%, Missing); smooth muscle: 98.4375% (minimum 99%, Missing); spinal cord: 78.7500% (minimum 99%, Missing)",0,80,unavailable,46,0.6,1.5,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000147571,CRH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.142308,-0.0569565,-0.869541
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000147596,PRDM14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 77.7778% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.7778% (minimum 99%, Baseline (adaptation disabled)); duodenum: 87.5000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 87.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 77.7778% (minimum 99%, Baseline (adaptation disabled)); skin: 87.5000% (minimum 95%, Baseline (adaptation disabled)); spleen: 87.5000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000147596,PRDM14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,-0.075,0.03,-0.212222
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 77.7778% (minimum 99%, Missing); choroid plexus: 77.7778% (minimum 99%, Missing); duodenum: 87.5000% (minimum 99%, Missing); heart muscle: 87.5000% (minimum 99%, Missing); kidney: 87.5000% (minimum 99%, Missing); lung: 87.5000% (minimum 99%, Missing); retina: 77.7778% (minimum 99%, Missing); skin: 87.5000% (minimum 95%, Missing); spleen: 87.5000% (minimum 95%, Missing)",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000147596,PRDM14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,-0.075,0.03,-0.212222
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,2.4,0,0,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells,ENSG00000147613,PSKH2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 33.3333% (minimum 99%, Baseline (adaptation disabled)); retina: 4.0000% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,2.4,0,0,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells,ENSG00000147613,PSKH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.95
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 33.3333% (minimum 99%, Missing); retina: 4.0000% (minimum 99%, Missing)",0,5,partial,2.4,0,0,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells,ENSG00000147613,PSKH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.95
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,16.8,11.1,14.7,"bone marrow: 16.8 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 2); retina: 8.7 nTPM (vital, limit 1); skin: 7.9 nTPM (manageable, limit 5); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 2); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); urinary bladder: 5.9 nTPM (protected, limit 2); parathyroid gland: 5.9 nTPM (protected, limit 2); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); cerebellum: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 5.1 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); hypothalamus: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000147874,HAUS6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.0423% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.7162% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.2143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.5125% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 58.1047% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.7544% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.6447% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.2720% (minimum 99%, Baseline (adaptation disabled)); colon: 80.6228% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.6618% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.3322% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.3322% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.9181% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.3480% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.6618% (minimum 99%, Baseline (adaptation disabled)); liver: 77.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 83.5125% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.7326% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.3448% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.9779% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.7945% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.9313% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.5222% (minimum 97%, Baseline (adaptation disabled)); retina: 72.8125% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 84.4203% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.7273% (minimum 99%, Baseline (adaptation disabled)); skin: 74.6795% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.0423% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 77.1523% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.4045% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.7273% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.3158% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.0423% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.1523% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 79.7945% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,16.8,11.1,14.7,"bone marrow: 16.8 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 2); retina: 8.7 nTPM (vital, limit 1); skin: 7.9 nTPM (manageable, limit 5); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 2); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); urinary bladder: 5.9 nTPM (protected, limit 2); parathyroid gland: 5.9 nTPM (protected, limit 2); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); cerebellum: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 5.1 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); hypothalamus: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000147874,HAUS6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.336842,-0.292674,-0.408953
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.0423% (minimum 95%, Missing); adrenal gland: 78.7162% (minimum 99%, Missing); amygdala: 83.2143% (minimum 99%, Missing); basal ganglia: 83.5125% (minimum 99%, Missing); bone marrow: 58.1047% (minimum 99%, Missing); cerebellum: 81.7544% (minimum 99%, Missing); cerebral cortex: 76.6447% (minimum 99%, Missing); choroid plexus: 89.2720% (minimum 99%, Missing); colon: 80.6228% (minimum 97%, Missing); duodenum: 85.6618% (minimum 99%, Missing); esophagus: 82.3322% (minimum 97%, Missing); heart muscle: 82.3322% (minimum 99%, Missing); hippocampal formation: 82.9181% (minimum 99%, Missing); hypothalamus: 85.3480% (minimum 99%, Missing); kidney: 85.6618% (minimum 99%, Missing); liver: 77.6667% (minimum 99%, Missing); lung: 83.5125% (minimum 99%, Missing); lymph node: 67.7326% (minimum 97%, Missing); midbrain: 80.3448% (minimum 99%, Missing); pancreas: 85.9779% (minimum 99%, Missing); parathyroid gland: 79.7945% (minimum 97%, Missing); pituitary gland: 88.9313% (minimum 99%, Missing); rectum: 79.5222% (minimum 97%, Missing); retina: 72.8125% (minimum 99%, Missing); salivary gland: 84.4203% (minimum 97%, Missing); skeletal muscle: 84.7273% (minimum 99%, Missing); skin: 74.6795% (minimum 95%, Missing); small intestine: 82.0423% (minimum 99%, Missing); smooth muscle: 77.1523% (minimum 99%, Missing); spinal cord: 75.4045% (minimum 99%, Missing); spleen: 77.6667% (minimum 95%, Missing); stomach: 84.7273% (minimum 97%, Missing); thymus: 61.3158% (minimum 95%, Missing); thyroid gland: 82.0423% (minimum 95%, Missing); tongue: 77.1523% (minimum 97%, Missing); urinary bladder: 79.7945% (minimum 97%, Missing)",0,4,partial,16.8,11.1,14.7,"bone marrow: 16.8 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 2); retina: 8.7 nTPM (vital, limit 1); skin: 7.9 nTPM (manageable, limit 5); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 2); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 2); urinary bladder: 5.9 nTPM (protected, limit 2); parathyroid gland: 5.9 nTPM (protected, limit 2); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); cerebellum: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 5.1 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); hypothalamus: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000147874,HAUS6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.336842,-0.292674,-0.408953
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,28.7,13.4,9.8,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 2); spleen: 9.8 nTPM (manageable, limit 5); salivary gland: 8.3 nTPM (protected, limit 2); adrenal gland: 7.7 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (manageable, limit 5); colon: 7.2 nTPM (protected, limit 2); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); hippocampal formation: 5.4 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000147912,FBXO10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.9474% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.6923% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.4138% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.4172% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.9204% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.4266% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.6923% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.6772% (minimum 99%, Baseline (adaptation disabled)); colon: 59.3220% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.0656% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.2059% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 73.4266% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 66.0377% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.1818% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.9437% (minimum 99%, Baseline (adaptation disabled)); liver: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 82.6772% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.0377% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.6423% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.1302% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.9437% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 39.6226% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.0656% (minimum 97%, Baseline (adaptation disabled)); retina: 86.7769% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.8511% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 26.7857% (minimum 99%, Baseline (adaptation disabled)); skin: 85.3659% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.5364% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 77.2059% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.7692% (minimum 99%, Baseline (adaptation disabled)); spleen: 51.7241% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.2059% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.6592% (minimum 95%, Baseline (adaptation disabled)); tongue: 43.9331% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.3582% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,28.7,13.4,9.8,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 2); spleen: 9.8 nTPM (manageable, limit 5); salivary gland: 8.3 nTPM (protected, limit 2); adrenal gland: 7.7 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (manageable, limit 5); colon: 7.2 nTPM (protected, limit 2); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); hippocampal formation: 5.4 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000147912,FBXO10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.432759,-0.530669,-0.722143
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.9474% (minimum 95%, Uncertain); adrenal gland: 57.6923% (minimum 99%, Uncertain); amygdala: 72.4138% (minimum 99%, Missing); basal ganglia: 64.4172% (minimum 99%, Missing); bone marrow: 92.9204% (minimum 99%, Uncertain); cerebellum: 73.4266% (minimum 99%, Uncertain); cerebral cortex: 57.6923% (minimum 99%, Uncertain); choroid plexus: 82.6772% (minimum 99%, Missing); colon: 59.3220% (minimum 97%, Missing); duodenum: 86.0656% (minimum 99%, Missing); esophagus: 77.2059% (minimum 97%, Uncertain); heart muscle: 73.4266% (minimum 99%, Uncertain); hippocampal formation: 66.0377% (minimum 99%, Missing); hypothalamus: 68.1818% (minimum 99%, Missing); kidney: 73.9437% (minimum 99%, Uncertain); liver: 75.0000% (minimum 99%, Uncertain); lung: 82.6772% (minimum 99%, Missing); lymph node: 66.0377% (minimum 97%, Uncertain); midbrain: 76.6423% (minimum 99%, Missing); pancreas: 62.1302% (minimum 99%, Uncertain); parathyroid gland: 73.9437% (minimum 97%, Uncertain); pituitary gland: 39.6226% (minimum 99%, Missing); rectum: 86.0656% (minimum 97%, Missing); retina: 86.7769% (minimum 99%, Missing); salivary gland: 55.8511% (minimum 97%, Uncertain); skeletal muscle: 26.7857% (minimum 99%, Uncertain); skin: 85.3659% (minimum 95%, Uncertain); small intestine: 69.5364% (minimum 99%, Missing); smooth muscle: 77.2059% (minimum 99%, Uncertain); spinal cord: 80.7692% (minimum 99%, Missing); spleen: 51.7241% (minimum 95%, Uncertain); stomach: 77.2059% (minimum 97%, Uncertain); thymus: 84.0000% (minimum 95%, Missing); thyroid gland: 58.6592% (minimum 95%, Uncertain); tongue: 43.9331% (minimum 97%, Missing); urinary bladder: 78.3582% (minimum 97%, Uncertain)",0,3,partial,28.7,13.4,9.8,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 2); spleen: 9.8 nTPM (manageable, limit 5); salivary gland: 8.3 nTPM (protected, limit 2); adrenal gland: 7.7 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (manageable, limit 5); colon: 7.2 nTPM (protected, limit 2); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); hippocampal formation: 5.4 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); smooth muscle: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000147912,FBXO10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.432759,-0.530669,-0.722143
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,12.2,6,11.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 11.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 2); cerebral cortex: 4.5 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 4); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); liver: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 2); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000148019,CEP78,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.6096% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.4595% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.6468% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 71.3592% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.5625% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.9822% (minimum 99%, Baseline (adaptation disabled)); colon: 81.2155% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.2155% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.7407% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.1915% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.7692% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.7692% (minimum 99%, Baseline (adaptation disabled)); liver: 81.2155% (minimum 99%, Baseline (adaptation disabled)); lung: 82.1229% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.0145% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.1915% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.4651% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.7778% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.9711% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.4595% (minimum 97%, Baseline (adaptation disabled)); retina: 62.0253% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.1229% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.1840% (minimum 99%, Baseline (adaptation disabled)); skin: 80.7692% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.1658% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.5625% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.5227% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.7568% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 80.3279% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.1840% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.5843% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,12.2,6,11.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 11.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); liver: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000148019,CEP78,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.382432,-0.259855,-0.443532
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5000% (minimum 90%, Approved); adrenal gland: 84.0000% (minimum 99%, Missing); amygdala: 78.6096% (minimum 99%, Missing); basal ganglia: 79.4595% (minimum 99%, Missing); bone marrow: 54.6468% (minimum 99%, Missing); cerebellum: 71.3592% (minimum 99%, Missing); cerebral cortex: 76.5625% (minimum 99%, Missing); choroid plexus: 86.9822% (minimum 99%, Missing); colon: 81.2155% (minimum 97%, Missing); duodenum: 84.0000% (minimum 98%, Approved); esophagus: 81.2155% (minimum 97%, Missing); heart muscle: 90.7407% (minimum 99%, Missing); hippocampal formation: 78.1915% (minimum 99%, Missing); hypothalamus: 80.7692% (minimum 99%, Missing); kidney: 80.7692% (minimum 99%, Missing); liver: 81.2155% (minimum 99%, Missing); lung: 82.1229% (minimum 99%, Missing); lymph node: 71.0145% (minimum 97%, Missing); midbrain: 78.1915% (minimum 99%, Missing); pancreas: 85.4651% (minimum 99%, Missing); parathyroid gland: 77.7778% (minimum 95%, Approved); pituitary gland: 84.9711% (minimum 99%, Missing); rectum: 79.4595% (minimum 97%, Missing); retina: 62.0253% (minimum 99%, Missing); salivary gland: 82.1229% (minimum 97%, Missing); skeletal muscle: 90.1840% (minimum 99%, Missing); skin: 80.7692% (minimum 95%, Missing); small intestine: 84.0000% (minimum 99%, Missing); smooth muscle: 76.1658% (minimum 98%, Approved); spinal cord: 76.5625% (minimum 99%, Missing); spleen: 75.0000% (minimum 90%, Approved); stomach: 83.5227% (minimum 97%, Missing); thymus: 56.7568% (minimum 95%, Missing); thyroid gland: 80.3279% (minimum 95%, Missing); tongue: 90.1840% (minimum 97%, Missing); urinary bladder: 82.5843% (minimum 97%, Missing)",0,2,partial,12.2,6,11.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 11.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 2); cerebral cortex: 4.5 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 4); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); liver: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 2); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000148019,CEP78,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.382432,-0.259855,-0.443532
True,compatible,,True,True,False,,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000148156,ACTL7B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000148156,ACTL7B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000148156,ACTL7B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.3,2.2,5.2,"thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148200,NR6A1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.5217% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.1039% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.6897% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.7736% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.7355% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.8718% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.4681% (minimum 99%, Baseline (adaptation disabled)); colon: 90.9836% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.8870% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.6897% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.6897% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.6897% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.2773% (minimum 99%, Baseline (adaptation disabled)); liver: 89.5161% (minimum 99%, Baseline (adaptation disabled)); lung: 93.6709% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.5217% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.8000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.5217% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.0678% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.6709% (minimum 97%, Baseline (adaptation disabled)); retina: 88.0952% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.8718% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.4681% (minimum 99%, Baseline (adaptation disabled)); skin: 91.3580% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.8785% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.2301% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.9432% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 81.0219% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.5217% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.9432% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.3,2.2,5.2,"thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148200,NR6A1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.139781,-0.0601639,-0.152264
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.5217% (minimum 99%, Missing); amygdala: 96.1039% (minimum 99%, Missing); basal ganglia: 95.6897% (minimum 99%, Missing); bone marrow: 83.7736% (minimum 99%, Missing); cerebellum: 91.7355% (minimum 99%, Missing); cerebral cortex: 94.8718% (minimum 99%, Missing); choroid plexus: 94.4681% (minimum 99%, Missing); colon: 90.9836% (minimum 97%, Missing); duodenum: 92.8870% (minimum 99%, Missing); esophagus: 92.5000% (minimum 97%, Missing); heart muscle: 95.6897% (minimum 99%, Missing); hippocampal formation: 95.6897% (minimum 99%, Missing); hypothalamus: 95.6897% (minimum 99%, Missing); kidney: 93.2773% (minimum 99%, Missing); liver: 89.5161% (minimum 99%, Missing); lung: 93.6709% (minimum 99%, Missing); midbrain: 96.5217% (minimum 99%, Missing); pancreas: 88.8000% (minimum 99%, Missing); parathyroid gland: 96.5217% (minimum 97%, Missing); pituitary gland: 94.0678% (minimum 99%, Missing); rectum: 93.6709% (minimum 97%, Missing); retina: 88.0952% (minimum 99%, Missing); salivary gland: 94.8718% (minimum 97%, Missing); skeletal muscle: 94.4681% (minimum 99%, Missing); skin: 91.3580% (minimum 95%, Missing); small intestine: 89.8785% (minimum 99%, Missing); smooth muscle: 98.2301% (minimum 99%, Missing); spinal cord: 96.9432% (minimum 99%, Missing); thyroid gland: 81.0219% (minimum 95%, Missing); tongue: 96.5217% (minimum 97%, Missing); urinary bladder: 96.9432% (minimum 97%, Missing)",0,80,unavailable,4.3,2.2,5.2,"thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148200,NR6A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.139781,-0.0601639,-0.152264
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000148215,OR5C1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000148215,OR5C1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000148215,OR5C1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,24.9,0,0,"retina: 24.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000148602,LRIT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.3607% (minimum 99%, Baseline (adaptation disabled)); retina: 19.4175% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,24.9,0,0,"retina: 24.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000148602,LRIT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.795825
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.3607% (minimum 99%, Missing); retina: 19.4175% (minimum 99%, Missing)",0,80,unavailable,24.9,0,0,"retina: 24.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000148602,LRIT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.795825
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,134.8,0.2,0.2,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000148604,RGR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); amygdala: 12.9032% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 10.8108% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 7.1429% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 2.3392% (minimum 99%, Baseline (adaptation disabled)); colon: 88.8889% (minimum 97%, Baseline (adaptation disabled)); esophagus: 88.8889% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.5385% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 30.7692% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 27.5862% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 20.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 0.5900% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.8889% (minimum 97%, Baseline (adaptation disabled)); small intestine: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.8889% (minimum 99%, Baseline (adaptation disabled)); stomach: 80.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,134.8,0.2,0.2,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000148604,RGR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.15,-0.17,-0.9841
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 80.0000% (minimum 95%, Missing); amygdala: 12.9032% (minimum 99%, Missing); basal ganglia: 10.8108% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 7.1429% (minimum 99%, Missing); choroid plexus: 2.3392% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); esophagus: 88.8889% (minimum 97%, Missing); heart muscle: 61.5385% (minimum 99%, Missing); hippocampal formation: 30.7692% (minimum 99%, Missing); hypothalamus: 27.5862% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); midbrain: 20.0000% (minimum 99%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); retina: 0.5900% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); small intestine: 88.8889% (minimum 99%, Missing); spinal cord: 88.8889% (minimum 99%, Missing); stomach: 80.0000% (minimum 97%, Missing)",0,80,unavailable,134.8,0.2,0.2,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000148604,RGR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.15,-0.17,-0.9841
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,2,12.7,1.1,"parathyroid gland: 12.7 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000148680,HTR7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 94.4444% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.7011% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.5056% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.5909% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.5909% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.8586% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8372% (minimum 99%, Baseline (adaptation disabled)); colon: 93.4066% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.4444% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.3913% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.8372% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.4737% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.9524% (minimum 99%, Baseline (adaptation disabled)); liver: 95.5056% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7011% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.4066% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.4444% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.8372% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 40.0943% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.8372% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.4255% (minimum 97%, Baseline (adaptation disabled)); retina: 98.8372% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 90.4255% (minimum 99%, Baseline (adaptation disabled)); skin: 94.4444% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.7347% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.5909% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.5909% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.5417% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.3913% (minimum 97%, Baseline (adaptation disabled)); tongue: 94.4444% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 79.4393% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,2,12.7,1.1,"parathyroid gland: 12.7 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000148680,HTR7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0645833,-0.569057,-0.180476
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.7011% (minimum 99%, Missing); amygdala: 95.5056% (minimum 99%, Missing); basal ganglia: 96.5909% (minimum 99%, Missing); bone marrow: 96.5909% (minimum 98%, Approved); cerebral cortex: 85.8586% (minimum 99%, Missing); choroid plexus: 98.8372% (minimum 99%, Missing); colon: 93.4066% (minimum 97%, Missing); duodenum: 94.4444% (minimum 98%, Approved); esophagus: 92.3913% (minimum 95%, Approved); hippocampal formation: 89.4737% (minimum 99%, Missing); hypothalamus: 80.9524% (minimum 99%, Missing); liver: 95.5056% (minimum 98%, Approved); lung: 97.7011% (minimum 99%, Missing); lymph node: 93.4066% (minimum 97%, Missing); midbrain: 94.4444% (minimum 99%, Missing); pancreas: 98.8372% (minimum 99%, Missing); parathyroid gland: 40.0943% (minimum 97%, Missing); pituitary gland: 98.8372% (minimum 99%, Missing); rectum: 90.4255% (minimum 95%, Approved); retina: 98.8372% (minimum 99%, Missing); skeletal muscle: 90.4255% (minimum 98%, Approved); small intestine: 86.7347% (minimum 98%, Approved); smooth muscle: 96.5909% (minimum 98%, Approved); spinal cord: 96.5909% (minimum 99%, Missing); spleen: 88.5417% (minimum 95%, Missing); stomach: 92.3913% (minimum 97%, Missing); tongue: 94.4444% (minimum 97%, Missing); urinary bladder: 79.4393% (minimum 97%, Missing)",0,3,partial,2,12.7,1.1,"parathyroid gland: 12.7 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000148680,HTR7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0645833,-0.569057,-0.180476
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,10,partial,15.3,7.7,6.2,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); kidney: 6.9 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148814,LRRC27,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.9612% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.6774% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.8084% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.2308% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.3858% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.7703% (minimum 99%, Baseline (adaptation disabled)); colon: 94.2308% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.7105% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.5787% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.9041% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.8645% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.4179% (minimum 99%, Baseline (adaptation disabled)); liver: 96.0784% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0841% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.7105% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.9187% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.0841% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.5172% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.4059% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.7105% (minimum 97%, Baseline (adaptation disabled)); retina: 87.3960% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.8279% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.3510% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.8279% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.7165% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.9633% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.1559% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.0841% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.2208% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.9612% (minimum 97%, Baseline (adaptation disabled))",0,10,partial,15.3,7.7,6.2,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); kidney: 6.9 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); spleen: 5.4 nTPM (manageable, limit 5); colon: 4.5 nTPM (protected, limit 2); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); pancreas: 3.8 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); duodenum: 2.5 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148814,LRRC27,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0277917,-0.0648276,-0.162297
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.9612% (minimum 95%, Enhanced); amygdala: 84.6774% (minimum 99%, Missing); basal ganglia: 83.8084% (minimum 99%, Missing); cerebellum: 94.2308% (minimum 99%, Missing); cerebral cortex: 84.3858% (minimum 99%, Missing); choroid plexus: 82.7703% (minimum 99%, Missing); colon: 94.2308% (minimum 97%, Missing); duodenum: 96.7105% (minimum 99%, Missing); hippocampal formation: 83.9041% (minimum 99%, Missing); hypothalamus: 85.8645% (minimum 99%, Missing); kidney: 91.4179% (minimum 99%, Missing); midbrain: 87.9187% (minimum 99%, Missing); parathyroid gland: 90.5172% (minimum 97%, Missing); pituitary gland: 90.4059% (minimum 99%, Missing); rectum: 96.7105% (minimum 97%, Missing); retina: 87.3960% (minimum 99%, Missing); small intestine: 95.8279% (minimum 99%, Missing); smooth muscle: 94.7165% (minimum 99%, Missing); spinal cord: 89.9633% (minimum 99%, Missing); stomach: 95.0841% (minimum 97%, Missing)",0,10,partial,15.3,7.7,6.2,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); kidney: 6.9 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148814,LRRC27,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0145669,-0.0648276,-0.162297
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.5,6.1,4.7,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148832,PAOX,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.6620% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.3611% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.7241% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.7241% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.1695% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.0959% (minimum 99%, Baseline (adaptation disabled)); colon: 91.4089% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.6620% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.3456% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.6619% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.4762% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.0070% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.9632% (minimum 99%, Baseline (adaptation disabled)); liver: 78.0059% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.7241% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.7241% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.6619% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.8649% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.1695% (minimum 99%, Baseline (adaptation disabled)); skin: 90.7850% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.0841% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.8848% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.9281% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.9840% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.7241% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 94.3262% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 90.4762% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7.5,6.1,4.7,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148832,PAOX,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.10016,-0.156544,-0.209941
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.6620% (minimum 95%, Missing); adrenal gland: 92.3611% (minimum 99%, Missing); amygdala: 91.7241% (minimum 99%, Missing); basal ganglia: 91.7241% (minimum 99%, Missing); cerebellum: 90.1695% (minimum 99%, Missing); cerebral cortex: 91.0959% (minimum 99%, Missing); colon: 91.4089% (minimum 97%, Missing); duodenum: 93.6620% (minimum 99%, Missing); esophagus: 81.3456% (minimum 97%, Missing); heart muscle: 94.6619% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 93.0070% (minimum 99%, Missing); kidney: 88.9632% (minimum 99%, Missing); liver: 78.0059% (minimum 99%, Missing); lung: 95.0000% (minimum 99%, Missing); midbrain: 91.7241% (minimum 99%, Missing); pancreas: 91.7241% (minimum 99%, Missing); pituitary gland: 94.6619% (minimum 99%, Missing); salivary gland: 89.8649% (minimum 97%, Missing); skeletal muscle: 90.1695% (minimum 99%, Missing); skin: 90.7850% (minimum 95%, Missing); small intestine: 86.0841% (minimum 99%, Missing); smooth muscle: 98.8848% (minimum 99%, Missing); spinal cord: 86.9281% (minimum 99%, Missing); spleen: 84.9840% (minimum 95%, Missing); stomach: 91.7241% (minimum 97%, Missing); thyroid gland: 94.3262% (minimum 95%, Missing); urinary bladder: 90.4762% (minimum 97%, Missing)",0,80,unavailable,7.5,6.1,4.7,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148832,PAOX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.10016,-0.156544,-0.209941
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,3.1,8.6,7.8,"basal ganglia: 2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148848,ADAM12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.3560% (minimum 95%, Baseline (adaptation disabled)); basal ganglia: 98.4894% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.6779% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 93.8129% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,3.1,8.6,7.8,"urinary bladder: 8.6 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 3.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148848,ADAM12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,-0.00643994,-0.0318705,-0.013221
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.4894% (minimum 99%, Missing)",0,3,partial,3.1,8.6,7.8,"basal ganglia: 2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000148848,ADAM12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Bradley 2020;Gong 2021,0.0393778,0.03,-0.00510574
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,48.3,41,24.1,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 2); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 2); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 2); thyroid gland: 12.8 nTPM (manageable, limit 5); colon: 12.3 nTPM (protected, limit 2); skin: 12.1 nTPM (manageable, limit 5); esophagus: 11.4 nTPM (protected, limit 2); salivary gland: 11.4 nTPM (protected, limit 2); adipose tissue: 11.3 nTPM (manageable, limit 10); bone marrow: 11 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); urinary bladder: 10.5 nTPM (protected, limit 2); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); lymph node: 9.3 nTPM (protected, limit 2); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000148950,IMMP1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.9603% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.7596% (minimum 99%, Baseline (adaptation disabled)); amygdala: 42.2125% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 39.3487% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 39.4022% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 44.8916% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 44.8223% (minimum 99%, Baseline (adaptation disabled)); colon: 70.2179% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.5401% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.7822% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 53.3088% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 46.2520% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 49.4881% (minimum 99%, Baseline (adaptation disabled)); kidney: 52.3466% (minimum 99%, Baseline (adaptation disabled)); liver: 61.5711% (minimum 99%, Baseline (adaptation disabled)); lung: 76.9231% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.7180% (minimum 97%, Baseline (adaptation disabled)); midbrain: 52.5362% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.4444% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.7706% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.0928% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.9354% (minimum 97%, Baseline (adaptation disabled)); retina: 44.2748% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.7822% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 37.5162% (minimum 99%, Baseline (adaptation disabled)); skin: 70.5596% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.9162% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.7913% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.2016% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.2323% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.3616% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.6139% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 69.3780% (minimum 95%, Baseline (adaptation disabled)); tongue: 41.4286% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.4177% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,48.3,41,24.1,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 2); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 2); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 2); thyroid gland: 12.8 nTPM (manageable, limit 5); colon: 12.3 nTPM (protected, limit 2); skin: 12.1 nTPM (manageable, limit 5); esophagus: 11.4 nTPM (protected, limit 2); salivary gland: 11.4 nTPM (protected, limit 2); adipose tissue: 11.3 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); urinary bladder: 10.5 nTPM (protected, limit 2); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); lymph node: 9.3 nTPM (protected, limit 2); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000148950,IMMP1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.403861,-0.555714,-0.614838
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.9603% (minimum 90%, Approved); adrenal gland: 65.7596% (minimum 99%, Missing); amygdala: 42.2125% (minimum 99%, Missing); basal ganglia: 39.3487% (minimum 99%, Missing); bone marrow: 72.5000% (minimum 99%, Missing); cerebellum: 39.4022% (minimum 99%, Missing); cerebral cortex: 44.8916% (minimum 99%, Missing); choroid plexus: 44.8223% (minimum 99%, Missing); colon: 70.2179% (minimum 97%, Missing); duodenum: 77.5401% (minimum 99%, Missing); esophagus: 71.7822% (minimum 97%, Missing); heart muscle: 53.3088% (minimum 99%, Missing); hippocampal formation: 46.2520% (minimum 99%, Missing); hypothalamus: 49.4881% (minimum 99%, Missing); kidney: 52.3466% (minimum 99%, Missing); liver: 61.5711% (minimum 99%, Missing); lung: 76.9231% (minimum 99%, Missing); lymph node: 75.7180% (minimum 97%, Missing); midbrain: 52.5362% (minimum 99%, Missing); pancreas: 64.4444% (minimum 99%, Missing); parathyroid gland: 62.7706% (minimum 97%, Missing); pituitary gland: 56.0928% (minimum 99%, Missing); rectum: 74.9354% (minimum 97%, Missing); retina: 44.2748% (minimum 99%, Missing); salivary gland: 71.7822% (minimum 97%, Missing); skeletal muscle: 37.5162% (minimum 99%, Missing); skin: 70.5596% (minimum 95%, Missing); small intestine: 75.9162% (minimum 99%, Missing); smooth muscle: 73.7913% (minimum 99%, Missing); spinal cord: 56.2016% (minimum 99%, Missing); spleen: 73.2323% (minimum 95%, Missing); stomach: 66.3616% (minimum 97%, Missing); thymus: 54.6139% (minimum 95%, Missing); thyroid gland: 69.3780% (minimum 95%, Missing); tongue: 41.4286% (minimum 97%, Missing); urinary bladder: 73.4177% (minimum 97%, Missing)",0,5,partial,48.3,41,24.1,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 2); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 2); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 2); thyroid gland: 12.8 nTPM (manageable, limit 5); colon: 12.3 nTPM (protected, limit 2); skin: 12.1 nTPM (manageable, limit 5); esophagus: 11.4 nTPM (protected, limit 2); salivary gland: 11.4 nTPM (protected, limit 2); adipose tissue: 11.3 nTPM (manageable, limit 10); bone marrow: 11 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); urinary bladder: 10.5 nTPM (protected, limit 2); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 2); lymph node: 9.3 nTPM (protected, limit 2); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000148950,IMMP1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.403861,-0.555714,-0.614838
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.2,2.4,3.3,"retina: 5.2 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149050,ZNF214,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.0465% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.7234% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.0833% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.5490% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.8113% (minimum 99%, Baseline (adaptation disabled)); colon: 75.5102% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.0952% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.0952% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.2222% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.7234% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.0833% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 75.5102% (minimum 99%, Baseline (adaptation disabled)); lung: 75.5102% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.8718% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.0465% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.7234% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.6557% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 74.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.7234% (minimum 97%, Baseline (adaptation disabled)); retina: 41.5730% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.4348% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 92.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.0465% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.5185% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.0909% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.8718% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.0465% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.8718% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.8571% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.2439% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.5490% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.2,2.4,3.3,"retina: 5.2 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149050,ZNF214,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.421429,-0.363443,-0.57427
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.0465% (minimum 95%, Missing); adrenal gland: 78.7234% (minimum 99%, Missing); amygdala: 82.2222% (minimum 99%, Missing); basal ganglia: 74.0000% (minimum 99%, Missing); cerebellum: 77.0833% (minimum 99%, Missing); cerebral cortex: 72.5490% (minimum 99%, Missing); choroid plexus: 69.8113% (minimum 99%, Missing); colon: 75.5102% (minimum 97%, Missing); duodenum: 88.0952% (minimum 99%, Missing); esophagus: 88.0952% (minimum 97%, Missing); heart muscle: 82.2222% (minimum 99%, Missing); hippocampal formation: 78.7234% (minimum 99%, Missing); hypothalamus: 77.0833% (minimum 99%, Missing); kidney: 61.6667% (minimum 99%, Missing); liver: 75.5102% (minimum 99%, Missing); lung: 75.5102% (minimum 99%, Missing); lymph node: 94.8718% (minimum 97%, Missing); midbrain: 86.0465% (minimum 99%, Missing); pancreas: 78.7234% (minimum 99%, Missing); parathyroid gland: 60.6557% (minimum 97%, Missing); pituitary gland: 74.0000% (minimum 99%, Missing); rectum: 78.7234% (minimum 97%, Missing); retina: 41.5730% (minimum 99%, Missing); salivary gland: 80.4348% (minimum 97%, Missing); skeletal muscle: 92.5000% (minimum 99%, Missing); skin: 92.5000% (minimum 95%, Missing); small intestine: 86.0465% (minimum 99%, Missing); smooth muscle: 68.5185% (minimum 99%, Missing); spinal cord: 84.0909% (minimum 99%, Missing); spleen: 94.8718% (minimum 95%, Missing); stomach: 86.0465% (minimum 97%, Missing); thymus: 94.8718% (minimum 95%, Missing); thyroid gland: 52.8571% (minimum 95%, Missing); tongue: 90.2439% (minimum 97%, Missing); urinary bladder: 72.5490% (minimum 97%, Missing)",0,80,unavailable,5.2,2.4,3.3,"retina: 5.2 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149050,ZNF214,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.421429,-0.363443,-0.57427
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,2.2,3.3,1.6,"lymph node: 3.3 nTPM (protected, limit 2); pancreas: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000149054,ZNF215,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.9474% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.9474% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.2353% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.1818% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.7500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.7500% (minimum 99%, Baseline (adaptation disabled)); colon: 42.8571% (minimum 97%, Baseline (adaptation disabled)); duodenum: 41.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.2174% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 78.9474% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.2353% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.4286% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 31.2500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.7500% (minimum 99%, Baseline (adaptation disabled)); pancreas: 40.5405% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 88.2353% (minimum 99%, Baseline (adaptation disabled)); rectum: 37.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 78.9474% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.5714% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.2353% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 44.1176% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.7500% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.3871% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.1818% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.6923% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.2174% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.7500% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,2.2,3.3,1.6,"lymph node: 3.3 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000149054,ZNF215,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.466129,-0.6575,-0.584595
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 78.9474% (minimum 95%, Enhanced); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 88.2353% (minimum 99%, Missing); bone marrow: 68.1818% (minimum 99%, Missing); cerebellum: 93.7500% (minimum 95%, Enhanced); cerebral cortex: 75.0000% (minimum 95%, Enhanced); choroid plexus: 93.7500% (minimum 99%, Missing); colon: 42.8571% (minimum 80%, Enhanced); duodenum: 41.6667% (minimum 95%, Enhanced); esophagus: 65.2174% (minimum 80%, Enhanced); heart muscle: 78.9474% (minimum 99%, Missing); hippocampal formation: 88.2353% (minimum 99%, Missing); hypothalamus: 71.4286% (minimum 99%, Missing); kidney: 60.0000% (minimum 95%, Enhanced); liver: 83.3333% (minimum 95%, Enhanced); lung: 75.0000% (minimum 99%, Missing); lymph node: 31.2500% (minimum 97%, Missing); midbrain: 93.7500% (minimum 99%, Missing); pancreas: 40.5405% (minimum 99%, Missing); pituitary gland: 88.2353% (minimum 99%, Missing); rectum: 37.5000% (minimum 80%, Enhanced); retina: 78.9474% (minimum 99%, Missing); salivary gland: 53.5714% (minimum 80%, Enhanced); skeletal muscle: 88.2353% (minimum 95%, Enhanced); skin: 75.0000% (minimum 95%, Missing); small intestine: 44.1176% (minimum 95%, Enhanced); smooth muscle: 75.0000% (minimum 99%, Missing); spinal cord: 93.7500% (minimum 99%, Missing); spleen: 48.3871% (minimum 95%, Missing); stomach: 68.1818% (minimum 80%, Enhanced); thymus: 57.6923% (minimum 95%, Missing); thyroid gland: 65.2174% (minimum 95%, Missing); tongue: 93.7500% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 80%, Enhanced)",0,2,partial,2.2,3.3,1.6,"lymph node: 3.3 nTPM (protected, limit 2); pancreas: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000149054,ZNF215,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.466129,-0.6575,-0.584595
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,30.7,25,21.2,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 2); lymph node: 23.8 nTPM (protected, limit 2); retina: 22.7 nTPM (vital, limit 1); thymus: 21.2 nTPM (manageable, limit 5); thyroid gland: 21.1 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); spleen: 16.8 nTPM (manageable, limit 5); midbrain: 14.2 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); kidney: 10.1 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 2); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); pancreas: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149212,SESN3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.7798% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.8493% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.5047% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.6313% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.0163% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.7658% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.7188% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.3881% (minimum 99%, Baseline (adaptation disabled)); colon: 91.0714% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.9038% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.7079% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.5171% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.5000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.6034% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.7432% (minimum 99%, Baseline (adaptation disabled)); liver: 88.4858% (minimum 99%, Baseline (adaptation disabled)); lung: 86.4407% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.2128% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.8009% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.9239% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.1739% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.7313% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.9038% (minimum 97%, Baseline (adaptation disabled)); retina: 71.1929% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.3881% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 84.3609% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.2581% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.3077% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.1376% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.9547% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.1182% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.5744% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 72.6684% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.5407% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.8565% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,30.7,25,21.2,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 2); lymph node: 23.8 nTPM (protected, limit 2); retina: 22.7 nTPM (vital, limit 1); thymus: 21.2 nTPM (manageable, limit 5); thyroid gland: 21.1 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); spleen: 16.8 nTPM (manageable, limit 5); midbrain: 14.2 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); kidney: 10.1 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 2); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); pancreas: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149212,SESN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.224256,-0.278261,-0.343687
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.7798% (minimum 95%, Missing); adrenal gland: 76.8493% (minimum 99%, Missing); amygdala: 75.5047% (minimum 99%, Missing); basal ganglia: 64.6313% (minimum 99%, Missing); bone marrow: 76.0163% (minimum 99%, Missing); cerebellum: 88.7658% (minimum 99%, Missing); cerebral cortex: 73.7188% (minimum 99%, Missing); choroid plexus: 85.3881% (minimum 99%, Missing); colon: 91.0714% (minimum 97%, Missing); duodenum: 89.9038% (minimum 99%, Missing); esophagus: 86.7079% (minimum 97%, Missing); heart muscle: 91.5171% (minimum 99%, Missing); hippocampal formation: 82.5000% (minimum 99%, Missing); hypothalamus: 80.6034% (minimum 99%, Missing); kidney: 84.7432% (minimum 99%, Missing); liver: 88.4858% (minimum 99%, Missing); lung: 86.4407% (minimum 99%, Missing); lymph node: 70.2128% (minimum 97%, Missing); midbrain: 79.8009% (minimum 99%, Missing); pancreas: 94.9239% (minimum 99%, Missing); parathyroid gland: 69.1739% (minimum 97%, Missing); pituitary gland: 83.7313% (minimum 99%, Missing); rectum: 89.9038% (minimum 97%, Missing); retina: 71.1929% (minimum 99%, Missing); salivary gland: 85.3881% (minimum 97%, Missing); skeletal muscle: 91.6667% (minimum 99%, Missing); skin: 84.3609% (minimum 95%, Missing); small intestine: 82.2581% (minimum 99%, Missing); smooth muscle: 86.3077% (minimum 99%, Missing); spinal cord: 82.1376% (minimum 99%, Missing); spleen: 76.9547% (minimum 95%, Missing); stomach: 92.1182% (minimum 97%, Missing); thymus: 72.5744% (minimum 95%, Missing); thyroid gland: 72.6684% (minimum 95%, Missing); tongue: 81.5407% (minimum 97%, Missing); urinary bladder: 83.8565% (minimum 97%, Missing)",0,80,unavailable,30.7,25,21.2,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 2); lymph node: 23.8 nTPM (protected, limit 2); retina: 22.7 nTPM (vital, limit 1); thymus: 21.2 nTPM (manageable, limit 5); thyroid gland: 21.1 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); spleen: 16.8 nTPM (manageable, limit 5); midbrain: 14.2 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 2); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); kidney: 10.1 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 2); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); pancreas: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149212,SESN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.224256,-0.278261,-0.343687
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,10.4,1.1,1.1,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000149243,KLHL35,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7368% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.8367% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.4286% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 46.3918% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.2857% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.7742% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.7447% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.8367% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.8661% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.8108% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.7742% (minimum 99%, Baseline (adaptation disabled)); lung: 92.7835% (minimum 99%, Baseline (adaptation disabled)); midbrain: 77.5862% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.1121% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.9091% (minimum 99%, Baseline (adaptation disabled)); retina: 93.7500% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.7835% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.7447% (minimum 99%, Baseline (adaptation disabled)); skin: 91.8367% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.9011% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.9011% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.6934% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.1089% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.1089% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.7500% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.7742% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,10.4,1.1,1.1,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000149243,KLHL35,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0589109,-0.0789109,-0.526082
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.8367% (minimum 95%, Enhanced); amygdala: 71.4286% (minimum 99%, Missing); basal ganglia: 46.3918% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 95%, Enhanced); cerebral cortex: 64.2857% (minimum 95%, Enhanced); choroid plexus: 96.7742% (minimum 99%, Missing); heart muscle: 91.8367% (minimum 95%, Enhanced); hippocampal formation: 70.8661% (minimum 99%, Missing); hypothalamus: 60.8108% (minimum 99%, Missing); lung: 92.7835% (minimum 95%, Enhanced); midbrain: 77.5862% (minimum 99%, Missing); pancreas: 84.1121% (minimum 95%, Enhanced); pituitary gland: 90.9091% (minimum 99%, Missing); retina: 93.7500% (minimum 99%, Missing); spinal cord: 65.6934% (minimum 99%, Missing)",0,3,partial,10.4,1.1,1.1,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000149243,KLHL35,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.039011,0.00826087,-0.526082
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,5.2,3.2,3.6,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000149346,SLX4IP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.4098% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.7692% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.7692% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 63.0137% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.0159% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.1935% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.7692% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 69.6970% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.8750% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.8889% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.9661% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 69.6970% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.7887% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.0137% (minimum 99%, Baseline (adaptation disabled)); liver: 59.7403% (minimum 99%, Baseline (adaptation disabled)); lung: 76.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.6567% (minimum 97%, Baseline (adaptation disabled)); midbrain: 67.6471% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.1622% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.9744% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.6471% (minimum 97%, Baseline (adaptation disabled)); retina: 46.9388% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.8750% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 53.4884% (minimum 99%, Baseline (adaptation disabled)); skin: 56.0976% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.6970% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.1429% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.8889% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.7887% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.6471% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.7887% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 63.8889% (minimum 95%, Baseline (adaptation disabled)); tongue: 85.1852% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 74.1935% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,5.2,3.2,3.6,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000149346,SLX4IP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.389024,-0.380256,-0.520612
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.4098% (minimum 90%, Approved); adrenal gland: 70.7692% (minimum 99%, Missing); amygdala: 70.7692% (minimum 99%, Missing); basal ganglia: 63.0137% (minimum 99%, Missing); bone marrow: 73.0159% (minimum 99%, Missing); cerebellum: 74.1935% (minimum 99%, Missing); cerebral cortex: 70.7692% (minimum 99%, Missing); choroid plexus: 76.6667% (minimum 99%, Missing); colon: 69.6970% (minimum 97%, Missing); duodenum: 71.8750% (minimum 99%, Missing); esophagus: 63.8889% (minimum 97%, Missing); heart muscle: 77.9661% (minimum 99%, Missing); hippocampal formation: 69.6970% (minimum 99%, Missing); hypothalamus: 64.7887% (minimum 99%, Missing); kidney: 63.0137% (minimum 99%, Missing); liver: 59.7403% (minimum 99%, Missing); lung: 76.6667% (minimum 99%, Missing); lymph node: 68.6567% (minimum 97%, Missing); midbrain: 67.6471% (minimum 99%, Missing); pancreas: 62.1622% (minimum 99%, Missing); parathyroid gland: 58.9744% (minimum 97%, Missing); pituitary gland: 50.0000% (minimum 99%, Missing); rectum: 67.6471% (minimum 97%, Missing); retina: 46.9388% (minimum 99%, Missing); salivary gland: 71.8750% (minimum 97%, Missing); skeletal muscle: 53.4884% (minimum 99%, Missing); skin: 56.0976% (minimum 95%, Missing); small intestine: 69.6970% (minimum 99%, Missing); smooth muscle: 82.1429% (minimum 99%, Missing); spinal cord: 63.8889% (minimum 99%, Missing); spleen: 64.7887% (minimum 90%, Approved); stomach: 67.6471% (minimum 97%, Missing); thymus: 64.7887% (minimum 95%, Missing); thyroid gland: 63.8889% (minimum 95%, Missing); tongue: 85.1852% (minimum 97%, Missing); urinary bladder: 74.1935% (minimum 97%, Missing)",0,1,partial,5.2,3.2,3.6,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000149346,SLX4IP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.389024,-0.380256,-0.520612
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / squamous epithelial cells,ENSG00000149507,OOSP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / squamous epithelial cells,ENSG00000149507,OOSP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / squamous epithelial cells,ENSG00000149507,OOSP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.1,3.8,2.7,"salivary gland: 3.8 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149548,CCDC15,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.5780% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.1429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.2264% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.1429% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.9268% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0769% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.2264% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.1429% (minimum 99%, Baseline (adaptation disabled)); colon: 93.5780% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.5780% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.7273% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.0769% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.1429% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.1429% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.4444% (minimum 99%, Baseline (adaptation disabled)); liver: 88.6957% (minimum 99%, Baseline (adaptation disabled)); lung: 93.5780% (minimum 99%, Baseline (adaptation disabled)); lymph node: 89.4737% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.2264% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.7273% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.4444% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.3271% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.7273% (minimum 97%, Baseline (adaptation disabled)); retina: 86.4407% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.8571% (minimum 97%, Baseline (adaptation disabled)); skin: 82.9268% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.4444% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.4444% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.3271% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.7273% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.4444% (minimum 97%, Baseline (adaptation disabled)); thymus: 79.0698% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.4444% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.3271% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.1,3.8,2.7,"salivary gland: 3.8 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149548,CCDC15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.159302,-0.241429,-0.160732
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.5780% (minimum 95%, Missing); adrenal gland: 97.1429% (minimum 99%, Missing); amygdala: 96.2264% (minimum 99%, Missing); basal ganglia: 97.1429% (minimum 99%, Missing); bone marrow: 82.9268% (minimum 99%, Missing); cerebellum: 98.0769% (minimum 99%, Missing); cerebral cortex: 96.2264% (minimum 99%, Missing); choroid plexus: 97.1429% (minimum 99%, Missing); colon: 93.5780% (minimum 97%, Missing); duodenum: 93.5780% (minimum 99%, Missing); esophagus: 92.7273% (minimum 97%, Missing); heart muscle: 98.0769% (minimum 99%, Missing); hippocampal formation: 97.1429% (minimum 99%, Missing); hypothalamus: 97.1429% (minimum 99%, Missing); kidney: 94.4444% (minimum 99%, Missing); liver: 88.6957% (minimum 99%, Missing); lung: 93.5780% (minimum 99%, Missing); lymph node: 89.4737% (minimum 97%, Missing); midbrain: 96.2264% (minimum 99%, Missing); pancreas: 92.7273% (minimum 99%, Missing); parathyroid gland: 94.4444% (minimum 97%, Missing); pituitary gland: 95.3271% (minimum 99%, Missing); rectum: 92.7273% (minimum 97%, Missing); retina: 86.4407% (minimum 99%, Missing); salivary gland: 72.8571% (minimum 97%, Missing); skin: 82.9268% (minimum 95%, Missing); small intestine: 94.4444% (minimum 99%, Missing); smooth muscle: 94.4444% (minimum 99%, Missing); spinal cord: 95.3271% (minimum 99%, Missing); spleen: 92.7273% (minimum 95%, Missing); stomach: 94.4444% (minimum 97%, Missing); thymus: 79.0698% (minimum 95%, Missing); thyroid gland: 94.4444% (minimum 95%, Missing); urinary bladder: 95.3271% (minimum 97%, Missing)",0,80,unavailable,2.1,3.8,2.7,"salivary gland: 3.8 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149548,CCDC15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.159302,-0.241429,-0.160732
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,26,14.7,20.4,"bone marrow: 26 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 2); parathyroid gland: 12.8 nTPM (protected, limit 2); rectum: 8.6 nTPM (protected, limit 2); colon: 8 nTPM (protected, limit 2); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149554,CHEK1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.5338% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.0784% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.0784% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.4545% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 53.0686% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.3934% (minimum 99%, Baseline (adaptation disabled)); colon: 78.6096% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.0297% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.0784% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.0784% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.7445% (minimum 99%, Baseline (adaptation disabled)); liver: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 95.7655% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.8387% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.9297% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.6682% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.8387% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.3684% (minimum 97%, Baseline (adaptation disabled)); retina: 97.0297% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.1456% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 89.3617% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.1090% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.9083% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.4545% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.3043% (minimum 97%, Baseline (adaptation disabled)); thymus: 59.0361% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.0784% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.9083% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,26,14.7,20.4,"bone marrow: 26 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 2); parathyroid gland: 12.8 nTPM (protected, limit 2); rectum: 8.6 nTPM (protected, limit 2); colon: 8 nTPM (protected, limit 2); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149554,CHEK1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.359639,-0.303333,-0.459314
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.5338% (minimum 95%, Missing); adrenal gland: 96.0784% (minimum 99%, Missing); amygdala: 96.0784% (minimum 99%, Missing); basal ganglia: 95.4545% (minimum 99%, Missing); bone marrow: 53.0686% (minimum 99%, Missing); cerebellum: 98.0000% (minimum 99%, Missing); cerebral cortex: 96.3934% (minimum 99%, Missing); colon: 78.6096% (minimum 97%, Missing); duodenum: 81.6667% (minimum 99%, Missing); esophagus: 87.5000% (minimum 97%, Missing); heart muscle: 97.0297% (minimum 99%, Missing); hippocampal formation: 96.0784% (minimum 99%, Missing); hypothalamus: 96.0784% (minimum 99%, Missing); kidney: 92.7445% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); lung: 95.7655% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 94.8387% (minimum 99%, Missing); pancreas: 93.9297% (minimum 99%, Missing); parathyroid gland: 69.6682% (minimum 97%, Missing); pituitary gland: 94.8387% (minimum 99%, Missing); rectum: 77.3684% (minimum 97%, Missing); retina: 97.0297% (minimum 99%, Missing); salivary gland: 95.1456% (minimum 97%, Missing); skeletal muscle: 98.0000% (minimum 99%, Missing); skin: 89.3617% (minimum 95%, Missing); small intestine: 80.1090% (minimum 99%, Missing); smooth muscle: 89.9083% (minimum 99%, Missing); spinal cord: 95.4545% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Missing); stomach: 91.3043% (minimum 97%, Missing); thymus: 59.0361% (minimum 95%, Missing); tongue: 96.0784% (minimum 97%, Missing); urinary bladder: 89.9083% (minimum 97%, Missing)",0,80,unavailable,26,14.7,20.4,"bone marrow: 26 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 2); parathyroid gland: 12.8 nTPM (protected, limit 2); rectum: 8.6 nTPM (protected, limit 2); colon: 8 nTPM (protected, limit 2); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149554,CHEK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.359639,-0.303333,-0.459314
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000149609,C20orf144,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000149609,C20orf144,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000149609,C20orf144,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,22.9,16.1,5.6,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 2); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 2); salivary gland: 4 nTPM (protected, limit 2); lymph node: 4 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); urinary bladder: 2.7 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000149646,CNBD2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.3043% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.4237% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.3014% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.8485% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 74.3363% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.8966% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.7468% (minimum 99%, Baseline (adaptation disabled)); colon: 86.0068% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.1972% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.3617% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.8966% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.5979% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.1351% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.0642% (minimum 99%, Baseline (adaptation disabled)); liver: 82.3529% (minimum 99%, Baseline (adaptation disabled)); lung: 91.6364% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.3014% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.4237% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.7500% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.0847% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.3226% (minimum 97%, Baseline (adaptation disabled)); retina: 62.2222% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 86.3014% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 52.3909% (minimum 99%, Baseline (adaptation disabled)); skin: 81.8182% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.8485% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.4211% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.8182% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.1972% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.7143% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.8485% (minimum 95%, Baseline (adaptation disabled)); tongue: 61.0169% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.3226% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,22.9,16.1,5.6,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 2); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 2); salivary gland: 4 nTPM (protected, limit 2); lymph node: 4 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); urinary bladder: 2.7 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000149646,CNBD2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.131818,-0.359831,-0.466091
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.3043% (minimum 95%, Missing); adrenal gland: 85.4237% (minimum 99%, Missing); amygdala: 86.3014% (minimum 99%, Missing); basal ganglia: 84.8485% (minimum 99%, Missing); bone marrow: 74.3363% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); cerebral cortex: 86.8966% (minimum 99%, Missing); choroid plexus: 79.7468% (minimum 99%, Missing); colon: 86.0068% (minimum 97%, Missing); duodenum: 87.1972% (minimum 99%, Missing); esophagus: 89.3617% (minimum 97%, Missing); heart muscle: 86.8966% (minimum 99%, Missing); hippocampal formation: 86.5979% (minimum 99%, Missing); hypothalamus: 85.1351% (minimum 99%, Missing); kidney: 77.0642% (minimum 99%, Missing); liver: 82.3529% (minimum 99%, Missing); lung: 91.6364% (minimum 99%, Missing); lymph node: 86.3014% (minimum 97%, Missing); midbrain: 85.4237% (minimum 99%, Missing); pancreas: 78.7500% (minimum 99%, Missing); parathyroid gland: 82.0847% (minimum 97%, Missing); pituitary gland: 84.0000% (minimum 99%, Missing); rectum: 90.3226% (minimum 97%, Missing); retina: 62.2222% (minimum 99%, Missing); salivary gland: 86.3014% (minimum 97%, Missing); skeletal muscle: 52.3909% (minimum 99%, Missing); skin: 81.8182% (minimum 95%, Missing); small intestine: 84.8485% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spinal cord: 88.4211% (minimum 99%, Missing); spleen: 81.8182% (minimum 95%, Missing); stomach: 87.1972% (minimum 97%, Missing); thymus: 85.7143% (minimum 95%, Missing); thyroid gland: 84.8485% (minimum 95%, Missing); tongue: 61.0169% (minimum 97%, Missing); urinary bladder: 90.3226% (minimum 97%, Missing)",0,6,partial,22.9,16.1,5.6,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 2); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 2); salivary gland: 4 nTPM (protected, limit 2); lymph node: 4 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); rectum: 2.7 nTPM (protected, limit 2); urinary bladder: 2.7 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000149646,CNBD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.131818,-0.359831,-0.466091
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,False,,0,2,partial,1,0,0,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland / glandular cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / non-germinal center cells,ENSG00000149651,SPINT4,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0,2,partial,1,0,0,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland / glandular cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / non-germinal center cells,ENSG00000149651,SPINT4,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00633834
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0,2,partial,1,0,0,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland / glandular cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / non-germinal center cells,ENSG00000149651,SPINT4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00633834
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,13.8,4.9,5.2,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.1 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); basal ganglia: 3.9 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); midbrain: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); urinary bladder: 3.6 nTPM (protected, limit 2); spinal cord: 3.5 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149679,CABLES2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.9231% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.2387% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.7907% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.5630% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.0576% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.6364% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.8351% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.4985% (minimum 99%, Baseline (adaptation disabled)); colon: 87.7907% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.5152% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.6907% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.7525% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.0466% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.5524% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.3547% (minimum 99%, Baseline (adaptation disabled)); liver: 88.5630% (minimum 99%, Baseline (adaptation disabled)); lung: 91.5152% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.0399% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.0855% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.6907% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.0855% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.1226% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.6907% (minimum 97%, Baseline (adaptation disabled)); retina: 84.5938% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.4192% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.3575% (minimum 99%, Baseline (adaptation disabled)); skin: 87.7907% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.5362% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.4192% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.6142% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.0466% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.8235% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.3107% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.7955% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.5630% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.3491% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,13.8,4.9,5.2,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.1 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); basal ganglia: 3.9 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); midbrain: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); urinary bladder: 3.6 nTPM (protected, limit 2); spinal cord: 3.5 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149679,CABLES2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0968927,-0.109601,-0.303636
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.9231% (minimum 95%, Missing); adrenal gland: 91.2387% (minimum 99%, Missing); amygdala: 87.7907% (minimum 99%, Missing); basal ganglia: 88.5630% (minimum 99%, Missing); bone marrow: 79.0576% (minimum 99%, Missing); cerebellum: 68.6364% (minimum 99%, Missing); cerebral cortex: 77.8351% (minimum 99%, Missing); choroid plexus: 93.4985% (minimum 99%, Missing); colon: 87.7907% (minimum 97%, Missing); duodenum: 91.5152% (minimum 99%, Missing); esophagus: 90.6907% (minimum 97%, Missing); heart muscle: 74.7525% (minimum 99%, Missing); hippocampal formation: 88.0466% (minimum 99%, Missing); hypothalamus: 85.5524% (minimum 99%, Missing); kidney: 92.3547% (minimum 99%, Missing); liver: 88.5630% (minimum 99%, Missing); lung: 91.5152% (minimum 99%, Missing); lymph node: 86.0399% (minimum 97%, Missing); midbrain: 89.0855% (minimum 99%, Missing); pancreas: 90.6907% (minimum 99%, Missing); parathyroid gland: 89.0855% (minimum 97%, Missing); pituitary gland: 84.1226% (minimum 99%, Missing); rectum: 90.6907% (minimum 97%, Missing); retina: 84.5938% (minimum 99%, Missing); salivary gland: 90.4192% (minimum 97%, Missing); skeletal muscle: 84.3575% (minimum 99%, Missing); skin: 87.7907% (minimum 95%, Missing); small intestine: 87.5362% (minimum 99%, Missing); smooth muscle: 90.4192% (minimum 99%, Missing); spinal cord: 89.6142% (minimum 99%, Missing); spleen: 88.0466% (minimum 95%, Missing); stomach: 88.8235% (minimum 97%, Missing); thymus: 85.3107% (minimum 95%, Missing); thyroid gland: 85.7955% (minimum 95%, Missing); tongue: 88.5630% (minimum 97%, Missing); urinary bladder: 89.3491% (minimum 97%, Missing)",0,80,unavailable,13.8,4.9,5.2,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.1 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 2); basal ganglia: 3.9 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); midbrain: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); urinary bladder: 3.6 nTPM (protected, limit 2); spinal cord: 3.5 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149679,CABLES2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0968927,-0.109601,-0.303636
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,85.2,1.6,1.1,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149926,TLCD3B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.1696% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.6171% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.3767% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.8361% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.4629% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.8131% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8361% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.8477% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.6346% (minimum 99%, Baseline (adaptation disabled)); midbrain: 86.5760% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 82.9805% (minimum 99%, Baseline (adaptation disabled)); retina: 60.7633% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 90.1770% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.2265% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,85.2,1.6,1.1,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149926,TLCD3B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0393204,0.0145411,-0.445371
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.1696% (minimum 99%, Missing); amygdala: 80.6171% (minimum 99%, Missing); basal ganglia: 82.3767% (minimum 99%, Missing); bone marrow: 98.8361% (minimum 99%, Missing); cerebellum: 54.4629% (minimum 99%, Missing); cerebral cortex: 70.8131% (minimum 99%, Missing); choroid plexus: 98.8361% (minimum 99%, Missing); hippocampal formation: 76.8477% (minimum 99%, Missing); hypothalamus: 84.6346% (minimum 99%, Missing); midbrain: 86.5760% (minimum 99%, Missing); pituitary gland: 82.9805% (minimum 99%, Missing); retina: 60.7633% (minimum 99%, Missing); skeletal muscle: 90.1770% (minimum 99%, Missing); spinal cord: 91.2265% (minimum 99%, Missing)",0,80,unavailable,85.2,1.6,1.1,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000149926,TLCD3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0393204,0.0145411,-0.445371
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,4.8,2.3,0.6,"bone marrow: 4.8 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000149948,HMGA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.2439% (minimum 95%, Baseline (adaptation disabled)); basal ganglia: 97.3684% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 43.5294% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.3684% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.3684% (minimum 99%, Baseline (adaptation disabled)); colon: 64.9123% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.3684% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.8718% (minimum 99%, Baseline (adaptation disabled)); liver: 94.8718% (minimum 99%, Baseline (adaptation disabled)); lung: 97.3684% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.4348% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.2439% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 88.0952% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 69.8113% (minimum 99%, Baseline (adaptation disabled)); skin: 90.2439% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.7234% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.3684% (minimum 99%, Baseline (adaptation disabled)); stomach: 77.0833% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.8718% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.0465% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.8718% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,4.8,2.3,0.6,"bone marrow: 4.8 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000149948,HMGA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0895349,-0.353333,-0.554706
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 97.3684% (minimum 99%, Missing); bone marrow: 43.5294% (minimum 99%, Missing); cerebral cortex: 97.3684% (minimum 99%, Missing); choroid plexus: 97.3684% (minimum 99%, Missing); colon: 64.9123% (minimum 97%, Missing); duodenum: 74.0000% (minimum 99%, Missing); esophagus: 92.5000% (minimum 97%, Missing); heart muscle: 97.3684% (minimum 99%, Missing); kidney: 94.8718% (minimum 99%, Missing); liver: 94.8718% (minimum 99%, Missing); lung: 97.3684% (minimum 99%, Missing); pancreas: 80.4348% (minimum 99%, Missing); pituitary gland: 90.2439% (minimum 99%, Missing); rectum: 61.6667% (minimum 97%, Missing); retina: 88.0952% (minimum 99%, Missing); skeletal muscle: 69.8113% (minimum 99%, Missing); skin: 90.2439% (minimum 95%, Missing); small intestine: 78.7234% (minimum 99%, Missing); smooth muscle: 97.3684% (minimum 99%, Missing); stomach: 77.0833% (minimum 97%, Missing); thymus: 94.8718% (minimum 95%, Missing); thyroid gland: 86.0465% (minimum 95%, Missing); tongue: 94.8718% (minimum 97%, Missing)",0,4,partial,4.8,2.3,0.6,"bone marrow: 4.8 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000149948,HMGA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0895349,-0.353333,-0.554706
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000150244,TRIM48,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000150244,TRIM48,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000150244,TRIM48,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,59.9,0.5,0.7,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150275,PCDH15,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 14.8148% (minimum 99%, Baseline (adaptation disabled)); amygdala: 32.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 47.7612% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.9697% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 32.6531% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.1176% (minimum 99%, Baseline (adaptation disabled)); colon: 96.9697% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.1176% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.9697% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.4865% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 35.1648% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 38.5542% (minimum 99%, Baseline (adaptation disabled)); kidney: 29.3578% (minimum 99%, Baseline (adaptation disabled)); lung: 57.1429% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8889% (minimum 97%, Baseline (adaptation disabled)); midbrain: 38.5542% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.4865% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 41.0256% (minimum 99%, Baseline (adaptation disabled)); retina: 5.0713% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.9697% (minimum 97%, Baseline (adaptation disabled)); small intestine: 94.1176% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.0513% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.4286% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.8889% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,59.9,0.5,0.7,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150275,PCDH15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.129487,-0.105135,-0.939287
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 14.8148% (minimum 99%, Missing); amygdala: 32.0000% (minimum 99%, Missing); basal ganglia: 47.7612% (minimum 99%, Missing); bone marrow: 96.9697% (minimum 99%, Missing); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 32.6531% (minimum 99%, Missing); choroid plexus: 94.1176% (minimum 99%, Missing); colon: 96.9697% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); esophagus: 96.9697% (minimum 97%, Missing); heart muscle: 86.4865% (minimum 99%, Missing); hippocampal formation: 35.1648% (minimum 99%, Missing); hypothalamus: 38.5542% (minimum 99%, Missing); kidney: 29.3578% (minimum 99%, Missing); lung: 57.1429% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); midbrain: 38.5542% (minimum 99%, Missing); parathyroid gland: 86.4865% (minimum 97%, Missing); pituitary gland: 41.0256% (minimum 99%, Missing); retina: 5.0713% (minimum 99%, Missing); salivary gland: 96.9697% (minimum 97%, Missing); small intestine: 94.1176% (minimum 99%, Missing); spinal cord: 53.3333% (minimum 99%, Missing); spleen: 82.0513% (minimum 95%, Missing); stomach: 91.4286% (minimum 97%, Missing); urinary bladder: 88.8889% (minimum 97%, Missing)",0,80,unavailable,59.9,0.5,0.7,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150275,PCDH15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.129487,-0.105135,-0.939287
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.9,8,5.1,"salivary gland: 8 nTPM (protected, limit 2); small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); thyroid gland: 5.1 nTPM (manageable, limit 5); tongue: 4.9 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); lymph node: 3.8 nTPM (protected, limit 2); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150455,TIRAP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.6330% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.1852% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.3810% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.4706% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.3810% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 71.4286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.8925% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.7255% (minimum 99%, Baseline (adaptation disabled)); colon: 54.1667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 45.7746% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.5221% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.1811% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.2469% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.0337% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.9048% (minimum 99%, Baseline (adaptation disabled)); liver: 49.6183% (minimum 99%, Baseline (adaptation disabled)); lung: 63.1068% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.1068% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.0337% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.5873% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.6183% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 65.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.1667% (minimum 97%, Baseline (adaptation disabled)); retina: 68.4211% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 44.8276% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.0357% (minimum 99%, Baseline (adaptation disabled)); skin: 61.9048% (minimum 95%, Baseline (adaptation disabled)); small intestine: 45.1389% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.0357% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.2500% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.5586% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.1068% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.7083% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.0345% (minimum 95%, Baseline (adaptation disabled)); tongue: 57.0175% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.6330% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7.9,8,5.1,"salivary gland: 8 nTPM (protected, limit 2); small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); thyroid gland: 5.1 nTPM (manageable, limit 5); tongue: 4.9 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); lymph node: 3.8 nTPM (protected, limit 2); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150455,TIRAP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.389655,-0.521724,-0.538611
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.6330% (minimum 95%, Missing); adrenal gland: 60.1852% (minimum 99%, Missing); amygdala: 77.3810% (minimum 99%, Missing); basal ganglia: 76.4706% (minimum 99%, Missing); bone marrow: 77.3810% (minimum 99%, Missing); cerebellum: 71.4286% (minimum 99%, Missing); cerebral cortex: 69.8925% (minimum 99%, Missing); choroid plexus: 63.7255% (minimum 99%, Missing); colon: 54.1667% (minimum 97%, Missing); duodenum: 45.7746% (minimum 99%, Missing); esophagus: 57.5221% (minimum 97%, Missing); heart muscle: 51.1811% (minimum 99%, Missing); hippocampal formation: 80.2469% (minimum 99%, Missing); hypothalamus: 73.0337% (minimum 99%, Missing); kidney: 61.9048% (minimum 99%, Missing); liver: 49.6183% (minimum 99%, Missing); lung: 63.1068% (minimum 99%, Missing); lymph node: 63.1068% (minimum 97%, Missing); midbrain: 73.0337% (minimum 99%, Missing); pancreas: 51.5873% (minimum 99%, Missing); parathyroid gland: 49.6183% (minimum 97%, Missing); pituitary gland: 65.0000% (minimum 99%, Missing); rectum: 54.1667% (minimum 97%, Missing); retina: 68.4211% (minimum 99%, Missing); salivary gland: 44.8276% (minimum 97%, Missing); skeletal muscle: 58.0357% (minimum 99%, Missing); skin: 61.9048% (minimum 95%, Missing); small intestine: 45.1389% (minimum 99%, Missing); smooth muscle: 58.0357% (minimum 99%, Missing); spinal cord: 81.2500% (minimum 99%, Missing); spleen: 58.5586% (minimum 95%, Missing); stomach: 63.1068% (minimum 97%, Missing); thymus: 67.7083% (minimum 95%, Missing); thyroid gland: 56.0345% (minimum 95%, Missing); tongue: 57.0175% (minimum 97%, Missing); urinary bladder: 59.6330% (minimum 97%, Missing)",0,80,unavailable,7.9,8,5.1,"salivary gland: 8 nTPM (protected, limit 2); small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); thyroid gland: 5.1 nTPM (manageable, limit 5); tongue: 4.9 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 2); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); lymph node: 3.8 nTPM (protected, limit 2); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150455,TIRAP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.389655,-0.521724,-0.538611
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,20.5,6.7,8.4,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skin: 8.4 nTPM (manageable, limit 5); skeletal muscle: 7 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); pancreas: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.7 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000150477,KIAA1328,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.0059% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.2892% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.6327% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 45.6274% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.9161% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.2174% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.4157% (minimum 99%, Baseline (adaptation disabled)); colon: 75.9494% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.4286% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.4717% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.5369% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.1918% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.5882% (minimum 99%, Baseline (adaptation disabled)); liver: 73.1707% (minimum 99%, Baseline (adaptation disabled)); lung: 69.3642% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.3642% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.9231% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.9494% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 76.4331% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 81.6327% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.4314% (minimum 97%, Baseline (adaptation disabled)); retina: 36.9231% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.1711% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.1579% (minimum 99%, Baseline (adaptation disabled)); skin: 58.8235% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.5714% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.6196% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.9655% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.3642% (minimum 97%, Baseline (adaptation disabled)); thymus: 78.9474% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.4286% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.4194% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 79.4702% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,20.5,6.7,8.4,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skin: 8.4 nTPM (manageable, limit 5); skeletal muscle: 7 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); pancreas: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.7 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000150477,KIAA1328,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.361765,-0.328289,-0.620769
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.0059% (minimum 90%, Approved); adrenal gland: 72.2892% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 81.6327% (minimum 99%, Missing); bone marrow: 45.6274% (minimum 99%, Missing); cerebellum: 83.9161% (minimum 99%, Missing); cerebral cortex: 65.2174% (minimum 99%, Missing); choroid plexus: 67.4157% (minimum 99%, Missing); colon: 75.9494% (minimum 97%, Missing); duodenum: 71.4286% (minimum 99%, Missing); esophagus: 75.4717% (minimum 97%, Missing); heart muscle: 71.4286% (minimum 99%, Missing); hippocampal formation: 80.5369% (minimum 99%, Missing); hypothalamus: 82.1918% (minimum 99%, Missing); kidney: 70.5882% (minimum 99%, Missing); liver: 73.1707% (minimum 99%, Missing); lung: 69.3642% (minimum 99%, Missing); lymph node: 69.3642% (minimum 97%, Missing); midbrain: 76.9231% (minimum 99%, Missing); pancreas: 75.9494% (minimum 99%, Missing); parathyroid gland: 76.4331% (minimum 97%, Missing); pituitary gland: 81.6327% (minimum 99%, Missing); rectum: 78.4314% (minimum 97%, Missing); retina: 36.9231% (minimum 99%, Missing); salivary gland: 64.1711% (minimum 97%, Missing); skeletal muscle: 63.1579% (minimum 99%, Missing); skin: 58.8235% (minimum 95%, Missing); small intestine: 68.5714% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spinal cord: 73.6196% (minimum 99%, Missing); spleen: 68.9655% (minimum 95%, Missing); stomach: 69.3642% (minimum 97%, Missing); thymus: 78.9474% (minimum 95%, Missing); thyroid gland: 71.4286% (minimum 95%, Missing); tongue: 77.4194% (minimum 97%, Missing); urinary bladder: 79.4702% (minimum 97%, Missing)",0,3,partial,20.5,6.7,8.4,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skin: 8.4 nTPM (manageable, limit 5); skeletal muscle: 7 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); pancreas: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); parathyroid gland: 3.7 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000150477,KIAA1328,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.361765,-0.328289,-0.620769
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,131,51,45.2,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 2); salivary gland: 51 nTPM (protected, limit 2); thyroid gland: 45.2 nTPM (manageable, limit 5); stomach: 43.6 nTPM (protected, limit 2); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 2); rectum: 33.4 nTPM (protected, limit 2); colon: 29.6 nTPM (protected, limit 2); esophagus: 26.2 nTPM (protected, limit 2); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 2); heart muscle: 15.9 nTPM (vital, limit 2); lymph node: 15.8 nTPM (protected, limit 2); urinary bladder: 15.6 nTPM (protected, limit 2); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); spleen: 14.1 nTPM (manageable, limit 5); thymus: 13.9 nTPM (manageable, limit 5); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (manageable, limit 10); skin: 9.6 nTPM (manageable, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000150527,MIA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.6467% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.8719% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.5234% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 62.3377% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.2921% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.8421% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 31.3725% (minimum 99%, Baseline (adaptation disabled)); colon: 56.4706% (minimum 97%, Baseline (adaptation disabled)); duodenum: 33.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.4427% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.7182% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.4865% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.5815% (minimum 99%, Baseline (adaptation disabled)); kidney: 34.2246% (minimum 99%, Baseline (adaptation disabled)); liver: 22.6682% (minimum 99%, Baseline (adaptation disabled)); lung: 72.1805% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.8487% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.6817% (minimum 99%, Baseline (adaptation disabled)); pancreas: 47.9401% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.8609% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.7757% (minimum 99%, Baseline (adaptation disabled)); rectum: 53.4819% (minimum 97%, Baseline (adaptation disabled)); retina: 75.5906% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 42.9530% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 42.1978% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 33.9523% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.3419% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.2105% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.1429% (minimum 95%, Baseline (adaptation disabled)); stomach: 46.8293% (minimum 97%, Baseline (adaptation disabled)); thymus: 73.4226% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 45.9330% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.8662% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.1111% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,131,51,45.2,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 1); salivary gland: 51 nTPM (protected, limit 2); thyroid gland: 45.2 nTPM (manageable, limit 5); stomach: 43.6 nTPM (protected, limit 2); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 2); rectum: 33.4 nTPM (protected, limit 2); colon: 29.6 nTPM (protected, limit 2); esophagus: 26.2 nTPM (protected, limit 2); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 2); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 2); urinary bladder: 15.6 nTPM (protected, limit 2); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); spleen: 14.1 nTPM (manageable, limit 5); thymus: 13.9 nTPM (manageable, limit 5); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000150527,MIA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.49067,-0.54047,-0.763318
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.6467% (minimum 90%, Approved); adrenal gland: 60.0000% (minimum 99%, Missing); amygdala: 87.8719% (minimum 99%, Missing); basal ganglia: 85.5234% (minimum 99%, Missing); bone marrow: 62.3377% (minimum 99%, Missing); cerebellum: 86.2921% (minimum 99%, Missing); cerebral cortex: 80.8421% (minimum 99%, Missing); choroid plexus: 31.3725% (minimum 99%, Missing); colon: 56.4706% (minimum 97%, Missing); duodenum: 33.3333% (minimum 99%, Missing); esophagus: 59.4427% (minimum 97%, Missing); heart muscle: 70.7182% (minimum 98%, Approved); hippocampal formation: 86.4865% (minimum 99%, Missing); hypothalamus: 84.5815% (minimum 99%, Missing); kidney: 34.2246% (minimum 99%, Missing); liver: 22.6682% (minimum 99%, Missing); lung: 72.1805% (minimum 99%, Missing); lymph node: 70.8487% (minimum 97%, Missing); midbrain: 86.6817% (minimum 99%, Missing); pancreas: 47.9401% (minimum 99%, Missing); parathyroid gland: 50.8609% (minimum 97%, Missing); pituitary gland: 71.7757% (minimum 99%, Missing); rectum: 53.4819% (minimum 97%, Missing); retina: 75.5906% (minimum 99%, Missing); salivary gland: 42.9530% (minimum 97%, Missing); skeletal muscle: 42.1978% (minimum 98%, Approved); skin: 80.0000% (minimum 95%, Missing); small intestine: 33.9523% (minimum 99%, Missing); smooth muscle: 76.3419% (minimum 99%, Missing); spinal cord: 84.2105% (minimum 99%, Missing); spleen: 73.1429% (minimum 95%, Missing); stomach: 46.8293% (minimum 97%, Missing); thymus: 73.4226% (minimum 95%, Missing); thyroid gland: 45.9330% (minimum 95%, Missing); tongue: 65.8662% (minimum 97%, Missing); urinary bladder: 71.1111% (minimum 97%, Missing)",0,4,partial,131,51,45.2,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 2); salivary gland: 51 nTPM (protected, limit 2); thyroid gland: 45.2 nTPM (manageable, limit 5); stomach: 43.6 nTPM (protected, limit 2); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 2); rectum: 33.4 nTPM (protected, limit 2); colon: 29.6 nTPM (protected, limit 2); esophagus: 26.2 nTPM (protected, limit 2); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 2); heart muscle: 15.9 nTPM (vital, limit 2); lymph node: 15.8 nTPM (protected, limit 2); urinary bladder: 15.6 nTPM (protected, limit 2); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); spleen: 14.1 nTPM (manageable, limit 5); thymus: 13.9 nTPM (manageable, limit 5); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (manageable, limit 10); skin: 9.6 nTPM (manageable, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000150527,MIA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.49067,-0.54047,-0.763318
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,2.2,0.4,1.6,"retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000150628,SPATA4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.6162% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.4012% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4012% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,2.2,0.4,1.6,"kidney: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000150628,SPATA4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0383212,0.0270545,-0.00598837
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.6162% (minimum 99%, Missing); retina: 98.4012% (minimum 99%, Missing)",0,3,partial,2.2,0.4,1.6,"retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000150628,SPATA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.0270545,-0.00598837
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2,10.6,1.3,"rectum: 10.6 nTPM (protected, limit 2); colon: 7.1 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150667,FSIP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.2222% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.9091% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.1053% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.2222% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.1053% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.7778% (minimum 99%, Baseline (adaptation disabled)); colon: 49.6454% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.5915% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.2222% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.5946% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.6076% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.7436% (minimum 99%, Baseline (adaptation disabled)); liver: 98.5915% (minimum 99%, Baseline (adaptation disabled)); lung: 97.2222% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.8904% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.5915% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.7436% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 39.7727% (minimum 97%, Baseline (adaptation disabled)); retina: 89.7436% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.2222% (minimum 99%, Baseline (adaptation disabled)); skin: 89.7436% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.5915% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.8904% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.2222% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.3373% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.5946% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.8904% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2,10.6,1.3,"rectum: 10.6 nTPM (protected, limit 2); colon: 7.1 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150667,FSIP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.106627,-0.572273,-0.212222
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.2222% (minimum 99%, Missing); amygdala: 93.3333% (minimum 99%, Missing); basal ganglia: 90.9091% (minimum 99%, Missing); bone marrow: 92.1053% (minimum 99%, Missing); cerebellum: 97.2222% (minimum 99%, Missing); cerebral cortex: 92.1053% (minimum 99%, Missing); choroid plexus: 77.7778% (minimum 99%, Missing); colon: 49.6454% (minimum 97%, Missing); duodenum: 98.5915% (minimum 99%, Missing); heart muscle: 97.2222% (minimum 99%, Missing); hippocampal formation: 94.5946% (minimum 99%, Missing); hypothalamus: 88.6076% (minimum 99%, Missing); kidney: 89.7436% (minimum 99%, Missing); liver: 98.5915% (minimum 99%, Missing); lung: 97.2222% (minimum 99%, Missing); midbrain: 95.8904% (minimum 99%, Missing); pancreas: 98.5915% (minimum 99%, Missing); parathyroid gland: 89.7436% (minimum 97%, Missing); pituitary gland: 83.3333% (minimum 99%, Missing); rectum: 39.7727% (minimum 97%, Missing); retina: 89.7436% (minimum 99%, Missing); skeletal muscle: 97.2222% (minimum 99%, Missing); skin: 89.7436% (minimum 95%, Missing); small intestine: 98.5915% (minimum 99%, Missing); smooth muscle: 95.8904% (minimum 99%, Missing); spinal cord: 97.2222% (minimum 99%, Missing); stomach: 93.3333% (minimum 97%, Missing); thymus: 84.3373% (minimum 95%, Missing); thyroid gland: 94.5946% (minimum 95%, Missing); urinary bladder: 95.8904% (minimum 97%, Missing)",0,80,unavailable,2,10.6,1.3,"rectum: 10.6 nTPM (protected, limit 2); colon: 7.1 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150667,FSIP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.106627,-0.572273,-0.212222
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000150676,CCDC83,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000150676,CCDC83,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000150676,CCDC83,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,35.5,24.7,32.5,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); skin: 32.5 nTPM (manageable, limit 5); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (manageable, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 2); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 2); colon: 17.1 nTPM (protected, limit 2); urinary bladder: 15.9 nTPM (protected, limit 2); esophagus: 15.7 nTPM (protected, limit 2); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 4); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 2); spleen: 9.7 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.9 nTPM (vital, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 2); lymph node: 4.5 nTPM (protected, limit 4); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000150760,DOCK1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9361% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.6173% (minimum 99%, Baseline (adaptation disabled)); amygdala: 42.6829% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 44.1441% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.2222% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.8581% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 55.8087% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.6052% (minimum 99%, Baseline (adaptation disabled)); colon: 58.8942% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.9453% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.1361% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 46.0526% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.0303% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.8445% (minimum 99%, Baseline (adaptation disabled)); liver: 72.4852% (minimum 99%, Baseline (adaptation disabled)); lung: 64.8148% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.4828% (minimum 97%, Baseline (adaptation disabled)); midbrain: 40.8333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.1361% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.7967% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 81.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.6438% (minimum 97%, Baseline (adaptation disabled)); retina: 91.7603% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.7530% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.0508% (minimum 99%, Baseline (adaptation disabled)); skin: 42.9825% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.6598% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.9767% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 45.2030% (minimum 99%, Baseline (adaptation disabled)); spleen: 71.6374% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.5080% (minimum 97%, Baseline (adaptation disabled)); thymus: 74.6951% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.7078% (minimum 95%, Baseline (adaptation disabled)); tongue: 70.8092% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.6436% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,35.5,24.7,32.5,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); skin: 32.5 nTPM (manageable, limit 5); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (manageable, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 2); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 2); colon: 17.1 nTPM (protected, limit 2); urinary bladder: 15.9 nTPM (protected, limit 2); esophagus: 15.7 nTPM (protected, limit 2); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 2); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 2); spleen: 9.7 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.9 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000150760,DOCK1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.520175,-0.472033,-0.581667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9361% (minimum 95%, Missing); adrenal gland: 75.6173% (minimum 98%, Approved); amygdala: 42.6829% (minimum 99%, Missing); basal ganglia: 44.1441% (minimum 99%, Missing); bone marrow: 97.2222% (minimum 99%, Missing); cerebellum: 80.8581% (minimum 99%, Missing); cerebral cortex: 55.8087% (minimum 99%, Missing); choroid plexus: 70.6052% (minimum 99%, Missing); colon: 58.8942% (minimum 97%, Missing); duodenum: 65.3333% (minimum 99%, Missing); esophagus: 60.9453% (minimum 97%, Missing); heart muscle: 64.1361% (minimum 99%, Missing); hippocampal formation: 46.0526% (minimum 99%, Missing); hypothalamus: 53.0303% (minimum 99%, Missing); kidney: 56.8445% (minimum 99%, Missing); liver: 72.4852% (minimum 99%, Missing); lung: 64.8148% (minimum 99%, Missing); lymph node: 84.4828% (minimum 95%, Approved); midbrain: 40.8333% (minimum 99%, Missing); pancreas: 64.1361% (minimum 99%, Missing); parathyroid gland: 49.7967% (minimum 97%, Missing); pituitary gland: 81.6667% (minimum 99%, Missing); rectum: 64.6438% (minimum 95%, Approved); retina: 91.7603% (minimum 99%, Missing); salivary gland: 58.7530% (minimum 97%, Missing); skeletal muscle: 83.0508% (minimum 98%, Approved); skin: 42.9825% (minimum 95%, Missing); small intestine: 62.6598% (minimum 99%, Missing); smooth muscle: 56.9767% (minimum 99%, Missing); spinal cord: 45.2030% (minimum 99%, Missing); spleen: 71.6374% (minimum 95%, Missing); stomach: 65.5080% (minimum 97%, Missing); thymus: 74.6951% (minimum 95%, Missing); thyroid gland: 48.7078% (minimum 95%, Missing); tongue: 70.8092% (minimum 97%, Missing); urinary bladder: 60.6436% (minimum 97%, Missing)",0,7,partial,35.5,24.7,32.5,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); skin: 32.5 nTPM (manageable, limit 5); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (manageable, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 2); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 2); colon: 17.1 nTPM (protected, limit 2); urinary bladder: 15.9 nTPM (protected, limit 2); esophagus: 15.7 nTPM (protected, limit 2); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 4); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 2); spleen: 9.7 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.9 nTPM (vital, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 2); lymph node: 4.5 nTPM (protected, limit 4); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000150760,DOCK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.520175,-0.472033,-0.581667
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12,4,5.2,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4 nTPM (protected, limit 2); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150773,PIH1D2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4733% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.7273% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.8468% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6239% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.0243% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.3984% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.1735% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.1386% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.8468% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.5748% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9264% (minimum 99%, Baseline (adaptation disabled)); lung: 95.8395% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.0243% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.3232% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.1606% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.2733% (minimum 99%, Baseline (adaptation disabled)); retina: 84.3137% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.4733% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7749% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 92.5395% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,12,4,5.2,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4 nTPM (protected, limit 2); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150773,PIH1D2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0246055,-0.0283942,-0.146863
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4733% (minimum 99%, Missing); amygdala: 97.7273% (minimum 99%, Missing); basal ganglia: 96.8468% (minimum 99%, Missing); cerebellum: 98.6239% (minimum 99%, Missing); cerebral cortex: 98.0243% (minimum 99%, Missing); choroid plexus: 87.3984% (minimum 99%, Missing); heart muscle: 98.1735% (minimum 99%, Missing); hippocampal formation: 97.1386% (minimum 99%, Missing); hypothalamus: 96.8468% (minimum 99%, Missing); kidney: 94.5748% (minimum 99%, Missing); liver: 98.9264% (minimum 99%, Missing); lung: 95.8395% (minimum 99%, Missing); midbrain: 98.0243% (minimum 99%, Missing); pancreas: 98.3232% (minimum 99%, Missing); parathyroid gland: 94.1606% (minimum 97%, Missing); pituitary gland: 95.2733% (minimum 99%, Missing); retina: 84.3137% (minimum 99%, Missing); skeletal muscle: 98.4733% (minimum 99%, Missing); spinal cord: 98.7749% (minimum 99%, Missing); thyroid gland: 92.5395% (minimum 95%, Missing)",0,80,unavailable,12,4,5.2,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4 nTPM (protected, limit 2); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150773,PIH1D2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0246055,-0.0283942,-0.146863
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,32.4,13.8,16.5,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 2); thymus: 16.5 nTPM (manageable, limit 5); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 2); adipose tissue: 13.7 nTPM (manageable, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 4); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 4); salivary gland: 13.3 nTPM (protected, limit 2); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 2); spleen: 12.3 nTPM (manageable, limit 10); smooth muscle: 12 nTPM (vital, limit 2); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); colon: 11.8 nTPM (protected, limit 2); liver: 11.4 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 2); stomach: 11.2 nTPM (protected, limit 2); urinary bladder: 11.1 nTPM (protected, limit 2); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 2); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000150776,NKAPD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1045% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.2857% (minimum 99%, Baseline (adaptation disabled)); amygdala: 60.1824% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.4606% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.7362% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 47.4820% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.4071% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.2628% (minimum 99%, Baseline (adaptation disabled)); colon: 62.6582% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.2857% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.6386% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.1111% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 60.5505% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.7537% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.4071% (minimum 99%, Baseline (adaptation disabled)); liver: 63.4615% (minimum 99%, Baseline (adaptation disabled)); lung: 64.9180% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.9286% (minimum 97%, Baseline (adaptation disabled)); midbrain: 59.4595% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.4606% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.2814% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.5275% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.6656% (minimum 97%, Baseline (adaptation disabled)); retina: 37.9310% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.8187% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 52.5199% (minimum 99%, Baseline (adaptation disabled)); skin: 62.6582% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.7059% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.2642% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.2814% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.6822% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.8710% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.5455% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.0907% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.1186% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.0777% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,32.4,13.8,16.5,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 1); thymus: 16.5 nTPM (manageable, limit 5); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 2); adipose tissue: 13.7 nTPM (manageable, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 2); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 2); salivary gland: 13.3 nTPM (protected, limit 2); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); smooth muscle: 12 nTPM (vital, limit 1); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); colon: 11.8 nTPM (protected, limit 2); liver: 11.4 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 2); stomach: 11.2 nTPM (protected, limit 2); urinary bladder: 11.1 nTPM (protected, limit 2); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 2); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000150776,NKAPD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.404545,-0.380714,-0.61069
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1045% (minimum 95%, Missing); adrenal gland: 64.2857% (minimum 99%, Missing); amygdala: 60.1824% (minimum 99%, Missing); basal ganglia: 62.4606% (minimum 99%, Missing); bone marrow: 60.7362% (minimum 99%, Missing); cerebellum: 47.4820% (minimum 99%, Missing); cerebral cortex: 58.4071% (minimum 99%, Missing); choroid plexus: 72.2628% (minimum 99%, Missing); colon: 62.6582% (minimum 97%, Missing); duodenum: 64.2857% (minimum 99%, Missing); esophagus: 59.6386% (minimum 95%, Approved); heart muscle: 61.1111% (minimum 98%, Approved); hippocampal formation: 60.5505% (minimum 99%, Missing); hypothalamus: 58.7537% (minimum 99%, Missing); kidney: 58.4071% (minimum 99%, Missing); liver: 63.4615% (minimum 99%, Missing); lung: 64.9180% (minimum 99%, Missing); lymph node: 58.9286% (minimum 97%, Missing); midbrain: 59.4595% (minimum 99%, Missing); pancreas: 62.4606% (minimum 99%, Missing); parathyroid gland: 59.2814% (minimum 95%, Approved); pituitary gland: 72.5275% (minimum 99%, Missing); rectum: 63.6656% (minimum 97%, Missing); retina: 37.9310% (minimum 99%, Missing); salivary gland: 59.8187% (minimum 97%, Missing); skeletal muscle: 52.5199% (minimum 98%, Approved); skin: 62.6582% (minimum 95%, Missing); small intestine: 64.7059% (minimum 99%, Missing); smooth muscle: 62.2642% (minimum 98%, Approved); spinal cord: 59.2814% (minimum 99%, Missing); spleen: 61.6822% (minimum 90%, Approved); stomach: 63.8710% (minimum 97%, Missing); thymus: 54.5455% (minimum 95%, Missing); thyroid gland: 56.0907% (minimum 95%, Missing); tongue: 67.1186% (minimum 97%, Missing); urinary bladder: 64.0777% (minimum 97%, Missing)",0,5,partial,32.4,13.8,16.5,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 2); thymus: 16.5 nTPM (manageable, limit 5); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 2); adipose tissue: 13.7 nTPM (manageable, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 4); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 4); salivary gland: 13.3 nTPM (protected, limit 2); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 2); spleen: 12.3 nTPM (manageable, limit 10); smooth muscle: 12 nTPM (vital, limit 2); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); colon: 11.8 nTPM (protected, limit 2); liver: 11.4 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 2); stomach: 11.2 nTPM (protected, limit 2); urinary bladder: 11.1 nTPM (protected, limit 2); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 2); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000150776,NKAPD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.404545,-0.380714,-0.61069
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,8.4,0.7,0.7,"retina: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150783,TEX12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.0488% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.5728% (minimum 99%, Baseline (adaptation disabled)); retina: 70.5263% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.7143% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.0488% (minimum 99%, Baseline (adaptation disabled)); tongue: 96.6346% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,8.4,0.7,0.7,"retina: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150783,TEX12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0163462,-0.00365385,-0.284737
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.5263% (minimum 99%, Missing); tongue: 96.6346% (minimum 97%, Missing)",0,1,partial,8.4,0.7,0.7,"retina: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000150783,TEX12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0450495,-0.00365385,-0.284737
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000151005,TKTL2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000151005,TKTL2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0482206,0.03,0.00822064
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000151005,TKTL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0482206,0.03,0.00822064
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000151033,LYZL2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000151033,LYZL2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000151033,LYZL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,19.5,0.4,0.3,"retina: 19.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus,ENSG00000151062,CACNA2D4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 60.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 50.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.0000% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 1.5152% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); thymus: 75.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 42.8571% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,19.5,0.4,0.3,"retina: 19.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus,ENSG00000151062,CACNA2D4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.541429,-0.974848
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 60.0000% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 50.0000% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 75.0000% (minimum 97%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); lung: 60.0000% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pituitary gland: 60.0000% (minimum 99%, Missing); retina: 1.5152% (minimum 99%, Missing); salivary gland: 75.0000% (minimum 97%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 60.0000% (minimum 99%, Missing); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); thymus: 75.0000% (minimum 95%, Missing); tongue: 42.8571% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",0,80,unavailable,19.5,0.4,0.3,"retina: 19.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus,ENSG00000151062,CACNA2D4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.541429,-0.974848
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,1,partial,0.8,0.5,0.4,,skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151164,RAD9B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.4912% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.4912% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.3451% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.3451% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.0171% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.4912% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.3451% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2143% (minimum 99%, Baseline (adaptation disabled)); liver: 97.3451% (minimum 99%, Baseline (adaptation disabled)); lung: 97.3451% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.6522% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.6522% (minimum 99%, Baseline (adaptation disabled)); retina: 96.4912% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 93.2203% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.4912% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.0171% (minimum 99%, Baseline (adaptation disabled)); tongue: 95.6522% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,0.8,0.5,0.4,,skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151164,RAD9B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0149123,-0.0134783,-0.0577966
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.4912% (minimum 99%, Missing); basal ganglia: 96.4912% (minimum 99%, Missing); bone marrow: 97.3451% (minimum 98%, Approved); cerebral cortex: 97.3451% (minimum 98%, Approved); heart muscle: 94.0171% (minimum 98%, Approved); hippocampal formation: 96.4912% (minimum 99%, Missing); hypothalamus: 97.3451% (minimum 99%, Missing); liver: 97.3451% (minimum 98%, Approved); lung: 97.3451% (minimum 98%, Approved); midbrain: 95.6522% (minimum 99%, Missing); retina: 96.4912% (minimum 99%, Missing); skeletal muscle: 93.2203% (minimum 99%, Missing); smooth muscle: 96.4912% (minimum 98%, Approved); spinal cord: 94.0171% (minimum 99%, Missing); tongue: 95.6522% (minimum 97%, Missing)",0,1,partial,0.8,0.5,0.4,,skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151164,RAD9B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0149123,-0.0134783,-0.0577966
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,9,partial,56.6,52.4,51.8,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 2); retina: 52.4 nTPM (vital, limit 1); thymus: 51.8 nTPM (manageable, limit 5); thyroid gland: 51 nTPM (manageable, limit 5); rectum: 50.6 nTPM (protected, limit 2); esophagus: 50 nTPM (protected, limit 2); tongue: 46.3 nTPM (protected, limit 2); kidney: 45.7 nTPM (vital, limit 1); colon: 43.6 nTPM (protected, limit 2); lymph node: 43.6 nTPM (protected, limit 2); parathyroid gland: 43.5 nTPM (protected, limit 2); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); adipose tissue: 36.6 nTPM (manageable, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 2); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); spleen: 30.6 nTPM (manageable, limit 5); salivary gland: 30.3 nTPM (protected, limit 2); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); skin: 23.4 nTPM (manageable, limit 5); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: High (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / eccrine glands: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: High (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: High (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000151247,EIF4E,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.3844% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.5773% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.3360% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.4959% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 51.7477% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.4867% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.5129% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.4114% (minimum 99%, Baseline (adaptation disabled)); colon: 58.1975% (minimum 97%, Baseline (adaptation disabled)); duodenum: 63.4274% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.8329% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.6419% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.8691% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.7033% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.0489% (minimum 99%, Baseline (adaptation disabled)); liver: 59.1042% (minimum 99%, Baseline (adaptation disabled)); lung: 69.8504% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.1975% (minimum 97%, Baseline (adaptation disabled)); midbrain: 67.4444% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.7701% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.2534% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.5252% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.5373% (minimum 97%, Baseline (adaptation disabled)); retina: 53.6693% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.7033% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.6244% (minimum 99%, Baseline (adaptation disabled)); skin: 72.1760% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.4374% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.5619% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.9668% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.4841% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.4937% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.9556% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.3420% (minimum 95%, Baseline (adaptation disabled)); tongue: 56.7290% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.6693% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,56.6,52.4,51.8,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 2); retina: 52.4 nTPM (vital, limit 1); thymus: 51.8 nTPM (manageable, limit 5); thyroid gland: 51 nTPM (manageable, limit 5); rectum: 50.6 nTPM (protected, limit 2); esophagus: 50 nTPM (protected, limit 2); tongue: 46.3 nTPM (protected, limit 2); kidney: 45.7 nTPM (vital, limit 1); colon: 43.6 nTPM (protected, limit 2); lymph node: 43.6 nTPM (protected, limit 2); parathyroid gland: 43.5 nTPM (protected, limit 2); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); adipose tissue: 36.6 nTPM (manageable, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 2); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); spleen: 30.6 nTPM (manageable, limit 5); salivary gland: 30.3 nTPM (protected, limit 2); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); skin: 23.4 nTPM (manageable, limit 5); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: High (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / eccrine glands: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: High (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: High (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000151247,EIF4E,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.410444,-0.433307,-0.472523
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.3844% (minimum 95%, Missing); adrenal gland: 62.5773% (minimum 99%, Missing); amygdala: 70.3360% (minimum 99%, Missing); basal ganglia: 71.4959% (minimum 99%, Missing); bone marrow: 51.7477% (minimum 99%, Missing); cerebellum: 73.4867% (minimum 99%, Missing); cerebral cortex: 62.5129% (minimum 99%, Missing); choroid plexus: 66.4114% (minimum 99%, Missing); colon: 58.1975% (minimum 97%, Missing); duodenum: 63.4274% (minimum 99%, Missing); esophagus: 54.8329% (minimum 97%, Missing); heart muscle: 62.6419% (minimum 99%, Missing); hippocampal formation: 72.8691% (minimum 99%, Missing); hypothalamus: 66.7033% (minimum 99%, Missing); kidney: 57.0489% (minimum 99%, Missing); liver: 59.1042% (minimum 99%, Missing); lung: 69.8504% (minimum 99%, Missing); lymph node: 58.1975% (minimum 97%, Missing); midbrain: 67.4444% (minimum 99%, Missing); pancreas: 69.7701% (minimum 99%, Missing); parathyroid gland: 58.2534% (minimum 97%, Missing); pituitary gland: 78.5252% (minimum 99%, Missing); rectum: 54.5373% (minimum 97%, Missing); retina: 53.6693% (minimum 99%, Missing); salivary gland: 66.7033% (minimum 97%, Missing); skeletal muscle: 61.6244% (minimum 99%, Missing); skin: 72.1760% (minimum 95%, Missing); small intestine: 64.4374% (minimum 99%, Missing); smooth muscle: 61.5619% (minimum 99%, Missing); spinal cord: 62.9668% (minimum 99%, Missing); spleen: 66.4841% (minimum 95%, Missing); stomach: 63.4937% (minimum 97%, Missing); thymus: 53.9556% (minimum 95%, Missing); thyroid gland: 54.3420% (minimum 95%, Missing); tongue: 56.7290% (minimum 97%, Missing); urinary bladder: 53.6693% (minimum 97%, Missing)",0,9,partial,56.6,52.4,51.8,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 2); retina: 52.4 nTPM (vital, limit 1); thymus: 51.8 nTPM (manageable, limit 5); thyroid gland: 51 nTPM (manageable, limit 5); rectum: 50.6 nTPM (protected, limit 2); esophagus: 50 nTPM (protected, limit 2); tongue: 46.3 nTPM (protected, limit 2); kidney: 45.7 nTPM (vital, limit 1); colon: 43.6 nTPM (protected, limit 2); lymph node: 43.6 nTPM (protected, limit 2); parathyroid gland: 43.5 nTPM (protected, limit 2); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); adipose tissue: 36.6 nTPM (manageable, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 2); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); spleen: 30.6 nTPM (manageable, limit 5); salivary gland: 30.3 nTPM (protected, limit 2); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); skin: 23.4 nTPM (manageable, limit 5); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: High (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / eccrine glands: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: High (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: High (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000151247,EIF4E,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.410444,-0.433307,-0.472523
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,38.8,11.6,15.7,"liver: 38.8 nTPM (vital, limit 6); kidney: 18.5 nTPM (vital, limit 6); thymus: 15.7 nTPM (manageable, limit 5); bone marrow: 14.2 nTPM (vital, limit 6); lymph node: 11.6 nTPM (protected, limit 2); cerebellum: 10.8 nTPM (vital, limit 6); cerebral cortex: 9.9 nTPM (vital, limit 6); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 6); tongue: 9 nTPM (protected, limit 2); heart muscle: 8.8 nTPM (vital, limit 6); amygdala: 8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 6); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1)",skin 1 / cells in corneal layer: High (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 2 / cells in corneal layer; spleen; thymus; tonsil,ENSG00000151287,TEX30,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.5636% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.3600% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.7107% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.3600% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.3553% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.6923% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.3315% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.8290% (minimum 99%, Baseline (adaptation disabled)); colon: 95.6661% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.7430% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.6371% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.1250% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.8290% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.6185% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.5650% (minimum 99%, Baseline (adaptation disabled)); liver: 75.4430% (minimum 99%, Baseline (adaptation disabled)); lung: 95.4363% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.1315% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.8583% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.5894% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.5964% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.4532% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.4401% (minimum 97%, Baseline (adaptation disabled)); retina: 94.2292% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.8970% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.6905% (minimum 99%, Baseline (adaptation disabled)); skin: 94.2292% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.8199% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.4532% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.8583% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.9801% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.5894% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.3617% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.9797% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.7536% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,38.8,11.6,15.7,"liver: 38.8 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); thymus: 15.7 nTPM (manageable, limit 5); bone marrow: 14.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 2); cerebellum: 10.8 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 2); amygdala: 8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); retina: 7.3 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 2); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); spleen: 6.3 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); colon: 5.4 nTPM (protected, limit 2); duodenum: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); parathyroid gland: 4.2 nTPM (protected, limit 2)",skin 1 / cells in corneal layer: High (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 2 / cells in corneal layer; spleen; thymus; tonsil,ENSG00000151287,TEX30,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0663825,-0.058685,-0.23557
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.7107% (minimum 99%, Missing); basal ganglia: 95.3600% (minimum 99%, Missing); bone marrow: 89.3553% (minimum 95%, Enhanced); cerebellum: 91.6923% (minimum 95%, Enhanced); cerebral cortex: 92.3315% (minimum 95%, Enhanced); choroid plexus: 94.8290% (minimum 99%, Missing); heart muscle: 93.1250% (minimum 95%, Enhanced); hippocampal formation: 94.8290% (minimum 99%, Missing); hypothalamus: 92.6185% (minimum 99%, Missing); kidney: 86.5650% (minimum 95%, Enhanced); liver: 75.4430% (minimum 95%, Enhanced); lymph node: 91.1315% (minimum 97%, Missing); midbrain: 93.8583% (minimum 99%, Missing); pituitary gland: 94.4532% (minimum 99%, Missing); retina: 94.2292% (minimum 99%, Missing); skeletal muscle: 92.6905% (minimum 95%, Enhanced); skin: 94.2292% (minimum 95%, Missing); smooth muscle: 94.4532% (minimum 95%, Enhanced); spinal cord: 93.8583% (minimum 99%, Missing); thymus: 88.3617% (minimum 95%, Missing); tongue: 92.9797% (minimum 97%, Missing)",0,8,partial,38.8,11.6,15.7,"liver: 38.8 nTPM (vital, limit 6); kidney: 18.5 nTPM (vital, limit 6); thymus: 15.7 nTPM (manageable, limit 5); bone marrow: 14.2 nTPM (vital, limit 6); lymph node: 11.6 nTPM (protected, limit 2); cerebellum: 10.8 nTPM (vital, limit 6); cerebral cortex: 9.9 nTPM (vital, limit 6); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 6); tongue: 9 nTPM (protected, limit 2); heart muscle: 8.8 nTPM (vital, limit 6); amygdala: 8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 6); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1)",skin 1 / cells in corneal layer: High (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 2 / cells in corneal layer; spleen; thymus; tonsil,ENSG00000151287,TEX30,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0663825,-0.058685,-0.19557
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,4.2,6.7,5.6,"parathyroid gland: 6.7 nTPM (protected, limit 2); thyroid gland: 5.6 nTPM (manageable, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); lung: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000151338,MIPOL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.3585% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.8739% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.3158% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.4167% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.1348% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.3488% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.3922% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.5361% (minimum 99%, Baseline (adaptation disabled)); colon: 76.6355% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.6735% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.2143% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.2294% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.2340% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.6735% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 82.8283% (minimum 99%, Baseline (adaptation disabled)); lung: 76.6355% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.3488% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.5361% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.1290% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.0336% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.9259% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.3922% (minimum 97%, Baseline (adaptation disabled)); retina: 73.2143% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.5664% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.1881% (minimum 99%, Baseline (adaptation disabled)); skin: 83.6735% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.5361% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.3043% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.3922% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.4167% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.0855% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.1099% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.4203% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.2294% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.9298% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,4.2,6.7,5.6,"parathyroid gland: 6.7 nTPM (protected, limit 2); thyroid gland: 5.6 nTPM (manageable, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); lung: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000151338,MIPOL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.355797,-0.419664,-0.32871
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.3585% (minimum 95%, Missing); adrenal gland: 73.8739% (minimum 99%, Missing); amygdala: 86.3158% (minimum 99%, Missing); basal ganglia: 85.4167% (minimum 99%, Missing); bone marrow: 92.1348% (minimum 95%, Enhanced); cerebellum: 95.3488% (minimum 99%, Missing); cerebral cortex: 80.3922% (minimum 99%, Missing); choroid plexus: 84.5361% (minimum 99%, Missing); colon: 76.6355% (minimum 97%, Missing); duodenum: 83.6735% (minimum 99%, Missing); esophagus: 73.2143% (minimum 97%, Missing); heart muscle: 75.2294% (minimum 99%, Missing); hippocampal formation: 87.2340% (minimum 99%, Missing); hypothalamus: 83.6735% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 82.8283% (minimum 99%, Missing); lung: 76.6355% (minimum 99%, Missing); lymph node: 95.3488% (minimum 97%, Missing); midbrain: 84.5361% (minimum 99%, Missing); pancreas: 66.1290% (minimum 99%, Missing); parathyroid gland: 55.0336% (minimum 97%, Missing); pituitary gland: 75.9259% (minimum 99%, Missing); rectum: 80.3922% (minimum 97%, Missing); retina: 73.2143% (minimum 99%, Missing); salivary gland: 72.5664% (minimum 97%, Missing); skeletal muscle: 81.1881% (minimum 99%, Missing); skin: 83.6735% (minimum 95%, Missing); small intestine: 84.5361% (minimum 99%, Missing); smooth muscle: 71.3043% (minimum 99%, Missing); spinal cord: 80.3922% (minimum 99%, Missing); spleen: 85.4167% (minimum 95%, Missing); stomach: 70.0855% (minimum 97%, Missing); thymus: 90.1099% (minimum 95%, Missing); thyroid gland: 59.4203% (minimum 95%, Missing); tongue: 75.2294% (minimum 97%, Missing); urinary bladder: 71.9298% (minimum 97%, Missing)",0,3,partial,4.2,6.7,5.6,"parathyroid gland: 6.7 nTPM (protected, limit 2); thyroid gland: 5.6 nTPM (manageable, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); lung: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000151338,MIPOL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.355797,-0.419664,-0.32871
True,compatible,,True,True,False,,0,80,unavailable,0.6,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,ENSG00000151360,ALLC,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 97.5610% (minimum 99%, Baseline (adaptation disabled)); liver: 96.3855% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,ENSG00000151360,ALLC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0437888,0.03,-0.0261446
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 97.5610% (minimum 99%, Missing); liver: 96.3855% (minimum 99%, Missing)",0,80,unavailable,0.6,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,ENSG00000151360,ALLC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0437888,0.03,-0.0261446
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells,ENSG00000151475,SLC25A31,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,0,routine_complete,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells,ENSG00000151475,SLC25A31,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00782609
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,0,routine_complete,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells,ENSG00000151475,SLC25A31,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00782609
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9,7,7.8,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); salivary gland: 7 nTPM (protected, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151575,TEX9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.0635% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.9116% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.5556% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.8170% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.3089% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.5484% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.8788% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.0435% (minimum 99%, Baseline (adaptation disabled)); colon: 86.5672% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.2353% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.3784% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.0820% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.8212% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.1656% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.8045% (minimum 99%, Baseline (adaptation disabled)); liver: 94.3089% (minimum 99%, Baseline (adaptation disabled)); lung: 84.0580% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.1189% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.1189% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.7363% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.3107% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.0580% (minimum 97%, Baseline (adaptation disabled)); retina: 67.0520% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.3656% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.4790% (minimum 99%, Baseline (adaptation disabled)); skin: 83.4532% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.3247% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.8000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.2941% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.8363% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.5496% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.7938% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.0820% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.5496% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9,7,7.8,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); salivary gland: 7 nTPM (protected, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151575,TEX9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.352062,-0.346344,-0.426893
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.0635% (minimum 95%, Missing); adrenal gland: 78.9116% (minimum 99%, Missing); amygdala: 80.5556% (minimum 99%, Missing); basal ganglia: 75.8170% (minimum 99%, Missing); bone marrow: 94.3089% (minimum 99%, Missing); cerebellum: 93.5484% (minimum 99%, Missing); cerebral cortex: 87.8788% (minimum 99%, Missing); choroid plexus: 63.0435% (minimum 99%, Missing); colon: 86.5672% (minimum 97%, Missing); duodenum: 68.2353% (minimum 99%, Missing); esophagus: 78.3784% (minimum 97%, Missing); heart muscle: 95.0820% (minimum 99%, Missing); hippocampal formation: 76.8212% (minimum 99%, Missing); hypothalamus: 71.1656% (minimum 99%, Missing); kidney: 64.8045% (minimum 99%, Missing); liver: 94.3089% (minimum 99%, Missing); lung: 84.0580% (minimum 99%, Missing); lymph node: 81.1189% (minimum 97%, Missing); midbrain: 81.1189% (minimum 99%, Missing); pancreas: 80.0000% (minimum 99%, Missing); parathyroid gland: 63.7363% (minimum 97%, Missing); pituitary gland: 56.3107% (minimum 99%, Missing); rectum: 84.0580% (minimum 97%, Missing); retina: 67.0520% (minimum 99%, Missing); salivary gland: 62.3656% (minimum 97%, Missing); skeletal muscle: 97.4790% (minimum 99%, Missing); skin: 83.4532% (minimum 95%, Missing); small intestine: 75.3247% (minimum 99%, Missing); smooth muscle: 92.8000% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 85.2941% (minimum 95%, Missing); stomach: 67.8363% (minimum 97%, Missing); thymus: 88.5496% (minimum 95%, Missing); thyroid gland: 59.7938% (minimum 95%, Missing); tongue: 95.0820% (minimum 97%, Missing); urinary bladder: 88.5496% (minimum 97%, Missing)",0,80,unavailable,9,7,7.8,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); salivary gland: 7 nTPM (protected, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 2); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151575,TEX9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.352062,-0.346344,-0.426893
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,3.2,0,0,"basal ganglia: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000151577,DRD3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"basal ganglia: 15.7895% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.7143% (minimum 99%, Baseline (adaptation disabled)); retina: 85.7143% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.2,0,0,"basal ganglia: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000151577,DRD3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.832105
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"basal ganglia: 15.7895% (minimum 99%, Missing); hypothalamus: 85.7143% (minimum 99%, Missing); retina: 85.7143% (minimum 99%, Missing)",0,80,unavailable,3.2,0,0,"basal ganglia: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000151577,DRD3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.832105
True,compatible,,True,True,False,,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,ENSG00000151615,POU4F2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 83.3333% (minimum 99%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,ENSG00000151615,POU4F2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.49
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 83.3333% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing)",0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,ENSG00000151615,POU4F2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.49
True,compatible,,True,True,False,,0,80,unavailable,0.6,0.6,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151687,ANKAR,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.5517% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.5517% (minimum 99%, Baseline (adaptation disabled)); colon: 96.5517% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.5517% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2456% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.5517% (minimum 99%, Baseline (adaptation disabled)); liver: 94.9153% (minimum 99%, Baseline (adaptation disabled)); lung: 94.9153% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.8033% (minimum 97%, Baseline (adaptation disabled)); pancreas: 91.8033% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.3226% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.2456% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 90.3226% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.8033% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.2456% (minimum 99%, Baseline (adaptation disabled)); skin: 94.9153% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.9153% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.5517% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.8033% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 91.8033% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.5517% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.6,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151687,ANKAR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0319672,-0.0667742,-0.0867742
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 93.3333% (minimum 99%, Missing); bone marrow: 96.5517% (minimum 99%, Missing); choroid plexus: 96.5517% (minimum 99%, Missing); colon: 96.5517% (minimum 97%, Missing); duodenum: 96.5517% (minimum 99%, Missing); heart muscle: 98.2456% (minimum 99%, Missing); kidney: 96.5517% (minimum 99%, Missing); liver: 94.9153% (minimum 99%, Missing); lung: 94.9153% (minimum 99%, Missing); lymph node: 91.8033% (minimum 97%, Missing); pancreas: 91.8033% (minimum 99%, Missing); parathyroid gland: 90.3226% (minimum 97%, Missing); pituitary gland: 98.2456% (minimum 99%, Missing); rectum: 93.3333% (minimum 97%, Missing); retina: 90.3226% (minimum 99%, Missing); salivary gland: 91.8033% (minimum 97%, Missing); skeletal muscle: 98.2456% (minimum 99%, Missing); skin: 94.9153% (minimum 95%, Missing); small intestine: 94.9153% (minimum 99%, Missing); smooth muscle: 96.5517% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Missing); stomach: 91.8033% (minimum 97%, Missing); thyroid gland: 91.8033% (minimum 95%, Missing); urinary bladder: 96.5517% (minimum 97%, Missing)",0,80,unavailable,0.6,0.6,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151687,ANKAR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0319672,-0.0667742,-0.0867742
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,61.8,15.8,14.9,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 2); skin: 14.9 nTPM (manageable, limit 5); thymus: 12.5 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 2); rectum: 7.8 nTPM (protected, limit 2); colon: 7.5 nTPM (protected, limit 2); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151725,CENPU,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.2963% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.9619% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.9619% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 31.6372% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2818% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.6216% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.6207% (minimum 99%, Baseline (adaptation disabled)); colon: 79.2244% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.3731% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.9018% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9619% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.6109% (minimum 99%, Baseline (adaptation disabled)); liver: 88.8199% (minimum 99%, Baseline (adaptation disabled)); lung: 94.3894% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.4144% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.9619% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.9492% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.3333% (minimum 97%, Baseline (adaptation disabled)); rectum: 78.5714% (minimum 97%, Baseline (adaptation disabled)); retina: 95.0166% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.9492% (minimum 99%, Baseline (adaptation disabled)); skin: 65.7471% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.6154% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2818% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.5566% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.8199% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.5864% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.4641% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,61.8,15.8,14.9,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 2); skin: 14.9 nTPM (manageable, limit 5); thymus: 12.5 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 2); rectum: 7.8 nTPM (protected, limit 2); colon: 7.5 nTPM (protected, limit 2); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151725,CENPU,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.292529,-0.325856,-0.673628
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.2963% (minimum 99%, Missing); amygdala: 98.9619% (minimum 99%, Missing); basal ganglia: 98.9619% (minimum 99%, Missing); bone marrow: 31.6372% (minimum 99%, Missing); cerebellum: 98.2818% (minimum 99%, Missing); cerebral cortex: 96.6216% (minimum 99%, Missing); choroid plexus: 98.6207% (minimum 99%, Missing); colon: 79.2244% (minimum 97%, Missing); duodenum: 85.3731% (minimum 99%, Missing); esophagus: 73.9018% (minimum 97%, Missing); heart muscle: 95.3333% (minimum 99%, Missing); hippocampal formation: 98.9619% (minimum 99%, Missing); kidney: 97.6109% (minimum 99%, Missing); liver: 88.8199% (minimum 99%, Missing); lung: 94.3894% (minimum 99%, Missing); lymph node: 64.4144% (minimum 97%, Missing); midbrain: 98.9619% (minimum 99%, Missing); pancreas: 96.9492% (minimum 99%, Missing); parathyroid gland: 95.3333% (minimum 97%, Missing); rectum: 78.5714% (minimum 97%, Missing); retina: 95.0166% (minimum 99%, Missing); salivary gland: 91.6667% (minimum 97%, Missing); skeletal muscle: 96.9492% (minimum 99%, Missing); skin: 65.7471% (minimum 95%, Missing); small intestine: 84.6154% (minimum 99%, Missing); smooth muscle: 91.6667% (minimum 99%, Missing); spinal cord: 98.2818% (minimum 99%, Missing); spleen: 92.5566% (minimum 95%, Missing); stomach: 88.8199% (minimum 97%, Missing); thymus: 69.5864% (minimum 95%, Missing); urinary bladder: 93.4641% (minimum 97%, Missing)",0,80,unavailable,61.8,15.8,14.9,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 2); skin: 14.9 nTPM (manageable, limit 5); thymus: 12.5 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 2); rectum: 7.8 nTPM (protected, limit 2); colon: 7.5 nTPM (protected, limit 2); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151725,CENPU,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.292529,-0.325856,-0.673628
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,4.5,3.9,4.8,"heart muscle: 4.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 2); rectum: 3.4 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000151773,CCDC122,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.4321% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.3030% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.8116% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.4839% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.8305% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.8116% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 65.4321% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.8116% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.6027% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.0816% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.6479% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.9412% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.6341% (minimum 99%, Baseline (adaptation disabled)); liver: 69.7368% (minimum 99%, Baseline (adaptation disabled)); lung: 72.6027% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.2500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.6479% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.2273% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.6087% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.0952% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.9195% (minimum 97%, Baseline (adaptation disabled)); retina: 89.8305% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.0952% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.1270% (minimum 99%, Baseline (adaptation disabled)); skin: 57.6087% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.8312% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.3529% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.6111% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.6341% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.8554% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.6027% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.4752% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.6429% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.4321% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,4.5,3.9,4.8,"heart muscle: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); pancreas: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000151773,CCDC122,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.425248,-0.393913,-0.449184
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.6667% (minimum 90%, Approved); adrenal gland: 65.4321% (minimum 99%, Missing); amygdala: 80.3030% (minimum 99%, Missing); basal ganglia: 76.8116% (minimum 99%, Missing); bone marrow: 85.4839% (minimum 98%, Approved); cerebellum: 89.8305% (minimum 99%, Missing); cerebral cortex: 76.8116% (minimum 99%, Missing); choroid plexus: 88.3333% (minimum 99%, Missing); colon: 65.4321% (minimum 97%, Missing); duodenum: 76.8116% (minimum 99%, Missing); esophagus: 72.6027% (minimum 97%, Missing); heart muscle: 54.0816% (minimum 99%, Missing); hippocampal formation: 74.6479% (minimum 99%, Missing); hypothalamus: 77.9412% (minimum 99%, Missing); kidney: 64.6341% (minimum 99%, Missing); liver: 69.7368% (minimum 99%, Missing); lung: 72.6027% (minimum 99%, Missing); lymph node: 66.2500% (minimum 97%, Missing); midbrain: 74.6479% (minimum 99%, Missing); pancreas: 60.2273% (minimum 98%, Approved); parathyroid gland: 57.6087% (minimum 95%, Approved); pituitary gland: 63.0952% (minimum 99%, Missing); rectum: 60.9195% (minimum 97%, Missing); retina: 89.8305% (minimum 99%, Missing); salivary gland: 63.0952% (minimum 97%, Missing); skeletal muscle: 84.1270% (minimum 99%, Missing); skin: 57.6087% (minimum 95%, Missing); small intestine: 68.8312% (minimum 99%, Missing); smooth muscle: 62.3529% (minimum 99%, Missing); spinal cord: 73.6111% (minimum 99%, Missing); spleen: 64.6341% (minimum 90%, Approved); stomach: 63.8554% (minimum 97%, Missing); thymus: 72.6027% (minimum 95%, Missing); thyroid gland: 52.4752% (minimum 95%, Missing); tongue: 94.6429% (minimum 97%, Missing); urinary bladder: 65.4321% (minimum 97%, Missing)",0,1,partial,4.5,3.9,4.8,"heart muscle: 4.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 2); rectum: 3.4 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000151773,CCDC122,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.425248,-0.373913,-0.449184
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.9,3.5,3.4,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151789,ZNF385D,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.5833% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.8750% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.5195% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.5432% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.8750% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 46.2687% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.9315% (minimum 99%, Baseline (adaptation disabled)); colon: 88.5714% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.8750% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.6098% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 78.4810% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.4810% (minimum 99%, Baseline (adaptation disabled)); liver: 95.3846% (minimum 99%, Baseline (adaptation disabled)); lung: 91.1765% (minimum 99%, Baseline (adaptation disabled)); lymph node: 89.8551% (minimum 97%, Baseline (adaptation disabled)); midbrain: 72.0930% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.9394% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.8750% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.4127% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.9394% (minimum 97%, Baseline (adaptation disabled)); retina: 43.9716% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.1765% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.9315% (minimum 99%, Baseline (adaptation disabled)); skin: 91.1765% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.5373% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.5789% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.8551% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.9394% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.1765% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.5373% (minimum 95%, Baseline (adaptation disabled)); tongue: 63.9175% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.8889% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7.9,3.5,3.4,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151789,ZNF385D,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.304167,-0.330825,-0.550284
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.5833% (minimum 95%, Missing); adrenal gland: 96.8750% (minimum 99%, Missing); amygdala: 80.5195% (minimum 99%, Missing); basal ganglia: 76.5432% (minimum 99%, Missing); bone marrow: 96.8750% (minimum 99%, Missing); cerebellum: 46.2687% (minimum 99%, Missing); cerebral cortex: 62.0000% (minimum 99%, Missing); choroid plexus: 84.9315% (minimum 99%, Missing); colon: 88.5714% (minimum 97%, Missing); duodenum: 96.8750% (minimum 99%, Missing); esophagus: 75.6098% (minimum 97%, Missing); heart muscle: 78.4810% (minimum 99%, Missing); hippocampal formation: 82.6667% (minimum 99%, Missing); hypothalamus: 82.6667% (minimum 99%, Missing); kidney: 78.4810% (minimum 99%, Missing); liver: 95.3846% (minimum 99%, Missing); lung: 91.1765% (minimum 99%, Missing); lymph node: 89.8551% (minimum 97%, Missing); midbrain: 72.0930% (minimum 99%, Missing); pancreas: 93.9394% (minimum 99%, Missing); parathyroid gland: 96.8750% (minimum 97%, Missing); pituitary gland: 98.4127% (minimum 99%, Missing); rectum: 93.9394% (minimum 97%, Missing); retina: 43.9716% (minimum 99%, Missing); salivary gland: 91.1765% (minimum 97%, Missing); skeletal muscle: 84.9315% (minimum 99%, Missing); skin: 91.1765% (minimum 95%, Missing); small intestine: 92.5373% (minimum 99%, Missing); smooth muscle: 81.5789% (minimum 99%, Missing); spinal cord: 89.8551% (minimum 99%, Missing); stomach: 93.9394% (minimum 97%, Missing); thymus: 91.1765% (minimum 95%, Missing); thyroid gland: 92.5373% (minimum 95%, Missing); tongue: 63.9175% (minimum 97%, Missing); urinary bladder: 68.8889% (minimum 97%, Missing)",0,80,unavailable,7.9,3.5,3.4,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000151789,ZNF385D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.304167,-0.330825,-0.550284
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,4,partial,0.4,0.8,0.5,,bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000151846,PABPC3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"pancreas: 98.8920% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,0.4,0.8,0.5,,bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000151846,PABPC3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0361878,0.00808219,-0.00108033
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,4,partial,0.4,0.8,0.5,,bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000151846,PABPC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0361878,0.00808219,0.00166667
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,ENSG00000151962,RBM46,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,ENSG00000151962,RBM46,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0352941,0.0262825,0.00628253
True,compatible,,True,True,True,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,ENSG00000151962,RBM46,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0352941,0.0262825,0.00628253
False,excluded,rna_above_tissue_ceiling;family_exclusion,True,True,False,,0,80,unavailable,51.5,0,0,"heart muscle: 51.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000152086,TUBA3E,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 76.7913% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,51.5,0,0,"heart muscle: 51.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000152086,TUBA3E,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.222087
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 76.7913% (minimum 99%, Missing)",0,80,unavailable,51.5,0,0,"heart muscle: 51.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000152086,TUBA3E,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.222087
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,69.2,52.4,40,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 12); tongue: 50.9 nTPM (protected, limit 2); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 2); bone marrow: 45.7 nTPM (vital, limit 6); parathyroid gland: 45.2 nTPM (protected, limit 12); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (manageable, limit 30); smooth muscle: 39.4 nTPM (vital, limit 6); thymus: 37.5 nTPM (manageable, limit 5); kidney: 37.1 nTPM (vital, limit 6); stomach: 35.2 nTPM (protected, limit 2); thyroid gland: 35.1 nTPM (manageable, limit 5); small intestine: 33.4 nTPM (vital, limit 6); esophagus: 33.3 nTPM (protected, limit 12); adrenal gland: 32.6 nTPM (vital, limit 6); rectum: 30.9 nTPM (protected, limit 12); liver: 30.1 nTPM (vital, limit 6); pancreas: 29.2 nTPM (vital, limit 6); salivary gland: 27.3 nTPM (protected, limit 12); lymph node: 27.1 nTPM (protected, limit 2); lung: 26.7 nTPM (vital, limit 6); duodenum: 25.6 nTPM (vital, limit 6); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152102,FAM168B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.3571% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.3406% (minimum 99%, Baseline (adaptation disabled)); amygdala: 47.4641% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 41.7508% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.0462% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.7004% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 42.1053% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.2550% (minimum 99%, Baseline (adaptation disabled)); colon: 48.6275% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.9574% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.8311% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.1485% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 47.5551% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 52.3759% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.2088% (minimum 99%, Baseline (adaptation disabled)); liver: 62.2334% (minimum 99%, Baseline (adaptation disabled)); lung: 65.0066% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.6675% (minimum 97%, Baseline (adaptation disabled)); midbrain: 47.5551% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.9442% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.3207% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.4697% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.6149% (minimum 97%, Baseline (adaptation disabled)); retina: 51.2927% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.4993% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 42.3932% (minimum 99%, Baseline (adaptation disabled)); skin: 63.1043% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.7590% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.7303% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 47.4641% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.7596% (minimum 95%, Baseline (adaptation disabled)); stomach: 58.4906% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.9460% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.5596% (minimum 95%, Baseline (adaptation disabled)); tongue: 49.3532% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.8286% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,69.2,52.4,40,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 2); tongue: 50.9 nTPM (protected, limit 2); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 2); bone marrow: 45.7 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 2); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (manageable, limit 5); smooth muscle: 39.4 nTPM (vital, limit 1); thymus: 37.5 nTPM (manageable, limit 5); kidney: 37.1 nTPM (vital, limit 1); stomach: 35.2 nTPM (protected, limit 2); thyroid gland: 35.1 nTPM (manageable, limit 5); small intestine: 33.4 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 2); adrenal gland: 32.6 nTPM (vital, limit 1); rectum: 30.9 nTPM (protected, limit 2); liver: 30.1 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); skin: 29 nTPM (manageable, limit 5); salivary gland: 27.3 nTPM (protected, limit 2); lymph node: 27.1 nTPM (protected, limit 2); lung: 26.7 nTPM (vital, limit 1); duodenum: 25.6 nTPM (vital, limit 1); spleen: 23.6 nTPM (manageable, limit 5); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152102,FAM168B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.396429,-0.483725,-0.572492
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.3571% (minimum 60%, Enhanced); adrenal gland: 60.3406% (minimum 95%, Enhanced); amygdala: 47.4641% (minimum 99%, Missing); basal ganglia: 41.7508% (minimum 99%, Missing); bone marrow: 52.0462% (minimum 95%, Enhanced); cerebellum: 43.7004% (minimum 99%, Missing); cerebral cortex: 42.1053% (minimum 99%, Missing); choroid plexus: 70.2550% (minimum 99%, Missing); colon: 48.6275% (minimum 80%, Enhanced); duodenum: 65.9574% (minimum 95%, Enhanced); esophagus: 59.8311% (minimum 80%, Enhanced); heart muscle: 54.1485% (minimum 99%, Missing); hippocampal formation: 47.5551% (minimum 99%, Missing); hypothalamus: 52.3759% (minimum 99%, Missing); kidney: 57.2088% (minimum 95%, Enhanced); liver: 62.2334% (minimum 95%, Enhanced); lung: 65.0066% (minimum 95%, Enhanced); lymph node: 64.6675% (minimum 97%, Missing); midbrain: 47.5551% (minimum 99%, Missing); pancreas: 62.9442% (minimum 95%, Enhanced); parathyroid gland: 52.3207% (minimum 80%, Enhanced); pituitary gland: 71.4697% (minimum 99%, Missing); rectum: 61.6149% (minimum 80%, Enhanced); retina: 51.2927% (minimum 99%, Missing); salivary gland: 64.4993% (minimum 80%, Enhanced); skeletal muscle: 42.3932% (minimum 99%, Missing); small intestine: 59.7590% (minimum 95%, Enhanced); smooth muscle: 55.7303% (minimum 95%, Enhanced); spinal cord: 47.4641% (minimum 99%, Missing); stomach: 58.4906% (minimum 97%, Missing); thymus: 56.9460% (minimum 95%, Missing); thyroid gland: 58.5596% (minimum 95%, Missing); tongue: 49.3532% (minimum 97%, Missing); urinary bladder: 51.8286% (minimum 97%, Missing)",0,2,partial,69.2,52.4,40,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 12); tongue: 50.9 nTPM (protected, limit 2); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 2); bone marrow: 45.7 nTPM (vital, limit 6); parathyroid gland: 45.2 nTPM (protected, limit 12); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (manageable, limit 30); smooth muscle: 39.4 nTPM (vital, limit 6); thymus: 37.5 nTPM (manageable, limit 5); kidney: 37.1 nTPM (vital, limit 6); stomach: 35.2 nTPM (protected, limit 2); thyroid gland: 35.1 nTPM (manageable, limit 5); small intestine: 33.4 nTPM (vital, limit 6); esophagus: 33.3 nTPM (protected, limit 12); adrenal gland: 32.6 nTPM (vital, limit 6); rectum: 30.9 nTPM (protected, limit 12); liver: 30.1 nTPM (vital, limit 6); pancreas: 29.2 nTPM (vital, limit 6); salivary gland: 27.3 nTPM (protected, limit 12); lymph node: 27.1 nTPM (protected, limit 2); lung: 26.7 nTPM (vital, limit 6); duodenum: 25.6 nTPM (vital, limit 6); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152102,FAM168B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.38054,-0.476468,-0.572492
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,2.5,0.5,0.7,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,ENSG00000152192,POU4F1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 81.8182% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.8182% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.2857% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 26.4706% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 69.2308% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.2857% (minimum 99%, Baseline (adaptation disabled)); thymus: 56.2500% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.0000% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,2.5,0.5,0.7,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,ENSG00000152192,POU4F1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.3875,-0.327143,-0.725294
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 81.8182% (minimum 99%, Missing); basal ganglia: 90.0000% (minimum 99%, Missing); bone marrow: 75.0000% (minimum 95%, Enhanced); cerebral cortex: 90.0000% (minimum 95%, Enhanced); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 90.0000% (minimum 99%, Missing); lymph node: 64.2857% (minimum 80%, Enhanced); midbrain: 90.0000% (minimum 99%, Missing); retina: 26.4706% (minimum 99%, Missing); skeletal muscle: 69.2308% (minimum 95%, Enhanced); spinal cord: 64.2857% (minimum 99%, Missing); thymus: 56.2500% (minimum 95%, Missing); tongue: 90.0000% (minimum 97%, Missing)",0,1,partial,2.5,0.5,0.7,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,ENSG00000152192,POU4F1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.3875,-0.157143,-0.725294
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,11.2,0.1,0,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),70,not_established,not_triggered,,,ENSG00000152208,GRID2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.7500% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.1009% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.4110% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.6606% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.4110% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.6522% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.8276% (minimum 99%, Baseline (adaptation disabled)); retina: 87.5332% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.1009% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,11.2,0.1,0,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),70,not_established,not_triggered,,,ENSG00000152208,GRID2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0269789,-0.243394
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.7500% (minimum 95%, Enhanced); amygdala: 95.1009% (minimum 99%, Missing); basal ganglia: 90.4110% (minimum 99%, Missing); cerebellum: 74.6606% (minimum 99%, Missing); cerebral cortex: 90.4110% (minimum 95%, Enhanced); hippocampal formation: 95.6522% (minimum 99%, Missing); hypothalamus: 90.9091% (minimum 99%, Missing); midbrain: 94.8276% (minimum 99%, Missing); retina: 87.5332% (minimum 99%, Missing); spinal cord: 95.1009% (minimum 99%, Missing)",0,5,partial,11.2,0.1,0,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),70,not_established,not_triggered,,,ENSG00000152208,GRID2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0269789,-0.243394
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,3.9,4.3,8.4,"thymus: 8.4 nTPM (manageable, limit 5); esophagus: 4.3 nTPM (protected, limit 2); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152253,SPC25,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 86.8421% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.4878% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.8421% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 45.8333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.0588% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.0588% (minimum 99%, Baseline (adaptation disabled)); colon: 62.2642% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.7692% (minimum 99%, Baseline (adaptation disabled)); esophagus: 43.4211% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.5714% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.4878% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 80.4878% (minimum 99%, Baseline (adaptation disabled)); lung: 78.5714% (minimum 99%, Baseline (adaptation disabled)); lymph node: 45.8333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.6154% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.7442% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.0588% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.7500% (minimum 97%, Baseline (adaptation disabled)); retina: 67.3469% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.7442% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.8421% (minimum 99%, Baseline (adaptation disabled)); skin: 76.7442% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.2642% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.1892% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.1111% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.3469% (minimum 97%, Baseline (adaptation disabled)); thymus: 28.2051% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.2857% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 86.8421% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,3.9,4.3,8.4,"thymus: 8.4 nTPM (manageable, limit 5); esophagus: 4.3 nTPM (protected, limit 2); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152253,SPC25,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.667949,-0.535789,-0.531667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 80.4878% (minimum 95%, Enhanced); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 86.8421% (minimum 99%, Missing); bone marrow: 45.8333% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 95%, Enhanced); choroid plexus: 97.0588% (minimum 99%, Missing); colon: 62.2642% (minimum 97%, Missing); duodenum: 50.7692% (minimum 99%, Missing); esophagus: 43.4211% (minimum 97%, Missing); heart muscle: 91.6667% (minimum 95%, Enhanced); hippocampal formation: 78.5714% (minimum 99%, Missing); hypothalamus: 80.4878% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 80.4878% (minimum 95%, Enhanced); lung: 78.5714% (minimum 95%, Enhanced); lymph node: 45.8333% (minimum 97%, Missing); midbrain: 84.6154% (minimum 99%, Missing); pancreas: 76.7442% (minimum 95%, Enhanced); pituitary gland: 97.0588% (minimum 99%, Missing); rectum: 68.7500% (minimum 97%, Missing); retina: 67.3469% (minimum 99%, Missing); salivary gland: 76.7442% (minimum 80%, Enhanced); skeletal muscle: 86.8421% (minimum 95%, Enhanced); skin: 76.7442% (minimum 95%, Missing); small intestine: 62.2642% (minimum 99%, Missing); smooth muscle: 78.5714% (minimum 95%, Enhanced); spinal cord: 89.1892% (minimum 99%, Missing); spleen: 61.1111% (minimum 95%, Missing); stomach: 67.3469% (minimum 97%, Missing); thymus: 28.2051% (minimum 95%, Missing)",0,2,partial,3.9,4.3,8.4,"thymus: 8.4 nTPM (manageable, limit 5); esophagus: 4.3 nTPM (protected, limit 2); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152253,SPC25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.667949,-0.535789,-0.531667
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,4.3,5.8,1.8,"parathyroid gland: 5.8 nTPM (protected, limit 4); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 2); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152315,KCNK13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.8367% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.1089% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.8367% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9011% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.3786% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.6692% (minimum 99%, Baseline (adaptation disabled)); colon: 95.7447% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.7447% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 84.9057% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.2353% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.3125% (minimum 99%, Baseline (adaptation disabled)); liver: 94.7368% (minimum 99%, Baseline (adaptation disabled)); lung: 95.7447% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.7500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7742% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.8108% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.7742% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.7368% (minimum 97%, Baseline (adaptation disabled)); small intestine: 94.7368% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.7742% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.2353% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.7500% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.7447% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 83.3333% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.7447% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,4.3,5.8,1.8,"parathyroid gland: 5.8 nTPM (protected, limit 2); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152315,KCNK13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.116667,-0.361892,-0.313308
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.8367% (minimum 98%, Approved); amygdala: 89.1089% (minimum 99%, Missing); basal ganglia: 91.8367% (minimum 99%, Missing); cerebral cortex: 87.3786% (minimum 99%, Missing); choroid plexus: 67.6692% (minimum 99%, Missing); duodenum: 95.7447% (minimum 98%, Approved); heart muscle: 84.9057% (minimum 98%, Approved); hippocampal formation: 90.0000% (minimum 99%, Missing); hypothalamus: 88.2353% (minimum 99%, Missing); kidney: 70.3125% (minimum 98%, Approved); liver: 94.7368% (minimum 98%, Approved); lung: 95.7447% (minimum 98%, Approved); lymph node: 93.7500% (minimum 95%, Approved); midbrain: 90.0000% (minimum 99%, Missing); pancreas: 96.7742% (minimum 98%, Approved); parathyroid gland: 60.8108% (minimum 95%, Approved); pituitary gland: 96.7742% (minimum 99%, Missing); rectum: 94.7368% (minimum 95%, Approved); small intestine: 94.7368% (minimum 98%, Approved); smooth muscle: 96.7742% (minimum 98%, Approved); spinal cord: 88.2353% (minimum 99%, Missing); thymus: 90.0000% (minimum 95%, Missing); thyroid gland: 83.3333% (minimum 90%, Approved)",0,0,routine_complete,4.3,5.8,1.8,"parathyroid gland: 5.8 nTPM (protected, limit 4); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 2); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152315,KCNK13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0666667,-0.341892,-0.313308
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,6.9,11.2,7.6,"parathyroid gland: 11.2 nTPM (protected, limit 4); thymus: 7.6 nTPM (manageable, limit 5); thyroid gland: 6.9 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); rectum: 5.9 nTPM (protected, limit 2); choroid plexus: 5.9 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); stomach: 4.5 nTPM (protected, limit 2); heart muscle: 4.4 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); salivary gland: 3.6 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); retina: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000152348,ATG10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.4638% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.2252% (minimum 99%, Baseline (adaptation disabled)); amygdala: 74.6269% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.7576% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.3595% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.4638% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.8931% (minimum 99%, Baseline (adaptation disabled)); colon: 65.3595% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.7576% (minimum 99%, Baseline (adaptation disabled)); esophagus: 67.5676% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.4444% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.1880% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.7576% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.9351% (minimum 99%, Baseline (adaptation disabled)); liver: 61.3497% (minimum 99%, Baseline (adaptation disabled)); lung: 73.5294% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.6269% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.9424% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.9301% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 47.1698% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.9424% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.8931% (minimum 97%, Baseline (adaptation disabled)); retina: 74.6269% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.5294% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 59.1716% (minimum 99%, Baseline (adaptation disabled)); skin: 62.1118% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.3359% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.3595% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.4444% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.4638% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.9655% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.8182% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.1716% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.9231% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.4638% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,6.9,11.2,7.6,"parathyroid gland: 11.2 nTPM (protected, limit 2); thymus: 7.6 nTPM (manageable, limit 5); thyroid gland: 6.9 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); rectum: 5.9 nTPM (protected, limit 2); choroid plexus: 5.9 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); stomach: 4.5 nTPM (protected, limit 2); heart muscle: 4.4 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); salivary gland: 3.6 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); retina: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000152348,ATG10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.381818,-0.498302,-0.398284
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.4638% (minimum 95%, Missing); adrenal gland: 66.2252% (minimum 99%, Missing); amygdala: 74.6269% (minimum 99%, Missing); basal ganglia: 75.7576% (minimum 99%, Missing); bone marrow: 65.3595% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 99%, Missing); cerebral cortex: 72.4638% (minimum 99%, Missing); choroid plexus: 62.8931% (minimum 99%, Missing); colon: 65.3595% (minimum 97%, Missing); duodenum: 75.7576% (minimum 99%, Missing); esophagus: 67.5676% (minimum 97%, Missing); heart muscle: 69.4444% (minimum 99%, Missing); hippocampal formation: 75.1880% (minimum 99%, Missing); hypothalamus: 75.7576% (minimum 99%, Missing); kidney: 64.9351% (minimum 99%, Missing); liver: 61.3497% (minimum 99%, Missing); lung: 73.5294% (minimum 99%, Missing); lymph node: 74.6269% (minimum 97%, Missing); midbrain: 71.9424% (minimum 99%, Missing); pancreas: 69.9301% (minimum 99%, Missing); parathyroid gland: 47.1698% (minimum 95%, Approved); pituitary gland: 71.9424% (minimum 99%, Missing); rectum: 62.8931% (minimum 97%, Missing); retina: 74.6269% (minimum 99%, Missing); salivary gland: 73.5294% (minimum 97%, Missing); skeletal muscle: 59.1716% (minimum 99%, Missing); skin: 62.1118% (minimum 95%, Missing); small intestine: 76.3359% (minimum 99%, Missing); smooth muscle: 65.3595% (minimum 99%, Missing); spinal cord: 69.4444% (minimum 99%, Missing); spleen: 72.4638% (minimum 95%, Missing); stomach: 68.9655% (minimum 97%, Missing); thymus: 56.8182% (minimum 95%, Missing); thyroid gland: 59.1716% (minimum 95%, Missing); tongue: 76.9231% (minimum 97%, Missing); urinary bladder: 72.4638% (minimum 97%, Missing)",0,3,partial,6.9,11.2,7.6,"parathyroid gland: 11.2 nTPM (protected, limit 4); thymus: 7.6 nTPM (manageable, limit 5); thyroid gland: 6.9 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); rectum: 5.9 nTPM (protected, limit 2); choroid plexus: 5.9 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); stomach: 4.5 nTPM (protected, limit 2); heart muscle: 4.4 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); salivary gland: 3.6 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); retina: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000152348,ATG10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.381818,-0.478302,-0.398284
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,11.4,11.1,9.9,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); colon: 10.5 nTPM (protected, limit 2); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); smooth muscle: 7 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); thymus: 5.4 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000152409,JMY,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.8814% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.8824% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.8442% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.9268% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.1875% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.6250% (minimum 99%, Baseline (adaptation disabled)); colon: 55.1282% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.6250% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.8814% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.8814% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.4386% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.5393% (minimum 99%, Baseline (adaptation disabled)); liver: 71.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 77.2455% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.8824% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.6364% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 53.7500% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.2955% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.4386% (minimum 97%, Baseline (adaptation disabled)); retina: 53.0864% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.1791% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 66.4948% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.8241% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.8814% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.8814% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.0670% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.4918% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.5789% (minimum 95%, Baseline (adaptation disabled)); tongue: 63.5468% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.9840% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,11.4,11.1,9.9,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); colon: 10.5 nTPM (protected, limit 2); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); smooth muscle: 7 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); thymus: 5.4 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000152409,JMY,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.384211,-0.4325,-0.459136
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Uncertain); adrenal gland: 72.8814% (minimum 99%, Missing); amygdala: 75.8824% (minimum 99%, Missing); basal ganglia: 71.6667% (minimum 99%, Missing); bone marrow: 55.8442% (minimum 99%, Missing); cerebellum: 62.9268% (minimum 99%, Missing); cerebral cortex: 67.1875% (minimum 99%, Missing); choroid plexus: 80.6250% (minimum 99%, Missing); colon: 55.1282% (minimum 97%, Missing); duodenum: 80.6250% (minimum 99%, Missing); esophagus: 72.8814% (minimum 97%, Missing); heart muscle: 72.8814% (minimum 99%, Missing); hippocampal formation: 75.4386% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 67.5393% (minimum 99%, Missing); liver: 71.6667% (minimum 99%, Missing); lung: 77.2455% (minimum 99%, Missing); lymph node: 75.8824% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 58.6364% (minimum 99%, Missing); parathyroid gland: 53.7500% (minimum 97%, Missing); pituitary gland: 73.2955% (minimum 99%, Missing); rectum: 75.4386% (minimum 97%, Missing); retina: 53.0864% (minimum 99%, Missing); salivary gland: 64.1791% (minimum 97%, Missing); skeletal muscle: 60.0000% (minimum 99%, Missing); skin: 66.4948% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 64.8241% (minimum 99%, Missing); spinal cord: 72.8814% (minimum 99%, Missing); spleen: 72.8814% (minimum 95%, Missing); stomach: 72.0670% (minimum 97%, Missing); thymus: 70.4918% (minimum 95%, Missing); thyroid gland: 56.5789% (minimum 95%, Missing); tongue: 63.5468% (minimum 97%, Missing); urinary bladder: 68.9840% (minimum 97%, Missing)",0,2,partial,11.4,11.1,9.9,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); colon: 10.5 nTPM (protected, limit 2); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); salivary gland: 7.2 nTPM (protected, limit 2); smooth muscle: 7 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 2); thymus: 5.4 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 2); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000152409,JMY,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.384211,-0.4325,-0.459136
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,7.7,8.3,10,"thymus: 10 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 2); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 3); urinary bladder: 5.3 nTPM (protected, limit 2); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); adrenal gland: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 3); esophagus: 3.7 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152422,XRCC4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.4062% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.4603% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.2479% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.9291% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.8915% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.1584% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.0339% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 59.8592% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.7975% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.6721% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.4691% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.5484% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.2759% (minimum 99%, Baseline (adaptation disabled)); kidney: 54.8387% (minimum 99%, Baseline (adaptation disabled)); liver: 61.5942% (minimum 99%, Baseline (adaptation disabled)); lung: 65.3846% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.5952% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.9817% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.9817% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.1887% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.7143% (minimum 97%, Baseline (adaptation disabled)); retina: 78.7037% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.0339% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.2727% (minimum 99%, Baseline (adaptation disabled)); skin: 72.6496% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.9630% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.6721% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.3939% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.9291% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.9459% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.9291% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.7037% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.5942% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,7.7,8.3,10,"thymus: 10 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 2); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 2); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); adrenal gland: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152422,XRCC4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.490541,-0.464048,-0.465309
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.4062% (minimum 95%, Missing); adrenal gland: 67.4603% (minimum 99%, Missing); amygdala: 70.2479% (minimum 99%, Missing); basal ganglia: 66.9291% (minimum 99%, Missing); bone marrow: 65.8915% (minimum 99%, Missing); cerebellum: 84.1584% (minimum 99%, Missing); cerebral cortex: 72.0339% (minimum 99%, Missing); choroid plexus: 85.0000% (minimum 99%, Missing); colon: 59.8592% (minimum 97%, Missing); duodenum: 53.7975% (minimum 99%, Missing); esophagus: 69.6721% (minimum 97%, Missing); heart muscle: 52.4691% (minimum 99%, Missing); hippocampal formation: 68.5484% (minimum 99%, Missing); hypothalamus: 73.2759% (minimum 99%, Missing); kidney: 54.8387% (minimum 99%, Missing); liver: 61.5942% (minimum 97%, Supported); lung: 65.3846% (minimum 99%, Missing); lymph node: 50.5952% (minimum 97%, Missing); midbrain: 68.0000% (minimum 99%, Missing); pancreas: 77.9817% (minimum 99%, Missing); parathyroid gland: 77.9817% (minimum 97%, Missing); pituitary gland: 80.1887% (minimum 99%, Missing); rectum: 60.7143% (minimum 97%, Missing); retina: 78.7037% (minimum 99%, Missing); salivary gland: 72.0339% (minimum 97%, Missing); skeletal muscle: 77.2727% (minimum 99%, Missing); skin: 72.6496% (minimum 95%, Missing); small intestine: 62.9630% (minimum 99%, Missing); smooth muscle: 69.6721% (minimum 97%, Supported); spinal cord: 68.0000% (minimum 99%, Missing); spleen: 64.3939% (minimum 95%, Missing); stomach: 66.9291% (minimum 97%, Missing); thymus: 45.9459% (minimum 95%, Missing); thyroid gland: 66.9291% (minimum 95%, Missing); tongue: 78.7037% (minimum 97%, Missing); urinary bladder: 61.5942% (minimum 97%, Missing)",0,6,partial,7.7,8.3,10,"thymus: 10 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 2); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 3); urinary bladder: 5.3 nTPM (protected, limit 2); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); adrenal gland: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 3); esophagus: 3.7 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152422,XRCC4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.490541,-0.464048,-0.465309
True,compatible,,True,True,False,,0,1,partial,3.6,1.3,0,,,54,not_established,not_triggered,,,ENSG00000152430,BOLL,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 92.9550% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,3.6,1.3,0,"skeletal muscle: 3.6 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,ENSG00000152430,BOLL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.00336066,-0.0604501
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 92.9550% (minimum 95%, Enhanced)",0,1,partial,3.6,1.3,0,,,54,not_established,not_triggered,,,ENSG00000152430,BOLL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.00336066,-0.0204501
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,20,10.5,12.3,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); thymus: 12.3 nTPM (manageable, limit 5); parathyroid gland: 10.5 nTPM (protected, limit 2); tongue: 9.9 nTPM (protected, limit 2); thyroid gland: 9 nTPM (manageable, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 2); pituitary gland: 8 nTPM (vital, limit 1); spleen: 7.9 nTPM (manageable, limit 5); salivary gland: 7.6 nTPM (protected, limit 2); kidney: 7.4 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 2); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); midbrain: 5.1 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152443,ZNF776,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.3992% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 77.0073% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.3233% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.1481% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.5263% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 59.7734% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.0073% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.8598% (minimum 99%, Baseline (adaptation disabled)); colon: 77.2894% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.2894% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.1538% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.3571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.7313% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.4387% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.0351% (minimum 99%, Baseline (adaptation disabled)); liver: 76.1733% (minimum 99%, Baseline (adaptation disabled)); lung: 77.5735% (minimum 99%, Baseline (adaptation disabled)); lymph node: 72.2603% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.5344% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.4219% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.7722% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.5086% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.4493% (minimum 97%, Baseline (adaptation disabled)); retina: 51.3382% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.5192% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 70.5686% (minimum 99%, Baseline (adaptation disabled)); skin: 77.0073% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.4387% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.0637% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.4387% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.7586% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.0351% (minimum 97%, Baseline (adaptation disabled)); thymus: 63.1737% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.0997% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.0645% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 79.6226% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,20,10.5,12.3,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); thymus: 12.3 nTPM (manageable, limit 5); parathyroid gland: 10.5 nTPM (protected, limit 2); tongue: 9.9 nTPM (protected, limit 2); thyroid gland: 9 nTPM (manageable, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 2); pituitary gland: 8 nTPM (vital, limit 1); spleen: 7.9 nTPM (manageable, limit 5); salivary gland: 7.6 nTPM (protected, limit 2); kidney: 7.4 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 2); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); midbrain: 5.1 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152443,ZNF776,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.318263,-0.302278,-0.476618
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.3992% (minimum 95%, Missing); adrenal gland: 77.0073% (minimum 99%, Missing); amygdala: 79.3233% (minimum 99%, Missing); basal ganglia: 78.1481% (minimum 99%, Missing); bone marrow: 55.5263% (minimum 99%, Missing); cerebellum: 59.7734% (minimum 99%, Missing); cerebral cortex: 77.0073% (minimum 99%, Missing); choroid plexus: 77.8598% (minimum 99%, Missing); colon: 77.2894% (minimum 97%, Missing); duodenum: 77.2894% (minimum 99%, Missing); esophagus: 81.1538% (minimum 97%, Missing); heart muscle: 75.3571% (minimum 99%, Missing); hippocampal formation: 78.7313% (minimum 99%, Missing); hypothalamus: 78.4387% (minimum 99%, Missing); kidney: 74.0351% (minimum 99%, Missing); liver: 76.1733% (minimum 99%, Missing); lung: 77.5735% (minimum 99%, Missing); lymph node: 72.2603% (minimum 97%, Missing); midbrain: 80.5344% (minimum 99%, Missing); pancreas: 82.4219% (minimum 99%, Missing); parathyroid gland: 66.7722% (minimum 97%, Missing); pituitary gland: 72.5086% (minimum 99%, Missing); rectum: 76.4493% (minimum 97%, Missing); retina: 51.3382% (minimum 99%, Missing); salivary gland: 73.5192% (minimum 97%, Missing); skeletal muscle: 70.5686% (minimum 99%, Missing); skin: 77.0073% (minimum 95%, Missing); small intestine: 78.4387% (minimum 99%, Missing); smooth muscle: 84.0637% (minimum 99%, Missing); spinal cord: 78.4387% (minimum 99%, Missing); spleen: 72.7586% (minimum 95%, Missing); stomach: 74.0351% (minimum 97%, Missing); thymus: 63.1737% (minimum 95%, Missing); thyroid gland: 70.0997% (minimum 95%, Missing); tongue: 68.0645% (minimum 97%, Missing); urinary bladder: 79.6226% (minimum 97%, Missing)",0,80,unavailable,20,10.5,12.3,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); thymus: 12.3 nTPM (manageable, limit 5); parathyroid gland: 10.5 nTPM (protected, limit 2); tongue: 9.9 nTPM (protected, limit 2); thyroid gland: 9 nTPM (manageable, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 2); pituitary gland: 8 nTPM (vital, limit 1); spleen: 7.9 nTPM (manageable, limit 5); salivary gland: 7.6 nTPM (protected, limit 2); kidney: 7.4 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 2); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 2); skin: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); midbrain: 5.1 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 2); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152443,ZNF776,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.318263,-0.302278,-0.476618
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,4.9,3.3,5.9,"thymus: 5.9 nTPM (manageable, limit 5); retina: 3.3 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152455,SUV39H2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7761% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.4557% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.4887% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.9698% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.6047% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.2121% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.9698% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9610% (minimum 99%, Baseline (adaptation disabled)); colon: 92.9268% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.0125% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.4757% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.4425% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.4557% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.7005% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.0741% (minimum 99%, Baseline (adaptation disabled)); liver: 92.7007% (minimum 99%, Baseline (adaptation disabled)); lung: 96.7005% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.8424% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.7286% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.5409% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.4887% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.7005% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.0290% (minimum 97%, Baseline (adaptation disabled)); retina: 92.0290% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.7286% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.7005% (minimum 99%, Baseline (adaptation disabled)); small intestine: 93.8424% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.3069% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.2121% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.2500% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.5909% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.9466% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.7007% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,4.9,3.3,5.9,"thymus: 5.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); esophagus: 3.1 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152455,SUV39H2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0840909,-0.0497101,-0.103953
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.4887% (minimum 99%, Missing); basal ganglia: 95.9698% (minimum 99%, Missing); bone marrow: 88.6047% (minimum 95%, Enhanced); choroid plexus: 98.9610% (minimum 99%, Missing); hippocampal formation: 96.4557% (minimum 99%, Missing); hypothalamus: 96.7005% (minimum 99%, Missing); kidney: 94.0741% (minimum 95%, Enhanced); liver: 92.7007% (minimum 95%, Enhanced); midbrain: 95.7286% (minimum 99%, Missing); pancreas: 94.5409% (minimum 95%, Enhanced); pituitary gland: 96.7005% (minimum 99%, Missing); retina: 92.0290% (minimum 99%, Missing); small intestine: 93.8424% (minimum 95%, Enhanced); smooth muscle: 94.3069% (minimum 95%, Enhanced); spinal cord: 96.2121% (minimum 99%, Missing); thymus: 86.5909% (minimum 95%, Missing); tongue: 96.9466% (minimum 97%, Missing)",0,1,partial,4.9,3.3,5.9,"thymus: 5.9 nTPM (manageable, limit 5); retina: 3.3 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152455,SUV39H2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0840909,-0.000534351,-0.0697101
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,1.7,2.9,8.7,"salivary gland: 2.6 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus,ENSG00000152463,OLAH,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.5652% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.4906% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.1203% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.9559% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.4906% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.3881% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.0000% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 98.4906% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8636% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.9559% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8636% (minimum 99%, Baseline (adaptation disabled)); lung: 93.8849% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.1203% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.3100% (minimum 99%, Baseline (adaptation disabled)); retina: 97.3881% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.9408% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.1203% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,1.7,2.9,8.7,"spleen: 8.7 nTPM (manageable, limit 5); esophagus: 2.9 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus,ENSG00000152463,OLAH,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.2,-0.07,-0.0511511
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.6667% (minimum 99%, Missing); amygdala: 98.4906% (minimum 99%, Missing); basal ganglia: 98.1203% (minimum 99%, Missing); choroid plexus: 97.3881% (minimum 99%, Missing); hippocampal formation: 98.4906% (minimum 99%, Missing); hypothalamus: 98.8636% (minimum 99%, Missing); lung: 93.8849% (minimum 95%, Enhanced); midbrain: 98.1203% (minimum 99%, Missing); pituitary gland: 96.3100% (minimum 99%, Missing); retina: 97.3881% (minimum 99%, Missing); salivary gland: 90.9408% (minimum 97%, Missing)",0,3,partial,1.7,2.9,8.7,"salivary gland: 2.6 nTPM (protected, limit 2)",adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus,ENSG00000152463,OLAH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0461832,-0.0605923,-0.0269004
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,21.5,19.6,17.2,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 2); liver: 18.9 nTPM (vital, limit 2); skeletal muscle: 18.3 nTPM (vital, limit 2); spleen: 17.2 nTPM (manageable, limit 10); urinary bladder: 17 nTPM (protected, limit 2); choroid plexus: 17 nTPM (vital, limit 1); kidney: 16.7 nTPM (vital, limit 1); skin: 16.7 nTPM (manageable, limit 5); small intestine: 16.1 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 2); esophagus: 15.8 nTPM (protected, limit 2); colon: 15.8 nTPM (protected, limit 2); thyroid gland: 15.7 nTPM (manageable, limit 10); duodenum: 15.4 nTPM (vital, limit 1); thymus: 15.3 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); pancreas: 14.8 nTPM (vital, limit 2); tongue: 14.3 nTPM (protected, limit 2); salivary gland: 14 nTPM (protected, limit 2); parathyroid gland: 13.8 nTPM (protected, limit 4); adipose tissue: 13.5 nTPM (manageable, limit 10); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); bone marrow: 12.3 nTPM (vital, limit 2); smooth muscle: 12 nTPM (vital, limit 2); basal ganglia: 11 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152464,RPP38,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.5748% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.8851% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.3929% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.9359% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.1525% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.4751% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.2183% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.3124% (minimum 99%, Baseline (adaptation disabled)); colon: 74.7200% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.2013% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.7200% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 78.7521% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.6549% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.0738% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.6593% (minimum 99%, Baseline (adaptation disabled)); liver: 71.1890% (minimum 99%, Baseline (adaptation disabled)); lung: 77.8333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.4374% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.2183% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.9350% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.1901% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.0936% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.3631% (minimum 97%, Baseline (adaptation disabled)); retina: 78.2245% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.9357% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.8462% (minimum 99%, Baseline (adaptation disabled)); skin: 73.6593% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.3631% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 79.5571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.2183% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.0829% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.6888% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.3226% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 74.8397% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.5574% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.3124% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,21.5,19.6,17.2,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 2); liver: 18.9 nTPM (vital, limit 1); skeletal muscle: 18.3 nTPM (vital, limit 1); spleen: 17.2 nTPM (manageable, limit 5); urinary bladder: 17 nTPM (protected, limit 2); choroid plexus: 17 nTPM (vital, limit 1); kidney: 16.7 nTPM (vital, limit 1); skin: 16.7 nTPM (manageable, limit 5); small intestine: 16.1 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 2); esophagus: 15.8 nTPM (protected, limit 2); colon: 15.8 nTPM (protected, limit 2); thyroid gland: 15.7 nTPM (manageable, limit 5); duodenum: 15.4 nTPM (vital, limit 1); thymus: 15.3 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); pancreas: 14.8 nTPM (vital, limit 1); tongue: 14.3 nTPM (protected, limit 2); salivary gland: 14 nTPM (protected, limit 2); parathyroid gland: 13.8 nTPM (protected, limit 2); adipose tissue: 13.5 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); bone marrow: 12.3 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152464,RPP38,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.219171,-0.265626,-0.305249
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.5748% (minimum 90%, Approved); adrenal gland: 78.8851% (minimum 98%, Approved); amygdala: 83.3929% (minimum 99%, Missing); basal ganglia: 80.9359% (minimum 99%, Missing); bone marrow: 79.1525% (minimum 98%, Approved); cerebellum: 68.4751% (minimum 99%, Missing); cerebral cortex: 82.2183% (minimum 99%, Missing); choroid plexus: 73.3124% (minimum 99%, Missing); colon: 74.7200% (minimum 97%, Missing); duodenum: 75.2013% (minimum 99%, Missing); esophagus: 74.7200% (minimum 97%, Missing); heart muscle: 78.7521% (minimum 99%, Missing); hippocampal formation: 82.6549% (minimum 99%, Missing); hypothalamus: 82.0738% (minimum 99%, Missing); kidney: 73.6593% (minimum 99%, Missing); liver: 71.1890% (minimum 98%, Approved); lung: 77.8333% (minimum 99%, Missing); lymph node: 70.4374% (minimum 97%, Missing); midbrain: 82.2183% (minimum 99%, Missing); pancreas: 75.9350% (minimum 98%, Approved); parathyroid gland: 77.1901% (minimum 95%, Approved); pituitary gland: 78.0936% (minimum 99%, Missing); rectum: 74.3631% (minimum 97%, Missing); retina: 78.2245% (minimum 99%, Missing); salivary gland: 76.9357% (minimum 97%, Missing); skeletal muscle: 71.8462% (minimum 98%, Approved); skin: 73.6593% (minimum 95%, Missing); small intestine: 74.3631% (minimum 99%, Missing); smooth muscle: 79.5571% (minimum 98%, Approved); spinal cord: 82.2183% (minimum 99%, Missing); spleen: 73.0829% (minimum 90%, Approved); stomach: 75.6888% (minimum 97%, Missing); thymus: 75.3226% (minimum 95%, Missing); thyroid gland: 74.8397% (minimum 90%, Approved); tongue: 76.5574% (minimum 97%, Missing); urinary bladder: 73.3124% (minimum 97%, Missing)",0,3,partial,21.5,19.6,17.2,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 2); liver: 18.9 nTPM (vital, limit 2); skeletal muscle: 18.3 nTPM (vital, limit 2); spleen: 17.2 nTPM (manageable, limit 10); urinary bladder: 17 nTPM (protected, limit 2); choroid plexus: 17 nTPM (vital, limit 1); kidney: 16.7 nTPM (vital, limit 1); skin: 16.7 nTPM (manageable, limit 5); small intestine: 16.1 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 2); esophagus: 15.8 nTPM (protected, limit 2); colon: 15.8 nTPM (protected, limit 2); thyroid gland: 15.7 nTPM (manageable, limit 10); duodenum: 15.4 nTPM (vital, limit 1); thymus: 15.3 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 2); pancreas: 14.8 nTPM (vital, limit 2); tongue: 14.3 nTPM (protected, limit 2); salivary gland: 14 nTPM (protected, limit 2); parathyroid gland: 13.8 nTPM (protected, limit 4); adipose tissue: 13.5 nTPM (manageable, limit 10); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); bone marrow: 12.3 nTPM (vital, limit 2); smooth muscle: 12 nTPM (vital, limit 2); basal ganglia: 11 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152464,RPP38,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.213407,-0.265626,-0.305249
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,53.5,7.9,54,"thymus: 54 nTPM (manageable, limit 5); cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000152495,CAMK4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.0937% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.7586% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 34.7328% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 74.5902% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 14.5367% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 47.8947% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.8495% (minimum 99%, Baseline (adaptation disabled)); colon: 87.5000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.5000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.8571% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.9130% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.5390% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.2066% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.8144% (minimum 99%, Baseline (adaptation disabled)); liver: 86.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 90.0990% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.5294% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.8085% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.8144% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 66.4234% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.7895% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.9130% (minimum 99%, Baseline (adaptation disabled)); small intestine: 79.8246% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.9192% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.0467% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.7778% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.8491% (minimum 97%, Baseline (adaptation disabled)); thymus: 14.4216% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 84.2593% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,53.5,7.9,54,"thymus: 54 nTPM (manageable, limit 5); cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000152495,CAMK4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.805784,-0.434706,-0.844633
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.0937% (minimum 99%, Missing); amygdala: 62.7586% (minimum 99%, Missing); basal ganglia: 34.7328% (minimum 99%, Missing); bone marrow: 74.5902% (minimum 99%, Missing); cerebellum: 14.5367% (minimum 99%, Missing); cerebral cortex: 47.8947% (minimum 99%, Missing); choroid plexus: 97.8495% (minimum 99%, Missing); colon: 87.5000% (minimum 97%, Missing); duodenum: 87.5000% (minimum 99%, Missing); esophagus: 92.8571% (minimum 95%, Approved); hippocampal formation: 64.5390% (minimum 99%, Missing); hypothalamus: 75.2066% (minimum 99%, Missing); kidney: 93.8144% (minimum 99%, Missing); liver: 86.6667% (minimum 99%, Missing); lung: 90.0990% (minimum 99%, Missing); lymph node: 53.5294% (minimum 97%, Missing); midbrain: 86.6667% (minimum 99%, Missing); pancreas: 96.8085% (minimum 98%, Approved); pituitary gland: 93.8144% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 66.4234% (minimum 99%, Missing); small intestine: 79.8246% (minimum 99%, Missing); smooth muscle: 91.9192% (minimum 98%, Approved); spinal cord: 85.0467% (minimum 99%, Missing); spleen: 77.7778% (minimum 90%, Approved); stomach: 85.8491% (minimum 97%, Missing); thymus: 14.4216% (minimum 95%, Missing); urinary bladder: 84.2593% (minimum 97%, Missing)",0,1,partial,53.5,7.9,54,"thymus: 54 nTPM (manageable, limit 5); cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000152495,CAMK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.805784,-0.434706,-0.844633
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,42.9,7.3,0.7,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152503,TRIM36,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 93.9478% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2973% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.4595% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.1569% (minimum 99%, Baseline (adaptation disabled)); colon: 95.9184% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.5096% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.8650% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.8140% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.2745% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.8650% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.8640% (minimum 97%, Baseline (adaptation disabled)); retina: 79.7737% (minimum 99%, Baseline (adaptation disabled)); small intestine: 92.6616% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.9677% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,42.9,7.3,0.7,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152503,TRIM36,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0458799,-0.0113598,-0.192263
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 93.9478% (minimum 99%, Missing); basal ganglia: 97.2973% (minimum 99%, Missing); cerebral cortex: 91.4595% (minimum 99%, Missing); choroid plexus: 92.1569% (minimum 99%, Missing); colon: 95.9184% (minimum 97%, Missing); duodenum: 92.5096% (minimum 99%, Missing); hippocampal formation: 92.8650% (minimum 99%, Missing); hypothalamus: 92.8140% (minimum 99%, Missing); midbrain: 93.2745% (minimum 99%, Missing); pituitary gland: 92.8650% (minimum 99%, Missing); rectum: 95.8640% (minimum 97%, Missing); retina: 79.7737% (minimum 99%, Missing); small intestine: 92.6616% (minimum 99%, Missing); spinal cord: 90.9677% (minimum 99%, Missing)",0,80,unavailable,42.9,7.3,0.7,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152503,TRIM36,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0458799,-0.0113598,-0.192263
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,18.5,8.3,8.4,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); kidney: 7.4 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152582,SPEF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.0714% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.9524% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.9551% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.6168% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.4393% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.7426% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 45.2663% (minimum 99%, Baseline (adaptation disabled)); colon: 89.4737% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.4444% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.8650% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.4737% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.8660% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.4009% (minimum 99%, Baseline (adaptation disabled)); liver: 91.6168% (minimum 99%, Baseline (adaptation disabled)); lung: 77.6650% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.5325% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.0612% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.8305% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.8333% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.9535% (minimum 97%, Baseline (adaptation disabled)); retina: 60.7143% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.7027% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.4522% (minimum 99%, Baseline (adaptation disabled)); skin: 92.7273% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.0714% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.8660% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.9318% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.4286% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.4393% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.5570% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.8354% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.9318% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,18.5,8.3,8.4,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); thyroid gland: 8.4 nTPM (manageable, limit 5); parathyroid gland: 8.3 nTPM (protected, limit 2); kidney: 7.4 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); cerebellum: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152582,SPEF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.30443,-0.321695,-0.537337
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 80.9524% (minimum 95%, Enhanced); amygdala: 85.9551% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 91.6168% (minimum 95%, Enhanced); cerebellum: 88.4393% (minimum 95%, Enhanced); cerebral cortex: 75.7426% (minimum 95%, Enhanced); choroid plexus: 45.2663% (minimum 99%, Missing); duodenum: 94.4444% (minimum 95%, Enhanced); heart muscle: 89.4737% (minimum 95%, Enhanced); hippocampal formation: 85.0000% (minimum 99%, Missing); hypothalamus: 78.8660% (minimum 99%, Missing); kidney: 67.4009% (minimum 95%, Enhanced); liver: 91.6168% (minimum 95%, Enhanced); lung: 77.6650% (minimum 95%, Enhanced); midbrain: 90.0000% (minimum 99%, Missing); pancreas: 78.0612% (minimum 95%, Enhanced); parathyroid gland: 64.8305% (minimum 80%, Enhanced); pituitary gland: 70.8333% (minimum 99%, Missing); retina: 60.7143% (minimum 99%, Missing); small intestine: 91.0714% (minimum 95%, Enhanced); smooth muscle: 78.8660% (minimum 95%, Enhanced); spinal cord: 90.0000% (minimum 99%, Missing); thymus: 88.4393% (minimum 95%, Missing); tongue: 96.8354% (minimum 97%, Missing)",0,4,partial,18.5,8.3,8.4,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); kidney: 7.4 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152582,SPEF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0656069,-0.151695,-0.537337
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,0,0.1,0,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152592,DMP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"urinary bladder: 88.8889% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,0,0.1,0,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152592,DMP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,-0.0811111,0.01
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"urinary bladder: 88.8889% (minimum 97%, Missing)",0,4,partial,0,0.1,0,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000152592,DMP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,-0.0811111,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,88.5,1.1,6.5,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); hippocampal formation: 7.1 nTPM (vital, limit 1); thymus: 6.5 nTPM (manageable, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000152611,CAPSL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.0573% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.6161% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 54.7777% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.7883% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.5428% (minimum 99%, Baseline (adaptation disabled)); lung: 93.5428% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.5294% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 89.0365% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5294% (minimum 99%, Baseline (adaptation disabled)); thymus: 94.2832% (minimum 95%, Baseline (adaptation disabled))",0,5,partial,88.5,1.1,6.5,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); thymus: 6.5 nTPM (manageable, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000152611,CAPSL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.00716799,0.019843,-0.442223
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.0573% (minimum 99%, Missing); basal ganglia: 94.6161% (minimum 99%, Missing); choroid plexus: 54.7777% (minimum 99%, Missing); hippocampal formation: 93.7883% (minimum 99%, Missing); hypothalamus: 93.5428% (minimum 99%, Missing); lung: 93.5428% (minimum 95%, Enhanced); midbrain: 98.5294% (minimum 99%, Missing); pituitary gland: 89.0365% (minimum 99%, Missing); spinal cord: 98.5294% (minimum 99%, Missing); thymus: 94.2832% (minimum 95%, Missing)",0,5,partial,88.5,1.1,6.5,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); hippocampal formation: 7.1 nTPM (vital, limit 1); thymus: 6.5 nTPM (manageable, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000152611,CAPSL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.00716799,0.03,-0.442223
True,compatible,,True,True,False,,0,1,partial,0.4,0.2,0.2,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,ENSG00000152670,DDX4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.4,0.2,0.2,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,ENSG00000152670,DDX4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0486245,0.0286245,0.00725275
True,compatible,,True,True,True,,0,1,partial,0.4,0.2,0.2,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,ENSG00000152670,DDX4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0486245,0.03,0.00793814
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,1.7,0.7,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152705,CATSPER3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.2973% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.9592% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2973% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.9592% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2935% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.9592% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.6811% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.9592% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.6271% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2935% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.6271% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.7368% (minimum 99%, Baseline (adaptation disabled)); liver: 94.4262% (minimum 99%, Baseline (adaptation disabled)); lung: 98.6301% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.6271% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.6811% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.2973% (minimum 99%, Baseline (adaptation disabled)); retina: 91.7197% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 90.8517% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.6271% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.9592% (minimum 99%, Baseline (adaptation disabled)); tongue: 94.4262% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,1.7,0.7,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152705,CATSPER3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0262712,-0.0257377,-0.0814826
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.2973% (minimum 99%, Missing); amygdala: 97.9592% (minimum 99%, Missing); basal ganglia: 97.2973% (minimum 99%, Missing); bone marrow: 97.9592% (minimum 99%, Missing); cerebellum: 98.2935% (minimum 99%, Missing); cerebral cortex: 97.9592% (minimum 99%, Missing); choroid plexus: 95.6811% (minimum 99%, Missing); duodenum: 97.9592% (minimum 99%, Missing); heart muscle: 97.6271% (minimum 99%, Missing); hippocampal formation: 98.2935% (minimum 99%, Missing); hypothalamus: 97.6271% (minimum 99%, Missing); kidney: 94.7368% (minimum 99%, Missing); liver: 94.4262% (minimum 99%, Missing); lung: 98.6301% (minimum 99%, Missing); midbrain: 97.6271% (minimum 99%, Missing); pancreas: 95.6811% (minimum 99%, Missing); pituitary gland: 97.2973% (minimum 99%, Missing); retina: 91.7197% (minimum 99%, Missing); skeletal muscle: 90.8517% (minimum 99%, Missing); small intestine: 97.6271% (minimum 99%, Missing); spinal cord: 97.9592% (minimum 99%, Missing); tongue: 94.4262% (minimum 97%, Missing)",0,80,unavailable,2.9,1.7,0.7,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152705,CATSPER3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0262712,-0.0257377,-0.0814826
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,20,6.7,5.7,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 2); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); colon: 5.2 nTPM (protected, limit 2); lung: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152763,DNAI4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5307% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.7368% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.9348% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.8439% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.6102% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.0996% (minimum 99%, Baseline (adaptation disabled)); colon: 86.8020% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.9943% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.8839% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.9348% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.9355% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.8635% (minimum 99%, Baseline (adaptation disabled)); liver: 96.6102% (minimum 99%, Baseline (adaptation disabled)); lung: 89.2950% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.7983% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.0674% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.6186% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.6829% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.5288% (minimum 97%, Baseline (adaptation disabled)); retina: 89.7638% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.5591% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2759% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.3380% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.5307% (minimum 99%, Baseline (adaptation disabled)); thymus: 93.9560% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.7143% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,20,6.7,5.7,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 2); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); colon: 5.2 nTPM (protected, limit 2); lung: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152763,DNAI4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0928571,-0.133814,-0.359004
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5307% (minimum 99%, Missing); amygdala: 94.7368% (minimum 99%, Missing); basal ganglia: 92.9348% (minimum 99%, Missing); cerebellum: 98.8439% (minimum 99%, Missing); cerebral cortex: 96.6102% (minimum 99%, Missing); choroid plexus: 63.0996% (minimum 99%, Missing); colon: 86.8020% (minimum 97%, Missing); duodenum: 97.9943% (minimum 99%, Missing); heart muscle: 96.8839% (minimum 99%, Missing); hippocampal formation: 92.9348% (minimum 99%, Missing); hypothalamus: 91.9355% (minimum 99%, Missing); kidney: 84.8635% (minimum 99%, Missing); liver: 96.6102% (minimum 99%, Missing); lung: 89.2950% (minimum 99%, Missing); midbrain: 95.7983% (minimum 99%, Missing); pancreas: 96.0674% (minimum 99%, Missing); parathyroid gland: 83.6186% (minimum 97%, Missing); pituitary gland: 92.6829% (minimum 99%, Missing); rectum: 89.5288% (minimum 97%, Missing); retina: 89.7638% (minimum 99%, Missing); skeletal muscle: 98.5591% (minimum 99%, Missing); small intestine: 98.2759% (minimum 99%, Missing); smooth muscle: 96.3380% (minimum 99%, Missing); spinal cord: 95.5307% (minimum 99%, Missing); thymus: 93.9560% (minimum 95%, Missing); thyroid gland: 85.7143% (minimum 95%, Missing)",0,80,unavailable,20,6.7,5.7,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 2); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); colon: 5.2 nTPM (protected, limit 2); lung: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000152763,DNAI4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0928571,-0.133814,-0.359004
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,33.2,17.3,18,"bone marrow: 33.2 nTPM (vital, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 17.3 nTPM (protected, limit 2); skin: 8.9 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 2); esophagus: 7.3 nTPM (protected, limit 2); colon: 7.1 nTPM (protected, limit 2); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); heart muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000153044,CENPH,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.8049% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.8111% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.0128% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.1392% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 46.4516% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.4262% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.9032% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.9592% (minimum 99%, Baseline (adaptation disabled)); colon: 80.2228% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.8182% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.7784% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.3436% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.9032% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.5065% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.0495% (minimum 99%, Baseline (adaptation disabled)); liver: 89.1641% (minimum 99%, Baseline (adaptation disabled)); lung: 91.4286% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.4729% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.0128% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.0495% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.8111% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.3642% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.6885% (minimum 97%, Baseline (adaptation disabled)); retina: 92.3077% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.1392% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.0734% (minimum 99%, Baseline (adaptation disabled)); skin: 76.3926% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.4783% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.0128% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.2071% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.8889% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.5385% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.3077% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.3436% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.6154% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,33.2,17.3,18,"bone marrow: 33.2 nTPM (vital, limit 1); thymus: 18 nTPM (manageable, limit 5); lymph node: 17.3 nTPM (protected, limit 2); skin: 8.9 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 2); esophagus: 7.3 nTPM (protected, limit 2); colon: 7.1 nTPM (protected, limit 2); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); heart muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000153044,CENPH,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.334615,-0.345271,-0.525484
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.8049% (minimum 90%, Approved); adrenal gland: 93.8111% (minimum 99%, Missing); amygdala: 92.0128% (minimum 99%, Missing); basal ganglia: 91.1392% (minimum 99%, Missing); bone marrow: 46.4516% (minimum 98%, Approved); cerebellum: 94.4262% (minimum 99%, Missing); cerebral cortex: 92.9032% (minimum 99%, Missing); choroid plexus: 97.9592% (minimum 99%, Missing); colon: 80.2228% (minimum 97%, Missing); duodenum: 81.8182% (minimum 99%, Missing); esophagus: 79.7784% (minimum 97%, Missing); heart muscle: 88.3436% (minimum 99%, Missing); hippocampal formation: 92.9032% (minimum 99%, Missing); hypothalamus: 93.5065% (minimum 99%, Missing); kidney: 95.0495% (minimum 99%, Missing); liver: 89.1641% (minimum 99%, Missing); lung: 91.4286% (minimum 99%, Missing); lymph node: 62.4729% (minimum 97%, Missing); midbrain: 92.0128% (minimum 99%, Missing); pancreas: 95.0495% (minimum 99%, Missing); parathyroid gland: 93.8111% (minimum 97%, Missing); pituitary gland: 95.3642% (minimum 99%, Missing); rectum: 78.6885% (minimum 97%, Missing); retina: 92.3077% (minimum 99%, Missing); salivary gland: 91.1392% (minimum 97%, Missing); skeletal muscle: 88.0734% (minimum 99%, Missing); skin: 76.3926% (minimum 95%, Missing); small intestine: 83.4783% (minimum 99%, Missing); smooth muscle: 88.8889% (minimum 99%, Missing); spinal cord: 92.0128% (minimum 99%, Missing); spleen: 85.2071% (minimum 90%, Approved); stomach: 88.8889% (minimum 97%, Missing); thymus: 61.5385% (minimum 95%, Missing); tongue: 88.3436% (minimum 97%, Missing); urinary bladder: 88.6154% (minimum 97%, Missing)",0,6,partial,33.2,17.3,18,"bone marrow: 33.2 nTPM (vital, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 17.3 nTPM (protected, limit 2); skin: 8.9 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 2); esophagus: 7.3 nTPM (protected, limit 2); colon: 7.1 nTPM (protected, limit 2); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); heart muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000153044,CENPH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.334615,-0.345271,-0.515484
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.9,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; tonsil,ENSG00000153060,TEKT5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.7342% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.7342% (minimum 99%, Baseline (adaptation disabled)); liver: 97.5000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.9,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; tonsil,ENSG00000153060,TEKT5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0468051,0.00196262,-0.015
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.7342% (minimum 99%, Missing); hippocampal formation: 98.7342% (minimum 99%, Missing); liver: 97.5000% (minimum 99%, Missing)",0,80,unavailable,0.8,0.9,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; tonsil,ENSG00000153060,TEKT5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0468051,0.00196262,-0.015
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.9,4.5,0.6,"lung: 8.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); parathyroid gland: 2.7 nTPM (protected, limit 2); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153093,ACOXL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5915% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.3659% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.8904% (minimum 99%, Baseline (adaptation disabled)); colon: 94.5946% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.2222% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.5946% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.5946% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.8904% (minimum 99%, Baseline (adaptation disabled)); lung: 44.0252% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.9091% (minimum 97%, Baseline (adaptation disabled)); pancreas: 92.1053% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 72.1649% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.2222% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.8904% (minimum 97%, Baseline (adaptation disabled)); retina: 93.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.5946% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.2222% (minimum 99%, Baseline (adaptation disabled)); skin: 94.5946% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.2222% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.1053% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.8904% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.1053% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 60.8696% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.9,4.5,0.6,"lung: 8.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); parathyroid gland: 2.7 nTPM (protected, limit 2); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153093,ACOXL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0289474,-0.361304,-0.549748
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.2222% (minimum 99%, Missing); basal ganglia: 98.5915% (minimum 99%, Missing); bone marrow: 85.3659% (minimum 99%, Missing); cerebral cortex: 95.8904% (minimum 99%, Missing); colon: 94.5946% (minimum 97%, Missing); duodenum: 97.2222% (minimum 99%, Missing); esophagus: 94.5946% (minimum 97%, Missing); heart muscle: 94.5946% (minimum 99%, Missing); kidney: 95.8904% (minimum 99%, Missing); lung: 44.0252% (minimum 99%, Missing); lymph node: 90.9091% (minimum 97%, Missing); pancreas: 92.1053% (minimum 99%, Missing); parathyroid gland: 72.1649% (minimum 97%, Missing); pituitary gland: 97.2222% (minimum 99%, Missing); rectum: 95.8904% (minimum 97%, Missing); retina: 93.3333% (minimum 99%, Missing); salivary gland: 94.5946% (minimum 97%, Missing); skeletal muscle: 97.2222% (minimum 99%, Missing); skin: 94.5946% (minimum 95%, Missing); small intestine: 97.2222% (minimum 99%, Missing); spleen: 92.1053% (minimum 95%, Missing); stomach: 95.8904% (minimum 97%, Missing); thyroid gland: 92.1053% (minimum 95%, Missing); urinary bladder: 60.8696% (minimum 97%, Missing)",0,80,unavailable,8.9,4.5,0.6,"lung: 8.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); parathyroid gland: 2.7 nTPM (protected, limit 2); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153093,ACOXL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0289474,-0.361304,-0.549748
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,57.4,2.5,2.6,"heart muscle: 57.4 nTPM (vital, limit 6); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 6); choroid plexus: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153132,CLGN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.5159% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.9238% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.3943% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.8705% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.3164% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.2663% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.3164% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 65.7722% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9238% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.8297% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2663% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2191% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1317% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.0066% (minimum 99%, Baseline (adaptation disabled)); retina: 86.8504% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9238% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7466% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9238% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,57.4,2.5,2.6,"heart muscle: 57.4 nTPM (vital, limit 1); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); bone marrow: 2.4 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153132,CLGN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0269708,0.00783688,-0.332278
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.5159% (minimum 95%, Enhanced); amygdala: 98.9238% (minimum 99%, Missing); basal ganglia: 98.3943% (minimum 99%, Missing); cerebellum: 93.3164% (minimum 95%, Enhanced); choroid plexus: 93.3164% (minimum 99%, Missing); heart muscle: 65.7722% (minimum 95%, Enhanced); hippocampal formation: 98.9238% (minimum 99%, Missing); hypothalamus: 95.8297% (minimum 99%, Missing); midbrain: 98.2191% (minimum 99%, Missing); pituitary gland: 91.0066% (minimum 99%, Missing); retina: 86.8504% (minimum 99%, Missing); spinal cord: 98.9238% (minimum 99%, Missing)",0,1,partial,57.4,2.5,2.6,"heart muscle: 57.4 nTPM (vital, limit 6); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 6); choroid plexus: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153132,CLGN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0287045,0.0165832,-0.292278
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,66.4,1.1,"parathyroid gland: 66.4 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153157,SYCP2L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.7838% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.1765% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.1111% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.1111% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.5789% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.0930% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.5789% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.1765% (minimum 99%, Baseline (adaptation disabled)); colon: 91.1765% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.8750% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.9394% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.0930% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.1111% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.5714% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.8095% (minimum 99%, Baseline (adaptation disabled)); liver: 96.8750% (minimum 99%, Baseline (adaptation disabled)); lung: 64.5833% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.5714% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.1111% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.9574% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 4.4604% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.1765% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.9394% (minimum 97%, Baseline (adaptation disabled)); retina: 81.5789% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.1765% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.9394% (minimum 99%, Baseline (adaptation disabled)); skin: 88.5714% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.1765% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.9394% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.1111% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.1111% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.1765% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 73.8095% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.5000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 91.1765% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.7,66.4,1.1,"parathyroid gland: 66.4 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153157,SYCP2L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.211905,-0.925396,-0.344167
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.7838% (minimum 95%, Missing); adrenal gland: 91.1765% (minimum 99%, Missing); amygdala: 86.1111% (minimum 99%, Missing); basal ganglia: 86.1111% (minimum 99%, Missing); bone marrow: 81.5789% (minimum 99%, Missing); cerebellum: 72.0930% (minimum 99%, Missing); cerebral cortex: 81.5789% (minimum 99%, Missing); choroid plexus: 91.1765% (minimum 99%, Missing); colon: 91.1765% (minimum 97%, Missing); duodenum: 96.8750% (minimum 99%, Missing); esophagus: 93.9394% (minimum 97%, Missing); heart muscle: 72.0930% (minimum 99%, Missing); hippocampal formation: 86.1111% (minimum 99%, Missing); hypothalamus: 88.5714% (minimum 99%, Missing); kidney: 73.8095% (minimum 99%, Missing); liver: 96.8750% (minimum 99%, Missing); lung: 64.5833% (minimum 99%, Missing); lymph node: 88.5714% (minimum 97%, Missing); midbrain: 86.1111% (minimum 99%, Missing); pancreas: 65.9574% (minimum 99%, Missing); parathyroid gland: 4.4604% (minimum 97%, Missing); pituitary gland: 91.1765% (minimum 99%, Missing); rectum: 93.9394% (minimum 97%, Missing); retina: 81.5789% (minimum 99%, Missing); salivary gland: 91.1765% (minimum 97%, Missing); skeletal muscle: 93.9394% (minimum 99%, Missing); skin: 88.5714% (minimum 95%, Missing); small intestine: 91.1765% (minimum 99%, Missing); smooth muscle: 93.9394% (minimum 99%, Missing); spinal cord: 86.1111% (minimum 99%, Missing); spleen: 86.1111% (minimum 95%, Missing); stomach: 91.1765% (minimum 97%, Missing); thyroid gland: 73.8095% (minimum 95%, Missing); tongue: 77.5000% (minimum 97%, Missing); urinary bladder: 91.1765% (minimum 97%, Missing)",0,80,unavailable,1.7,66.4,1.1,"parathyroid gland: 66.4 nTPM (protected, limit 2); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153157,SYCP2L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.211905,-0.925396,-0.344167
True,compatible,,True,True,False,,0,80,unavailable,0.9,0.3,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153165,RGPD3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.5294% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.7143% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.1014% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.3662% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.1014% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.5294% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5294% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.7143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.5405% (minimum 99%, Baseline (adaptation disabled)); liver: 90.5405% (minimum 99%, Baseline (adaptation disabled)); lung: 97.1014% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.0556% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.1014% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.0556% (minimum 99%, Baseline (adaptation disabled)); retina: 88.1579% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.5294% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5294% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5294% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.7143% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.0556% (minimum 95%, Baseline (adaptation disabled)); thymus: 77.9070% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.7143% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.9,0.3,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153165,RGPD3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.17093,-0.0128571,-0.108421
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.5294% (minimum 99%, Missing); amygdala: 95.7143% (minimum 99%, Missing); basal ganglia: 95.7143% (minimum 99%, Missing); bone marrow: 95.7143% (minimum 99%, Missing); cerebellum: 97.1014% (minimum 99%, Missing); cerebral cortex: 94.3662% (minimum 99%, Missing); choroid plexus: 97.1014% (minimum 99%, Missing); duodenum: 98.5294% (minimum 99%, Missing); heart muscle: 98.5294% (minimum 99%, Missing); hippocampal formation: 95.7143% (minimum 99%, Missing); hypothalamus: 95.7143% (minimum 99%, Missing); kidney: 90.5405% (minimum 99%, Missing); liver: 90.5405% (minimum 99%, Missing); lung: 97.1014% (minimum 99%, Missing); midbrain: 93.0556% (minimum 99%, Missing); pancreas: 97.1014% (minimum 99%, Missing); pituitary gland: 93.0556% (minimum 99%, Missing); retina: 88.1579% (minimum 99%, Missing); skeletal muscle: 98.5294% (minimum 99%, Missing); small intestine: 98.5294% (minimum 99%, Missing); smooth muscle: 98.5294% (minimum 99%, Missing); spinal cord: 95.7143% (minimum 99%, Missing); spleen: 93.0556% (minimum 95%, Missing); thymus: 77.9070% (minimum 95%, Missing); urinary bladder: 95.7143% (minimum 97%, Missing)",0,80,unavailable,0.9,0.3,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153165,RGPD3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.17093,-0.0128571,-0.108421
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,16.7,15.1,13.3,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 2); thyroid gland: 13.3 nTPM (manageable, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 2); adipose tissue: 12.2 nTPM (manageable, limit 5); thymus: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); skeletal muscle: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 2); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); lymph node: 8.9 nTPM (protected, limit 2); esophagus: 8.9 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); stomach: 8.3 nTPM (protected, limit 2); cerebellum: 8.2 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000153207,AHCTF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.0824% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.3953% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.7781% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.2351% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.3527% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.3451% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.6772% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.5385% (minimum 99%, Baseline (adaptation disabled)); colon: 78.1638% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.1135% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.9703% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.1135% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.7781% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.5172% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.0171% (minimum 99%, Baseline (adaptation disabled)); liver: 74.8219% (minimum 99%, Baseline (adaptation disabled)); lung: 82.0312% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.9703% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.0405% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.6423% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.2670% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.5544% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.4607% (minimum 97%, Baseline (adaptation disabled)); retina: 80.1527% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.6772% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 74.8219% (minimum 99%, Baseline (adaptation disabled)); skin: 80.1527% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.1135% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.5627% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.7781% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.7778% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.1457% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.5806% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.3125% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.5966% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.0870% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,16.7,15.1,13.3,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 2); thyroid gland: 13.3 nTPM (manageable, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 2); adipose tissue: 12.2 nTPM (manageable, limit 5); thymus: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); skeletal muscle: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 2); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); lymph node: 8.9 nTPM (protected, limit 2); esophagus: 8.9 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); stomach: 8.3 nTPM (protected, limit 2); cerebellum: 8.2 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000153207,AHCTF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.246875,-0.294034,-0.336473
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.0824% (minimum 95%, Missing); adrenal gland: 81.3953% (minimum 99%, Missing); amygdala: 90.7781% (minimum 99%, Missing); basal ganglia: 89.2351% (minimum 99%, Missing); bone marrow: 65.3527% (minimum 99%, Missing); cerebellum: 79.3451% (minimum 99%, Missing); cerebral cortex: 82.6772% (minimum 99%, Missing); choroid plexus: 86.5385% (minimum 99%, Missing); colon: 78.1638% (minimum 97%, Missing); duodenum: 83.1135% (minimum 99%, Missing); esophagus: 77.9703% (minimum 97%, Missing); heart muscle: 83.1135% (minimum 99%, Missing); hippocampal formation: 90.7781% (minimum 99%, Missing); hypothalamus: 90.5172% (minimum 99%, Missing); kidney: 77.0171% (minimum 99%, Missing); liver: 74.8219% (minimum 99%, Missing); lung: 82.0312% (minimum 99%, Missing); lymph node: 77.9703% (minimum 97%, Missing); midbrain: 91.0405% (minimum 99%, Missing); pancreas: 76.6423% (minimum 99%, Missing); parathyroid gland: 71.2670% (minimum 97%, Missing); pituitary gland: 83.5544% (minimum 99%, Missing); rectum: 82.4607% (minimum 97%, Missing); retina: 80.1527% (minimum 99%, Missing); salivary gland: 82.6772% (minimum 97%, Missing); skeletal muscle: 74.8219% (minimum 99%, Missing); skin: 80.1527% (minimum 95%, Missing); small intestine: 83.1135% (minimum 99%, Missing); smooth muscle: 80.5627% (minimum 99%, Missing); spinal cord: 90.7781% (minimum 99%, Missing); spleen: 77.7778% (minimum 95%, Missing); stomach: 79.1457% (minimum 97%, Missing); thymus: 72.5806% (minimum 95%, Missing); thyroid gland: 70.3125% (minimum 95%, Missing); tongue: 67.5966% (minimum 97%, Missing); urinary bladder: 76.0870% (minimum 97%, Missing)",0,2,partial,16.7,15.1,13.3,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 2); thyroid gland: 13.3 nTPM (manageable, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 2); adipose tissue: 12.2 nTPM (manageable, limit 5); thymus: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); skeletal muscle: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 2); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); lymph node: 8.9 nTPM (protected, limit 2); esophagus: 8.9 nTPM (protected, limit 2); colon: 8.8 nTPM (protected, limit 2); stomach: 8.3 nTPM (protected, limit 2); cerebellum: 8.2 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000153207,AHCTF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.246875,-0.294034,-0.336473
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3,3.1,1.2,"parathyroid gland: 3.1 nTPM (protected, limit 2); kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000153237,CCDC148,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.1176% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.1176% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.2105% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.1176% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.3377% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.9592% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.3077% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.3077% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.5385% (minimum 99%, Baseline (adaptation disabled)); liver: 96.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 92.3077% (minimum 99%, Baseline (adaptation disabled)); midbrain: 92.3077% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.7595% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.7586% (minimum 99%, Baseline (adaptation disabled)); retina: 65.7534% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.8889% (minimum 97%, Baseline (adaptation disabled)); smooth muscle: 97.9592% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.5660% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 80.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3,3.1,1.2,"parathyroid gland: 3.1 nTPM (protected, limit 2); kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000153237,CCDC148,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.15,-0.362405,-0.374615
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.1176% (minimum 99%, Missing); amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 92.3077% (minimum 99%, Missing); cerebellum: 84.2105% (minimum 99%, Missing); cerebral cortex: 94.1176% (minimum 99%, Missing); choroid plexus: 62.3377% (minimum 99%, Missing); heart muscle: 97.9592% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); kidney: 61.5385% (minimum 99%, Missing); liver: 96.0000% (minimum 99%, Missing); lung: 92.3077% (minimum 99%, Missing); midbrain: 92.3077% (minimum 99%, Missing); pancreas: 96.0000% (minimum 99%, Missing); parathyroid gland: 60.7595% (minimum 97%, Missing); pituitary gland: 82.7586% (minimum 99%, Missing); retina: 65.7534% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); smooth muscle: 97.9592% (minimum 99%, Missing); spinal cord: 90.5660% (minimum 99%, Missing); thyroid gland: 80.0000% (minimum 95%, Missing)",0,80,unavailable,3,3.1,1.2,"parathyroid gland: 3.1 nTPM (protected, limit 2); kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; tonsil,ENSG00000153237,CCDC148,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.15,-0.362405,-0.374615
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,60.6,2.4,1.6,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000153347,FAM81B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.2040% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.0762% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 57.2336% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 91.7421% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.0835% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.3690% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.0653% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0762% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.8287% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.7497% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.8287% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,60.6,2.4,1.6,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000153347,FAM81B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.030653,0.00125749,-0.417664
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.2040% (minimum 99%, Missing); basal ganglia: 95.0762% (minimum 99%, Missing); choroid plexus: 57.2336% (minimum 99%, Missing); heart muscle: 91.7421% (minimum 98%, Approved); hippocampal formation: 94.0835% (minimum 99%, Missing); hypothalamus: 92.3690% (minimum 99%, Missing); lung: 95.0762% (minimum 98%, Approved); midbrain: 97.8287% (minimum 99%, Missing); pituitary gland: 95.7497% (minimum 99%, Missing); spinal cord: 97.8287% (minimum 99%, Missing)",0,2,partial,60.6,2.4,1.6,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000153347,FAM81B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.05,0.0212575,-0.417664
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12,0.5,0.7,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000153495,TEX29,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 89.5204% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.9889% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.8641% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.7692% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.0545% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.1832% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.8641% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6301% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2456% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.0545% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.8235% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1098% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.6301% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,12,0.5,0.7,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000153495,TEX29,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0363014,0.0201768,-0.182308
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 89.5204% (minimum 99%, Missing); basal ganglia: 92.9889% (minimum 99%, Missing); cerebellum: 97.8641% (minimum 99%, Missing); cerebral cortex: 80.7692% (minimum 99%, Missing); choroid plexus: 98.0545% (minimum 99%, Missing); hippocampal formation: 96.1832% (minimum 99%, Missing); hypothalamus: 97.8641% (minimum 99%, Missing); kidney: 98.6301% (minimum 99%, Missing); liver: 98.2456% (minimum 99%, Missing); midbrain: 98.0545% (minimum 99%, Missing); pancreas: 98.8235% (minimum 99%, Missing); pituitary gland: 97.1098% (minimum 99%, Missing); spinal cord: 98.6301% (minimum 99%, Missing)",0,80,unavailable,12,0.5,0.7,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000153495,TEX29,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0363014,0.0201768,-0.182308
True,compatible,,True,True,False,,0,3,partial,0.5,0.3,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000153498,SPACA7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0.5,0.3,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000153498,SPACA7,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.047558,0.0263415,0.00391727
True,compatible,,True,True,True,,0,3,partial,0.5,0.3,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000153498,SPACA7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00634146
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000153684,GOLGA8F,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000153684,GOLGA8F,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.00186992
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000153684,GOLGA8F,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.00186992
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,18.3,12.8,4.4,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 2); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); smooth muscle: 6.3 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 4); urinary bladder: 4.2 nTPM (protected, limit 2); stomach: 3.9 nTPM (protected, limit 2); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000153721,CNKSR3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.2727% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.0588% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.7234% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.5699% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.2439% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.5000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.0465% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 52.4823% (minimum 99%, Baseline (adaptation disabled)); colon: 54.0146% (minimum 97%, Baseline (adaptation disabled)); duodenum: 56.9231% (minimum 99%, Baseline (adaptation disabled)); esophagus: 36.6337% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.8148% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.5102% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.1461% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.3401% (minimum 99%, Baseline (adaptation disabled)); liver: 44.3114% (minimum 99%, Baseline (adaptation disabled)); lung: 67.2727% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.0909% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.2887% (minimum 99%, Baseline (adaptation disabled)); pancreas: 28.7938% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.3580% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.0833% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.1589% (minimum 97%, Baseline (adaptation disabled)); retina: 74.7475% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.3643% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.0588% (minimum 99%, Baseline (adaptation disabled)); skin: 66.0714% (minimum 95%, Baseline (adaptation disabled)); small intestine: 54.4118% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 54.0146% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.4867% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.7119% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.4867% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.8947% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.7234% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.0909% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.7931% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,18.3,12.8,4.4,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 2); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); smooth muscle: 6.3 nTPM (vital, limit 1); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); urinary bladder: 4.2 nTPM (protected, limit 2); stomach: 3.9 nTPM (protected, limit 2); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000153721,CNKSR3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.322881,-0.603663,-0.702062
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.2727% (minimum 90%, Approved); adrenal gland: 87.0588% (minimum 99%, Missing); amygdala: 78.7234% (minimum 99%, Missing); basal ganglia: 79.5699% (minimum 99%, Missing); bone marrow: 90.2439% (minimum 99%, Missing); cerebellum: 92.5000% (minimum 99%, Missing); cerebral cortex: 86.0465% (minimum 99%, Missing); choroid plexus: 52.4823% (minimum 99%, Missing); colon: 54.0146% (minimum 97%, Missing); duodenum: 56.9231% (minimum 99%, Missing); esophagus: 36.6337% (minimum 97%, Missing); heart muscle: 54.8148% (minimum 99%, Missing); hippocampal formation: 75.5102% (minimum 99%, Missing); hypothalamus: 83.1461% (minimum 99%, Missing); kidney: 50.3401% (minimum 99%, Missing); liver: 44.3114% (minimum 99%, Missing); lung: 67.2727% (minimum 99%, Missing); lymph node: 84.0909% (minimum 97%, Missing); midbrain: 76.2887% (minimum 99%, Missing); pancreas: 28.7938% (minimum 99%, Missing); parathyroid gland: 91.3580% (minimum 97%, Missing); pituitary gland: 77.0833% (minimum 99%, Missing); rectum: 69.1589% (minimum 97%, Missing); retina: 74.7475% (minimum 99%, Missing); salivary gland: 57.3643% (minimum 95%, Approved); skeletal muscle: 87.0588% (minimum 99%, Missing); skin: 66.0714% (minimum 95%, Missing); small intestine: 54.4118% (minimum 99%, Missing); smooth muscle: 54.0146% (minimum 98%, Approved); spinal cord: 65.4867% (minimum 99%, Missing); spleen: 62.7119% (minimum 95%, Missing); stomach: 65.4867% (minimum 97%, Missing); thymus: 77.8947% (minimum 95%, Missing); thyroid gland: 78.7234% (minimum 95%, Missing); tongue: 84.0909% (minimum 97%, Missing); urinary bladder: 63.7931% (minimum 97%, Missing)",0,1,partial,18.3,12.8,4.4,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 2); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); smooth muscle: 6.3 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 4); urinary bladder: 4.2 nTPM (protected, limit 2); stomach: 3.9 nTPM (protected, limit 2); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000153721,CNKSR3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.322881,-0.603663,-0.702062
True,compatible,,True,True,False,,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000153779,TGIF2LX,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000153779,TGIF2LX,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000153779,TGIF2LX,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.6,6.6,4.2,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); spinal cord: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153790,SPMIP4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 89.3258% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.5460% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.2179% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.0992% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.3620% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2998% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.5460% (minimum 99%, Baseline (adaptation disabled)); colon: 90.5983% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.6672% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.3636% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.8037% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.3966% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.5460% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.9276% (minimum 99%, Baseline (adaptation disabled)); liver: 97.9969% (minimum 99%, Baseline (adaptation disabled)); lung: 96.2179% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.2096% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.3966% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.9512% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.3620% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.8037% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.5294% (minimum 97%, Baseline (adaptation disabled)); retina: 96.0725% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.9254% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.6047% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.5022% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.6391% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.6391% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.2222% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.5294% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.8053% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.0828% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.5022% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7.6,6.6,4.2,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); spinal cord: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153790,SPMIP4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0119469,-0.0640171,-0.0967416
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 89.3258% (minimum 99%, Missing); amygdala: 97.5460% (minimum 99%, Missing); basal ganglia: 96.2179% (minimum 99%, Missing); bone marrow: 97.0992% (minimum 99%, Missing); cerebellum: 94.3620% (minimum 99%, Missing); cerebral cortex: 98.2998% (minimum 99%, Missing); choroid plexus: 97.5460% (minimum 99%, Missing); colon: 90.5983% (minimum 97%, Missing); duodenum: 93.6672% (minimum 99%, Missing); esophagus: 96.3636% (minimum 97%, Missing); heart muscle: 96.8037% (minimum 99%, Missing); hippocampal formation: 97.3966% (minimum 99%, Missing); hypothalamus: 97.5460% (minimum 99%, Missing); kidney: 95.9276% (minimum 99%, Missing); liver: 97.9969% (minimum 99%, Missing); lung: 96.2179% (minimum 99%, Missing); lymph node: 95.2096% (minimum 97%, Missing); midbrain: 97.3966% (minimum 99%, Missing); pancreas: 96.9512% (minimum 99%, Missing); parathyroid gland: 94.3620% (minimum 97%, Missing); pituitary gland: 96.8037% (minimum 99%, Missing); rectum: 93.5294% (minimum 97%, Missing); retina: 96.0725% (minimum 99%, Missing); salivary gland: 94.9254% (minimum 97%, Missing); skeletal muscle: 98.6047% (minimum 99%, Missing); small intestine: 94.5022% (minimum 99%, Missing); smooth muscle: 95.6391% (minimum 99%, Missing); spinal cord: 95.6391% (minimum 99%, Missing); spleen: 94.2222% (minimum 95%, Missing); stomach: 93.5294% (minimum 97%, Missing); thymus: 93.8053% (minimum 95%, Missing); thyroid gland: 94.0828% (minimum 95%, Missing); urinary bladder: 94.5022% (minimum 97%, Missing)",0,80,unavailable,7.6,6.6,4.2,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); spinal cord: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153790,SPMIP4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0119469,-0.0640171,-0.0967416
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.5,14.6,6.6,"rectum: 14.6 nTPM (protected, limit 2); lymph node: 12.5 nTPM (protected, limit 2); colon: 9.8 nTPM (protected, limit 2); adrenal gland: 8.5 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153898,MCOLN2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 84.7826% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 31.4516% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.0909% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.5000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.8571% (minimum 99%, Baseline (adaptation disabled)); colon: 28.4672% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.9091% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.7826% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.6977% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.1220% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.5918% (minimum 99%, Baseline (adaptation disabled)); liver: 86.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 42.3913% (minimum 99%, Baseline (adaptation disabled)); lymph node: 23.7805% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.9787% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.6364% (minimum 99%, Baseline (adaptation disabled)); rectum: 21.0811% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 84.7826% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.1220% (minimum 99%, Baseline (adaptation disabled)); skin: 66.1017% (minimum 95%, Baseline (adaptation disabled)); small intestine: 42.3913% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.8571% (minimum 99%, Baseline (adaptation disabled)); spleen: 37.1429% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 63.9344% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.6364% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 72.2222% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.5,14.6,6.6,"rectum: 14.6 nTPM (protected, limit 2); lymph node: 12.5 nTPM (protected, limit 2); colon: 9.8 nTPM (protected, limit 2); adrenal gland: 8.5 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153898,MCOLN2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.578571,-0.759189,-0.675484
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 84.7826% (minimum 95%, Missing); adrenal gland: 31.4516% (minimum 99%, Missing); amygdala: 97.5000% (minimum 99%, Missing); basal ganglia: 97.5000% (minimum 99%, Missing); bone marrow: 59.0909% (minimum 99%, Missing); cerebral cortex: 97.5000% (minimum 99%, Missing); choroid plexus: 92.8571% (minimum 99%, Missing); colon: 28.4672% (minimum 97%, Missing); duodenum: 70.9091% (minimum 99%, Missing); esophagus: 84.7826% (minimum 97%, Missing); heart muscle: 90.6977% (minimum 99%, Missing); hippocampal formation: 95.1220% (minimum 99%, Missing); hypothalamus: 97.5000% (minimum 99%, Missing); kidney: 79.5918% (minimum 99%, Missing); liver: 86.6667% (minimum 99%, Missing); lung: 42.3913% (minimum 99%, Missing); lymph node: 23.7805% (minimum 97%, Missing); midbrain: 97.5000% (minimum 99%, Missing); pancreas: 82.9787% (minimum 99%, Missing); parathyroid gland: 78.0000% (minimum 97%, Missing); pituitary gland: 88.6364% (minimum 99%, Missing); rectum: 21.0811% (minimum 97%, Missing); salivary gland: 84.7826% (minimum 97%, Missing); skeletal muscle: 95.1220% (minimum 99%, Missing); skin: 66.1017% (minimum 95%, Missing); small intestine: 42.3913% (minimum 99%, Missing); smooth muscle: 86.6667% (minimum 99%, Missing); spinal cord: 92.8571% (minimum 99%, Missing); spleen: 37.1429% (minimum 95%, Missing); stomach: 65.0000% (minimum 97%, Missing); thymus: 63.9344% (minimum 95%, Missing); thyroid gland: 88.6364% (minimum 95%, Missing); urinary bladder: 72.2222% (minimum 97%, Missing)",0,80,unavailable,8.5,14.6,6.6,"rectum: 14.6 nTPM (protected, limit 2); lymph node: 12.5 nTPM (protected, limit 2); colon: 9.8 nTPM (protected, limit 2); adrenal gland: 8.5 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153898,MCOLN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.578571,-0.759189,-0.675484
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.6,5.7,2.5,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 2); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 2); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153982,GDPD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.2222% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 61.4815% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.8652% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.6939% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 45.3552% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 41.7085% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.1071% (minimum 99%, Baseline (adaptation disabled)); colon: 82.1782% (minimum 97%, Baseline (adaptation disabled)); duodenum: 59.7122% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.2088% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.2979% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.0420% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 52.2013% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.5825% (minimum 99%, Baseline (adaptation disabled)); liver: 89.2473% (minimum 99%, Baseline (adaptation disabled)); lung: 79.0476% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.2088% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.8788% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.2473% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.2857% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.6939% (minimum 97%, Baseline (adaptation disabled)); retina: 59.7122% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.0476% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.8384% (minimum 99%, Baseline (adaptation disabled)); skin: 86.4583% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.9355% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.3684% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.8730% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.5670% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.4060% (minimum 97%, Baseline (adaptation disabled)); thymus: 83.8384% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 76.8519% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.2222% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.3684% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.6,5.7,2.5,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 2); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 2); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153982,GDPD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.181481,-0.377143,-0.572915
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.2222% (minimum 95%, Missing); adrenal gland: 83.0000% (minimum 99%, Missing); amygdala: 61.4815% (minimum 99%, Missing); basal ganglia: 58.8652% (minimum 99%, Missing); bone marrow: 84.6939% (minimum 99%, Missing); cerebellum: 45.3552% (minimum 99%, Missing); cerebral cortex: 41.7085% (minimum 99%, Missing); choroid plexus: 74.1071% (minimum 99%, Missing); colon: 82.1782% (minimum 97%, Missing); duodenum: 59.7122% (minimum 99%, Missing); esophagus: 91.2088% (minimum 97%, Missing); heart muscle: 88.2979% (minimum 99%, Missing); hippocampal formation: 58.0420% (minimum 99%, Missing); hypothalamus: 52.2013% (minimum 99%, Missing); kidney: 80.5825% (minimum 99%, Missing); liver: 89.2473% (minimum 99%, Missing); lung: 79.0476% (minimum 99%, Missing); lymph node: 91.2088% (minimum 97%, Missing); midbrain: 62.8788% (minimum 99%, Missing); pancreas: 89.2473% (minimum 99%, Missing); parathyroid gland: 59.2857% (minimum 97%, Missing); pituitary gland: 83.0000% (minimum 99%, Missing); rectum: 84.6939% (minimum 97%, Missing); retina: 59.7122% (minimum 99%, Missing); salivary gland: 79.0476% (minimum 97%, Missing); skeletal muscle: 83.8384% (minimum 99%, Missing); skin: 86.4583% (minimum 95%, Missing); small intestine: 66.9355% (minimum 99%, Missing); smooth muscle: 87.3684% (minimum 99%, Missing); spinal cord: 65.8730% (minimum 99%, Missing); spleen: 85.5670% (minimum 95%, Missing); stomach: 62.4060% (minimum 97%, Missing); thymus: 83.8384% (minimum 95%, Missing); thyroid gland: 76.8519% (minimum 95%, Missing); tongue: 92.2222% (minimum 97%, Missing); urinary bladder: 87.3684% (minimum 97%, Missing)",0,80,unavailable,11.6,5.7,2.5,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 2); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 2); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000153982,GDPD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.181481,-0.377143,-0.572915
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000154007,ASB17,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000154007,ASB17,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00589322
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000154007,ASB17,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00589322
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,12.7,2.3,2,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 6); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154040,CABYR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9273% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.3011% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.9936% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.4893% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.8739% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6829% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.2357% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2684% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.3606% (minimum 99%, Baseline (adaptation disabled)); retina: 98.2030% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.8279% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.7800% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,12.7,2.3,2,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154040,CABYR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0432683,0.0222663,-0.0312606
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.3011% (minimum 99%, Missing); basal ganglia: 98.9936% (minimum 99%, Missing); choroid plexus: 95.8739% (minimum 99%, Missing); hippocampal formation: 97.6829% (minimum 99%, Missing); hypothalamus: 98.2357% (minimum 99%, Missing); midbrain: 98.2684% (minimum 99%, Missing); pituitary gland: 97.3606% (minimum 99%, Missing); retina: 98.2030% (minimum 99%, Missing); spinal cord: 97.7800% (minimum 99%, Missing)",0,1,partial,12.7,2.3,2,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 6); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154040,CABYR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0452782,0.0296612,-0.0312606
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,23.5,26.9,31.5,"thyroid gland: 31.5 nTPM (manageable, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 4); salivary gland: 24.2 nTPM (protected, limit 2); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 2); esophagus: 21 nTPM (protected, limit 2); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (manageable, limit 10); heart muscle: 18.6 nTPM (vital, limit 1); hypothalamus: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 2); spinal cord: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 2); spleen: 14.8 nTPM (manageable, limit 10); rectum: 14.4 nTPM (protected, limit 2); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 2); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); amygdala: 11.8 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 2); skin: 11.1 nTPM (manageable, limit 5); thymus: 10.9 nTPM (manageable, limit 5); retina: 9.8 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000154059,IMPACT,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1075% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.1974% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.8938% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.5203% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.1633% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.0082% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.0210% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.9598% (minimum 99%, Baseline (adaptation disabled)); colon: 65.7480% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.1633% (minimum 99%, Baseline (adaptation disabled)); esophagus: 61.3971% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.2308% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.4942% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.7480% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.6995% (minimum 99%, Baseline (adaptation disabled)); liver: 60.7273% (minimum 99%, Baseline (adaptation disabled)); lung: 68.7243% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.8879% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.5203% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.6642% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.3897% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.4942% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.8745% (minimum 97%, Baseline (adaptation disabled)); retina: 77.3148% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.9861% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.0189% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0562% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.6113% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.7669% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.7243% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.2946% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.4426% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.3950% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 51.4638% (minimum 95%, Baseline (adaptation disabled)); tongue: 72.6087% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.2456% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,23.5,26.9,31.5,"thyroid gland: 31.5 nTPM (manageable, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 2); salivary gland: 24.2 nTPM (protected, limit 2); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 2); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (manageable, limit 5); heart muscle: 18.6 nTPM (vital, limit 1); hypothalamus: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 2); spinal cord: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); spleen: 14.8 nTPM (manageable, limit 5); rectum: 14.4 nTPM (protected, limit 2); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 2); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); amygdala: 11.8 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 2); skin: 11.1 nTPM (manageable, limit 5); thymus: 10.9 nTPM (manageable, limit 5); retina: 9.8 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000154059,IMPACT,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.435362,-0.416103,-0.403005
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1075% (minimum 90%, Approved); adrenal gland: 62.1974% (minimum 99%, Missing); amygdala: 73.8938% (minimum 99%, Missing); basal ganglia: 71.5203% (minimum 99%, Missing); bone marrow: 68.1633% (minimum 99%, Missing); cerebellum: 91.0082% (minimum 99%, Missing); cerebral cortex: 70.0210% (minimum 99%, Missing); choroid plexus: 78.9598% (minimum 99%, Missing); colon: 65.7480% (minimum 97%, Missing); duodenum: 68.1633% (minimum 99%, Missing); esophagus: 61.3971% (minimum 97%, Missing); heart muscle: 64.2308% (minimum 99%, Missing); hippocampal formation: 77.4942% (minimum 99%, Missing); hypothalamus: 65.7480% (minimum 99%, Missing); kidney: 58.6995% (minimum 99%, Missing); liver: 60.7273% (minimum 98%, Approved); lung: 68.7243% (minimum 98%, Approved); lymph node: 74.8879% (minimum 97%, Missing); midbrain: 71.5203% (minimum 99%, Missing); pancreas: 62.6642% (minimum 99%, Missing); parathyroid gland: 55.3897% (minimum 95%, Approved); pituitary gland: 77.4942% (minimum 99%, Missing); rectum: 69.8745% (minimum 97%, Missing); retina: 77.3148% (minimum 99%, Missing); salivary gland: 57.9861% (minimum 97%, Missing); skeletal muscle: 63.0189% (minimum 99%, Missing); skin: 75.0562% (minimum 95%, Missing); small intestine: 67.6113% (minimum 99%, Missing); smooth muscle: 72.7669% (minimum 99%, Missing); spinal cord: 68.7243% (minimum 99%, Missing); spleen: 69.2946% (minimum 90%, Approved); stomach: 68.4426% (minimum 97%, Missing); thymus: 75.3950% (minimum 95%, Missing); thyroid gland: 51.4638% (minimum 95%, Missing); tongue: 72.6087% (minimum 97%, Missing); urinary bladder: 73.2456% (minimum 97%, Missing)",0,3,partial,23.5,26.9,31.5,"thyroid gland: 31.5 nTPM (manageable, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 4); salivary gland: 24.2 nTPM (protected, limit 2); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 2); esophagus: 21 nTPM (protected, limit 2); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (manageable, limit 10); heart muscle: 18.6 nTPM (vital, limit 1); hypothalamus: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 2); spinal cord: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 2); spleen: 14.8 nTPM (manageable, limit 10); rectum: 14.4 nTPM (protected, limit 2); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 2); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); amygdala: 11.8 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 2); skin: 11.1 nTPM (manageable, limit 5); thymus: 10.9 nTPM (manageable, limit 5); retina: 9.8 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000154059,IMPACT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.435362,-0.396103,-0.403005
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,23.7,0.4,1.5,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000154099,DNAAF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.4305% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.6160% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.0467% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.3392% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.5556% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.9408% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.4094% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.4231% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.7728% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2103% (minimum 99%, Baseline (adaptation disabled)); lung: 92.8118% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.5556% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.0216% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1239% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,23.7,0.4,1.5,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000154099,DNAAF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0169604,0.0209707,-0.340592
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 92.6160% (minimum 99%, Missing); basal ganglia: 89.0467% (minimum 99%, Missing); choroid plexus: 64.9408% (minimum 99%, Missing); hippocampal formation: 89.4094% (minimum 99%, Missing); hypothalamus: 84.4231% (minimum 99%, Missing); lung: 92.8118% (minimum 95%, Enhanced); midbrain: 97.5556% (minimum 99%, Missing); pituitary gland: 95.0216% (minimum 99%, Missing); spinal cord: 97.1239% (minimum 99%, Missing)",0,5,partial,23.7,0.4,1.5,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000154099,DNAAF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.340592
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,14.4,14.9,9.7,"parathyroid gland: 14.9 nTPM (protected, limit 2); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); adrenal gland: 7.3 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 2); lymph node: 7 nTPM (protected, limit 2); thymus: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 2); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 2); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); small intestine: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); bone marrow: 5.5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154114,TBCEL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7959% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 74.2690% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.1591% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.7802% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.9885% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.1458% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 46.8635% (minimum 99%, Baseline (adaptation disabled)); colon: 64.4670% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.5714% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.7802% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.9909% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.7514% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.9885% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.5616% (minimum 99%, Baseline (adaptation disabled)); liver: 47.3881% (minimum 99%, Baseline (adaptation disabled)); lung: 58.2569% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.4670% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.7514% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.2796% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 46.0145% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.8713% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.7802% (minimum 97%, Baseline (adaptation disabled)); retina: 61.3527% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.4639% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.0217% (minimum 99%, Baseline (adaptation disabled)); skin: 72.9885% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.7802% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.7963% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.5532% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.2549% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.0217% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.7959% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.6964% (minimum 95%, Baseline (adaptation disabled)); tongue: 63.1841% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.2796% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,14.4,14.9,9.7,"parathyroid gland: 14.9 nTPM (protected, limit 2); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); adrenal gland: 7.3 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 2); colon: 7 nTPM (protected, limit 2); thymus: 6.9 nTPM (manageable, limit 5); adipose tissue: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 2); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 2); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 2); bone marrow: 5.5 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); esophagus: 5.5 nTPM (protected, limit 2); midbrain: 5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154114,TBCEL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.383036,-0.509855,-0.521365
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7959% (minimum 90%, Approved); adrenal gland: 63.5000% (minimum 99%, Missing); amygdala: 74.2690% (minimum 99%, Missing); basal ganglia: 72.1591% (minimum 99%, Missing); bone marrow: 69.7802% (minimum 99%, Missing); cerebellum: 72.9885% (minimum 99%, Missing); cerebral cortex: 66.1458% (minimum 99%, Missing); choroid plexus: 46.8635% (minimum 99%, Missing); colon: 64.4670% (minimum 97%, Missing); duodenum: 72.5714% (minimum 99%, Missing); esophagus: 69.7802% (minimum 97%, Missing); heart muscle: 57.9909% (minimum 99%, Missing); hippocampal formation: 71.7514% (minimum 99%, Missing); hypothalamus: 72.9885% (minimum 99%, Missing); kidney: 62.5616% (minimum 99%, Missing); liver: 47.3881% (minimum 98%, Approved); lung: 58.2569% (minimum 99%, Missing); lymph node: 64.4670% (minimum 97%, Missing); midbrain: 71.7514% (minimum 99%, Missing); pancreas: 68.2796% (minimum 99%, Missing); parathyroid gland: 46.0145% (minimum 97%, Missing); pituitary gland: 62.8713% (minimum 99%, Missing); rectum: 69.7802% (minimum 97%, Missing); retina: 61.3527% (minimum 99%, Missing); salivary gland: 65.4639% (minimum 97%, Missing); skeletal muscle: 69.0217% (minimum 99%, Missing); skin: 72.9885% (minimum 95%, Missing); small intestine: 69.7802% (minimum 99%, Missing); smooth muscle: 58.7963% (minimum 99%, Missing); spinal cord: 67.5532% (minimum 99%, Missing); spleen: 62.2549% (minimum 95%, Missing); stomach: 69.0217% (minimum 97%, Missing); thymus: 64.7959% (minimum 95%, Missing); thyroid gland: 56.6964% (minimum 95%, Missing); tongue: 63.1841% (minimum 97%, Missing); urinary bladder: 68.2796% (minimum 97%, Missing)",0,4,partial,14.4,14.9,9.7,"parathyroid gland: 14.9 nTPM (protected, limit 2); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 2); adrenal gland: 7.3 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 2); lymph node: 7 nTPM (protected, limit 2); thymus: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 2); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 2); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); small intestine: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); bone marrow: 5.5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154114,TBCEL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.383036,-0.509855,-0.521365
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.2,0.2,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000154143,PANX3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"basal ganglia: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.2,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000154143,PANX3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.47,-0.49
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"basal ganglia: 50.0000% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing)",0,80,unavailable,0.2,0.2,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000154143,PANX3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.47,-0.49
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,0.6,53.6,62,"skin: 62 nTPM (manageable, limit 5); esophagus: 53.6 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 4)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000154227,CERS3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 35.4217% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.9899% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.1915% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 32.1663% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,0.6,53.6,62,"skin: 62 nTPM (manageable, limit 5); esophagus: 53.6 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000154227,CERS3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.628337,-0.615783,-0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 35.4217% (minimum 97%, Missing); pituitary gland: 98.9899% (minimum 99%, Missing); salivary gland: 78.1915% (minimum 95%, Approved); skeletal muscle: 98.0000% (minimum 99%, Missing); skin: 32.1663% (minimum 95%, Missing)",0,2,partial,0.6,53.6,62,"skin: 62 nTPM (manageable, limit 5); esophagus: 53.6 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 4)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000154227,CERS3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.628337,-0.615783,-0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000154438,ASZ1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000154438,ASZ1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000154438,ASZ1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,45.9,1.5,3.3,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 2); bone marrow: 3.6 nTPM (vital, limit 2); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000154479,CFAP210,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.9309% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.1100% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.5774% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.2264% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.8941% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.6472% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.7625% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8564% (minimum 99%, Baseline (adaptation disabled)); lung: 97.0075% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.9849% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2323% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.8867% (minimum 99%, Baseline (adaptation disabled)); retina: 92.2894% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.9849% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,45.9,1.5,3.3,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000154479,CFAP210,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.00930949,0.0110845,-0.361059
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.9309% (minimum 99%, Missing); basal ganglia: 95.1100% (minimum 99%, Missing); bone marrow: 95.5774% (minimum 98%, Approved); cerebral cortex: 95.2264% (minimum 98%, Approved); choroid plexus: 62.8941% (minimum 99%, Missing); hippocampal formation: 94.6472% (minimum 99%, Missing); hypothalamus: 94.7625% (minimum 99%, Missing); lung: 97.0075% (minimum 98%, Approved); midbrain: 97.9849% (minimum 99%, Missing); pancreas: 98.2323% (minimum 99%, Missing); pituitary gland: 96.8867% (minimum 99%, Missing); retina: 92.2894% (minimum 99%, Missing); spinal cord: 97.9849% (minimum 99%, Missing)",0,6,partial,45.9,1.5,3.3,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 2); bone marrow: 3.6 nTPM (vital, limit 2); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000154479,CFAP210,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0474359,0.0274359,-0.361059
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,4.2,1.5,1.2,"cerebral cortex: 4.2 nTPM (vital, limit 2); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 2); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154548,SRSF12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.5217% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.0833% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.5217% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.5517% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.5490% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.6897% (minimum 99%, Baseline (adaptation disabled)); colon: 94.8718% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.5217% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.7234% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.7188% (minimum 99%, Baseline (adaptation disabled)); liver: 97.3684% (minimum 99%, Baseline (adaptation disabled)); lung: 96.5217% (minimum 99%, Baseline (adaptation disabled)); midbrain: 86.0465% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.8718% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.0952% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 81.6176% (minimum 99%, Baseline (adaptation disabled)); retina: 82.8358% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.2301% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2301% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.7355% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.5217% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 90.2439% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.0678% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,4.2,1.5,1.2,"cerebral cortex: 4.2 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154548,SRSF12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.047561,-0.0890476,-0.26451
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.5217% (minimum 98%, Approved); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 77.0833% (minimum 99%, Missing); bone marrow: 96.5217% (minimum 98%, Approved); cerebellum: 76.5517% (minimum 98%, Approved); cerebral cortex: 72.5490% (minimum 98%, Approved); choroid plexus: 95.6897% (minimum 99%, Missing); colon: 94.8718% (minimum 95%, Approved); heart muscle: 96.5217% (minimum 98%, Approved); hippocampal formation: 78.7234% (minimum 99%, Missing); hypothalamus: 74.0000% (minimum 99%, Missing); kidney: 86.7188% (minimum 98%, Approved); liver: 97.3684% (minimum 98%, Approved); lung: 96.5217% (minimum 98%, Approved); midbrain: 86.0465% (minimum 99%, Missing); pancreas: 94.8718% (minimum 98%, Approved); parathyroid gland: 88.0952% (minimum 97%, Missing); pituitary gland: 81.6176% (minimum 99%, Missing); retina: 82.8358% (minimum 99%, Missing); smooth muscle: 92.5000% (minimum 98%, Approved); spinal cord: 91.7355% (minimum 99%, Missing); urinary bladder: 94.0678% (minimum 95%, Approved)",0,3,partial,4.2,1.5,1.2,"cerebral cortex: 4.2 nTPM (vital, limit 2); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 2); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154548,SRSF12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00243902,-0.0890476,-0.25451
True,compatible,,True,True,False,,0,80,unavailable,0.1,1.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000154611,PSMA8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 92.6554% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.1,1.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000154611,PSMA8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0204142,-0.0434463,0.00393939
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 92.6554% (minimum 97%, Missing)",0,80,unavailable,0.1,1.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000154611,PSMA8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0204142,-0.0434463,0.00393939
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,7.9,3.4,13.7,"hypothalamus: 7.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154645,CHODL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.3904% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.7695% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.4110% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.7695% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.7273% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.4744% (minimum 99%, Baseline (adaptation disabled)); colon: 91.7683% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.9527% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 89.5833% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.1661% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.2105% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.5833% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.8599% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.6154% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.8507% (minimum 97%, Baseline (adaptation disabled)); retina: 98.0456% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.0456% (minimum 99%, Baseline (adaptation disabled)); skin: 93.1889% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.0968% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.1889% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.7215% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.9527% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,7.9,3.4,13.7,"spleen: 13.7 nTPM (manageable, limit 5); hypothalamus: 7.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154645,CHODL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.262785,-0.0714925,-0.197895
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.7695% (minimum 95%, Enhanced); amygdala: 97.4110% (minimum 99%, Missing); basal ganglia: 93.7695% (minimum 99%, Missing); choroid plexus: 96.4744% (minimum 99%, Missing); colon: 91.7683% (minimum 97%, Missing); duodenum: 94.9527% (minimum 99%, Missing); heart muscle: 89.5833% (minimum 95%, Enhanced); hippocampal formation: 96.1661% (minimum 99%, Missing); hypothalamus: 79.2105% (minimum 99%, Missing); kidney: 89.5833% (minimum 95%, Enhanced); midbrain: 95.8599% (minimum 99%, Missing); pituitary gland: 92.6154% (minimum 99%, Missing); rectum: 89.8507% (minimum 97%, Missing); retina: 98.0456% (minimum 99%, Missing); small intestine: 97.0968% (minimum 99%, Missing); spinal cord: 93.1889% (minimum 99%, Missing); tongue: 94.9527% (minimum 97%, Missing)",0,2,partial,7.9,3.4,13.7,"hypothalamus: 7.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154645,CHODL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0401316,-0.0714925,-0.197895
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,8.5,8.2,7,"liver: 8.5 nTPM (vital, limit 2); parathyroid gland: 8.2 nTPM (protected, limit 4); skin: 7 nTPM (manageable, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); heart muscle: 4.8 nTPM (vital, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 2); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); stomach: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000154655,L3MBTL4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.9211% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.5455% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.8462% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.5503% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.7810% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.6190% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.3548% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.8276% (minimum 99%, Baseline (adaptation disabled)); colon: 86.0140% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.9211% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.3439% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.9298% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.8481% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.6735% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.0625% (minimum 99%, Baseline (adaptation disabled)); liver: 59.1346% (minimum 99%, Baseline (adaptation disabled)); lung: 76.8750% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.6197% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.3548% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.1290% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 79.8701% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.6197% (minimum 97%, Baseline (adaptation disabled)); retina: 88.4892% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.3548% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.1818% (minimum 99%, Baseline (adaptation disabled)); skin: 63.7306% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.3439% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.1111% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.2466% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.4570% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.8701% (minimum 97%, Baseline (adaptation disabled)); thymus: 81.4570% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.7151% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.4412% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.7810% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,8.5,8.2,7,"liver: 8.5 nTPM (vital, limit 1); parathyroid gland: 8.2 nTPM (protected, limit 2); skin: 7 nTPM (manageable, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 2); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); stomach: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000154655,L3MBTL4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.312694,-0.37,-0.398654
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.9211% (minimum 90%, Approved); adrenal gland: 74.5455% (minimum 99%, Missing); amygdala: 78.8462% (minimum 99%, Missing); basal ganglia: 82.5503% (minimum 99%, Missing); bone marrow: 89.7810% (minimum 99%, Missing); cerebellum: 97.6190% (minimum 99%, Missing); cerebral cortex: 79.3548% (minimum 99%, Missing); choroid plexus: 84.8276% (minimum 99%, Missing); colon: 86.0140% (minimum 97%, Missing); duodenum: 80.9211% (minimum 98%, Approved); esophagus: 78.3439% (minimum 97%, Missing); heart muscle: 71.9298% (minimum 98%, Approved); hippocampal formation: 77.8481% (minimum 99%, Missing); hypothalamus: 83.6735% (minimum 99%, Missing); kidney: 64.0625% (minimum 99%, Missing); liver: 59.1346% (minimum 98%, Approved); lung: 76.8750% (minimum 99%, Missing); lymph node: 86.6197% (minimum 97%, Missing); midbrain: 79.3548% (minimum 99%, Missing); pancreas: 66.1290% (minimum 99%, Missing); parathyroid gland: 60.0000% (minimum 95%, Approved); pituitary gland: 79.8701% (minimum 99%, Missing); rectum: 86.6197% (minimum 95%, Approved); retina: 88.4892% (minimum 99%, Missing); salivary gland: 79.3548% (minimum 97%, Missing); skeletal muscle: 93.1818% (minimum 99%, Missing); skin: 63.7306% (minimum 95%, Missing); small intestine: 78.3439% (minimum 99%, Missing); smooth muscle: 91.1111% (minimum 99%, Missing); spinal cord: 84.2466% (minimum 99%, Missing); spleen: 81.4570% (minimum 90%, Approved); stomach: 79.8701% (minimum 97%, Missing); thymus: 81.4570% (minimum 95%, Missing); thyroid gland: 68.7151% (minimum 95%, Missing); tongue: 90.4412% (minimum 97%, Missing); urinary bladder: 89.7810% (minimum 97%, Missing)",0,2,partial,8.5,8.2,7,"liver: 8.5 nTPM (vital, limit 2); parathyroid gland: 8.2 nTPM (protected, limit 4); skin: 7 nTPM (manageable, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); heart muscle: 4.8 nTPM (vital, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 2); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); stomach: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000154655,L3MBTL4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.312694,-0.35,-0.388654
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,76,19.2,23.3,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); skin: 23.3 nTPM (manageable, limit 5); esophagus: 19.2 nTPM (protected, limit 2); urinary bladder: 18.5 nTPM (protected, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 5); thyroid gland: 15.6 nTPM (manageable, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); thymus: 13 nTPM (manageable, limit 5); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 2); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 2); lymph node: 11.4 nTPM (protected, limit 2); kidney: 11.2 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 2); lung: 10.3 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 2); heart muscle: 9.6 nTPM (vital, limit 1); spleen: 9.5 nTPM (manageable, limit 5); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); salivary gland: 8.5 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154710,RABGEF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.0422% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.0625% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.6117% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 24.4533% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.4255% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.3073% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.5669% (minimum 99%, Baseline (adaptation disabled)); colon: 70.0855% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.9259% (minimum 99%, Baseline (adaptation disabled)); esophagus: 56.1644% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.9298% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.6557% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.9259% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.7151% (minimum 99%, Baseline (adaptation disabled)); liver: 62.7551% (minimum 99%, Baseline (adaptation disabled)); lung: 70.4871% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.3898% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.3529% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.0769% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.1211% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.9558% (minimum 97%, Baseline (adaptation disabled)); retina: 33.6525% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.3202% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.7754% (minimum 99%, Baseline (adaptation disabled)); skin: 51.3570% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.2143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.2131% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.6735% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.1408% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.4871% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.4255% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.1940% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.6000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.0766% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,76,19.2,23.3,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); skin: 23.3 nTPM (manageable, limit 5); esophagus: 19.2 nTPM (protected, limit 2); urinary bladder: 18.5 nTPM (protected, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 5); thyroid gland: 15.6 nTPM (manageable, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); thymus: 13 nTPM (manageable, limit 5); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 2); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 2); lymph node: 11.4 nTPM (protected, limit 2); kidney: 11.2 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 2); lung: 10.3 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 2); heart muscle: 9.6 nTPM (vital, limit 1); spleen: 9.5 nTPM (manageable, limit 5); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); salivary gland: 8.5 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154710,RABGEF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.43643,-0.408356,-0.745467
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.0422% (minimum 95%, Missing); adrenal gland: 64.0625% (minimum 99%, Missing); amygdala: 82.0000% (minimum 99%, Missing); basal ganglia: 79.6117% (minimum 99%, Missing); bone marrow: 24.4533% (minimum 99%, Missing); cerebellum: 65.4255% (minimum 99%, Missing); cerebral cortex: 66.3073% (minimum 99%, Missing); choroid plexus: 64.5669% (minimum 99%, Missing); colon: 70.0855% (minimum 97%, Missing); duodenum: 75.9259% (minimum 99%, Missing); esophagus: 56.1644% (minimum 97%, Missing); heart muscle: 71.9298% (minimum 99%, Missing); hippocampal formation: 80.6557% (minimum 99%, Missing); hypothalamus: 75.9259% (minimum 99%, Missing); kidney: 68.7151% (minimum 99%, Missing); liver: 62.7551% (minimum 99%, Missing); lung: 70.4871% (minimum 99%, Missing); lymph node: 68.3333% (minimum 97%, Missing); midbrain: 83.3898% (minimum 99%, Missing); pancreas: 72.3529% (minimum 99%, Missing); parathyroid gland: 63.0769% (minimum 97%, Missing); pituitary gland: 85.1211% (minimum 99%, Missing); rectum: 67.9558% (minimum 97%, Missing); retina: 33.6525% (minimum 99%, Missing); salivary gland: 74.3202% (minimum 97%, Missing); skeletal muscle: 65.7754% (minimum 99%, Missing); skin: 51.3570% (minimum 95%, Missing); small intestine: 73.2143% (minimum 99%, Missing); smooth muscle: 67.2131% (minimum 99%, Missing); spinal cord: 83.6735% (minimum 99%, Missing); spleen: 72.1408% (minimum 95%, Missing); stomach: 70.4871% (minimum 97%, Missing); thymus: 65.4255% (minimum 95%, Missing); thyroid gland: 61.1940% (minimum 95%, Missing); tongue: 65.6000% (minimum 97%, Missing); urinary bladder: 57.0766% (minimum 97%, Missing)",0,80,unavailable,76,19.2,23.3,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); skin: 23.3 nTPM (manageable, limit 5); esophagus: 19.2 nTPM (protected, limit 2); urinary bladder: 18.5 nTPM (protected, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 5); thyroid gland: 15.6 nTPM (manageable, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); thymus: 13 nTPM (manageable, limit 5); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 2); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 2); lymph node: 11.4 nTPM (protected, limit 2); kidney: 11.2 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 2); lung: 10.3 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 2); heart muscle: 9.6 nTPM (vital, limit 1); spleen: 9.5 nTPM (manageable, limit 5); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); salivary gland: 8.5 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154710,RABGEF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.43643,-0.408356,-0.745467
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,18.7,19.9,21.5,"thymus: 21.5 nTPM (manageable, limit 5); thyroid gland: 20.6 nTPM (manageable, limit 5); lymph node: 19.9 nTPM (protected, limit 2); liver: 18.7 nTPM (vital, limit 3); spleen: 18.2 nTPM (manageable, limit 5); adipose tissue: 16.4 nTPM (manageable, limit 5); tongue: 15.9 nTPM (protected, limit 2); bone marrow: 15.8 nTPM (vital, limit 3); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 2); adrenal gland: 13.4 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 2); kidney: 13.3 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 2); heart muscle: 12.5 nTPM (vital, limit 3); colon: 12.1 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 2); skeletal muscle: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); skin: 10 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 3); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154727,GABPA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1022% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.8814% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.2642% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.1481% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.0625% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.6025% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.4340% (minimum 99%, Baseline (adaptation disabled)); colon: 66.2011% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.2893% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.4971% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.4696% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.7375% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.7241% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.0541% (minimum 99%, Baseline (adaptation disabled)); liver: 55.8962% (minimum 99%, Baseline (adaptation disabled)); lung: 64.7541% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.3578% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.7049% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.5357% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.5584% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.4768% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.0541% (minimum 97%, Baseline (adaptation disabled)); retina: 68.1034% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.1183% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.9115% (minimum 99%, Baseline (adaptation disabled)); skin: 70.3264% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.5777% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.5584% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.1481% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.5632% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.3295% (minimum 97%, Baseline (adaptation disabled)); thymus: 52.4336% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.4989% (minimum 95%, Baseline (adaptation disabled)); tongue: 59.8485% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.4696% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,18.7,19.9,21.5,"thymus: 21.5 nTPM (manageable, limit 5); thyroid gland: 20.6 nTPM (manageable, limit 5); lymph node: 19.9 nTPM (protected, limit 2); liver: 18.7 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); adipose tissue: 16.4 nTPM (manageable, limit 5); tongue: 15.9 nTPM (protected, limit 2); bone marrow: 15.8 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 2); adrenal gland: 13.4 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 2); kidney: 13.3 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 2); heart muscle: 12.5 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 2); skeletal muscle: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); skin: 10 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154727,GABPA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.425664,-0.426422,-0.431038
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1022% (minimum 95%, Missing); adrenal gland: 63.8814% (minimum 99%, Missing); amygdala: 79.2642% (minimum 99%, Missing); basal ganglia: 73.1481% (minimum 99%, Missing); bone marrow: 60.0000% (minimum 97%, Supported); cerebellum: 74.0625% (minimum 97%, Supported); cerebral cortex: 73.6025% (minimum 99%, Missing); choroid plexus: 89.4340% (minimum 99%, Missing); colon: 66.2011% (minimum 97%, Missing); duodenum: 65.2893% (minimum 99%, Missing); esophagus: 68.4971% (minimum 97%, Missing); heart muscle: 65.4696% (minimum 97%, Supported); hippocampal formation: 78.7375% (minimum 99%, Missing); hypothalamus: 81.7241% (minimum 99%, Missing); kidney: 64.0541% (minimum 99%, Missing); liver: 55.8962% (minimum 97%, Supported); lung: 64.7541% (minimum 99%, Missing); lymph node: 54.3578% (minimum 97%, Missing); midbrain: 77.7049% (minimum 99%, Missing); pancreas: 70.5357% (minimum 99%, Missing); parathyroid gland: 61.5584% (minimum 97%, Missing); pituitary gland: 78.4768% (minimum 99%, Missing); rectum: 64.0541% (minimum 97%, Missing); retina: 68.1034% (minimum 99%, Missing); salivary gland: 70.1183% (minimum 97%, Missing); skeletal muscle: 69.9115% (minimum 99%, Missing); skin: 70.3264% (minimum 95%, Missing); small intestine: 64.5777% (minimum 99%, Missing); smooth muscle: 61.5584% (minimum 99%, Missing); spinal cord: 73.1481% (minimum 99%, Missing); spleen: 56.5632% (minimum 95%, Missing); stomach: 67.3295% (minimum 97%, Missing); thymus: 52.4336% (minimum 95%, Missing); thyroid gland: 53.4989% (minimum 95%, Missing); tongue: 59.8485% (minimum 97%, Missing); urinary bladder: 65.4696% (minimum 97%, Missing)",0,2,partial,18.7,19.9,21.5,"thymus: 21.5 nTPM (manageable, limit 5); thyroid gland: 20.6 nTPM (manageable, limit 5); lymph node: 19.9 nTPM (protected, limit 2); liver: 18.7 nTPM (vital, limit 3); spleen: 18.2 nTPM (manageable, limit 5); adipose tissue: 16.4 nTPM (manageable, limit 5); tongue: 15.9 nTPM (protected, limit 2); bone marrow: 15.8 nTPM (vital, limit 3); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 2); adrenal gland: 13.4 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 2); kidney: 13.3 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 2); heart muscle: 12.5 nTPM (vital, limit 3); colon: 12.1 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 2); skeletal muscle: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); skin: 10 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 3); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154727,GABPA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.425664,-0.426422,-0.411038
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,4,0.4,1.2,"cerebral cortex: 4 nTPM (vital, limit 2); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; tonsil,ENSG00000154764,WNT7A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 41.2698% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 44.8276% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.2963% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.8710% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 39.3939% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.2963% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.6667% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 61.9048% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.8571% (minimum 99%, Baseline (adaptation disabled)); lung: 56.5217% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.8571% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.4146% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.2963% (minimum 99%, Baseline (adaptation disabled)); skin: 74.2857% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 74.2857% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.4211% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 89.6552% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,4,0.4,1.2,"cerebral cortex: 4 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; tonsil,ENSG00000154764,WNT7A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.265789,-0.103333,-0.596061
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 41.2698% (minimum 99%, Missing); basal ganglia: 44.8276% (minimum 99%, Missing); bone marrow: 96.2963% (minimum 98%, Approved); cerebellum: 83.8710% (minimum 98%, Approved); cerebral cortex: 39.3939% (minimum 98%, Approved); choroid plexus: 96.2963% (minimum 99%, Missing); esophagus: 86.6667% (minimum 95%, Approved); hippocampal formation: 61.9048% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 92.8571% (minimum 98%, Approved); lung: 56.5217% (minimum 98%, Approved); lymph node: 92.8571% (minimum 95%, Approved); midbrain: 63.4146% (minimum 99%, Missing); pancreas: 96.2963% (minimum 98%, Approved); skin: 74.2857% (minimum 90%, Approved); spinal cord: 74.2857% (minimum 99%, Missing); spleen: 68.4211% (minimum 90%, Approved); urinary bladder: 89.6552% (minimum 95%, Approved)",0,1,partial,4,0.4,1.2,"cerebral cortex: 4 nTPM (vital, limit 2); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; tonsil,ENSG00000154764,WNT7A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.215789,-0.0833333,-0.586061
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,11.8,4.7,3.5,"bone marrow: 11.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154839,SKA1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.1111% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.1304% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 25.7862% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.4167% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.1818% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.1818% (minimum 99%, Baseline (adaptation disabled)); colon: 71.9298% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.6897% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.1212% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.3488% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.6190% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.6190% (minimum 99%, Baseline (adaptation disabled)); liver: 93.1818% (minimum 99%, Baseline (adaptation disabled)); lung: 93.1818% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.5909% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.6190% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.1111% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.2131% (minimum 97%, Baseline (adaptation disabled)); retina: 93.1818% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.1818% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.1304% (minimum 99%, Baseline (adaptation disabled)); skin: 73.2143% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.9259% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.8462% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.6190% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.9259% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.6735% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.9474% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.1818% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.3488% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.1304% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,11.8,4.7,3.5,"bone marrow: 11.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154839,SKA1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.410526,-0.504091,-0.732138
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.1111% (minimum 95%, Missing); adrenal gland: 89.1304% (minimum 99%, Missing); bone marrow: 25.7862% (minimum 99%, Missing); cerebellum: 85.4167% (minimum 99%, Missing); cerebral cortex: 93.1818% (minimum 99%, Missing); choroid plexus: 93.1818% (minimum 99%, Missing); colon: 71.9298% (minimum 97%, Missing); duodenum: 70.6897% (minimum 99%, Missing); esophagus: 62.1212% (minimum 97%, Missing); heart muscle: 95.3488% (minimum 99%, Missing); hypothalamus: 97.6190% (minimum 99%, Missing); kidney: 97.6190% (minimum 99%, Missing); liver: 93.1818% (minimum 99%, Missing); lung: 93.1818% (minimum 99%, Missing); lymph node: 46.5909% (minimum 97%, Missing); midbrain: 97.6190% (minimum 99%, Missing); pancreas: 91.1111% (minimum 99%, Missing); rectum: 67.2131% (minimum 97%, Missing); retina: 93.1818% (minimum 99%, Missing); salivary gland: 93.1818% (minimum 97%, Missing); skeletal muscle: 89.1304% (minimum 99%, Missing); skin: 73.2143% (minimum 95%, Missing); small intestine: 75.9259% (minimum 99%, Missing); smooth muscle: 78.8462% (minimum 99%, Missing); spinal cord: 97.6190% (minimum 99%, Missing); spleen: 75.9259% (minimum 90%, Approved); stomach: 83.6735% (minimum 97%, Missing); thymus: 53.9474% (minimum 95%, Missing); thyroid gland: 93.1818% (minimum 95%, Missing); tongue: 95.3488% (minimum 97%, Missing); urinary bladder: 89.1304% (minimum 97%, Missing)",0,3,partial,11.8,4.7,3.5,"bone marrow: 11.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154839,SKA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.410526,-0.504091,-0.732138
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,4.3,2.2,3.2,"bone marrow: 4.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154920,EME1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.5373% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.3846% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.8750% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.8750% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.0476% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.4127% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.3846% (minimum 99%, Baseline (adaptation disabled)); colon: 87.3239% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.8551% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.1111% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.8750% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.3846% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.4127% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.8750% (minimum 99%, Baseline (adaptation disabled)); liver: 93.9394% (minimum 99%, Baseline (adaptation disabled)); lung: 93.9394% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.8095% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.8750% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.8750% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.4127% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.7838% (minimum 97%, Baseline (adaptation disabled)); retina: 93.9394% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.9394% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.8750% (minimum 99%, Baseline (adaptation disabled)); skin: 86.1111% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.8551% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.1765% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.3846% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.3239% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.9394% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.9574% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.9394% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,4.3,2.2,3.2,"bone marrow: 4.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154920,EME1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.290426,-0.231905,-0.399524
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.5373% (minimum 95%, Missing); adrenal gland: 95.3846% (minimum 99%, Missing); amygdala: 96.8750% (minimum 99%, Missing); basal ganglia: 96.8750% (minimum 99%, Missing); bone marrow: 59.0476% (minimum 99%, Missing); cerebellum: 98.4127% (minimum 99%, Missing); cerebral cortex: 95.3846% (minimum 99%, Missing); colon: 87.3239% (minimum 97%, Missing); duodenum: 89.8551% (minimum 99%, Missing); esophagus: 86.1111% (minimum 97%, Missing); heart muscle: 96.8750% (minimum 99%, Missing); hippocampal formation: 95.3846% (minimum 99%, Missing); hypothalamus: 98.4127% (minimum 99%, Missing); kidney: 96.8750% (minimum 99%, Missing); liver: 93.9394% (minimum 99%, Missing); lung: 93.9394% (minimum 99%, Missing); lymph node: 73.8095% (minimum 97%, Missing); midbrain: 96.8750% (minimum 99%, Missing); pancreas: 96.8750% (minimum 99%, Missing); pituitary gland: 98.4127% (minimum 99%, Missing); rectum: 83.7838% (minimum 97%, Missing); retina: 93.9394% (minimum 99%, Missing); salivary gland: 93.9394% (minimum 97%, Missing); skeletal muscle: 96.8750% (minimum 99%, Missing); skin: 86.1111% (minimum 95%, Missing); small intestine: 89.8551% (minimum 99%, Missing); smooth muscle: 91.1765% (minimum 99%, Missing); spinal cord: 95.3846% (minimum 99%, Missing); spleen: 87.3239% (minimum 95%, Missing); stomach: 93.9394% (minimum 97%, Missing); thymus: 65.9574% (minimum 95%, Missing); urinary bladder: 93.9394% (minimum 97%, Missing)",0,2,partial,4.3,2.2,3.2,"bone marrow: 4.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154920,EME1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.290426,-0.231905,-0.399524
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,9,partial,20.2,9.9,6.8,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 6); tongue: 9.9 nTPM (protected, limit 2); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154928,EPHB1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.0354% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.4128% (minimum 99%, Baseline (adaptation disabled)); amygdala: 58.7571% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 41.2698% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.5455% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 33.9869% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 43.5146% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.1963% (minimum 99%, Baseline (adaptation disabled)); colon: 77.0370% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.5528% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.1963% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.0968% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.7273% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.8889% (minimum 99%, Baseline (adaptation disabled)); liver: 87.3950% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1132% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.5528% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.3950% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.1963% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.0354% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.4128% (minimum 97%, Baseline (adaptation disabled)); retina: 72.2222% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.5397% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.8742% (minimum 99%, Baseline (adaptation disabled)); skin: 69.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.6937% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.6937% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.1356% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.5455% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.5455% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.4651% (minimum 95%, Baseline (adaptation disabled)); tongue: 51.2315% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.1356% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,20.2,9.9,6.8,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); liver: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154928,EPHB1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.345349,-0.457685,-0.650131
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.7571% (minimum 99%, Missing); basal ganglia: 41.2698% (minimum 99%, Missing); bone marrow: 94.5455% (minimum 95%, Enhanced); cerebellum: 33.9869% (minimum 99%, Missing); cerebral cortex: 43.5146% (minimum 95%, Enhanced); choroid plexus: 97.1963% (minimum 99%, Missing); colon: 77.0370% (minimum 97%, Missing); duodenum: 88.8889% (minimum 95%, Enhanced); hippocampal formation: 67.0968% (minimum 99%, Missing); hypothalamus: 72.7273% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 87.3950% (minimum 95%, Enhanced); midbrain: 87.3950% (minimum 99%, Missing); pituitary gland: 92.0354% (minimum 99%, Missing); retina: 72.2222% (minimum 99%, Missing); skeletal muscle: 68.8742% (minimum 95%, Enhanced); small intestine: 93.6937% (minimum 95%, Enhanced); smooth muscle: 93.6937% (minimum 95%, Enhanced); spinal cord: 88.1356% (minimum 99%, Missing); stomach: 94.5455% (minimum 97%, Missing); thymus: 94.5455% (minimum 95%, Missing); thyroid gland: 60.4651% (minimum 95%, Missing); tongue: 51.2315% (minimum 97%, Missing); urinary bladder: 88.1356% (minimum 97%, Missing)",0,9,partial,20.2,9.9,6.8,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 6); tongue: 9.9 nTPM (protected, limit 2); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000154928,EPHB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.345349,-0.457685,-0.650131
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,2.3,1.1,1.4,"retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154997,SEPTIN14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.3451% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.5350% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.4912% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.6547% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.7778% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.9163% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.3451% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.6522% (minimum 99%, Baseline (adaptation disabled)); liver: 90.9091% (minimum 99%, Baseline (adaptation disabled)); lung: 96.9163% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.6522% (minimum 97%, Baseline (adaptation disabled)); pancreas: 97.7778% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.2381% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.4206% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.9163% (minimum 97%, Baseline (adaptation disabled)); retina: 91.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.4912% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.3451% (minimum 99%, Baseline (adaptation disabled)); skin: 94.0171% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.7778% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.9163% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.8276% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.0699% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.8276% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.8276% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.4912% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,2.3,1.1,1.4,"bone marrow: 2.3 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154997,SEPTIN14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,-0.00982906,-0.017619,-0.0846502
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.5350% (minimum 95%, Enhanced); choroid plexus: 98.6547% (minimum 99%, Missing); liver: 90.9091% (minimum 95%, Enhanced); pituitary gland: 94.4206% (minimum 99%, Missing); retina: 91.6667% (minimum 99%, Missing); thymus: 94.8276% (minimum 95%, Missing)",0,3,partial,2.3,1.1,1.4,"retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000154997,SEPTIN14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,-0.00172414,0.00777778,-0.0733333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,4.2,0.9,1,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000155026,RSPH10B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.4615% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.5813% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.2039% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.4619% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.9592% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.0513% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.3077% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.3077% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.9691% (minimum 99%, Baseline (adaptation disabled)); liver: 97.9592% (minimum 99%, Baseline (adaptation disabled)); lung: 93.2039% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.9592% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.5224% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.5813% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4615% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.9691% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4619% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,4.2,0.9,1,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000155026,RSPH10B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.00049505,-0.0147761,-0.169487
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 94.5813% (minimum 99%, Missing); basal ganglia: 93.2039% (minimum 99%, Missing); choroid plexus: 82.0513% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); lung: 93.2039% (minimum 97%, Supported); midbrain: 97.9592% (minimum 99%, Missing); pituitary gland: 94.5813% (minimum 99%, Missing); retina: 98.4615% (minimum 99%, Missing); spinal cord: 97.4619% (minimum 99%, Missing)",0,4,partial,4.2,0.9,1,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000155026,RSPH10B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,0.0248187,-0.169487
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,15.5,8.8,7.3,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 2); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); colon: 4.4 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); lymph node: 4 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); urinary bladder: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000155085,AK9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.5641% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.2932% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.0335% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.5869% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.3131% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.8532% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 50.9494% (minimum 99%, Baseline (adaptation disabled)); colon: 78.5366% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.1429% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.7030% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.4038% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.8532% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.6140% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.9434% (minimum 99%, Baseline (adaptation disabled)); liver: 84.2932% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0995% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0995% (minimum 97%, Baseline (adaptation disabled)); midbrain: 72.1973% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.9897% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.6586% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.2203% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.3103% (minimum 97%, Baseline (adaptation disabled)); retina: 54.2088% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.3033% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.7778% (minimum 99%, Baseline (adaptation disabled)); skin: 80.9045% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.5641% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.3131% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.5106% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.5366% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.8034% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.9251% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.5641% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.9897% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,15.5,8.8,7.3,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 2); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); colon: 4.4 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); lymph node: 4 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); urinary bladder: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000155085,AK9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.261966,-0.323414,-0.480506
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.5641% (minimum 95%, Missing); adrenal gland: 84.2932% (minimum 99%, Missing); amygdala: 77.0335% (minimum 99%, Missing); basal ganglia: 75.5869% (minimum 99%, Missing); bone marrow: 81.3131% (minimum 99%, Missing); cerebellum: 73.8532% (minimum 99%, Missing); cerebral cortex: 76.6667% (minimum 99%, Missing); choroid plexus: 50.9494% (minimum 99%, Missing); colon: 78.5366% (minimum 97%, Missing); duodenum: 82.1429% (minimum 99%, Missing); esophagus: 79.7030% (minimum 97%, Missing); heart muscle: 77.4038% (minimum 99%, Missing); hippocampal formation: 73.8532% (minimum 99%, Missing); hypothalamus: 70.6140% (minimum 99%, Missing); kidney: 75.9434% (minimum 99%, Missing); liver: 84.2932% (minimum 99%, Missing); lung: 80.0995% (minimum 99%, Missing); lymph node: 80.0995% (minimum 97%, Missing); midbrain: 72.1973% (minimum 99%, Missing); pancreas: 82.9897% (minimum 99%, Missing); parathyroid gland: 64.6586% (minimum 97%, Missing); pituitary gland: 68.2203% (minimum 99%, Missing); rectum: 79.3103% (minimum 97%, Missing); retina: 54.2088% (minimum 99%, Missing); salivary gland: 76.3033% (minimum 97%, Missing); skeletal muscle: 77.7778% (minimum 99%, Missing); skin: 80.9045% (minimum 95%, Missing); small intestine: 82.5641% (minimum 99%, Missing); smooth muscle: 81.3131% (minimum 99%, Missing); spinal cord: 68.5106% (minimum 99%, Missing); spleen: 80.5000% (minimum 95%, Missing); stomach: 78.5366% (minimum 97%, Missing); thymus: 68.8034% (minimum 95%, Missing); thyroid gland: 70.9251% (minimum 95%, Missing); tongue: 82.5641% (minimum 97%, Missing); urinary bladder: 82.9897% (minimum 97%, Missing)",0,2,partial,15.5,8.8,7.3,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 2); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); colon: 4.4 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); lymph node: 4 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); urinary bladder: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000155085,AK9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.261966,-0.323414,-0.480506
True,compatible,,True,True,False,,0,1,partial,0.7,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000155087,ODF1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.7,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000155087,ODF1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.049741,0.029741,0.00818981
True,compatible,,True,True,True,,0,1,partial,0.7,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000155087,ODF1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00818981
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000155249,OR4K1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000155249,OR4K1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000155249,OR4K1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,116.3,72.7,24.9,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 2); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); thymus: 24.9 nTPM (manageable, limit 5); adipose tissue: 24.6 nTPM (manageable, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 2); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 2); liver: 19.4 nTPM (vital, limit 1); spleen: 18.6 nTPM (manageable, limit 5); salivary gland: 16.8 nTPM (protected, limit 2); rectum: 15.6 nTPM (protected, limit 2); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); urinary bladder: 14.9 nTPM (protected, limit 2); colon: 14.8 nTPM (protected, limit 2); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 2); small intestine: 13 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); skin: 12.6 nTPM (manageable, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000155313,USP25,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.0934% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.7692% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.3982% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.4336% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.2043% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.2353% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.3582% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.0891% (minimum 99%, Baseline (adaptation disabled)); colon: 78.0089% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.0185% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.4286% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.8720% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.1527% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.9178% (minimum 99%, Baseline (adaptation disabled)); liver: 73.0181% (minimum 99%, Baseline (adaptation disabled)); lung: 69.5364% (minimum 99%, Baseline (adaptation disabled)); lymph node: 72.8155% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.9247% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.3196% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.3051% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.6461% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.0925% (minimum 97%, Baseline (adaptation disabled)); retina: 84.9515% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.7576% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 31.1019% (minimum 99%, Baseline (adaptation disabled)); skin: 80.6452% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.1527% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.8632% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.6774% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.8397% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.5215% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.8295% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 77.7778% (minimum 95%, Baseline (adaptation disabled)); tongue: 41.9329% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.8932% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,116.3,72.7,24.9,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 2); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); thymus: 24.9 nTPM (manageable, limit 5); adipose tissue: 24.6 nTPM (manageable, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 2); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 2); liver: 19.4 nTPM (vital, limit 1); spleen: 18.6 nTPM (manageable, limit 5); salivary gland: 16.8 nTPM (protected, limit 2); rectum: 15.6 nTPM (protected, limit 2); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); urinary bladder: 14.9 nTPM (protected, limit 2); colon: 14.8 nTPM (protected, limit 2); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 2); small intestine: 13 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); skin: 12.6 nTPM (manageable, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000155313,USP25,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.271705,-0.550671,-0.678981
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.0934% (minimum 95%, Missing); adrenal gland: 80.7692% (minimum 99%, Missing); amygdala: 80.3982% (minimum 99%, Missing); basal ganglia: 77.4336% (minimum 99%, Missing); bone marrow: 66.2043% (minimum 99%, Missing); cerebellum: 88.2353% (minimum 99%, Missing); cerebral cortex: 78.3582% (minimum 99%, Missing); choroid plexus: 85.0891% (minimum 99%, Missing); colon: 78.0089% (minimum 97%, Missing); duodenum: 81.0185% (minimum 99%, Missing); esophagus: 71.4286% (minimum 97%, Missing); heart muscle: 65.8720% (minimum 99%, Missing); hippocampal formation: 80.1527% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); kidney: 71.9178% (minimum 99%, Missing); liver: 73.0181% (minimum 99%, Missing); lung: 69.5364% (minimum 99%, Missing); lymph node: 72.8155% (minimum 97%, Missing); midbrain: 85.9247% (minimum 99%, Missing); pancreas: 77.3196% (minimum 99%, Missing); parathyroid gland: 79.3051% (minimum 97%, Missing); pituitary gland: 87.6461% (minimum 99%, Missing); rectum: 77.0925% (minimum 97%, Missing); retina: 84.9515% (minimum 99%, Missing); salivary gland: 75.7576% (minimum 97%, Missing); skeletal muscle: 31.1019% (minimum 99%, Missing); skin: 80.6452% (minimum 95%, Missing); small intestine: 80.1527% (minimum 99%, Missing); smooth muscle: 59.8632% (minimum 99%, Missing); spinal cord: 84.6774% (minimum 99%, Missing); spleen: 73.8397% (minimum 95%, Missing); stomach: 80.5215% (minimum 97%, Missing); thymus: 67.8295% (minimum 95%, Missing); thyroid gland: 77.7778% (minimum 95%, Missing); tongue: 41.9329% (minimum 97%, Missing); urinary bladder: 77.8932% (minimum 97%, Missing)",0,0,routine_complete,116.3,72.7,24.9,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 2); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); thymus: 24.9 nTPM (manageable, limit 5); adipose tissue: 24.6 nTPM (manageable, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 2); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 2); liver: 19.4 nTPM (vital, limit 1); spleen: 18.6 nTPM (manageable, limit 5); salivary gland: 16.8 nTPM (protected, limit 2); rectum: 15.6 nTPM (protected, limit 2); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); urinary bladder: 14.9 nTPM (protected, limit 2); colon: 14.8 nTPM (protected, limit 2); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 2); small intestine: 13 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); skin: 12.6 nTPM (manageable, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000155313,USP25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.271705,-0.550671,-0.678981
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,13.2,7.2,3.8,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 2); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 2); adrenal gland: 4.6 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); hippocampal formation: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000155330,C16orf87,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.1776% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.4643% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.6514% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.4237% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.5442% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.9623% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.7447% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.4078% (minimum 99%, Baseline (adaptation disabled)); colon: 82.0276% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.2549% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.8206% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.7899% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.6514% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.5681% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.9163% (minimum 99%, Baseline (adaptation disabled)); liver: 58.3607% (minimum 99%, Baseline (adaptation disabled)); lung: 82.0276% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.1055% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.5769% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.1188% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.7293% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.4074% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 88.5572% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 84.7619% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 57.4194% (minimum 99%, Baseline (adaptation disabled)); skin: 83.1776% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.4643% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.8293% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.7619% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.4074% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.4078% (minimum 97%, Baseline (adaptation disabled)); thymus: 83.1776% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.4078% (minimum 95%, Baseline (adaptation disabled)); tongue: 71.2000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 81.6514% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,13.2,7.2,3.8,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 2); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 2); adrenal gland: 4.6 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); hippocampal formation: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000155330,C16orf87,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.125926,-0.258,-0.415806
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.1776% (minimum 95%, Uncertain); adrenal gland: 79.4643% (minimum 99%, Uncertain); amygdala: 81.6514% (minimum 99%, Missing); basal ganglia: 75.4237% (minimum 99%, Missing); bone marrow: 60.5442% (minimum 99%, Uncertain); cerebellum: 83.9623% (minimum 99%, Missing); cerebral cortex: 75.7447% (minimum 99%, Missing); choroid plexus: 86.4078% (minimum 99%, Missing); colon: 82.0276% (minimum 97%, Uncertain); duodenum: 87.2549% (minimum 99%, Uncertain); esophagus: 79.8206% (minimum 97%, Missing); heart muscle: 74.7899% (minimum 99%, Missing); hippocampal formation: 81.6514% (minimum 99%, Missing); hypothalamus: 83.5681% (minimum 99%, Missing); kidney: 70.9163% (minimum 99%, Missing); liver: 58.3607% (minimum 99%, Uncertain); lung: 82.0276% (minimum 99%, Uncertain); lymph node: 75.1055% (minimum 97%, Uncertain); midbrain: 85.5769% (minimum 99%, Missing); pancreas: 88.1188% (minimum 99%, Uncertain); parathyroid gland: 77.7293% (minimum 97%, Uncertain); pituitary gland: 82.4074% (minimum 99%, Missing); rectum: 89.0000% (minimum 97%, Missing); retina: 88.5572% (minimum 99%, Missing); salivary gland: 84.7619% (minimum 97%, Uncertain); skeletal muscle: 57.4194% (minimum 99%, Missing); skin: 83.1776% (minimum 95%, Missing); small intestine: 79.4643% (minimum 99%, Uncertain); smooth muscle: 86.8293% (minimum 99%, Uncertain); spinal cord: 84.7619% (minimum 99%, Missing); spleen: 82.4074% (minimum 95%, Uncertain); stomach: 86.4078% (minimum 97%, Missing); thymus: 83.1776% (minimum 95%, Missing); thyroid gland: 86.4078% (minimum 95%, Uncertain); tongue: 71.2000% (minimum 97%, Missing); urinary bladder: 81.6514% (minimum 97%, Missing)",0,1,partial,13.2,7.2,3.8,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 2); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 2); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 2); adrenal gland: 4.6 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); hippocampal formation: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000155330,C16orf87,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.125926,-0.258,-0.415806
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,73.1,27.1,19.4,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 2); skin: 19.4 nTPM (manageable, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000155367,PPM1J,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.8269% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.8252% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3735% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.7261% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.6565% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.8836% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.3735% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.0682% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.3994% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.0426% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.2086% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8836% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6378% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.6565% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.9535% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.4843% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.3108% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.1240% (minimum 99%, Baseline (adaptation disabled)); retina: 89.3372% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.8269% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 45.8919% (minimum 99%, Baseline (adaptation disabled)); skin: 76.1671% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.7918% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.7918% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1787% (minimum 99%, Baseline (adaptation disabled)); tongue: 69.5847% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,73.1,27.1,19.4,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 2); skin: 19.4 nTPM (manageable, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000155367,PPM1J,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.188329,-0.274153,-0.531081
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.8269% (minimum 99%, Missing); amygdala: 88.8252% (minimum 99%, Missing); basal ganglia: 93.3735% (minimum 99%, Missing); bone marrow: 98.7261% (minimum 99%, Uncertain); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 88.5714% (minimum 99%, Missing); choroid plexus: 94.6565% (minimum 99%, Missing); duodenum: 98.8836% (minimum 99%, Missing); esophagus: 93.3735% (minimum 97%, Missing); heart muscle: 88.0682% (minimum 99%, Missing); hippocampal formation: 92.3994% (minimum 99%, Missing); hypothalamus: 91.0426% (minimum 99%, Missing); kidney: 89.2086% (minimum 99%, Missing); liver: 98.8836% (minimum 99%, Uncertain); lung: 97.6378% (minimum 99%, Missing); lymph node: 94.6565% (minimum 97%, Missing); midbrain: 92.9535% (minimum 99%, Missing); pancreas: 97.4843% (minimum 99%, Missing); parathyroid gland: 91.3108% (minimum 97%, Missing); pituitary gland: 96.1240% (minimum 99%, Missing); retina: 89.3372% (minimum 99%, Missing); salivary gland: 95.8269% (minimum 97%, Missing); skeletal muscle: 45.8919% (minimum 99%, Missing); skin: 76.1671% (minimum 95%, Missing); small intestine: 97.7918% (minimum 99%, Missing); smooth muscle: 97.7918% (minimum 99%, Uncertain); spinal cord: 97.1787% (minimum 99%, Missing); tongue: 69.5847% (minimum 97%, Missing)",0,6,partial,73.1,27.1,19.4,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 2); skin: 19.4 nTPM (manageable, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000155367,PPM1J,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.188329,-0.274153,-0.531081
True,compatible,,True,True,False,,0,1,partial,0,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000155495,MAGEC1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000155495,MAGEC1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0361111,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000155495,MAGEC1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.2,0.5,0.5,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000155530,LRGUK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.1538% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.1538% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.5926% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.2857% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0392% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.0392% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.9756% (minimum 99%, Baseline (adaptation disabled)); colon: 96.1538% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.0392% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.0392% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.5926% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.5926% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.9091% (minimum 99%, Baseline (adaptation disabled)); liver: 92.5926% (minimum 99%, Baseline (adaptation disabled)); lung: 90.9091% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.0392% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.2069% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.1538% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.7193% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.1538% (minimum 97%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); skin: 90.9091% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.1538% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0392% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.9091% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.1538% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 90.9091% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.2,0.5,0.5,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000155530,LRGUK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0409091,-0.0609091,-0.380244
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.1538% (minimum 99%, Missing); amygdala: 96.1538% (minimum 99%, Missing); basal ganglia: 92.5926% (minimum 99%, Missing); bone marrow: 89.2857% (minimum 99%, Missing); cerebellum: 98.0392% (minimum 99%, Missing); cerebral cortex: 98.0392% (minimum 99%, Missing); choroid plexus: 60.9756% (minimum 99%, Missing); colon: 96.1538% (minimum 97%, Missing); duodenum: 98.0392% (minimum 99%, Missing); heart muscle: 98.0392% (minimum 99%, Missing); hippocampal formation: 92.5926% (minimum 99%, Missing); hypothalamus: 92.5926% (minimum 99%, Missing); kidney: 90.9091% (minimum 99%, Missing); liver: 92.5926% (minimum 99%, Missing); lung: 90.9091% (minimum 99%, Missing); midbrain: 98.0392% (minimum 99%, Missing); pancreas: 86.2069% (minimum 99%, Missing); parathyroid gland: 96.1538% (minimum 97%, Missing); pituitary gland: 87.7193% (minimum 99%, Missing); rectum: 96.1538% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 90.9091% (minimum 97%, Missing); skin: 90.9091% (minimum 95%, Missing); small intestine: 96.1538% (minimum 99%, Missing); smooth muscle: 96.1538% (minimum 99%, Missing); spinal cord: 98.0392% (minimum 99%, Missing); spleen: 90.9091% (minimum 95%, Missing); stomach: 96.1538% (minimum 97%, Missing); thyroid gland: 90.9091% (minimum 95%, Missing)",0,80,unavailable,3.2,0.5,0.5,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000155530,LRGUK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0409091,-0.0609091,-0.380244
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4,4.4,2.3,"tongue: 4.4 nTPM (protected, limit 2); retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000155592,ZKSCAN2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.4717% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.4286% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.7273% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.9655% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.9655% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.5161% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.1064% (minimum 99%, Baseline (adaptation disabled)); colon: 75.4717% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.9565% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.9565% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.9655% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.4286% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.7966% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.7273% (minimum 99%, Baseline (adaptation disabled)); liver: 71.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 78.4314% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.9231% (minimum 97%, Baseline (adaptation disabled)); midbrain: 72.7273% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.8235% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.4286% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.6327% (minimum 97%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.4314% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 56.3380% (minimum 99%, Baseline (adaptation disabled)); skin: 86.9565% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.6327% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.9655% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.4286% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.4314% (minimum 97%, Baseline (adaptation disabled)); thymus: 63.4921% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 47.6190% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.4314% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4,4.4,2.3,"tongue: 4.4 nTPM (protected, limit 2); retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000155592,ZKSCAN2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.315079,-0.49381,-0.49
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Missing); adrenal gland: 75.4717% (minimum 99%, Missing); amygdala: 71.4286% (minimum 99%, Missing); basal ganglia: 72.7273% (minimum 99%, Missing); bone marrow: 68.9655% (minimum 99%, Missing); cerebellum: 68.9655% (minimum 99%, Missing); cerebral cortex: 64.5161% (minimum 99%, Missing); choroid plexus: 85.1064% (minimum 99%, Missing); colon: 75.4717% (minimum 97%, Missing); duodenum: 86.9565% (minimum 99%, Missing); esophagus: 86.9565% (minimum 97%, Missing); heart muscle: 68.9655% (minimum 99%, Missing); hippocampal formation: 71.4286% (minimum 99%, Missing); hypothalamus: 67.7966% (minimum 99%, Missing); kidney: 72.7273% (minimum 99%, Missing); liver: 71.4286% (minimum 99%, Missing); lung: 78.4314% (minimum 99%, Missing); lymph node: 76.9231% (minimum 97%, Missing); midbrain: 72.7273% (minimum 99%, Missing); pancreas: 80.0000% (minimum 99%, Missing); parathyroid gland: 58.8235% (minimum 97%, Missing); pituitary gland: 71.4286% (minimum 99%, Missing); rectum: 81.6327% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 78.4314% (minimum 97%, Missing); skeletal muscle: 56.3380% (minimum 99%, Missing); skin: 86.9565% (minimum 95%, Missing); small intestine: 81.6327% (minimum 99%, Missing); smooth muscle: 68.9655% (minimum 99%, Missing); spinal cord: 71.4286% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 78.4314% (minimum 97%, Missing); thymus: 63.4921% (minimum 95%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); tongue: 47.6190% (minimum 97%, Missing); urinary bladder: 78.4314% (minimum 97%, Missing)",0,80,unavailable,4,4.4,2.3,"tongue: 4.4 nTPM (protected, limit 2); retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000155592,ZKSCAN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.315079,-0.49381,-0.49
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,11.2,9.6,10.7,"duodenum: 11.2 nTPM (vital, limit 1); skin: 10.7 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 2); urinary bladder: 9.3 nTPM (protected, limit 2); salivary gland: 8.5 nTPM (protected, limit 2); lymph node: 8.3 nTPM (protected, limit 4); skeletal muscle: 8.3 nTPM (vital, limit 1); thyroid gland: 8.2 nTPM (manageable, limit 5); thymus: 8.2 nTPM (manageable, limit 5); midbrain: 8 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 2); small intestine: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 2); hippocampal formation: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 2); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); adrenal gland: 6.4 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000155621,C9orf85,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.9888% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.1302% (minimum 99%, Baseline (adaptation disabled)); amygdala: 60.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 59.6591% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.4172% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.5396% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.0244% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.4681% (minimum 99%, Baseline (adaptation disabled)); colon: 58.6592% (minimum 97%, Baseline (adaptation disabled)); duodenum: 48.3871% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.2388% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.0244% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.9888% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.6936% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.0465% (minimum 99%, Baseline (adaptation disabled)); liver: 58.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 68.1818% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.8511% (minimum 97%, Baseline (adaptation disabled)); midbrain: 56.7568% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.0110% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.0789% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.4172% (minimum 99%, Baseline (adaptation disabled)); rectum: 59.3220% (minimum 97%, Baseline (adaptation disabled)); retina: 63.6364% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.2632% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.8511% (minimum 99%, Baseline (adaptation disabled)); skin: 49.5283% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.0652% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.6364% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.7246% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.4035% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.1497% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.1497% (minimum 95%, Baseline (adaptation disabled)); tongue: 57.0652% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.0303% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,11.2,9.6,10.7,"duodenum: 11.2 nTPM (vital, limit 1); skin: 10.7 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 2); urinary bladder: 9.3 nTPM (protected, limit 2); salivary gland: 8.5 nTPM (protected, limit 2); skeletal muscle: 8.3 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 2); thyroid gland: 8.2 nTPM (manageable, limit 5); thymus: 8.2 nTPM (manageable, limit 5); midbrain: 8 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 2); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 2); adipose tissue: 7.3 nTPM (manageable, limit 5); hippocampal formation: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 2); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); adrenal gland: 6.4 nTPM (vital, limit 1); spleen: 6.3 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000155621,C9orf85,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.454717,-0.447612,-0.506129
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.9888% (minimum 90%, Approved); adrenal gland: 62.1302% (minimum 99%, Missing); amygdala: 60.0000% (minimum 99%, Missing); basal ganglia: 59.6591% (minimum 99%, Missing); bone marrow: 64.4172% (minimum 98%, Approved); cerebellum: 75.5396% (minimum 99%, Missing); cerebral cortex: 64.0244% (minimum 99%, Missing); choroid plexus: 74.4681% (minimum 99%, Missing); colon: 58.6592% (minimum 97%, Missing); duodenum: 48.3871% (minimum 99%, Missing); esophagus: 52.2388% (minimum 97%, Missing); heart muscle: 64.0244% (minimum 99%, Missing); hippocampal formation: 58.9888% (minimum 99%, Missing); hypothalamus: 60.6936% (minimum 99%, Missing); kidney: 61.0465% (minimum 99%, Missing); liver: 58.3333% (minimum 99%, Missing); lung: 68.1818% (minimum 99%, Missing); lymph node: 55.8511% (minimum 95%, Approved); midbrain: 56.7568% (minimum 99%, Missing); pancreas: 58.0110% (minimum 99%, Missing); parathyroid gland: 69.0789% (minimum 97%, Missing); pituitary gland: 64.4172% (minimum 99%, Missing); rectum: 59.3220% (minimum 97%, Missing); retina: 63.6364% (minimum 99%, Missing); salivary gland: 55.2632% (minimum 97%, Missing); skeletal muscle: 55.8511% (minimum 99%, Missing); skin: 49.5283% (minimum 95%, Missing); small intestine: 57.0652% (minimum 99%, Missing); smooth muscle: 63.6364% (minimum 98%, Approved); spinal cord: 50.7246% (minimum 99%, Missing); spleen: 62.5000% (minimum 90%, Approved); stomach: 61.4035% (minimum 97%, Missing); thymus: 56.1497% (minimum 95%, Missing); thyroid gland: 56.1497% (minimum 95%, Missing); tongue: 57.0652% (minimum 97%, Missing); urinary bladder: 53.0303% (minimum 97%, Missing)",0,7,partial,11.2,9.6,10.7,"duodenum: 11.2 nTPM (vital, limit 1); skin: 10.7 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 2); urinary bladder: 9.3 nTPM (protected, limit 2); salivary gland: 8.5 nTPM (protected, limit 2); lymph node: 8.3 nTPM (protected, limit 4); skeletal muscle: 8.3 nTPM (vital, limit 1); thyroid gland: 8.2 nTPM (manageable, limit 5); thymus: 8.2 nTPM (manageable, limit 5); midbrain: 8 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 2); small intestine: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 2); hippocampal formation: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 2); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); adrenal gland: 6.4 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000155621,C9orf85,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.454717,-0.447612,-0.506129
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,False,,0,3,unreliable,5.5,0.1,0.2,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),50,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000155622,XAGE2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"lung: 97.2222% (minimum 99%, Baseline (adaptation disabled))",0,3,unreliable,5.5,0.1,0.2,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),50,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000155622,XAGE2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0489621,0.0294808,-0.0177778
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"lung: 97.2222% (minimum 99%, Missing)",0,3,unreliable,5.5,0.1,0.2,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),50,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000155622,XAGE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0489621,0.0294808,-0.0177778
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2,0.2,0.1,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000155714,PDZD9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.5752% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.5254% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.3750% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.3077% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.7368% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.7368% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.4286% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.2973% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.1818% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.1818% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2,0.2,0.1,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000155714,PDZD9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0408257,0.0118182,-0.14625
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.5752% (minimum 99%, Missing); basal ganglia: 91.5254% (minimum 99%, Missing); cerebellum: 84.3750% (minimum 99%, Missing); cerebral cortex: 92.3077% (minimum 99%, Missing); hippocampal formation: 94.7368% (minimum 99%, Missing); hypothalamus: 94.7368% (minimum 99%, Missing); midbrain: 96.4286% (minimum 99%, Missing); pituitary gland: 97.2973% (minimum 99%, Missing); small intestine: 98.1818% (minimum 99%, Missing); spinal cord: 98.1818% (minimum 99%, Missing)",0,80,unavailable,2,0.2,0.1,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000155714,PDZD9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0408257,0.0118182,-0.14625
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,1,partial,0.4,0.2,2,,spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000155719,OTOA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.1220% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.8571% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.8571% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 92.8571% (minimum 99%, Baseline (adaptation disabled)); lung: 95.1220% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.1220% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.6977% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.1017% (minimum 95%, Baseline (adaptation disabled)); thymus: 92.8571% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,0.4,0.2,2,,spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000155719,OTOA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.288983,-0.0187805,-0.0830233
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.5000% (minimum 99%, Missing); basal ganglia: 97.5000% (minimum 99%, Missing); bone marrow: 92.8571% (minimum 95%, Enhanced); cerebral cortex: 92.8571% (minimum 95%, Enhanced); hippocampal formation: 97.5000% (minimum 99%, Missing); liver: 92.8571% (minimum 95%, Enhanced); pituitary gland: 92.8571% (minimum 99%, Missing); spinal cord: 90.6977% (minimum 99%, Missing); spleen: 66.1017% (minimum 95%, Missing); thymus: 92.8571% (minimum 95%, Missing)",0,1,partial,0.4,0.2,2,,spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000155719,OTOA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.288983,0.03,-0.0830233
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.7,1.4,1.6,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000155749,FLACC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.8571% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.3182% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.7853% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.2473% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.8519% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.5116% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.3182% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.6126% (minimum 99%, Baseline (adaptation disabled)); colon: 95.4023% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.0760% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.7853% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.1932% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.7104% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.7297% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.2584% (minimum 99%, Baseline (adaptation disabled)); liver: 95.9538% (minimum 99%, Baseline (adaptation disabled)); lung: 87.3684% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.2222% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.8571% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.8571% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.9538% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.7853% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.8571% (minimum 97%, Baseline (adaptation disabled)); retina: 83.8384% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.7853% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.7104% (minimum 99%, Baseline (adaptation disabled)); skin: 93.7853% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.3182% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.5116% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.4023% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 91.2088% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.5116% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.7,1.4,1.6,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000155749,FLACC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0379121,-0.0477778,-0.333874
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.8571% (minimum 95%, Missing); adrenal gland: 94.3182% (minimum 99%, Missing); amygdala: 93.7853% (minimum 99%, Missing); basal ganglia: 89.2473% (minimum 99%, Missing); bone marrow: 76.8519% (minimum 99%, Missing); cerebellum: 96.5116% (minimum 99%, Missing); cerebral cortex: 94.3182% (minimum 99%, Missing); choroid plexus: 65.6126% (minimum 99%, Missing); colon: 95.4023% (minimum 97%, Missing); duodenum: 97.0760% (minimum 99%, Missing); esophagus: 93.7853% (minimum 97%, Missing); heart muscle: 80.1932% (minimum 99%, Missing); hippocampal formation: 90.7104% (minimum 99%, Missing); hypothalamus: 89.7297% (minimum 99%, Missing); kidney: 93.2584% (minimum 99%, Missing); liver: 95.9538% (minimum 99%, Missing); lung: 87.3684% (minimum 99%, Missing); lymph node: 92.2222% (minimum 97%, Missing); midbrain: 94.8571% (minimum 99%, Missing); pancreas: 94.8571% (minimum 99%, Missing); parathyroid gland: 95.9538% (minimum 97%, Missing); pituitary gland: 93.7853% (minimum 99%, Missing); rectum: 94.8571% (minimum 97%, Missing); retina: 83.8384% (minimum 99%, Missing); salivary gland: 93.7853% (minimum 97%, Missing); skeletal muscle: 90.7104% (minimum 99%, Missing); skin: 93.7853% (minimum 95%, Missing); small intestine: 94.3182% (minimum 99%, Missing); smooth muscle: 96.5116% (minimum 99%, Missing); spinal cord: 95.4023% (minimum 99%, Missing); thyroid gland: 91.2088% (minimum 95%, Missing); urinary bladder: 96.5116% (minimum 97%, Missing)",0,80,unavailable,8.7,1.4,1.6,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000155749,FLACC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0379121,-0.0477778,-0.333874
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.2,0.2,0.6,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,ENSG00000155754,C2CD6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2234% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.9925% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.9925% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.9770% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.2234% (minimum 99%, Baseline (adaptation disabled)); retina: 97.7273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.2362% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.2,0.2,0.6,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,ENSG00000155754,C2CD6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,0.0347328,0.0248586,-0.0200752
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2234% (minimum 99%, Missing); choroid plexus: 96.9925% (minimum 99%, Missing); heart muscle: 96.9925% (minimum 99%, Missing); midbrain: 98.9770% (minimum 99%, Missing); pituitary gland: 98.2234% (minimum 99%, Missing); retina: 97.7273% (minimum 99%, Missing); spinal cord: 97.2362% (minimum 99%, Missing)",0,80,unavailable,1.2,0.2,0.6,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,ENSG00000155754,C2CD6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,0.0347328,0.0248586,-0.0200752
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000155833,CYLC2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000155833,CYLC2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000155833,CYLC2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,2,partial,0.2,0.1,0.2,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,ENSG00000155875,SAXO1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,0.2,0.1,0.2,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,ENSG00000155875,SAXO1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0446809,0.0273333,0.00468085
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,0.2,0.1,0.2,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,ENSG00000155875,SAXO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0473333,0.03,0.00468085
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000155890,TRIM42,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000155890,TRIM42,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000155890,TRIM42,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,3,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000156009,MAGEA8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.4615% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000156009,MAGEA8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0422481,0.03,-0.00538462
True,compatible,,True,True,True,,0,3,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000156009,MAGEA8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.00224806
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,58.6,4.1,6.1,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000156042,CFAP70,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.1748% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.8565% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.8565% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.9796% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.1748% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.9431% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 24.8718% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.5174% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.1748% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.2618% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.1653% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.8519% (minimum 99%, Baseline (adaptation disabled)); liver: 89.8148% (minimum 99%, Baseline (adaptation disabled)); lung: 86.9955% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.5174% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.5094% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.3874% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.5532% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.6923% (minimum 99%, Baseline (adaptation disabled)); retina: 65.9864% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.8148% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.5174% (minimum 99%, Baseline (adaptation disabled)); skin: 88.1818% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.5174% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.9798% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.5094% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.7198% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.1748% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 76.0784% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.5665% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,58.6,4.1,6.1,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); hypothalamus: 4.8 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 2); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); liver: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000156042,CFAP70,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.189216,-0.144468,-0.741282
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 81.8565% (minimum 99%, Missing); amygdala: 86.2222% (minimum 99%, Missing); basal ganglia: 81.8565% (minimum 99%, Missing); cerebellum: 94.1748% (minimum 95%, Enhanced); cerebral cortex: 91.9431% (minimum 95%, Enhanced); choroid plexus: 24.8718% (minimum 99%, Missing); heart muscle: 94.1748% (minimum 95%, Enhanced); hippocampal formation: 83.2618% (minimum 99%, Missing); hypothalamus: 80.1653% (minimum 99%, Missing); kidney: 71.8519% (minimum 95%, Enhanced); liver: 89.8148% (minimum 95%, Enhanced); lung: 86.9955% (minimum 99%, Missing); midbrain: 91.5094% (minimum 99%, Missing); pancreas: 87.3874% (minimum 95%, Enhanced); pituitary gland: 59.6923% (minimum 99%, Missing); retina: 65.9864% (minimum 99%, Missing); spinal cord: 91.5094% (minimum 99%, Missing)",0,6,partial,58.6,4.1,6.1,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000156042,CFAP70,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.02,0,-0.741282
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,4.9,3.3,2.4,"retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156172,CFAP418,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.0909% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.0909% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.4615% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.6087% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.8571% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.2903% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 59.3750% (minimum 99%, Baseline (adaptation disabled)); colon: 79.1667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.8511% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.1667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.3750% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.4068% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.2951% (minimum 99%, Baseline (adaptation disabled)); liver: 69.0909% (minimum 99%, Baseline (adaptation disabled)); lung: 71.6981% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.4068% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.4068% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 53.5211% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.8511% (minimum 97%, Baseline (adaptation disabled)); retina: 43.6782% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.6981% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 79.1667% (minimum 99%, Baseline (adaptation disabled)); skin: 71.6981% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.1667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.8571% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.3704% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.5510% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.2951% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.2903% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.8571% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.5510% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,4.9,3.3,2.4,"retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156172,CFAP418,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.337097,-0.434789,-0.553218
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.0909% (minimum 95%, Missing); adrenal gland: 69.0909% (minimum 99%, Missing); amygdala: 63.3333% (minimum 99%, Missing); basal ganglia: 58.4615% (minimum 99%, Missing); bone marrow: 82.6087% (minimum 99%, Missing); cerebellum: 67.8571% (minimum 98%, Approved); cerebral cortex: 61.2903% (minimum 99%, Missing); choroid plexus: 59.3750% (minimum 99%, Missing); colon: 79.1667% (minimum 97%, Missing); duodenum: 80.8511% (minimum 99%, Missing); esophagus: 79.1667% (minimum 97%, Missing); heart muscle: 59.3750% (minimum 99%, Missing); hippocampal formation: 64.4068% (minimum 99%, Missing); hypothalamus: 63.3333% (minimum 99%, Missing); kidney: 62.2951% (minimum 99%, Missing); liver: 69.0909% (minimum 99%, Missing); lung: 71.6981% (minimum 99%, Missing); lymph node: 64.4068% (minimum 97%, Missing); midbrain: 64.4068% (minimum 99%, Missing); pancreas: 76.0000% (minimum 99%, Missing); parathyroid gland: 53.5211% (minimum 97%, Missing); pituitary gland: 63.3333% (minimum 99%, Missing); rectum: 80.8511% (minimum 97%, Missing); retina: 43.6782% (minimum 99%, Missing); salivary gland: 71.6981% (minimum 95%, Approved); skeletal muscle: 79.1667% (minimum 99%, Missing); skin: 71.6981% (minimum 90%, Approved); small intestine: 79.1667% (minimum 99%, Missing); smooth muscle: 63.3333% (minimum 98%, Approved); spinal cord: 67.8571% (minimum 99%, Missing); spleen: 70.3704% (minimum 95%, Missing); stomach: 77.5510% (minimum 97%, Missing); thymus: 62.2951% (minimum 95%, Missing); thyroid gland: 61.2903% (minimum 95%, Missing); tongue: 67.8571% (minimum 97%, Missing); urinary bladder: 77.5510% (minimum 97%, Missing)",0,0,routine_complete,4.9,3.3,2.4,"retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156172,CFAP418,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.337097,-0.434789,-0.553218
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,231.4,0,0.1,"retina: 231.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000156194,PPEF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"basal ganglia: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 45.4545% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 38.4615% (minimum 99%, Baseline (adaptation disabled)); retina: 0.2156% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3333% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,231.4,0,0.1,"retina: 231.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000156194,PPEF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.116667,0.03,-0.987844
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"basal ganglia: 83.3333% (minimum 99%, Missing); cerebellum: 45.4545% (minimum 99%, Missing); choroid plexus: 38.4615% (minimum 99%, Missing); retina: 0.2156% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing)",0,80,unavailable,231.4,0,0.1,"retina: 231.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000156194,PPEF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.116667,0.03,-0.987844
True,compatible,,True,True,False,,0,2,partial,0.4,0,0.1,,,53,not_established,not_triggered,,,ENSG00000156269,NAA11,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.3607% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.3607% (minimum 99%, Baseline (adaptation disabled)); retina: 93.7500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.3607% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.4,0,0.1,,,53,not_established,not_triggered,,,ENSG00000156269,NAA11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;Loriot 2025;da Silva 2017,0.0336066,0.03,-0.0525
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.3607% (minimum 99%, Missing); retina: 93.7500% (minimum 99%, Missing)",0,2,partial,0.4,0,0.1,,,53,not_established,not_triggered,,,ENSG00000156269,NAA11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,-0.0525
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,8,partial,88.2,28.6,22.6,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 2); urinary bladder: 28.6 nTPM (protected, limit 2); skeletal muscle: 25.4 nTPM (vital, limit 2); skin: 22.6 nTPM (manageable, limit 5); esophagus: 22.2 nTPM (protected, limit 2); lung: 20.7 nTPM (vital, limit 2); spleen: 20.1 nTPM (manageable, limit 10); small intestine: 16.9 nTPM (vital, limit 1); salivary gland: 16.9 nTPM (protected, limit 4); pancreas: 16.7 nTPM (vital, limit 2); lymph node: 16.4 nTPM (protected, limit 4); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); adipose tissue: 15.3 nTPM (manageable, limit 10); kidney: 15.3 nTPM (vital, limit 2); thymus: 13.8 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 2); colon: 12.9 nTPM (protected, limit 2); heart muscle: 12.7 nTPM (vital, limit 1); rectum: 12.7 nTPM (protected, limit 4); tongue: 12.3 nTPM (protected, limit 2); thyroid gland: 12.2 nTPM (manageable, limit 10); adrenal gland: 11.7 nTPM (vital, limit 2); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 2); parathyroid gland: 8.1 nTPM (protected, limit 4); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156273,BACH1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.1682% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.6931% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.0904% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.1429% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 35.6674% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.5078% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.4560% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.5730% (minimum 99%, Baseline (adaptation disabled)); colon: 79.1262% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.7764% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.3831% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.2642% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.6136% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.1682% (minimum 99%, Baseline (adaptation disabled)); liver: 62.2930% (minimum 99%, Baseline (adaptation disabled)); lung: 70.2586% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.8851% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.7236% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.5427% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.7895% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.6782% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.3831% (minimum 97%, Baseline (adaptation disabled)); retina: 80.9603% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.3161% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.8143% (minimum 99%, Baseline (adaptation disabled)); skin: 68.3916% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.3161% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.0498% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.7248% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.8696% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.8710% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.9904% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 80.0327% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.9020% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.0968% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,88.2,28.6,22.6,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 1); urinary bladder: 28.6 nTPM (protected, limit 2); skeletal muscle: 25.4 nTPM (vital, limit 1); skin: 22.6 nTPM (manageable, limit 5); esophagus: 22.2 nTPM (protected, limit 2); lung: 20.7 nTPM (vital, limit 1); spleen: 20.1 nTPM (manageable, limit 5); small intestine: 16.9 nTPM (vital, limit 1); salivary gland: 16.9 nTPM (protected, limit 2); pancreas: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 2); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); adipose tissue: 15.3 nTPM (manageable, limit 5); kidney: 15.3 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 2); colon: 12.9 nTPM (protected, limit 2); heart muscle: 12.7 nTPM (vital, limit 1); rectum: 12.7 nTPM (protected, limit 2); tongue: 12.3 nTPM (protected, limit 2); thyroid gland: 12.2 nTPM (manageable, limit 5); adrenal gland: 11.7 nTPM (vital, limit 1); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 2); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156273,BACH1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.266084,-0.339032,-0.633326
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.1682% (minimum 90%, Approved); adrenal gland: 80.6931% (minimum 98%, Approved); amygdala: 92.0904% (minimum 99%, Missing); basal ganglia: 93.1429% (minimum 99%, Missing); bone marrow: 35.6674% (minimum 99%, Missing); cerebellum: 95.5078% (minimum 98%, Approved); cerebral cortex: 84.4560% (minimum 98%, Approved); choroid plexus: 91.5730% (minimum 99%, Missing); colon: 79.1262% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 68.7764% (minimum 97%, Missing); heart muscle: 79.3831% (minimum 99%, Missing); hippocampal formation: 92.2642% (minimum 99%, Missing); hypothalamus: 92.6136% (minimum 99%, Missing); kidney: 76.1682% (minimum 98%, Approved); liver: 62.2930% (minimum 98%, Approved); lung: 70.2586% (minimum 98%, Approved); lymph node: 74.8851% (minimum 95%, Approved); midbrain: 90.7236% (minimum 99%, Missing); pancreas: 74.5427% (minimum 98%, Approved); parathyroid gland: 85.7895% (minimum 95%, Approved); pituitary gland: 93.6782% (minimum 99%, Missing); rectum: 79.3831% (minimum 95%, Approved); retina: 80.9603% (minimum 99%, Missing); salivary gland: 74.3161% (minimum 95%, Approved); skeletal muscle: 65.8143% (minimum 98%, Approved); skin: 68.3916% (minimum 95%, Missing); small intestine: 74.3161% (minimum 99%, Missing); smooth muscle: 76.0498% (minimum 99%, Missing); spinal cord: 89.7248% (minimum 99%, Missing); spleen: 70.8696% (minimum 90%, Approved); stomach: 78.8710% (minimum 97%, Missing); thymus: 77.9904% (minimum 95%, Missing); thyroid gland: 80.0327% (minimum 90%, Approved); tongue: 79.9020% (minimum 97%, Missing); urinary bladder: 63.0968% (minimum 97%, Missing)",0,8,partial,88.2,28.6,22.6,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 2); urinary bladder: 28.6 nTPM (protected, limit 2); skeletal muscle: 25.4 nTPM (vital, limit 2); skin: 22.6 nTPM (manageable, limit 5); esophagus: 22.2 nTPM (protected, limit 2); lung: 20.7 nTPM (vital, limit 2); spleen: 20.1 nTPM (manageable, limit 10); small intestine: 16.9 nTPM (vital, limit 1); salivary gland: 16.9 nTPM (protected, limit 4); pancreas: 16.7 nTPM (vital, limit 2); lymph node: 16.4 nTPM (protected, limit 4); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); adipose tissue: 15.3 nTPM (manageable, limit 10); kidney: 15.3 nTPM (vital, limit 2); thymus: 13.8 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 2); colon: 12.9 nTPM (protected, limit 2); heart muscle: 12.7 nTPM (vital, limit 1); rectum: 12.7 nTPM (protected, limit 4); tongue: 12.3 nTPM (protected, limit 2); thyroid gland: 12.2 nTPM (manageable, limit 10); adrenal gland: 11.7 nTPM (vital, limit 2); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 2); parathyroid gland: 8.1 nTPM (protected, limit 4); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156273,BACH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.266084,-0.339032,-0.633326
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,32,8.8,18.6,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (manageable, limit 10); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 2); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 2); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 2); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); kidney: 6 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); salivary gland: 5.1 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); lymph node: 3.6 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156313,RPGR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.5517% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.3119% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.9362% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.5970% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 57.2438% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.3226% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.6441% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 51.2658% (minimum 99%, Baseline (adaptation disabled)); colon: 64.8000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.8168% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.3488% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.0350% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.0316% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.0645% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.9730% (minimum 99%, Baseline (adaptation disabled)); liver: 81.8182% (minimum 99%, Baseline (adaptation disabled)); lung: 52.9412% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.8182% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.5483% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.2308% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.6310% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 33.6100% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.2335% (minimum 97%, Baseline (adaptation disabled)); retina: 57.8571% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.0563% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.2734% (minimum 99%, Baseline (adaptation disabled)); skin: 73.6364% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.0316% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 79.0244% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.7786% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.4151% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.0526% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.8846% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 63.2812% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.8182% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.8537% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,32,8.8,18.6,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (manageable, limit 5); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 1); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 2); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 2); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); kidney: 6 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); salivary gland: 5.1 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); lymph node: 3.6 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156313,RPGR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.484483,-0.322,-0.6539
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.5517% (minimum 90%, Approved); adrenal gland: 74.3119% (minimum 99%, Missing); amygdala: 68.9362% (minimum 99%, Missing); basal ganglia: 61.5970% (minimum 99%, Missing); bone marrow: 57.2438% (minimum 98%, Approved); cerebellum: 65.3226% (minimum 99%, Missing); cerebral cortex: 68.6441% (minimum 99%, Missing); choroid plexus: 51.2658% (minimum 99%, Missing); colon: 64.8000% (minimum 97%, Missing); duodenum: 84.8168% (minimum 99%, Missing); esophagus: 75.3488% (minimum 97%, Missing); heart muscle: 63.0350% (minimum 99%, Missing); hippocampal formation: 64.0316% (minimum 99%, Missing); hypothalamus: 58.0645% (minimum 99%, Missing); kidney: 72.9730% (minimum 99%, Missing); liver: 81.8182% (minimum 99%, Missing); lung: 52.9412% (minimum 99%, Missing); lymph node: 81.8182% (minimum 97%, Missing); midbrain: 62.5483% (minimum 99%, Missing); pancreas: 69.2308% (minimum 99%, Missing); parathyroid gland: 86.6310% (minimum 97%, Missing); pituitary gland: 33.6100% (minimum 99%, Missing); rectum: 82.2335% (minimum 97%, Missing); retina: 57.8571% (minimum 99%, Missing); salivary gland: 76.0563% (minimum 97%, Missing); skeletal muscle: 58.2734% (minimum 99%, Missing); skin: 73.6364% (minimum 95%, Missing); small intestine: 64.0316% (minimum 99%, Missing); smooth muscle: 79.0244% (minimum 99%, Missing); spinal cord: 59.7786% (minimum 99%, Missing); spleen: 76.4151% (minimum 90%, Approved); stomach: 71.0526% (minimum 97%, Missing); thymus: 77.8846% (minimum 95%, Missing); thyroid gland: 63.2812% (minimum 95%, Missing); tongue: 81.8182% (minimum 97%, Missing); urinary bladder: 65.8537% (minimum 97%, Missing)",0,4,partial,32,8.8,18.6,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (manageable, limit 10); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 2); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 2); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 2); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); kidney: 6 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); salivary gland: 5.1 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 2); lymph node: 3.6 nTPM (protected, limit 2); rectum: 3.5 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2)",adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156313,RPGR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.434483,-0.322,-0.6539
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.2,8.8,11.3,"thymus: 11.3 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); small intestine: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); urinary bladder: 5.2 nTPM (protected, limit 2); basal ganglia: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); parathyroid gland: 3.4 nTPM (protected, limit 2); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000156384,SFR1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.4643% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.5430% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.0702% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.3913% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.4928% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.9623% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.9508% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.5312% (minimum 99%, Baseline (adaptation disabled)); colon: 77.7293% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.8206% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.1111% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.9163% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.7447% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.8206% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.1111% (minimum 99%, Baseline (adaptation disabled)); liver: 85.5769% (minimum 99%, Baseline (adaptation disabled)); lung: 74.4770% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.9173% (minimum 97%, Baseline (adaptation disabled)); midbrain: 72.6531% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.7447% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.9623% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.4078% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.1667% (minimum 97%, Baseline (adaptation disabled)); retina: 80.9091% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.0276% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.6514% (minimum 99%, Baseline (adaptation disabled)); skin: 80.5430% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.1055% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.7241% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.5714% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.4770% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.0563% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.1684% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.4859% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.0702% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.3913% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.2,8.8,11.3,"thymus: 11.3 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); small intestine: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); urinary bladder: 5.2 nTPM (protected, limit 2); basal ganglia: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); parathyroid gland: 3.4 nTPM (protected, limit 2); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000156384,SFR1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.338316,-0.300827,-0.354286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.4643% (minimum 95%, Missing); adrenal gland: 80.5430% (minimum 99%, Missing); amygdala: 78.0702% (minimum 99%, Missing); basal ganglia: 77.3913% (minimum 99%, Missing); bone marrow: 64.4928% (minimum 99%, Missing); cerebellum: 83.9623% (minimum 99%, Missing); cerebral cortex: 72.9508% (minimum 99%, Missing); choroid plexus: 69.5312% (minimum 99%, Missing); colon: 77.7293% (minimum 97%, Missing); duodenum: 79.8206% (minimum 99%, Missing); esophagus: 79.1111% (minimum 97%, Missing); heart muscle: 70.9163% (minimum 99%, Missing); hippocampal formation: 75.7447% (minimum 99%, Missing); hypothalamus: 79.8206% (minimum 99%, Missing); kidney: 79.1111% (minimum 99%, Missing); liver: 85.5769% (minimum 99%, Missing); lung: 74.4770% (minimum 99%, Missing); lymph node: 66.9173% (minimum 97%, Missing); midbrain: 72.6531% (minimum 99%, Missing); pancreas: 75.7447% (minimum 99%, Missing); parathyroid gland: 83.9623% (minimum 97%, Missing); pituitary gland: 86.4078% (minimum 99%, Missing); rectum: 74.1667% (minimum 97%, Missing); retina: 80.9091% (minimum 99%, Missing); salivary gland: 82.0276% (minimum 97%, Missing); skeletal muscle: 81.6514% (minimum 99%, Missing); skin: 80.5430% (minimum 95%, Missing); small intestine: 75.1055% (minimum 99%, Missing); smooth muscle: 76.7241% (minimum 99%, Missing); spinal cord: 63.5714% (minimum 99%, Missing); spleen: 74.4770% (minimum 95%, Missing); stomach: 77.0563% (minimum 97%, Missing); thymus: 61.1684% (minimum 95%, Missing); thyroid gland: 71.4859% (minimum 95%, Missing); tongue: 78.0702% (minimum 97%, Missing); urinary bladder: 77.3913% (minimum 97%, Missing)",0,80,unavailable,10.2,8.8,11.3,"thymus: 11.3 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 2); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); small intestine: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 2); urinary bladder: 5.2 nTPM (protected, limit 2); basal ganglia: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); parathyroid gland: 3.4 nTPM (protected, limit 2); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000156384,SFR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.338316,-0.300827,-0.354286
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.7,0.8,1.3,"heart muscle: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus,ENSG00000156466,GDF6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.9831% (minimum 95%, Baseline (adaptation disabled)); amygdala: 93.7500% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.1308% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.4545% (minimum 99%, Baseline (adaptation disabled)); colon: 93.7500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.2222% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.3303% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.5455% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.3303% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.4545% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.1308% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2222% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1308% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.3303% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.5946% (minimum 99%, Baseline (adaptation disabled)); small intestine: 92.9204% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.3043% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.5946% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 94.5946% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.9204% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.7,0.8,1.3,"heart muscle: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus,ENSG00000156466,GDF6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0601695,-0.0407965,-0.194545
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.9831% (minimum 95%, Missing); amygdala: 93.7500% (minimum 99%, Missing); basal ganglia: 98.1308% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); colon: 93.7500% (minimum 97%, Missing); duodenum: 97.2222% (minimum 99%, Missing); esophagus: 96.3303% (minimum 97%, Missing); heart muscle: 79.5455% (minimum 99%, Missing); hippocampal formation: 96.3303% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); kidney: 98.1308% (minimum 99%, Missing); liver: 97.2222% (minimum 99%, Missing); lung: 98.1308% (minimum 99%, Missing); midbrain: 96.3303% (minimum 99%, Missing); pancreas: 94.5946% (minimum 99%, Missing); small intestine: 92.9204% (minimum 99%, Missing); smooth muscle: 91.3043% (minimum 99%, Missing); stomach: 94.5946% (minimum 97%, Missing); thyroid gland: 94.5946% (minimum 95%, Missing); urinary bladder: 92.9204% (minimum 97%, Missing)",0,80,unavailable,2.7,0.8,1.3,"heart muscle: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus,ENSG00000156466,GDF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0601695,-0.0407965,-0.194545
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,7.1,4.1,4.1,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); salivary gland: 4 nTPM (protected, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); stomach: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156500,PABIR3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.4000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.8333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.3509% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.1240% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.5802% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.2617% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.4000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 59.1954% (minimum 99%, Baseline (adaptation disabled)); colon: 85.8333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.9643% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.8333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.7931% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.1504% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.3509% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.2881% (minimum 99%, Baseline (adaptation disabled)); liver: 85.1240% (minimum 99%, Baseline (adaptation disabled)); lung: 83.0645% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.5278% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.1504% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.6364% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.2881% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.2881% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.2881% (minimum 97%, Baseline (adaptation disabled)); retina: 65.1899% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.0280% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.5546% (minimum 99%, Baseline (adaptation disabled)); skin: 88.0342% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.7931% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.0303% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.1504% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.5352% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.2308% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.5278% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.2881% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.7931% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.4262% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,7.1,4.1,4.1,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); salivary gland: 4 nTPM (protected, limit 2); smooth muscle: 2.9 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156500,PABIR3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.234722,-0.254722,-0.398046
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.4000% (minimum 90%, Approved); adrenal gland: 85.8333% (minimum 99%, Missing); amygdala: 90.3509% (minimum 99%, Missing); basal ganglia: 85.1240% (minimum 99%, Missing); bone marrow: 63.5802% (minimum 99%, Missing); cerebellum: 96.2617% (minimum 99%, Missing); cerebral cortex: 82.4000% (minimum 98%, Approved); choroid plexus: 59.1954% (minimum 99%, Missing); colon: 85.8333% (minimum 97%, Missing); duodenum: 91.9643% (minimum 99%, Missing); esophagus: 85.8333% (minimum 97%, Missing); heart muscle: 88.7931% (minimum 99%, Missing); hippocampal formation: 91.1504% (minimum 99%, Missing); hypothalamus: 90.3509% (minimum 99%, Missing); kidney: 87.2881% (minimum 99%, Missing); liver: 85.1240% (minimum 99%, Missing); lung: 83.0645% (minimum 99%, Missing); lymph node: 71.5278% (minimum 97%, Missing); midbrain: 91.1504% (minimum 99%, Missing); pancreas: 93.6364% (minimum 99%, Missing); parathyroid gland: 87.2881% (minimum 97%, Missing); pituitary gland: 87.2881% (minimum 99%, Missing); rectum: 87.2881% (minimum 97%, Missing); retina: 65.1899% (minimum 99%, Missing); salivary gland: 72.0280% (minimum 97%, Missing); skeletal muscle: 86.5546% (minimum 98%, Approved); skin: 88.0342% (minimum 95%, Missing); small intestine: 88.7931% (minimum 99%, Missing); smooth muscle: 78.0303% (minimum 98%, Approved); spinal cord: 91.1504% (minimum 99%, Missing); spleen: 72.5352% (minimum 95%, Missing); stomach: 79.2308% (minimum 97%, Missing); thymus: 71.5278% (minimum 95%, Missing); thyroid gland: 87.2881% (minimum 95%, Missing); tongue: 88.7931% (minimum 97%, Missing); urinary bladder: 84.4262% (minimum 97%, Missing)",0,4,partial,7.1,4.1,4.1,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); salivary gland: 4 nTPM (protected, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); stomach: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000156500,PABIR3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.234722,-0.254722,-0.398046
True,compatible,,True,True,False,,0,80,unavailable,0,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000156509,FBXO43,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 94.5946% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.1053% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000156509,FBXO43,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0289474,-0.0240541,0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 94.5946% (minimum 97%, Missing); thymus: 92.1053% (minimum 95%, Missing)",0,80,unavailable,0,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000156509,FBXO43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0289474,-0.0240541,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,5.9,4.1,4.2,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000156876,SASS6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.4156% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.4194% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.4211% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.5263% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.0149% (minimum 99%, Baseline (adaptation disabled)); colon: 75.5814% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.6522% (minimum 99%, Baseline (adaptation disabled)); esophagus: 76.4706% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.4156% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 82.2785% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.3208% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.4156% (minimum 99%, Baseline (adaptation disabled)); pancreas: 83.3333% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.1068% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.2469% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.1489% (minimum 97%, Baseline (adaptation disabled)); retina: 54.1667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.2683% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 75.5814% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.7126% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 79.2683% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.3810% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.4706% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.4706% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.7477% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.2500% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.8378% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.2785% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,5.9,4.1,4.2,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000156876,SASS6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.342523,-0.356792,-0.465806
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Missing); adrenal gland: 84.4156% (minimum 99%, Uncertain); amygdala: 86.6667% (minimum 99%, Missing); basal ganglia: 86.6667% (minimum 99%, Missing); bone marrow: 52.4194% (minimum 99%, Missing); cerebellum: 68.4211% (minimum 99%, Uncertain); cerebral cortex: 85.5263% (minimum 99%, Missing); choroid plexus: 97.0149% (minimum 99%, Missing); colon: 75.5814% (minimum 97%, Missing); duodenum: 70.6522% (minimum 99%, Missing); esophagus: 76.4706% (minimum 97%, Missing); heart muscle: 86.6667% (minimum 99%, Uncertain); hippocampal formation: 84.4156% (minimum 99%, Missing); hypothalamus: 86.6667% (minimum 99%, Missing); kidney: 86.6667% (minimum 99%, Missing); liver: 82.2785% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Uncertain); lymph node: 61.3208% (minimum 97%, Uncertain); midbrain: 84.4156% (minimum 99%, Missing); pancreas: 83.3333% (minimum 99%, Missing); parathyroid gland: 63.1068% (minimum 97%, Uncertain); pituitary gland: 80.2469% (minimum 99%, Missing); rectum: 69.1489% (minimum 97%, Missing); retina: 54.1667% (minimum 99%, Missing); salivary gland: 79.2683% (minimum 97%, Uncertain); skeletal muscle: 83.3333% (minimum 99%, Missing); skin: 75.5814% (minimum 95%, Missing); small intestine: 74.7126% (minimum 99%, Uncertain); smooth muscle: 79.2683% (minimum 99%, Missing); spinal cord: 77.3810% (minimum 99%, Missing); spleen: 76.4706% (minimum 95%, Uncertain); stomach: 76.4706% (minimum 97%, Missing); thymus: 60.7477% (minimum 95%, Missing); thyroid gland: 81.2500% (minimum 95%, Missing); tongue: 87.8378% (minimum 97%, Missing); urinary bladder: 82.2785% (minimum 97%, Missing)",0,4,partial,5.9,4.1,4.2,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 2); parathyroid gland: 3.8 nTPM (protected, limit 2); cerebellum: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000156876,SASS6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.342523,-0.356792,-0.465806
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,17.6,12.3,34.8,"thymus: 34.8 nTPM (manageable, limit 5); bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000156970,BUB1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7376% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.1020% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6301% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.1579% (minimum 99%, Baseline (adaptation disabled)); colon: 83.0769% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.7586% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.2030% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.6301% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6301% (minimum 99%, Baseline (adaptation disabled)); liver: 98.1818% (minimum 99%, Baseline (adaptation disabled)); lung: 96.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.7168% (minimum 97%, Baseline (adaptation disabled)); rectum: 78.8321% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 86.4000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.3750% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.5254% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.8049% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.3766% (minimum 97%, Baseline (adaptation disabled)); thymus: 38.2979% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.9130% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,17.6,12.3,34.8,"thymus: 34.8 nTPM (manageable, limit 5); bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000156970,BUB1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.567021,-0.332832,-0.43898
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7376% (minimum 99%, Missing); bone marrow: 55.1020% (minimum 99%, Missing); cerebral cortex: 98.6301% (minimum 99%, Missing); choroid plexus: 63.1579% (minimum 99%, Missing); colon: 83.0769% (minimum 97%, Missing); duodenum: 82.7586% (minimum 99%, Missing); esophagus: 81.2030% (minimum 97%, Missing); heart muscle: 98.6301% (minimum 99%, Missing); kidney: 98.6301% (minimum 99%, Missing); liver: 98.1818% (minimum 99%, Missing); lung: 96.0000% (minimum 99%, Missing); lymph node: 63.7168% (minimum 97%, Missing); rectum: 78.8321% (minimum 97%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); skin: 86.4000% (minimum 95%, Missing); small intestine: 84.3750% (minimum 99%, Missing); smooth muscle: 91.5254% (minimum 99%, Missing); spleen: 87.8049% (minimum 95%, Missing); stomach: 90.3766% (minimum 97%, Missing); thymus: 38.2979% (minimum 95%, Missing); urinary bladder: 93.9130% (minimum 97%, Missing)",0,80,unavailable,17.6,12.3,34.8,"thymus: 34.8 nTPM (manageable, limit 5); bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); small intestine: 4 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000156970,BUB1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.567021,-0.332832,-0.43898
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,34,21.1,31.7,"bone marrow: 34 nTPM (vital, limit 1); thymus: 31.7 nTPM (manageable, limit 5); spleen: 23.3 nTPM (manageable, limit 5); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 2); thyroid gland: 20.2 nTPM (manageable, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); skin: 20 nTPM (manageable, limit 5); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 2); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 2); kidney: 17.3 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 2); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 2); urinary bladder: 16 nTPM (protected, limit 2); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); colon: 15 nTPM (protected, limit 2); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 2); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 2); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000157014,TATDN2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.4396% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.9694% (minimum 99%, Baseline (adaptation disabled)); amygdala: 52.7594% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.3182% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 41.2781% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.0406% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.9595% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.4767% (minimum 99%, Baseline (adaptation disabled)); colon: 61.4396% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.0221% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.1963% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.3535% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.5662% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.7571% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.0097% (minimum 99%, Baseline (adaptation disabled)); liver: 63.5638% (minimum 99%, Baseline (adaptation disabled)); lung: 58.7224% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.1111% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.2396% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.3241% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.0097% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.0097% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.7297% (minimum 97%, Baseline (adaptation disabled)); retina: 73.3129% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.1509% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.4021% (minimum 99%, Baseline (adaptation disabled)); skin: 54.4419% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.6351% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.7696% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.0779% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.6356% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.6010% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.9856% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.1950% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.6793% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.8997% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,34,21.1,31.7,"bone marrow: 34 nTPM (vital, limit 1); thymus: 31.7 nTPM (manageable, limit 5); spleen: 23.3 nTPM (manageable, limit 5); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 2); thyroid gland: 20.2 nTPM (manageable, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); skin: 20 nTPM (manageable, limit 5); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 2); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 2); kidney: 17.3 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 2); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 2); urinary bladder: 16 nTPM (protected, limit 2); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); colon: 15 nTPM (protected, limit 2); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 2); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 2); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000157014,TATDN2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.520144,-0.438889,-0.577219
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.4396% (minimum 95%, Missing); adrenal gland: 60.9694% (minimum 99%, Missing); amygdala: 52.7594% (minimum 99%, Missing); basal ganglia: 54.3182% (minimum 99%, Missing); bone marrow: 41.2781% (minimum 99%, Missing); cerebellum: 57.0406% (minimum 99%, Missing); cerebral cortex: 50.9595% (minimum 99%, Missing); choroid plexus: 69.4767% (minimum 99%, Missing); colon: 61.4396% (minimum 97%, Missing); duodenum: 66.0221% (minimum 99%, Missing); esophagus: 55.1963% (minimum 97%, Missing); heart muscle: 60.3535% (minimum 99%, Missing); hippocampal formation: 54.5662% (minimum 99%, Missing); hypothalamus: 61.7571% (minimum 99%, Missing); kidney: 58.0097% (minimum 99%, Missing); liver: 63.5638% (minimum 99%, Missing); lung: 58.7224% (minimum 99%, Missing); lymph node: 53.1111% (minimum 97%, Missing); midbrain: 62.2396% (minimum 99%, Missing); pancreas: 55.3241% (minimum 99%, Missing); parathyroid gland: 58.0097% (minimum 97%, Missing); pituitary gland: 58.0097% (minimum 99%, Missing); rectum: 62.7297% (minimum 97%, Missing); retina: 73.3129% (minimum 99%, Missing); salivary gland: 58.1509% (minimum 97%, Missing); skeletal muscle: 62.4021% (minimum 99%, Missing); skin: 54.4419% (minimum 95%, Missing); small intestine: 56.6351% (minimum 99%, Missing); smooth muscle: 64.7696% (minimum 99%, Missing); spinal cord: 62.0779% (minimum 99%, Missing); spleen: 50.6356% (minimum 95%, Missing); stomach: 59.6010% (minimum 97%, Missing); thymus: 42.9856% (minimum 95%, Missing); thyroid gland: 54.1950% (minimum 95%, Missing); tongue: 69.6793% (minimum 97%, Missing); urinary bladder: 59.8997% (minimum 97%, Missing)",0,2,partial,34,21.1,31.7,"bone marrow: 34 nTPM (vital, limit 1); thymus: 31.7 nTPM (manageable, limit 5); spleen: 23.3 nTPM (manageable, limit 5); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 2); thyroid gland: 20.2 nTPM (manageable, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); skin: 20 nTPM (manageable, limit 5); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 2); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 2); kidney: 17.3 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 2); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 2); urinary bladder: 16 nTPM (protected, limit 2); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); colon: 15 nTPM (protected, limit 2); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 2); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 2); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000157014,TATDN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.520144,-0.438889,-0.577219
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,2,partial,0,0,0,,kidney / distal tubules: Medium (Enhanced),58,not_established,not_triggered,,,ENSG00000157060,SHCBP1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,0,0,0,,kidney / distal tubules: Medium (Enhanced),58,not_established,not_triggered,,,ENSG00000157060,SHCBP1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,0,0,0,,kidney / distal tubules: Medium (Enhanced),58,not_established,not_triggered,,,ENSG00000157060,SHCBP1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,1,0,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000157093,LYZL4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.0658% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,1,0,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000157093,LYZL4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0480315,0.03,-0.00934236
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.0658% (minimum 99%, Missing)",0,1,partial,1,0,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000157093,LYZL4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00934236
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,16.5,8.9,9.4,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 2); kidney: 8 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000157168,NRG1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.6709% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.0588% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.8447% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.4348% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.0575% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.5185% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.3643% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 71.1538% (minimum 99%, Baseline (adaptation disabled)); colon: 72.5490% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.8947% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.4348% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.8947% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 38.7435% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.0519% (minimum 99%, Baseline (adaptation disabled)); liver: 30.9623% (minimum 99%, Baseline (adaptation disabled)); lung: 68.5185% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.1039% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.7931% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.5000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.5000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.2727% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.8447% (minimum 97%, Baseline (adaptation disabled)); retina: 39.5722% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.7475% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 61.1570% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.2887% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.0952% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.7234% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.1461% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.8947% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.2439% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 44.0476% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 45.3988% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,16.5,8.9,9.4,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 2); kidney: 8 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000157168,NRG1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.509524,-0.516012,-0.680377
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.6709% (minimum 95%, Uncertain); adrenal gland: 87.0588% (minimum 99%, Uncertain); amygdala: 71.8447% (minimum 99%, Missing); basal ganglia: 80.4348% (minimum 99%, Missing); bone marrow: 85.0575% (minimum 99%, Missing); cerebellum: 68.5185% (minimum 99%, Missing); cerebral cortex: 57.3643% (minimum 99%, Missing); choroid plexus: 71.1538% (minimum 99%, Missing); colon: 72.5490% (minimum 97%, Uncertain); duodenum: 77.8947% (minimum 99%, Uncertain); esophagus: 74.0000% (minimum 97%, Uncertain); heart muscle: 80.4348% (minimum 99%, Uncertain); hippocampal formation: 77.8947% (minimum 99%, Missing); hypothalamus: 38.7435% (minimum 99%, Missing); kidney: 48.0519% (minimum 99%, Uncertain); liver: 30.9623% (minimum 99%, Uncertain); lung: 68.5185% (minimum 99%, Uncertain); lymph node: 96.1039% (minimum 97%, Missing); midbrain: 63.7931% (minimum 99%, Missing); pancreas: 92.5000% (minimum 99%, Uncertain); parathyroid gland: 92.5000% (minimum 97%, Missing); pituitary gland: 67.2727% (minimum 99%, Missing); rectum: 71.8447% (minimum 97%, Uncertain); retina: 39.5722% (minimum 99%, Missing); salivary gland: 74.7475% (minimum 97%, Uncertain); skeletal muscle: 98.6667% (minimum 99%, Uncertain); skin: 61.1570% (minimum 95%, Missing); small intestine: 76.2887% (minimum 99%, Uncertain); smooth muscle: 88.0952% (minimum 99%, Uncertain); spinal cord: 78.7234% (minimum 99%, Missing); spleen: 83.1461% (minimum 95%, Missing); stomach: 77.8947% (minimum 97%, Uncertain); thymus: 90.2439% (minimum 95%, Missing); thyroid gland: 44.0476% (minimum 95%, Uncertain); urinary bladder: 45.3988% (minimum 97%, Uncertain)",0,2,partial,16.5,8.9,9.4,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 2); kidney: 8 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000157168,NRG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.509524,-0.516012,-0.680377
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,23.2,0.6,1.2,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157322,CLEC18A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.9394% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 77.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.1765% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.4872% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.5714% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.8750% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 16.3158% (minimum 99%, Baseline (adaptation disabled)); colon: 88.5714% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.8750% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.8750% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.8750% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.5714% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.7838% (minimum 99%, Baseline (adaptation disabled)); kidney: 11.7871% (minimum 99%, Baseline (adaptation disabled)); liver: 93.9394% (minimum 99%, Baseline (adaptation disabled)); lung: 88.5714% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.9394% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.5714% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.5714% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.8750% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.5714% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.8750% (minimum 97%, Baseline (adaptation disabled)); retina: 96.8750% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.7838% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.9394% (minimum 99%, Baseline (adaptation disabled)); skin: 91.1765% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.5789% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.8095% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.0930% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.1111% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.9394% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.5714% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 91.1765% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,23.2,0.6,1.2,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157322,CLEC18A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.22907,-0.132162,-0.872129
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.9394% (minimum 95%, Missing); adrenal gland: 77.5000% (minimum 99%, Missing); amygdala: 91.1765% (minimum 99%, Missing); basal ganglia: 79.4872% (minimum 99%, Missing); bone marrow: 88.5714% (minimum 99%, Missing); cerebellum: 96.8750% (minimum 99%, Missing); cerebral cortex: 88.5714% (minimum 99%, Missing); choroid plexus: 16.3158% (minimum 99%, Missing); colon: 88.5714% (minimum 97%, Missing); duodenum: 96.8750% (minimum 99%, Missing); esophagus: 96.8750% (minimum 97%, Missing); heart muscle: 96.8750% (minimum 99%, Missing); hippocampal formation: 88.5714% (minimum 99%, Missing); hypothalamus: 83.7838% (minimum 99%, Missing); kidney: 11.7871% (minimum 99%, Missing); liver: 93.9394% (minimum 99%, Missing); lung: 88.5714% (minimum 99%, Missing); lymph node: 93.9394% (minimum 97%, Missing); midbrain: 88.5714% (minimum 99%, Missing); pancreas: 88.5714% (minimum 99%, Missing); parathyroid gland: 96.8750% (minimum 97%, Missing); pituitary gland: 88.5714% (minimum 99%, Missing); rectum: 96.8750% (minimum 97%, Missing); retina: 96.8750% (minimum 99%, Missing); salivary gland: 83.7838% (minimum 97%, Missing); skeletal muscle: 93.9394% (minimum 99%, Missing); skin: 91.1765% (minimum 95%, Missing); small intestine: 81.5789% (minimum 99%, Missing); spinal cord: 73.8095% (minimum 99%, Missing); spleen: 72.0930% (minimum 95%, Missing); stomach: 86.1111% (minimum 97%, Missing); thymus: 93.9394% (minimum 95%, Missing); thyroid gland: 88.5714% (minimum 95%, Missing); urinary bladder: 91.1765% (minimum 97%, Missing)",0,80,unavailable,23.2,0.6,1.2,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157322,CLEC18A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.22907,-0.132162,-0.872129
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,45.3,0.1,0.6,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000157330,CFAP107,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.9381% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.7661% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 51.1853% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.3489% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.8104% (minimum 99%, Baseline (adaptation disabled)); lung: 96.3489% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.7526% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.5359% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,45.3,0.1,0.6,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000157330,CFAP107,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.037526,0.0278992,-0.478147
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.9381% (minimum 99%, Missing); basal ganglia: 95.7661% (minimum 99%, Missing); choroid plexus: 51.1853% (minimum 99%, Missing); hippocampal formation: 96.3489% (minimum 99%, Missing); hypothalamus: 94.8104% (minimum 99%, Missing); lung: 96.3489% (minimum 99%, Missing); pituitary gland: 98.7526% (minimum 99%, Missing); skeletal muscle: 97.5359% (minimum 99%, Missing)",0,80,unavailable,45.3,0.1,0.6,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000157330,CFAP107,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.037526,0.0278992,-0.478147
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,10.9,1.4,2.9,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157343,ARMC12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7055% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.5455% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.5782% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1132% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.1479% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.0354% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.4451% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.7055% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.8056% (minimum 99%, Baseline (adaptation disabled)); liver: 93.4132% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1132% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.5944% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1132% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 85.1296% (minimum 99%, Baseline (adaptation disabled)); retina: 97.9592% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.1963% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.8944% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,10.9,1.4,2.9,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157343,ARMC12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00558959,0.00805643,-0.138704
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.7055% (minimum 99%, Missing); basal ganglia: 94.5455% (minimum 99%, Missing); choroid plexus: 92.0354% (minimum 99%, Missing); hippocampal formation: 96.4451% (minimum 99%, Missing); hypothalamus: 95.7055% (minimum 99%, Missing); liver: 93.4132% (minimum 95%, Enhanced); midbrain: 96.5944% (minimum 99%, Missing); pituitary gland: 85.1296% (minimum 99%, Missing); retina: 97.9592% (minimum 99%, Missing); spinal cord: 96.8944% (minimum 99%, Missing)",0,3,partial,10.9,1.4,2.9,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157343,ARMC12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00558959,0.00805643,-0.138704
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,13,partial,6.6,2.4,1.8,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000157423,HYDIN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.5455% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.5455% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.2500% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.2394% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.2281% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.5397% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.2500% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 61.9048% (minimum 99%, Baseline (adaptation disabled)); colon: 89.6552% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.2963% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 91.2281% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.2857% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.2329% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 92.8571% (minimum 99%, Baseline (adaptation disabled)); lung: 78.7879% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.2963% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.8710% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.1356% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.4211% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.3191% (minimum 99%, Baseline (adaptation disabled)); retina: 44.0678% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.5455% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.1132% (minimum 99%, Baseline (adaptation disabled)); skin: 91.2281% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.2963% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.2963% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.2500% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.8571% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.2963% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 74.2857% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.8571% (minimum 97%, Baseline (adaptation disabled))",0,13,partial,6.6,2.4,1.8,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000157423,HYDIN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.207143,-0.285789,-0.549322
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.5455% (minimum 95%, Enhanced); amygdala: 81.2500% (minimum 99%, Missing); basal ganglia: 73.2394% (minimum 99%, Missing); bone marrow: 91.2281% (minimum 95%, Enhanced); cerebellum: 82.5397% (minimum 95%, Enhanced); cerebral cortex: 81.2500% (minimum 95%, Enhanced); choroid plexus: 61.9048% (minimum 99%, Missing); colon: 89.6552% (minimum 97%, Missing); duodenum: 96.2963% (minimum 99%, Missing); heart muscle: 91.2281% (minimum 95%, Enhanced); hippocampal formation: 74.2857% (minimum 99%, Missing); hypothalamus: 71.2329% (minimum 99%, Missing); kidney: 80.0000% (minimum 95%, Enhanced); liver: 92.8571% (minimum 95%, Enhanced); lung: 78.7879% (minimum 95%, Enhanced); lymph node: 96.2963% (minimum 97%, Missing); midbrain: 83.8710% (minimum 99%, Missing); pancreas: 88.1356% (minimum 95%, Enhanced); parathyroid gland: 68.4211% (minimum 80%, Enhanced); pituitary gland: 55.3191% (minimum 99%, Missing); retina: 44.0678% (minimum 99%, Missing); small intestine: 96.2963% (minimum 99%, Missing); spinal cord: 81.2500% (minimum 99%, Missing)",0,13,partial,6.6,2.4,1.8,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000157423,HYDIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0311321,-0.115789,-0.549322
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,10.6,4.2,7.8,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 2); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); skin: 6.2 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); lung: 4.2 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); stomach: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 2); colon: 2.3 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000157429,ZNF19,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.8877% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.1648% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.8144% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.1765% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.6354% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.5122% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.1144% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.2653% (minimum 99%, Baseline (adaptation disabled)); colon: 87.0787% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.1518% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.6802% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.0816% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.2619% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.1765% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.0106% (minimum 99%, Baseline (adaptation disabled)); liver: 88.0682% (minimum 99%, Baseline (adaptation disabled)); lung: 78.6802% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.2391% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.9394% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.0930% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.6802% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 74.8792% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.5714% (minimum 97%, Baseline (adaptation disabled)); retina: 59.3870% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.4468% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 71.4286% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.2391% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.1765% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.3735% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.1648% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.1648% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.9394% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.5236% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.1163% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.6433% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,10.6,4.2,7.8,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); skin: 6.2 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); bone marrow: 2.6 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000157429,ZNF19,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.284764,-0.183198,-0.39613
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.8877% (minimum 90%, Approved); adrenal gland: 85.1648% (minimum 99%, Missing); amygdala: 92.8144% (minimum 99%, Missing); basal ganglia: 91.1765% (minimum 99%, Missing); bone marrow: 85.6354% (minimum 98%, Approved); cerebellum: 94.5122% (minimum 99%, Missing); cerebral cortex: 77.1144% (minimum 98%, Approved); choroid plexus: 63.2653% (minimum 99%, Missing); colon: 87.0787% (minimum 97%, Missing); duodenum: 81.1518% (minimum 99%, Missing); esophagus: 78.6802% (minimum 97%, Missing); heart muscle: 79.0816% (minimum 99%, Missing); hippocampal formation: 92.2619% (minimum 99%, Missing); hypothalamus: 91.1765% (minimum 99%, Missing); kidney: 82.0106% (minimum 99%, Missing); liver: 88.0682% (minimum 99%, Missing); lung: 78.6802% (minimum 99%, Missing); lymph node: 84.2391% (minimum 97%, Missing); midbrain: 93.9394% (minimum 99%, Missing); pancreas: 72.0930% (minimum 99%, Missing); parathyroid gland: 78.6802% (minimum 97%, Missing); pituitary gland: 74.8792% (minimum 99%, Missing); rectum: 88.5714% (minimum 97%, Missing); retina: 59.3870% (minimum 99%, Missing); salivary gland: 82.4468% (minimum 97%, Missing); skeletal muscle: 62.5000% (minimum 98%, Approved); skin: 71.4286% (minimum 95%, Missing); small intestine: 84.2391% (minimum 99%, Missing); smooth muscle: 91.1765% (minimum 98%, Approved); spinal cord: 93.3735% (minimum 99%, Missing); spleen: 85.1648% (minimum 95%, Missing); stomach: 85.1648% (minimum 97%, Missing); thymus: 93.9394% (minimum 95%, Missing); thyroid gland: 66.5236% (minimum 95%, Missing); tongue: 90.1163% (minimum 97%, Missing); urinary bladder: 90.6433% (minimum 97%, Missing)",0,5,partial,10.6,4.2,7.8,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 2); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); skin: 6.2 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); lung: 4.2 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); stomach: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 2); colon: 2.3 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000157429,ZNF19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.284764,-0.183198,-0.39613
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,16.2,10.3,0.4,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 2); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157445,CACNA2D3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.8889% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 28.5714% (minimum 99%, Baseline (adaptation disabled)); amygdala: 33.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 8.9888% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 42.1053% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 9.0909% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 72.7273% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.1176% (minimum 99%, Baseline (adaptation disabled)); esophagus: 76.1905% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 39.0244% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 17.3913% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 19.0476% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 99%, Baseline (adaptation disabled)); lung: 76.1905% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.1905% (minimum 97%, Baseline (adaptation disabled)); midbrain: 41.0256% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.2105% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.2105% (minimum 97%, Baseline (adaptation disabled)); retina: 36.3636% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 14.4144% (minimum 99%, Baseline (adaptation disabled)); skin: 94.1176% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.2105% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.7273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.5385% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.8889% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.1176% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 80.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 13.4454% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.1176% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,16.2,10.3,0.4,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 2); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157445,CACNA2D3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.15,-0.835546,-0.900112
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.8889% (minimum 95%, Missing); adrenal gland: 28.5714% (minimum 99%, Missing); amygdala: 33.3333% (minimum 99%, Missing); basal ganglia: 8.9888% (minimum 99%, Missing); cerebellum: 42.1053% (minimum 99%, Missing); cerebral cortex: 9.0909% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 72.7273% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); esophagus: 76.1905% (minimum 97%, Missing); heart muscle: 39.0244% (minimum 99%, Missing); hippocampal formation: 17.3913% (minimum 99%, Missing); hypothalamus: 19.0476% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); lung: 76.1905% (minimum 99%, Missing); lymph node: 76.1905% (minimum 97%, Missing); midbrain: 41.0256% (minimum 99%, Missing); parathyroid gland: 84.2105% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 84.2105% (minimum 97%, Missing); retina: 36.3636% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 14.4144% (minimum 99%, Missing); skin: 94.1176% (minimum 95%, Missing); small intestine: 84.2105% (minimum 99%, Missing); smooth muscle: 72.7273% (minimum 99%, Missing); spinal cord: 61.5385% (minimum 99%, Missing); spleen: 88.8889% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thymus: 94.1176% (minimum 95%, Missing); thyroid gland: 80.0000% (minimum 95%, Missing); tongue: 13.4454% (minimum 97%, Missing); urinary bladder: 94.1176% (minimum 97%, Missing)",0,80,unavailable,16.2,10.3,0.4,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 2); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157445,CACNA2D3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.15,-0.835546,-0.900112
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,12,partial,73.6,32.2,71.2,"bone marrow: 73.6 nTPM (vital, limit 1); thymus: 71.2 nTPM (manageable, limit 5); lymph node: 32.2 nTPM (protected, limit 2); rectum: 16.3 nTPM (protected, limit 2); esophagus: 15.7 nTPM (protected, limit 2); colon: 13.8 nTPM (protected, limit 2); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 11.7 nTPM (vital, limit 1); skin: 9.2 nTPM (manageable, limit 5); spleen: 6.9 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / eccrine glands: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),91,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / eccrine glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000157456,CCNB2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.5380% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 47.8014% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6823% (minimum 99%, Baseline (adaptation disabled)); colon: 83.0049% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.1073% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.1071% (minimum 97%, Baseline (adaptation disabled)); kidney: 98.3942% (minimum 99%, Baseline (adaptation disabled)); liver: 97.9651% (minimum 99%, Baseline (adaptation disabled)); lung: 96.9784% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.6707% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.9721% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.5257% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.1484% (minimum 97%, Baseline (adaptation disabled)); skin: 87.9896% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.2086% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.5761% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.7133% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.5824% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.6291% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.0635% (minimum 97%, Baseline (adaptation disabled))",0,12,partial,73.6,32.2,71.2,"bone marrow: 73.6 nTPM (vital, limit 1); thymus: 71.2 nTPM (manageable, limit 5); lymph node: 32.2 nTPM (protected, limit 2); rectum: 16.3 nTPM (protected, limit 2); esophagus: 15.7 nTPM (protected, limit 2); colon: 13.8 nTPM (protected, limit 2); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 11.7 nTPM (vital, limit 1); skin: 9.2 nTPM (manageable, limit 5); spleen: 6.9 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / eccrine glands: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),91,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / eccrine glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000157456,CCNB2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.463709,-0.293293,-0.511986
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.5380% (minimum 99%, Missing); bone marrow: 47.8014% (minimum 99%, Missing); cerebral cortex: 98.6823% (minimum 99%, Missing); colon: 83.0049% (minimum 97%, Missing); duodenum: 83.1073% (minimum 99%, Missing); esophagus: 81.1071% (minimum 97%, Missing); kidney: 98.3942% (minimum 99%, Missing); lymph node: 67.6707% (minimum 97%, Missing); pancreas: 98.9721% (minimum 99%, Missing); rectum: 80.5257% (minimum 97%, Missing); skin: 87.9896% (minimum 95%, Missing); small intestine: 85.2086% (minimum 99%, Missing); smooth muscle: 91.5761% (minimum 99%, Missing); spleen: 90.7133% (minimum 95%, Missing); stomach: 92.5824% (minimum 97%, Missing); thymus: 48.6291% (minimum 95%, Missing); urinary bladder: 95.0635% (minimum 97%, Missing)",0,12,partial,73.6,32.2,71.2,"bone marrow: 73.6 nTPM (vital, limit 1); thymus: 71.2 nTPM (manageable, limit 5); lymph node: 32.2 nTPM (protected, limit 2); rectum: 16.3 nTPM (protected, limit 2); esophagus: 15.7 nTPM (protected, limit 2); colon: 13.8 nTPM (protected, limit 2); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 11.7 nTPM (vital, limit 1); skin: 9.2 nTPM (manageable, limit 5); spleen: 6.9 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / eccrine glands: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),91,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / eccrine glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000157456,CCNB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.463709,-0.293293,-0.511986
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,9,partial,10.5,2.2,4.2,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157578,LCA5L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.5294% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.8018% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9843% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.8102% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8930% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7109% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.8995% (minimum 99%, Baseline (adaptation disabled)); lung: 98.7109% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.8018% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.1685% (minimum 99%, Baseline (adaptation disabled)); retina: 91.0790% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.0787% (minimum 99%, Baseline (adaptation disabled))",0,9,partial,10.5,2.2,4.2,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157578,LCA5L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,0.012298,0.00989031,-0.0792099
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.8018% (minimum 99%, Missing); choroid plexus: 97.8102% (minimum 99%, Missing); hippocampal formation: 98.8930% (minimum 99%, Missing); hypothalamus: 98.7109% (minimum 99%, Missing); kidney: 97.8995% (minimum 99%, Missing); pituitary gland: 98.1685% (minimum 99%, Missing); retina: 91.0790% (minimum 99%, Missing)",0,9,partial,10.5,2.2,4.2,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157578,LCA5L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,0.0472093,0.00989031,-0.0792099
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.9,0.9,0.7,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157653,C9orf43,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9365% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.6637% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.8839% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.8874% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.1491% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.6637% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.6637% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.3626% (minimum 99%, Baseline (adaptation disabled)); liver: 96.7249% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.6637% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2262% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1491% (minimum 99%, Baseline (adaptation disabled)); retina: 97.3626% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.4444% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.9,0.9,0.7,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157653,C9orf43,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0344444,0.0100885,-0.0311255
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9365% (minimum 99%, Missing); amygdala: 98.6637% (minimum 99%, Missing); basal ganglia: 98.8839% (minimum 99%, Missing); bone marrow: 95.8874% (minimum 99%, Missing); choroid plexus: 97.1491% (minimum 99%, Missing); hippocampal formation: 98.6637% (minimum 99%, Missing); hypothalamus: 98.6637% (minimum 99%, Missing); kidney: 97.3626% (minimum 99%, Missing); liver: 96.7249% (minimum 99%, Missing); midbrain: 98.6637% (minimum 99%, Missing); pancreas: 98.2262% (minimum 99%, Missing); pituitary gland: 97.1491% (minimum 99%, Missing); retina: 97.3626% (minimum 99%, Missing); spinal cord: 98.4444% (minimum 99%, Missing)",0,80,unavailable,1.9,0.9,0.7,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000157653,C9orf43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0344444,0.0100885,-0.0311255
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.8,4,0.7,"choroid plexus: 8.8 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,ENSG00000157703,SVOPL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.8182% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.7143% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 16.9811% (minimum 99%, Baseline (adaptation disabled)); colon: 69.2308% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.7368% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.7368% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.8182% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 40.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 90.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.7368% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.2609% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 31.0345% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.7143% (minimum 97%, Baseline (adaptation disabled)); retina: 36.7347% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 31.5789% (minimum 97%, Baseline (adaptation disabled)); skin: 85.7143% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.8182% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.7368% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.7368% (minimum 97%, Baseline (adaptation disabled)); thymus: 81.8182% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 72.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 81.8182% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.8,4,0.7,"choroid plexus: 8.8 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,ENSG00000157703,SVOPL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.23,-0.659655,-0.820189
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 99%, Missing); amygdala: 90.0000% (minimum 99%, Missing); basal ganglia: 81.8182% (minimum 99%, Missing); bone marrow: 90.0000% (minimum 99%, Missing); cerebral cortex: 85.7143% (minimum 99%, Missing); choroid plexus: 16.9811% (minimum 99%, Missing); colon: 69.2308% (minimum 97%, Missing); duodenum: 94.7368% (minimum 99%, Missing); esophagus: 94.7368% (minimum 97%, Missing); heart muscle: 90.0000% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 85.7143% (minimum 99%, Missing); kidney: 40.0000% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); midbrain: 94.7368% (minimum 99%, Missing); pancreas: 78.2609% (minimum 99%, Missing); parathyroid gland: 31.0345% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 85.7143% (minimum 97%, Missing); retina: 36.7347% (minimum 99%, Missing); salivary gland: 31.5789% (minimum 97%, Missing); skin: 85.7143% (minimum 95%, Missing); small intestine: 90.0000% (minimum 99%, Missing); spinal cord: 81.8182% (minimum 99%, Missing); spleen: 94.7368% (minimum 95%, Missing); stomach: 94.7368% (minimum 97%, Missing); thymus: 81.8182% (minimum 95%, Missing); thyroid gland: 72.0000% (minimum 95%, Missing); urinary bladder: 81.8182% (minimum 97%, Missing)",0,80,unavailable,8.8,4,0.7,"choroid plexus: 8.8 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,ENSG00000157703,SVOPL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.23,-0.659655,-0.820189
True,compatible,,True,True,False,,0,80,unavailable,0.9,0.2,2.4,,,0,not_established,not_triggered,,,ENSG00000157884,CIB4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 96.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.9153% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8235% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 87.5000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.9,0.2,2.4,,,0,not_established,not_triggered,,,ENSG00000157884,CIB4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.075,0.0182353,-0.0408475
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 96.0000% (minimum 99%, Missing); choroid plexus: 94.9153% (minimum 99%, Missing); lung: 98.8235% (minimum 99%, Missing); thyroid gland: 87.5000% (minimum 95%, Missing)",0,80,unavailable,0.9,0.2,2.4,,,0,not_established,not_triggered,,,ENSG00000157884,CIB4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.075,0.0182353,-0.0408475
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,5.7,3.9,8.6,"thymus: 8.6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000158402,CDC25C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8701% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.4310% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.8701% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.3146% (minimum 99%, Baseline (adaptation disabled)); colon: 84.1346% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.7843% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.5926% (minimum 97%, Baseline (adaptation disabled)); liver: 97.2222% (minimum 99%, Baseline (adaptation disabled)); lung: 98.3146% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.9515% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.3146% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.7757% (minimum 97%, Baseline (adaptation disabled)); skin: 93.0851% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.7843% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.0860% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.0498% (minimum 95%, Baseline (adaptation disabled))",0,8,partial,5.7,3.9,8.6,"thymus: 8.6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000158402,CDC25C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.279502,-0.152243,-0.23569
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8701% (minimum 99%, Missing); bone marrow: 75.4310% (minimum 99%, Missing); cerebral cortex: 98.8701% (minimum 99%, Missing); choroid plexus: 98.3146% (minimum 99%, Missing); colon: 84.1346% (minimum 97%, Missing); duodenum: 85.7843% (minimum 99%, Missing); esophagus: 92.5926% (minimum 97%, Missing); liver: 97.2222% (minimum 98%, Approved); lung: 98.3146% (minimum 99%, Missing); lymph node: 84.9515% (minimum 97%, Missing); pancreas: 98.3146% (minimum 99%, Missing); rectum: 81.7757% (minimum 97%, Missing); skin: 93.0851% (minimum 95%, Missing); small intestine: 85.7843% (minimum 99%, Missing); smooth muscle: 96.1538% (minimum 98%, Approved); stomach: 94.0860% (minimum 97%, Missing); thymus: 67.0498% (minimum 95%, Missing)",0,8,partial,5.7,3.9,8.6,"thymus: 8.6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000158402,CDC25C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.279502,-0.152243,-0.23569
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,27.4,2.5,3.4,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000158423,RIBC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.9524% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.8575% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.9524% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.4536% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.9487% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.9543% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.2317% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.6982% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.2010% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.2705% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.5213% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.4939% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2005% (minimum 99%, Baseline (adaptation disabled)); lung: 92.2705% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.0887% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.5000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.8575% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.6502% (minimum 99%, Baseline (adaptation disabled)); retina: 77.6423% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.2618% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.2005% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.9487% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.4536% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.7891% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 91.8269% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,27.4,2.5,3.4,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000158423,RIBC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0317308,-0.0314251,-0.407683
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.9524% (minimum 99%, Missing); amygdala: 93.8575% (minimum 99%, Missing); basal ganglia: 90.9524% (minimum 99%, Missing); bone marrow: 98.4536% (minimum 99%, Missing); cerebellum: 97.9487% (minimum 99%, Missing); cerebral cortex: 96.9543% (minimum 99%, Missing); choroid plexus: 58.2317% (minimum 99%, Missing); duodenum: 97.6982% (minimum 99%, Missing); heart muscle: 97.2010% (minimum 99%, Missing); hippocampal formation: 92.2705% (minimum 99%, Missing); hypothalamus: 90.5213% (minimum 99%, Missing); kidney: 92.4939% (minimum 99%, Missing); liver: 98.2005% (minimum 99%, Missing); lung: 92.2705% (minimum 99%, Missing); midbrain: 94.0887% (minimum 99%, Missing); pancreas: 95.5000% (minimum 99%, Missing); parathyroid gland: 93.8575% (minimum 97%, Missing); pituitary gland: 85.6502% (minimum 99%, Missing); retina: 77.6423% (minimum 99%, Missing); salivary gland: 95.2618% (minimum 97%, Missing); skeletal muscle: 98.2005% (minimum 99%, Missing); small intestine: 97.9487% (minimum 99%, Missing); smooth muscle: 98.4536% (minimum 99%, Missing); spinal cord: 94.7891% (minimum 99%, Missing); thyroid gland: 91.8269% (minimum 95%, Missing)",0,80,unavailable,27.4,2.5,3.4,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000158423,RIBC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0317308,-0.0314251,-0.407683
True,compatible,,True,True,False,,0,80,unavailable,0.9,0.6,2.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus; tonsil,ENSG00000158497,HMHB1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 81.2500% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 59.0909% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.4211% (minimum 97%, Baseline (adaptation disabled)); thymus: 36.1111% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.8571% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.9,0.6,2.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus; tonsil,ENSG00000158497,HMHB1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.588889,-0.285789,-0.399091
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 81.2500% (minimum 95%, Missing); bone marrow: 59.0909% (minimum 99%, Missing); heart muscle: 92.8571% (minimum 99%, Missing); lymph node: 68.4211% (minimum 97%, Missing); thymus: 36.1111% (minimum 95%, Missing); thyroid gland: 92.8571% (minimum 95%, Missing)",0,80,unavailable,0.9,0.6,2.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus; tonsil,ENSG00000158497,HMHB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.588889,-0.285789,-0.399091
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.2,1.8,2.2,"pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000158525,CPA5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 98.1982% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.7826% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.4940% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.4602% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.1982% (minimum 99%, Baseline (adaptation disabled)); thymus: 93.6963% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.2,1.8,2.2,"pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000158525,CPA5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,-0.0130372,-0.0221739,-0.0253982
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 98.1982% (minimum 99%, Missing); lymph node: 94.7826% (minimum 97%, Missing); pancreas: 98.4940% (minimum 99%, Missing); pituitary gland: 96.4602% (minimum 99%, Missing); small intestine: 98.1982% (minimum 99%, Missing); thymus: 93.6963% (minimum 95%, Missing)",0,80,unavailable,1.2,1.8,2.2,"pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000158525,CPA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,-0.0130372,-0.0221739,-0.0253982
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000158553,POM121L2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000158553,POM121L2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000158553,POM121L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,1,0.3,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000158639,PAGE5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 96.2687% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8506% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,1,0.3,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000158639,PAGE5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.046139,0.0185057,-0.0273134
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 96.2687% (minimum 97%, Supported)",0,2,partial,1,0.3,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000158639,PAGE5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.046139,0.03,-0.00731343
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.7,2.5,1.4,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000158683,PKD1L1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.1538% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.3077% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.5882% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.5455% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 80.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 31.5789% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 70.5882% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.3077% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 41.3793% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 30.7692% (minimum 99%, Baseline (adaptation disabled)); skin: 70.5882% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.7143% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 32.4324% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.7,2.5,1.4,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000158683,PKD1L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.488462,-0.645676,-0.682308
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.1538% (minimum 95%, Missing); adrenal gland: 92.3077% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 70.5882% (minimum 99%, Missing); bone marrow: 54.5455% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); cerebral cortex: 80.0000% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 80.0000% (minimum 97%, Missing); heart muscle: 31.5789% (minimum 99%, Missing); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 80.0000% (minimum 99%, Missing); liver: 70.5882% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 80.0000% (minimum 99%, Missing); parathyroid gland: 92.3077% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 41.3793% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 30.7692% (minimum 99%, Missing); skin: 70.5882% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 85.7143% (minimum 95%, Missing); stomach: 75.0000% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing); thyroid gland: 75.0000% (minimum 95%, Missing); tongue: 32.4324% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,80,unavailable,2.7,2.5,1.4,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); tongue: 2.5 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000158683,PKD1L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.488462,-0.645676,-0.682308
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,71.4,83.1,46.8,"esophagus: 83.1 nTPM (protected, limit 2); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 2); colon: 51 nTPM (protected, limit 2); urinary bladder: 50.3 nTPM (protected, limit 2); rectum: 50.1 nTPM (protected, limit 2); salivary gland: 47.9 nTPM (protected, limit 2); skin: 46.8 nTPM (manageable, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (manageable, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 2); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); pituitary gland: 18.3 nTPM (vital, limit 1); thymus: 16 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 2); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 6); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 2); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000158769,F11R,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 70.6052% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.4003% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.2394% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.0735% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.9001% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.2308% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.4179% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.4165% (minimum 99%, Baseline (adaptation disabled)); colon: 49.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 47.4347% (minimum 99%, Baseline (adaptation disabled)); esophagus: 37.0931% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.8046% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.4161% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.4059% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.5556% (minimum 99%, Baseline (adaptation disabled)); liver: 40.6977% (minimum 99%, Baseline (adaptation disabled)); lung: 42.9448% (minimum 99%, Baseline (adaptation disabled)); lymph node: 79.1599% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.4477% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.7486% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.2640% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.8083% (minimum 99%, Baseline (adaptation disabled)); rectum: 49.4450% (minimum 97%, Baseline (adaptation disabled)); retina: 95.8904% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.5676% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.4161% (minimum 99%, Baseline (adaptation disabled)); skin: 51.1482% (minimum 95%, Baseline (adaptation disabled)); small intestine: 44.1441% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.9220% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.6076% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.8534% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.3846% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.2572% (minimum 95%, Baseline (adaptation disabled)); tongue: 89.0909% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 49.3454% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,71.4,83.1,46.8,"esophagus: 83.1 nTPM (protected, limit 2); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 2); colon: 51 nTPM (protected, limit 2); urinary bladder: 50.3 nTPM (protected, limit 2); rectum: 50.1 nTPM (protected, limit 2); salivary gland: 47.9 nTPM (protected, limit 2); skin: 46.8 nTPM (manageable, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (manageable, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 2); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); adipose tissue: 20.4 nTPM (manageable, limit 5); pituitary gland: 18.3 nTPM (vital, limit 1); thymus: 16 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 2); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 2); skeletal muscle: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000158769,F11R,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.438518,-0.599069,-0.583023
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.4003% (minimum 99%, Missing); amygdala: 90.2394% (minimum 99%, Missing); basal ganglia: 90.0735% (minimum 99%, Missing); bone marrow: 69.9001% (minimum 99%, Missing); cerebellum: 94.2308% (minimum 95%, Enhanced); cerebral cortex: 91.4179% (minimum 99%, Missing); choroid plexus: 79.4165% (minimum 99%, Missing); colon: 49.0000% (minimum 97%, Missing); duodenum: 47.4347% (minimum 99%, Missing); esophagus: 37.0931% (minimum 97%, Missing); heart muscle: 79.8046% (minimum 99%, Missing); hippocampal formation: 89.4161% (minimum 99%, Missing); hypothalamus: 90.4059% (minimum 99%, Missing); kidney: 55.5556% (minimum 99%, Missing); liver: 40.6977% (minimum 99%, Missing); lung: 42.9448% (minimum 99%, Missing); lymph node: 79.1599% (minimum 97%, Missing); midbrain: 88.4477% (minimum 99%, Missing); pancreas: 54.7486% (minimum 99%, Missing); parathyroid gland: 58.2640% (minimum 97%, Missing); pituitary gland: 72.8083% (minimum 99%, Missing); rectum: 49.4450% (minimum 97%, Missing); retina: 95.8904% (minimum 99%, Missing); salivary gland: 50.5676% (minimum 97%, Missing); skeletal muscle: 89.4161% (minimum 95%, Enhanced); skin: 51.1482% (minimum 95%, Missing); small intestine: 44.1441% (minimum 99%, Missing); smooth muscle: 84.9220% (minimum 95%, Enhanced); spinal cord: 88.6076% (minimum 99%, Missing); spleen: 70.0000% (minimum 95%, Missing); stomach: 48.8534% (minimum 97%, Missing); thymus: 75.3846% (minimum 95%, Missing); thyroid gland: 56.2572% (minimum 95%, Missing); tongue: 89.0909% (minimum 97%, Missing); urinary bladder: 49.3454% (minimum 97%, Missing)",0,6,partial,71.4,83.1,46.8,"esophagus: 83.1 nTPM (protected, limit 2); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 2); colon: 51 nTPM (protected, limit 2); urinary bladder: 50.3 nTPM (protected, limit 2); rectum: 50.1 nTPM (protected, limit 2); salivary gland: 47.9 nTPM (protected, limit 2); skin: 46.8 nTPM (manageable, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (manageable, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 2); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); pituitary gland: 18.3 nTPM (vital, limit 1); thymus: 16 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 2); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 6); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 2); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000158769,F11R,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.438518,-0.599069,-0.583023
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,17.3,20.6,14.6,"lymph node: 20.6 nTPM (protected, limit 2); cerebellum: 17.3 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 2); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000158987,RAPGEF6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.6410% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.6587% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.6234% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.1242% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.7603% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 40.5498% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.5556% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.7647% (minimum 99%, Baseline (adaptation disabled)); colon: 71.0843% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.1290% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.1592% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.7297% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.2138% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.9512% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.6835% (minimum 99%, Baseline (adaptation disabled)); liver: 65.1934% (minimum 99%, Baseline (adaptation disabled)); lung: 63.7838% (minimum 99%, Baseline (adaptation disabled)); lymph node: 36.4198% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.2138% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.2138% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.4809% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.8219% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.6047% (minimum 97%, Baseline (adaptation disabled)); retina: 59.8985% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.1592% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.6316% (minimum 99%, Baseline (adaptation disabled)); skin: 72.3926% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.6835% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.1592% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.8225% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.8431% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.9512% (minimum 97%, Baseline (adaptation disabled)); thymus: 44.6970% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.0843% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.1457% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.6047% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,17.3,20.6,14.6,"lymph node: 20.6 nTPM (protected, limit 2); cerebellum: 17.3 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 2); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000158987,RAPGEF6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.50303,-0.605802,-0.584502
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.6410% (minimum 95%, Missing); adrenal gland: 70.6587% (minimum 99%, Missing); amygdala: 76.6234% (minimum 99%, Missing); basal ganglia: 77.1242% (minimum 99%, Missing); bone marrow: 48.7603% (minimum 99%, Missing); cerebellum: 40.5498% (minimum 99%, Missing); cerebral cortex: 65.5556% (minimum 99%, Missing); choroid plexus: 86.7647% (minimum 99%, Missing); colon: 71.0843% (minimum 97%, Missing); duodenum: 76.1290% (minimum 99%, Missing); esophagus: 75.1592% (minimum 97%, Missing); heart muscle: 79.7297% (minimum 99%, Missing); hippocampal formation: 74.2138% (minimum 99%, Missing); hypothalamus: 71.9512% (minimum 99%, Missing); kidney: 74.6835% (minimum 99%, Missing); liver: 65.1934% (minimum 99%, Missing); lung: 63.7838% (minimum 99%, Missing); lymph node: 36.4198% (minimum 97%, Missing); midbrain: 74.2138% (minimum 99%, Missing); pancreas: 74.2138% (minimum 99%, Missing); parathyroid gland: 64.4809% (minimum 97%, Missing); pituitary gland: 80.8219% (minimum 99%, Missing); rectum: 68.6047% (minimum 97%, Missing); retina: 59.8985% (minimum 99%, Missing); salivary gland: 75.1592% (minimum 97%, Missing); skeletal muscle: 77.6316% (minimum 99%, Missing); skin: 72.3926% (minimum 95%, Missing); small intestine: 74.6835% (minimum 99%, Missing); smooth muscle: 75.1592% (minimum 99%, Missing); spinal cord: 69.8225% (minimum 99%, Missing); spleen: 57.8431% (minimum 95%, Missing); stomach: 71.9512% (minimum 97%, Missing); thymus: 44.6970% (minimum 95%, Missing); thyroid gland: 71.0843% (minimum 95%, Missing); tongue: 78.1457% (minimum 97%, Missing); urinary bladder: 68.6047% (minimum 97%, Missing)",0,2,partial,17.3,20.6,14.6,"lymph node: 20.6 nTPM (protected, limit 2); cerebellum: 17.3 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 2); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); hypothalamus: 4.6 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000158987,RAPGEF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.50303,-0.605802,-0.584502
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,67.7,29.8,32.5,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 6); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (manageable, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 12); stomach: 28.4 nTPM (protected, limit 2); liver: 28.3 nTPM (vital, limit 6); adrenal gland: 28.2 nTPM (vital, limit 1); salivary gland: 27.9 nTPM (protected, limit 2); spinal cord: 27.5 nTPM (vital, limit 1); skin: 26.9 nTPM (manageable, limit 5); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 6); colon: 25.6 nTPM (protected, limit 2); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 2); adipose tissue: 22.6 nTPM (manageable, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 12); lymph node: 16.1 nTPM (protected, limit 2); thymus: 15.6 nTPM (manageable, limit 5); bone marrow: 13.9 nTPM (vital, limit 6); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 2); tongue: 11.3 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000159079,CFAP298,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.7711% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.1716% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.5789% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.5299% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.2921% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.2608% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.9153% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 47.1507% (minimum 99%, Baseline (adaptation disabled)); colon: 70.2326% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.6216% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.9623% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.9884% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.5698% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.0769% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.2039% (minimum 99%, Baseline (adaptation disabled)); liver: 68.0947% (minimum 99%, Baseline (adaptation disabled)); lung: 71.3105% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.9542% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.8882% (minimum 99%, Baseline (adaptation disabled)); pancreas: 63.1799% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 74.6601% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.9778% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.9539% (minimum 97%, Baseline (adaptation disabled)); retina: 69.2661% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.4032% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.9831% (minimum 99%, Baseline (adaptation disabled)); skin: 69.1867% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.0351% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.5938% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.7144% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.3353% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.0180% (minimum 97%, Baseline (adaptation disabled)); thymus: 79.4737% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.0161% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.2399% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.6489% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,67.7,29.8,32.5,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 1); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (manageable, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 2); stomach: 28.4 nTPM (protected, limit 2); liver: 28.3 nTPM (vital, limit 1); adrenal gland: 28.2 nTPM (vital, limit 1); salivary gland: 27.9 nTPM (protected, limit 2); spinal cord: 27.5 nTPM (vital, limit 1); skin: 26.9 nTPM (manageable, limit 5); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 1); colon: 25.6 nTPM (protected, limit 2); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 2); spleen: 23.1 nTPM (manageable, limit 5); adipose tissue: 22.6 nTPM (manageable, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 2); lymph node: 16.1 nTPM (protected, limit 2); thymus: 15.6 nTPM (manageable, limit 5); bone marrow: 13.9 nTPM (vital, limit 1); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 2); tongue: 11.3 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000159079,CFAP298,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.299839,-0.300377,-0.518493
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.7711% (minimum 95%, Missing); adrenal gland: 68.1716% (minimum 99%, Missing); amygdala: 63.5789% (minimum 99%, Missing); basal ganglia: 64.5299% (minimum 99%, Missing); bone marrow: 81.2921% (minimum 95%, Enhanced); cerebellum: 55.2608% (minimum 99%, Missing); cerebral cortex: 63.9153% (minimum 99%, Missing); choroid plexus: 47.1507% (minimum 99%, Missing); colon: 70.2326% (minimum 97%, Missing); duodenum: 81.6216% (minimum 99%, Missing); esophagus: 66.9623% (minimum 80%, Enhanced); heart muscle: 69.9884% (minimum 95%, Enhanced); hippocampal formation: 61.5698% (minimum 99%, Missing); hypothalamus: 58.0769% (minimum 99%, Missing); kidney: 62.2039% (minimum 99%, Missing); liver: 68.0947% (minimum 95%, Enhanced); lung: 71.3105% (minimum 99%, Missing); lymph node: 78.9542% (minimum 97%, Missing); midbrain: 66.8882% (minimum 99%, Missing); pancreas: 63.1799% (minimum 99%, Missing); parathyroid gland: 74.6601% (minimum 80%, Enhanced); pituitary gland: 55.9778% (minimum 99%, Missing); rectum: 81.9539% (minimum 97%, Missing); retina: 69.2661% (minimum 99%, Missing); salivary gland: 68.4032% (minimum 97%, Missing); skeletal muscle: 63.9831% (minimum 95%, Enhanced); skin: 69.1867% (minimum 95%, Missing); small intestine: 73.0351% (minimum 99%, Missing); smooth muscle: 84.5938% (minimum 99%, Missing); spinal cord: 68.7144% (minimum 99%, Missing); stomach: 68.0180% (minimum 97%, Missing); thymus: 79.4737% (minimum 95%, Missing); thyroid gland: 65.0161% (minimum 95%, Missing); tongue: 84.2399% (minimum 97%, Missing); urinary bladder: 71.6489% (minimum 97%, Missing)",0,5,partial,67.7,29.8,32.5,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 6); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (manageable, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 12); stomach: 28.4 nTPM (protected, limit 2); liver: 28.3 nTPM (vital, limit 6); adrenal gland: 28.2 nTPM (vital, limit 1); salivary gland: 27.9 nTPM (protected, limit 2); spinal cord: 27.5 nTPM (vital, limit 1); skin: 26.9 nTPM (manageable, limit 5); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 6); colon: 25.6 nTPM (protected, limit 2); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 2); adipose tissue: 22.6 nTPM (manageable, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 12); lymph node: 16.1 nTPM (protected, limit 2); thymus: 15.6 nTPM (manageable, limit 5); bone marrow: 13.9 nTPM (vital, limit 6); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 2); tongue: 11.3 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000159079,CFAP298,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.299839,-0.28982,-0.518493
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,46.9,8.1,7.7,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 6); tongue: 6.2 nTPM (protected, limit 2); small intestine: 6.1 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); colon: 5.5 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); rectum: 5.3 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); pancreas: 4.7 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000159082,SYNJ1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.2254% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 34.7368% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 29.5522% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 29.6407% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 25.8486% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 19.3738% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 52.1053% (minimum 99%, Baseline (adaptation disabled)); colon: 64.2857% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.2628% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.2308% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.4907% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 28.2051% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 27.8090% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.2353% (minimum 99%, Baseline (adaptation disabled)); liver: 64.2857% (minimum 99%, Baseline (adaptation disabled)); lung: 55.9322% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.8750% (minimum 97%, Baseline (adaptation disabled)); midbrain: 31.4286% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.8082% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 42.4893% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.1316% (minimum 97%, Baseline (adaptation disabled)); retina: 17.4296% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.2759% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 57.2254% (minimum 99%, Baseline (adaptation disabled)); skin: 66.4430% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.8750% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.3469% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 47.1429% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.2500% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.3469% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.9286% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.2353% (minimum 95%, Baseline (adaptation disabled)); tongue: 61.4907% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.7059% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,46.9,8.1,7.7,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 2); lung: 7.8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); small intestine: 6.1 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); liver: 5.5 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); rectum: 5.3 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); esophagus: 4.4 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000159082,SYNJ1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.3875,-0.42,-0.815704
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.2254% (minimum 60%, Enhanced); adrenal gland: 60.0000% (minimum 99%, Missing); amygdala: 34.7368% (minimum 99%, Missing); basal ganglia: 29.5522% (minimum 99%, Missing); bone marrow: 29.6407% (minimum 99%, Missing); cerebellum: 25.8486% (minimum 99%, Missing); cerebral cortex: 19.3738% (minimum 99%, Missing); choroid plexus: 52.1053% (minimum 99%, Missing); colon: 64.2857% (minimum 97%, Missing); duodenum: 72.2628% (minimum 99%, Missing); esophagus: 69.2308% (minimum 80%, Enhanced); heart muscle: 61.4907% (minimum 95%, Enhanced); hippocampal formation: 28.2051% (minimum 99%, Missing); hypothalamus: 27.8090% (minimum 99%, Missing); kidney: 58.2353% (minimum 99%, Missing); liver: 64.2857% (minimum 95%, Enhanced); lung: 55.9322% (minimum 99%, Missing); lymph node: 61.8750% (minimum 97%, Missing); midbrain: 31.4286% (minimum 99%, Missing); pancreas: 67.8082% (minimum 99%, Missing); parathyroid gland: 55.0000% (minimum 80%, Enhanced); pituitary gland: 42.4893% (minimum 99%, Missing); rectum: 65.1316% (minimum 97%, Missing); retina: 17.4296% (minimum 99%, Missing); salivary gland: 68.2759% (minimum 80%, Enhanced); skeletal muscle: 57.2254% (minimum 99%, Missing); small intestine: 61.8750% (minimum 99%, Missing); smooth muscle: 67.3469% (minimum 99%, Missing); spinal cord: 47.1429% (minimum 99%, Missing); spleen: 56.2500% (minimum 95%, Missing); stomach: 67.3469% (minimum 97%, Missing); thymus: 58.9286% (minimum 95%, Missing); thyroid gland: 58.2353% (minimum 95%, Missing); tongue: 61.4907% (minimum 97%, Missing); urinary bladder: 64.7059% (minimum 97%, Missing)",0,6,partial,46.9,8.1,7.7,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 6); tongue: 6.2 nTPM (protected, limit 2); small intestine: 6.1 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); colon: 5.5 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); rectum: 5.3 nTPM (protected, limit 2); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); pancreas: 4.7 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000159082,SYNJ1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.3875,-0.355093,-0.815704
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,28.7,31,33.5,"thymus: 33.5 nTPM (manageable, limit 5); urinary bladder: 31 nTPM (protected, limit 2); lymph node: 29.5 nTPM (protected, limit 2); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 2); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 2); adipose tissue: 23.3 nTPM (manageable, limit 5); colon: 22.4 nTPM (protected, limit 2); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 2); thyroid gland: 20.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 2); adrenal gland: 19.6 nTPM (vital, limit 1); spleen: 19.5 nTPM (manageable, limit 5); parathyroid gland: 19.2 nTPM (protected, limit 2); stomach: 19.2 nTPM (protected, limit 2); small intestine: 18.8 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); salivary gland: 16.3 nTPM (protected, limit 2); lung: 15.5 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000159131,GART,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0193% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 59.2516% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.4286% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.5122% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.6383% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.2648% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.6383% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.7041% (minimum 99%, Baseline (adaptation disabled)); colon: 55.9921% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.1825% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.7629% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.8342% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.4286% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.5216% (minimum 99%, Baseline (adaptation disabled)); liver: 49.8252% (minimum 99%, Baseline (adaptation disabled)); lung: 64.7727% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.1379% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.3431% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.7729% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.7484% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.6822% (minimum 99%, Baseline (adaptation disabled)); rectum: 50.3534% (minimum 97%, Baseline (adaptation disabled)); retina: 58.6420% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.6161% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.4425% (minimum 99%, Baseline (adaptation disabled)); skin: 62.9139% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.2537% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 52.9740% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.1818% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.3750% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.7484% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.9677% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.5216% (minimum 95%, Baseline (adaptation disabled)); tongue: 57.6923% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 47.8992% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,28.7,31,33.5,"thymus: 33.5 nTPM (manageable, limit 5); urinary bladder: 31 nTPM (protected, limit 2); lymph node: 29.5 nTPM (protected, limit 2); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 2); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 2); adipose tissue: 23.3 nTPM (manageable, limit 5); colon: 22.4 nTPM (protected, limit 2); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 2); thyroid gland: 20.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); adrenal gland: 19.6 nTPM (vital, limit 1); spleen: 19.5 nTPM (manageable, limit 5); parathyroid gland: 19.2 nTPM (protected, limit 2); stomach: 19.2 nTPM (protected, limit 2); small intestine: 18.8 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); salivary gland: 16.3 nTPM (protected, limit 2); lung: 15.5 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000159131,GART,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.490323,-0.491008,-0.491748
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0193% (minimum 95%, Missing); adrenal gland: 59.2516% (minimum 99%, Missing); amygdala: 71.4286% (minimum 99%, Missing); basal ganglia: 69.5122% (minimum 99%, Missing); bone marrow: 60.6383% (minimum 99%, Missing); cerebellum: 73.2648% (minimum 99%, Missing); cerebral cortex: 60.6383% (minimum 99%, Missing); choroid plexus: 72.7041% (minimum 99%, Missing); colon: 55.9921% (minimum 97%, Missing); duodenum: 57.0000% (minimum 99%, Missing); esophagus: 54.1825% (minimum 97%, Missing); heart muscle: 58.7629% (minimum 98%, Approved); hippocampal formation: 73.8342% (minimum 99%, Missing); hypothalamus: 71.4286% (minimum 99%, Missing); kidney: 58.5216% (minimum 99%, Missing); liver: 49.8252% (minimum 99%, Missing); lung: 64.7727% (minimum 99%, Missing); lymph node: 49.1379% (minimum 97%, Missing); midbrain: 69.3431% (minimum 99%, Missing); pancreas: 56.7729% (minimum 99%, Missing); parathyroid gland: 59.7484% (minimum 97%, Missing); pituitary gland: 69.6822% (minimum 99%, Missing); rectum: 50.3534% (minimum 97%, Missing); retina: 58.6420% (minimum 99%, Missing); salivary gland: 63.6161% (minimum 97%, Missing); skeletal muscle: 50.4425% (minimum 99%, Missing); skin: 62.9139% (minimum 95%, Missing); small intestine: 60.2537% (minimum 99%, Missing); smooth muscle: 52.9740% (minimum 99%, Missing); spinal cord: 68.1818% (minimum 99%, Missing); spleen: 59.3750% (minimum 95%, Missing); stomach: 59.7484% (minimum 97%, Missing); thymus: 45.9677% (minimum 95%, Missing); thyroid gland: 58.5216% (minimum 95%, Missing); tongue: 57.6923% (minimum 97%, Missing); urinary bladder: 47.8992% (minimum 97%, Missing)",0,1,partial,28.7,31,33.5,"thymus: 33.5 nTPM (manageable, limit 5); urinary bladder: 31 nTPM (protected, limit 2); lymph node: 29.5 nTPM (protected, limit 2); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 2); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 2); adipose tissue: 23.3 nTPM (manageable, limit 5); colon: 22.4 nTPM (protected, limit 2); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 2); thyroid gland: 20.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 2); adrenal gland: 19.6 nTPM (vital, limit 1); spleen: 19.5 nTPM (manageable, limit 5); parathyroid gland: 19.2 nTPM (protected, limit 2); stomach: 19.2 nTPM (protected, limit 2); small intestine: 18.8 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); salivary gland: 16.3 nTPM (protected, limit 2); lung: 15.5 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000159131,GART,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.490323,-0.491008,-0.491748
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,1.2,0.3,0,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,ENSG00000159217,IGF2BP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 81.5385% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1481% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.6429% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.1481% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,1.2,0.3,0,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,ENSG00000159217,IGF2BP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,0.05,-0.0235714,-0.174615
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 81.5385% (minimum 99%, Missing); lymph node: 94.6429% (minimum 97%, Missing)",0,4,partial,1.2,0.3,0,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,ENSG00000159217,IGF2BP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,0.05,-0.0235714,-0.174615
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,10,partial,251.8,1.2,0.1,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),74,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000159224,GIP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 62.5000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 0.1982% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.3333% (minimum 97%, Baseline (adaptation disabled)); small intestine: 0.5453% (minimum 99%, Baseline (adaptation disabled)); stomach: 29.4118% (minimum 97%, Baseline (adaptation disabled)); thymus: 83.3333% (minimum 95%, Baseline (adaptation disabled))",0,10,partial,251.8,1.2,0.1,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),74,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000159224,GIP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.116667,-0.675882,-0.988018
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 83.3333% (minimum 95%, Enhanced); colon: 62.5000% (minimum 97%, Missing); duodenum: 0.1982% (minimum 99%, Missing); small intestine: 0.5453% (minimum 99%, Missing); stomach: 29.4118% (minimum 80%, Enhanced); thymus: 83.3333% (minimum 95%, Missing)",0,10,partial,251.8,1.2,0.1,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),74,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000159224,GIP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.116667,-0.505882,-0.988018
True,compatible,,True,True,False,,0,1,partial,2.2,0,0.1,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000159289,GOLGA6A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 86.9822% (minimum 99%, Baseline (adaptation disabled)); retina: 98.6577% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.6577% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,2.2,0,0.1,"liver: 2.2 nTPM (vital, limit 1)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000159289,GOLGA6A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0432432,0.03,-0.120178
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 86.9822% (minimum 97%, Supported); retina: 98.6577% (minimum 99%, Missing)",0,1,partial,2.2,0,0.1,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000159289,GOLGA6A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.100178
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.4,0.9,1.2,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000159374,M1AP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9231% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.3043% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.9231% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.4138% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.4375% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.3043% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.3043% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.4375% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.4545% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.3043% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.3014% (minimum 99%, Baseline (adaptation disabled)); lung: 96.9231% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.9231% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.4375% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.7324% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.7500% (minimum 99%, Baseline (adaptation disabled)); retina: 92.6471% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.5000% (minimum 97%, Baseline (adaptation disabled)); spinal cord: 96.9231% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.4545% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 84.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.9231% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.4,0.9,1.2,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000159374,M1AP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.11,-0.095,-0.265862
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9231% (minimum 99%, Missing); amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 96.9231% (minimum 99%, Missing); bone marrow: 72.4138% (minimum 99%, Missing); cerebellum: 98.4375% (minimum 99%, Missing); cerebral cortex: 91.3043% (minimum 99%, Missing); choroid plexus: 91.3043% (minimum 99%, Missing); duodenum: 98.4375% (minimum 99%, Missing); hippocampal formation: 95.4545% (minimum 99%, Missing); hypothalamus: 91.3043% (minimum 99%, Missing); kidney: 86.3014% (minimum 99%, Missing); lung: 96.9231% (minimum 99%, Missing); midbrain: 96.9231% (minimum 99%, Missing); pancreas: 98.4375% (minimum 99%, Missing); parathyroid gland: 88.7324% (minimum 97%, Missing); pituitary gland: 78.7500% (minimum 99%, Missing); retina: 92.6471% (minimum 99%, Missing); salivary gland: 87.5000% (minimum 97%, Missing); spinal cord: 96.9231% (minimum 99%, Missing); stomach: 95.4545% (minimum 97%, Missing); thyroid gland: 84.0000% (minimum 95%, Missing); urinary bladder: 96.9231% (minimum 97%, Missing)",0,80,unavailable,2.4,0.9,1.2,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000159374,M1AP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.11,-0.095,-0.265862
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.3,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000159495,TGM7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 72.7273% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000159495,TGM7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,-0.303333,-0.262727
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"esophagus: 66.6667% (minimum 97%, Missing); skeletal muscle: 72.7273% (minimum 99%, Missing)",0,80,unavailable,0.3,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000159495,TGM7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,-0.303333,-0.262727
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12,0.7,0.2,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000159625,DRC7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.5983% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.1064% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.8118% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.8938% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.8360% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.1290% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.5128% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2418% (minimum 99%, Baseline (adaptation disabled)); lung: 95.9227% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.6755% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.5983% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.8118% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8938% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,12,0.7,0.2,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000159625,DRC7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0455457,0.0145815,-0.20164
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.5983% (minimum 99%, Missing); basal ganglia: 95.1064% (minimum 99%, Missing); bone marrow: 97.8118% (minimum 99%, Missing); cerebral cortex: 98.8938% (minimum 99%, Missing); choroid plexus: 78.8360% (minimum 99%, Missing); hippocampal formation: 96.1290% (minimum 99%, Missing); hypothalamus: 95.5128% (minimum 99%, Missing); kidney: 98.2418% (minimum 99%, Missing); lung: 95.9227% (minimum 99%, Missing); midbrain: 98.6755% (minimum 99%, Missing); pancreas: 97.5983% (minimum 99%, Missing); pituitary gland: 97.8118% (minimum 99%, Missing); spinal cord: 98.8938% (minimum 99%, Missing)",0,80,unavailable,12,0.7,0.2,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000159625,DRC7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0455457,0.0145815,-0.20164
True,compatible,,True,True,False,,0,3,partial,4.8,0.5,0.1,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000159708,LRRC36,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 87.7238% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,4.8,0.5,0.1,"lung: 4.8 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000159708,LRRC36,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.047093,0.0156322,-0.112762
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lung: 87.7238% (minimum 95%, Enhanced)",0,3,partial,4.8,0.5,0.1,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000159708,LRRC36,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.05,0.03,-0.0727621
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,10,4,3.4,"cerebellum: 10 nTPM (vital, limit 6); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159761,C16orf86,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.9240% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.4783% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.1606% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.8451% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.4733% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.4661% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.3902% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.7615% (minimum 99%, Baseline (adaptation disabled)); colon: 90.6323% (minimum 97%, Baseline (adaptation disabled)); esophagus: 96.7500% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.5837% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.3902% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.7046% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.2098% (minimum 99%, Baseline (adaptation disabled)); liver: 94.8529% (minimum 99%, Baseline (adaptation disabled)); lung: 95.3202% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.5087% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.3628% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.3902% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.9320% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.3902% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4733% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0298% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.5833% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.5556% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7245% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.4783% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.3902% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.3202% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.9320% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.7046% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.3628% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,10,4,3.4,"cerebellum: 10 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); basal ganglia: 3.9 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); midbrain: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159761,C16orf86,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0307601,-0.0636768,-0.195339
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.4783% (minimum 95%, Enhanced); amygdala: 94.1606% (minimum 99%, Missing); basal ganglia: 90.8451% (minimum 99%, Missing); cerebellum: 79.4661% (minimum 95%, Enhanced); cerebral cortex: 94.3902% (minimum 95%, Enhanced); choroid plexus: 88.7615% (minimum 99%, Missing); heart muscle: 92.5837% (minimum 95%, Enhanced); hippocampal formation: 94.3902% (minimum 99%, Missing); hypothalamus: 93.7046% (minimum 99%, Missing); kidney: 90.2098% (minimum 95%, Enhanced); liver: 94.8529% (minimum 95%, Enhanced); midbrain: 92.3628% (minimum 99%, Missing); pancreas: 94.3902% (minimum 95%, Enhanced); pituitary gland: 94.3902% (minimum 99%, Missing); retina: 98.4733% (minimum 99%, Missing); skeletal muscle: 89.5833% (minimum 95%, Enhanced); spinal cord: 93.4783% (minimum 99%, Missing); tongue: 93.7046% (minimum 97%, Missing)",0,4,partial,10,4,3.4,"cerebellum: 10 nTPM (vital, limit 6); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159761,C16orf86,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00555556,-0.032954,-0.155339
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.5,3.3,3.9,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); lymph node: 3.3 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159882,ZNF230,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.1509% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.8182% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.9130% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.8333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 51.5152% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.5714% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.8333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 61.8182% (minimum 99%, Baseline (adaptation disabled)); colon: 64.1509% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.9130% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.8333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.3846% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.9130% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.3404% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 62.9630% (minimum 99%, Baseline (adaptation disabled)); lung: 59.6491% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.7463% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.9130% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.8333% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 56.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.1509% (minimum 97%, Baseline (adaptation disabled)); retina: 43.0380% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.3846% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.9524% (minimum 99%, Baseline (adaptation disabled)); skin: 54.8387% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.6491% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.3846% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.8333% (minimum 99%, Baseline (adaptation disabled)); spleen: 47.2222% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.3846% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.5753% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.9683% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.3846% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.9630% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.5,3.3,3.9,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); lymph node: 3.3 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159882,ZNF230,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.484247,-0.462537,-0.55962
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.1509% (minimum 95%, Missing); adrenal gland: 61.8182% (minimum 99%, Missing); amygdala: 73.9130% (minimum 99%, Missing); basal ganglia: 70.8333% (minimum 99%, Missing); bone marrow: 51.5152% (minimum 99%, Missing); cerebellum: 48.5714% (minimum 99%, Missing); cerebral cortex: 70.8333% (minimum 99%, Missing); choroid plexus: 61.8182% (minimum 99%, Missing); colon: 64.1509% (minimum 97%, Missing); duodenum: 73.9130% (minimum 99%, Missing); esophagus: 70.8333% (minimum 97%, Missing); heart muscle: 65.3846% (minimum 99%, Missing); hippocampal formation: 73.9130% (minimum 99%, Missing); hypothalamus: 72.3404% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 62.9630% (minimum 99%, Missing); lung: 59.6491% (minimum 99%, Missing); lymph node: 50.7463% (minimum 97%, Missing); midbrain: 73.9130% (minimum 99%, Missing); pancreas: 70.8333% (minimum 99%, Missing); parathyroid gland: 56.6667% (minimum 97%, Missing); pituitary gland: 56.6667% (minimum 99%, Missing); rectum: 64.1509% (minimum 97%, Missing); retina: 43.0380% (minimum 99%, Missing); salivary gland: 65.3846% (minimum 97%, Missing); skeletal muscle: 80.9524% (minimum 99%, Missing); skin: 54.8387% (minimum 95%, Missing); small intestine: 59.6491% (minimum 99%, Missing); smooth muscle: 65.3846% (minimum 99%, Missing); spinal cord: 70.8333% (minimum 99%, Missing); spleen: 47.2222% (minimum 95%, Missing); stomach: 65.3846% (minimum 97%, Missing); thymus: 46.5753% (minimum 95%, Missing); thyroid gland: 53.9683% (minimum 95%, Missing); tongue: 65.3846% (minimum 97%, Missing); urinary bladder: 62.9630% (minimum 97%, Missing)",0,80,unavailable,4.5,3.3,3.9,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); lymph node: 3.3 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159882,ZNF230,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.484247,-0.462537,-0.55962
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,2.2,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159905,ZNF221,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 65.2174% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.6923% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 37.5000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.1818% (minimum 99%, Baseline (adaptation disabled)); colon: 68.1818% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.2174% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 55.5556% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.1818% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 57.6923% (minimum 99%, Baseline (adaptation disabled)); lung: 62.5000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.4286% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.1818% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 40.5405% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.5000% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.2174% (minimum 97%, Baseline (adaptation disabled)); retina: 34.0909% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.1818% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 57.6923% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.1818% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.2174% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.2174% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.6923% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 46.8750% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.1818% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,2.2,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159905,ZNF221,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.48125,-0.564595,-0.649091
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 65.2174% (minimum 95%, Missing); adrenal gland: 57.6923% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 75.0000% (minimum 99%, Missing); cerebellum: 37.5000% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); choroid plexus: 68.1818% (minimum 99%, Missing); colon: 68.1818% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 65.2174% (minimum 97%, Missing); heart muscle: 55.5556% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 68.1818% (minimum 99%, Missing); kidney: 60.0000% (minimum 99%, Missing); liver: 57.6923% (minimum 99%, Missing); lung: 62.5000% (minimum 99%, Missing); lymph node: 71.4286% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 68.1818% (minimum 99%, Missing); parathyroid gland: 40.5405% (minimum 97%, Missing); pituitary gland: 62.5000% (minimum 99%, Missing); rectum: 65.2174% (minimum 97%, Missing); retina: 34.0909% (minimum 99%, Missing); salivary gland: 68.1818% (minimum 97%, Missing); skeletal muscle: 83.3333% (minimum 99%, Missing); skin: 57.6923% (minimum 95%, Missing); small intestine: 68.1818% (minimum 99%, Missing); smooth muscle: 53.5714% (minimum 99%, Missing); spinal cord: 65.2174% (minimum 99%, Missing); spleen: 60.0000% (minimum 95%, Missing); stomach: 65.2174% (minimum 97%, Missing); thymus: 57.6923% (minimum 95%, Missing); thyroid gland: 46.8750% (minimum 95%, Missing); tongue: 68.1818% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",0,80,unavailable,2.9,2.2,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159905,ZNF221,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.48125,-0.564595,-0.649091
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.7,2.9,1.9,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159915,ZNF233,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.4211% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.6543% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.0606% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.3082% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.1739% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.0809% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.4459% (minimum 99%, Baseline (adaptation disabled)); colon: 83.0409% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.0397% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.9459% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.5581% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.0606% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.0237% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.2078% (minimum 99%, Baseline (adaptation disabled)); liver: 96.5986% (minimum 99%, Baseline (adaptation disabled)); lung: 96.5986% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.6129% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.3082% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.3082% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.5581% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.2078% (minimum 97%, Baseline (adaptation disabled)); retina: 75.1323% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.4459% (minimum 99%, Baseline (adaptation disabled)); skin: 90.4459% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.0397% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.2603% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.1988% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.6129% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.8105% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.0256% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.1988% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.9459% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.6667% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.7,2.9,1.9,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159915,ZNF233,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0680124,-0.139591,-0.238677
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.4211% (minimum 99%, Missing); amygdala: 87.6543% (minimum 99%, Missing); basal ganglia: 86.0606% (minimum 99%, Missing); bone marrow: 89.3082% (minimum 99%, Missing); cerebellum: 77.1739% (minimum 99%, Missing); cerebral cortex: 82.0809% (minimum 99%, Missing); choroid plexus: 90.4459% (minimum 99%, Missing); colon: 83.0409% (minimum 97%, Missing); duodenum: 94.0397% (minimum 99%, Missing); esophagus: 95.9459% (minimum 97%, Missing); heart muscle: 82.5581% (minimum 99%, Missing); hippocampal formation: 86.0606% (minimum 99%, Missing); hypothalamus: 84.0237% (minimum 99%, Missing); kidney: 92.2078% (minimum 99%, Missing); liver: 96.5986% (minimum 99%, Missing); lung: 96.5986% (minimum 99%, Missing); lymph node: 91.6129% (minimum 97%, Missing); midbrain: 89.3082% (minimum 99%, Missing); pancreas: 94.6667% (minimum 99%, Missing); parathyroid gland: 89.3082% (minimum 97%, Missing); pituitary gland: 82.5581% (minimum 99%, Missing); rectum: 92.2078% (minimum 97%, Missing); retina: 75.1323% (minimum 99%, Missing); salivary gland: 94.6667% (minimum 97%, Missing); skeletal muscle: 90.4459% (minimum 99%, Missing); skin: 90.4459% (minimum 95%, Missing); small intestine: 94.0397% (minimum 99%, Missing); smooth muscle: 97.2603% (minimum 99%, Missing); spinal cord: 88.1988% (minimum 99%, Missing); spleen: 91.6129% (minimum 95%, Missing); stomach: 92.8105% (minimum 97%, Missing); thymus: 91.0256% (minimum 95%, Missing); thyroid gland: 88.1988% (minimum 95%, Missing); tongue: 95.9459% (minimum 97%, Missing); urinary bladder: 94.6667% (minimum 97%, Missing)",0,80,unavailable,4.7,2.9,1.9,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000159915,ZNF233,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0680124,-0.139591,-0.238677
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,4.9,5.9,5.3,"tongue: 5.9 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); cerebellum: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000160062,ZBTB8A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.8557% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.1707% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.0811% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.1918% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.5070% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.9341% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.1707% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.5522% (minimum 99%, Baseline (adaptation disabled)); colon: 68.1818% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.9231% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.5161% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.2892% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.1918% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.5070% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.2892% (minimum 99%, Baseline (adaptation disabled)); liver: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 68.9655% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.2353% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.7143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.7674% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.1579% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.9231% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.4157% (minimum 97%, Baseline (adaptation disabled)); retina: 81.0811% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.4286% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.7674% (minimum 99%, Baseline (adaptation disabled)); skin: 77.9221% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.0459% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.9474% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.9341% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.1918% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.0973% (minimum 95%, Baseline (adaptation disabled)); tongue: 50.4202% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.5000% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,4.9,5.9,5.3,"tongue: 5.9 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); cerebellum: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000160062,ZBTB8A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.419027,-0.465798,-0.439541
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.8557% (minimum 95%, Missing); adrenal gland: 73.1707% (minimum 99%, Missing); amygdala: 81.0811% (minimum 99%, Missing); basal ganglia: 82.1918% (minimum 99%, Missing); bone marrow: 84.5070% (minimum 99%, Missing); cerebellum: 65.9341% (minimum 99%, Missing); cerebral cortex: 73.1707% (minimum 99%, Missing); choroid plexus: 89.5522% (minimum 99%, Missing); colon: 68.1818% (minimum 97%, Missing); duodenum: 76.9231% (minimum 99%, Missing); esophagus: 64.5161% (minimum 97%, Missing); heart muscle: 72.2892% (minimum 99%, Missing); hippocampal formation: 82.1918% (minimum 99%, Missing); hypothalamus: 84.5070% (minimum 99%, Missing); kidney: 72.2892% (minimum 99%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 68.9655% (minimum 99%, Missing); lymph node: 88.2353% (minimum 97%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 69.7674% (minimum 99%, Missing); parathyroid gland: 63.1579% (minimum 97%, Missing); pituitary gland: 76.9231% (minimum 99%, Missing); rectum: 67.4157% (minimum 97%, Missing); retina: 81.0811% (minimum 99%, Missing); salivary gland: 71.4286% (minimum 97%, Missing); skeletal muscle: 69.7674% (minimum 99%, Missing); skin: 77.9221% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 55.0459% (minimum 99%, Missing); spinal cord: 78.9474% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 65.9341% (minimum 97%, Missing); thymus: 82.1918% (minimum 95%, Missing); thyroid gland: 53.0973% (minimum 95%, Missing); tongue: 50.4202% (minimum 97%, Missing); urinary bladder: 62.5000% (minimum 97%, Missing)",0,2,partial,4.9,5.9,5.3,"tongue: 5.9 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); cerebellum: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); colon: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000160062,ZBTB8A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.419027,-0.465798,-0.439541
True,compatible,,True,True,False,,0,80,unavailable,1,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000160161,CILP2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 88.5246% (minimum 95%, Baseline (adaptation disabled)); amygdala: 94.7368% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.7368% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.3750% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1818% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.1034% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 93.1034% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.7368% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.5254% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.4286% (minimum 99%, Baseline (adaptation disabled)); liver: 96.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 93.1034% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.7368% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.7368% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 94.7368% (minimum 99%, Baseline (adaptation disabled)); skin: 94.7368% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.1818% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.1818% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 85.7143% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.7368% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000160161,CILP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0928571,-0.0226316,-0.14625
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 88.5246% (minimum 95%, Missing); amygdala: 94.7368% (minimum 99%, Missing); basal ganglia: 94.7368% (minimum 99%, Missing); bone marrow: 84.3750% (minimum 99%, Missing); cerebellum: 98.1818% (minimum 99%, Missing); cerebral cortex: 93.1034% (minimum 99%, Missing); heart muscle: 93.1034% (minimum 99%, Missing); hippocampal formation: 94.7368% (minimum 99%, Missing); hypothalamus: 91.5254% (minimum 99%, Missing); kidney: 96.4286% (minimum 99%, Missing); liver: 96.4286% (minimum 99%, Missing); lung: 93.1034% (minimum 99%, Missing); lymph node: 94.7368% (minimum 97%, Missing); pituitary gland: 94.7368% (minimum 99%, Missing); skeletal muscle: 94.7368% (minimum 99%, Missing); skin: 94.7368% (minimum 95%, Missing); small intestine: 98.1818% (minimum 99%, Missing); smooth muscle: 98.1818% (minimum 99%, Missing); thyroid gland: 85.7143% (minimum 95%, Missing); urinary bladder: 94.7368% (minimum 97%, Missing)",0,80,unavailable,1,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000160161,CILP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0928571,-0.0226316,-0.14625
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,2.4,0.7,0.5,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160207,HSF2BP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.7342% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.2963% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.0954% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.6977% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.9079% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.7342% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.6942% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.2963% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.9079% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.1220% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.6942% (minimum 99%, Baseline (adaptation disabled)); retina: 96.2963% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.1220% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,2.4,0.7,0.5,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160207,HSF2BP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0290795,0.000954357,-0.0830233
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.2963% (minimum 99%, Missing); basal ganglia: 97.0954% (minimum 99%, Missing); cerebral cortex: 90.6977% (minimum 99%, Missing); choroid plexus: 97.9079% (minimum 99%, Missing); hippocampal formation: 96.6942% (minimum 99%, Missing); hypothalamus: 96.2963% (minimum 99%, Missing); midbrain: 95.1220% (minimum 99%, Missing); pituitary gland: 96.6942% (minimum 99%, Missing); retina: 96.2963% (minimum 99%, Missing); spinal cord: 95.1220% (minimum 99%, Missing)",0,4,partial,2.4,0.7,0.5,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160207,HSF2BP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0457447,0.0257447,-0.0830233
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.5,4.7,6.4,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.4 nTPM (manageable, limit 5); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); tongue: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160318,CLDND2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.1031% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.8524% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.8211% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.8211% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.1429% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.9177% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.5752% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.6863% (minimum 99%, Baseline (adaptation disabled)); colon: 90.6639% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.8524% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.3844% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.1770% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.2828% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.1048% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.2317% (minimum 99%, Baseline (adaptation disabled)); liver: 90.4762% (minimum 99%, Baseline (adaptation disabled)); lung: 93.3761% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.8333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.8787% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.5492% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.9787% (minimum 99%, Baseline (adaptation disabled)); retina: 96.0440% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.2317% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.7939% (minimum 99%, Baseline (adaptation disabled)); small intestine: 91.2317% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6456% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.2255% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.9785% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.7813% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.5887% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.2893% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.5,4.7,6.4,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.4 nTPM (manageable, limit 5); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); tongue: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160318,CLDND2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0777445,-0.0671074,-0.168571
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.1031% (minimum 95%, Missing); adrenal gland: 90.8524% (minimum 99%, Missing); amygdala: 88.8211% (minimum 99%, Missing); basal ganglia: 88.8211% (minimum 99%, Missing); bone marrow: 82.1429% (minimum 99%, Missing); cerebellum: 89.9177% (minimum 99%, Missing); cerebral cortex: 87.5752% (minimum 99%, Missing); choroid plexus: 85.6863% (minimum 99%, Missing); colon: 90.6639% (minimum 97%, Missing); duodenum: 90.8524% (minimum 99%, Missing); esophagus: 94.3844% (minimum 97%, Missing); heart muscle: 93.1770% (minimum 99%, Missing); hippocampal formation: 88.2828% (minimum 99%, Missing); hypothalamus: 88.1048% (minimum 99%, Missing); kidney: 91.2317% (minimum 99%, Missing); liver: 90.4762% (minimum 99%, Missing); lung: 93.3761% (minimum 99%, Missing); lymph node: 95.8333% (minimum 97%, Missing); midbrain: 86.8787% (minimum 99%, Missing); pancreas: 89.5492% (minimum 99%, Missing); pituitary gland: 92.9787% (minimum 99%, Missing); retina: 96.0440% (minimum 99%, Missing); salivary gland: 91.2317% (minimum 97%, Missing); skeletal muscle: 94.7939% (minimum 99%, Missing); small intestine: 91.2317% (minimum 99%, Missing); smooth muscle: 98.6456% (minimum 99%, Missing); spinal cord: 92.0000% (minimum 99%, Missing); spleen: 87.2255% (minimum 95%, Missing); stomach: 93.9785% (minimum 97%, Missing); thyroid gland: 92.7813% (minimum 95%, Missing); tongue: 94.5887% (minimum 97%, Missing); urinary bladder: 90.2893% (minimum 97%, Missing)",0,80,unavailable,9.5,4.7,6.4,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.4 nTPM (manageable, limit 5); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); tongue: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160318,CLDND2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0777445,-0.0671074,-0.168571
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.9,12.8,7.5,"parathyroid gland: 12.8 nTPM (protected, limit 2); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); spinal cord: 4.4 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160321,ZNF208,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.2131% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.1720% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.8462% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.3585% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 86.3158% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.1111% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.5455% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.6735% (minimum 99%, Baseline (adaptation disabled)); colon: 63.5659% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.3158% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.8462% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 42.9319% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.2131% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 48.5207% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.0794% (minimum 99%, Baseline (adaptation disabled)); liver: 93.1818% (minimum 99%, Baseline (adaptation disabled)); lung: 86.3158% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.9259% (minimum 97%, Baseline (adaptation disabled)); midbrain: 50.6173% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.6117% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 39.0476% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 54.3046% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.4167% (minimum 97%, Baseline (adaptation disabled)); retina: 78.0952% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.9259% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.1099% (minimum 99%, Baseline (adaptation disabled)); skin: 68.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.6117% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.0794% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.6355% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.6735% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.2529% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.2293% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.3158% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.5664% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.9,12.8,7.5,"parathyroid gland: 12.8 nTPM (protected, limit 2); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); spinal cord: 4.4 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160321,ZNF208,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.427707,-0.579524,-0.560681
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.2131% (minimum 95%, Missing); adrenal gland: 88.1720% (minimum 99%, Missing); amygdala: 78.8462% (minimum 99%, Missing); basal ganglia: 77.3585% (minimum 99%, Missing); bone marrow: 86.3158% (minimum 99%, Missing); cerebellum: 91.1111% (minimum 99%, Missing); cerebral cortex: 74.5455% (minimum 99%, Missing); choroid plexus: 83.6735% (minimum 99%, Missing); colon: 63.5659% (minimum 97%, Missing); duodenum: 86.3158% (minimum 99%, Missing); esophagus: 78.8462% (minimum 97%, Missing); heart muscle: 42.9319% (minimum 99%, Missing); hippocampal formation: 67.2131% (minimum 99%, Missing); hypothalamus: 48.5207% (minimum 99%, Missing); kidney: 65.0794% (minimum 99%, Missing); liver: 93.1818% (minimum 99%, Missing); lung: 86.3158% (minimum 99%, Missing); lymph node: 75.9259% (minimum 97%, Missing); midbrain: 50.6173% (minimum 99%, Missing); pancreas: 79.6117% (minimum 99%, Missing); parathyroid gland: 39.0476% (minimum 97%, Missing); pituitary gland: 54.3046% (minimum 99%, Missing); rectum: 85.4167% (minimum 97%, Missing); retina: 78.0952% (minimum 99%, Missing); salivary gland: 75.9259% (minimum 97%, Missing); skeletal muscle: 90.1099% (minimum 99%, Missing); skin: 68.3333% (minimum 95%, Missing); small intestine: 79.6117% (minimum 99%, Missing); smooth muscle: 58.5714% (minimum 99%, Missing); spinal cord: 65.0794% (minimum 99%, Missing); spleen: 76.6355% (minimum 95%, Missing); stomach: 83.6735% (minimum 97%, Missing); thymus: 94.2529% (minimum 95%, Missing); thyroid gland: 52.2293% (minimum 95%, Missing); tongue: 86.3158% (minimum 97%, Missing); urinary bladder: 72.5664% (minimum 97%, Missing)",0,80,unavailable,10.9,12.8,7.5,"parathyroid gland: 12.8 nTPM (protected, limit 2); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 2); spinal cord: 4.4 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160321,ZNF208,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.427707,-0.579524,-0.560681
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.8,5.1,13.9,"thyroid gland: 13.9 nTPM (manageable, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); skin: 6.4 nTPM (manageable, limit 5); cerebellum: 6.3 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 2); lymph node: 4.7 nTPM (protected, limit 2); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160352,ZNF714,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.5063% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.8817% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.3750% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.1839% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 67.7725% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 69.4175% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 87.1951% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.6287% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.7113% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.0828% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.8199% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.7301% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.9371% (minimum 99%, Baseline (adaptation disabled)); liver: 95.9732% (minimum 99%, Baseline (adaptation disabled)); lung: 87.7301% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.2632% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.3750% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.4444% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.5063% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.2581% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.3371% (minimum 97%, Baseline (adaptation disabled)); retina: 82.1839% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.7301% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.1176% (minimum 99%, Baseline (adaptation disabled)); skin: 69.0821% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.9371% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.8199% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.1446% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.1176% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.2222% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.7092% (minimum 95%, Baseline (adaptation disabled)); tongue: 89.3750% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.9371% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.8,5.1,13.9,"thyroid gland: 13.9 nTPM (manageable, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); skin: 6.4 nTPM (manageable, limit 5); cerebellum: 6.3 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 2); lymph node: 4.7 nTPM (protected, limit 2); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160352,ZNF714,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.442908,-0.232887,-0.312275
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.5063% (minimum 95%, Missing); adrenal gland: 76.8817% (minimum 99%, Missing); amygdala: 89.3750% (minimum 99%, Missing); basal ganglia: 82.1839% (minimum 99%, Missing); bone marrow: 67.7725% (minimum 99%, Missing); cerebellum: 69.4175% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 99%, Missing); choroid plexus: 95.3333% (minimum 99%, Missing); colon: 87.1951% (minimum 97%, Missing); duodenum: 85.6287% (minimum 99%, Missing); esophagus: 73.7113% (minimum 97%, Missing); heart muscle: 91.0828% (minimum 99%, Missing); hippocampal formation: 88.8199% (minimum 99%, Missing); hypothalamus: 87.7301% (minimum 99%, Missing); kidney: 89.9371% (minimum 99%, Missing); liver: 95.9732% (minimum 99%, Missing); lung: 87.7301% (minimum 99%, Missing); lymph node: 75.2632% (minimum 97%, Missing); midbrain: 89.3750% (minimum 99%, Missing); pancreas: 79.4444% (minimum 99%, Missing); parathyroid gland: 90.5063% (minimum 97%, Missing); pituitary gland: 92.2581% (minimum 99%, Missing); rectum: 80.3371% (minimum 97%, Missing); retina: 82.1839% (minimum 99%, Missing); salivary gland: 87.7301% (minimum 97%, Missing); skeletal muscle: 84.1176% (minimum 99%, Missing); skin: 69.0821% (minimum 95%, Missing); small intestine: 81.7143% (minimum 99%, Missing); smooth muscle: 89.9371% (minimum 99%, Missing); spinal cord: 88.8199% (minimum 99%, Missing); spleen: 86.1446% (minimum 95%, Missing); stomach: 84.1176% (minimum 97%, Missing); thymus: 72.2222% (minimum 95%, Missing); thyroid gland: 50.7092% (minimum 95%, Missing); tongue: 89.3750% (minimum 97%, Missing); urinary bladder: 89.9371% (minimum 97%, Missing)",0,80,unavailable,6.8,5.1,13.9,"thyroid gland: 13.9 nTPM (manageable, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); skin: 6.4 nTPM (manageable, limit 5); cerebellum: 6.3 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 2); lymph node: 4.7 nTPM (protected, limit 2); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160352,ZNF714,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.442908,-0.232887,-0.312275
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.8,0.5,0.2,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000160396,HIPK4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 85.8537% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.7216% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.2222% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.3240% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.1060% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1749% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8764% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.6522% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8764% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,8.8,0.5,0.2,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000160396,HIPK4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.038764,0.00237569,-0.323333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 85.8537% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); cerebellum: 90.7216% (minimum 99%, Missing); cerebral cortex: 78.2222% (minimum 99%, Missing); heart muscle: 98.3240% (minimum 99%, Missing); hippocampal formation: 81.1060% (minimum 99%, Missing); hypothalamus: 96.1749% (minimum 99%, Missing); lung: 98.8764% (minimum 99%, Missing); skeletal muscle: 95.6522% (minimum 99%, Missing); spinal cord: 98.8764% (minimum 99%, Missing)",0,80,unavailable,8.8,0.5,0.2,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000160396,HIPK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.038764,0.00237569,-0.323333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,6.5,3.2,"colon: 6.5 nTPM (protected, limit 2); rectum: 4.7 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160471,COX6B2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.7654% (minimum 99%, Baseline (adaptation disabled)); colon: 93.1217% (minimum 97%, Baseline (adaptation disabled)); hypothalamus: 98.8764% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.9876% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.9299% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.1,6.5,3.2,"colon: 6.5 nTPM (protected, limit 2); rectum: 4.7 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160471,COX6B2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0149123,-0.0387831,-0.00234568
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.7654% (minimum 99%, Missing); colon: 93.1217% (minimum 97%, Missing); hypothalamus: 98.8764% (minimum 99%, Missing); pituitary gland: 98.9876% (minimum 99%, Missing); rectum: 94.9299% (minimum 97%, Missing)",0,80,unavailable,1.1,6.5,3.2,"colon: 6.5 nTPM (protected, limit 2); rectum: 4.7 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160471,COX6B2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0149123,-0.0387831,-0.00234568
True,compatible,,True,True,False,,0,80,unavailable,0.2,1.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000160505,NLRP4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 80.9524% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.1429% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1429% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,1.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000160505,NLRP4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0214286,-0.160476,-0.0185714
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 80.9524% (minimum 97%, Missing); midbrain: 97.1429% (minimum 99%, Missing); spinal cord: 97.1429% (minimum 99%, Missing)",0,80,unavailable,0.2,1.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000160505,NLRP4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0214286,-0.160476,-0.0185714
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.1,0,0.2,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000160838,LRRC71,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.0159% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.1089% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.2075% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.9944% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.5606% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.8571% (minimum 99%, Baseline (adaptation disabled)); lung: 91.4815% (minimum 99%, Baseline (adaptation disabled)); retina: 98.8000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,11.1,0,0.2,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000160838,LRRC71,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,0.0419679,0.03,-0.300056
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.0159% (minimum 99%, Missing); amygdala: 96.1089% (minimum 99%, Missing); basal ganglia: 93.2075% (minimum 99%, Missing); choroid plexus: 68.9944% (minimum 99%, Missing); hippocampal formation: 93.5606% (minimum 99%, Missing); hypothalamus: 92.8571% (minimum 99%, Missing); lung: 91.4815% (minimum 99%, Missing); retina: 98.8000% (minimum 99%, Missing); spinal cord: 98.8000% (minimum 99%, Missing)",0,80,unavailable,11.1,0,0.2,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000160838,LRRC71,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,0.0419679,0.03,-0.300056
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,3571.8,1.3,0.3,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 3)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000160882,CYP11B1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 0.1119% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.5610% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.5610% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.7805% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.2381% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.9091% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.9091% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.5610% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.5610% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 88.8889% (minimum 99%, Baseline (adaptation disabled)); lung: 93.0233% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.5610% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.9091% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.9091% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.4717% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.2381% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.0233% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.9091% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.2381% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,3571.8,1.3,0.3,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000160882,CYP11B1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0197674,-0.215283,-0.988881
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 0.1119% (minimum 99%, Missing); amygdala: 97.5610% (minimum 99%, Missing); basal ganglia: 97.5610% (minimum 99%, Missing); cerebellum: 48.7805% (minimum 97%, Supported); cerebral cortex: 95.2381% (minimum 97%, Supported); heart muscle: 90.9091% (minimum 97%, Supported); hippocampal formation: 97.5610% (minimum 99%, Missing); hypothalamus: 97.5610% (minimum 99%, Missing); kidney: 83.3333% (minimum 97%, Supported); liver: 88.8889% (minimum 97%, Supported); lung: 93.0233% (minimum 97%, Supported); midbrain: 97.5610% (minimum 99%, Missing); pancreas: 90.9091% (minimum 97%, Supported); pituitary gland: 90.9091% (minimum 99%, Missing); salivary gland: 75.4717% (minimum 90%, Supported); skeletal muscle: 95.2381% (minimum 97%, Supported); small intestine: 95.2381% (minimum 97%, Supported)",0,0,routine_complete,3571.8,1.3,0.3,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 3)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000160882,CYP11B1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.145283,-0.988881
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,5.2,12.1,6.6,"esophagus: 12.1 nTPM (protected, limit 12); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160886,LY6K,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.0647% (minimum 95%, Baseline (adaptation disabled)); amygdala: 94.8509% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.0860% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.9529% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.0851% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.3100% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.5946% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.8338% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.3483% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0392% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.5829% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.8701% (minimum 99%, Baseline (adaptation disabled)); retina: 93.8338% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.3678% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.0647% (minimum 99%, Baseline (adaptation disabled)); skin: 84.1346% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 95.3678% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.9529% (minimum 97%, Baseline (adaptation disabled)); tongue: 96.4187% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,5.2,12.1,6.6,"esophagus: 12.1 nTPM (protected, limit 2); skin: 6.6 nTPM (manageable, limit 5); adipose tissue: 5.2 nTPM (manageable, limit 5); skeletal muscle: 5.2 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160886,LY6K,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.108654,-0.2269,-0.119353
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 94.8509% (minimum 99%, Missing); basal ganglia: 94.0860% (minimum 99%, Missing); cerebral cortex: 93.0851% (minimum 95%, Enhanced); esophagus: 74.3100% (minimum 80%, Enhanced); hippocampal formation: 94.5946% (minimum 99%, Missing); hypothalamus: 93.8338% (minimum 99%, Missing); kidney: 92.3483% (minimum 95%, Enhanced); midbrain: 93.5829% (minimum 99%, Missing); pituitary gland: 98.8701% (minimum 99%, Missing); retina: 93.8338% (minimum 99%, Missing); skeletal muscle: 87.0647% (minimum 95%, Enhanced); spinal cord: 95.3678% (minimum 99%, Missing); tongue: 96.4187% (minimum 97%, Missing)",0,2,partial,5.2,12.1,6.6,"esophagus: 12.1 nTPM (protected, limit 12); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000160886,LY6K,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0331461,-0.0569002,-0.0793532
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,1,partial,0.2,0,0,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000160994,TEKTL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"pancreas: 98.6842% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.2,0,0,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000160994,TEKTL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.00315789
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,1,partial,0.2,0,0,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000160994,TEKTL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00684211
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,26.8,8.7,23.7,"cerebellum: 26.8 nTPM (vital, limit 6); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 6); adrenal gland: 16.2 nTPM (vital, limit 6); bone marrow: 14.8 nTPM (vital, limit 6); liver: 14.6 nTPM (vital, limit 6); hypothalamus: 13.8 nTPM (vital, limit 1); cerebral cortex: 13.8 nTPM (vital, limit 6); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 6); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); choroid plexus: 11 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 6); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); heart muscle: 9.4 nTPM (vital, limit 6); pancreas: 9 nTPM (vital, limit 6); spinal cord: 8.9 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000161036,LRWD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.2918% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.8110% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.1974% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.7592% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.8967% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.0959% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.0517% (minimum 99%, Baseline (adaptation disabled)); colon: 96.8863% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.0938% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.6065% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.5373% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.0959% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0517% (minimum 99%, Baseline (adaptation disabled)); liver: 94.8264% (minimum 99%, Baseline (adaptation disabled)); lung: 96.4672% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.2936% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7462% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.9565% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.9937% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7818% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.4691% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.1590% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.4910% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.7812% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.8641% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.8512% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.8863% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,26.8,8.7,23.7,"cerebellum: 26.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 1); adrenal gland: 16.2 nTPM (vital, limit 1); bone marrow: 14.8 nTPM (vital, limit 1); liver: 14.6 nTPM (vital, limit 1); cerebral cortex: 13.8 nTPM (vital, limit 1); hypothalamus: 13.8 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); choroid plexus: 11 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.4 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); colon: 8.6 nTPM (protected, limit 2); thymus: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 2); lymph node: 7.9 nTPM (protected, limit 2); adipose tissue: 7.9 nTPM (manageable, limit 5); esophagus: 7.5 nTPM (protected, limit 2); salivary gland: 7.3 nTPM (protected, limit 2); skin: 6.4 nTPM (manageable, limit 5); duodenum: 5.2 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 2); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000161036,LRWD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0313594,-0.00148751,-0.0810326
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.2918% (minimum 95%, Enhanced); amygdala: 95.8110% (minimum 99%, Missing); basal ganglia: 95.1974% (minimum 99%, Missing); bone marrow: 94.7592% (minimum 95%, Enhanced); cerebellum: 90.8967% (minimum 95%, Enhanced); choroid plexus: 96.0517% (minimum 99%, Missing); hippocampal formation: 95.5373% (minimum 99%, Missing); hypothalamus: 95.0959% (minimum 99%, Missing); liver: 94.8264% (minimum 95%, Enhanced); lung: 96.4672% (minimum 99%, Missing); midbrain: 96.2936% (minimum 99%, Missing); pituitary gland: 93.9937% (minimum 99%, Missing); retina: 98.7818% (minimum 99%, Missing); small intestine: 94.1590% (minimum 95%, Enhanced); spinal cord: 96.7812% (minimum 99%, Missing)",0,2,partial,26.8,8.7,23.7,"cerebellum: 26.8 nTPM (vital, limit 6); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 6); adrenal gland: 16.2 nTPM (vital, limit 6); bone marrow: 14.8 nTPM (vital, limit 6); liver: 14.6 nTPM (vital, limit 6); hypothalamus: 13.8 nTPM (vital, limit 1); cerebral cortex: 13.8 nTPM (vital, limit 6); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 6); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); choroid plexus: 11 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 6); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); heart muscle: 9.4 nTPM (vital, limit 6); pancreas: 9 nTPM (vital, limit 6); spinal cord: 8.9 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000161036,LRWD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0192141,0.0112981,-0.0500632
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,2.6,4.9,0.8,"stomach: 4.9 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161040,FBXL13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.4762% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.6981% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.4444% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.4762% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.0769% (minimum 99%, Baseline (adaptation disabled)); colon: 95.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.4762% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.4762% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.6829% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.4762% (minimum 99%, Baseline (adaptation disabled)); liver: 95.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 88.3721% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.6829% (minimum 97%, Baseline (adaptation disabled)); pancreas: 90.4762% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.6087% (minimum 97%, Baseline (adaptation disabled)); rectum: 95.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 59.3750% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.4359% (minimum 99%, Baseline (adaptation disabled)); skin: 86.3636% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.6829% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.6829% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.3721% (minimum 95%, Baseline (adaptation disabled)); stomach: 43.6782% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.3636% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.6087% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.6829% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,2.6,4.9,0.8,"stomach: 4.9 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161040,FBXL13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.123913,-0.533218,-0.39625
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.4762% (minimum 95%, Uncertain); adrenal gland: 71.6981% (minimum 99%, Missing); bone marrow: 84.4444% (minimum 99%, Missing); cerebral cortex: 90.4762% (minimum 99%, Missing); choroid plexus: 73.0769% (minimum 99%, Missing); colon: 95.0000% (minimum 97%, Missing); duodenum: 90.4762% (minimum 99%, Missing); esophagus: 90.4762% (minimum 97%, Missing); heart muscle: 92.6829% (minimum 99%, Missing); kidney: 90.4762% (minimum 99%, Missing); liver: 95.0000% (minimum 99%, Missing); lung: 88.3721% (minimum 99%, Missing); lymph node: 92.6829% (minimum 97%, Missing); pancreas: 90.4762% (minimum 99%, Missing); parathyroid gland: 82.6087% (minimum 97%, Missing); rectum: 95.0000% (minimum 97%, Uncertain); retina: 59.3750% (minimum 99%, Missing); salivary gland: 95.0000% (minimum 97%, Uncertain); skeletal muscle: 97.4359% (minimum 99%, Uncertain); skin: 86.3636% (minimum 95%, Missing); small intestine: 92.6829% (minimum 99%, Missing); smooth muscle: 92.6829% (minimum 99%, Missing); spleen: 88.3721% (minimum 95%, Missing); stomach: 43.6782% (minimum 97%, Missing); thymus: 86.3636% (minimum 95%, Missing); thyroid gland: 82.6087% (minimum 95%, Uncertain); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 92.6829% (minimum 97%, Missing)",0,2,partial,2.6,4.9,0.8,"stomach: 4.9 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161040,FBXL13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.123913,-0.533218,-0.39625
True,compatible,,True,True,False,,0,80,unavailable,0.6,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000161180,CCDC116,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.9726% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.6348% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2993% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6348% (minimum 99%, Baseline (adaptation disabled)); colon: 96.6555% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.9661% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9726% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9726% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2993% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9726% (minimum 99%, Baseline (adaptation disabled)); lung: 97.9661% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.9726% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6348% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.6348% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.9726% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.9661% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9726% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000161180,CCDC116,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.023064,-0.00344482,-0.010339
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.9726% (minimum 99%, Missing); basal ganglia: 98.6348% (minimum 99%, Missing); cerebellum: 98.2993% (minimum 99%, Missing); cerebral cortex: 98.6348% (minimum 99%, Missing); colon: 96.6555% (minimum 97%, Missing); heart muscle: 97.9661% (minimum 99%, Missing); hippocampal formation: 98.9726% (minimum 99%, Missing); hypothalamus: 98.9726% (minimum 99%, Missing); kidney: 98.2993% (minimum 99%, Missing); liver: 98.9726% (minimum 99%, Missing); lung: 97.9661% (minimum 99%, Missing); midbrain: 98.9726% (minimum 99%, Missing); pancreas: 98.6348% (minimum 99%, Missing); pituitary gland: 98.6348% (minimum 99%, Missing); skeletal muscle: 98.9726% (minimum 99%, Missing); small intestine: 97.9661% (minimum 99%, Missing); spinal cord: 98.9726% (minimum 99%, Missing)",0,80,unavailable,0.6,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000161180,CCDC116,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.023064,-0.00344482,-0.010339
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,71.2,40.4,41.8,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); skin: 41.8 nTPM (manageable, limit 5); tongue: 40.4 nTPM (protected, limit 2); adipose tissue: 30.3 nTPM (manageable, limit 5); esophagus: 29.9 nTPM (protected, limit 2); spleen: 25.3 nTPM (manageable, limit 5); colon: 24.8 nTPM (protected, limit 2); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 2); lymph node: 22.3 nTPM (protected, limit 2); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 2); parathyroid gland: 21.9 nTPM (protected, limit 2); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 2); liver: 20 nTPM (vital, limit 1); salivary gland: 18.7 nTPM (protected, limit 2); thymus: 17.8 nTPM (manageable, limit 5); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (manageable, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161217,PCYT1A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.8426% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 47.9121% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.6437% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.6437% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 32.6347% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 63.0058% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.2888% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 57.8249% (minimum 99%, Baseline (adaptation disabled)); colon: 46.7811% (minimum 97%, Baseline (adaptation disabled)); duodenum: 27.1144% (minimum 99%, Baseline (adaptation disabled)); esophagus: 42.1663% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 32.7327% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.5569% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.5819% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.1899% (minimum 99%, Baseline (adaptation disabled)); liver: 52.1531% (minimum 99%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.4331% (minimum 97%, Baseline (adaptation disabled)); midbrain: 58.7601% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.2178% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.8856% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.3721% (minimum 99%, Baseline (adaptation disabled)); rectum: 49.5455% (minimum 97%, Baseline (adaptation disabled)); retina: 61.0644% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.8272% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 23.4409% (minimum 99%, Baseline (adaptation disabled)); skin: 34.2767% (minimum 95%, Baseline (adaptation disabled)); small intestine: 31.3669% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 49.5455% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 58.1333% (minimum 99%, Baseline (adaptation disabled)); spleen: 46.2845% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.0176% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.0505% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.7708% (minimum 95%, Baseline (adaptation disabled)); tongue: 35.0482% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.9048% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,71.2,40.4,41.8,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); skin: 41.8 nTPM (manageable, limit 5); tongue: 40.4 nTPM (protected, limit 2); adipose tissue: 30.3 nTPM (manageable, limit 5); esophagus: 29.9 nTPM (protected, limit 2); spleen: 25.3 nTPM (manageable, limit 5); colon: 24.8 nTPM (protected, limit 2); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 2); lymph node: 22.3 nTPM (protected, limit 2); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 2); parathyroid gland: 21.9 nTPM (protected, limit 2); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 2); liver: 20 nTPM (vital, limit 1); salivary gland: 18.7 nTPM (protected, limit 2); thymus: 17.8 nTPM (manageable, limit 5); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (manageable, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161217,PCYT1A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.607233,-0.619518,-0.755591
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.8426% (minimum 95%, Missing); adrenal gland: 47.9121% (minimum 99%, Missing); amygdala: 62.6437% (minimum 99%, Missing); basal ganglia: 62.6437% (minimum 99%, Missing); bone marrow: 32.6347% (minimum 99%, Missing); cerebellum: 63.0058% (minimum 99%, Missing); cerebral cortex: 58.2888% (minimum 99%, Missing); choroid plexus: 57.8249% (minimum 99%, Missing); colon: 46.7811% (minimum 97%, Missing); duodenum: 27.1144% (minimum 99%, Missing); esophagus: 42.1663% (minimum 97%, Missing); heart muscle: 32.7327% (minimum 99%, Missing); hippocampal formation: 63.5569% (minimum 99%, Missing); hypothalamus: 61.5819% (minimum 99%, Missing); kidney: 55.1899% (minimum 99%, Missing); liver: 52.1531% (minimum 99%, Missing); lung: 50.0000% (minimum 99%, Missing); lymph node: 49.4331% (minimum 97%, Missing); midbrain: 58.7601% (minimum 99%, Missing); pancreas: 57.2178% (minimum 99%, Missing); parathyroid gland: 49.8856% (minimum 97%, Missing); pituitary gland: 63.3721% (minimum 99%, Missing); rectum: 49.5455% (minimum 97%, Missing); retina: 61.0644% (minimum 99%, Missing); salivary gland: 53.8272% (minimum 97%, Missing); skeletal muscle: 23.4409% (minimum 99%, Missing); skin: 34.2767% (minimum 95%, Missing); small intestine: 31.3669% (minimum 99%, Missing); smooth muscle: 49.5455% (minimum 99%, Missing); spinal cord: 58.1333% (minimum 99%, Missing); spleen: 46.2845% (minimum 95%, Missing); stomach: 48.0176% (minimum 97%, Missing); thymus: 55.0505% (minimum 95%, Missing); thyroid gland: 56.7708% (minimum 95%, Missing); tongue: 35.0482% (minimum 97%, Missing); urinary bladder: 51.9048% (minimum 97%, Missing)",0,1,partial,71.2,40.4,41.8,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); skin: 41.8 nTPM (manageable, limit 5); tongue: 40.4 nTPM (protected, limit 2); adipose tissue: 30.3 nTPM (manageable, limit 5); esophagus: 29.9 nTPM (protected, limit 2); spleen: 25.3 nTPM (manageable, limit 5); colon: 24.8 nTPM (protected, limit 2); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 2); lymph node: 22.3 nTPM (protected, limit 2); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 2); parathyroid gland: 21.9 nTPM (protected, limit 2); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 2); liver: 20 nTPM (vital, limit 1); salivary gland: 18.7 nTPM (protected, limit 2); thymus: 17.8 nTPM (manageable, limit 5); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (manageable, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161217,PCYT1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.607233,-0.619518,-0.755591
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,11.8,35.6,22.4,"lymph node: 35.6 nTPM (protected, limit 2); thymus: 22.4 nTPM (manageable, limit 5); spleen: 21.8 nTPM (manageable, limit 5); small intestine: 11.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); spleen / cells in white pulp: High (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000161405,IKZF3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 23.6842% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 36.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 34.6154% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.5455% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 78.2609% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.7368% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 48.6486% (minimum 99%, Baseline (adaptation disabled)); lung: 37.5000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 4.8128% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.7368% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.8182% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.7368% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.7368% (minimum 99%, Baseline (adaptation disabled)); rectum: 37.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 85.7143% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 46.1538% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.8182% (minimum 99%, Baseline (adaptation disabled)); skin: 69.2308% (minimum 95%, Baseline (adaptation disabled)); small intestine: 13.2353% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.2308% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 7.6271% (minimum 95%, Baseline (adaptation disabled)); stomach: 23.0769% (minimum 97%, Baseline (adaptation disabled)); thymus: 7.4380% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 85.7143% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 29.5082% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,11.8,35.6,22.4,"lymph node: 35.6 nTPM (protected, limit 2); thymus: 22.4 nTPM (manageable, limit 5); spleen: 21.8 nTPM (manageable, limit 5); small intestine: 11.8 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); bone marrow: 5.8 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); liver: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); spleen / cells in white pulp: High (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000161405,IKZF3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.87562,-0.921872,-0.857647
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 72.0000% (minimum 95%, Enhanced); bone marrow: 23.6842% (minimum 99%, Missing); cerebral cortex: 90.0000% (minimum 95%, Enhanced); choroid plexus: 90.0000% (minimum 99%, Missing); colon: 36.0000% (minimum 97%, Missing); duodenum: 34.6154% (minimum 99%, Missing); esophagus: 54.5455% (minimum 80%, Enhanced); heart muscle: 78.2609% (minimum 95%, Enhanced); hippocampal formation: 90.0000% (minimum 99%, Missing); hypothalamus: 94.7368% (minimum 99%, Missing); kidney: 75.0000% (minimum 95%, Enhanced); liver: 48.6486% (minimum 95%, Enhanced); lung: 37.5000% (minimum 99%, Missing); lymph node: 4.8128% (minimum 97%, Missing); midbrain: 94.7368% (minimum 99%, Missing); pancreas: 81.8182% (minimum 95%, Enhanced); pituitary gland: 94.7368% (minimum 99%, Missing); rectum: 37.5000% (minimum 97%, Missing); retina: 85.7143% (minimum 99%, Missing); salivary gland: 46.1538% (minimum 80%, Enhanced); skeletal muscle: 81.8182% (minimum 95%, Enhanced); small intestine: 13.2353% (minimum 99%, Missing); smooth muscle: 69.2308% (minimum 95%, Enhanced); spinal cord: 90.0000% (minimum 99%, Missing); spleen: 7.6271% (minimum 95%, Missing); stomach: 23.0769% (minimum 80%, Enhanced); thymus: 7.4380% (minimum 95%, Missing); tongue: 85.7143% (minimum 97%, Missing); urinary bladder: 29.5082% (minimum 80%, Enhanced)",0,8,partial,11.8,35.6,22.4,"lymph node: 35.6 nTPM (protected, limit 2); thymus: 22.4 nTPM (manageable, limit 5); spleen: 21.8 nTPM (manageable, limit 5); small intestine: 11.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); spleen / cells in white pulp: High (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000161405,IKZF3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.87562,-0.921872,-0.857647
True,compatible,,True,True,False,,0,2,partial,0.7,0.8,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000161594,KLHL10,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"smooth muscle: 98.7589% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.7,0.8,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000161594,KLHL10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0428699,0.0158407,-0.00241135
True,compatible,,True,True,True,,0,2,partial,0.7,0.8,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000161594,KLHL10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00464286
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,11.5,0,0,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161609,KASH5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 82.1705% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.5392% (minimum 99%, Baseline (adaptation disabled)); retina: 88.0399% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,11.5,0,0,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161609,KASH5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.168295
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 82.1705% (minimum 99%, Missing); pancreas: 96.5392% (minimum 99%, Missing); retina: 88.0399% (minimum 99%, Missing)",0,1,partial,11.5,0,0,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161609,KASH5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.168295
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000161652,IZUMO2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000161652,IZUMO2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0484102,0.03,0.00841017
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000161652,IZUMO2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0484102,0.03,0.00841017
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,35.8,27.3,19.4,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 2); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 2); tongue: 22.8 nTPM (protected, limit 2); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 2); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 2); lymph node: 20.3 nTPM (protected, limit 2); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); adipose tissue: 19.3 nTPM (manageable, limit 10); stomach: 19.3 nTPM (protected, limit 2); colon: 19.1 nTPM (protected, limit 2); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (manageable, limit 5); salivary gland: 17.6 nTPM (protected, limit 2); spleen: 16.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 16 nTPM (vital, limit 1); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161654,LSM12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8352% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 53.5088% (minimum 99%, Baseline (adaptation disabled)); amygdala: 54.8315% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 59.3674% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 45.5224% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 59.6577% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.8631% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.3960% (minimum 99%, Baseline (adaptation disabled)); colon: 56.0920% (minimum 97%, Baseline (adaptation disabled)); duodenum: 59.3674% (minimum 99%, Baseline (adaptation disabled)); esophagus: 47.1954% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.6998% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 56.3510% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 52.4731% (minimum 99%, Baseline (adaptation disabled)); kidney: 54.7085% (minimum 99%, Baseline (adaptation disabled)); liver: 46.1248% (minimum 99%, Baseline (adaptation disabled)); lung: 59.9509% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.5861% (minimum 97%, Baseline (adaptation disabled)); midbrain: 55.0790% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.2605% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 53.9823% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.8743% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.5856% (minimum 97%, Baseline (adaptation disabled)); retina: 44.6069% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.0952% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 40.5316% (minimum 99%, Baseline (adaptation disabled)); skin: 60.0985% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.8039% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.4545% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.7442% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.2233% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.8352% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.7078% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.9572% (minimum 95%, Baseline (adaptation disabled)); tongue: 51.6949% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.5862% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,35.8,27.3,19.4,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 2); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 2); tongue: 22.8 nTPM (protected, limit 2); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 2); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 2); lymph node: 20.3 nTPM (protected, limit 2); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); adipose tissue: 19.3 nTPM (manageable, limit 5); stomach: 19.3 nTPM (protected, limit 2); colon: 19.1 nTPM (protected, limit 2); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (manageable, limit 5); salivary gland: 17.6 nTPM (protected, limit 2); spleen: 16.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 16 nTPM (vital, limit 1); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161654,LSM12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.392922,-0.498046,-0.584684
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8352% (minimum 90%, Approved); adrenal gland: 53.5088% (minimum 99%, Missing); amygdala: 54.8315% (minimum 99%, Missing); basal ganglia: 59.3674% (minimum 99%, Missing); bone marrow: 45.5224% (minimum 99%, Missing); cerebellum: 59.6577% (minimum 99%, Missing); cerebral cortex: 53.8631% (minimum 99%, Missing); choroid plexus: 60.3960% (minimum 99%, Missing); colon: 56.0920% (minimum 97%, Missing); duodenum: 59.3674% (minimum 99%, Missing); esophagus: 47.1954% (minimum 97%, Missing); heart muscle: 52.6998% (minimum 99%, Missing); hippocampal formation: 56.3510% (minimum 99%, Missing); hypothalamus: 52.4731% (minimum 99%, Missing); kidney: 54.7085% (minimum 99%, Missing); liver: 46.1248% (minimum 99%, Missing); lung: 59.9509% (minimum 99%, Missing); lymph node: 54.5861% (minimum 97%, Missing); midbrain: 55.0790% (minimum 99%, Missing); pancreas: 51.2605% (minimum 99%, Missing); parathyroid gland: 53.9823% (minimum 97%, Missing); pituitary gland: 63.8743% (minimum 99%, Missing); rectum: 51.5856% (minimum 97%, Missing); retina: 44.6069% (minimum 99%, Missing); salivary gland: 58.0952% (minimum 97%, Missing); skeletal muscle: 40.5316% (minimum 99%, Missing); skin: 60.0985% (minimum 95%, Missing); small intestine: 59.8039% (minimum 99%, Missing); smooth muscle: 55.4545% (minimum 99%, Missing); spinal cord: 56.7442% (minimum 99%, Missing); spleen: 59.2233% (minimum 95%, Missing); stomach: 55.8352% (minimum 97%, Missing); thymus: 55.7078% (minimum 95%, Missing); thyroid gland: 57.9572% (minimum 95%, Missing); tongue: 51.6949% (minimum 97%, Missing); urinary bladder: 52.5862% (minimum 97%, Missing)",0,2,partial,35.8,27.3,19.4,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 2); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 2); tongue: 22.8 nTPM (protected, limit 2); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 2); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 2); lymph node: 20.3 nTPM (protected, limit 2); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); adipose tissue: 19.3 nTPM (manageable, limit 10); stomach: 19.3 nTPM (protected, limit 2); colon: 19.1 nTPM (protected, limit 2); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (manageable, limit 5); salivary gland: 17.6 nTPM (protected, limit 2); spleen: 16.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 16 nTPM (vital, limit 1); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000161654,LSM12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.392922,-0.498046,-0.584684
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,14.9,604.8,109,"salivary gland: 604.8 nTPM (protected, limit 2); skin: 109 nTPM (manageable, limit 30); stomach: 51 nTPM (protected, limit 2); esophagus: 16 nTPM (protected, limit 12); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); salivary gland / glandular cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; salivary gland / glandular cells; skin; spleen; tonsil,ENSG00000161798,AQP5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.6295% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.4718% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.9006% (minimum 99%, Baseline (adaptation disabled)); duodenum: 93.5442% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.1005% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.2704% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7649% (minimum 99%, Baseline (adaptation disabled)); lung: 96.6861% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.1364% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 26.3068% (minimum 97%, Baseline (adaptation disabled)); skin: 66.4512% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.8917% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,14.9,604.8,109,"salivary gland: 604.8 nTPM (protected, limit 2); skin: 109 nTPM (manageable, limit 5); stomach: 51 nTPM (protected, limit 2); esophagus: 16 nTPM (protected, limit 2); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); salivary gland / glandular cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; salivary gland / glandular cells; skin; spleen; tonsil,ENSG00000161798,AQP5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.285488,-0.706932,-0.0545581
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.6295% (minimum 99%, Missing); basal ganglia: 97.4718% (minimum 99%, Missing); duodenum: 93.5442% (minimum 99%, Missing); hypothalamus: 98.7649% (minimum 99%, Missing); midbrain: 98.1364% (minimum 99%, Missing); salivary gland: 26.3068% (minimum 97%, Missing); stomach: 80.8917% (minimum 97%, Missing)",0,2,partial,14.9,604.8,109,"salivary gland: 604.8 nTPM (protected, limit 2); skin: 109 nTPM (manageable, limit 30); stomach: 51 nTPM (protected, limit 2); esophagus: 16 nTPM (protected, limit 12); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); salivary gland / glandular cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; salivary gland / glandular cells; skin; spleen; tonsil,ENSG00000161798,AQP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,-0.706932,-0.0545581
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,2,partial,0,0,12.3,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in cuticle; skin,ENSG00000161850,KRT82,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 25.0000% (minimum 95%, Baseline (adaptation disabled)); skin: 0.8065% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,0,0,12.3,"skin: 12.3 nTPM (manageable, limit 5)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in cuticle; skin,ENSG00000161850,KRT82,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.941935,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 25.0000% (minimum 60%, Enhanced); skin: 0.8065% (minimum 60%, Enhanced)",0,2,partial,0,0,12.3,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in cuticle; skin,ENSG00000161850,KRT82,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.591935,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,3.2,1.1,1.8,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000161860,SYCE2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.1061% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.7358% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.3684% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.0034% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.1972% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.8718% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.1061% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.8550% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.1061% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.3684% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.1061% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.3684% (minimum 99%, Baseline (adaptation disabled)); liver: 93.8406% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1061% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.9259% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.7358% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7358% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.0037% (minimum 99%, Baseline (adaptation disabled)); retina: 94.8718% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.8550% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.7358% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.3684% (minimum 99%, Baseline (adaptation disabled)); thymus: 93.5018% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,3.2,1.1,1.8,"bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000161860,SYCE2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0149819,-0.0107407,-0.0999656
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7358% (minimum 99%, Missing); basal ganglia: 97.3684% (minimum 99%, Missing); bone marrow: 89.0034% (minimum 95%, Enhanced); cerebellum: 91.1972% (minimum 95%, Enhanced); cerebral cortex: 94.8718% (minimum 95%, Enhanced); choroid plexus: 98.1061% (minimum 99%, Missing); hippocampal formation: 97.3684% (minimum 99%, Missing); hypothalamus: 98.1061% (minimum 99%, Missing); liver: 93.8406% (minimum 95%, Enhanced); midbrain: 97.7358% (minimum 99%, Missing); pituitary gland: 97.0037% (minimum 99%, Missing); retina: 94.8718% (minimum 99%, Missing); spinal cord: 97.3684% (minimum 99%, Missing); thymus: 93.5018% (minimum 95%, Missing)",0,1,partial,3.2,1.1,1.8,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000161860,SYCE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0149819,0.03,-0.0599656
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000161973,CCDC42,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000161973,CCDC42,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0478402,0.0278402,0.00784017
True,compatible,,True,True,True,,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000161973,CCDC42,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0478402,0.0278402,0.00784017
True,compatible,,True,True,False,,0,80,unavailable,0.7,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,ENSG00000162039,MEIOB,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.5130% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5130% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.5130% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8806% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.1481% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8806% (minimum 99%, Baseline (adaptation disabled)); retina: 97.4265% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,ENSG00000162039,MEIOB,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.020696,0.0262406,-0.0157353
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.5130% (minimum 99%, Missing); basal ganglia: 98.5130% (minimum 99%, Missing); cerebral cortex: 98.5130% (minimum 99%, Missing); hypothalamus: 98.8806% (minimum 99%, Missing); kidney: 98.1481% (minimum 99%, Missing); liver: 98.8806% (minimum 99%, Missing); retina: 97.4265% (minimum 99%, Missing)",0,80,unavailable,0.7,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,ENSG00000162039,MEIOB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.020696,0.0262406,-0.0157353
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,4,2.2,2.1,"bone marrow: 4 nTPM (vital, limit 2); lymph node: 2.1 nTPM (protected, limit 2); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells,ENSG00000162062,TEDC2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.1176% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.7586% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.5455% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.7586% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.5882% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.9592% (minimum 99%, Baseline (adaptation disabled)); colon: 82.7586% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.1905% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.5714% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.3559% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.8889% (minimum 99%, Baseline (adaptation disabled)); liver: 85.7143% (minimum 99%, Baseline (adaptation disabled)); lung: 92.3077% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.5652% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.2105% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.8889% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.2727% (minimum 97%, Baseline (adaptation disabled)); retina: 96.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.8889% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); skin: 84.2105% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.6885% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.7143% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.5652% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.1176% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.3077% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,4,2.2,2.1,"bone marrow: 4 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells,ENSG00000162062,TEDC2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.254348,-0.284286,-0.444545
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 85.7143% (minimum 98%, Approved); amygdala: 82.7586% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 54.5455% (minimum 98%, Approved); cerebellum: 82.7586% (minimum 98%, Approved); cerebral cortex: 70.5882% (minimum 98%, Approved); choroid plexus: 97.9592% (minimum 99%, Missing); colon: 82.7586% (minimum 95%, Approved); duodenum: 76.1905% (minimum 99%, Missing); esophagus: 68.5714% (minimum 95%, Approved); heart muscle: 85.7143% (minimum 98%, Approved); hippocampal formation: 81.3559% (minimum 99%, Missing); hypothalamus: 80.0000% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 85.7143% (minimum 98%, Approved); lung: 92.3077% (minimum 99%, Missing); lymph node: 69.5652% (minimum 97%, Missing); midbrain: 84.2105% (minimum 99%, Missing); pancreas: 88.8889% (minimum 98%, Approved); pituitary gland: 85.7143% (minimum 99%, Missing); rectum: 87.2727% (minimum 97%, Missing); retina: 96.0000% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 95%, Approved); skeletal muscle: 94.1176% (minimum 99%, Missing); skin: 84.2105% (minimum 90%, Approved); small intestine: 78.6885% (minimum 98%, Approved); smooth muscle: 94.1176% (minimum 98%, Approved); spinal cord: 88.8889% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 85.7143% (minimum 95%, Approved); thymus: 69.5652% (minimum 95%, Missing); thyroid gland: 94.1176% (minimum 95%, Missing); urinary bladder: 92.3077% (minimum 97%, Missing)",0,3,partial,4,2.2,2.1,"bone marrow: 4 nTPM (vital, limit 2); lymph node: 2.1 nTPM (protected, limit 2); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells,ENSG00000162062,TEDC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.254348,-0.274348,-0.434545
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,10,7.5,5.3,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 2); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 2); pancreas: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162129,CLPB,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.2832% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.7509% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.6637% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.2547% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.1014% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.0351% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.3660% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.8383% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.9259% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.2043% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.1895% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.0136% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.8139% (minimum 99%, Baseline (adaptation disabled)); liver: 91.4676% (minimum 99%, Baseline (adaptation disabled)); lung: 97.0136% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.5766% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.0355% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.4612% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.0787% (minimum 99%, Baseline (adaptation disabled)); retina: 94.6161% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.1198% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.8139% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.7211% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.4586% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1014% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.8383% (minimum 97%, Baseline (adaptation disabled)); tongue: 94.6996% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,10,7.5,5.3,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 2); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 2); pancreas: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162129,CLPB,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00288889,-0.035388,-0.0753242
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.2832% (minimum 99%, Missing); amygdala: 96.7509% (minimum 99%, Missing); basal ganglia: 96.6637% (minimum 99%, Missing); bone marrow: 92.2547% (minimum 99%, Missing); cerebellum: 97.1014% (minimum 99%, Missing); cerebral cortex: 94.0351% (minimum 99%, Missing); choroid plexus: 97.3660% (minimum 99%, Missing); duodenum: 96.8383% (minimum 99%, Missing); esophagus: 96.9259% (minimum 97%, Missing); heart muscle: 95.2043% (minimum 99%, Missing); hippocampal formation: 97.1895% (minimum 99%, Missing); hypothalamus: 97.0136% (minimum 99%, Missing); kidney: 92.8139% (minimum 99%, Missing); liver: 91.4676% (minimum 99%, Missing); lung: 97.0136% (minimum 99%, Missing); midbrain: 96.5766% (minimum 99%, Missing); pancreas: 95.0355% (minimum 99%, Missing); parathyroid gland: 93.4612% (minimum 97%, Missing); pituitary gland: 98.0787% (minimum 99%, Missing); retina: 94.6161% (minimum 99%, Missing); salivary gland: 95.1198% (minimum 97%, Missing); skeletal muscle: 92.8139% (minimum 99%, Missing); small intestine: 97.7211% (minimum 99%, Missing); smooth muscle: 95.4586% (minimum 99%, Missing); spinal cord: 97.1014% (minimum 99%, Missing); stomach: 96.8383% (minimum 97%, Missing); tongue: 94.6996% (minimum 97%, Missing)",0,3,partial,10,7.5,5.3,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 2); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 2); pancreas: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162129,CLPB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00288889,-0.035388,-0.0753242
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,14,partial,52,7.1,11.1,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 6); liver: 7.5 nTPM (vital, limit 6); cerebral cortex: 7.1 nTPM (vital, limit 6); cerebellum: 7 nTPM (vital, limit 6); kidney: 6.3 nTPM (vital, limit 6); thymus: 6.3 nTPM (manageable, limit 5); colon: 6.2 nTPM (protected, limit 2); midbrain: 5.6 nTPM (vital, limit 1); spinal cord: 5.2 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162148,SAXO4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.7040% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.5079% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.3242% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.3663% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.4099% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.8717% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.7772% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.6872% (minimum 99%, Baseline (adaptation disabled)); colon: 93.6345% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.2025% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.4974% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.4455% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.6097% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.5385% (minimum 99%, Baseline (adaptation disabled)); liver: 92.4012% (minimum 99%, Baseline (adaptation disabled)); lung: 89.5874% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.7772% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.2149% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.3041% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 87.0229% (minimum 99%, Baseline (adaptation disabled)); retina: 97.3319% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.8991% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.3975% (minimum 99%, Baseline (adaptation disabled)); skin: 89.1496% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.1983% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.6058% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.6829% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.6978% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.5385% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.5975% (minimum 97%, Baseline (adaptation disabled))",0,14,partial,52,7.1,11.1,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); skin: 11.1 nTPM (manageable, limit 5); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); lymph node: 7.1 nTPM (protected, limit 2); cerebral cortex: 7.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); colon: 6.2 nTPM (protected, limit 2); midbrain: 5.6 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); spinal cord: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); stomach: 4.1 nTPM (protected, limit 2); salivary gland: 3.9 nTPM (protected, limit 2); duodenum: 3.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162148,SAXO4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0585044,-0.0422279,-0.353128
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 89.3242% (minimum 99%, Missing); basal ganglia: 84.3663% (minimum 99%, Missing); bone marrow: 94.4099% (minimum 95%, Enhanced); cerebellum: 92.8717% (minimum 95%, Enhanced); cerebral cortex: 92.7772% (minimum 95%, Enhanced); choroid plexus: 63.6872% (minimum 99%, Missing); colon: 93.6345% (minimum 97%, Missing); duodenum: 96.2025% (minimum 99%, Missing); hippocampal formation: 86.4455% (minimum 99%, Missing); hypothalamus: 86.6097% (minimum 99%, Missing); kidney: 93.5385% (minimum 95%, Enhanced); liver: 92.4012% (minimum 95%, Enhanced); lung: 89.5874% (minimum 95%, Enhanced); midbrain: 94.2149% (minimum 99%, Missing); pituitary gland: 87.0229% (minimum 99%, Missing); retina: 97.3319% (minimum 99%, Missing); small intestine: 95.0000% (minimum 99%, Missing); spinal cord: 94.6058% (minimum 99%, Missing); thymus: 93.5385% (minimum 95%, Missing)",0,14,partial,52,7.1,11.1,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 6); liver: 7.5 nTPM (vital, limit 6); cerebral cortex: 7.1 nTPM (vital, limit 6); cerebellum: 7 nTPM (vital, limit 6); kidney: 6.3 nTPM (vital, limit 6); thymus: 6.3 nTPM (manageable, limit 5); colon: 6.2 nTPM (protected, limit 2); midbrain: 5.6 nTPM (vital, limit 1); spinal cord: 5.2 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162148,SAXO4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0146154,-0.033655,-0.353128
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,39.5,30.1,34.1,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); skin: 34.1 nTPM (manageable, limit 5); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); spinal cord: 30.1 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 2); salivary gland: 29.9 nTPM (protected, limit 2); adipose tissue: 29.8 nTPM (manageable, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 2); colon: 29.5 nTPM (protected, limit 2); esophagus: 29.1 nTPM (protected, limit 2); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (manageable, limit 5); hypothalamus: 25 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 2); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 2); thymus: 10.7 nTPM (manageable, limit 5); rectum: 8.8 nTPM (protected, limit 2); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162300,ZFPL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6623% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 49.2754% (minimum 99%, Baseline (adaptation disabled)); amygdala: 52.1295% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 49.9184% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 51.4286% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.1963% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 52.2184% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 48.1132% (minimum 99%, Baseline (adaptation disabled)); colon: 50.9151% (minimum 97%, Baseline (adaptation disabled)); duodenum: 63.7500% (minimum 99%, Baseline (adaptation disabled)); esophagus: 51.2563% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 50.7463% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 51.3423% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.0360% (minimum 99%, Baseline (adaptation disabled)); kidney: 52.9412% (minimum 99%, Baseline (adaptation disabled)); liver: 49.0385% (minimum 99%, Baseline (adaptation disabled)); lung: 59.6491% (minimum 99%, Baseline (adaptation disabled)); lymph node: 72.5118% (minimum 97%, Baseline (adaptation disabled)); midbrain: 49.7561% (minimum 99%, Baseline (adaptation disabled)); pancreas: 49.5948% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.9584% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 43.6519% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.6650% (minimum 97%, Baseline (adaptation disabled)); retina: 80.7388% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.5785% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 45.6036% (minimum 99%, Baseline (adaptation disabled)); skin: 47.2952% (minimum 95%, Baseline (adaptation disabled)); small intestine: 52.8497% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.4953% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.4119% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.2347% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.9151% (minimum 97%, Baseline (adaptation disabled)); thymus: 74.0920% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.7786% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.9562% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.4119% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,39.5,30.1,34.1,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); skin: 34.1 nTPM (manageable, limit 5); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); spinal cord: 30.1 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 2); salivary gland: 29.9 nTPM (protected, limit 2); adipose tissue: 29.8 nTPM (manageable, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 2); colon: 29.5 nTPM (protected, limit 2); esophagus: 29.1 nTPM (protected, limit 2); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (manageable, limit 5); hypothalamus: 25 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 2); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 2); thymus: 10.7 nTPM (manageable, limit 5); rectum: 8.8 nTPM (protected, limit 2); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162300,ZFPL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.477048,-0.465881,-0.553481
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6623% (minimum 95%, Missing); adrenal gland: 49.2754% (minimum 99%, Missing); amygdala: 52.1295% (minimum 99%, Missing); basal ganglia: 49.9184% (minimum 99%, Missing); bone marrow: 51.4286% (minimum 99%, Missing); cerebellum: 57.1963% (minimum 99%, Missing); cerebral cortex: 52.2184% (minimum 99%, Missing); choroid plexus: 48.1132% (minimum 99%, Missing); colon: 50.9151% (minimum 97%, Missing); duodenum: 63.7500% (minimum 99%, Missing); esophagus: 51.2563% (minimum 97%, Missing); heart muscle: 50.7463% (minimum 99%, Missing); hippocampal formation: 51.3423% (minimum 99%, Missing); hypothalamus: 55.0360% (minimum 99%, Missing); kidney: 52.9412% (minimum 99%, Missing); liver: 49.0385% (minimum 99%, Missing); lung: 59.6491% (minimum 99%, Missing); lymph node: 72.5118% (minimum 97%, Missing); midbrain: 49.7561% (minimum 99%, Missing); pancreas: 49.5948% (minimum 99%, Missing); parathyroid gland: 66.9584% (minimum 97%, Missing); pituitary gland: 43.6519% (minimum 99%, Missing); rectum: 77.6650% (minimum 97%, Missing); retina: 80.7388% (minimum 99%, Missing); salivary gland: 50.5785% (minimum 97%, Missing); skeletal muscle: 45.6036% (minimum 99%, Missing); skin: 47.2952% (minimum 95%, Missing); small intestine: 52.8497% (minimum 99%, Missing); smooth muscle: 71.4953% (minimum 99%, Missing); spinal cord: 50.4119% (minimum 99%, Missing); spleen: 55.2347% (minimum 95%, Missing); stomach: 50.9151% (minimum 97%, Missing); thymus: 74.0920% (minimum 95%, Missing); thyroid gland: 53.7786% (minimum 95%, Missing); tongue: 60.9562% (minimum 97%, Missing); urinary bladder: 50.4119% (minimum 97%, Missing)",0,7,partial,39.5,30.1,34.1,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); skin: 34.1 nTPM (manageable, limit 5); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); spinal cord: 30.1 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 2); salivary gland: 29.9 nTPM (protected, limit 2); adipose tissue: 29.8 nTPM (manageable, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 2); colon: 29.5 nTPM (protected, limit 2); esophagus: 29.1 nTPM (protected, limit 2); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (manageable, limit 5); hypothalamus: 25 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 2); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 2); thymus: 10.7 nTPM (manageable, limit 5); rectum: 8.8 nTPM (protected, limit 2); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162300,ZFPL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.477048,-0.465881,-0.553481
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12.5,3.7,4.6,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); stomach: 2.1 nTPM (protected, limit 2); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000162526,TSSK3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7677% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.7171% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.8060% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5119% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.5877% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.9740% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.0674% (minimum 99%, Baseline (adaptation disabled)); colon: 94.0341% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.9341% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.2209% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.6647% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5119% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8060% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.5714% (minimum 99%, Baseline (adaptation disabled)); liver: 92.7171% (minimum 99%, Baseline (adaptation disabled)); lung: 92.7171% (minimum 99%, Baseline (adaptation disabled)); lymph node: 89.9457% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.8060% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.0341% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.3890% (minimum 99%, Baseline (adaptation disabled)); retina: 88.7399% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.5028% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.9444% (minimum 99%, Baseline (adaptation disabled)); skin: 87.7984% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.4595% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5119% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.7399% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.0341% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.7677% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.1149% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,12.5,3.7,4.6,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); stomach: 2.1 nTPM (protected, limit 2); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000162526,TSSK3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0720159,-0.0705435,-0.264123
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7677% (minimum 95%, Missing); adrenal gland: 92.7171% (minimum 99%, Missing); amygdala: 98.8060% (minimum 99%, Missing); basal ganglia: 98.5119% (minimum 99%, Missing); bone marrow: 72.5877% (minimum 99%, Missing); cerebellum: 85.9740% (minimum 99%, Missing); cerebral cortex: 97.0674% (minimum 99%, Missing); colon: 94.0341% (minimum 97%, Missing); duodenum: 90.9341% (minimum 99%, Missing); esophagus: 96.2209% (minimum 97%, Missing); heart muscle: 95.6647% (minimum 99%, Missing); hippocampal formation: 98.5119% (minimum 99%, Missing); hypothalamus: 98.8060% (minimum 99%, Missing); kidney: 94.5714% (minimum 99%, Missing); liver: 92.7171% (minimum 99%, Missing); lung: 92.7171% (minimum 99%, Missing); lymph node: 89.9457% (minimum 97%, Missing); midbrain: 98.8060% (minimum 99%, Missing); pancreas: 94.0341% (minimum 99%, Missing); pituitary gland: 95.3890% (minimum 99%, Missing); retina: 88.7399% (minimum 99%, Missing); salivary gland: 93.5028% (minimum 97%, Missing); skeletal muscle: 91.9444% (minimum 99%, Missing); skin: 87.7984% (minimum 95%, Missing); small intestine: 89.4595% (minimum 99%, Missing); spinal cord: 98.5119% (minimum 99%, Missing); spleen: 88.7399% (minimum 95%, Missing); stomach: 94.0341% (minimum 97%, Missing); thyroid gland: 93.7677% (minimum 95%, Missing); urinary bladder: 95.1149% (minimum 97%, Missing)",0,80,unavailable,12.5,3.7,4.6,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); stomach: 2.1 nTPM (protected, limit 2); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000162526,TSSK3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0720159,-0.0705435,-0.264123
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,23.1,9.3,5.3,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 2); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lung: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); esophagus: 3.9 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000162543,UBXN10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.3684% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.1717% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.2475% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.0080% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.7642% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.1292% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.5562% (minimum 99%, Baseline (adaptation disabled)); colon: 83.7979% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.3640% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.3981% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.8167% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.4990% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0080% (minimum 99%, Baseline (adaptation disabled)); liver: 89.4052% (minimum 99%, Baseline (adaptation disabled)); lung: 90.4135% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.6262% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.9758% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.0985% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.3137% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.2713% (minimum 97%, Baseline (adaptation disabled)); retina: 95.8167% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.2000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.7622% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.9633% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.6262% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 90.0749% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.0593% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,23.1,9.3,5.3,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 2); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lung: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); esophagus: 3.9 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000162543,UBXN10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0492509,-0.132021,-0.314438
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.3684% (minimum 99%, Missing); amygdala: 97.1717% (minimum 99%, Missing); basal ganglia: 95.2475% (minimum 99%, Missing); bone marrow: 96.0080% (minimum 99%, Missing); cerebellum: 97.7642% (minimum 99%, Missing); cerebral cortex: 94.1292% (minimum 99%, Missing); choroid plexus: 67.5562% (minimum 99%, Missing); colon: 83.7979% (minimum 97%, Missing); duodenum: 98.3640% (minimum 99%, Missing); esophagus: 92.5000% (minimum 97%, Missing); heart muscle: 93.3981% (minimum 99%, Missing); hippocampal formation: 95.8167% (minimum 99%, Missing); hypothalamus: 94.4990% (minimum 99%, Missing); kidney: 96.0080% (minimum 99%, Missing); liver: 89.4052% (minimum 99%, Missing); lung: 90.4135% (minimum 99%, Missing); midbrain: 95.6262% (minimum 99%, Missing); pancreas: 96.9758% (minimum 99%, Missing); parathyroid gland: 91.0985% (minimum 97%, Missing); pituitary gland: 94.3137% (minimum 99%, Missing); rectum: 91.2713% (minimum 97%, Missing); retina: 95.8167% (minimum 99%, Missing); small intestine: 96.2000% (minimum 99%, Missing); smooth muscle: 93.7622% (minimum 99%, Missing); spinal cord: 97.9633% (minimum 99%, Missing); stomach: 95.6262% (minimum 97%, Missing); thyroid gland: 90.0749% (minimum 95%, Missing); urinary bladder: 95.0593% (minimum 97%, Missing)",0,2,partial,23.1,9.3,5.3,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 2); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lung: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); esophagus: 3.9 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000162543,UBXN10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0492509,-0.132021,-0.314438
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,0.5,1.2,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000162571,TTLL10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 93.3638% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7893% (minimum 99%, Baseline (adaptation disabled)); lung: 93.7931% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.3271% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.9,0.5,1.2,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000162571,TTLL10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.0214286,0.0178935,-0.0563616
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 93.3638% (minimum 99%, Missing); hypothalamus: 98.7893% (minimum 99%, Missing); lung: 93.7931% (minimum 99%, Missing); pituitary gland: 95.3271% (minimum 99%, Missing)",0,80,unavailable,2.9,0.5,1.2,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000162571,TTLL10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.0214286,0.0178935,-0.0563616
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000162592,CCDC27,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 98.8024% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000162592,CCDC27,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0439759,0.0239759,-0.00197605
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 98.8024% (minimum 99%, Missing)",0,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000162592,CCDC27,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0439759,0.0239759,-0.00197605
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,1.9,1.2,1.6,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162620,LRRIQ3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.5234% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.5854% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5075% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5075% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.0930% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5075% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5075% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.5369% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.2442% (minimum 99%, Baseline (adaptation disabled)); liver: 95.6522% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5075% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.5854% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.0588% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.2857% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.5369% (minimum 99%, Baseline (adaptation disabled)); retina: 97.5369% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.0588% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 93.3962% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,1.9,1.2,1.6,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162620,LRRIQ3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,-0.0247664,-0.0271429,-0.0775576
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.5854% (minimum 98%, Approved); amygdala: 98.5075% (minimum 99%, Missing); basal ganglia: 98.5075% (minimum 99%, Missing); choroid plexus: 92.0930% (minimum 99%, Missing); hippocampal formation: 98.5075% (minimum 99%, Missing); hypothalamus: 97.5369% (minimum 99%, Missing); kidney: 91.2442% (minimum 99%, Missing); liver: 95.6522% (minimum 98%, Approved); midbrain: 97.0588% (minimum 99%, Missing); parathyroid gland: 94.2857% (minimum 97%, Missing); pituitary gland: 97.5369% (minimum 99%, Missing); retina: 97.5369% (minimum 99%, Missing); spinal cord: 97.0588% (minimum 99%, Missing)",0,6,partial,1.9,1.2,1.6,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162620,LRRIQ3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,0.00652174,-0.0271429,-0.0775576
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.3,2.6,0.2,"salivary gland: 2.6 nTPM (protected, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; tonsil,ENSG00000162624,LHX8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 43.4783% (minimum 99%, Baseline (adaptation disabled)); esophagus: 58.8235% (minimum 97%, Baseline (adaptation disabled)); hypothalamus: 76.9231% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 27.7778% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 83.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.6667% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.3,2.6,0.2,"salivary gland: 2.6 nTPM (protected, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; tonsil,ENSG00000162624,LHX8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.116667,-0.692222,-0.555217
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 43.4783% (minimum 99%, Missing); esophagus: 58.8235% (minimum 97%, Missing); hypothalamus: 76.9231% (minimum 99%, Missing); salivary gland: 27.7778% (minimum 97%, Missing); thyroid gland: 83.3333% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 66.6667% (minimum 97%, Missing)",0,80,unavailable,1.3,2.6,0.2,"salivary gland: 2.6 nTPM (protected, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; tonsil,ENSG00000162624,LHX8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.116667,-0.692222,-0.555217
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,13.1,13.1,18.2,"thymus: 18.2 nTPM (manageable, limit 5); lymph node: 13.1 nTPM (protected, limit 2); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); spleen: 10.8 nTPM (manageable, limit 5); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 2); amygdala: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); urinary bladder: 6 nTPM (protected, limit 2); tongue: 5.9 nTPM (protected, limit 2); adipose tissue: 5.2 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162639,HENMT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.0759% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.0165% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.8458% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.2659% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.2169% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.3320% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.0837% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.3122% (minimum 99%, Baseline (adaptation disabled)); colon: 91.7323% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.5743% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.4138% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.6257% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.4269% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.9332% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.4918% (minimum 99%, Baseline (adaptation disabled)); liver: 97.3538% (minimum 99%, Baseline (adaptation disabled)); lung: 93.8255% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.2169% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.8141% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.2184% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.2000% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.3692% (minimum 97%, Baseline (adaptation disabled)); retina: 96.0165% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0165% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.7534% (minimum 99%, Baseline (adaptation disabled)); skin: 94.9728% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.4269% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.3615% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.2576% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.6171% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.8255% (minimum 97%, Baseline (adaptation disabled)); thymus: 79.3417% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.2164% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.0949% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,13.1,13.1,18.2,"thymus: 18.2 nTPM (manageable, limit 5); lymph node: 13.1 nTPM (protected, limit 2); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); spleen: 10.8 nTPM (manageable, limit 5); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 2); amygdala: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); urinary bladder: 6 nTPM (protected, limit 2); tongue: 5.9 nTPM (protected, limit 2); adipose tissue: 5.2 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162639,HENMT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.156583,-0.127831,-0.147831
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.0759% (minimum 95%, Uncertain); adrenal gland: 96.0165% (minimum 99%, Missing); amygdala: 89.8458% (minimum 99%, Missing); basal ganglia: 87.2659% (minimum 99%, Missing); bone marrow: 84.2169% (minimum 99%, Uncertain); cerebellum: 94.3320% (minimum 99%, Missing); cerebral cortex: 86.0837% (minimum 99%, Missing); choroid plexus: 98.3122% (minimum 99%, Missing); colon: 91.7323% (minimum 97%, Missing); duodenum: 93.5743% (minimum 99%, Missing); esophagus: 96.4138% (minimum 97%, Missing); heart muscle: 97.6257% (minimum 99%, Uncertain); hippocampal formation: 90.4269% (minimum 99%, Missing); hypothalamus: 84.9332% (minimum 99%, Missing); kidney: 95.4918% (minimum 99%, Missing); liver: 97.3538% (minimum 99%, Uncertain); lung: 93.8255% (minimum 99%, Missing); lymph node: 84.2169% (minimum 97%, Missing); midbrain: 87.8141% (minimum 99%, Missing); pancreas: 97.2184% (minimum 99%, Missing); pituitary gland: 93.2000% (minimum 99%, Missing); rectum: 88.3692% (minimum 97%, Missing); retina: 96.0165% (minimum 99%, Missing); salivary gland: 96.0165% (minimum 97%, Missing); skeletal muscle: 95.7534% (minimum 99%, Missing); skin: 94.9728% (minimum 95%, Missing); small intestine: 90.4269% (minimum 99%, Missing); smooth muscle: 95.3615% (minimum 99%, Missing); spinal cord: 88.2576% (minimum 99%, Missing); spleen: 86.6171% (minimum 95%, Missing); stomach: 93.8255% (minimum 97%, Missing); thymus: 79.3417% (minimum 95%, Missing); tongue: 92.2164% (minimum 97%, Missing); urinary bladder: 92.0949% (minimum 97%, Missing)",0,2,partial,13.1,13.1,18.2,"thymus: 18.2 nTPM (manageable, limit 5); lymph node: 13.1 nTPM (protected, limit 2); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); spleen: 10.8 nTPM (manageable, limit 5); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 2); amygdala: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); urinary bladder: 6 nTPM (protected, limit 2); tongue: 5.9 nTPM (protected, limit 2); adipose tissue: 5.2 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); esophagus: 2.6 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162639,HENMT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.156583,-0.127831,-0.147831
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000162641,AKNAD1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 94.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000162641,AKNAD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,-0.01,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 94.0000% (minimum 95%, Missing)",0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000162641,AKNAD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,-0.01,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,10,partial,0.8,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000162753,SLC9C2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.3051% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.8788% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.3051% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.3051% (minimum 99%, Baseline (adaptation disabled)); retina: 95.0820% (minimum 99%, Baseline (adaptation disabled))",0,10,partial,0.8,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000162753,SLC9C2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0166667,0.0130508,-0.111212
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.3051% (minimum 99%, Missing); choroid plexus: 87.8788% (minimum 99%, Missing); hippocampal formation: 98.3051% (minimum 99%, Missing); pituitary gland: 98.3051% (minimum 99%, Missing); retina: 95.0820% (minimum 99%, Missing)",0,10,partial,0.8,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000162753,SLC9C2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.111212
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3,3.9,0,"parathyroid gland: 3.9 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000162763,LRRC52,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 84.3750% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.5904% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5904% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.5970% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.7805% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 92.5714% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3,3.9,0,"parathyroid gland: 3.9 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000162763,LRRC52,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,-0.16403,-0.14625
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 84.3750% (minimum 99%, Missing); heart muscle: 97.5904% (minimum 99%, Missing); kidney: 97.5904% (minimum 99%, Missing); parathyroid gland: 80.5970% (minimum 97%, Missing); pituitary gland: 98.7805% (minimum 99%, Missing); skeletal muscle: 92.5714% (minimum 99%, Missing)",0,80,unavailable,3,3.9,0,"parathyroid gland: 3.9 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000162763,LRRC52,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,-0.16403,-0.14625
True,compatible,,True,True,False,,0,4,partial,0.4,0.3,0.7,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,ENSG00000162771,GARIN4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0.4,0.3,0.7,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,ENSG00000162771,GARIN4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0409326,0.0260938,0.00479844
True,compatible,,True,True,True,,0,4,partial,0.4,0.3,0.7,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,ENSG00000162771,GARIN4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0486945,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,3,partial,0.3,0.2,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000162779,AXDND1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.0769% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.0769% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7097% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.3,0.2,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000162779,AXDND1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,0.0435065,0.0170968,-0.00923077
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 98.0769% (minimum 99%, Missing); retina: 98.7097% (minimum 99%, Missing)",0,3,partial,0.3,0.2,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000162779,AXDND1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,-0.00923077
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,2.3,0.8,0.8,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus; tonsil,ENSG00000162782,TDRD5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.8037% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.2128% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6047% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.2477% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.6959% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6959% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.9276% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.1739% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.2477% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.5983% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.8037% (minimum 97%, Baseline (adaptation disabled)); retina: 98.6047% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.3636% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.1481% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,2.3,0.8,0.8,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus; tonsil,ENSG00000162782,TDRD5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0136364,-0.00636364,-0.0878723
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.8037% (minimum 99%, Missing); basal ganglia: 90.2128% (minimum 99%, Missing); hippocampal formation: 97.6959% (minimum 99%, Missing); hypothalamus: 95.9276% (minimum 99%, Missing); kidney: 92.1739% (minimum 99%, Missing); midbrain: 97.2477% (minimum 99%, Missing); pituitary gland: 90.5983% (minimum 99%, Missing); retina: 98.6047% (minimum 99%, Missing)",0,4,partial,2.3,0.8,0.8,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus; tonsil,ENSG00000162782,TDRD5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0453052,0.03,-0.0878723
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,2.7,2.5,0.7,"choroid plexus: 2.7 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162814,SPATA17,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.0198% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.0588% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.1923% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.3448% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.0588% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.5714% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.0588% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.1165% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.2857% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.3962% (minimum 99%, Baseline (adaptation disabled)); lung: 95.1923% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.0588% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.8387% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.1165% (minimum 99%, Baseline (adaptation disabled)); retina: 86.0870% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 83.1933% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.1165% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 93.3962% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,2.7,2.5,0.7,"choroid plexus: 2.7 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162814,SPATA17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,-0.0160377,-0.171613,-0.204286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.0588% (minimum 99%, Missing); basal ganglia: 95.1923% (minimum 99%, Missing); bone marrow: 85.3448% (minimum 95%, Enhanced); choroid plexus: 78.5714% (minimum 99%, Missing); hippocampal formation: 96.1165% (minimum 99%, Missing); hypothalamus: 94.2857% (minimum 99%, Missing); kidney: 93.3962% (minimum 99%, Missing); parathyroid gland: 79.8387% (minimum 97%, Missing); pituitary gland: 96.1165% (minimum 99%, Missing); retina: 86.0870% (minimum 99%, Missing); skeletal muscle: 83.1933% (minimum 95%, Enhanced)",0,6,partial,2.7,2.5,0.7,"choroid plexus: 2.7 nTPM (vital, limit 1); parathyroid gland: 2.5 nTPM (protected, limit 2); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162814,SPATA17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,0.04,-0.171613,-0.204286
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000162843,WDR64,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 95.8333% (minimum 99%, Baseline (adaptation disabled)); duodenum: 95.8333% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.8333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000162843,WDR64,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.0316667
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 95.8333% (minimum 99%, Missing); duodenum: 95.8333% (minimum 99%, Missing); small intestine: 95.8333% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000162843,WDR64,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.0316667
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,30.7,37.4,13.9,"tongue: 37.4 nTPM (protected, limit 2); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 2); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); thymus: 13.9 nTPM (manageable, limit 5); thyroid gland: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 2); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 2); parathyroid gland: 10.9 nTPM (protected, limit 2); urinary bladder: 10.9 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); skin: 9.9 nTPM (manageable, limit 5); duodenum: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 2); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 4); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000162852,CNST,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.8008% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 40.0641% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.5676% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.4112% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 35.0140% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 42.5170% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 44.6429% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 48.8281% (minimum 99%, Baseline (adaptation disabled)); colon: 48.4496% (minimum 97%, Baseline (adaptation disabled)); duodenum: 55.8036% (minimum 99%, Baseline (adaptation disabled)); esophagus: 43.7063% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.5238% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 66.4894% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 51.8672% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.0962% (minimum 99%, Baseline (adaptation disabled)); liver: 35.4108% (minimum 99%, Baseline (adaptation disabled)); lung: 56.5611% (minimum 99%, Baseline (adaptation disabled)); lymph node: 43.4028% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.4518% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.8036% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 53.4188% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.1313% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.8672% (minimum 97%, Baseline (adaptation disabled)); retina: 43.5540% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.1026% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 28.9352% (minimum 99%, Baseline (adaptation disabled)); skin: 55.8036% (minimum 95%, Baseline (adaptation disabled)); small intestine: 49.4071% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.3063% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.0227% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.0661% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.3865% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.3485% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.0769% (minimum 95%, Baseline (adaptation disabled)); tongue: 25.0501% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.4188% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,30.7,37.4,13.9,"tongue: 37.4 nTPM (protected, limit 2); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 2); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); thymus: 13.9 nTPM (manageable, limit 5); thyroid gland: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 2); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 2); parathyroid gland: 10.9 nTPM (protected, limit 2); urinary bladder: 10.9 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); skin: 9.9 nTPM (manageable, limit 5); duodenum: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 2); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 2); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000162852,CNST,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.476515,-0.719499,-0.700648
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.8008% (minimum 95%, Missing); adrenal gland: 40.0641% (minimum 99%, Missing); amygdala: 67.5676% (minimum 99%, Missing); basal ganglia: 58.4112% (minimum 99%, Missing); bone marrow: 35.0140% (minimum 99%, Missing); cerebellum: 42.5170% (minimum 99%, Missing); cerebral cortex: 44.6429% (minimum 99%, Missing); choroid plexus: 48.8281% (minimum 99%, Missing); colon: 48.4496% (minimum 97%, Missing); duodenum: 55.8036% (minimum 99%, Missing); esophagus: 43.7063% (minimum 97%, Missing); heart muscle: 59.5238% (minimum 99%, Missing); hippocampal formation: 66.4894% (minimum 99%, Missing); hypothalamus: 51.8672% (minimum 99%, Missing); kidney: 60.0962% (minimum 99%, Missing); liver: 35.4108% (minimum 99%, Missing); lung: 56.5611% (minimum 99%, Missing); lymph node: 43.4028% (minimum 97%, Missing); midbrain: 63.4518% (minimum 99%, Missing); pancreas: 55.8036% (minimum 99%, Missing); parathyroid gland: 53.4188% (minimum 97%, Missing); pituitary gland: 63.1313% (minimum 99%, Missing); rectum: 51.8672% (minimum 97%, Missing); retina: 43.5540% (minimum 99%, Missing); salivary gland: 64.1026% (minimum 95%, Approved); skeletal muscle: 28.9352% (minimum 99%, Missing); skin: 55.8036% (minimum 95%, Missing); small intestine: 49.4071% (minimum 99%, Missing); smooth muscle: 56.3063% (minimum 99%, Missing); spinal cord: 71.0227% (minimum 99%, Missing); spleen: 55.0661% (minimum 95%, Missing); stomach: 60.3865% (minimum 97%, Missing); thymus: 47.3485% (minimum 95%, Missing); thyroid gland: 48.0769% (minimum 95%, Missing); tongue: 25.0501% (minimum 97%, Missing); urinary bladder: 53.4188% (minimum 97%, Missing)",0,2,partial,30.7,37.4,13.9,"tongue: 37.4 nTPM (protected, limit 2); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 2); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); thymus: 13.9 nTPM (manageable, limit 5); thyroid gland: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 2); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 2); parathyroid gland: 10.9 nTPM (protected, limit 2); urinary bladder: 10.9 nTPM (protected, limit 2); spleen: 10.2 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); skin: 9.9 nTPM (manageable, limit 5); duodenum: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 2); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 4); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000162852,CNST,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.476515,-0.719499,-0.700648
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,24.3,13.3,13.3,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 2); thyroid gland: 13.3 nTPM (manageable, limit 5); tongue: 13.1 nTPM (protected, limit 2); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 2); colon: 9.9 nTPM (protected, limit 2); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); stomach: 9.8 nTPM (protected, limit 2); small intestine: 9.5 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 2); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); hippocampal formation: 6.6 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162928,PEX13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.1814% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.0224% (minimum 99%, Baseline (adaptation disabled)); amygdala: 66.5138% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 67.4419% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.5138% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.7317% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.7204% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.9091% (minimum 99%, Baseline (adaptation disabled)); colon: 59.4262% (minimum 97%, Baseline (adaptation disabled)); duodenum: 59.4262% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.4262% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 55.7692% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.7204% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.4419% (minimum 99%, Baseline (adaptation disabled)); kidney: 52.5362% (minimum 99%, Baseline (adaptation disabled)); liver: 37.3711% (minimum 99%, Baseline (adaptation disabled)); lung: 61.7021% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.7204% (minimum 97%, Baseline (adaptation disabled)); midbrain: 67.7570% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.9846% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.1814% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.8203% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.4677% (minimum 97%, Baseline (adaptation disabled)); retina: 63.0435% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.3188% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.6993% (minimum 99%, Baseline (adaptation disabled)); skin: 65.6109% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.4167% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.0224% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.3153% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.0476% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.6708% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.8203% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.1583% (minimum 95%, Baseline (adaptation disabled)); tongue: 52.5362% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.1583% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,24.3,13.3,13.3,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 2); thyroid gland: 13.3 nTPM (manageable, limit 5); tongue: 13.1 nTPM (protected, limit 2); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 2); colon: 9.9 nTPM (protected, limit 2); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); stomach: 9.8 nTPM (protected, limit 2); small intestine: 9.5 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 2); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); hippocampal formation: 6.6 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162928,PEX13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.428417,-0.448417,-0.616289
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.1814% (minimum 95%, Missing); adrenal gland: 65.0224% (minimum 99%, Missing); amygdala: 66.5138% (minimum 99%, Missing); basal ganglia: 67.4419% (minimum 99%, Missing); bone marrow: 66.5138% (minimum 99%, Missing); cerebellum: 70.7317% (minimum 99%, Missing); cerebral cortex: 68.7204% (minimum 99%, Missing); choroid plexus: 65.9091% (minimum 99%, Missing); colon: 59.4262% (minimum 97%, Missing); duodenum: 59.4262% (minimum 99%, Missing); esophagus: 59.4262% (minimum 97%, Missing); heart muscle: 55.7692% (minimum 99%, Missing); hippocampal formation: 68.7204% (minimum 99%, Missing); hypothalamus: 67.4419% (minimum 99%, Missing); kidney: 52.5362% (minimum 99%, Missing); liver: 37.3711% (minimum 99%, Missing); lung: 61.7021% (minimum 99%, Missing); lymph node: 68.7204% (minimum 97%, Missing); midbrain: 67.7570% (minimum 99%, Missing); pancreas: 55.9846% (minimum 99%, Missing); parathyroid gland: 61.1814% (minimum 97%, Missing); pituitary gland: 66.8203% (minimum 99%, Missing); rectum: 58.4677% (minimum 97%, Missing); retina: 63.0435% (minimum 99%, Missing); salivary gland: 63.3188% (minimum 97%, Missing); skeletal muscle: 50.6993% (minimum 99%, Missing); skin: 65.6109% (minimum 95%, Missing); small intestine: 60.4167% (minimum 99%, Missing); smooth muscle: 65.0224% (minimum 99%, Missing); spinal cord: 65.3153% (minimum 99%, Missing); spleen: 69.0476% (minimum 95%, Missing); stomach: 59.6708% (minimum 97%, Missing); thymus: 66.8203% (minimum 95%, Missing); thyroid gland: 52.1583% (minimum 95%, Missing); tongue: 52.5362% (minimum 97%, Missing); urinary bladder: 52.1583% (minimum 97%, Missing)",0,5,partial,24.3,13.3,13.3,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 2); thyroid gland: 13.3 nTPM (manageable, limit 5); tongue: 13.1 nTPM (protected, limit 2); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 2); colon: 9.9 nTPM (protected, limit 2); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 2); stomach: 9.8 nTPM (protected, limit 2); small intestine: 9.5 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 2); adipose tissue: 9.2 nTPM (manageable, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 2); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 2); hippocampal formation: 6.6 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162928,PEX13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.428417,-0.448417,-0.616289
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,46.1,4.5,6.3,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000162931,TRIM17,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.1429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.2779% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.0718% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 46.9505% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.9875% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.5504% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.5504% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.0957% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.7419% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.3638% (minimum 99%, Baseline (adaptation disabled)); lung: 96.6825% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.3747% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.5507% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.4539% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.1049% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.0662% (minimum 97%, Baseline (adaptation disabled)); small intestine: 97.6077% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.2264% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.6242% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.9385% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.2264% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,46.1,4.5,6.3,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); spleen: 6.3 nTPM (manageable, limit 5); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000162931,TRIM17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.083758,-0.0693377,-0.520495
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 97.1429% (minimum 99%, Missing); amygdala: 89.2779% (minimum 99%, Missing); basal ganglia: 65.0718% (minimum 99%, Missing); cerebellum: 46.9505% (minimum 99%, Missing); cerebral cortex: 72.9875% (minimum 99%, Missing); choroid plexus: 95.5504% (minimum 99%, Missing); esophagus: 95.5504% (minimum 97%, Missing); heart muscle: 96.0000% (minimum 99%, Missing); hippocampal formation: 83.0957% (minimum 99%, Missing); hypothalamus: 87.7419% (minimum 99%, Missing); kidney: 93.3638% (minimum 99%, Missing); lung: 96.6825% (minimum 99%, Missing); midbrain: 97.3747% (minimum 99%, Missing); pancreas: 98.5507% (minimum 99%, Missing); pituitary gland: 95.1049% (minimum 99%, Missing); salivary gland: 90.0662% (minimum 97%, Missing); small intestine: 97.6077% (minimum 99%, Missing); spinal cord: 96.2264% (minimum 99%, Missing); spleen: 86.6242% (minimum 90%, Approved); thyroid gland: 92.9385% (minimum 95%, Missing); urinary bladder: 96.2264% (minimum 97%, Missing)",0,5,partial,46.1,4.5,6.3,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000162931,TRIM17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.033758,-0.0693377,-0.520495
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.5,5.2,4.9,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 2); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162994,CLHC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.9048% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.3931% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.6832% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.9518% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 87.4251% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.3905% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.3801% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.6596% (minimum 99%, Baseline (adaptation disabled)); colon: 84.3931% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.9518% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.3801% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.3905% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.0244% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.9518% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.6630% (minimum 99%, Baseline (adaptation disabled)); liver: 90.1235% (minimum 99%, Baseline (adaptation disabled)); lung: 85.8824% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.9080% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.6832% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.3801% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.7374% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.9212% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.9545% (minimum 97%, Baseline (adaptation disabled)); retina: 66.0633% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 84.3931% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.5706% (minimum 99%, Baseline (adaptation disabled)); skin: 74.8718% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.3931% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.5642% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.4848% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.1111% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.8824% (minimum 97%, Baseline (adaptation disabled)); thymus: 78.4946% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 79.3478% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.5897% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.9080% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7.5,5.2,4.9,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 2); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162994,CLHC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.201282,-0.232626,-0.329367
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.9048% (minimum 95%, Missing); adrenal gland: 84.3931% (minimum 99%, Missing); amygdala: 90.6832% (minimum 99%, Missing); basal ganglia: 87.9518% (minimum 99%, Missing); bone marrow: 87.4251% (minimum 99%, Missing); cerebellum: 86.3905% (minimum 99%, Missing); cerebral cortex: 85.3801% (minimum 99%, Missing); choroid plexus: 77.6596% (minimum 99%, Missing); colon: 84.3931% (minimum 97%, Missing); duodenum: 87.9518% (minimum 99%, Missing); esophagus: 85.3801% (minimum 97%, Missing); heart muscle: 86.3905% (minimum 99%, Missing); hippocampal formation: 89.0244% (minimum 99%, Missing); hypothalamus: 87.9518% (minimum 99%, Missing); kidney: 80.6630% (minimum 99%, Missing); liver: 90.1235% (minimum 99%, Missing); lung: 85.8824% (minimum 99%, Missing); lymph node: 83.9080% (minimum 97%, Missing); midbrain: 90.6832% (minimum 99%, Missing); pancreas: 85.3801% (minimum 99%, Missing); parathyroid gland: 73.7374% (minimum 97%, Missing); pituitary gland: 71.9212% (minimum 99%, Missing); rectum: 82.9545% (minimum 97%, Missing); retina: 66.0633% (minimum 99%, Missing); salivary gland: 84.3931% (minimum 97%, Missing); skeletal muscle: 89.5706% (minimum 99%, Missing); skin: 74.8718% (minimum 95%, Missing); small intestine: 84.3931% (minimum 99%, Missing); smooth muscle: 81.5642% (minimum 99%, Missing); spinal cord: 88.4848% (minimum 99%, Missing); spleen: 81.1111% (minimum 95%, Missing); stomach: 85.8824% (minimum 97%, Missing); thymus: 78.4946% (minimum 95%, Missing); thyroid gland: 79.3478% (minimum 95%, Missing); tongue: 93.5897% (minimum 97%, Missing); urinary bladder: 83.9080% (minimum 97%, Missing)",0,80,unavailable,7.5,5.2,4.9,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 2); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); urinary bladder: 2.8 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000162994,CLHC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.201282,-0.232626,-0.329367
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,3,3.8,1.7,"stomach: 3.8 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 2); basal ganglia: 2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162999,DUSP19,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.2609% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.2857% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.9245% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 72.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.4694% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.4694% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.5455% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.9245% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.7209% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.9245% (minimum 99%, Baseline (adaptation disabled)); liver: 76.5957% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.7209% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.5882% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.5957% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.2609% (minimum 97%, Baseline (adaptation disabled)); retina: 76.5957% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.2308% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.5957% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.7143% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.2308% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.6486% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 67.9245% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.2308% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.5957% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,3,3.8,1.7,"stomach: 3.8 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162999,DUSP19,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.270755,-0.483514,-0.444545
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.2609% (minimum 90%, Approved); adrenal gland: 72.0000% (minimum 99%, Missing); amygdala: 72.0000% (minimum 99%, Missing); basal ganglia: 64.2857% (minimum 99%, Missing); bone marrow: 92.3077% (minimum 98%, Approved); cerebellum: 92.3077% (minimum 98%, Approved); cerebral cortex: 67.9245% (minimum 99%, Missing); choroid plexus: 90.0000% (minimum 99%, Missing); colon: 72.0000% (minimum 97%, Missing); duodenum: 73.4694% (minimum 99%, Missing); esophagus: 73.4694% (minimum 97%, Missing); heart muscle: 54.5455% (minimum 98%, Approved); hippocampal formation: 67.9245% (minimum 99%, Missing); hypothalamus: 83.7209% (minimum 99%, Missing); kidney: 67.9245% (minimum 99%, Missing); liver: 76.5957% (minimum 99%, Missing); lung: 75.0000% (minimum 98%, Approved); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 83.7209% (minimum 99%, Missing); pancreas: 80.0000% (minimum 99%, Missing); parathyroid gland: 70.5882% (minimum 95%, Approved); pituitary gland: 76.5957% (minimum 99%, Missing); rectum: 78.2609% (minimum 97%, Missing); retina: 76.5957% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 95%, Approved); skeletal muscle: 69.2308% (minimum 98%, Approved); skin: 75.0000% (minimum 90%, Approved); small intestine: 76.5957% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 98%, Approved); spinal cord: 85.7143% (minimum 99%, Missing); spleen: 69.2308% (minimum 90%, Approved); stomach: 48.6486% (minimum 97%, Missing); thymus: 75.0000% (minimum 95%, Missing); thyroid gland: 67.9245% (minimum 90%, Approved); tongue: 69.2308% (minimum 97%, Missing); urinary bladder: 76.5957% (minimum 97%, Missing)",0,2,partial,3,3.8,1.7,"stomach: 3.8 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 2); basal ganglia: 2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000162999,DUSP19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.220755,-0.483514,-0.434545
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,3.4,4.3,6.2,"thymus: 6.2 nTPM (manageable, limit 5); bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000163006,CCDC138,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.1739% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.1739% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.1270% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.8852% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.8000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.8053% (minimum 99%, Baseline (adaptation disabled)); colon: 85.4839% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.1739% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.1270% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.8053% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.3030% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.4839% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.8852% (minimum 99%, Baseline (adaptation disabled)); liver: 79.6992% (minimum 99%, Baseline (adaptation disabled)); lung: 89.0756% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.1409% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.8852% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.8852% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.8053% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.9825% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.8125% (minimum 97%, Baseline (adaptation disabled)); retina: 82.8125% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.0756% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.3793% (minimum 99%, Baseline (adaptation disabled)); skin: 82.1705% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.8852% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.6033% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.9160% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.8305% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.4839% (minimum 97%, Baseline (adaptation disabled)); thymus: 63.0952% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.9825% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.6429% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.6033% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,3.4,4.3,6.2,"thymus: 6.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000163006,CCDC138,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.319048,-0.258591,-0.232857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.1739% (minimum 99%, Missing); amygdala: 84.1270% (minimum 99%, Missing); basal ganglia: 86.8852% (minimum 99%, Missing); bone marrow: 75.7143% (minimum 99%, Missing); cerebellum: 84.8000% (minimum 99%, Missing); cerebral cortex: 88.3333% (minimum 99%, Missing); choroid plexus: 93.8053% (minimum 99%, Missing); colon: 85.4839% (minimum 97%, Missing); duodenum: 92.1739% (minimum 99%, Missing); esophagus: 84.1270% (minimum 97%, Missing); heart muscle: 93.8053% (minimum 95%, Enhanced); hippocampal formation: 80.3030% (minimum 99%, Missing); hypothalamus: 85.4839% (minimum 99%, Missing); kidney: 86.8852% (minimum 99%, Missing); liver: 79.6992% (minimum 99%, Missing); lung: 89.0756% (minimum 99%, Missing); lymph node: 71.1409% (minimum 80%, Enhanced); midbrain: 86.8852% (minimum 99%, Missing); pancreas: 86.8852% (minimum 99%, Missing); pituitary gland: 92.9825% (minimum 99%, Missing); rectum: 82.8125% (minimum 97%, Missing); retina: 82.8125% (minimum 99%, Missing); salivary gland: 89.0756% (minimum 97%, Missing); skeletal muscle: 91.3793% (minimum 99%, Missing); skin: 82.1705% (minimum 95%, Missing); small intestine: 86.8852% (minimum 99%, Missing); smooth muscle: 87.6033% (minimum 99%, Missing); spinal cord: 80.9160% (minimum 99%, Missing); stomach: 85.4839% (minimum 97%, Missing); thymus: 63.0952% (minimum 95%, Missing); thyroid gland: 92.9825% (minimum 95%, Missing); tongue: 94.6429% (minimum 97%, Missing); urinary bladder: 87.6033% (minimum 97%, Missing)",0,2,partial,3.4,4.3,6.2,"thymus: 6.2 nTPM (manageable, limit 5); bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000163006,CCDC138,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.319048,-0.141875,-0.232857
True,compatible,,True,True,False,,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000163012,ZSWIM2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.9011% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.8261% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.7500% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000163012,ZSWIM2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.0525
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.9011% (minimum 99%, Missing); hypothalamus: 97.8261% (minimum 99%, Missing); pituitary gland: 93.7500% (minimum 99%, Missing)",0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000163012,ZSWIM2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.0525
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,9,partial,0.6,0,0,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),53,not_established,not_triggered,,,ENSG00000163060,TEKT4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.0370% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.3235% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.4962% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.4962% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.6204% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.6204% (minimum 99%, Baseline (adaptation disabled)); lung: 97.0370% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.4962% (minimum 99%, Baseline (adaptation disabled))",0,9,partial,0.6,0,0,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),53,not_established,not_triggered,,,ENSG00000163060,TEKT4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.0337956
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.0370% (minimum 99%, Missing); basal ganglia: 96.3235% (minimum 99%, Missing); choroid plexus: 98.4962% (minimum 99%, Missing); hippocampal formation: 95.6204% (minimum 99%, Missing); hypothalamus: 95.6204% (minimum 99%, Missing); spinal cord: 98.4962% (minimum 99%, Missing)",0,9,partial,0.6,0,0,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),53,not_established,not_triggered,,,ENSG00000163060,TEKT4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.0337956
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000163114,PDHA2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000163114,PDHA2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000163114,PDHA2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,1.2,0.1,0.2,,,54,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000163206,SMCP,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,2,partial,1.2,0.1,0.2,"cerebellum: 1.2 nTPM (vital, limit 1)",,54,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000163206,SMCP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0497251,0.0298625,0.00835278
True,compatible,,True,True,True,,0,2,partial,1.2,0.1,0.2,,,54,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000163206,SMCP,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00945032
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.8,3.7,10.7,"adipose tissue: 10.7 nTPM (manageable, limit 5); thyroid gland: 10.7 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); small intestine: 3.4 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163239,TDRD10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.4877% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.6370% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.3022% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.9534% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.6534% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.1275% (minimum 99%, Baseline (adaptation disabled)); colon: 95.2465% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.7226% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.7522% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.9675% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6534% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.1851% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.0870% (minimum 99%, Baseline (adaptation disabled)); liver: 92.4786% (minimum 99%, Baseline (adaptation disabled)); lung: 87.3990% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.1275% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.3636% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.5830% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.7800% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.7800% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.0870% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.9534% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.3636% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.1465% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.7800% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 83.4877% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.5986% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7.8,3.7,10.7,"adipose tissue: 10.7 nTPM (manageable, limit 5); thyroid gland: 10.7 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); small intestine: 3.4 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163239,TDRD10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.115123,-0.0340138,-0.11601
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.4877% (minimum 95%, Missing); adrenal gland: 92.6370% (minimum 99%, Missing); amygdala: 97.3022% (minimum 99%, Missing); basal ganglia: 96.9534% (minimum 99%, Missing); cerebral cortex: 97.6534% (minimum 99%, Missing); choroid plexus: 97.1275% (minimum 99%, Missing); colon: 95.2465% (minimum 97%, Missing); duodenum: 98.7226% (minimum 99%, Missing); esophagus: 95.7522% (minimum 97%, Missing); heart muscle: 87.9675% (minimum 99%, Missing); hippocampal formation: 97.6534% (minimum 99%, Missing); hypothalamus: 98.1851% (minimum 99%, Missing); kidney: 94.0870% (minimum 99%, Missing); liver: 92.4786% (minimum 99%, Missing); lung: 87.3990% (minimum 99%, Missing); midbrain: 97.1275% (minimum 99%, Missing); pancreas: 98.3636% (minimum 99%, Missing); pituitary gland: 95.5830% (minimum 99%, Missing); salivary gland: 96.7800% (minimum 97%, Missing); skeletal muscle: 96.7800% (minimum 99%, Missing); small intestine: 94.0870% (minimum 99%, Missing); smooth muscle: 96.9534% (minimum 99%, Missing); spinal cord: 98.3636% (minimum 99%, Missing); spleen: 86.1465% (minimum 95%, Missing); stomach: 96.7800% (minimum 97%, Missing); thyroid gland: 83.4877% (minimum 95%, Missing); urinary bladder: 93.5986% (minimum 97%, Missing)",0,80,unavailable,7.8,3.7,10.7,"adipose tissue: 10.7 nTPM (manageable, limit 5); thyroid gland: 10.7 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); small intestine: 3.4 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163239,TDRD10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.115123,-0.0340138,-0.11601
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: High (Supported),59,not_established,not_triggered,,,ENSG00000163254,CRYGC,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 94.1176% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: High (Supported),59,not_established,not_triggered,,,ENSG00000163254,CRYGC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0488235
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 94.1176% (minimum 99%, Missing)",0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: High (Supported),59,not_established,not_triggered,,,ENSG00000163254,CRYGC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0488235
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,0.4,0.1,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,ENSG00000163263,CFAP141,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.9933% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0066% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.5513% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.0066% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.0395% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9933% (minimum 99%, Baseline (adaptation disabled)); lung: 94.5513% (minimum 99%, Baseline (adaptation disabled)); retina: 98.0066% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.7,0.4,0.1,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,ENSG00000163263,CFAP141,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0466216,0.0166221,-0.0444872
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.9933% (minimum 99%, Missing); basal ganglia: 98.0066% (minimum 99%, Missing); bone marrow: 98.3333% (minimum 99%, Missing); choroid plexus: 94.5513% (minimum 99%, Missing); hippocampal formation: 98.0066% (minimum 99%, Missing); hypothalamus: 97.0395% (minimum 99%, Missing); liver: 98.9933% (minimum 99%, Missing); lung: 94.5513% (minimum 99%, Missing); retina: 98.0066% (minimum 99%, Missing)",0,80,unavailable,1.7,0.4,0.1,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,ENSG00000163263,CFAP141,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0466216,0.0166221,-0.0444872
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,12,partial,3.8,0,0.1,,colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; spleen,ENSG00000163283,ALPP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lung: 89.8396% (minimum 99%, Baseline (adaptation disabled))",0,12,partial,3.8,0,0.1,"lung: 3.8 nTPM (vital, limit 1)",colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; spleen,ENSG00000163283,ALPP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0470326,0.03,-0.0916043
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"lung: 89.8396% (minimum 95%, Enhanced)",0,12,partial,3.8,0,0.1,,colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; spleen,ENSG00000163283,ALPP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.0516043
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,11,partial,0.4,0.1,0.1,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); skin 1 / fibrohistiocytic cells: Low (Approved); small intestine / enterocytes - Microvilli: High (Approved),92,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / fibrohistiocytic cells; thymus,ENSG00000163286,ALPG,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"colon: 90.0000% (minimum 97%, Baseline (adaptation disabled)); lung: 69.2308% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.0000% (minimum 95%, Baseline (adaptation disabled))",0,11,partial,0.4,0.1,0.1,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); skin 1 / fibrohistiocytic cells: Low (Approved); small intestine / enterocytes - Microvilli: High (Approved),92,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / fibrohistiocytic cells; thymus,ENSG00000163286,ALPG,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.05,-0.07,-0.297692
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"colon: 90.0000% (minimum 97%, Missing); lung: 69.2308% (minimum 98%, Approved); rectum: 90.0000% (minimum 97%, Missing); thymus: 90.0000% (minimum 95%, Missing)",0,11,partial,0.4,0.1,0.1,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); skin 1 / fibrohistiocytic cells: Low (Approved); small intestine / enterocytes - Microvilli: High (Approved),92,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / fibrohistiocytic cells; thymus,ENSG00000163286,ALPG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.05,-0.07,-0.287692
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,8.8,9.1,7.8,"lymph node: 9.1 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 2); thymus: 7.8 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); thyroid gland: 5.6 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 4); retina: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); pancreas: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,ENSG00000163312,HELQ,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5042% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 45.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.4194% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.5385% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.5714% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.7895% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 56.6929% (minimum 99%, Baseline (adaptation disabled)); colon: 65.4545% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.9029% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.5714% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.5041% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.2609% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.0645% (minimum 99%, Baseline (adaptation disabled)); liver: 57.6000% (minimum 99%, Baseline (adaptation disabled)); lung: 65.4545% (minimum 99%, Baseline (adaptation disabled)); lymph node: 44.1718% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.2609% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.1429% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.6087% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.4545% (minimum 97%, Baseline (adaptation disabled)); retina: 57.6000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.5385% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 51.0638% (minimum 99%, Baseline (adaptation disabled)); skin: 65.4545% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.6087% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.1579% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.7895% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.1353% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.2500% (minimum 95%, Baseline (adaptation disabled)); tongue: 48.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.1579% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,8.8,9.1,7.8,"lymph node: 9.1 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 2); thymus: 7.8 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); thyroid gland: 5.6 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 2); retina: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); pancreas: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,ENSG00000163312,HELQ,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.47,-0.528282,-0.54
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5042% (minimum 95%, Missing); adrenal gland: 45.0000% (minimum 99%, Missing); amygdala: 80.0000% (minimum 99%, Missing); basal ganglia: 77.4194% (minimum 99%, Missing); bone marrow: 61.5385% (minimum 99%, Missing); cerebellum: 68.5714% (minimum 99%, Missing); cerebral cortex: 75.7895% (minimum 99%, Missing); choroid plexus: 56.6929% (minimum 99%, Missing); colon: 65.4545% (minimum 97%, Missing); duodenum: 69.9029% (minimum 99%, Missing); esophagus: 68.5714% (minimum 97%, Missing); heart muscle: 59.5041% (minimum 99%, Missing); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 78.2609% (minimum 99%, Missing); kidney: 58.0645% (minimum 99%, Missing); liver: 57.6000% (minimum 99%, Missing); lung: 65.4545% (minimum 99%, Missing); lymph node: 44.1718% (minimum 97%, Missing); midbrain: 78.2609% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 57.1429% (minimum 95%, Approved); pituitary gland: 62.6087% (minimum 99%, Missing); rectum: 65.4545% (minimum 97%, Missing); retina: 57.6000% (minimum 99%, Missing); salivary gland: 61.5385% (minimum 97%, Missing); skeletal muscle: 51.0638% (minimum 99%, Missing); skin: 65.4545% (minimum 95%, Missing); small intestine: 62.6087% (minimum 99%, Missing); smooth muscle: 63.1579% (minimum 99%, Missing); spinal cord: 75.7895% (minimum 99%, Missing); spleen: 54.1353% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Missing); thymus: 48.0000% (minimum 95%, Missing); thyroid gland: 56.2500% (minimum 95%, Missing); tongue: 48.0000% (minimum 97%, Missing); urinary bladder: 63.1579% (minimum 97%, Missing)",0,3,partial,8.8,9.1,7.8,"lymph node: 9.1 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 2); thymus: 7.8 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); thyroid gland: 5.6 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 4); retina: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); pancreas: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,ENSG00000163312,HELQ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.47,-0.528282,-0.54
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,7.6,7.8,7.2,"lymph node: 7.8 nTPM (protected, limit 2); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); esophagus: 5 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000163322,ABRAXAS1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.4266% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.3043% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.3043% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 58.0110% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.9204% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.6774% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 77.2059% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 67.7419% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.4681% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.3043% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.5172% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.9167% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 74.4681% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.3770% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.5172% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.0870% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.5172% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.5455% (minimum 97%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.0870% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.8743% (minimum 99%, Baseline (adaptation disabled)); skin: 66.0377% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.7778% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.9474% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.2353% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.4138% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.0789% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.3220% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.6774% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.9437% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,7.6,7.8,7.2,"lymph node: 7.8 nTPM (protected, limit 2); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); esophagus: 5 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000163322,ABRAXAS1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.35678,-0.39623,-0.40989
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Uncertain); adrenal gland: 73.4266% (minimum 99%, Missing); amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 91.3043% (minimum 99%, Missing); bone marrow: 58.0110% (minimum 99%, Uncertain); cerebellum: 92.9204% (minimum 99%, Uncertain); cerebral cortex: 84.6774% (minimum 99%, Uncertain); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 77.2059% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Uncertain); esophagus: 67.7419% (minimum 97%, Uncertain); heart muscle: 74.4681% (minimum 99%, Uncertain); hippocampal formation: 91.3043% (minimum 99%, Missing); hypothalamus: 90.5172% (minimum 99%, Missing); kidney: 72.9167% (minimum 99%, Uncertain); liver: 83.3333% (minimum 99%, Uncertain); lung: 74.4681% (minimum 99%, Uncertain); lymph node: 57.3770% (minimum 97%, Uncertain); midbrain: 90.5172% (minimum 99%, Missing); pancreas: 76.0870% (minimum 99%, Uncertain); parathyroid gland: 83.3333% (minimum 97%, Uncertain); pituitary gland: 90.5172% (minimum 99%, Missing); rectum: 79.5455% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); salivary gland: 76.0870% (minimum 97%, Uncertain); skeletal muscle: 62.8743% (minimum 99%, Uncertain); skin: 66.0377% (minimum 95%, Uncertain); small intestine: 77.7778% (minimum 99%, Missing); smooth muscle: 78.9474% (minimum 99%, Uncertain); spinal cord: 88.2353% (minimum 99%, Missing); spleen: 72.4138% (minimum 95%, Uncertain); stomach: 75.0000% (minimum 97%, Missing); thymus: 69.0789% (minimum 95%, Missing); thyroid gland: 59.3220% (minimum 95%, Uncertain); tongue: 84.6774% (minimum 97%, Missing); urinary bladder: 73.9437% (minimum 97%, Uncertain)",0,3,partial,7.6,7.8,7.2,"lymph node: 7.8 nTPM (protected, limit 2); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); esophagus: 5 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); lung: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 2); pancreas: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000163322,ABRAXAS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.35678,-0.39623,-0.40989
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.5,0.3,3,"retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000163357,DCST1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4848% (minimum 99%, Baseline (adaptation disabled)); duodenum: 89.0411% (minimum 99%, Baseline (adaptation disabled)); retina: 72.2222% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.5882% (minimum 97%, Baseline (adaptation disabled)); skin: 68.4211% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.0411% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.5,0.3,3,"retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000163357,DCST1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.265789,-0.0141176,-0.267778
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4848% (minimum 99%, Missing); duodenum: 89.0411% (minimum 99%, Missing); retina: 72.2222% (minimum 99%, Missing); salivary gland: 95.5882% (minimum 97%, Missing); skin: 68.4211% (minimum 95%, Missing); small intestine: 89.0411% (minimum 99%, Missing)",0,80,unavailable,2.5,0.3,3,"retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000163357,DCST1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.265789,-0.0141176,-0.267778
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,13.7,19.9,5.6,"lymph node: 19.9 nTPM (protected, limit 2); bone marrow: 13.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163376,KBTBD8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 84.4444% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.3563% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.6829% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.3563% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 35.6808% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.3636% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.3636% (minimum 99%, Baseline (adaptation disabled)); colon: 76.7677% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.7204% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.3933% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.2566% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.5663% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.4762% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.6829% (minimum 99%, Baseline (adaptation disabled)); liver: 85.3933% (minimum 99%, Baseline (adaptation disabled)); lung: 78.3505% (minimum 99%, Baseline (adaptation disabled)); lymph node: 27.6364% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.5663% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.4118% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.2025% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.8272% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 86.3636% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.4762% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.5165% (minimum 99%, Baseline (adaptation disabled)); skin: 93.8272% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.7864% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.3563% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.5663% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.5758% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.3505% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.4685% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.4762% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.3505% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.8511% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,13.7,19.9,5.6,"lymph node: 19.9 nTPM (protected, limit 2); bone marrow: 13.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); stomach: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163376,KBTBD8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.374242,-0.693636,-0.633192
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 84.4444% (minimum 90%, Approved); adrenal gland: 87.3563% (minimum 99%, Missing); amygdala: 92.6829% (minimum 99%, Missing); basal ganglia: 87.3563% (minimum 99%, Missing); bone marrow: 35.6808% (minimum 99%, Missing); cerebellum: 86.3636% (minimum 99%, Missing); cerebral cortex: 80.0000% (minimum 98%, Approved); choroid plexus: 86.3636% (minimum 99%, Missing); colon: 76.7677% (minimum 97%, Missing); duodenum: 81.7204% (minimum 99%, Missing); esophagus: 85.3933% (minimum 95%, Approved); heart muscle: 67.2566% (minimum 99%, Missing); hippocampal formation: 91.5663% (minimum 99%, Missing); hypothalamus: 90.4762% (minimum 99%, Missing); kidney: 92.6829% (minimum 99%, Missing); liver: 85.3933% (minimum 98%, Approved); lung: 78.3505% (minimum 99%, Missing); lymph node: 27.6364% (minimum 97%, Missing); midbrain: 91.5663% (minimum 99%, Missing); pancreas: 89.4118% (minimum 98%, Approved); parathyroid gland: 96.2025% (minimum 97%, Missing); pituitary gland: 93.8272% (minimum 99%, Missing); rectum: 80.0000% (minimum 97%, Missing); retina: 86.3636% (minimum 99%, Missing); salivary gland: 90.4762% (minimum 97%, Missing); skeletal muscle: 83.5165% (minimum 98%, Approved); skin: 93.8272% (minimum 95%, Missing); small intestine: 73.7864% (minimum 99%, Missing); smooth muscle: 87.3563% (minimum 98%, Approved); spinal cord: 91.5663% (minimum 99%, Missing); spleen: 57.5758% (minimum 95%, Missing); stomach: 78.3505% (minimum 97%, Missing); thymus: 68.4685% (minimum 95%, Missing); thyroid gland: 90.4762% (minimum 95%, Missing); tongue: 78.3505% (minimum 97%, Missing); urinary bladder: 80.8511% (minimum 95%, Approved)",0,0,routine_complete,13.7,19.9,5.6,"lymph node: 19.9 nTPM (protected, limit 2); bone marrow: 13.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163376,KBTBD8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.374242,-0.693636,-0.633192
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,63.7,5.8,21.9,"bone marrow: 63.7 nTPM (vital, limit 2); spleen: 21.9 nTPM (manageable, limit 10); lung: 12.7 nTPM (vital, limit 2); urinary bladder: 5.8 nTPM (protected, limit 4); tongue: 4.1 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163421,PROK2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3260% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.2301% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.6897% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.0678% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 14.8396% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2301% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.5217% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.2773% (minimum 99%, Baseline (adaptation disabled)); colon: 96.5217% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.3684% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.5217% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.7355% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.6897% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.0678% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.8718% (minimum 99%, Baseline (adaptation disabled)); liver: 82.2222% (minimum 99%, Baseline (adaptation disabled)); lung: 46.6387% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.0678% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.9836% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.5217% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.6897% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.6897% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.8000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.5217% (minimum 99%, Baseline (adaptation disabled)); spleen: 33.6364% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.8718% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.7355% (minimum 95%, Baseline (adaptation disabled)); tongue: 73.0263% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.6805% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,63.7,5.8,21.9,"bone marrow: 63.7 nTPM (vital, limit 1); spleen: 21.9 nTPM (manageable, limit 5); lung: 12.7 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); urinary bladder: 5.8 nTPM (protected, limit 2); tongue: 4.1 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163421,PROK2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.613636,-0.313195,-0.841604
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3260% (minimum 90%, Approved); amygdala: 95.6897% (minimum 99%, Missing); basal ganglia: 94.0678% (minimum 99%, Missing); bone marrow: 14.8396% (minimum 98%, Approved); cerebral cortex: 96.5217% (minimum 98%, Approved); choroid plexus: 93.2773% (minimum 99%, Missing); duodenum: 97.3684% (minimum 98%, Approved); heart muscle: 91.7355% (minimum 98%, Approved); hippocampal formation: 95.6897% (minimum 99%, Missing); hypothalamus: 94.0678% (minimum 99%, Missing); kidney: 94.8718% (minimum 98%, Approved); liver: 82.2222% (minimum 98%, Approved); lung: 46.6387% (minimum 98%, Approved); midbrain: 94.0678% (minimum 99%, Missing); pancreas: 90.9836% (minimum 99%, Missing); pituitary gland: 96.5217% (minimum 99%, Missing); skeletal muscle: 95.6897% (minimum 98%, Approved); small intestine: 95.6897% (minimum 98%, Approved); smooth muscle: 88.8000% (minimum 98%, Approved); spinal cord: 96.5217% (minimum 99%, Missing); spleen: 33.6364% (minimum 90%, Approved); stomach: 94.8718% (minimum 95%, Approved); thymus: 91.7355% (minimum 95%, Missing); tongue: 73.0263% (minimum 97%, Missing); urinary bladder: 65.6805% (minimum 95%, Approved)",0,3,partial,63.7,5.8,21.9,"bone marrow: 63.7 nTPM (vital, limit 2); spleen: 21.9 nTPM (manageable, limit 10); lung: 12.7 nTPM (vital, limit 2); urinary bladder: 5.8 nTPM (protected, limit 4); tongue: 4.1 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163421,PROK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.563636,-0.293195,-0.831604
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,2,partial,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced),53,not_established,not_triggered,,,ENSG00000163424,TEX55,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced),53,not_established,not_triggered,,,ENSG00000163424,TEX55,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00808795
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced),53,not_established,not_triggered,,,ENSG00000163424,TEX55,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0.1,0.3,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000163440,PDCL2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0.3,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000163440,PDCL2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0468504,0.025283,0.00842271
True,compatible,,True,True,True,,0,1,partial,0.1,0.3,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000163440,PDCL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.00842271
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.2,1,1,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163467,TSACC,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,2.2,1,1,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163467,TSACC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0488891,0.0288891,0.00755935
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,2.2,1,1,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163467,TSACC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0488891,0.0288891,0.00755935
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.4,14.1,0.5,"tongue: 14.1 nTPM (protected, limit 2); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163491,NEK10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.8101% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.7112% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.8473% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.4904% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.7027% (minimum 99%, Baseline (adaptation disabled)); colon: 94.7514% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.0139% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.3483% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.7112% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.9539% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.2043% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.5432% (minimum 99%, Baseline (adaptation disabled)); liver: 94.7514% (minimum 99%, Baseline (adaptation disabled)); lung: 93.9726% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.5632% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.5632% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.2234% (minimum 99%, Baseline (adaptation disabled)); retina: 88.1748% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 78.4897% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.7208% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5632% (minimum 99%, Baseline (adaptation disabled)); tongue: 70.8678% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.8927% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.4,14.1,0.5,"tongue: 14.1 nTPM (protected, limit 2); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163491,NEK10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0356322,-0.261322,-0.205103
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.8101% (minimum 99%, Missing); basal ganglia: 91.7112% (minimum 99%, Missing); cerebellum: 98.8473% (minimum 99%, Missing); cerebral cortex: 94.4904% (minimum 99%, Missing); choroid plexus: 92.7027% (minimum 99%, Missing); colon: 94.7514% (minimum 97%, Missing); duodenum: 95.0139% (minimum 99%, Missing); esophagus: 96.3483% (minimum 97%, Missing); heart muscle: 91.7112% (minimum 99%, Missing); hippocampal formation: 92.9539% (minimum 99%, Missing); hypothalamus: 92.2043% (minimum 99%, Missing); kidney: 95.5432% (minimum 99%, Missing); liver: 94.7514% (minimum 99%, Missing); lung: 93.9726% (minimum 99%, Missing); midbrain: 98.5632% (minimum 99%, Missing); pancreas: 98.5632% (minimum 99%, Missing); pituitary gland: 91.2234% (minimum 99%, Missing); retina: 88.1748% (minimum 99%, Missing); skeletal muscle: 78.4897% (minimum 99%, Missing); small intestine: 97.7208% (minimum 99%, Missing); spinal cord: 98.5632% (minimum 99%, Missing); tongue: 70.8678% (minimum 97%, Missing); urinary bladder: 96.8927% (minimum 97%, Missing)",0,80,unavailable,9.4,14.1,0.5,"tongue: 14.1 nTPM (protected, limit 2); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163491,NEK10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0356322,-0.261322,-0.205103
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,3.9,3.7,3.2,"bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163507,CIP2A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 77.4194% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.8889% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.0952% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 68.5714% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.5882% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.5714% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.4194% (minimum 99%, Baseline (adaptation disabled)); liver: 88.8889% (minimum 99%, Baseline (adaptation disabled)); lung: 72.7273% (minimum 99%, Baseline (adaptation disabled)); lymph node: 39.3443% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.3077% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.8889% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.7143% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 63.1579% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.8889% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); skin: 70.5882% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.5714% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.7273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.8649% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.4194% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.8571% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 72.7273% (minimum 95%, Baseline (adaptation disabled)); tongue: 85.7143% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,3.9,3.7,3.2,"bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163507,CIP2A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.521429,-0.576557,-0.609048
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 77.4194% (minimum 99%, Missing); amygdala: 88.8889% (minimum 99%, Missing); basal ganglia: 80.0000% (minimum 99%, Missing); bone marrow: 38.0952% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); cerebral cortex: 68.5714% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 68.5714% (minimum 97%, Missing); duodenum: 70.5882% (minimum 99%, Missing); esophagus: 68.5714% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 85.7143% (minimum 99%, Missing); hypothalamus: 85.7143% (minimum 99%, Missing); kidney: 77.4194% (minimum 99%, Missing); liver: 88.8889% (minimum 99%, Missing); lung: 72.7273% (minimum 99%, Missing); lymph node: 39.3443% (minimum 97%, Missing); midbrain: 92.3077% (minimum 99%, Missing); pancreas: 88.8889% (minimum 99%, Missing); parathyroid gland: 85.7143% (minimum 97%, Missing); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 60.0000% (minimum 97%, Missing); retina: 63.1579% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); skeletal muscle: 88.8889% (minimum 99%, Missing); skin: 70.5882% (minimum 95%, Missing); small intestine: 68.5714% (minimum 99%, Missing); smooth muscle: 72.7273% (minimum 99%, Missing); spinal cord: 88.8889% (minimum 99%, Missing); spleen: 64.8649% (minimum 90%, Approved); stomach: 77.4194% (minimum 97%, Missing); thymus: 42.8571% (minimum 95%, Missing); thyroid gland: 72.7273% (minimum 95%, Missing); tongue: 85.7143% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,4,partial,3.9,3.7,3.2,"bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163507,CIP2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.521429,-0.576557,-0.609048
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,20.6,17.3,26.1,"adipose tissue: 26.1 nTPM (manageable, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); salivary gland: 17.3 nTPM (protected, limit 2); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); thyroid gland: 13.6 nTPM (manageable, limit 5); skeletal muscle: 13.6 nTPM (vital, limit 1); pituitary gland: 13.5 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.4 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 2); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 2); small intestine: 10.9 nTPM (vital, limit 1); liver: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 2); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 2); spinal cord: 9.8 nTPM (vital, limit 1); spleen: 9.8 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); lymph node: 9.6 nTPM (protected, limit 2); rectum: 9.5 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163512,AZI2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 38.0048% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.6081% (minimum 99%, Baseline (adaptation disabled)); amygdala: 53.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 52.6316% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 43.7158% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.8365% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.3384% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 52.8053% (minimum 99%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.9710% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.2411% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.9801% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.7945% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 51.2821% (minimum 99%, Baseline (adaptation disabled)); kidney: 52.6316% (minimum 99%, Baseline (adaptation disabled)); liver: 59.4796% (minimum 99%, Baseline (adaptation disabled)); lung: 56.9395% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 53.6913% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.7015% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 56.3380% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 54.2373% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.7451% (minimum 97%, Baseline (adaptation disabled)); retina: 54.7945% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 48.0480% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 54.0541% (minimum 99%, Baseline (adaptation disabled)); skin: 62.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.4796% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.3942% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.0155% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.0155% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.9251% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.8721% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.0541% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.1818% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.8235% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,20.6,17.3,26.1,"adipose tissue: 26.1 nTPM (manageable, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); salivary gland: 17.3 nTPM (protected, limit 2); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); thyroid gland: 13.6 nTPM (manageable, limit 5); skeletal muscle: 13.6 nTPM (vital, limit 1); pituitary gland: 13.5 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.4 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 2); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 2); small intestine: 10.9 nTPM (vital, limit 1); liver: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 2); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 2); spinal cord: 9.8 nTPM (vital, limit 1); spleen: 9.8 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); lymph node: 9.6 nTPM (protected, limit 2); rectum: 9.5 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163512,AZI2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.569952,-0.48952,-0.552842
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 38.0048% (minimum 95%, Missing); adrenal gland: 58.6081% (minimum 99%, Missing); amygdala: 53.3333% (minimum 99%, Missing); basal ganglia: 52.6316% (minimum 99%, Missing); bone marrow: 43.7158% (minimum 99%, Missing); cerebellum: 60.8365% (minimum 99%, Missing); cerebral cortex: 48.3384% (minimum 99%, Missing); choroid plexus: 52.8053% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 57.9710% (minimum 99%, Missing); esophagus: 63.2411% (minimum 97%, Missing); heart muscle: 52.9801% (minimum 99%, Missing); hippocampal formation: 54.7945% (minimum 99%, Missing); hypothalamus: 51.2821% (minimum 99%, Missing); kidney: 52.6316% (minimum 99%, Missing); liver: 59.4796% (minimum 99%, Missing); lung: 56.9395% (minimum 99%, Missing); lymph node: 62.5000% (minimum 97%, Missing); midbrain: 53.6913% (minimum 99%, Missing); pancreas: 59.7015% (minimum 99%, Missing); parathyroid gland: 56.3380% (minimum 97%, Missing); pituitary gland: 54.2373% (minimum 99%, Missing); rectum: 62.7451% (minimum 97%, Missing); retina: 54.7945% (minimum 99%, Missing); salivary gland: 48.0480% (minimum 97%, Missing); skeletal muscle: 54.0541% (minimum 99%, Missing); skin: 62.5000% (minimum 95%, Missing); small intestine: 59.4796% (minimum 99%, Missing); smooth muscle: 58.3942% (minimum 99%, Missing); spinal cord: 62.0155% (minimum 99%, Missing); spleen: 62.0155% (minimum 95%, Missing); stomach: 59.9251% (minimum 97%, Missing); thymus: 53.8721% (minimum 95%, Missing); thyroid gland: 54.0541% (minimum 95%, Missing); tongue: 58.1818% (minimum 97%, Missing); urinary bladder: 58.8235% (minimum 97%, Missing)",0,2,partial,20.6,17.3,26.1,"adipose tissue: 26.1 nTPM (manageable, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); salivary gland: 17.3 nTPM (protected, limit 2); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); thyroid gland: 13.6 nTPM (manageable, limit 5); skeletal muscle: 13.6 nTPM (vital, limit 1); pituitary gland: 13.5 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.4 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 2); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 2); small intestine: 10.9 nTPM (vital, limit 1); liver: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 2); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 2); spinal cord: 9.8 nTPM (vital, limit 1); spleen: 9.8 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); lymph node: 9.6 nTPM (protected, limit 2); rectum: 9.5 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163512,AZI2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.569952,-0.48952,-0.552842
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,72.6,74.1,78.4,"thyroid gland: 78.4 nTPM (manageable, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 2); liver: 72.6 nTPM (vital, limit 1); thymus: 69.9 nTPM (manageable, limit 5); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 2); lymph node: 58.5 nTPM (protected, limit 2); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 2); smooth muscle: 55.6 nTPM (vital, limit 1); tongue: 55.6 nTPM (protected, limit 2); urinary bladder: 54.6 nTPM (protected, limit 2); stomach: 53.7 nTPM (protected, limit 2); salivary gland: 48.5 nTPM (protected, limit 2); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); skin: 43.6 nTPM (manageable, limit 5); esophagus: 43.3 nTPM (protected, limit 2); spleen: 43.1 nTPM (manageable, limit 10); adipose tissue: 41.3 nTPM (manageable, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163527,STT3B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.0637% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.3440% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.5425% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.9556% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.4455% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.2130% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.4790% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.6649% (minimum 99%, Baseline (adaptation disabled)); colon: 61.5077% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.4265% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.0443% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.9042% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.9883% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.8392% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.8101% (minimum 99%, Baseline (adaptation disabled)); liver: 55.9466% (minimum 99%, Baseline (adaptation disabled)); lung: 65.9042% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.1812% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.8828% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.4963% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.4420% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 79.2096% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.7779% (minimum 97%, Baseline (adaptation disabled)); retina: 71.1420% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.5295% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.6180% (minimum 99%, Baseline (adaptation disabled)); skin: 67.8940% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.8571% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.3816% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.2683% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.1449% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.1940% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.8785% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.0445% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.3816% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.8065% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,72.6,74.1,78.4,"thyroid gland: 78.4 nTPM (manageable, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 2); liver: 72.6 nTPM (vital, limit 1); thymus: 69.9 nTPM (manageable, limit 5); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 2); lymph node: 58.5 nTPM (protected, limit 2); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 2); smooth muscle: 55.6 nTPM (vital, limit 1); tongue: 55.6 nTPM (protected, limit 2); urinary bladder: 54.6 nTPM (protected, limit 2); stomach: 53.7 nTPM (protected, limit 2); salivary gland: 48.5 nTPM (protected, limit 2); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); skin: 43.6 nTPM (manageable, limit 5); esophagus: 43.3 nTPM (protected, limit 2); spleen: 43.1 nTPM (manageable, limit 5); adipose tissue: 41.3 nTPM (manageable, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163527,STT3B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.409555,-0.41558,-0.430534
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.0637% (minimum 95%, Missing); adrenal gland: 61.3440% (minimum 99%, Missing); amygdala: 82.5425% (minimum 99%, Missing); basal ganglia: 81.9556% (minimum 99%, Missing); bone marrow: 59.4455% (minimum 99%, Missing); cerebellum: 83.2130% (minimum 99%, Missing); cerebral cortex: 77.4790% (minimum 99%, Missing); choroid plexus: 80.6649% (minimum 99%, Missing); colon: 61.5077% (minimum 97%, Missing); duodenum: 66.4265% (minimum 99%, Missing); esophagus: 68.0443% (minimum 97%, Missing); heart muscle: 65.9042% (minimum 99%, Missing); hippocampal formation: 82.9883% (minimum 99%, Missing); hypothalamus: 82.8392% (minimum 99%, Missing); kidney: 65.8101% (minimum 99%, Missing); liver: 55.9466% (minimum 99%, Missing); lung: 65.9042% (minimum 99%, Missing); lymph node: 61.1812% (minimum 97%, Missing); midbrain: 81.8828% (minimum 99%, Missing); pancreas: 67.4963% (minimum 99%, Missing); parathyroid gland: 55.4420% (minimum 97%, Missing); pituitary gland: 79.2096% (minimum 99%, Missing); rectum: 60.7779% (minimum 97%, Missing); retina: 71.1420% (minimum 99%, Missing); salivary gland: 65.5295% (minimum 97%, Missing); skeletal muscle: 60.6180% (minimum 99%, Missing); skin: 67.8940% (minimum 95%, Missing); small intestine: 65.8571% (minimum 99%, Missing); smooth muscle: 62.3816% (minimum 99%, Missing); spinal cord: 78.2683% (minimum 99%, Missing); spleen: 68.1449% (minimum 90%, Approved); stomach: 63.1940% (minimum 97%, Missing); thymus: 56.8785% (minimum 95%, Missing); thyroid gland: 54.0445% (minimum 95%, Missing); tongue: 62.3816% (minimum 97%, Missing); urinary bladder: 62.8065% (minimum 97%, Missing)",0,4,partial,72.6,74.1,78.4,"thyroid gland: 78.4 nTPM (manageable, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 2); liver: 72.6 nTPM (vital, limit 1); thymus: 69.9 nTPM (manageable, limit 5); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 2); lymph node: 58.5 nTPM (protected, limit 2); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 2); smooth muscle: 55.6 nTPM (vital, limit 1); tongue: 55.6 nTPM (protected, limit 2); urinary bladder: 54.6 nTPM (protected, limit 2); stomach: 53.7 nTPM (protected, limit 2); salivary gland: 48.5 nTPM (protected, limit 2); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); skin: 43.6 nTPM (manageable, limit 5); esophagus: 43.3 nTPM (protected, limit 2); spleen: 43.1 nTPM (manageable, limit 10); adipose tissue: 41.3 nTPM (manageable, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163527,STT3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.409555,-0.41558,-0.430534
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000163530,DPPA2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 96.9697% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000163530,DPPA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.019697,0.03,-0.020303
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 96.9697% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000163530,DPPA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.019697,0.03,-0.020303
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,12,partial,6.7,7.8,14.5,"thymus: 14.5 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); bone marrow: 6.7 nTPM (vital, limit 6); rectum: 3.1 nTPM (protected, limit 2); colon: 3 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2)",bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000163535,SGO2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.8046% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.5309% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.4424% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.4424% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.5065% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1366% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.9325% (minimum 99%, Baseline (adaptation disabled)); colon: 91.3295% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.9412% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.2153% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.2308% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.4424% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.1366% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5309% (minimum 99%, Baseline (adaptation disabled)); liver: 97.5309% (minimum 99%, Baseline (adaptation disabled)); lung: 95.7576% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.2030% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.1366% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.7500% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.6361% (minimum 97%, Baseline (adaptation disabled)); rectum: 91.0663% (minimum 97%, Baseline (adaptation disabled)); retina: 97.2308% (minimum 99%, Baseline (adaptation disabled)); skin: 93.4911% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.6686% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.0476% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.1366% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.0476% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.8949% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.5466% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.4683% (minimum 97%, Baseline (adaptation disabled))",0,12,partial,6.7,7.8,14.5,"thymus: 14.5 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); bone marrow: 6.7 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); colon: 3 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000163535,SGO2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.264534,-0.16797,-0.164935
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.4424% (minimum 99%, Missing); basal ganglia: 98.4424% (minimum 99%, Missing); bone marrow: 82.5065% (minimum 95%, Enhanced); colon: 91.3295% (minimum 97%, Missing); duodenum: 92.9412% (minimum 99%, Missing); esophagus: 93.2153% (minimum 97%, Missing); hippocampal formation: 98.4424% (minimum 99%, Missing); hypothalamus: 98.1366% (minimum 99%, Missing); lymph node: 80.2030% (minimum 97%, Missing); midbrain: 98.1366% (minimum 99%, Missing); rectum: 91.0663% (minimum 97%, Missing); retina: 97.2308% (minimum 99%, Missing); skin: 93.4911% (minimum 95%, Missing); small intestine: 92.6686% (minimum 99%, Missing); smooth muscle: 94.0476% (minimum 95%, Enhanced); spinal cord: 98.1366% (minimum 99%, Missing); stomach: 94.8949% (minimum 97%, Missing); thymus: 68.5466% (minimum 95%, Missing)",0,12,partial,6.7,7.8,14.5,"thymus: 14.5 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); bone marrow: 6.7 nTPM (vital, limit 6); rectum: 3.1 nTPM (protected, limit 2); colon: 3 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2)",bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000163535,SGO2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.264534,-0.16797,-0.124935
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,74.7,0,1.1,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / melanocytes; spleen; thymus,ENSG00000163554,SPTA1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.1176% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 2.0970% (minimum 99%, Baseline (adaptation disabled)); liver: 94.1176% (minimum 99%, Baseline (adaptation disabled)); lung: 94.1176% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.2593% (minimum 95%, Baseline (adaptation disabled)); thymus: 80.0000% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,74.7,0,1.1,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / melanocytes; spleen; thymus,ENSG00000163554,SPTA1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.357407,0.03,-0.96903
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 2.0970% (minimum 99%, Missing); liver: 94.1176% (minimum 95%, Enhanced); lung: 94.1176% (minimum 95%, Enhanced); spleen: 59.2593% (minimum 60%, Enhanced); thymus: 80.0000% (minimum 95%, Missing)",0,1,partial,74.7,0,1.1,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / melanocytes; spleen; thymus,ENSG00000163554,SPTA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.15,0.03,-0.96903
True,compatible,,True,True,False,,0,4,partial,0.6,0.6,1.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000163645,ERICH6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.2993% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6348% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.9661% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.9726% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.9661% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9726% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,0.6,0.6,1.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000163645,ERICH6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.00695364,0.00966102,-0.010339
True,compatible,,True,True,True,,0,4,partial,0.6,0.6,1.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000163645,ERICH6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0265517,0.00312715
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,12.4,0,0.1,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000163646,CLRN1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 5.8824% (minimum 99%, Baseline (adaptation disabled)); duodenum: 18.7500% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 2.3622% (minimum 99%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 60.0000% (minimum 99%, Baseline (adaptation disabled)); thymus: 75.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,12.4,0,0.1,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000163646,CLRN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.2,0.03,-0.966378
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 5.8824% (minimum 99%, Missing); duodenum: 18.7500% (minimum 99%, Missing); pituitary gland: 60.0000% (minimum 99%, Missing); retina: 2.3622% (minimum 99%, Missing); small intestine: 60.0000% (minimum 99%, Missing); spinal cord: 60.0000% (minimum 99%, Missing); thymus: 75.0000% (minimum 95%, Missing)",0,80,unavailable,12.4,0,0.1,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000163646,CLRN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.2,0.03,-0.966378
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,39.2,37.5,6.3,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 2); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 2); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); rectum: 6.2 nTPM (protected, limit 2); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 2); pituitary gland: 5.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); stomach: 5.2 nTPM (protected, limit 2); skin: 5.1 nTPM (manageable, limit 5); urinary bladder: 5 nTPM (protected, limit 2); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163684,RPP14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.4563% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 49.0741% (minimum 99%, Baseline (adaptation disabled)); amygdala: 56.9892% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 51.4563% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 53.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 45.2991% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.2273% (minimum 99%, Baseline (adaptation disabled)); colon: 44.5378% (minimum 97%, Baseline (adaptation disabled)); duodenum: 44.5378% (minimum 99%, Baseline (adaptation disabled)); esophagus: 48.1818% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 33.5443% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.6087% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 56.3830% (minimum 99%, Baseline (adaptation disabled)); kidney: 37.8571% (minimum 99%, Baseline (adaptation disabled)); liver: 32.1212% (minimum 99%, Baseline (adaptation disabled)); lung: 57.6087% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.6087% (minimum 97%, Baseline (adaptation disabled)); midbrain: 59.5506% (minimum 99%, Baseline (adaptation disabled)); pancreas: 47.3214% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 41.7323% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 48.1818% (minimum 99%, Baseline (adaptation disabled)); rectum: 46.0870% (minimum 97%, Baseline (adaptation disabled)); retina: 51.9608% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 52.4752% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 11.9101% (minimum 99%, Baseline (adaptation disabled)); skin: 50.9615% (minimum 95%, Baseline (adaptation disabled)); small intestine: 44.1667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 43.4426% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.6279% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.6239% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.4762% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.6897% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 12.3832% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.4563% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,39.2,37.5,6.3,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 2); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 2); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); rectum: 6.2 nTPM (protected, limit 2); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 2); pituitary gland: 5.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); stomach: 5.2 nTPM (protected, limit 2); skin: 5.1 nTPM (manageable, limit 5); urinary bladder: 5 nTPM (protected, limit 2); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163684,RPP14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.493103,-0.846168,-0.870899
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.4563% (minimum 95%, Missing); adrenal gland: 49.0741% (minimum 99%, Missing); amygdala: 56.9892% (minimum 99%, Missing); basal ganglia: 51.4563% (minimum 99%, Missing); bone marrow: 53.0000% (minimum 99%, Missing); cerebellum: 45.2991% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); choroid plexus: 60.2273% (minimum 99%, Missing); colon: 44.5378% (minimum 97%, Missing); duodenum: 44.5378% (minimum 99%, Missing); esophagus: 48.1818% (minimum 97%, Missing); heart muscle: 33.5443% (minimum 99%, Missing); hippocampal formation: 57.6087% (minimum 99%, Missing); hypothalamus: 56.3830% (minimum 99%, Missing); kidney: 37.8571% (minimum 99%, Missing); liver: 32.1212% (minimum 99%, Missing); lung: 57.6087% (minimum 99%, Missing); lymph node: 57.6087% (minimum 97%, Missing); midbrain: 59.5506% (minimum 99%, Missing); pancreas: 47.3214% (minimum 99%, Missing); parathyroid gland: 41.7323% (minimum 97%, Missing); pituitary gland: 48.1818% (minimum 99%, Missing); rectum: 46.0870% (minimum 97%, Missing); retina: 51.9608% (minimum 99%, Missing); salivary gland: 52.4752% (minimum 97%, Missing); skeletal muscle: 11.9101% (minimum 99%, Missing); skin: 50.9615% (minimum 95%, Missing); small intestine: 44.1667% (minimum 99%, Missing); smooth muscle: 43.4426% (minimum 99%, Missing); spinal cord: 61.6279% (minimum 99%, Missing); spleen: 48.6239% (minimum 95%, Missing); stomach: 50.4762% (minimum 97%, Missing); thymus: 45.6897% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 12.3832% (minimum 97%, Missing); urinary bladder: 51.4563% (minimum 97%, Missing)",0,80,unavailable,39.2,37.5,6.3,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 2); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 2); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); rectum: 6.2 nTPM (protected, limit 2); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 2); pituitary gland: 5.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); stomach: 5.2 nTPM (protected, limit 2); skin: 5.1 nTPM (manageable, limit 5); urinary bladder: 5 nTPM (protected, limit 2); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163684,RPP14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.493103,-0.846168,-0.870899
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.8,7.7,0.5,"esophagus: 7.7 nTPM (protected, limit 2); pituitary gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163689,CFAP20DC,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5947% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.6364% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.7477% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.7477% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.8095% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 98.6364% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.7477% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.1900% (minimum 99%, Baseline (adaptation disabled)); liver: 95.5947% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1900% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.5345% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.6364% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7477% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.8750% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.3404% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.8750% (minimum 97%, Baseline (adaptation disabled)); retina: 98.1900% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.9492% (minimum 97%, Baseline (adaptation disabled)); smooth muscle: 98.6364% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.8,7.7,0.5,"esophagus: 7.7 nTPM (protected, limit 2); pituitary gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163689,CFAP20DC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0274775,-0.231905,-0.0665957
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5947% (minimum 99%, Missing); amygdala: 98.6364% (minimum 99%, Missing); basal ganglia: 97.7477% (minimum 99%, Missing); cerebral cortex: 97.7477% (minimum 99%, Missing); esophagus: 73.8095% (minimum 97%, Missing); hippocampal formation: 98.6364% (minimum 99%, Missing); hypothalamus: 97.7477% (minimum 99%, Missing); kidney: 98.1900% (minimum 99%, Missing); liver: 95.5947% (minimum 99%, Missing); lung: 98.1900% (minimum 99%, Missing); lymph node: 93.5345% (minimum 97%, Missing); midbrain: 98.6364% (minimum 99%, Missing); pancreas: 97.7477% (minimum 99%, Missing); parathyroid gland: 96.8750% (minimum 97%, Missing); pituitary gland: 92.3404% (minimum 99%, Missing); rectum: 96.8750% (minimum 97%, Missing); retina: 98.1900% (minimum 99%, Missing); salivary gland: 91.9492% (minimum 97%, Missing); smooth muscle: 98.6364% (minimum 99%, Missing)",0,80,unavailable,1.8,7.7,0.5,"esophagus: 7.7 nTPM (protected, limit 2); pituitary gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000163689,CFAP20DC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0274775,-0.231905,-0.0665957
True,compatible,,True,True,False,,0,80,unavailable,1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,ENSG00000163705,FANCD2OS,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.3580% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,ENSG00000163705,FANCD2OS,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0433665,0.0283333,-0.00642036
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.3580% (minimum 99%, Missing)",0,80,unavailable,1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,ENSG00000163705,FANCD2OS,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0433665,0.0283333,-0.00642036
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.3,0.4,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000163746,PLSCR2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 92.3077% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.5075% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.3504% (minimum 99%, Baseline (adaptation disabled)); liver: 98.5075% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.3504% (minimum 99%, Baseline (adaptation disabled)); retina: 96.3504% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5075% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5075% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.3,0.4,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000163746,PLSCR2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0205882,0.00777778,-0.0669231
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 92.3077% (minimum 99%, Missing); duodenum: 98.5075% (minimum 99%, Missing); kidney: 96.3504% (minimum 99%, Missing); liver: 98.5075% (minimum 99%, Missing); pancreas: 96.3504% (minimum 99%, Missing); retina: 96.3504% (minimum 99%, Missing); small intestine: 98.5075% (minimum 99%, Missing); smooth muscle: 98.5075% (minimum 99%, Missing)",0,80,unavailable,1.1,0.3,0.4,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000163746,PLSCR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0205882,0.00777778,-0.0669231
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,0.5,1.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000163749,CCDC158,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 98.5207% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.8131% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.5207% (minimum 99%, Baseline (adaptation disabled)); liver: 95.4155% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.5207% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.8131% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.6,0.5,1.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000163749,CCDC158,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0124277,0.0152071,-0.0358453
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 98.5207% (minimum 99%, Missing); heart muscle: 98.8131% (minimum 99%, Missing); kidney: 98.5207% (minimum 99%, Missing); liver: 95.4155% (minimum 99%, Missing); pituitary gland: 98.5207% (minimum 99%, Missing); smooth muscle: 98.8131% (minimum 99%, Missing)",0,80,unavailable,1.6,0.5,1.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000163749,CCDC158,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0124277,0.0152071,-0.0358453
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,2.2,0.1,0.1,"cerebral cortex: 2.2 nTPM (vital, limit 2)",,53,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000163793,DNAJC5G,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2796% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.4071% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.2340% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,2.2,0.1,0.1,"cerebral cortex: 2.2 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,53,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000163793,DNAJC5G,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,0.0478166,0.0278166,-0.035929
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 95.4071% (minimum 98%, Approved); heart muscle: 97.2340% (minimum 98%, Approved)",0,2,partial,2.2,0.1,0.1,"cerebral cortex: 2.2 nTPM (vital, limit 2)",,53,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000163793,DNAJC5G,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,0.05,0.03,-0.025929
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,2.3,0.9,1.8,"pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000163806,SPDYA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.2644% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.3855% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.0961% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.1595% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.2945% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.6767% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.7654% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.5610% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.0961% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.3855% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.2381% (minimum 99%, Baseline (adaptation disabled)); liver: 95.8084% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1595% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.6767% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.5610% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.8084% (minimum 99%, Baseline (adaptation disabled)); retina: 96.9697% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.2644% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.6767% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.6746% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,2.3,0.9,1.8,"cerebellum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000163806,SPDYA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00325444,0.00264438,-0.0570554
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.3855% (minimum 99%, Missing); basal ganglia: 96.0961% (minimum 99%, Missing); cerebellum: 93.2945% (minimum 95%, Enhanced); hippocampal formation: 96.0961% (minimum 99%, Missing); hypothalamus: 96.3855% (minimum 99%, Missing); midbrain: 96.6767% (minimum 99%, Missing); pituitary gland: 95.8084% (minimum 99%, Missing); retina: 96.9697% (minimum 99%, Missing); spinal cord: 96.6767% (minimum 99%, Missing)",0,1,partial,2.3,0.9,1.8,"pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000163806,SPDYA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.0319162
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,5.1,2.2,9,"thymus: 9 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thymus / cortical cells: High (Approved); thymus / medullary cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000163808,KIF15,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.6111% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.6111% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 58.1967% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.9459% (minimum 99%, Baseline (adaptation disabled)); colon: 83.5294% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.5238% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.5854% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 98.6111% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6111% (minimum 99%, Baseline (adaptation disabled)); lung: 97.2603% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.3441% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.6111% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.5581% (minimum 97%, Baseline (adaptation disabled)); retina: 98.6111% (minimum 99%, Baseline (adaptation disabled)); skin: 89.8734% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.5294% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.8734% (minimum 97%, Baseline (adaptation disabled)); thymus: 44.0994% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.9459% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,5.1,2.2,9,"thymus: 9 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thymus / cortical cells: High (Approved); thymus / medullary cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000163808,KIF15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.509006,-0.206559,-0.408033
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.6111% (minimum 99%, Missing); basal ganglia: 98.6111% (minimum 99%, Missing); bone marrow: 58.1967% (minimum 99%, Missing); cerebral cortex: 95.9459% (minimum 99%, Missing); colon: 83.5294% (minimum 97%, Missing); duodenum: 84.5238% (minimum 99%, Missing); esophagus: 86.5854% (minimum 95%, Approved); hippocampal formation: 98.6111% (minimum 99%, Missing); lung: 97.2603% (minimum 98%, Approved); lymph node: 76.3441% (minimum 97%, Missing); midbrain: 98.6111% (minimum 99%, Missing); rectum: 82.5581% (minimum 97%, Missing); retina: 98.6111% (minimum 99%, Missing); skin: 89.8734% (minimum 90%, Approved); small intestine: 83.5294% (minimum 99%, Missing); smooth muscle: 94.6667% (minimum 99%, Missing); spleen: 94.6667% (minimum 95%, Missing); stomach: 89.8734% (minimum 97%, Missing); thymus: 44.0994% (minimum 95%, Missing); urinary bladder: 95.9459% (minimum 97%, Missing)",0,5,partial,5.1,2.2,9,"thymus: 9 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thymus / cortical cells: High (Approved); thymus / medullary cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000163808,KIF15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.509006,-0.206559,-0.408033
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,15.3,9.3,10.3,"bone marrow: 15.3 nTPM (vital, limit 1); spleen: 10.3 nTPM (manageable, limit 5); lymph node: 9.3 nTPM (protected, limit 2); thyroid gland: 9.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 2); adrenal gland: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 2); cerebral cortex: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163867,ZMYM6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 55.7576% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.3103% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.4098% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 37.5510% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.1622% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.3357% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.7018% (minimum 99%, Baseline (adaptation disabled)); colon: 60.5263% (minimum 97%, Baseline (adaptation disabled)); duodenum: 59.7403% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.8616% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.5987% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.3103% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.5987% (minimum 99%, Baseline (adaptation disabled)); liver: 67.1533% (minimum 99%, Baseline (adaptation disabled)); lung: 59.7403% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.7297% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.3103% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.7143% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.7576% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.8616% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.0976% (minimum 97%, Baseline (adaptation disabled)); retina: 50.5495% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.7887% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 73.0159% (minimum 99%, Baseline (adaptation disabled)); skin: 53.4884% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.1429% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.3548% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.1935% (minimum 99%, Baseline (adaptation disabled)); spleen: 47.1795% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.7901% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.8012% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.1533% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.4483% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,15.3,9.3,10.3,"bone marrow: 15.3 nTPM (vital, limit 1); spleen: 10.3 nTPM (manageable, limit 5); lymph node: 9.3 nTPM (protected, limit 2); thyroid gland: 9.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 2); adrenal gland: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 2); cerebral cortex: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163867,ZMYM6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.478205,-0.472703,-0.61449
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 95%, Missing); adrenal gland: 55.7576% (minimum 99%, Missing); amygdala: 79.3103% (minimum 99%, Missing); basal ganglia: 75.4098% (minimum 99%, Missing); bone marrow: 37.5510% (minimum 99%, Missing); cerebellum: 62.1622% (minimum 99%, Missing); cerebral cortex: 64.3357% (minimum 99%, Missing); choroid plexus: 80.7018% (minimum 99%, Missing); colon: 60.5263% (minimum 97%, Missing); duodenum: 59.7403% (minimum 99%, Missing); esophagus: 57.8616% (minimum 97%, Missing); heart muscle: 58.5987% (minimum 99%, Missing); hippocampal formation: 79.3103% (minimum 99%, Missing); hypothalamus: 76.6667% (minimum 99%, Missing); kidney: 58.5987% (minimum 99%, Missing); liver: 67.1533% (minimum 99%, Missing); lung: 59.7403% (minimum 99%, Missing); lymph node: 49.7297% (minimum 97%, Missing); midbrain: 79.3103% (minimum 99%, Missing); pancreas: 65.7143% (minimum 99%, Missing); parathyroid gland: 55.7576% (minimum 97%, Missing); pituitary gland: 57.8616% (minimum 99%, Missing); rectum: 56.0976% (minimum 97%, Missing); retina: 50.5495% (minimum 99%, Missing); salivary gland: 64.7887% (minimum 97%, Missing); skeletal muscle: 73.0159% (minimum 99%, Missing); skin: 53.4884% (minimum 95%, Missing); small intestine: 57.1429% (minimum 99%, Missing); smooth muscle: 59.3548% (minimum 99%, Missing); spinal cord: 74.1935% (minimum 99%, Missing); spleen: 47.1795% (minimum 95%, Missing); stomach: 56.7901% (minimum 97%, Missing); thymus: 53.8012% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 67.1533% (minimum 97%, Missing); urinary bladder: 63.4483% (minimum 97%, Missing)",0,2,partial,15.3,9.3,10.3,"bone marrow: 15.3 nTPM (vital, limit 1); spleen: 10.3 nTPM (manageable, limit 5); lymph node: 9.3 nTPM (protected, limit 2); thyroid gland: 9.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 2); adrenal gland: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 2); cerebral cortex: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000163867,ZMYM6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.478205,-0.472703,-0.61449
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,10,partial,77.1,8.8,10.3,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 6); liver: 11.7 nTPM (vital, limit 6); retina: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 6); pancreas: 8.9 nTPM (vital, limit 6); cerebral cortex: 7.5 nTPM (vital, limit 6); stomach: 6.2 nTPM (protected, limit 2); colon: 5.1 nTPM (protected, limit 2); salivary gland: 4.4 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); salivary gland / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Gradient; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000163879,DNALI1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 89.9317% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.5182% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.7044% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.6140% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.5415% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 40.6009% (minimum 99%, Baseline (adaptation disabled)); colon: 91.1765% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.7737% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.2984% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.1071% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.3438% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.1596% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.7054% (minimum 99%, Baseline (adaptation disabled)); liver: 81.8323% (minimum 99%, Baseline (adaptation disabled)); lung: 83.9172% (minimum 99%, Baseline (adaptation disabled)); midbrain: 82.3438% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.5519% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.6911% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 81.0769% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.9927% (minimum 97%, Baseline (adaptation disabled)); retina: 82.0872% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.2942% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.9554% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.9927% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.9453% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.3438% (minimum 99%, Baseline (adaptation disabled)); stomach: 89.4737% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 83.6508% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.4397% (minimum 97%, Baseline (adaptation disabled))",0,10,partial,77.1,8.8,10.3,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 1); liver: 11.7 nTPM (vital, limit 1); retina: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); pancreas: 8.9 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 2); cerebral cortex: 7.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2); adrenal gland: 5.9 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); salivary gland: 4.4 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 2); heart muscle: 3.3 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); esophagus: 2.6 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); salivary gland / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Gradient; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000163879,DNALI1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.113492,-0.113089,-0.583991
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 89.9317% (minimum 95%, Enhanced); amygdala: 83.5182% (minimum 99%, Missing); basal ganglia: 80.7044% (minimum 99%, Missing); cerebellum: 94.6140% (minimum 95%, Enhanced); cerebral cortex: 87.5415% (minimum 95%, Enhanced); choroid plexus: 40.6009% (minimum 99%, Missing); colon: 91.1765% (minimum 97%, Missing); duodenum: 97.7737% (minimum 99%, Missing); heart muscle: 94.1071% (minimum 95%, Enhanced); hippocampal formation: 82.3438% (minimum 99%, Missing); hypothalamus: 77.1596% (minimum 99%, Missing); kidney: 81.7054% (minimum 95%, Enhanced); liver: 81.8323% (minimum 95%, Enhanced); lung: 83.9172% (minimum 95%, Enhanced); midbrain: 82.3438% (minimum 99%, Missing); pancreas: 85.5519% (minimum 95%, Enhanced); pituitary gland: 81.0769% (minimum 99%, Missing); rectum: 95.9927% (minimum 97%, Missing); retina: 82.0872% (minimum 99%, Missing); salivary gland: 92.2942% (minimum 97%, Missing); small intestine: 95.9927% (minimum 99%, Missing); smooth muscle: 92.9453% (minimum 95%, Enhanced); spinal cord: 82.3438% (minimum 99%, Missing); stomach: 89.4737% (minimum 97%, Missing)",0,10,partial,77.1,8.8,10.3,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 6); liver: 11.7 nTPM (vital, limit 6); retina: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 6); pancreas: 8.9 nTPM (vital, limit 6); cerebral cortex: 7.5 nTPM (vital, limit 6); stomach: 6.2 nTPM (protected, limit 2); colon: 5.1 nTPM (protected, limit 2); salivary gland: 4.4 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); salivary gland / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Gradient; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000163879,DNALI1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0368914,-0.0752632,-0.583991
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,13,0.1,0.1,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000163885,CFAP100,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.1662% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.7436% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.7865% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.0405% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.2579% (minimum 99%, Baseline (adaptation disabled)); lung: 84.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.4375% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.4375% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,13,0.1,0.1,"choroid plexus: 13 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000163885,CFAP100,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0468354,0.0268354,-0.282135
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.1662% (minimum 99%, Missing); basal ganglia: 89.7436% (minimum 99%, Missing); choroid plexus: 70.7865% (minimum 99%, Missing); hippocampal formation: 91.0405% (minimum 99%, Missing); hypothalamus: 90.2579% (minimum 99%, Missing); lung: 84.0000% (minimum 95%, Enhanced); midbrain: 98.4375% (minimum 99%, Missing); spinal cord: 98.4375% (minimum 99%, Missing)",0,4,partial,13,0.1,0.1,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000163885,CFAP100,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.282135
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,19.8,12.9,16.1,"pancreas: 19.8 nTPM (vital, limit 2); bone marrow: 19.1 nTPM (vital, limit 2); thymus: 16.1 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 4); colon: 12.1 nTPM (protected, limit 2); amygdala: 11.7 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 10); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 4); urinary bladder: 8.2 nTPM (protected, limit 4); salivary gland: 8.1 nTPM (protected, limit 2); smooth muscle: 7.9 nTPM (vital, limit 2); retina: 7.3 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 4); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 4); lung: 5.3 nTPM (vital, limit 2); pituitary gland: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 2); tongue: 2.2 nTPM (protected, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000163923,RPL39L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.6031% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.5933% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.8124% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.4656% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2246% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.0325% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.8765% (minimum 99%, Baseline (adaptation disabled)); colon: 94.4188% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.4135% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.9231% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.8124% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.5203% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.5649% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.8307% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8957% (minimum 99%, Baseline (adaptation disabled)); lung: 97.4762% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.0717% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.6989% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.1804% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.8022% (minimum 99%, Baseline (adaptation disabled)); retina: 96.5566% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.1936% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.9845% (minimum 99%, Baseline (adaptation disabled)); skin: 94.6371% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.1523% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.2841% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.8333% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.8765% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.7083% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.1484% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,19.8,12.9,16.1,"pancreas: 19.8 nTPM (vital, limit 1); bone marrow: 19.1 nTPM (vital, limit 1); thymus: 16.1 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 2); colon: 12.1 nTPM (protected, limit 2); amygdala: 11.7 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); urinary bladder: 8.2 nTPM (protected, limit 2); salivary gland: 8.1 nTPM (protected, limit 2); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.5 nTPM (manageable, limit 5); retina: 7.3 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 2); choroid plexus: 6.6 nTPM (vital, limit 1); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000163923,RPL39L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0229167,-0.0292831,-0.078196
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 94.5933% (minimum 99%, Missing); basal ganglia: 94.8124% (minimum 99%, Missing); bone marrow: 91.4656% (minimum 98%, Approved); cerebral cortex: 95.0325% (minimum 98%, Approved); choroid plexus: 96.8765% (minimum 99%, Missing); colon: 94.4188% (minimum 97%, Missing); duodenum: 98.4135% (minimum 99%, Missing); heart muscle: 94.8124% (minimum 99%, Missing); hippocampal formation: 95.5203% (minimum 99%, Missing); hypothalamus: 95.5649% (minimum 99%, Missing); kidney: 96.8307% (minimum 99%, Missing); liver: 97.8957% (minimum 99%, Missing); lung: 97.4762% (minimum 98%, Approved); lymph node: 94.0717% (minimum 95%, Approved); midbrain: 95.6989% (minimum 99%, Missing); pancreas: 91.1804% (minimum 98%, Approved); pituitary gland: 97.8022% (minimum 99%, Missing); retina: 96.5566% (minimum 99%, Missing); salivary gland: 96.1936% (minimum 97%, Missing); skeletal muscle: 98.9845% (minimum 99%, Missing); small intestine: 97.1523% (minimum 99%, Missing); smooth muscle: 96.2841% (minimum 98%, Approved); spinal cord: 95.8333% (minimum 99%, Missing); thymus: 92.7083% (minimum 95%, Missing)",0,4,partial,19.8,12.9,16.1,"pancreas: 19.8 nTPM (vital, limit 2); bone marrow: 19.1 nTPM (vital, limit 2); thymus: 16.1 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 4); colon: 12.1 nTPM (protected, limit 2); amygdala: 11.7 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 10); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 4); urinary bladder: 8.2 nTPM (protected, limit 4); salivary gland: 8.1 nTPM (protected, limit 2); smooth muscle: 7.9 nTPM (vital, limit 2); retina: 7.3 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 4); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 4); lung: 5.3 nTPM (vital, limit 2); pituitary gland: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 2); tongue: 2.2 nTPM (protected, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000163923,RPL39L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0229167,-0.0258118,-0.068196
True,compatible,,True,True,False,,0,80,unavailable,0.8,0,1.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000163958,ZDHHC19,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.3838% (minimum 99%, Baseline (adaptation disabled)); liver: 98.7830% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0,1.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000163958,ZDHHC19,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0201195,0.03,-0.00616162
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.3838% (minimum 99%, Missing); liver: 98.7830% (minimum 99%, Missing)",0,80,unavailable,0.8,0,1.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000163958,ZDHHC19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0201195,0.03,-0.00616162
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,16,partial,27.7,15.8,17.5,"smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 6); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); urinary bladder: 13.4 nTPM (protected, limit 2); colon: 11.9 nTPM (protected, limit 2); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 2); salivary gland: 9 nTPM (protected, limit 2); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / enterocytes - Microvilli; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164023,SGMS2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8039% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.7947% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.7293% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.7698% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.0539% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.8462% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.2208% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 43.8849% (minimum 99%, Baseline (adaptation disabled)); colon: 50.6224% (minimum 97%, Baseline (adaptation disabled)); duodenum: 39.2283% (minimum 99%, Baseline (adaptation disabled)); esophagus: 43.5714% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.0952% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.4058% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.4058% (minimum 99%, Baseline (adaptation disabled)); kidney: 46.7433% (minimum 99%, Baseline (adaptation disabled)); liver: 38.3648% (minimum 99%, Baseline (adaptation disabled)); lung: 31.4433% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.7293% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.5248% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.9149% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.7070% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.0539% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.4643% (minimum 97%, Baseline (adaptation disabled)); retina: 93.8462% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.5472% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.5616% (minimum 99%, Baseline (adaptation disabled)); skin: 77.7070% (minimum 95%, Baseline (adaptation disabled)); small intestine: 43.8849% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 30.5764% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.7097% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.4242% (minimum 95%, Baseline (adaptation disabled)); stomach: 47.6562% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.8462% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 41.0774% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.7097% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 47.6562% (minimum 97%, Baseline (adaptation disabled))",0,16,partial,27.7,15.8,17.5,"smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 2); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); urinary bladder: 13.4 nTPM (protected, limit 2); colon: 11.9 nTPM (protected, limit 2); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 2); salivary gland: 9 nTPM (protected, limit 2); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / enterocytes - Microvilli; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164023,SGMS2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.539226,-0.534286,-0.684236
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8039% (minimum 95%, Missing); adrenal gland: 80.7947% (minimum 99%, Missing); amygdala: 91.7293% (minimum 99%, Missing); basal ganglia: 87.7698% (minimum 99%, Missing); bone marrow: 73.0539% (minimum 99%, Missing); cerebellum: 93.8462% (minimum 99%, Missing); cerebral cortex: 79.2208% (minimum 99%, Missing); choroid plexus: 43.8849% (minimum 99%, Missing); colon: 50.6224% (minimum 97%, Missing); duodenum: 39.2283% (minimum 99%, Missing); esophagus: 43.5714% (minimum 90%, Supported); heart muscle: 58.0952% (minimum 99%, Missing); hippocampal formation: 88.4058% (minimum 99%, Missing); hypothalamus: 88.4058% (minimum 99%, Missing); kidney: 46.7433% (minimum 99%, Missing); liver: 38.3648% (minimum 99%, Missing); lung: 31.4433% (minimum 99%, Missing); lymph node: 91.7293% (minimum 97%, Missing); midbrain: 86.5248% (minimum 99%, Missing); pancreas: 51.9149% (minimum 99%, Missing); parathyroid gland: 77.7070% (minimum 97%, Missing); pituitary gland: 73.0539% (minimum 99%, Missing); rectum: 54.4643% (minimum 97%, Missing); retina: 93.8462% (minimum 99%, Missing); salivary gland: 57.5472% (minimum 97%, Missing); skeletal muscle: 83.5616% (minimum 99%, Missing); skin: 77.7070% (minimum 95%, Missing); small intestine: 43.8849% (minimum 99%, Missing); smooth muscle: 30.5764% (minimum 99%, Missing); spinal cord: 78.7097% (minimum 99%, Missing); spleen: 92.4242% (minimum 95%, Missing); stomach: 47.6562% (minimum 97%, Missing); thymus: 93.8462% (minimum 95%, Missing); thyroid gland: 41.0774% (minimum 95%, Missing); tongue: 78.7097% (minimum 97%, Missing); urinary bladder: 47.6562% (minimum 97%, Missing)",0,16,partial,27.7,15.8,17.5,"smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 6); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); urinary bladder: 13.4 nTPM (protected, limit 2); colon: 11.9 nTPM (protected, limit 2); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 2); salivary gland: 9 nTPM (protected, limit 2); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / enterocytes - Microvilli; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164023,SGMS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.539226,-0.493438,-0.684236
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,0.9,1.8,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164037,SLC9B1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.4925% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.5124% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.2456% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.2456% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9899% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.7406% (minimum 99%, Baseline (adaptation disabled)); lung: 98.7406% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.7406% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.0297% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.7406% (minimum 99%, Baseline (adaptation disabled)); retina: 95.8435% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.7406% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.4925% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.7,0.9,1.8,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164037,SLC9B1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.00609756,0.00755611,-0.0315648
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.0000% (minimum 99%, Missing); bone marrow: 98.4925% (minimum 99%, Missing); cerebral cortex: 97.5124% (minimum 99%, Missing); choroid plexus: 98.2456% (minimum 99%, Missing); duodenum: 98.2456% (minimum 99%, Missing); heart muscle: 98.0000% (minimum 99%, Missing); hippocampal formation: 98.9899% (minimum 99%, Missing); kidney: 98.7406% (minimum 99%, Missing); lung: 98.7406% (minimum 99%, Missing); midbrain: 98.7406% (minimum 99%, Missing); pancreas: 97.0297% (minimum 99%, Missing); pituitary gland: 98.7406% (minimum 99%, Missing); retina: 95.8435% (minimum 99%, Missing); small intestine: 98.7406% (minimum 99%, Missing); smooth muscle: 98.4925% (minimum 99%, Missing); spinal cord: 98.0000% (minimum 99%, Missing)",0,80,unavailable,1.7,0.9,1.8,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164037,SLC9B1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.00609756,0.00755611,-0.0315648
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,15.1,4.3,8.6,"bone marrow: 15.1 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164045,CDC25A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.4783% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.5556% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.5556% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 46.0714% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.9925% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.5556% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7273% (minimum 99%, Baseline (adaptation disabled)); colon: 79.1411% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.5772% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.8684% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.9925% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.9925% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.8451% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.5556% (minimum 99%, Baseline (adaptation disabled)); liver: 94.8529% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7273% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.1606% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.8529% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.8529% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.8529% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.2455% (minimum 97%, Baseline (adaptation disabled)); retina: 87.1622% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.8529% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.9925% (minimum 99%, Baseline (adaptation disabled)); small intestine: 87.7551% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.8058% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.4733% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.1622% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.4783% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.3562% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.4783% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,15.1,4.3,8.6,"bone marrow: 15.1 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164045,CDC25A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.35,-0.22,-0.529286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.4783% (minimum 99%, Missing); amygdala: 95.5556% (minimum 99%, Missing); basal ganglia: 95.5556% (minimum 99%, Missing); bone marrow: 46.0714% (minimum 99%, Missing); cerebellum: 96.9925% (minimum 99%, Missing); cerebral cortex: 95.5556% (minimum 99%, Missing); choroid plexus: 97.7273% (minimum 99%, Missing); colon: 79.1411% (minimum 97%, Missing); duodenum: 86.5772% (minimum 99%, Missing); esophagus: 84.8684% (minimum 97%, Missing); heart muscle: 96.9925% (minimum 99%, Missing); hippocampal formation: 96.9925% (minimum 99%, Missing); hypothalamus: 90.8451% (minimum 99%, Missing); kidney: 95.5556% (minimum 99%, Missing); liver: 94.8529% (minimum 99%, Missing); lung: 97.7273% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 94.1606% (minimum 99%, Missing); pancreas: 94.8529% (minimum 99%, Missing); parathyroid gland: 94.8529% (minimum 97%, Missing); pituitary gland: 94.8529% (minimum 99%, Missing); rectum: 77.2455% (minimum 97%, Missing); retina: 87.1622% (minimum 99%, Missing); salivary gland: 94.8529% (minimum 97%, Missing); skeletal muscle: 96.9925% (minimum 99%, Missing); small intestine: 87.7551% (minimum 99%, Missing); smooth muscle: 92.8058% (minimum 99%, Missing); spinal cord: 98.4733% (minimum 99%, Missing); spleen: 87.1622% (minimum 95%, Missing); stomach: 93.4783% (minimum 97%, Missing); thymus: 60.0000% (minimum 95%, Missing); thyroid gland: 88.3562% (minimum 95%, Missing); urinary bladder: 93.4783% (minimum 97%, Missing)",0,80,unavailable,15.1,4.3,8.6,"bone marrow: 15.1 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); rectum: 3.8 nTPM (protected, limit 2); colon: 3.4 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164045,CDC25A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.35,-0.22,-0.529286
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,26.1,13.3,8.2,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 12); kidney: 12.9 nTPM (vital, limit 6); adrenal gland: 10.9 nTPM (vital, limit 6); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); cerebral cortex: 8.2 nTPM (vital, limit 6); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 6); heart muscle: 6.2 nTPM (vital, limit 6); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); spinal cord: 3.1 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164070,HSPA4L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.6438% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7389% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.0495% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.2376% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.7129% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.7944% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.8760% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.8684% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.8141% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.4544% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.8261% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.1139% (minimum 99%, Baseline (adaptation disabled)); liver: 93.6170% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5994% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.5389% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.4384% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.7216% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.1217% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.8807% (minimum 97%, Baseline (adaptation disabled)); retina: 80.1822% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0495% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.5994% (minimum 99%, Baseline (adaptation disabled)); skin: 92.7944% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.8764% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.3272% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1481% (minimum 99%, Baseline (adaptation disabled)); tongue: 96.8807% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,26.1,13.3,8.2,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 2); kidney: 12.9 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); cerebral cortex: 8.2 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); spinal cord: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164070,HSPA4L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0220562,-0.0818587,-0.188178
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.6438% (minimum 95%, Enhanced); amygdala: 95.7389% (minimum 99%, Missing); basal ganglia: 95.0495% (minimum 99%, Missing); cerebellum: 92.7129% (minimum 99%, Missing); cerebral cortex: 92.7944% (minimum 95%, Enhanced); choroid plexus: 92.8760% (minimum 99%, Missing); heart muscle: 94.4544% (minimum 95%, Enhanced); hippocampal formation: 96.0000% (minimum 99%, Missing); hypothalamus: 91.8261% (minimum 99%, Missing); kidney: 89.1139% (minimum 95%, Enhanced); liver: 93.6170% (minimum 95%, Enhanced); lung: 98.5994% (minimum 99%, Missing); midbrain: 94.5389% (minimum 99%, Missing); pituitary gland: 93.1217% (minimum 99%, Missing); retina: 80.1822% (minimum 99%, Missing); spinal cord: 97.1481% (minimum 99%, Missing); tongue: 96.8807% (minimum 97%, Missing)",0,5,partial,26.1,13.3,8.2,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 12); kidney: 12.9 nTPM (vital, limit 6); adrenal gland: 10.9 nTPM (vital, limit 6); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); cerebral cortex: 8.2 nTPM (vital, limit 6); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 6); heart muscle: 6.2 nTPM (vital, limit 6); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); spinal cord: 3.1 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164070,HSPA4L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0143836,-0.00119266,-0.188178
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000164113,ADAD1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000164113,ADAD1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0482729,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000164113,ADAD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0482729,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.5,0,0.1,,,0,not_established,not_triggered,,,ENSG00000164123,SPMIP2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 95.3704% (minimum 99%, Baseline (adaptation disabled)); retina: 98.0952% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0,0.1,,,0,not_established,not_triggered,,,ENSG00000164123,SPMIP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0403846,0.03,-0.0362963
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 95.3704% (minimum 99%, Missing); retina: 98.0952% (minimum 99%, Missing)",0,80,unavailable,0.5,0,0.1,,,0,not_established,not_triggered,,,ENSG00000164123,SPMIP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0403846,0.03,-0.0362963
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.2,0.2,1,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164175,SLC45A2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.9091% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.9091% (minimum 99%, Baseline (adaptation disabled)); colon: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.9231% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.4286% (minimum 99%, Baseline (adaptation disabled)); liver: 45.4545% (minimum 99%, Baseline (adaptation disabled)); midbrain: 90.9091% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.9091% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 71.4286% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 90.9091% (minimum 99%, Baseline (adaptation disabled)); skin: 50.0000% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 83.3333% (minimum 99%, Baseline (adaptation disabled)); stomach: 83.3333% (minimum 97%, Baseline (adaptation disabled)); tongue: 90.9091% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.2,0.2,1,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164175,SLC45A2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.136667,-0.535455
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.9091% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); cerebellum: 83.3333% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 99%, Missing); colon: 83.3333% (minimum 97%, Missing); heart muscle: 76.9231% (minimum 99%, Missing); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 83.3333% (minimum 99%, Missing); kidney: 71.4286% (minimum 99%, Missing); liver: 45.4545% (minimum 99%, Missing); midbrain: 90.9091% (minimum 99%, Missing); pituitary gland: 90.9091% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 71.4286% (minimum 99%, Missing); skeletal muscle: 90.9091% (minimum 99%, Missing); skin: 50.0000% (minimum 95%, Missing); spinal cord: 83.3333% (minimum 99%, Missing); stomach: 83.3333% (minimum 97%, Missing); tongue: 90.9091% (minimum 97%, Missing)",0,80,unavailable,1.2,0.2,1,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164175,SLC45A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.136667,-0.535455
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.8,3.6,2.2,"retina: 4.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164220,F2RL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.2439% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.0952% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.8718% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.3684% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.3684% (minimum 99%, Baseline (adaptation disabled)); colon: 52.1127% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.8113% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.2222% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.5185% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.5185% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 66.0714% (minimum 99%, Baseline (adaptation disabled)); lung: 88.0952% (minimum 99%, Baseline (adaptation disabled)); midbrain: 58.7302% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.7234% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.8718% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.5000% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.8113% (minimum 97%, Baseline (adaptation disabled)); retina: 43.5294% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.6849% (minimum 97%, Baseline (adaptation disabled)); skin: 62.7119% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.7119% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 50.6849% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.3684% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.0909% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.8718% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.0952% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.4348% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.8,3.6,2.2,"retina: 4.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164220,F2RL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.322881,-0.463151,-0.554706
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.5000% (minimum 95%, Missing); adrenal gland: 90.2439% (minimum 99%, Missing); basal ganglia: 88.0952% (minimum 99%, Missing); bone marrow: 94.8718% (minimum 99%, Missing); cerebral cortex: 97.3684% (minimum 99%, Missing); choroid plexus: 97.3684% (minimum 99%, Missing); colon: 52.1127% (minimum 97%, Missing); duodenum: 69.8113% (minimum 99%, Missing); esophagus: 82.2222% (minimum 97%, Missing); heart muscle: 68.5185% (minimum 99%, Missing); hypothalamus: 68.5185% (minimum 99%, Missing); kidney: 92.5000% (minimum 99%, Missing); liver: 66.0714% (minimum 99%, Missing); lung: 88.0952% (minimum 99%, Missing); midbrain: 58.7302% (minimum 99%, Missing); pancreas: 78.7234% (minimum 99%, Missing); parathyroid gland: 94.8718% (minimum 97%, Missing); pituitary gland: 92.5000% (minimum 99%, Missing); rectum: 69.8113% (minimum 97%, Missing); retina: 43.5294% (minimum 99%, Missing); salivary gland: 50.6849% (minimum 97%, Missing); skin: 62.7119% (minimum 95%, Missing); small intestine: 62.7119% (minimum 99%, Missing); smooth muscle: 50.6849% (minimum 99%, Missing); spinal cord: 97.3684% (minimum 99%, Missing); spleen: 92.5000% (minimum 95%, Missing); stomach: 74.0000% (minimum 97%, Missing); thymus: 84.0909% (minimum 95%, Missing); thyroid gland: 94.8718% (minimum 95%, Missing); tongue: 88.0952% (minimum 97%, Missing); urinary bladder: 80.4348% (minimum 97%, Missing)",0,80,unavailable,4.8,3.6,2.2,"retina: 4.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164220,F2RL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.322881,-0.463151,-0.554706
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12.7,11.5,8.6,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 2); thyroid gland: 8.6 nTPM (manageable, limit 5); lymph node: 8 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); pituitary gland: 6.7 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 2); salivary gland: 4.4 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164241,C5orf63,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 81.0811% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.5369% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.5070% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.7586% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.4194% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.7143% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.7143% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 71.8563% (minimum 99%, Baseline (adaptation disabled)); colon: 64.1711% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.5714% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.9655% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.8649% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.3309% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.4702% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.0391% (minimum 99%, Baseline (adaptation disabled)); liver: 70.1754% (minimum 99%, Baseline (adaptation disabled)); lung: 76.4331% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.4702% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.1754% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 67.4157% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.1711% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.0638% (minimum 97%, Baseline (adaptation disabled)); retina: 48.5830% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.1707% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.0059% (minimum 99%, Baseline (adaptation disabled)); skin: 75.9494% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.2983% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.9565% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.8557% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.7674% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.2524% (minimum 95%, Baseline (adaptation disabled)); tongue: 72.2892% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.4717% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,12.7,11.5,8.6,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 2); thyroid gland: 8.6 nTPM (manageable, limit 5); lymph node: 8 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); pituitary gland: 6.7 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 2); salivary gland: 4.4 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164241,C5orf63,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.367476,-0.459362,-0.50417
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 81.0811% (minimum 95%, Missing); adrenal gland: 80.5369% (minimum 99%, Missing); amygdala: 84.5070% (minimum 99%, Missing); basal ganglia: 82.7586% (minimum 99%, Missing); bone marrow: 77.4194% (minimum 99%, Missing); cerebellum: 85.7143% (minimum 99%, Missing); cerebral cortex: 85.7143% (minimum 99%, Missing); choroid plexus: 71.8563% (minimum 99%, Missing); colon: 64.1711% (minimum 97%, Missing); duodenum: 68.5714% (minimum 99%, Missing); esophagus: 68.9655% (minimum 97%, Missing); heart muscle: 64.8649% (minimum 99%, Missing); hippocampal formation: 86.3309% (minimum 99%, Missing); hypothalamus: 79.4702% (minimum 99%, Missing); kidney: 67.0391% (minimum 99%, Missing); liver: 70.1754% (minimum 99%, Missing); lung: 76.4331% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 79.4702% (minimum 99%, Missing); pancreas: 70.1754% (minimum 99%, Missing); parathyroid gland: 67.4157% (minimum 97%, Missing); pituitary gland: 64.1711% (minimum 99%, Missing); rectum: 51.0638% (minimum 97%, Missing); retina: 48.5830% (minimum 99%, Missing); salivary gland: 73.1707% (minimum 97%, Missing); skeletal muscle: 71.0059% (minimum 99%, Missing); skin: 75.9494% (minimum 95%, Missing); small intestine: 66.2983% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spinal cord: 86.9565% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 61.8557% (minimum 97%, Missing); thymus: 69.7674% (minimum 95%, Missing); thyroid gland: 58.2524% (minimum 95%, Missing); tongue: 72.2892% (minimum 97%, Missing); urinary bladder: 75.4717% (minimum 97%, Missing)",0,80,unavailable,12.7,11.5,8.6,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 2); thyroid gland: 8.6 nTPM (manageable, limit 5); lymph node: 8 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); pituitary gland: 6.7 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 2); salivary gland: 4.4 nTPM (protected, limit 2); urinary bladder: 3.9 nTPM (protected, limit 2); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164241,C5orf63,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.367476,-0.459362,-0.50417
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164256,PRDM9,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.5000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164256,PRDM9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.00121951,0.03,-0.015
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.5000% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164256,PRDM9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.00121951,0.03,-0.015
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0,0,"kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000164287,CDC20B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 89.2857% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.4444% (minimum 99%, Baseline (adaptation disabled)); lung: 86.2069% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0,0,"kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000164287,CDC20B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.03,-0.295556
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 89.2857% (minimum 99%, Missing); kidney: 69.4444% (minimum 99%, Missing); lung: 86.2069% (minimum 99%, Missing)",0,80,unavailable,1.1,0,0,"kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000164287,CDC20B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.03,-0.295556
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000164299,SPZ1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000164299,SPZ1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000164299,SPZ1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000164304,CAGE1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.0784% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000164304,CAGE1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0292157
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.0784% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000164304,CAGE1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0292157
True,compatible,,True,True,False,,0,4,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164334,FAM170A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.5816% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164334,FAM170A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0428571,0.03,-0.0041844
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.5816% (minimum 99%, Missing)",0,4,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164334,FAM170A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0041844
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000164399,IL3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 25.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000164399,IL3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.74
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 25.0000% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000164399,IL3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.74
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,1.6,1,1,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164404,GDF9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.5484% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.7755% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.4660% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.5652% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.7755% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.6044% (minimum 99%, Baseline (adaptation disabled)); colon: 96.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.6044% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.6907% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.8788% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.1386% (minimum 99%, Baseline (adaptation disabled)); liver: 93.5484% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7528% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.6044% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.7755% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.6907% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.5484% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.4660% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 87.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.5789% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.5532% (minimum 99%, Baseline (adaptation disabled)); skin: 89.6907% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.6044% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.7528% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.6250% (minimum 99%, Baseline (adaptation disabled)); stomach: 89.6907% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.5532% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.6250% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.5484% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.5652% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,1.6,1,1,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164404,GDF9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0530928,-0.0730928,-0.14534
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.5484% (minimum 97%, Supported); amygdala: 88.7755% (minimum 99%, Missing); basal ganglia: 84.4660% (minimum 99%, Missing); bone marrow: 96.6667% (minimum 97%, Supported); cerebellum: 94.5652% (minimum 97%, Supported); cerebral cortex: 88.7755% (minimum 97%, Supported); choroid plexus: 95.6044% (minimum 99%, Missing); duodenum: 95.6044% (minimum 97%, Supported); heart muscle: 96.6667% (minimum 97%, Supported); hippocampal formation: 89.6907% (minimum 99%, Missing); hypothalamus: 87.8788% (minimum 99%, Missing); kidney: 86.1386% (minimum 97%, Supported); liver: 93.5484% (minimum 97%, Supported); midbrain: 88.7755% (minimum 99%, Missing); pancreas: 89.6907% (minimum 97%, Supported); pituitary gland: 84.4660% (minimum 99%, Missing); retina: 87.0000% (minimum 99%, Missing); skeletal muscle: 92.5532% (minimum 97%, Supported); small intestine: 95.6044% (minimum 97%, Supported); spinal cord: 90.6250% (minimum 99%, Missing); stomach: 89.6907% (minimum 90%, Supported); thymus: 92.5532% (minimum 95%, Missing); tongue: 93.5484% (minimum 97%, Missing)",0,1,partial,1.6,1,1,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164404,GDF9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0244681,-0.0345161,-0.14534
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,36.4,46.1,24.2,"rectum: 46.1 nTPM (protected, limit 2); colon: 38.3 nTPM (protected, limit 2); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); salivary gland: 30.7 nTPM (protected, limit 2); stomach: 28.5 nTPM (protected, limit 2); skin: 24.2 nTPM (manageable, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 2); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 2); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); basal ganglia: 18.9 nTPM (vital, limit 1); spleen: 18.5 nTPM (manageable, limit 5); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 2); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (manageable, limit 5); thymus: 15.8 nTPM (manageable, limit 5); adipose tissue: 15.8 nTPM (manageable, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); tongue: 15 nTPM (protected, limit 2); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 2); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164414,SLC35A1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.2008% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.4770% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.1078% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.2574% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.1803% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.5445% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.3902% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 50.4979% (minimum 99%, Baseline (adaptation disabled)); colon: 48.1030% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.1080% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.4490% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.6078% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.9640% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.2313% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.5063% (minimum 99%, Baseline (adaptation disabled)); liver: 52.7489% (minimum 99%, Baseline (adaptation disabled)); lung: 49.3741% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.9811% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.8583% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.8819% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.7877% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 65.8627% (minimum 99%, Baseline (adaptation disabled)); rectum: 43.5049% (minimum 97%, Baseline (adaptation disabled)); retina: 71.7172% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.6254% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 72.7459% (minimum 99%, Baseline (adaptation disabled)); skin: 59.4640% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.9433% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.7446% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.7407% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.4688% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.2008% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.4008% (minimum 95%, Baseline (adaptation disabled)); tongue: 70.2970% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.0551% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,36.4,46.1,24.2,"rectum: 46.1 nTPM (protected, limit 2); colon: 38.3 nTPM (protected, limit 2); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); salivary gland: 30.7 nTPM (protected, limit 2); stomach: 28.5 nTPM (protected, limit 2); skin: 24.2 nTPM (manageable, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 2); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 2); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); basal ganglia: 18.9 nTPM (vital, limit 1); spleen: 18.5 nTPM (manageable, limit 5); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 2); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (manageable, limit 5); thymus: 15.8 nTPM (manageable, limit 5); adipose tissue: 15.8 nTPM (manageable, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); tongue: 15 nTPM (protected, limit 2); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 2); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164414,SLC35A1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.35536,-0.534951,-0.496259
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.2008% (minimum 95%, Missing); adrenal gland: 60.4770% (minimum 99%, Missing); amygdala: 67.1078% (minimum 99%, Missing); basal ganglia: 65.2574% (minimum 99%, Missing); bone marrow: 76.1803% (minimum 99%, Missing); cerebellum: 53.5445% (minimum 99%, Missing); cerebral cortex: 62.3902% (minimum 99%, Missing); choroid plexus: 50.4979% (minimum 99%, Missing); colon: 48.1030% (minimum 97%, Missing); duodenum: 66.1080% (minimum 99%, Missing); esophagus: 72.4490% (minimum 97%, Missing); heart muscle: 69.6078% (minimum 99%, Missing); hippocampal formation: 63.9640% (minimum 99%, Missing); hypothalamus: 66.2313% (minimum 99%, Missing); kidney: 63.5063% (minimum 99%, Missing); liver: 52.7489% (minimum 99%, Missing); lung: 49.3741% (minimum 99%, Missing); lymph node: 66.9811% (minimum 97%, Missing); midbrain: 70.8583% (minimum 99%, Missing); pancreas: 69.8819% (minimum 99%, Missing); parathyroid gland: 60.7877% (minimum 97%, Missing); pituitary gland: 65.8627% (minimum 99%, Missing); rectum: 43.5049% (minimum 97%, Missing); retina: 71.7172% (minimum 99%, Missing); salivary gland: 53.6254% (minimum 97%, Missing); skeletal muscle: 72.7459% (minimum 99%, Missing); skin: 59.4640% (minimum 95%, Missing); small intestine: 62.9433% (minimum 99%, Missing); smooth muscle: 62.5000% (minimum 99%, Missing); spinal cord: 69.7446% (minimum 99%, Missing); spleen: 65.7407% (minimum 95%, Missing); stomach: 55.4688% (minimum 97%, Missing); thymus: 69.2008% (minimum 95%, Missing); thyroid gland: 68.4008% (minimum 95%, Missing); tongue: 70.2970% (minimum 97%, Missing); urinary bladder: 63.0551% (minimum 97%, Missing)",0,80,unavailable,36.4,46.1,24.2,"rectum: 46.1 nTPM (protected, limit 2); colon: 38.3 nTPM (protected, limit 2); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); salivary gland: 30.7 nTPM (protected, limit 2); stomach: 28.5 nTPM (protected, limit 2); skin: 24.2 nTPM (manageable, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 2); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 2); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); basal ganglia: 18.9 nTPM (vital, limit 1); spleen: 18.5 nTPM (manageable, limit 5); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 2); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (manageable, limit 5); thymus: 15.8 nTPM (manageable, limit 5); adipose tissue: 15.8 nTPM (manageable, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); tongue: 15 nTPM (protected, limit 2); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 2); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164414,SLC35A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.35536,-0.534951,-0.496259
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.2,0.3,3.9,"choroid plexus: 3.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164451,CALHM4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 87.5486% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.6842% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.6842% (minimum 99%, Baseline (adaptation disabled)); skin: 85.2273% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.2,0.3,3.9,"choroid plexus: 3.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164451,CALHM4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0977273,0.0168421,-0.114514
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 87.5486% (minimum 99%, Missing); heart muscle: 98.6842% (minimum 99%, Missing); skeletal muscle: 98.6842% (minimum 99%, Missing); skin: 85.2273% (minimum 95%, Missing)",0,80,unavailable,3.2,0.3,3.9,"choroid plexus: 3.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000164451,CALHM4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0977273,0.0168421,-0.114514
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.7,10.1,9,"lymph node: 10.1 nTPM (protected, limit 2); spleen: 9 nTPM (manageable, limit 5); thymus: 6.1 nTPM (manageable, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164483,SAMD3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.6250% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.2453% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 50.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.4545% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.3617% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 77.7778% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.7143% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.7143% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.3617% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.6364% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.4138% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.2453% (minimum 99%, Baseline (adaptation disabled)); liver: 71.1864% (minimum 99%, Baseline (adaptation disabled)); lung: 56.7568% (minimum 99%, Baseline (adaptation disabled)); lymph node: 29.3706% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.3617% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.2453% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 47.1910% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.6250% (minimum 97%, Baseline (adaptation disabled)); retina: 76.3636% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.7143% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 89.3617% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.1864% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.5000% (minimum 99%, Baseline (adaptation disabled)); spleen: 31.8182% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.4138% (minimum 97%, Baseline (adaptation disabled)); thymus: 40.7767% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 85.7143% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.3636% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.7,10.1,9,"lymph node: 10.1 nTPM (protected, limit 2); spleen: 9 nTPM (manageable, limit 5); thymus: 6.1 nTPM (manageable, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164483,SAMD3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.631818,-0.676294,-0.51809
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Missing); adrenal gland: 65.6250% (minimum 99%, Missing); amygdala: 79.2453% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); bone marrow: 50.0000% (minimum 99%, Missing); cerebellum: 95.4545% (minimum 99%, Missing); cerebral cortex: 89.3617% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 77.7778% (minimum 97%, Missing); duodenum: 85.7143% (minimum 99%, Missing); esophagus: 85.7143% (minimum 97%, Missing); heart muscle: 89.3617% (minimum 99%, Missing); hippocampal formation: 63.6364% (minimum 99%, Missing); hypothalamus: 72.4138% (minimum 99%, Missing); kidney: 79.2453% (minimum 99%, Missing); liver: 71.1864% (minimum 99%, Missing); lung: 56.7568% (minimum 99%, Missing); lymph node: 29.3706% (minimum 97%, Missing); midbrain: 89.3617% (minimum 99%, Missing); pancreas: 79.2453% (minimum 99%, Missing); pituitary gland: 47.1910% (minimum 99%, Missing); rectum: 65.6250% (minimum 97%, Missing); retina: 76.3636% (minimum 99%, Missing); salivary gland: 85.7143% (minimum 97%, Missing); skeletal muscle: 84.0000% (minimum 99%, Missing); skin: 89.3617% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 71.1864% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 31.8182% (minimum 95%, Missing); stomach: 72.4138% (minimum 97%, Missing); thymus: 40.7767% (minimum 95%, Missing); thyroid gland: 84.0000% (minimum 95%, Missing); tongue: 85.7143% (minimum 97%, Missing); urinary bladder: 76.3636% (minimum 97%, Missing)",0,80,unavailable,4.7,10.1,9,"lymph node: 10.1 nTPM (protected, limit 2); spleen: 9 nTPM (manageable, limit 5); thymus: 6.1 nTPM (manageable, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164483,SAMD3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.631818,-0.676294,-0.51809
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,ENSG00000164500,SPMIP7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.6744% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3333% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.6744% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.6744% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,ENSG00000164500,SPMIP7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.00674419,-0.0566667
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.6744% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); duodenum: 97.6744% (minimum 99%, Missing); pituitary gland: 97.6744% (minimum 99%, Missing)",0,80,unavailable,0.3,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,ENSG00000164500,SPMIP7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.00674419,-0.0566667
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,9,partial,9.6,36.8,9.6,"parathyroid gland: 36.8 nTPM (protected, limit 2); cerebral cortex: 9.6 nTPM (vital, limit 1); skin: 9.6 nTPM (manageable, limit 5); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 6); colon: 6.5 nTPM (protected, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); retina: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); salivary gland: 4.8 nTPM (protected, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); hypothalamus: 4.2 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2); duodenum: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164506,STXBP5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.9688% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 55.0633% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.7288% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.7288% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.4122% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.8764% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 47.5410% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7528% (minimum 99%, Baseline (adaptation disabled)); colon: 57.2368% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.1613% (minimum 99%, Baseline (adaptation disabled)); esophagus: 50.5814% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.9008% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.7317% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.4419% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.6538% (minimum 99%, Baseline (adaptation disabled)); liver: 84.4660% (minimum 99%, Baseline (adaptation disabled)); lung: 71.3115% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.1613% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.3590% (minimum 99%, Baseline (adaptation disabled)); pancreas: 50.5814% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 19.1209% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.2368% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.5036% (minimum 97%, Baseline (adaptation disabled)); retina: 63.0435% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.4444% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.0633% (minimum 99%, Baseline (adaptation disabled)); skin: 47.5410% (minimum 95%, Baseline (adaptation disabled)); small intestine: 53.0488% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.9912% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.6522% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.5039% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.9008% (minimum 97%, Baseline (adaptation disabled)); thymus: 79.0909% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 69.6000% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.5039% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.4419% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,9.6,36.8,9.6,"parathyroid gland: 36.8 nTPM (protected, limit 2); cerebral cortex: 9.6 nTPM (vital, limit 1); skin: 9.6 nTPM (manageable, limit 5); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); retina: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); salivary gland: 4.8 nTPM (protected, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); hypothalamus: 4.2 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2); duodenum: 3.7 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164506,STXBP5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.47459,-0.778791,-0.51459
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.0633% (minimum 99%, Missing); amygdala: 73.7288% (minimum 99%, Missing); basal ganglia: 73.7288% (minimum 99%, Missing); bone marrow: 66.4122% (minimum 99%, Missing); cerebellum: 48.8764% (minimum 99%, Missing); cerebral cortex: 47.5410% (minimum 99%, Missing); choroid plexus: 97.7528% (minimum 99%, Missing); colon: 57.2368% (minimum 97%, Missing); duodenum: 70.1613% (minimum 99%, Missing); esophagus: 50.5814% (minimum 97%, Missing); heart muscle: 71.9008% (minimum 95%, Enhanced); hippocampal formation: 70.7317% (minimum 99%, Missing); hypothalamus: 67.4419% (minimum 99%, Missing); kidney: 83.6538% (minimum 99%, Missing); liver: 84.4660% (minimum 99%, Missing); lung: 71.3115% (minimum 99%, Missing); lymph node: 70.1613% (minimum 80%, Enhanced); midbrain: 74.3590% (minimum 99%, Missing); pancreas: 50.5814% (minimum 99%, Missing); parathyroid gland: 19.1209% (minimum 97%, Missing); pituitary gland: 57.2368% (minimum 99%, Missing); rectum: 63.5036% (minimum 97%, Missing); retina: 63.0435% (minimum 99%, Missing); salivary gland: 64.4444% (minimum 97%, Missing); skeletal muscle: 55.0633% (minimum 95%, Enhanced); skin: 47.5410% (minimum 95%, Missing); small intestine: 53.0488% (minimum 99%, Missing); smooth muscle: 76.9912% (minimum 95%, Enhanced); spinal cord: 75.6522% (minimum 99%, Missing); stomach: 71.9008% (minimum 97%, Missing); thymus: 79.0909% (minimum 95%, Missing); thyroid gland: 69.6000% (minimum 95%, Missing); tongue: 68.5039% (minimum 97%, Missing); urinary bladder: 67.4419% (minimum 97%, Missing)",0,9,partial,9.6,36.8,9.6,"parathyroid gland: 36.8 nTPM (protected, limit 2); cerebral cortex: 9.6 nTPM (vital, limit 1); skin: 9.6 nTPM (manageable, limit 5); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 6); colon: 6.5 nTPM (protected, limit 2); pituitary gland: 6.5 nTPM (vital, limit 1); retina: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 2); salivary gland: 4.8 nTPM (protected, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); hypothalamus: 4.2 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2); duodenum: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164506,STXBP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.47459,-0.778791,-0.51459
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,False,,0,2,partial,0.3,0,0,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164508,H2AC1,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"kidney: 96.4912% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.8276% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.3,0,0,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164508,H2AC1,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,0.05,0.03,-0.0417241
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"kidney: 96.4912% (minimum 99%, Missing); liver: 98.2143% (minimum 99%, Missing); pancreas: 94.8276% (minimum 99%, Missing)",0,2,partial,0.3,0,0,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164508,H2AC1,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,0.05,0.03,-0.0417241
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,3.8,3.5,3.1,"hypothalamus: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000164512,ANKRD55,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.9691% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.0734% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.6885% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.2039% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.9592% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.0734% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9691% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9691% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.9691% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.3077% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.6418% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 76.1905% (minimum 99%, Baseline (adaptation disabled)); lung: 96.9697% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.2824% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.5660% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.9592% (minimum 99%, Baseline (adaptation disabled)); retina: 96.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.5660% (minimum 97%, Baseline (adaptation disabled)); small intestine: 88.0734% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.9691% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.4286% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.7143% (minimum 95%, Baseline (adaptation disabled)); thymus: 75.5906% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.9697% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,3.8,3.5,3.1,"hypothalamus: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000164512,ANKRD55,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.194094,-0.237176,-0.273582
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.9691% (minimum 99%, Uncertain); amygdala: 88.0734% (minimum 99%, Missing); basal ganglia: 78.6885% (minimum 99%, Missing); bone marrow: 93.2039% (minimum 99%, Missing); cerebellum: 97.9592% (minimum 99%, Missing); cerebral cortex: 88.0734% (minimum 99%, Missing); choroid plexus: 98.9691% (minimum 99%, Missing); duodenum: 98.9691% (minimum 99%, Missing); heart muscle: 98.9691% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); hypothalamus: 71.6418% (minimum 99%, Missing); kidney: 96.0000% (minimum 99%, Missing); liver: 76.1905% (minimum 99%, Missing); lung: 96.9697% (minimum 99%, Missing); lymph node: 73.2824% (minimum 97%, Missing); midbrain: 90.5660% (minimum 99%, Missing); pituitary gland: 97.9592% (minimum 99%, Missing); retina: 96.0000% (minimum 99%, Missing); salivary gland: 90.5660% (minimum 97%, Missing); small intestine: 88.0734% (minimum 99%, Missing); smooth muscle: 98.9691% (minimum 99%, Uncertain); spinal cord: 91.4286% (minimum 99%, Missing); spleen: 85.7143% (minimum 95%, Missing); thymus: 75.5906% (minimum 95%, Missing); urinary bladder: 96.9697% (minimum 97%, Missing)",0,2,partial,3.8,3.5,3.1,"hypothalamus: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000164512,ANKRD55,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.194094,-0.237176,-0.273582
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,17.4,11.3,5.6,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 2); stomach: 10.8 nTPM (protected, limit 2); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); bone marrow: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164542,MATCAP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.4694% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.4427% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.3846% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.2030% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.1429% (minimum 99%, Baseline (adaptation disabled)); colon: 90.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.7039% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.3766% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.7039% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.3755% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.1209% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.0526% (minimum 99%, Baseline (adaptation disabled)); liver: 80.2974% (minimum 99%, Baseline (adaptation disabled)); lung: 88.1633% (minimum 99%, Baseline (adaptation disabled)); midbrain: 88.8889% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.0526% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.6535% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.6978% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.7368% (minimum 97%, Baseline (adaptation disabled)); retina: 59.8338% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.8889% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.5065% (minimum 99%, Baseline (adaptation disabled)); skin: 79.4118% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.1542% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.5246% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.0558% (minimum 99%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 87.4494% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.0558% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.9130% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.7368% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,17.4,11.3,5.6,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 2); stomach: 10.8 nTPM (protected, limit 2); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); bone marrow: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164542,MATCAP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.155882,-0.313465,-0.436154
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.4694% (minimum 99%, Missing); amygdala: 85.7143% (minimum 99%, Missing); basal ganglia: 82.4427% (minimum 99%, Missing); bone marrow: 90.0000% (minimum 99%, Missing); cerebellum: 55.3846% (minimum 99%, Missing); cerebral cortex: 81.2030% (minimum 99%, Missing); choroid plexus: 77.1429% (minimum 99%, Missing); colon: 90.0000% (minimum 97%, Missing); duodenum: 92.7039% (minimum 99%, Missing); esophagus: 90.3766% (minimum 97%, Missing); heart muscle: 92.7039% (minimum 99%, Missing); hippocampal formation: 85.3755% (minimum 99%, Missing); hypothalamus: 79.1209% (minimum 99%, Missing); kidney: 71.0526% (minimum 99%, Missing); liver: 80.2974% (minimum 99%, Missing); lung: 88.1633% (minimum 99%, Missing); midbrain: 88.8889% (minimum 99%, Missing); pancreas: 71.0526% (minimum 99%, Missing); parathyroid gland: 65.6535% (minimum 97%, Missing); pituitary gland: 77.6978% (minimum 99%, Missing); rectum: 94.7368% (minimum 97%, Missing); retina: 59.8338% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); skeletal muscle: 93.5065% (minimum 99%, Missing); skin: 79.4118% (minimum 95%, Missing); small intestine: 95.1542% (minimum 99%, Missing); smooth muscle: 88.5246% (minimum 99%, Missing); spinal cord: 86.0558% (minimum 99%, Missing); stomach: 66.6667% (minimum 97%, Missing); thymus: 87.4494% (minimum 95%, Missing); thyroid gland: 86.0558% (minimum 95%, Missing); tongue: 93.9130% (minimum 97%, Missing); urinary bladder: 94.7368% (minimum 97%, Missing)",0,80,unavailable,17.4,11.3,5.6,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 2); stomach: 10.8 nTPM (protected, limit 2); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); bone marrow: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164542,MATCAP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.155882,-0.313465,-0.436154
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,False,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000164556,CFAP144P1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000164556,CFAP144P1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000164556,CFAP144P1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,157.9,79.5,123.6,"bone marrow: 157.9 nTPM (vital, limit 1); thymus: 123.6 nTPM (manageable, limit 5); lymph node: 79.5 nTPM (protected, limit 2); thyroid gland: 76.9 nTPM (manageable, limit 30); esophagus: 58 nTPM (protected, limit 2); rectum: 42.6 nTPM (protected, limit 2); skin: 35 nTPM (manageable, limit 5); colon: 32.7 nTPM (protected, limit 2); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 6); spleen: 18.2 nTPM (manageable, limit 5); urinary bladder: 12.1 nTPM (protected, limit 12); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); lung: 8.4 nTPM (vital, limit 6); cerebral cortex: 7.8 nTPM (vital, limit 6); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164611,PTTG1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.0426% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.4814% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.7818% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 51.8891% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.3256% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.6204% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.2968% (minimum 99%, Baseline (adaptation disabled)); colon: 83.8916% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.6931% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.5948% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.0426% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.9845% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.3235% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.3256% (minimum 99%, Baseline (adaptation disabled)); liver: 97.0924% (minimum 99%, Baseline (adaptation disabled)); lung: 95.2994% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.1745% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.1556% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.5931% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.9906% (minimum 97%, Baseline (adaptation disabled)); retina: 98.6674% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.4537% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.6103% (minimum 99%, Baseline (adaptation disabled)); skin: 82.9518% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.9195% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.2013% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.6674% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.3448% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.6744% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.9449% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.8916% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.3662% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,157.9,79.5,123.6,"bone marrow: 157.9 nTPM (vital, limit 1); thymus: 123.6 nTPM (manageable, limit 5); lymph node: 79.5 nTPM (protected, limit 2); thyroid gland: 76.9 nTPM (manageable, limit 5); esophagus: 58 nTPM (protected, limit 2); rectum: 42.6 nTPM (protected, limit 2); skin: 35 nTPM (manageable, limit 5); colon: 32.7 nTPM (protected, limit 2); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); urinary bladder: 12.1 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 2); lung: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164611,PTTG1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.370551,-0.288255,-0.471109
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.4814% (minimum 99%, Missing); basal ganglia: 95.7818% (minimum 99%, Missing); bone marrow: 51.8891% (minimum 99%, Missing); choroid plexus: 94.2968% (minimum 99%, Missing); colon: 83.8916% (minimum 97%, Missing); duodenum: 87.6931% (minimum 99%, Missing); esophagus: 74.5948% (minimum 97%, Missing); hippocampal formation: 93.9845% (minimum 99%, Missing); hypothalamus: 96.3235% (minimum 99%, Missing); liver: 97.0924% (minimum 99%, Missing); lymph node: 68.1745% (minimum 97%, Missing); midbrain: 98.1556% (minimum 99%, Missing); pituitary gland: 97.5931% (minimum 99%, Missing); rectum: 79.9906% (minimum 97%, Missing); retina: 98.6674% (minimum 99%, Missing); skin: 82.9518% (minimum 95%, Missing); small intestine: 87.9195% (minimum 99%, Missing); smooth muscle: 90.2013% (minimum 95%, Enhanced); spinal cord: 98.6674% (minimum 99%, Missing); spleen: 90.3448% (minimum 95%, Missing); thymus: 57.9449% (minimum 95%, Missing)",0,5,partial,157.9,79.5,123.6,"bone marrow: 157.9 nTPM (vital, limit 1); thymus: 123.6 nTPM (manageable, limit 5); lymph node: 79.5 nTPM (protected, limit 2); thyroid gland: 76.9 nTPM (manageable, limit 30); esophagus: 58 nTPM (protected, limit 2); rectum: 42.6 nTPM (protected, limit 2); skin: 35 nTPM (manageable, limit 5); colon: 32.7 nTPM (protected, limit 2); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 6); spleen: 18.2 nTPM (manageable, limit 5); urinary bladder: 12.1 nTPM (protected, limit 12); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); lung: 8.4 nTPM (vital, limit 6); cerebral cortex: 7.8 nTPM (vital, limit 6); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164611,PTTG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.370551,-0.288255,-0.471109
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,8.9,0.3,0.5,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000164627,KIF6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.4444% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.4444% (minimum 99%, Baseline (adaptation disabled)); amygdala: 60.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.4348% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0769% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.6875% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.8333% (minimum 99%, Baseline (adaptation disabled)); colon: 96.2264% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.7273% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.4444% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.4444% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 50.4950% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.4444% (minimum 99%, Baseline (adaptation disabled)); liver: 94.4444% (minimum 99%, Baseline (adaptation disabled)); lung: 87.9310% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.4444% (minimum 97%, Baseline (adaptation disabled)); midbrain: 36.4286% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.7273% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.4444% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.9524% (minimum 99%, Baseline (adaptation disabled)); retina: 63.7500% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 92.7273% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.2264% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.0769% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 40.8000% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.2264% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 91.0714% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.2264% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,8.9,0.3,0.5,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000164627,KIF6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0392857,-0.0255556,-0.625714
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.4444% (minimum 95%, Enhanced); amygdala: 60.0000% (minimum 99%, Missing); basal ganglia: 55.4348% (minimum 99%, Missing); cerebellum: 79.6875% (minimum 95%, Enhanced); cerebral cortex: 56.6667% (minimum 99%, Missing); choroid plexus: 70.8333% (minimum 99%, Missing); duodenum: 92.7273% (minimum 95%, Enhanced); heart muscle: 94.4444% (minimum 95%, Enhanced); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 50.4950% (minimum 99%, Missing); kidney: 94.4444% (minimum 95%, Enhanced); liver: 94.4444% (minimum 95%, Enhanced); lung: 87.9310% (minimum 95%, Enhanced); midbrain: 36.4286% (minimum 99%, Missing); pancreas: 92.7273% (minimum 95%, Enhanced); pituitary gland: 80.9524% (minimum 99%, Missing); retina: 63.7500% (minimum 99%, Missing); skeletal muscle: 92.7273% (minimum 95%, Enhanced); spinal cord: 40.8000% (minimum 99%, Missing); thyroid gland: 91.0714% (minimum 95%, Missing); tongue: 96.2264% (minimum 97%, Missing)",0,7,partial,8.9,0.3,0.5,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000164627,KIF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0392857,-0.00773585,-0.625714
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,not_triggered,,,ENSG00000164645,TEX47,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.1,,,0,not_established,not_triggered,,,ENSG00000164645,TEX47,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0464539,0.03,0.0064539
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.1,,,0,not_established,not_triggered,,,ENSG00000164645,TEX47,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0464539,0.03,0.0064539
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,8.7,2.5,6.8,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164663,USP49,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.5135% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.4937% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.0390% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.9583% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.1193% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 54.6512% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.9286% (minimum 99%, Baseline (adaptation disabled)); colon: 65.2778% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.6032% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.3077% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.1493% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.7500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 57.3171% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.2121% (minimum 99%, Baseline (adaptation disabled)); liver: 74.6032% (minimum 99%, Baseline (adaptation disabled)); lung: 63.5135% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.1972% (minimum 97%, Baseline (adaptation disabled)); midbrain: 65.2778% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.2121% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.0492% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.5135% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.0492% (minimum 97%, Baseline (adaptation disabled)); retina: 35.0746% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.1493% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.5135% (minimum 99%, Baseline (adaptation disabled)); skin: 61.8421% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.4375% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 77.0492% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.2778% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.1972% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.3077% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.7273% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 40.8696% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.4561% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.1972% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,8.7,2.5,6.8,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164663,USP49,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.541304,-0.317222,-0.639254
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6667% (minimum 95%, Uncertain); adrenal gland: 63.5135% (minimum 99%, Missing); amygdala: 59.4937% (minimum 99%, Missing); basal ganglia: 61.0390% (minimum 99%, Missing); bone marrow: 48.9583% (minimum 99%, Missing); cerebellum: 43.1193% (minimum 99%, Missing); cerebral cortex: 54.6512% (minimum 99%, Missing); choroid plexus: 83.9286% (minimum 99%, Missing); colon: 65.2778% (minimum 97%, Missing); duodenum: 74.6032% (minimum 99%, Missing); esophagus: 72.3077% (minimum 97%, Missing); heart muscle: 70.1493% (minimum 99%, Missing); hippocampal formation: 58.7500% (minimum 99%, Missing); hypothalamus: 57.3171% (minimum 99%, Missing); kidney: 71.2121% (minimum 99%, Missing); liver: 74.6032% (minimum 99%, Missing); lung: 63.5135% (minimum 99%, Missing); lymph node: 66.1972% (minimum 97%, Missing); midbrain: 65.2778% (minimum 99%, Missing); pancreas: 71.2121% (minimum 99%, Missing); parathyroid gland: 77.0492% (minimum 97%, Missing); pituitary gland: 63.5135% (minimum 99%, Missing); rectum: 77.0492% (minimum 97%, Missing); retina: 35.0746% (minimum 99%, Missing); salivary gland: 70.1493% (minimum 97%, Missing); skeletal muscle: 63.5135% (minimum 99%, Missing); skin: 61.8421% (minimum 95%, Missing); small intestine: 73.4375% (minimum 99%, Missing); smooth muscle: 77.0492% (minimum 99%, Uncertain); spinal cord: 65.2778% (minimum 99%, Missing); spleen: 66.1972% (minimum 95%, Missing); stomach: 72.3077% (minimum 97%, Missing); thymus: 42.7273% (minimum 95%, Missing); thyroid gland: 40.8696% (minimum 95%, Missing); tongue: 82.4561% (minimum 97%, Missing); urinary bladder: 66.1972% (minimum 97%, Missing)",0,3,partial,8.7,2.5,6.8,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164663,USP49,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.541304,-0.317222,-0.639254
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,1.6,2.9,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000164675,IQUB,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.1873% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.7842% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.3908% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.7842% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.4848% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.8079% (minimum 99%, Baseline (adaptation disabled)); lung: 97.8916% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.3079% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.0149% (minimum 99%, Baseline (adaptation disabled)); retina: 97.0149% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 91.8079% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2.9,1.6,2.9,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000164675,IQUB,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.0319209,-0.0169208,-0.0719209
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.1873% (minimum 99%, Missing); basal ganglia: 98.7842% (minimum 99%, Missing); choroid plexus: 93.3908% (minimum 99%, Missing); hippocampal formation: 98.7842% (minimum 99%, Missing); hypothalamus: 98.4848% (minimum 99%, Missing); kidney: 91.8079% (minimum 99%, Missing); lung: 97.8916% (minimum 99%, Missing); parathyroid gland: 95.3079% (minimum 97%, Missing); pituitary gland: 97.0149% (minimum 99%, Missing); retina: 97.0149% (minimum 99%, Missing); thyroid gland: 91.8079% (minimum 95%, Missing)",0,80,unavailable,2.9,1.6,2.9,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000164675,IQUB,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.0319209,-0.0169208,-0.0719209
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000164729,SLC35G3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skeletal muscle: 95.8333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000164729,SLC35G3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.0316667
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skeletal muscle: 95.8333% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000164729,SLC35G3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.0316667
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,3,partial,0.1,0,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced),52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / keratinocytes,ENSG00000164744,SUN3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,3,partial,0.1,0,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced),52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / keratinocytes,ENSG00000164744,SUN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0475309,0.03,0.00753086
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,3,partial,0.1,0,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced),52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / keratinocytes,ENSG00000164744,SUN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.00753086
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,7.6,0.8,0.2,"choroid plexus: 7.6 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000164746,C7orf57,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.0556% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.7417% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.5294% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.8095% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.3662% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 89.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.0130% (minimum 99%, Baseline (adaptation disabled)); lung: 86.4516% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.5294% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.7143% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.5294% (minimum 99%, Baseline (adaptation disabled)); retina: 96.4029% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1014% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,7.6,0.8,0.2,"choroid plexus: 7.6 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000164746,C7orf57,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0352941,-0.026338,-0.351905
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.0556% (minimum 99%, Missing); basal ganglia: 88.7417% (minimum 99%, Missing); choroid plexus: 63.8095% (minimum 99%, Missing); hippocampal formation: 89.3333% (minimum 99%, Missing); hypothalamus: 87.0130% (minimum 99%, Missing); lung: 86.4516% (minimum 95%, Enhanced); midbrain: 98.5294% (minimum 99%, Missing); pituitary gland: 98.5294% (minimum 99%, Missing); retina: 96.4029% (minimum 99%, Missing); spinal cord: 97.1014% (minimum 99%, Missing)",0,3,partial,7.6,0.8,0.2,"choroid plexus: 7.6 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000164746,C7orf57,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,0.03,-0.351905
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,2.7,0,0.3,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000164796,CSMD3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 34.6154% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 31.0345% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.2857% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 25.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 36.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 30.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 52.9412% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.8182% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 60.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.2857% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2.7,0,0.3,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000164796,CSMD3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.2,0.03,-0.74
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 34.6154% (minimum 99%, Missing); basal ganglia: 31.0345% (minimum 99%, Missing); cerebellum: 64.2857% (minimum 99%, Missing); cerebral cortex: 25.0000% (minimum 99%, Missing); choroid plexus: 90.0000% (minimum 99%, Missing); hippocampal formation: 36.0000% (minimum 99%, Missing); hypothalamus: 30.0000% (minimum 99%, Missing); midbrain: 52.9412% (minimum 99%, Missing); pancreas: 81.8182% (minimum 99%, Missing); pituitary gland: 90.0000% (minimum 99%, Missing); retina: 60.0000% (minimum 99%, Missing); spinal cord: 64.2857% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing)",0,80,unavailable,2.7,0,0.3,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000164796,CSMD3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.2,0.03,-0.74
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,16.9,12.4,12.9,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); thymus: 12.9 nTPM (manageable, limit 5); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 2); lymph node: 11.9 nTPM (protected, limit 2); colon: 11.6 nTPM (protected, limit 2); skin: 11.2 nTPM (manageable, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 2); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 2); kidney: 10 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 2); thyroid gland: 9.9 nTPM (manageable, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 4); adrenal gland: 9.5 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (manageable, limit 5); basal ganglia: 9.4 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 2); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 2); small intestine: 7.3 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164815,ORC5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.4311% (minimum 99%, Baseline (adaptation disabled)); amygdala: 74.0157% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.7347% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 59.6825% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.5135% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.6860% (minimum 99%, Baseline (adaptation disabled)); colon: 61.8421% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.6296% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.6048% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.5020% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 69.8885% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.6131% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.2778% (minimum 99%, Baseline (adaptation disabled)); liver: 52.6611% (minimum 99%, Baseline (adaptation disabled)); lung: 75.2000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.2378% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.0157% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.3171% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.7343% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.0307% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.2564% (minimum 97%, Baseline (adaptation disabled)); retina: 57.8462% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.6131% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.3636% (minimum 99%, Baseline (adaptation disabled)); skin: 62.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.0307% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.1638% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.5020% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.1159% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.2778% (minimum 97%, Baseline (adaptation disabled)); thymus: 59.3060% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.5052% (minimum 95%, Baseline (adaptation disabled)); tongue: 71.2121% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.9456% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,16.9,12.4,12.9,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); thymus: 12.9 nTPM (manageable, limit 5); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 2); lymph node: 11.9 nTPM (protected, limit 2); colon: 11.6 nTPM (protected, limit 2); skin: 11.2 nTPM (manageable, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 2); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 2); kidney: 10 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 2); thyroid gland: 9.9 nTPM (manageable, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 2); adrenal gland: 9.5 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (manageable, limit 5); basal ganglia: 9.4 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 2); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 2); small intestine: 7.3 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164815,ORC5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.35694,-0.367436,-0.463389
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 66.4311% (minimum 99%, Missing); amygdala: 74.0157% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 76.7347% (minimum 99%, Missing); cerebellum: 59.6825% (minimum 99%, Missing); cerebral cortex: 63.5135% (minimum 99%, Missing); choroid plexus: 77.6860% (minimum 99%, Missing); colon: 61.8421% (minimum 97%, Missing); duodenum: 69.6296% (minimum 99%, Missing); esophagus: 64.6048% (minimum 97%, Missing); heart muscle: 75.5020% (minimum 99%, Missing); hippocampal formation: 69.8885% (minimum 99%, Missing); hypothalamus: 68.6131% (minimum 99%, Missing); kidney: 65.2778% (minimum 99%, Missing); liver: 52.6611% (minimum 99%, Missing); lung: 75.2000% (minimum 99%, Missing); lymph node: 61.2378% (minimum 97%, Missing); midbrain: 74.0157% (minimum 99%, Missing); pancreas: 57.3171% (minimum 99%, Missing); parathyroid gland: 65.7343% (minimum 95%, Approved); pituitary gland: 72.0307% (minimum 99%, Missing); rectum: 60.2564% (minimum 97%, Missing); retina: 57.8462% (minimum 99%, Missing); salivary gland: 68.6131% (minimum 97%, Missing); skeletal muscle: 68.3636% (minimum 99%, Missing); skin: 62.6667% (minimum 95%, Missing); small intestine: 72.0307% (minimum 99%, Missing); smooth muscle: 64.1638% (minimum 99%, Missing); spinal cord: 75.5020% (minimum 99%, Missing); spleen: 68.1159% (minimum 95%, Missing); stomach: 65.2778% (minimum 97%, Missing); thymus: 59.3060% (minimum 95%, Missing); thyroid gland: 65.5052% (minimum 95%, Missing); tongue: 71.2121% (minimum 97%, Missing); urinary bladder: 63.9456% (minimum 97%, Missing)",0,0,routine_complete,16.9,12.4,12.9,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); thymus: 12.9 nTPM (manageable, limit 5); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 2); lymph node: 11.9 nTPM (protected, limit 2); colon: 11.6 nTPM (protected, limit 2); skin: 11.2 nTPM (manageable, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 2); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 2); kidney: 10 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 2); thyroid gland: 9.9 nTPM (manageable, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 4); adrenal gland: 9.5 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (manageable, limit 5); basal ganglia: 9.4 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 2); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 2); small intestine: 7.3 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164815,ORC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.35694,-0.367436,-0.463389
True,compatible,,True,True,False,,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,ENSG00000164871,SPAG11B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,ENSG00000164871,SPAG11B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.0299186,0.00983721
True,compatible,,True,True,True,,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,ENSG00000164871,SPAG11B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00983721
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,29,37.1,10.4,"tongue: 37.1 nTPM (protected, limit 2); skeletal muscle: 29 nTPM (vital, limit 2); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); salivary gland: 12.2 nTPM (protected, limit 2); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 2); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 2); thyroid gland: 10.4 nTPM (manageable, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 2); urinary bladder: 8.3 nTPM (protected, limit 2); thymus: 7.3 nTPM (manageable, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 2); esophagus: 5.4 nTPM (protected, limit 2); lymph node: 5.3 nTPM (protected, limit 2); lung: 5 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164898,FMC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.9487% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 50.4464% (minimum 99%, Baseline (adaptation disabled)); amygdala: 46.6942% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 44.8413% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.6977% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 63.4831% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.6726% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 32.0113% (minimum 99%, Baseline (adaptation disabled)); colon: 54.5894% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.7778% (minimum 99%, Baseline (adaptation disabled)); esophagus: 67.6647% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 29.0488% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 48.2906% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 47.4790% (minimum 99%, Baseline (adaptation disabled)); kidney: 41.6974% (minimum 99%, Baseline (adaptation disabled)); liver: 39.5105% (minimum 99%, Baseline (adaptation disabled)); lung: 69.3252% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.0723% (minimum 97%, Baseline (adaptation disabled)); midbrain: 46.3115% (minimum 99%, Baseline (adaptation disabled)); pancreas: 53.0516% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.3636% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 49.1304% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.7531% (minimum 97%, Baseline (adaptation disabled)); retina: 79.0210% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 48.0851% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 28.0397% (minimum 99%, Baseline (adaptation disabled)); skin: 70.1863% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.4309% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.8389% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.2045% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.6726% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.7527% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.0737% (minimum 95%, Baseline (adaptation disabled)); tongue: 23.3471% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.6531% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,29,37.1,10.4,"tongue: 37.1 nTPM (protected, limit 2); skeletal muscle: 29 nTPM (vital, limit 1); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); salivary gland: 12.2 nTPM (protected, limit 2); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 2); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 2); thyroid gland: 10.4 nTPM (manageable, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 2); urinary bladder: 8.3 nTPM (protected, limit 2); adipose tissue: 8.2 nTPM (manageable, limit 5); thymus: 7.3 nTPM (manageable, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); spleen: 6.3 nTPM (manageable, limit 5); bone marrow: 5.9 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 2); lymph node: 5.3 nTPM (protected, limit 2); lung: 5 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164898,FMC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.429263,-0.736529,-0.709603
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.9487% (minimum 90%, Approved); adrenal gland: 50.4464% (minimum 99%, Missing); amygdala: 46.6942% (minimum 99%, Missing); basal ganglia: 44.8413% (minimum 99%, Missing); bone marrow: 65.6977% (minimum 98%, Approved); cerebellum: 63.4831% (minimum 99%, Missing); cerebral cortex: 50.6726% (minimum 99%, Missing); choroid plexus: 32.0113% (minimum 99%, Missing); colon: 54.5894% (minimum 97%, Missing); duodenum: 62.7778% (minimum 99%, Missing); esophagus: 67.6647% (minimum 97%, Missing); heart muscle: 29.0488% (minimum 99%, Missing); hippocampal formation: 48.2906% (minimum 99%, Missing); hypothalamus: 47.4790% (minimum 99%, Missing); kidney: 41.6974% (minimum 99%, Missing); liver: 39.5105% (minimum 99%, Missing); lung: 69.3252% (minimum 99%, Missing); lymph node: 68.0723% (minimum 97%, Missing); midbrain: 46.3115% (minimum 99%, Missing); pancreas: 53.0516% (minimum 99%, Missing); parathyroid gland: 51.3636% (minimum 97%, Missing); pituitary gland: 49.1304% (minimum 99%, Missing); rectum: 69.7531% (minimum 97%, Missing); retina: 79.0210% (minimum 99%, Missing); salivary gland: 48.0851% (minimum 97%, Missing); skeletal muscle: 28.0397% (minimum 98%, Approved); skin: 70.1863% (minimum 95%, Missing); small intestine: 62.4309% (minimum 99%, Missing); smooth muscle: 75.8389% (minimum 98%, Approved); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 64.2045% (minimum 90%, Approved); stomach: 50.6726% (minimum 97%, Missing); thymus: 60.7527% (minimum 95%, Missing); thyroid gland: 52.0737% (minimum 95%, Missing); tongue: 23.3471% (minimum 97%, Missing); urinary bladder: 57.6531% (minimum 97%, Missing)",0,5,partial,29,37.1,10.4,"tongue: 37.1 nTPM (protected, limit 2); skeletal muscle: 29 nTPM (vital, limit 2); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); salivary gland: 12.2 nTPM (protected, limit 2); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 2); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 2); thyroid gland: 10.4 nTPM (manageable, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 2); urinary bladder: 8.3 nTPM (protected, limit 2); thymus: 7.3 nTPM (manageable, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 2); esophagus: 5.4 nTPM (protected, limit 2); lymph node: 5.3 nTPM (protected, limit 2); lung: 5 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 2); smooth muscle: 3.6 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164898,FMC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.429263,-0.736529,-0.699603
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,10.9,1,0,"skeletal muscle: 10.9 nTPM (vital, limit 2)",,51,not_established,not_triggered,,,ENSG00000164900,GBX1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.0392% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 92.5926% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 31.4465% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0392% (minimum 99%, Baseline (adaptation disabled)); tongue: 83.3333% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,10.9,1,0,"skeletal muscle: 10.9 nTPM (vital, limit 1)",,51,not_established,not_triggered,,,ENSG00000164900,GBX1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.05,-0.136667,-0.675535
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.0392% (minimum 99%, Missing); heart muscle: 92.5926% (minimum 98%, Approved); skeletal muscle: 31.4465% (minimum 98%, Approved); spinal cord: 98.0392% (minimum 99%, Missing); tongue: 83.3333% (minimum 97%, Missing)",0,4,partial,10.9,1,0,"skeletal muscle: 10.9 nTPM (vital, limit 2)",,51,not_established,not_triggered,,,ENSG00000164900,GBX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.05,-0.136667,-0.665535
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,27,14.3,19.5,"bone marrow: 27 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); parathyroid gland: 14.3 nTPM (protected, limit 2); lymph node: 14.1 nTPM (protected, limit 2); smooth muscle: 13.4 nTPM (vital, limit 2); thyroid gland: 12.9 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); liver: 12.1 nTPM (vital, limit 2); retina: 12 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 2); rectum: 11.3 nTPM (protected, limit 2); spleen: 11.1 nTPM (manageable, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 2); pancreas: 10 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 2); heart muscle: 9.6 nTPM (vital, limit 2); esophagus: 9.4 nTPM (protected, limit 2); skin: 9.4 nTPM (manageable, limit 5); salivary gland: 9.3 nTPM (protected, limit 4); tongue: 8.9 nTPM (protected, limit 2); small intestine: 8.8 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164944,VIRMA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.4192% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.1057% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.5556% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.5556% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.6364% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.1057% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.9231% (minimum 99%, Baseline (adaptation disabled)); colon: 63.9098% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.2731% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.3939% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.9098% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.2332% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.3410% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.8182% (minimum 99%, Baseline (adaptation disabled)); liver: 58.4192% (minimum 99%, Baseline (adaptation disabled)); lung: 62.0438% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.6624% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.2332% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.9630% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 54.3131% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.5931% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.0707% (minimum 97%, Baseline (adaptation disabled)); retina: 58.6207% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.6388% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 66.9291% (minimum 99%, Baseline (adaptation disabled)); skin: 64.3939% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.8915% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.9211% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.5931% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.4982% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.0707% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.5753% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.8562% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.6371% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.7306% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,27,14.3,19.5,"bone marrow: 27 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); parathyroid gland: 14.3 nTPM (protected, limit 2); lymph node: 14.1 nTPM (protected, limit 2); smooth muscle: 13.4 nTPM (vital, limit 1); thyroid gland: 12.9 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); liver: 12.1 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 2); rectum: 11.3 nTPM (protected, limit 2); spleen: 11.1 nTPM (manageable, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 2); pancreas: 10 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 2); heart muscle: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 2); skin: 9.4 nTPM (manageable, limit 5); salivary gland: 9.3 nTPM (protected, limit 2); tongue: 8.9 nTPM (protected, limit 2); small intestine: 8.8 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164944,VIRMA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.484247,-0.426869,-0.603636
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.4192% (minimum 95%, Missing); adrenal gland: 69.1057% (minimum 99%, Missing); amygdala: 75.5556% (minimum 99%, Missing); basal ganglia: 75.5556% (minimum 99%, Missing); bone marrow: 38.6364% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 69.1057% (minimum 99%, Missing); choroid plexus: 76.9231% (minimum 99%, Missing); colon: 63.9098% (minimum 97%, Missing); duodenum: 68.2731% (minimum 99%, Missing); esophagus: 64.3939% (minimum 97%, Missing); heart muscle: 63.9098% (minimum 98%, Approved); hippocampal formation: 76.2332% (minimum 99%, Missing); hypothalamus: 78.3410% (minimum 99%, Missing); kidney: 61.8182% (minimum 99%, Missing); liver: 58.4192% (minimum 98%, Approved); lung: 62.0438% (minimum 99%, Missing); lymph node: 54.6624% (minimum 97%, Missing); midbrain: 76.2332% (minimum 99%, Missing); pancreas: 62.9630% (minimum 99%, Missing); parathyroid gland: 54.3131% (minimum 97%, Missing); pituitary gland: 73.5931% (minimum 99%, Missing); rectum: 60.0707% (minimum 97%, Missing); retina: 58.6207% (minimum 99%, Missing); salivary gland: 64.6388% (minimum 95%, Approved); skeletal muscle: 66.9291% (minimum 99%, Missing); skin: 64.3939% (minimum 95%, Missing); small intestine: 65.8915% (minimum 99%, Missing); smooth muscle: 55.9211% (minimum 98%, Approved); spinal cord: 73.5931% (minimum 99%, Missing); spleen: 60.4982% (minimum 95%, Missing); stomach: 60.0707% (minimum 97%, Missing); thymus: 46.5753% (minimum 95%, Missing); thyroid gland: 56.8562% (minimum 95%, Missing); tongue: 65.6371% (minimum 97%, Missing); urinary bladder: 62.7306% (minimum 97%, Missing)",0,5,partial,27,14.3,19.5,"bone marrow: 27 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); parathyroid gland: 14.3 nTPM (protected, limit 2); lymph node: 14.1 nTPM (protected, limit 2); smooth muscle: 13.4 nTPM (vital, limit 2); thyroid gland: 12.9 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); liver: 12.1 nTPM (vital, limit 2); retina: 12 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 2); rectum: 11.3 nTPM (protected, limit 2); spleen: 11.1 nTPM (manageable, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 2); pancreas: 10 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 2); heart muscle: 9.6 nTPM (vital, limit 2); esophagus: 9.4 nTPM (protected, limit 2); skin: 9.4 nTPM (manageable, limit 5); salivary gland: 9.3 nTPM (protected, limit 4); tongue: 8.9 nTPM (protected, limit 2); small intestine: 8.8 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000164944,VIRMA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.484247,-0.426869,-0.603636
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.6,11.4,4.6,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 2); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); smooth muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); hypothalamus: 5.6 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); urinary bladder: 4.9 nTPM (protected, limit 2); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164975,SNAPC3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.2000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 55.6338% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.8345% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.6122% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.6464% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.7415% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 56.4286% (minimum 99%, Baseline (adaptation disabled)); colon: 58.5185% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.9492% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.3784% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 40.5128% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.4828% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.5185% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.7097% (minimum 99%, Baseline (adaptation disabled)); liver: 68.1034% (minimum 99%, Baseline (adaptation disabled)); lung: 65.2893% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.1712% (minimum 97%, Baseline (adaptation disabled)); midbrain: 56.8345% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.7692% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.6338% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.2403% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.2893% (minimum 97%, Baseline (adaptation disabled)); retina: 56.4286% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.2276% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 45.9302% (minimum 99%, Baseline (adaptation disabled)); skin: 66.9492% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.6984% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.0284% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.4286% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.3866% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.2000% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.3866% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.7541% (minimum 95%, Baseline (adaptation disabled)); tongue: 40.9326% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.7188% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.6,11.4,4.6,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 2); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); smooth muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); hypothalamus: 5.6 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); urinary bladder: 4.9 nTPM (protected, limit 2); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164975,SNAPC3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.318,-0.560674,-0.584872
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.2000% (minimum 95%, Missing); adrenal gland: 50.0000% (minimum 99%, Missing); amygdala: 55.6338% (minimum 99%, Missing); basal ganglia: 56.8345% (minimum 99%, Missing); bone marrow: 80.6122% (minimum 99%, Missing); cerebellum: 43.6464% (minimum 99%, Missing); cerebral cortex: 53.7415% (minimum 99%, Missing); choroid plexus: 56.4286% (minimum 99%, Missing); colon: 58.5185% (minimum 97%, Missing); duodenum: 66.9492% (minimum 99%, Missing); esophagus: 53.3784% (minimum 97%, Missing); heart muscle: 40.5128% (minimum 99%, Missing); hippocampal formation: 54.4828% (minimum 99%, Missing); hypothalamus: 58.5185% (minimum 99%, Missing); kidney: 63.7097% (minimum 99%, Missing); liver: 68.1034% (minimum 99%, Missing); lung: 65.2893% (minimum 99%, Missing); lymph node: 71.1712% (minimum 97%, Missing); midbrain: 56.8345% (minimum 99%, Missing); pancreas: 60.7692% (minimum 99%, Missing); parathyroid gland: 55.6338% (minimum 97%, Missing); pituitary gland: 61.2403% (minimum 99%, Missing); rectum: 65.2893% (minimum 97%, Missing); retina: 56.4286% (minimum 99%, Missing); salivary gland: 64.2276% (minimum 97%, Missing); skeletal muscle: 45.9302% (minimum 99%, Missing); skin: 66.9492% (minimum 95%, Missing); small intestine: 62.6984% (minimum 99%, Missing); smooth muscle: 56.0284% (minimum 99%, Missing); spinal cord: 56.4286% (minimum 99%, Missing); spleen: 66.3866% (minimum 95%, Missing); stomach: 63.2000% (minimum 97%, Missing); thymus: 66.3866% (minimum 95%, Missing); thyroid gland: 64.7541% (minimum 95%, Missing); tongue: 40.9326% (minimum 97%, Missing); urinary bladder: 61.7188% (minimum 97%, Missing)",0,80,unavailable,11.6,11.4,4.6,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 2); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); smooth muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); hypothalamus: 5.6 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); urinary bladder: 4.9 nTPM (protected, limit 2); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000164975,SNAPC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.318,-0.560674,-0.584872
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,5.2,1.4,4.7,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000164989,CCDC171,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.1624% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.5966% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.3729% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.6179% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.4961% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.9549% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.8268% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.5966% (minimum 99%, Baseline (adaptation disabled)); colon: 92.3729% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.9655% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.3729% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.5966% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.5966% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.5966% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.8333% (minimum 99%, Baseline (adaptation disabled)); liver: 96.4602% (minimum 99%, Baseline (adaptation disabled)); lung: 91.5966% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.5966% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.3729% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.0826% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.6179% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.5966% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.5966% (minimum 97%, Baseline (adaptation disabled)); retina: 67.7019% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.9655% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.1624% (minimum 99%, Baseline (adaptation disabled)); skin: 83.2061% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.3729% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 77.3050% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.3443% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.7826% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.3443% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.8718% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.1562% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.5966% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 93.9655% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,5.2,1.4,4.7,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000164989,CCDC171,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.251282,-0.0838211,-0.312981
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.1624% (minimum 95%, Uncertain); adrenal gland: 91.5966% (minimum 99%, Missing); amygdala: 92.3729% (minimum 99%, Missing); basal ganglia: 88.6179% (minimum 99%, Missing); bone marrow: 84.4961% (minimum 99%, Missing); cerebellum: 81.9549% (minimum 99%, Missing); cerebral cortex: 85.8268% (minimum 99%, Missing); choroid plexus: 91.5966% (minimum 99%, Missing); colon: 92.3729% (minimum 97%, Missing); duodenum: 93.9655% (minimum 99%, Missing); esophagus: 92.3729% (minimum 97%, Missing); heart muscle: 91.5966% (minimum 99%, Missing); hippocampal formation: 91.5966% (minimum 99%, Missing); hypothalamus: 91.5966% (minimum 99%, Missing); kidney: 90.8333% (minimum 99%, Missing); liver: 96.4602% (minimum 99%, Missing); lung: 91.5966% (minimum 99%, Missing); lymph node: 91.5966% (minimum 97%, Uncertain); midbrain: 92.3729% (minimum 99%, Missing); pancreas: 90.0826% (minimum 99%, Missing); parathyroid gland: 88.6179% (minimum 97%, Missing); pituitary gland: 91.5966% (minimum 99%, Missing); rectum: 91.5966% (minimum 97%, Missing); retina: 67.7019% (minimum 99%, Missing); salivary gland: 93.9655% (minimum 97%, Missing); skeletal muscle: 93.1624% (minimum 99%, Missing); skin: 83.2061% (minimum 95%, Missing); small intestine: 92.3729% (minimum 99%, Missing); smooth muscle: 77.3050% (minimum 99%, Missing); spinal cord: 89.3443% (minimum 99%, Missing); spleen: 94.7826% (minimum 95%, Missing); stomach: 89.3443% (minimum 97%, Missing); thymus: 69.8718% (minimum 95%, Missing); thyroid gland: 85.1562% (minimum 95%, Missing); tongue: 91.5966% (minimum 97%, Missing); urinary bladder: 93.9655% (minimum 97%, Missing)",0,0,routine_complete,5.2,1.4,4.7,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000164989,CCDC171,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.251282,-0.0838211,-0.312981
True,compatible,,True,True,False,,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000165059,PRKACG,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000165059,PRKACG,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000165059,PRKACG,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0.1,0,0.4,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,ENSG00000165076,PRSS37,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.1,0,0.4,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,ENSG00000165076,PRSS37,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0401235,0.03,0.00751244
True,compatible,,True,True,True,,0,2,partial,0.1,0,0.4,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,ENSG00000165076,PRSS37,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0401235,0.03,0.00751244
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,14,partial,48.5,25.5,9.6,"skeletal muscle: 48.5 nTPM (vital, limit 6); tongue: 25.5 nTPM (protected, limit 2); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 6); midbrain: 14.4 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 2); hippocampal formation: 10.6 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); liver: 9.2 nTPM (vital, limit 6); thymus: 8.9 nTPM (manageable, limit 5); pancreas: 8.3 nTPM (vital, limit 6); kidney: 7.2 nTPM (vital, limit 6); adrenal gland: 6.3 nTPM (vital, limit 6); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165113,GKAP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.8641% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.1006% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.9268% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0353% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.2758% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.9268% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.0210% (minimum 99%, Baseline (adaptation disabled)); colon: 94.3286% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.7398% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 93.1100% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.8343% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.2439% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.4321% (minimum 99%, Baseline (adaptation disabled)); liver: 95.4858% (minimum 99%, Baseline (adaptation disabled)); lung: 97.9366% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.1100% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.9093% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.1124% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.1006% (minimum 99%, Baseline (adaptation disabled)); retina: 89.8016% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 80.0494% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.3974% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.0090% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.6928% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.3366% (minimum 97%, Baseline (adaptation disabled)); tongue: 88.4144% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.2413% (minimum 97%, Baseline (adaptation disabled))",0,14,partial,48.5,25.5,9.6,"skeletal muscle: 48.5 nTPM (vital, limit 1); tongue: 25.5 nTPM (protected, limit 2); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 2); hippocampal formation: 10.6 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 2); thyroid gland: 9.6 nTPM (manageable, limit 5); liver: 9.2 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); pancreas: 8.3 nTPM (vital, limit 1); adipose tissue: 7.7 nTPM (manageable, limit 5); urinary bladder: 7.6 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); kidney: 7.2 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 2); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165113,GKAP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00298727,-0.0858564,-0.189506
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 94.1006% (minimum 99%, Missing); basal ganglia: 94.9268% (minimum 99%, Missing); cerebellum: 91.2758% (minimum 99%, Missing); cerebral cortex: 94.9268% (minimum 95%, Enhanced); choroid plexus: 93.0210% (minimum 99%, Missing); colon: 94.3286% (minimum 97%, Missing); duodenum: 97.7398% (minimum 99%, Missing); heart muscle: 93.1100% (minimum 95%, Enhanced); hippocampal formation: 94.8343% (minimum 99%, Missing); hypothalamus: 93.2439% (minimum 99%, Missing); midbrain: 93.1100% (minimum 99%, Missing); pituitary gland: 94.1006% (minimum 99%, Missing); retina: 89.8016% (minimum 99%, Missing); skeletal muscle: 80.0494% (minimum 95%, Enhanced); small intestine: 97.3974% (minimum 99%, Missing); spinal cord: 93.6928% (minimum 99%, Missing); tongue: 88.4144% (minimum 97%, Missing)",0,14,partial,48.5,25.5,9.6,"skeletal muscle: 48.5 nTPM (vital, limit 6); tongue: 25.5 nTPM (protected, limit 2); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 6); midbrain: 14.4 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 2); hippocampal formation: 10.6 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); liver: 9.2 nTPM (vital, limit 6); thymus: 8.9 nTPM (manageable, limit 5); pancreas: 8.3 nTPM (vital, limit 6); kidney: 7.2 nTPM (vital, limit 6); adrenal gland: 6.3 nTPM (vital, limit 6); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165113,GKAP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00626536,-0.0858564,-0.149506
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000165120,SSMEM1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000165120,SSMEM1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.0068254
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000165120,SSMEM1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.0068254
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,0.2,1.1,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,ENSG00000165131,LLCFC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.5684% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0153% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.6,0.2,1.1,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,ENSG00000165131,LLCFC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0331547,0.0268944,-0.0143161
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.5684% (minimum 99%, Missing); spinal cord: 98.0153% (minimum 99%, Missing)",0,80,unavailable,1.6,0.2,1.1,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,ENSG00000165131,LLCFC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0331547,0.0268944,-0.0143161
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.7,1.1,0.3,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,ENSG00000165181,SHOC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.2000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.1567% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.6383% (minimum 99%, Baseline (adaptation disabled)); retina: 97.7064% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.0893% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.7,1.1,0.3,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,ENSG00000165181,SHOC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0361111,-0.0191071,-0.138
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.2000% (minimum 99%, Missing); bone marrow: 98.1567% (minimum 99%, Missing); kidney: 90.6383% (minimum 99%, Missing); retina: 97.7064% (minimum 99%, Missing); stomach: 95.0893% (minimum 97%, Missing)",0,80,unavailable,3.7,1.1,0.3,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,ENSG00000165181,SHOC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0361111,-0.0191071,-0.138
True,compatible,,True,True,False,,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,ENSG00000165182,CXorf58,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.4359% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.4359% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.4359% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.4359% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.4359% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.4359% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.4359% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 97.4359% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.4359% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.4359% (minimum 99%, Baseline (adaptation disabled)); retina: 90.4762% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 92.6829% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.4359% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4359% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 92.6829% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,ENSG00000165182,CXorf58,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0231707,-0.02,-0.0852381
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.4359% (minimum 99%, Missing); amygdala: 97.4359% (minimum 99%, Missing); basal ganglia: 97.4359% (minimum 99%, Missing); choroid plexus: 97.4359% (minimum 99%, Missing); heart muscle: 97.4359% (minimum 99%, Missing); hippocampal formation: 97.4359% (minimum 99%, Missing); hypothalamus: 97.4359% (minimum 99%, Missing); kidney: 95.0000% (minimum 99%, Missing); liver: 97.4359% (minimum 99%, Missing); midbrain: 97.4359% (minimum 99%, Missing); pancreas: 95.0000% (minimum 99%, Missing); parathyroid gland: 95.0000% (minimum 97%, Missing); pituitary gland: 97.4359% (minimum 99%, Missing); retina: 90.4762% (minimum 99%, Missing); skeletal muscle: 92.6829% (minimum 99%, Missing); small intestine: 97.4359% (minimum 99%, Missing); spinal cord: 97.4359% (minimum 99%, Missing); thyroid gland: 92.6829% (minimum 95%, Missing)",0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,ENSG00000165182,CXorf58,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0231707,-0.02,-0.0852381
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.2,6.6,0.4,"kidney: 11.2 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); stomach: 3.3 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,ENSG00000165188,RNF183,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.1366% (minimum 99%, Baseline (adaptation disabled)); colon: 96.9325% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.5309% (minimum 99%, Baseline (adaptation disabled)); esophagus: 76.6990% (minimum 97%, Baseline (adaptation disabled)); kidney: 58.5185% (minimum 99%, Baseline (adaptation disabled)); liver: 98.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1366% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1366% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 89.2655% (minimum 99%, Baseline (adaptation disabled)); retina: 92.9412% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.5357% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.1366% (minimum 99%, Baseline (adaptation disabled)); stomach: 82.7225% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.2,6.6,0.4,"kidney: 11.2 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); stomach: 3.3 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,ENSG00000165188,RNF183,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0253086,-0.264643,-0.404815
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.1366% (minimum 99%, Missing); colon: 96.9325% (minimum 97%, Missing); duodenum: 97.5309% (minimum 99%, Missing); esophagus: 76.6990% (minimum 97%, Missing); kidney: 58.5185% (minimum 99%, Missing); liver: 98.7500% (minimum 99%, Missing); lung: 98.1366% (minimum 99%, Missing); pancreas: 98.1366% (minimum 99%, Missing); pituitary gland: 89.2655% (minimum 99%, Missing); retina: 92.9412% (minimum 99%, Missing); salivary gland: 70.5357% (minimum 97%, Missing); small intestine: 98.1366% (minimum 99%, Missing); stomach: 82.7225% (minimum 97%, Missing)",0,80,unavailable,11.2,6.6,0.4,"kidney: 11.2 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); stomach: 3.3 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,ENSG00000165188,RNF183,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0253086,-0.264643,-0.404815
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000165204,OR1K1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000165204,OR1K1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000165204,OR1K1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,25.8,4.4,8.4,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 2); rectum: 3.2 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000165244,ZNF367,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.8219% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.7692% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.7647% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 18.6120% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.0986% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.0986% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.1613% (minimum 99%, Baseline (adaptation disabled)); colon: 67.0455% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.8161% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.9512% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.6835% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.2857% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.5072% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.0455% (minimum 99%, Baseline (adaptation disabled)); liver: 35.9756% (minimum 99%, Baseline (adaptation disabled)); lung: 84.2857% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.2816% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.8219% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.9444% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.7297% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.1613% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.8352% (minimum 97%, Baseline (adaptation disabled)); retina: 83.0986% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.3939% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.8219% (minimum 99%, Baseline (adaptation disabled)); skin: 63.4409% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.0455% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.9512% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.6410% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.9444% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.7500% (minimum 97%, Baseline (adaptation disabled)); thymus: 41.2587% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.2857% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.4118% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.8219% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,25.8,4.4,8.4,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 2); rectum: 3.2 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000165244,ZNF367,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.537413,-0.397184,-0.80388
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.8219% (minimum 95%, Uncertain); adrenal gland: 90.7692% (minimum 99%, Missing); amygdala: 86.7647% (minimum 99%, Missing); basal ganglia: 78.6667% (minimum 99%, Missing); bone marrow: 18.6120% (minimum 99%, Missing); cerebellum: 83.0986% (minimum 99%, Missing); cerebral cortex: 83.0986% (minimum 99%, Missing); choroid plexus: 95.1613% (minimum 99%, Missing); colon: 67.0455% (minimum 97%, Missing); duodenum: 67.8161% (minimum 99%, Missing); esophagus: 71.9512% (minimum 97%, Missing); heart muscle: 74.6835% (minimum 99%, Missing); hippocampal formation: 84.2857% (minimum 99%, Missing); hypothalamus: 85.5072% (minimum 99%, Missing); kidney: 67.0455% (minimum 99%, Missing); liver: 35.9756% (minimum 99%, Missing); lung: 84.2857% (minimum 99%, Uncertain); lymph node: 57.2816% (minimum 97%, Uncertain); midbrain: 80.8219% (minimum 99%, Missing); pancreas: 81.9444% (minimum 99%, Uncertain); parathyroid gland: 79.7297% (minimum 97%, Missing); pituitary gland: 95.1613% (minimum 99%, Missing); rectum: 64.8352% (minimum 97%, Uncertain); retina: 83.0986% (minimum 99%, Missing); salivary gland: 89.3939% (minimum 97%, Uncertain); skeletal muscle: 80.8219% (minimum 99%, Missing); skin: 63.4409% (minimum 95%, Missing); small intestine: 67.0455% (minimum 99%, Missing); smooth muscle: 71.9512% (minimum 99%, Uncertain); spinal cord: 75.6410% (minimum 99%, Missing); spleen: 81.9444% (minimum 95%, Missing); stomach: 73.7500% (minimum 97%, Missing); thymus: 41.2587% (minimum 95%, Missing); thyroid gland: 84.2857% (minimum 95%, Missing); tongue: 69.4118% (minimum 97%, Missing); urinary bladder: 80.8219% (minimum 97%, Missing)",0,3,partial,25.8,4.4,8.4,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 2); rectum: 3.2 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); tongue: 2.6 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000165244,ZNF367,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.537413,-0.397184,-0.80388
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,50.1,0.1,0.3,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000165309,ARMC3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.7778% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.0940% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.8532% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 46.2446% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.0886% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.5074% (minimum 99%, Baseline (adaptation disabled)); lung: 92.6882% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.2912% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.0721% (minimum 99%, Baseline (adaptation disabled)); retina: 98.8532% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.9545% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,50.1,0.1,0.3,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000165309,ARMC3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0430876,0.0276852,-0.527554
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.7778% (minimum 99%, Missing); basal ganglia: 92.0940% (minimum 99%, Missing); choroid plexus: 46.2446% (minimum 99%, Missing); hippocampal formation: 93.0886% (minimum 99%, Missing); hypothalamus: 91.5074% (minimum 99%, Missing); lung: 92.6882% (minimum 95%, Enhanced); midbrain: 97.2912% (minimum 99%, Missing); pituitary gland: 97.0721% (minimum 99%, Missing); retina: 98.8532% (minimum 99%, Missing); spinal cord: 97.9545% (minimum 99%, Missing)",0,4,partial,50.1,0.1,0.3,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000165309,ARMC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0476852,0.0276852,-0.527554
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.4,0.3,0.9,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000165325,DEUP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9512% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.1481% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.4419% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.7578% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.2096% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.1481% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1481% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.7578% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.2096% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.9075% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.2096% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 94.6429% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.4,0.3,0.9,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000165325,DEUP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,-0.00357143,0.0114815,-0.0709249
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9512% (minimum 99%, Missing); basal ganglia: 98.1481% (minimum 99%, Missing); choroid plexus: 92.4419% (minimum 99%, Missing); hippocampal formation: 98.7578% (minimum 99%, Missing); hypothalamus: 95.2096% (minimum 99%, Missing); kidney: 98.1481% (minimum 99%, Missing); lung: 98.1481% (minimum 99%, Missing); midbrain: 98.7578% (minimum 99%, Missing); pancreas: 95.2096% (minimum 99%, Missing); pituitary gland: 91.9075% (minimum 99%, Missing); spinal cord: 95.2096% (minimum 99%, Missing); thyroid gland: 94.6429% (minimum 95%, Missing)",0,80,unavailable,1.4,0.3,0.9,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000165325,DEUP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,-0.00357143,0.0114815,-0.0709249
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,23.9,0.6,0.7,"choroid plexus: 23.9 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000165383,LRRC18,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.5075% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.3504% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 35.5795% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.5075% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.7778% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.7778% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.7778% (minimum 99%, Baseline (adaptation disabled)); lung: 91.0345% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.6522% (minimum 97%, Baseline (adaptation disabled)); skin: 94.9640% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.7778% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,23.9,0.6,0.7,"choroid plexus: 23.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000165383,LRRC18,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,-0.000359712,-0.0134783,-0.634205
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.5075% (minimum 99%, Missing); choroid plexus: 35.5795% (minimum 99%, Missing); hippocampal formation: 97.7778% (minimum 99%, Missing); hypothalamus: 97.7778% (minimum 99%, Missing); lung: 91.0345% (minimum 95%, Enhanced)",0,4,partial,23.9,0.6,0.7,"choroid plexus: 23.9 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000165383,LRRC18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.05,0.03,-0.634205
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,4.7,4.2,11.8,"thymus: 11.8 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 2); lymph node: 4.2 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165480,SKA3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.3871% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.3871% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.3871% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 56.4815% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.3871% (minimum 99%, Baseline (adaptation disabled)); colon: 78.2051% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.9155% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.2152% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 96.8254% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.3871% (minimum 99%, Baseline (adaptation disabled)); liver: 96.8254% (minimum 99%, Baseline (adaptation disabled)); lung: 96.8254% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.2233% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.3871% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.7778% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.8254% (minimum 97%, Baseline (adaptation disabled)); skin: 78.2051% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.3086% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.7222% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.7059% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.9155% (minimum 97%, Baseline (adaptation disabled)); thymus: 34.0782% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.8462% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,4.7,4.2,11.8,"thymus: 11.8 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 2); rectum: 2.9 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165480,SKA3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.609218,-0.377767,-0.425185
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.3871% (minimum 99%, Missing); basal ganglia: 98.3871% (minimum 99%, Missing); bone marrow: 56.4815% (minimum 98%, Approved); colon: 78.2051% (minimum 95%, Approved); duodenum: 85.9155% (minimum 98%, Approved); esophagus: 77.2152% (minimum 95%, Approved); hippocampal formation: 96.8254% (minimum 99%, Missing); liver: 96.8254% (minimum 98%, Approved); lung: 96.8254% (minimum 98%, Approved); lymph node: 59.2233% (minimum 95%, Approved); midbrain: 98.3871% (minimum 99%, Missing); rectum: 67.7778% (minimum 95%, Approved); skin: 78.2051% (minimum 90%, Approved); small intestine: 75.3086% (minimum 98%, Approved); smooth muscle: 84.7222% (minimum 98%, Approved); spleen: 89.7059% (minimum 90%, Approved); stomach: 85.9155% (minimum 95%, Approved); thymus: 34.0782% (minimum 95%, Missing); urinary bladder: 93.8462% (minimum 95%, Approved)",0,3,partial,4.7,4.2,11.8,"thymus: 11.8 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 2); lymph node: 4.2 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165480,SKA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.609218,-0.357767,-0.415185
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,7.7,4.3,5.2,"bone marrow: 7.7 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000165490,DDIAS,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.1739% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.3636% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.1481% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 57.9235% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1481% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.3636% (minimum 99%, Baseline (adaptation disabled)); colon: 85.4839% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.6033% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.1045% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.4955% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.1481% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.3636% (minimum 99%, Baseline (adaptation disabled)); liver: 90.5983% (minimum 99%, Baseline (adaptation disabled)); lung: 76.2590% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.1409% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.1481% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.1739% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.4646% (minimum 97%, Baseline (adaptation disabled)); retina: 94.6429% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.9825% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.1739% (minimum 99%, Baseline (adaptation disabled)); skin: 82.8125% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.6033% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.4839% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.1481% (minimum 99%, Baseline (adaptation disabled)); spleen: 79.1045% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.1739% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.0886% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.1739% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.2590% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,7.7,4.3,5.2,"bone marrow: 7.7 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000165490,DDIAS,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.279114,-0.258591,-0.410765
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.1739% (minimum 95%, Missing); adrenal gland: 96.3636% (minimum 98%, Approved); amygdala: 98.1481% (minimum 99%, Missing); bone marrow: 57.9235% (minimum 99%, Missing); cerebral cortex: 96.3636% (minimum 98%, Approved); colon: 85.4839% (minimum 97%, Missing); duodenum: 87.6033% (minimum 99%, Missing); esophagus: 79.1045% (minimum 97%, Missing); heart muscle: 95.4955% (minimum 98%, Approved); hippocampal formation: 98.1481% (minimum 99%, Missing); kidney: 96.3636% (minimum 98%, Approved); liver: 90.5983% (minimum 98%, Approved); lung: 76.2590% (minimum 99%, Missing); lymph node: 71.1409% (minimum 97%, Missing); midbrain: 98.1481% (minimum 99%, Missing); pancreas: 92.1739% (minimum 98%, Approved); rectum: 83.4646% (minimum 97%, Missing); retina: 94.6429% (minimum 99%, Missing); salivary gland: 92.9825% (minimum 95%, Approved); skeletal muscle: 92.1739% (minimum 98%, Approved); skin: 82.8125% (minimum 95%, Missing); small intestine: 87.6033% (minimum 99%, Missing); smooth muscle: 85.4839% (minimum 99%, Missing); spinal cord: 98.1481% (minimum 99%, Missing); spleen: 79.1045% (minimum 95%, Missing); stomach: 92.1739% (minimum 97%, Missing); thymus: 67.0886% (minimum 95%, Missing); tongue: 92.1739% (minimum 97%, Missing); urinary bladder: 76.2590% (minimum 97%, Missing)",0,6,partial,7.7,4.3,5.2,"bone marrow: 7.7 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); esophagus: 2.8 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000165490,DDIAS,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.279114,-0.258591,-0.410765
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.6,2.6,0,"rectum: 2.6 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000165496,RPL10L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,0.6,2.6,0,"rectum: 2.6 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000165496,RPL10L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.00173913,0.00333333
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,0.6,2.6,0,"rectum: 2.6 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000165496,RPL10L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.00173913,0.00333333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,4.2,0.5,0.6,"retina: 4.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165555,NOXRED1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.3662% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.3662% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.1014% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.5294% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.1014% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.5294% (minimum 99%, Baseline (adaptation disabled)); colon: 95.7143% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.7143% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5294% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.7143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.0556% (minimum 99%, Baseline (adaptation disabled)); liver: 95.7143% (minimum 99%, Baseline (adaptation disabled)); lung: 97.1014% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.0556% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.1014% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.3662% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.7143% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.5405% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.7143% (minimum 97%, Baseline (adaptation disabled)); retina: 61.4679% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.1014% (minimum 99%, Baseline (adaptation disabled)); skin: 91.7808% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.1014% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1014% (minimum 99%, Baseline (adaptation disabled)); thymus: 94.3662% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.7808% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,4.2,0.5,0.6,"retina: 4.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165555,NOXRED1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0321918,-0.0394444,-0.375321
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.3662% (minimum 98%, Approved); amygdala: 95.7143% (minimum 99%, Missing); basal ganglia: 94.3662% (minimum 99%, Missing); bone marrow: 97.1014% (minimum 98%, Approved); cerebral cortex: 97.1014% (minimum 98%, Approved); choroid plexus: 98.5294% (minimum 99%, Missing); duodenum: 95.7143% (minimum 98%, Approved); hippocampal formation: 95.7143% (minimum 99%, Missing); hypothalamus: 95.7143% (minimum 99%, Missing); kidney: 93.0556% (minimum 98%, Approved); liver: 95.7143% (minimum 98%, Approved); lung: 97.1014% (minimum 98%, Approved); lymph node: 93.0556% (minimum 95%, Approved); midbrain: 97.1014% (minimum 99%, Missing); pancreas: 94.3662% (minimum 98%, Approved); pituitary gland: 90.5405% (minimum 99%, Missing); retina: 61.4679% (minimum 99%, Missing); skeletal muscle: 97.1014% (minimum 98%, Approved); small intestine: 95.7143% (minimum 98%, Approved); smooth muscle: 97.1014% (minimum 98%, Approved); spinal cord: 97.1014% (minimum 99%, Missing); thymus: 94.3662% (minimum 95%, Missing)",0,3,partial,4.2,0.5,0.6,"retina: 4.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165555,NOXRED1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00633803,-0.0194444,-0.375321
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,3.3,1.5,3.2,"retina: 3.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; thymus; tonsil,ENSG00000165568,AKR1E2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.1961% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.8333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.3351% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.3351% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.1961% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.8421% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.8333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.8421% (minimum 99%, Baseline (adaptation disabled)); colon: 93.8776% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.8776% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.4010% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.0891% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.3351% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.8421% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.3368% (minimum 99%, Baseline (adaptation disabled)); liver: 97.3545% (minimum 99%, Baseline (adaptation disabled)); lung: 90.6404% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.3351% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.8421% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.7561% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.8454% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.3545% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.3590% (minimum 97%, Baseline (adaptation disabled)); retina: 84.7926% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.8454% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.9293% (minimum 99%, Baseline (adaptation disabled)); skin: 94.3590% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.8454% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.1961% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.8723% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.8776% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.4623% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 85.1852% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.8333% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.3590% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,3.3,1.5,3.2,"retina: 3.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; thymus; tonsil,ENSG00000165568,AKR1E2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0981481,-0.0453769,-0.142074
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.8333% (minimum 99%, Missing); amygdala: 96.3351% (minimum 99%, Missing); basal ganglia: 96.3351% (minimum 99%, Missing); bone marrow: 90.1961% (minimum 95%, Enhanced); cerebral cortex: 95.8333% (minimum 99%, Missing); choroid plexus: 96.8421% (minimum 99%, Missing); colon: 93.8776% (minimum 97%, Missing); duodenum: 93.8776% (minimum 99%, Missing); heart muscle: 91.0891% (minimum 95%, Enhanced); hippocampal formation: 96.3351% (minimum 99%, Missing); hypothalamus: 96.8421% (minimum 99%, Missing); kidney: 95.3368% (minimum 99%, Missing); lung: 90.6404% (minimum 95%, Enhanced); midbrain: 96.8421% (minimum 99%, Missing); pancreas: 89.7561% (minimum 95%, Enhanced); pituitary gland: 97.3545% (minimum 99%, Missing); rectum: 94.3590% (minimum 97%, Missing); retina: 84.7926% (minimum 99%, Missing); salivary gland: 94.8454% (minimum 97%, Missing); skeletal muscle: 92.9293% (minimum 95%, Enhanced); skin: 94.3590% (minimum 95%, Missing); small intestine: 94.8454% (minimum 99%, Missing); smooth muscle: 90.1961% (minimum 95%, Enhanced); spinal cord: 97.8723% (minimum 99%, Missing); stomach: 92.4623% (minimum 97%, Missing); thyroid gland: 85.1852% (minimum 95%, Missing); tongue: 95.8333% (minimum 97%, Missing)",0,2,partial,3.3,1.5,3.2,"retina: 3.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; thymus; tonsil,ENSG00000165568,AKR1E2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0981481,-0.0453769,-0.142074
True,compatible,,True,True,False,,0,3,partial,0.2,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000165583,SSX5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 66.6667% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.0000% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,0.2,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000165583,SSX5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,-0.283333,-0.17,-0.323333
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 66.6667% (minimum 97%, Supported); heart muscle: 66.6667% (minimum 97%, Supported); parathyroid gland: 80.0000% (minimum 90%, Supported); spleen: 66.6667% (minimum 80%, Supported); tongue: 80.0000% (minimum 97%, Missing)",0,3,partial,0.2,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000165583,SSX5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,-0.133333,-0.17,-0.303333
True,compatible,,True,True,False,,0,3,partial,0.1,0,0.2,,,52,not_established,not_triggered,,,ENSG00000165584,SSX3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0.1,0,0.2,,,52,not_established,not_triggered,,,ENSG00000165584,SSX3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0349624,0.03,0.00242424
True,compatible,,True,True,True,,0,3,partial,0.1,0,0.2,,,52,not_established,not_triggered,,,ENSG00000165584,SSX3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,41.6,0.1,0.5,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000165643,SOHLH1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.8635% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.6355% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 28.2759% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.9064% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 46.5909% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.4167% (minimum 99%, Baseline (adaptation disabled)); midbrain: 85.8639% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 84.1026% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.1348% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,41.6,0.1,0.5,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000165643,SOHLH1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0204142,0.0239394,-0.707241
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.8635% (minimum 99%, Missing); basal ganglia: 76.6355% (minimum 99%, Missing); cerebellum: 82.0000% (minimum 99%, Missing); cerebral cortex: 28.2759% (minimum 99%, Missing); choroid plexus: 95.9064% (minimum 99%, Missing); hippocampal formation: 46.5909% (minimum 99%, Missing); hypothalamus: 85.4167% (minimum 99%, Missing); midbrain: 85.8639% (minimum 99%, Missing); pituitary gland: 84.1026% (minimum 99%, Missing); spinal cord: 92.1348% (minimum 99%, Missing)",0,80,unavailable,41.6,0.1,0.5,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000165643,SOHLH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0204142,0.0239394,-0.707241
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,9.9,3,4.6,"choroid plexus: 9.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165695,AK8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.4198% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.0570% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.9118% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0392% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.2836% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 71.6332% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.5251% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 94.6970% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.9368% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.9118% (minimum 99%, Baseline (adaptation disabled)); lung: 92.5926% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.1538% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.2763% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.2857% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.6330% (minimum 99%, Baseline (adaptation disabled)); retina: 90.5797% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.6330% (minimum 97%, Baseline (adaptation disabled)); skin: 93.9850% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 97.6562% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.8992% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.8992% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.3396% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.4595% (minimum 95%, Baseline (adaptation disabled))",0,7,partial,9.9,3,4.6,"choroid plexus: 9.9 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165695,AK8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.105405,-0.0771429,-0.273668
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.0570% (minimum 99%, Missing); basal ganglia: 91.9118% (minimum 99%, Missing); cerebral cortex: 93.2836% (minimum 95%, Enhanced); choroid plexus: 71.6332% (minimum 99%, Missing); hippocampal formation: 94.6970% (minimum 99%, Missing); hypothalamus: 92.9368% (minimum 99%, Missing); kidney: 91.9118% (minimum 99%, Missing); lung: 92.5926% (minimum 95%, Enhanced); midbrain: 96.1538% (minimum 99%, Missing); pituitary gland: 93.6330% (minimum 99%, Missing); retina: 90.5797% (minimum 99%, Missing); spinal cord: 96.8992% (minimum 99%, Missing); thymus: 94.3396% (minimum 95%, Missing)",0,7,partial,9.9,3,4.6,"choroid plexus: 9.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165695,AK8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00660377,0.0220635,-0.273668
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,18.9,11.1,15.2,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); cerebral cortex: 14.9 nTPM (vital, limit 6); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 6); pituitary gland: 11.2 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 6); cerebellum: 8.6 nTPM (vital, limit 6); retina: 7.9 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); adrenal gland: 7.4 nTPM (vital, limit 6); lung: 7.2 nTPM (vital, limit 6)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165698,SPACA9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.5185% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.7328% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.8183% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.8381% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.6858% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.5439% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.0990% (minimum 99%, Baseline (adaptation disabled)); colon: 91.9971% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.9915% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.2067% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.7326% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.9225% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.3973% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.4695% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2294% (minimum 99%, Baseline (adaptation disabled)); lung: 94.6588% (minimum 99%, Baseline (adaptation disabled)); midbrain: 88.9199% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.1567% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.9308% (minimum 99%, Baseline (adaptation disabled)); retina: 94.1697% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.0029% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.7616% (minimum 99%, Baseline (adaptation disabled)); skin: 91.7326% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.2561% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.4475% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.3657% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.2950% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.3089% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.3557% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.5805% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,18.9,11.1,15.2,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.9 nTPM (vital, limit 1); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 1); skin: 11.5 nTPM (manageable, limit 5); pituitary gland: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 2); heart muscle: 10 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); esophagus: 9.3 nTPM (protected, limit 2); cerebellum: 8.6 nTPM (vital, limit 1); retina: 7.9 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); adrenal gland: 7.4 nTPM (vital, limit 1); lung: 7.2 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 2); urinary bladder: 5.9 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); small intestine: 3.6 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165698,SPACA9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0564426,-0.0500288,-0.11901
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.5185% (minimum 95%, Enhanced); amygdala: 89.7328% (minimum 99%, Missing); basal ganglia: 87.8183% (minimum 99%, Missing); cerebellum: 93.6858% (minimum 95%, Enhanced); cerebral cortex: 89.5439% (minimum 95%, Enhanced); choroid plexus: 87.0990% (minimum 99%, Missing); heart muscle: 92.7326% (minimum 95%, Enhanced); hippocampal formation: 89.9225% (minimum 99%, Missing); hypothalamus: 87.3973% (minimum 99%, Missing); kidney: 91.4695% (minimum 95%, Enhanced); lung: 94.6588% (minimum 95%, Enhanced); midbrain: 88.9199% (minimum 99%, Missing); pituitary gland: 91.9308% (minimum 99%, Missing); retina: 94.1697% (minimum 99%, Missing); spinal cord: 88.3657% (minimum 99%, Missing); thymus: 94.3089% (minimum 95%, Missing)",0,6,partial,18.9,11.1,15.2,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); cerebral cortex: 14.9 nTPM (vital, limit 6); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 6); pituitary gland: 11.2 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 6); cerebellum: 8.6 nTPM (vital, limit 6); retina: 7.9 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); adrenal gland: 7.4 nTPM (vital, limit 6); lung: 7.2 nTPM (vital, limit 6)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165698,SPACA9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00691057,0.0168523,-0.11901
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000165805,C12orf50,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000165805,C12orf50,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000165805,C12orf50,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,13,partial,10.4,7,1.9,"pancreas: 10.4 nTPM (vital, limit 6); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); rectum: 5.4 nTPM (protected, limit 2); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165807,PPP1R36,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.9868% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.9011% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.3607% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2973% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.9011% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.2353% (minimum 99%, Baseline (adaptation disabled)); colon: 85.1064% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.9057% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.6301% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.0350% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2973% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 96.7742% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.5147% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.5862% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.2381% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.9565% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 90.6801% (minimum 97%, Baseline (adaptation disabled)); small intestine: 88.8889% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6301% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.3077% (minimum 99%, Baseline (adaptation disabled)); stomach: 83.7209% (minimum 97%, Baseline (adaptation disabled))",0,13,partial,10.4,7,1.9,"pancreas: 10.4 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); rectum: 5.4 nTPM (protected, limit 2); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 2); spinal cord: 3 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165807,PPP1R36,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.000131926,-0.132791,-0.214138
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.3607% (minimum 99%, Missing); basal ganglia: 97.2973% (minimum 99%, Missing); choroid plexus: 88.2353% (minimum 99%, Missing); colon: 85.1064% (minimum 97%, Missing); duodenum: 84.9057% (minimum 99%, Missing); hippocampal formation: 97.0350% (minimum 99%, Missing); hypothalamus: 97.2973% (minimum 99%, Missing); kidney: 93.7500% (minimum 95%, Enhanced); midbrain: 96.5147% (minimum 99%, Missing); pancreas: 77.5862% (minimum 95%, Enhanced); pituitary gland: 95.2381% (minimum 99%, Missing); rectum: 86.9565% (minimum 97%, Missing); small intestine: 88.8889% (minimum 99%, Missing); spinal cord: 92.3077% (minimum 99%, Missing)",0,13,partial,10.4,7,1.9,"pancreas: 10.4 nTPM (vital, limit 6); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 2); rectum: 5.4 nTPM (protected, limit 2); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165807,PPP1R36,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0444751,-0.118936,-0.174138
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,1103.8,72.1,1.3,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 2); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 2)",duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165828,PRAP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.7480% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.7480% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.5410% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.2000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.3471% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.4444% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 16.8079% (minimum 99%, Baseline (adaptation disabled)); colon: 14.1667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 1.1500% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.7480% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.7480% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.5410% (minimum 99%, Baseline (adaptation disabled)); kidney: 7.8444% (minimum 99%, Baseline (adaptation disabled)); liver: 1.7881% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5410% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8060% (minimum 97%, Baseline (adaptation disabled)); pancreas: 97.5410% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.7008% (minimum 99%, Baseline (adaptation disabled)); rectum: 25.6466% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 87.5000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.3471% (minimum 99%, Baseline (adaptation disabled)); skin: 90.1515% (minimum 95%, Baseline (adaptation disabled)); small intestine: 1.0666% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.1481% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.7008% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.9524% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,1103.8,72.1,1.3,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 2); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165828,PRAP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0484848,-0.828333,-0.979334
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.7480% (minimum 97%, Supported); amygdala: 96.7480% (minimum 99%, Missing); basal ganglia: 97.5410% (minimum 99%, Missing); bone marrow: 95.2000% (minimum 97%, Supported); cerebral cortex: 94.4444% (minimum 97%, Supported); choroid plexus: 16.8079% (minimum 99%, Missing); colon: 14.1667% (minimum 97%, Missing); duodenum: 1.1500% (minimum 99%, Missing); heart muscle: 96.7480% (minimum 97%, Supported); hippocampal formation: 97.5410% (minimum 99%, Missing); kidney: 7.8444% (minimum 99%, Missing); liver: 1.7881% (minimum 99%, Missing); lymph node: 88.8060% (minimum 90%, Supported); pituitary gland: 93.7008% (minimum 99%, Missing); rectum: 25.6466% (minimum 97%, Missing); salivary gland: 87.5000% (minimum 90%, Supported); small intestine: 1.0666% (minimum 99%, Missing); smooth muscle: 88.1481% (minimum 97%, Supported); stomach: 80.9524% (minimum 90%, Supported)",0,5,partial,1103.8,72.1,1.3,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 2); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 2)",duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165828,PRAP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0254098,-0.828333,-0.979334
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000165837,ERICH6B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 90.4762% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000165837,ERICH6B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.0852381
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 90.4762% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000165837,ERICH6B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.0852381
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,0.9,1.5,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000165863,SPMIP5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9738% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.9738% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6795% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6795% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.7981% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.7,0.9,1.5,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000165863,SPMIP5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0320789,0.0191697,-0.0102622
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9738% (minimum 99%, Missing); hypothalamus: 97.9738% (minimum 99%, Missing); kidney: 98.6795% (minimum 99%, Missing); pancreas: 98.6795% (minimum 99%, Missing); pituitary gland: 98.7981% (minimum 99%, Missing)",0,80,unavailable,1.7,0.9,1.5,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000165863,SPMIP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0320789,0.0191697,-0.0102622
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.9,1.5,8,"thymus: 8 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165891,E2F7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Baseline (adaptation disabled)); amygdala: 96.5517% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.5517% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 36.3636% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.5517% (minimum 99%, Baseline (adaptation disabled)); colon: 75.6757% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.5517% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.5517% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.5517% (minimum 99%, Baseline (adaptation disabled)); liver: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 90.3226% (minimum 99%, Baseline (adaptation disabled)); lymph node: 65.1163% (minimum 97%, Baseline (adaptation disabled)); pancreas: 96.5517% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.5517% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 93.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.3333% (minimum 97%, Baseline (adaptation disabled)); skin: 71.7949% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.7778% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.3226% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.3226% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.3529% (minimum 97%, Baseline (adaptation disabled)); thymus: 25.9259% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.5517% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.3529% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.9,1.5,8,"thymus: 8 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165891,E2F7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.690741,-0.318837,-0.626364
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Missing); amygdala: 96.5517% (minimum 99%, Missing); basal ganglia: 96.5517% (minimum 99%, Missing); bone marrow: 36.3636% (minimum 99%, Missing); cerebral cortex: 96.5517% (minimum 99%, Missing); colon: 75.6757% (minimum 97%, Missing); duodenum: 80.0000% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 93.3333% (minimum 99%, Missing); hippocampal formation: 96.5517% (minimum 99%, Missing); hypothalamus: 96.5517% (minimum 99%, Missing); kidney: 96.5517% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); lung: 90.3226% (minimum 99%, Missing); lymph node: 65.1163% (minimum 97%, Missing); pancreas: 96.5517% (minimum 99%, Missing); parathyroid gland: 96.5517% (minimum 97%, Missing); pituitary gland: 87.5000% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 93.3333% (minimum 99%, Missing); salivary gland: 93.3333% (minimum 97%, Missing); skin: 71.7949% (minimum 95%, Missing); small intestine: 77.7778% (minimum 99%, Missing); smooth muscle: 90.3226% (minimum 99%, Missing); spleen: 90.3226% (minimum 95%, Missing); stomach: 82.3529% (minimum 97%, Missing); thymus: 25.9259% (minimum 95%, Missing); tongue: 96.5517% (minimum 97%, Missing); urinary bladder: 82.3529% (minimum 97%, Missing)",0,80,unavailable,4.9,1.5,8,"thymus: 8 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000165891,E2F7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.690741,-0.318837,-0.626364
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,2.9,1.1,1.4,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000165923,AGBL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 90.2256% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.7742% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.3077% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.3607% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.3607% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 93.7500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.5610% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.7742% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.3607% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.7500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.7500% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.8889% (minimum 99%, Baseline (adaptation disabled)); liver: 80.5369% (minimum 99%, Baseline (adaptation disabled)); lung: 88.8889% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.3607% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.7500% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 88.2353% (minimum 99%, Baseline (adaptation disabled)); retina: 98.3607% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0000% (minimum 97%, Baseline (adaptation disabled)); small intestine: 90.9091% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.3607% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.7500% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.2381% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.4882% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.5522% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 91.6031% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,2.9,1.1,1.4,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000165923,AGBL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0544776,-0.0539695,-0.184631
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 90.2256% (minimum 99%, Missing); amygdala: 96.7742% (minimum 99%, Missing); basal ganglia: 92.3077% (minimum 99%, Missing); bone marrow: 98.3607% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 99%, Missing); cerebral cortex: 98.3607% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 93.7500% (minimum 97%, Missing); duodenum: 97.5610% (minimum 99%, Missing); esophagus: 96.7742% (minimum 97%, Missing); heart muscle: 98.3607% (minimum 99%, Missing); hippocampal formation: 93.7500% (minimum 99%, Missing); hypothalamus: 93.7500% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 80.5369% (minimum 99%, Missing); lung: 88.8889% (minimum 99%, Missing); lymph node: 96.0000% (minimum 97%, Missing); midbrain: 98.3607% (minimum 99%, Missing); pancreas: 93.7500% (minimum 99%, Missing); pituitary gland: 88.2353% (minimum 99%, Missing); retina: 98.3607% (minimum 99%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); small intestine: 90.9091% (minimum 99%, Missing); spinal cord: 98.3607% (minimum 99%, Missing); spleen: 93.7500% (minimum 95%, Missing); stomach: 95.2381% (minimum 97%, Missing); thymus: 94.4882% (minimum 95%, Missing); thyroid gland: 89.5522% (minimum 95%, Missing); urinary bladder: 91.6031% (minimum 97%, Missing)",0,7,partial,2.9,1.1,1.4,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000165923,AGBL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0544776,-0.0539695,-0.184631
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000165970,SLC6A5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"cerebellum: 30.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 25.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 33.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 27.2727% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000165970,SLC6A5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.74
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"cerebellum: 30.0000% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); lung: 25.0000% (minimum 99%, Missing); pituitary gland: 33.3333% (minimum 99%, Missing); spinal cord: 27.2727% (minimum 99%, Missing)",0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000165970,SLC6A5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.74
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.7,0.2,0.7,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000165972,CCDC38,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.4497% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.8824% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7879% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.1928% (minimum 99%, Baseline (adaptation disabled)); liver: 85.7895% (minimum 99%, Baseline (adaptation disabled)); retina: 97.0238% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.8824% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.7,0.2,0.7,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000165972,CCDC38,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.00882353,0.0178788,-0.132105
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.4497% (minimum 99%, Missing); bone marrow: 95.8824% (minimum 99%, Missing); cerebral cortex: 98.7879% (minimum 99%, Missing); kidney: 98.1928% (minimum 99%, Missing); liver: 85.7895% (minimum 99%, Missing); retina: 97.0238% (minimum 99%, Missing); skeletal muscle: 95.8824% (minimum 99%, Missing)",0,80,unavailable,2.7,0.2,0.7,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000165972,CCDC38,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.00882353,0.0178788,-0.132105
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,17.2,12.7,14.9,"bone marrow: 17.2 nTPM (vital, limit 6); spleen: 14.9 nTPM (manageable, limit 5); skin: 14.6 nTPM (manageable, limit 5); thymus: 13.3 nTPM (manageable, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 2); urinary bladder: 12 nTPM (protected, limit 2); small intestine: 12 nTPM (vital, limit 1); lymph node: 11.9 nTPM (protected, limit 2); colon: 11.7 nTPM (protected, limit 2); salivary gland: 11.5 nTPM (protected, limit 2); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); thyroid gland: 9.8 nTPM (manageable, limit 5); rectum: 9.8 nTPM (protected, limit 2); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 2); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166024,R3HCC1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 70.9602% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.4974% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.5613% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.2332% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.7895% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.3224% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.4711% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.4936% (minimum 99%, Baseline (adaptation disabled)); colon: 72.1429% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.0137% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.4651% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.1123% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.6712% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.7869% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.6619% (minimum 99%, Baseline (adaptation disabled)); liver: 69.6552% (minimum 99%, Baseline (adaptation disabled)); lung: 74.0831% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.8009% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.5851% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.9024% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 74.8148% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.2946% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.5611% (minimum 97%, Baseline (adaptation disabled)); retina: 75.7500% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.4880% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.1307% (minimum 99%, Baseline (adaptation disabled)); skin: 67.4833% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.6312% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.7869% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.0992% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.0354% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.7089% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.4954% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.5611% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.7368% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.6312% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,17.2,12.7,14.9,"bone marrow: 17.2 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); skin: 14.6 nTPM (manageable, limit 5); thymus: 13.3 nTPM (manageable, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 2); adipose tissue: 12.4 nTPM (manageable, limit 5); small intestine: 12 nTPM (vital, limit 1); urinary bladder: 12 nTPM (protected, limit 2); lymph node: 11.9 nTPM (protected, limit 2); colon: 11.7 nTPM (protected, limit 2); salivary gland: 11.5 nTPM (protected, limit 2); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); rectum: 9.8 nTPM (protected, limit 2); thyroid gland: 9.8 nTPM (manageable, limit 5); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 2); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166024,R3HCC1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.279646,-0.265349,-0.352105
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 78.4974% (minimum 99%, Missing); amygdala: 82.5613% (minimum 99%, Missing); basal ganglia: 81.2332% (minimum 99%, Missing); bone marrow: 63.7895% (minimum 95%, Enhanced); cerebellum: 76.3224% (minimum 99%, Missing); cerebral cortex: 83.4711% (minimum 99%, Missing); choroid plexus: 77.4936% (minimum 99%, Missing); colon: 72.1429% (minimum 97%, Missing); duodenum: 83.0137% (minimum 99%, Missing); esophagus: 70.4651% (minimum 97%, Missing); heart muscle: 79.1123% (minimum 99%, Missing); hippocampal formation: 81.6712% (minimum 99%, Missing); hypothalamus: 82.7869% (minimum 99%, Missing); kidney: 72.6619% (minimum 99%, Missing); liver: 69.6552% (minimum 99%, Missing); lung: 74.0831% (minimum 99%, Missing); lymph node: 71.8009% (minimum 97%, Missing); midbrain: 80.5851% (minimum 99%, Missing); pancreas: 73.9024% (minimum 99%, Missing); parathyroid gland: 74.8148% (minimum 97%, Missing); pituitary gland: 78.2946% (minimum 99%, Missing); rectum: 75.5611% (minimum 97%, Missing); retina: 75.7500% (minimum 99%, Missing); salivary gland: 72.4880% (minimum 97%, Missing); skeletal muscle: 76.1307% (minimum 99%, Missing); skin: 67.4833% (minimum 95%, Missing); small intestine: 71.6312% (minimum 99%, Missing); smooth muscle: 82.7869% (minimum 99%, Missing); spinal cord: 77.0992% (minimum 99%, Missing); spleen: 67.0354% (minimum 95%, Missing); stomach: 76.7089% (minimum 97%, Missing); thymus: 69.4954% (minimum 95%, Missing); thyroid gland: 75.5611% (minimum 95%, Missing); tongue: 79.7368% (minimum 97%, Missing); urinary bladder: 71.6312% (minimum 97%, Missing)",0,2,partial,17.2,12.7,14.9,"bone marrow: 17.2 nTPM (vital, limit 6); spleen: 14.9 nTPM (manageable, limit 5); skin: 14.6 nTPM (manageable, limit 5); thymus: 13.3 nTPM (manageable, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 2); urinary bladder: 12 nTPM (protected, limit 2); small intestine: 12 nTPM (vital, limit 1); lymph node: 11.9 nTPM (protected, limit 2); colon: 11.7 nTPM (protected, limit 2); salivary gland: 11.5 nTPM (protected, limit 2); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); thyroid gland: 9.8 nTPM (manageable, limit 5); rectum: 9.8 nTPM (protected, limit 2); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 2); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166024,R3HCC1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.279646,-0.265349,-0.312105
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000166049,PASD1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000166049,PASD1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000166049,PASD1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,20,12.7,30.2,"thyroid gland: 30.2 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 2); adipose tissue: 12.2 nTPM (manageable, limit 10); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 2); rectum: 10.6 nTPM (protected, limit 2); stomach: 10 nTPM (protected, limit 2); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 2); kidney: 8.8 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 2); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 4); parathyroid gland: 6.6 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); liver: 5.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000166068,SPRED1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5292% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.0841% (minimum 99%, Baseline (adaptation disabled)); amygdala: 48.3871% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 45.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.0704% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 71.0526% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 40.2985% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.8509% (minimum 99%, Baseline (adaptation disabled)); colon: 55.1020% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.7907% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.5876% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.5340% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 51.1364% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 57.9399% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.5381% (minimum 99%, Baseline (adaptation disabled)); liver: 71.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 44.4079% (minimum 99%, Baseline (adaptation disabled)); lymph node: 65.8537% (minimum 97%, Baseline (adaptation disabled)); midbrain: 54.2169% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.4190% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 67.1642% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.5862% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.0166% (minimum 97%, Baseline (adaptation disabled)); retina: 65.2174% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.4286% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.8509% (minimum 99%, Baseline (adaptation disabled)); skin: 69.2308% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.4714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.7849% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.5381% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.4468% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.8427% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 30.8924% (minimum 95%, Baseline (adaptation disabled)); tongue: 63.6792% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.5267% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,20,12.7,30.2,"thyroid gland: 30.2 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 2); adipose tissue: 12.2 nTPM (manageable, limit 5); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 2); rectum: 10.6 nTPM (protected, limit 2); stomach: 10 nTPM (protected, limit 2); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1); kidney: 8.8 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 2); parathyroid gland: 6.6 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000166068,SPRED1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.641076,-0.454733,-0.587015
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5292% (minimum 90%, Approved); adrenal gland: 63.0841% (minimum 99%, Missing); amygdala: 48.3871% (minimum 99%, Missing); basal ganglia: 45.0000% (minimum 99%, Missing); bone marrow: 95.0704% (minimum 99%, Missing); cerebellum: 71.0526% (minimum 99%, Missing); cerebral cortex: 40.2985% (minimum 99%, Missing); choroid plexus: 83.8509% (minimum 99%, Missing); colon: 55.1020% (minimum 97%, Missing); duodenum: 62.7907% (minimum 98%, Approved); esophagus: 69.5876% (minimum 97%, Missing); heart muscle: 65.5340% (minimum 99%, Missing); hippocampal formation: 51.1364% (minimum 99%, Missing); hypothalamus: 57.9399% (minimum 99%, Missing); kidney: 60.5381% (minimum 99%, Missing); liver: 71.4286% (minimum 99%, Missing); lung: 44.4079% (minimum 99%, Missing); lymph node: 65.8537% (minimum 95%, Approved); midbrain: 54.2169% (minimum 99%, Missing); pancreas: 75.4190% (minimum 99%, Missing); parathyroid gland: 67.1642% (minimum 97%, Missing); pituitary gland: 77.5862% (minimum 99%, Missing); rectum: 56.0166% (minimum 97%, Missing); retina: 65.2174% (minimum 99%, Missing); salivary gland: 71.4286% (minimum 97%, Missing); skeletal muscle: 83.8509% (minimum 99%, Missing); skin: 69.2308% (minimum 95%, Missing); small intestine: 62.5000% (minimum 99%, Missing); smooth muscle: 59.4714% (minimum 98%, Approved); spinal cord: 53.7849% (minimum 99%, Missing); spleen: 60.5381% (minimum 90%, Approved); stomach: 57.4468% (minimum 97%, Missing); thymus: 75.8427% (minimum 95%, Missing); thyroid gland: 30.8924% (minimum 95%, Missing); tongue: 63.6792% (minimum 97%, Missing); urinary bladder: 51.5267% (minimum 97%, Missing)",0,3,partial,20,12.7,30.2,"thyroid gland: 30.2 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 2); adipose tissue: 12.2 nTPM (manageable, limit 10); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 2); rectum: 10.6 nTPM (protected, limit 2); stomach: 10 nTPM (protected, limit 2); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 2); kidney: 8.8 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 2); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 4); parathyroid gland: 6.6 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 2); liver: 5.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000166068,SPRED1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.641076,-0.454733,-0.587015
True,compatible,,True,True,False,,0,1,partial,0.1,0.6,0,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000166069,TMCO5A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0.6,0,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000166069,TMCO5A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0243978,0.00906191
True,compatible,,True,True,True,,0,1,partial,0.1,0.6,0,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000166069,TMCO5A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00906191
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,77,52.8,22.9,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 2); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 2); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 2); adipose tissue: 22.9 nTPM (manageable, limit 10); small intestine: 21.9 nTPM (vital, limit 2); stomach: 21.7 nTPM (protected, limit 2); esophagus: 21.3 nTPM (protected, limit 2); adrenal gland: 19 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 4); thymus: 17.1 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); tongue: 14.1 nTPM (protected, limit 2); spleen: 13.2 nTPM (manageable, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); salivary gland: 12.9 nTPM (protected, limit 4); skin: 12.6 nTPM (manageable, limit 10); rectum: 12.5 nTPM (protected, limit 4); kidney: 11.1 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 2); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000166086,JAM3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.3670% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.0336% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.1315% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.7285% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.5222% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.5740% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.2942% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.4309% (minimum 99%, Baseline (adaptation disabled)); colon: 65.4450% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.2836% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.4402% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.6284% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 66.0939% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.8725% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.0090% (minimum 99%, Baseline (adaptation disabled)); liver: 96.8992% (minimum 99%, Baseline (adaptation disabled)); lung: 77.7001% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.2509% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.1376% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.2381% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.3971% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.5287% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 68.1199% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.5740% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.6330% (minimum 99%, Baseline (adaptation disabled)); skin: 88.8099% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.0345% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.7714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.4972% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.3392% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.1693% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.3971% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.7303% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.6424% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.2758% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,77,52.8,22.9,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 2); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 2); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 5); small intestine: 21.9 nTPM (vital, limit 1); stomach: 21.7 nTPM (protected, limit 2); esophagus: 21.3 nTPM (protected, limit 2); adrenal gland: 19 nTPM (vital, limit 1); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 17.1 nTPM (protected, limit 2); thyroid gland: 15.3 nTPM (manageable, limit 5); tongue: 14.1 nTPM (protected, limit 2); spleen: 13.2 nTPM (manageable, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); salivary gland: 12.9 nTPM (protected, limit 2); skin: 12.6 nTPM (manageable, limit 5); rectum: 12.5 nTPM (protected, limit 2); kidney: 11.1 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000166086,JAM3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.13633,-0.31555,-0.425028
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.3670% (minimum 90%, Approved); adrenal gland: 84.0336% (minimum 99%, Missing); amygdala: 75.1315% (minimum 99%, Missing); basal ganglia: 68.7285% (minimum 99%, Missing); cerebellum: 88.5740% (minimum 99%, Missing); cerebral cortex: 74.2942% (minimum 99%, Missing); choroid plexus: 67.4309% (minimum 99%, Missing); colon: 65.4450% (minimum 97%, Missing); duodenum: 93.2836% (minimum 99%, Missing); esophagus: 82.4402% (minimum 97%, Missing); heart muscle: 76.6284% (minimum 99%, Missing); hippocampal formation: 66.0939% (minimum 99%, Missing); hypothalamus: 75.8725% (minimum 99%, Missing); kidney: 90.0090% (minimum 99%, Missing); liver: 96.8992% (minimum 99%, Missing); lung: 77.7001% (minimum 98%, Approved); lymph node: 92.2509% (minimum 97%, Missing); midbrain: 66.1376% (minimum 99%, Missing); pancreas: 95.2381% (minimum 99%, Missing); parathyroid gland: 85.3971% (minimum 95%, Approved); pituitary gland: 75.5287% (minimum 99%, Missing); rectum: 88.8889% (minimum 95%, Approved); retina: 68.1199% (minimum 99%, Missing); salivary gland: 88.5740% (minimum 95%, Approved); skeletal muscle: 93.6330% (minimum 98%, Approved); skin: 88.8099% (minimum 90%, Approved); small intestine: 82.0345% (minimum 98%, Approved); smooth muscle: 70.7714% (minimum 99%, Missing); spinal cord: 56.4972% (minimum 99%, Missing); spleen: 88.3392% (minimum 95%, Missing); stomach: 82.1693% (minimum 97%, Missing); thymus: 85.3971% (minimum 95%, Missing); thyroid gland: 86.7303% (minimum 95%, Missing); tongue: 87.6424% (minimum 97%, Missing); urinary bladder: 71.2758% (minimum 97%, Missing)",0,6,partial,77,52.8,22.9,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 2); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 2); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 2); adipose tissue: 22.9 nTPM (manageable, limit 10); small intestine: 21.9 nTPM (vital, limit 2); stomach: 21.7 nTPM (protected, limit 2); esophagus: 21.3 nTPM (protected, limit 2); adrenal gland: 19 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 4); thymus: 17.1 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); tongue: 14.1 nTPM (protected, limit 2); spleen: 13.2 nTPM (manageable, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); salivary gland: 12.9 nTPM (protected, limit 4); skin: 12.6 nTPM (manageable, limit 10); rectum: 12.5 nTPM (protected, limit 4); kidney: 11.1 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 2); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 2); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000166086,JAM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.096029,-0.31555,-0.425028
True,compatible,,True,True,False,,0,3,partial,0.2,0.2,0,,,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000166118,SPATA19,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0.2,0.2,0,,,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000166118,SPATA19,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0284744,0.00847445
True,compatible,,True,True,True,,0,3,partial,0.2,0.2,0,,,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000166118,SPATA19,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00847445
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000166152,C16orf78,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000166152,C16orf78,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000166152,C16orf78,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,6.1,5.5,4.9,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 2); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); hypothalamus: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166192,SENP8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.8272% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.9408% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.8889% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.8613% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.4444% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.0180% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.4444% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.4762% (minimum 99%, Baseline (adaptation disabled)); colon: 88.8889% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.9408% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.3563% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.4762% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.8571% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.9487% (minimum 99%, Baseline (adaptation disabled)); liver: 86.3636% (minimum 99%, Baseline (adaptation disabled)); lung: 91.5663% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.0180% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.3563% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.0180% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.8571% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.8613% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 77.1574% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.4762% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.3615% (minimum 99%, Baseline (adaptation disabled)); skin: 91.0180% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.5663% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.0180% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.9408% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.5663% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.3721% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.0180% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.6219% (minimum 95%, Baseline (adaptation disabled)); tongue: 73.4300% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.4762% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,6.1,5.5,4.9,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 2); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); hypothalamus: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166192,SENP8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.193781,-0.2357,-0.276385
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.8272% (minimum 95%, Missing); adrenal gland: 89.9408% (minimum 99%, Missing); amygdala: 88.8889% (minimum 99%, Missing); basal ganglia: 87.8613% (minimum 99%, Missing); bone marrow: 84.4444% (minimum 99%, Missing); cerebellum: 91.0180% (minimum 99%, Missing); cerebral cortex: 84.4444% (minimum 99%, Missing); choroid plexus: 90.4762% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); duodenum: 89.9408% (minimum 99%, Missing); esophagus: 87.3563% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 86.8571% (minimum 99%, Missing); kidney: 77.9487% (minimum 99%, Missing); liver: 86.3636% (minimum 99%, Missing); lung: 91.5663% (minimum 99%, Missing); lymph node: 91.0180% (minimum 97%, Missing); midbrain: 87.3563% (minimum 99%, Missing); pancreas: 91.0180% (minimum 99%, Missing); parathyroid gland: 86.8571% (minimum 97%, Missing); pituitary gland: 87.8613% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 77.1574% (minimum 99%, Missing); salivary gland: 90.4762% (minimum 97%, Missing); skeletal muscle: 71.3615% (minimum 99%, Missing); skin: 91.0180% (minimum 95%, Missing); small intestine: 91.5663% (minimum 99%, Missing); smooth muscle: 91.0180% (minimum 99%, Missing); spinal cord: 89.9408% (minimum 99%, Missing); spleen: 91.5663% (minimum 95%, Missing); stomach: 88.3721% (minimum 97%, Missing); thymus: 91.0180% (minimum 95%, Missing); thyroid gland: 75.6219% (minimum 95%, Missing); tongue: 73.4300% (minimum 97%, Missing); urinary bladder: 90.4762% (minimum 97%, Missing)",0,1,partial,6.1,5.5,4.9,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 2); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); hypothalamus: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166192,SENP8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.193781,-0.2357,-0.276385
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,45.7,5.5,8.3,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166206,GABRB3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.4615% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 46.9388% (minimum 99%, Baseline (adaptation disabled)); amygdala: 58.9744% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 32.8571% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 31.9444% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 9.1451% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.8776% (minimum 99%, Baseline (adaptation disabled)); colon: 80.7018% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.1852% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.7018% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 47.4227% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 53.4884% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 43.8095% (minimum 99%, Baseline (adaptation disabled)); kidney: 39.6552% (minimum 99%, Baseline (adaptation disabled)); liver: 90.1961% (minimum 99%, Baseline (adaptation disabled)); lung: 85.1852% (minimum 99%, Baseline (adaptation disabled)); midbrain: 74.1935% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.9744% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.6970% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 45.0980% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.6364% (minimum 97%, Baseline (adaptation disabled)); retina: 13.5693% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.1961% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.8723% (minimum 99%, Baseline (adaptation disabled)); skin: 86.7925% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.4615% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 79.3103% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.6364% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.4615% (minimum 95%, Baseline (adaptation disabled)); stomach: 45.5446% (minimum 97%, Baseline (adaptation disabled)); thymus: 76.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 35.6589% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 82.1429% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,45.7,5.5,8.3,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166206,GABRB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.593411,-0.514554,-0.898549
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.4615% (minimum 95%, Missing); adrenal gland: 46.9388% (minimum 99%, Missing); amygdala: 58.9744% (minimum 99%, Missing); basal ganglia: 32.8571% (minimum 99%, Missing); cerebellum: 31.9444% (minimum 99%, Missing); cerebral cortex: 9.1451% (minimum 99%, Missing); choroid plexus: 93.8776% (minimum 99%, Missing); colon: 80.7018% (minimum 97%, Missing); duodenum: 85.1852% (minimum 99%, Missing); esophagus: 80.7018% (minimum 97%, Missing); heart muscle: 47.4227% (minimum 99%, Missing); hippocampal formation: 53.4884% (minimum 99%, Missing); hypothalamus: 43.8095% (minimum 99%, Missing); kidney: 39.6552% (minimum 99%, Missing); liver: 90.1961% (minimum 99%, Missing); lung: 85.1852% (minimum 99%, Missing); midbrain: 74.1935% (minimum 99%, Missing); pancreas: 58.9744% (minimum 99%, Missing); parathyroid gland: 69.6970% (minimum 97%, Missing); pituitary gland: 45.0980% (minimum 99%, Missing); rectum: 83.6364% (minimum 97%, Missing); retina: 13.5693% (minimum 99%, Missing); salivary gland: 90.1961% (minimum 97%, Missing); skeletal muscle: 97.8723% (minimum 99%, Missing); skin: 86.7925% (minimum 95%, Missing); small intestine: 88.4615% (minimum 99%, Missing); smooth muscle: 79.3103% (minimum 99%, Missing); spinal cord: 83.6364% (minimum 99%, Missing); spleen: 88.4615% (minimum 95%, Missing); stomach: 45.5446% (minimum 97%, Missing); thymus: 76.6667% (minimum 95%, Missing); thyroid gland: 35.6589% (minimum 95%, Missing); urinary bladder: 82.1429% (minimum 97%, Missing)",0,80,unavailable,45.7,5.5,8.3,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 2); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166206,GABRB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.593411,-0.514554,-0.898549
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.1,0,125.3,"thymus: 125.3 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,ENSG00000166220,TBATA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 13.9423% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,125.3,"thymus: 125.3 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,ENSG00000166220,TBATA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,-0.810577,0.03,0.00509804
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 13.9423% (minimum 95%, Missing)",0,80,unavailable,0.1,0,125.3,"thymus: 125.3 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,ENSG00000166220,TBATA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,-0.810577,0.03,0.00509804
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,11.2,1.1,1.9,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166246,DNAAF8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.3584% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.6902% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.7699% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.3584% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.8231% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.5223% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.8996% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.9003% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.3807% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.6902% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2240% (minimum 99%, Baseline (adaptation disabled)); lung: 96.3807% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.4255% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6283% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.7299% (minimum 99%, Baseline (adaptation disabled)); retina: 97.6902% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.7637% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.8996% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0900% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,11.2,1.1,1.9,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166246,DNAAF8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0242547,0.0149315,-0.124777
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.6902% (minimum 99%, Missing); basal ganglia: 96.7699% (minimum 99%, Missing); choroid plexus: 86.5223% (minimum 99%, Missing); hippocampal formation: 96.9003% (minimum 99%, Missing); hypothalamus: 96.3807% (minimum 99%, Missing); kidney: 97.6902% (minimum 99%, Missing); midbrain: 97.4255% (minimum 99%, Missing); pituitary gland: 94.7299% (minimum 99%, Missing); retina: 97.6902% (minimum 99%, Missing); spinal cord: 98.0900% (minimum 99%, Missing)",0,6,partial,11.2,1.1,1.9,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166246,DNAAF8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0417241,0.0149315,-0.124777
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,4.4,5.8,3,"parathyroid gland: 5.8 nTPM (protected, limit 2); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166263,STXBP4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.8333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.1509% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.9268% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.9524% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 70.8333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.9130% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.7143% (minimum 99%, Baseline (adaptation disabled)); colon: 68.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.6271% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.3846% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.9268% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.0698% (minimum 99%, Baseline (adaptation disabled)); kidney: 44.7368% (minimum 99%, Baseline (adaptation disabled)); liver: 79.0698% (minimum 99%, Baseline (adaptation disabled)); lung: 61.8182% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.9130% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.9524% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.3878% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 36.9565% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.1509% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 43.5897% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.8333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 75.5556% (minimum 99%, Baseline (adaptation disabled)); skin: 77.2727% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.3404% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.0698% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.2727% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.3878% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.3846% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.1250% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.2727% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.3846% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,4.4,5.8,3,"parathyroid gland: 5.8 nTPM (protected, limit 2); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166263,STXBP4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.41875,-0.600435,-0.554103
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.8333% (minimum 95%, Missing); adrenal gland: 64.1509% (minimum 99%, Missing); amygdala: 82.9268% (minimum 99%, Missing); basal ganglia: 80.9524% (minimum 99%, Missing); bone marrow: 70.8333% (minimum 99%, Missing); cerebellum: 85.0000% (minimum 99%, Missing); cerebral cortex: 73.9130% (minimum 99%, Missing); choroid plexus: 60.7143% (minimum 99%, Missing); colon: 68.0000% (minimum 97%, Missing); duodenum: 57.6271% (minimum 99%, Missing); esophagus: 65.3846% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 82.9268% (minimum 99%, Missing); hypothalamus: 79.0698% (minimum 99%, Missing); kidney: 44.7368% (minimum 99%, Missing); liver: 79.0698% (minimum 99%, Missing); lung: 61.8182% (minimum 99%, Missing); lymph node: 73.9130% (minimum 97%, Missing); midbrain: 80.9524% (minimum 99%, Missing); pancreas: 69.3878% (minimum 99%, Missing); parathyroid gland: 36.9565% (minimum 97%, Missing); pituitary gland: 64.1509% (minimum 99%, Missing); rectum: 68.0000% (minimum 97%, Missing); retina: 43.5897% (minimum 99%, Missing); salivary gland: 70.8333% (minimum 97%, Missing); skeletal muscle: 75.5556% (minimum 99%, Missing); skin: 77.2727% (minimum 95%, Missing); small intestine: 72.3404% (minimum 99%, Missing); smooth muscle: 56.6667% (minimum 99%, Missing); spinal cord: 79.0698% (minimum 99%, Missing); spleen: 77.2727% (minimum 95%, Missing); stomach: 69.3878% (minimum 97%, Missing); thymus: 65.3846% (minimum 95%, Missing); thyroid gland: 53.1250% (minimum 95%, Missing); tongue: 77.2727% (minimum 97%, Missing); urinary bladder: 65.3846% (minimum 97%, Missing)",0,1,partial,4.4,5.8,3,"parathyroid gland: 5.8 nTPM (protected, limit 2); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166263,STXBP4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.41875,-0.600435,-0.554103
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.7,0.9,1.7,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166323,C11orf65,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2036% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.9940% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.9940% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7952% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.5972% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5972% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0938% (minimum 99%, Baseline (adaptation disabled)); liver: 95.1644% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.9940% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2036% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.9940% (minimum 99%, Baseline (adaptation disabled)); retina: 94.7977% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.9940% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5972% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.7,0.9,1.7,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166323,C11orf65,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0166012,0.0120359,-0.0420231
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2036% (minimum 99%, Missing); amygdala: 98.9940% (minimum 99%, Missing); basal ganglia: 98.9940% (minimum 99%, Missing); cerebral cortex: 98.7952% (minimum 99%, Missing); choroid plexus: 98.5972% (minimum 99%, Missing); heart muscle: 98.5972% (minimum 99%, Missing); kidney: 96.0938% (minimum 99%, Missing); liver: 95.1644% (minimum 99%, Missing); midbrain: 98.9940% (minimum 99%, Missing); pancreas: 98.2036% (minimum 99%, Missing); pituitary gland: 98.9940% (minimum 99%, Missing); retina: 94.7977% (minimum 99%, Missing); skeletal muscle: 98.9940% (minimum 99%, Missing); spinal cord: 98.5972% (minimum 99%, Missing)",0,80,unavailable,2.7,0.9,1.7,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166323,C11orf65,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0166012,0.0120359,-0.0420231
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000166329,CCDC182,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000166329,CCDC182,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.00640288
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000166329,CCDC182,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.00640288
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,4.2,0.6,385,"thymus: 385 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166349,RAG1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.5385% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 16.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.8889% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 38.0952% (minimum 99%, Baseline (adaptation disabled)); liver: 53.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 57.1429% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8889% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.8889% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.7273% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.1429% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.7273% (minimum 97%, Baseline (adaptation disabled)); retina: 57.1429% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); skin: 88.8889% (minimum 95%, Baseline (adaptation disabled)); small intestine: 44.4444% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spleen: 22.8571% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.5385% (minimum 97%, Baseline (adaptation disabled)); thymus: 0.2074% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 25.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 72.7273% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.7273% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.2,0.6,385,"thymus: 385 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166349,RAG1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.947926,-0.398571,-0.83
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 61.5385% (minimum 99%, Missing); bone marrow: 16.0000% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 88.8889% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); kidney: 38.0952% (minimum 99%, Missing); liver: 53.3333% (minimum 99%, Missing); lung: 57.1429% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); midbrain: 88.8889% (minimum 99%, Missing); pancreas: 72.7273% (minimum 99%, Missing); parathyroid gland: 57.1429% (minimum 97%, Missing); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 72.7273% (minimum 97%, Missing); retina: 57.1429% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 88.8889% (minimum 99%, Missing); skin: 88.8889% (minimum 95%, Missing); small intestine: 44.4444% (minimum 99%, Missing); smooth muscle: 88.8889% (minimum 99%, Missing); spinal cord: 88.8889% (minimum 99%, Missing); spleen: 22.8571% (minimum 95%, Missing); stomach: 61.5385% (minimum 97%, Missing); thymus: 0.2074% (minimum 95%, Missing); thyroid gland: 25.0000% (minimum 95%, Missing); tongue: 72.7273% (minimum 97%, Missing); urinary bladder: 72.7273% (minimum 97%, Missing)",0,80,unavailable,4.2,0.6,385,"thymus: 385 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166349,RAG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.947926,-0.398571,-0.83
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000166351,POTED,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.6744% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.6744% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6744% (minimum 99%, Baseline (adaptation disabled)); retina: 95.4545% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.6744% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000166351,POTED,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.00454545,0.00674419,-0.0354545
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.6744% (minimum 99%, Missing); heart muscle: 97.6744% (minimum 99%, Missing); lung: 97.6744% (minimum 99%, Missing); retina: 95.4545% (minimum 99%, Missing); skeletal muscle: 97.6744% (minimum 99%, Missing)",0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000166351,POTED,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.00454545,0.00674419,-0.0354545
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,1.2,0.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000166359,WDR88,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5556% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.8506% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.6292% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.5263% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.6292% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.5263% (minimum 99%, Baseline (adaptation disabled)); duodenum: 93.4783% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.4783% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.5263% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.7273% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8506% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.6292% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8506% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7273% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.7551% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.8506% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.4731% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.7273% (minimum 99%, Baseline (adaptation disabled)); retina: 85.1485% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.4731% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.7273% (minimum 99%, Baseline (adaptation disabled)); skin: 92.4731% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.4731% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8506% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.5055% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.6292% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 90.5263% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.5,1.2,0.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000166359,WDR88,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,-0.0447368,-0.092449,-0.138515
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.5556% (minimum 99%, Missing); amygdala: 98.8506% (minimum 99%, Missing); basal ganglia: 96.6292% (minimum 99%, Missing); bone marrow: 90.5263% (minimum 99%, Missing); cerebellum: 96.6292% (minimum 99%, Missing); cerebral cortex: 90.5263% (minimum 99%, Missing); duodenum: 93.4783% (minimum 99%, Missing); esophagus: 93.4783% (minimum 97%, Missing); heart muscle: 90.5263% (minimum 99%, Missing); hippocampal formation: 97.7273% (minimum 99%, Missing); hypothalamus: 98.8506% (minimum 99%, Missing); kidney: 96.6292% (minimum 99%, Missing); liver: 98.8506% (minimum 99%, Missing); lung: 97.7273% (minimum 99%, Missing); lymph node: 87.7551% (minimum 97%, Missing); midbrain: 98.8506% (minimum 99%, Missing); pancreas: 92.4731% (minimum 99%, Missing); pituitary gland: 97.7273% (minimum 99%, Missing); retina: 85.1485% (minimum 99%, Missing); salivary gland: 92.4731% (minimum 97%, Missing); skeletal muscle: 97.7273% (minimum 99%, Missing); skin: 92.4731% (minimum 95%, Missing); small intestine: 92.4731% (minimum 99%, Missing); spinal cord: 98.8506% (minimum 99%, Missing); spleen: 94.5055% (minimum 95%, Missing); stomach: 96.6292% (minimum 97%, Missing); thyroid gland: 90.5263% (minimum 95%, Missing)",0,80,unavailable,1.5,1.2,0.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000166359,WDR88,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,-0.0447368,-0.092449,-0.138515
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000166368,OR2D2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000166368,OR2D2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000166368,OR2D2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,14.3,9.8,7.5,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 2); thymus: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 2); skin: 5.4 nTPM (manageable, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 2); liver: 4.9 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166439,RNF169,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.9123% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.5490% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.2222% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 34.1014% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 63.7931% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.4867% (minimum 99%, Baseline (adaptation disabled)); esophagus: 43.0233% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.4762% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.2222% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.0909% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.1849% (minimum 99%, Baseline (adaptation disabled)); liver: 60.1626% (minimum 99%, Baseline (adaptation disabled)); lung: 56.4885% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.4118% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.1461% (minimum 99%, Baseline (adaptation disabled)); pancreas: 63.2479% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.8125% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.7234% (minimum 99%, Baseline (adaptation disabled)); rectum: 59.2000% (minimum 97%, Baseline (adaptation disabled)); retina: 55.6391% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.7119% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 53.2374% (minimum 99%, Baseline (adaptation disabled)); skin: 57.8125% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.2479% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 50.3401% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.8947% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.6849% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.1849% (minimum 97%, Baseline (adaptation disabled)); thymus: 49.6644% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.4885% (minimum 95%, Baseline (adaptation disabled)); tongue: 56.9231% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.6774% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,14.3,9.8,7.5,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 2); thymus: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 2); skin: 5.4 nTPM (manageable, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 2); liver: 4.9 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166439,RNF169,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.453356,-0.539767,-0.648986
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.9123% (minimum 95%, Missing); adrenal gland: 72.5490% (minimum 99%, Missing); amygdala: 82.2222% (minimum 99%, Missing); basal ganglia: 82.2222% (minimum 99%, Missing); bone marrow: 34.1014% (minimum 99%, Missing); cerebellum: 74.0000% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 63.7931% (minimum 97%, Missing); duodenum: 65.4867% (minimum 99%, Missing); esophagus: 43.0233% (minimum 97%, Missing); heart muscle: 70.4762% (minimum 99%, Missing); hippocampal formation: 82.2222% (minimum 99%, Missing); hypothalamus: 84.0909% (minimum 99%, Missing); kidney: 62.1849% (minimum 99%, Missing); liver: 60.1626% (minimum 99%, Missing); lung: 56.4885% (minimum 99%, Missing); lymph node: 54.4118% (minimum 97%, Missing); midbrain: 83.1461% (minimum 99%, Missing); pancreas: 63.2479% (minimum 99%, Missing); parathyroid gland: 57.8125% (minimum 97%, Missing); pituitary gland: 78.7234% (minimum 99%, Missing); rectum: 59.2000% (minimum 97%, Missing); retina: 55.6391% (minimum 99%, Missing); salivary gland: 62.7119% (minimum 97%, Missing); skeletal muscle: 53.2374% (minimum 99%, Missing); skin: 57.8125% (minimum 95%, Missing); small intestine: 63.2479% (minimum 99%, Missing); smooth muscle: 50.3401% (minimum 99%, Missing); spinal cord: 77.8947% (minimum 99%, Missing); spleen: 50.6849% (minimum 95%, Missing); stomach: 62.1849% (minimum 97%, Missing); thymus: 49.6644% (minimum 95%, Missing); thyroid gland: 56.4885% (minimum 95%, Missing); tongue: 56.9231% (minimum 97%, Missing); urinary bladder: 59.6774% (minimum 97%, Missing)",0,80,unavailable,14.3,9.8,7.5,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 2); thymus: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 2); skin: 5.4 nTPM (manageable, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 2); rectum: 5.1 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 2); liver: 4.9 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); small intestine: 4.3 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166439,RNF169,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.453356,-0.539767,-0.648986
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.2,0.5,0.6,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000166546,BEAN1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.6364% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 63.6364% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 38.8889% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 87.5000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.7778% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 56.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.3529% (minimum 99%, Baseline (adaptation disabled)); liver: 82.3529% (minimum 99%, Baseline (adaptation disabled)); lung: 82.3529% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.7778% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.3333% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.6842% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); retina: 58.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.3529% (minimum 97%, Baseline (adaptation disabled)); skin: 70.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.3529% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.3333% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 82.3529% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.3333% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.5000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.2,0.5,0.6,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000166546,BEAN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.25,-0.233158,-0.601111
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Missing); adrenal gland: 93.3333% (minimum 99%, Missing); amygdala: 63.6364% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); cerebellum: 63.6364% (minimum 99%, Missing); cerebral cortex: 38.8889% (minimum 99%, Missing); choroid plexus: 93.3333% (minimum 99%, Missing); colon: 87.5000% (minimum 97%, Missing); duodenum: 93.3333% (minimum 99%, Missing); esophagus: 77.7778% (minimum 97%, Missing); heart muscle: 70.0000% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 56.0000% (minimum 99%, Missing); kidney: 82.3529% (minimum 99%, Missing); liver: 82.3529% (minimum 99%, Missing); lung: 82.3529% (minimum 99%, Missing); lymph node: 93.3333% (minimum 97%, Missing); midbrain: 77.7778% (minimum 99%, Missing); pancreas: 93.3333% (minimum 99%, Missing); parathyroid gland: 73.6842% (minimum 97%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); retina: 58.3333% (minimum 99%, Missing); salivary gland: 82.3529% (minimum 97%, Missing); skin: 70.0000% (minimum 95%, Missing); small intestine: 93.3333% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spinal cord: 82.3529% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Missing); stomach: 93.3333% (minimum 97%, Missing); thyroid gland: 82.3529% (minimum 95%, Missing); tongue: 93.3333% (minimum 97%, Missing); urinary bladder: 87.5000% (minimum 97%, Missing)",0,80,unavailable,2.2,0.5,0.6,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000166546,BEAN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.25,-0.233158,-0.601111
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,21.4,4.9,1.7,"choroid plexus: 21.4 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166578,IQCD,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9499% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.1327% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.0736% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.3982% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.8468% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.7702% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.9821% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.0655% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.2982% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.4783% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.8865% (minimum 99%, Baseline (adaptation disabled)); lung: 94.5055% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.1327% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7273% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.7704% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.8803% (minimum 99%, Baseline (adaptation disabled)); retina: 92.2747% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.9499% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.5055% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 95.9821% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,21.4,4.9,1.7,"choroid plexus: 21.4 nTPM (vital, limit 1); parathyroid gland: 4.9 nTPM (protected, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166578,IQCD,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0119687,-0.0722965,-0.322298
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.1327% (minimum 99%, Missing); basal ganglia: 93.0736% (minimum 99%, Missing); cerebral cortex: 96.8468% (minimum 97%, Supported); choroid plexus: 66.7702% (minimum 99%, Missing); hippocampal formation: 94.2982% (minimum 99%, Missing); hypothalamus: 93.4783% (minimum 99%, Missing); kidney: 93.8865% (minimum 97%, Supported); lung: 94.5055% (minimum 97%, Supported); midbrain: 95.1327% (minimum 99%, Missing); parathyroid gland: 89.7704% (minimum 90%, Supported); pituitary gland: 91.8803% (minimum 99%, Missing); retina: 92.2747% (minimum 99%, Missing); spinal cord: 94.5055% (minimum 99%, Missing)",0,4,partial,21.4,4.9,1.7,"choroid plexus: 21.4 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166578,IQCD,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0339817,-0.00229645,-0.322298
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.8,2.2,2,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166743,ACSM1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.3560% (minimum 99%, Baseline (adaptation disabled)); liver: 95.5292% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,9.8,2.2,2,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166743,ACSM1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0405393,0.019603,-0.034708
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.3560% (minimum 99%, Missing); liver: 95.5292% (minimum 99%, Missing)",0,80,unavailable,9.8,2.2,2,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166743,ACSM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0405393,0.019603,-0.034708
True,compatible,,True,True,False,,0,2,partial,1.4,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166796,LDHC,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,2,partial,1.4,0.4,0.5,"liver: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166796,LDHC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0480613,0.0284484,0.00459042
True,compatible,,True,True,True,,0,2,partial,1.4,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166796,LDHC,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0492236,0.0292236,0.00883586
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.4,0.9,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166800,LDHAL6A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.6989% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.8889% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.8990% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.6809% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.7391% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.8022% (minimum 99%, Baseline (adaptation disabled)); duodenum: 93.6842% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.8889% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8889% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8889% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8889% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8889% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.6989% (minimum 97%, Baseline (adaptation disabled)); pancreas: 96.7391% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.8889% (minimum 99%, Baseline (adaptation disabled)); retina: 89.0000% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.8889% (minimum 99%, Baseline (adaptation disabled)); skin: 90.8163% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.6809% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 94.6809% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.4,0.9,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166800,LDHAL6A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0418367,-0.0130108,-0.1
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.6989% (minimum 99%, Missing); amygdala: 98.8889% (minimum 99%, Missing); bone marrow: 89.8990% (minimum 99%, Missing); cerebellum: 94.6809% (minimum 99%, Missing); cerebral cortex: 96.7391% (minimum 99%, Missing); choroid plexus: 97.8022% (minimum 99%, Missing); duodenum: 93.6842% (minimum 99%, Missing); heart muscle: 98.8889% (minimum 99%, Missing); hippocampal formation: 98.8889% (minimum 99%, Missing); hypothalamus: 98.8889% (minimum 99%, Missing); kidney: 98.8889% (minimum 99%, Missing); lung: 98.8889% (minimum 99%, Missing); lymph node: 95.6989% (minimum 97%, Missing); pancreas: 96.7391% (minimum 99%, Missing); pituitary gland: 98.8889% (minimum 99%, Missing); retina: 89.0000% (minimum 99%, Missing); skeletal muscle: 98.8889% (minimum 99%, Missing); skin: 90.8163% (minimum 95%, Missing); small intestine: 94.6809% (minimum 99%, Missing); thyroid gland: 94.6809% (minimum 95%, Missing)",0,80,unavailable,1.1,0.4,0.9,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166800,LDHAL6A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0418367,-0.0130108,-0.1
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.4,2.9,3.4,"lymph node: 2.9 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166845,C18orf54,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.3617% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.5517% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.9153% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.9153% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.4545% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.3226% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.2456% (minimum 99%, Baseline (adaptation disabled)); colon: 92.3077% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.4545% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.3820% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.9153% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.4545% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2456% (minimum 99%, Baseline (adaptation disabled)); lung: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.2792% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.8033% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.8235% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.5517% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.8235% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.8177% (minimum 97%, Baseline (adaptation disabled)); retina: 93.8547% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.2456% (minimum 99%, Baseline (adaptation disabled)); skin: 94.3820% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.4545% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.8108% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.5000% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.3043% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.4545% (minimum 97%, Baseline (adaptation disabled)); thymus: 83.1683% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.9153% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.8547% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.9153% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.4,2.9,3.4,"lymph node: 2.9 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166845,C18orf54,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.118317,-0.117208,-0.115
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.3617% (minimum 95%, Missing); adrenal gland: 96.5517% (minimum 99%, Missing); amygdala: 94.9153% (minimum 99%, Missing); basal ganglia: 94.9153% (minimum 99%, Missing); bone marrow: 93.3333% (minimum 99%, Missing); cerebellum: 95.4545% (minimum 99%, Missing); cerebral cortex: 90.3226% (minimum 99%, Missing); choroid plexus: 98.2456% (minimum 99%, Missing); colon: 92.3077% (minimum 97%, Missing); duodenum: 95.4545% (minimum 99%, Missing); esophagus: 94.3820% (minimum 97%, Missing); heart muscle: 94.9153% (minimum 99%, Missing); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); kidney: 96.0000% (minimum 99%, Missing); liver: 98.2456% (minimum 99%, Missing); lung: 93.3333% (minimum 99%, Missing); lymph node: 85.2792% (minimum 97%, Missing); midbrain: 91.8033% (minimum 99%, Missing); pancreas: 98.8235% (minimum 99%, Missing); parathyroid gland: 96.5517% (minimum 97%, Missing); pituitary gland: 98.8235% (minimum 99%, Missing); rectum: 92.8177% (minimum 97%, Missing); retina: 93.8547% (minimum 99%, Missing); skeletal muscle: 98.2456% (minimum 99%, Missing); skin: 94.3820% (minimum 95%, Missing); small intestine: 95.4545% (minimum 99%, Missing); smooth muscle: 90.8108% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 91.3043% (minimum 95%, Missing); stomach: 95.4545% (minimum 97%, Missing); thymus: 83.1683% (minimum 95%, Missing); thyroid gland: 94.9153% (minimum 95%, Missing); tongue: 93.8547% (minimum 97%, Missing); urinary bladder: 94.9153% (minimum 97%, Missing)",0,80,unavailable,2.4,2.9,3.4,"lymph node: 2.9 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166845,C18orf54,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.118317,-0.117208,-0.115
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,31.6,27.2,42.7,"thymus: 42.7 nTPM (manageable, limit 5); bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 2); esophagus: 13.5 nTPM (protected, limit 2); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 2); colon: 9.3 nTPM (protected, limit 2); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); skin: 5.6 nTPM (manageable, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166851,PLK1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.5357% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.5357% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.5860% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 50.3925% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.4530% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.6903% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.8659% (minimum 99%, Baseline (adaptation disabled)); colon: 77.5362% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.0664% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.3947% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.9789% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.5357% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1078% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.8209% (minimum 99%, Baseline (adaptation disabled)); liver: 94.6903% (minimum 99%, Baseline (adaptation disabled)); lung: 94.4118% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.1315% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.3964% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.6867% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.3964% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.6110% (minimum 97%, Baseline (adaptation disabled)); retina: 96.3964% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.3140% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.2727% (minimum 99%, Baseline (adaptation disabled)); skin: 85.1459% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.2927% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.4150% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.6867% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.2927% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.2520% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.9144% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.2414% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,31.6,27.2,42.7,"thymus: 42.7 nTPM (manageable, limit 5); bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 2); esophagus: 13.5 nTPM (protected, limit 2); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 2); colon: 9.3 nTPM (protected, limit 2); spleen: 8.9 nTPM (manageable, limit 5); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); skin: 5.6 nTPM (manageable, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166851,PLK1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.520856,-0.428685,-0.486075
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 95.5357% (minimum 99%, Missing); amygdala: 95.5357% (minimum 99%, Missing); basal ganglia: 93.5860% (minimum 99%, Missing); bone marrow: 50.3925% (minimum 99%, Missing); cerebellum: 91.4530% (minimum 99%, Missing); cerebral cortex: 94.6903% (minimum 99%, Missing); choroid plexus: 97.8659% (minimum 99%, Missing); colon: 77.5362% (minimum 97%, Missing); duodenum: 76.0664% (minimum 99%, Missing); esophagus: 70.3947% (minimum 97%, Missing); heart muscle: 96.9789% (minimum 99%, Missing); hippocampal formation: 95.5357% (minimum 99%, Missing); hypothalamus: 96.1078% (minimum 99%, Missing); kidney: 95.8209% (minimum 99%, Missing); liver: 94.6903% (minimum 99%, Missing); lung: 94.4118% (minimum 99%, Missing); lymph node: 54.1315% (minimum 97%, Missing); midbrain: 96.3964% (minimum 99%, Missing); pancreas: 96.6867% (minimum 99%, Missing); pituitary gland: 96.3964% (minimum 99%, Missing); rectum: 76.6110% (minimum 97%, Missing); retina: 96.3964% (minimum 99%, Missing); salivary gland: 93.3140% (minimum 97%, Missing); skeletal muscle: 97.2727% (minimum 99%, Missing); skin: 85.1459% (minimum 95%, Missing); small intestine: 78.2927% (minimum 99%, Missing); smooth muscle: 89.4150% (minimum 99%, Missing); spinal cord: 96.6867% (minimum 99%, Missing); spleen: 78.2927% (minimum 90%, Approved); stomach: 84.2520% (minimum 97%, Missing); thymus: 42.9144% (minimum 95%, Missing); urinary bladder: 92.2414% (minimum 97%, Missing)",0,4,partial,31.6,27.2,42.7,"thymus: 42.7 nTPM (manageable, limit 5); bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 2); esophagus: 13.5 nTPM (protected, limit 2); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 2); colon: 9.3 nTPM (protected, limit 2); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 2); skin: 5.6 nTPM (manageable, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000166851,PLK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.520856,-0.428685,-0.486075
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000166884,OR4D6,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000166884,OR4D6,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000166884,OR4D6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.6,0.2,3.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen,ENSG00000166926,MS4A6E,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 90.8676% (minimum 95%, Baseline (adaptation disabled)); lung: 97.0732% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.0427% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.2,3.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen,ENSG00000166926,MS4A6E,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.0995726,0.0200498,-0.0192683
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 90.8676% (minimum 95%, Missing); lung: 97.0732% (minimum 99%, Missing); spleen: 85.0427% (minimum 95%, Missing)",0,80,unavailable,0.6,0.2,3.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen,ENSG00000166926,MS4A6E,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.0995726,0.0200498,-0.0192683
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,11.6,2.6,10.2,"lung: 11.6 nTPM (vital, limit 6); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166928,MS4A14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.5441% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.1743% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.5275% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2019% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.3380% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.7913% (minimum 99%, Baseline (adaptation disabled)); colon: 96.4674% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.5986% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.9945% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.1272% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5275% (minimum 99%, Baseline (adaptation disabled)); liver: 97.3937% (minimum 99%, Baseline (adaptation disabled)); lung: 85.9564% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.5986% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.3380% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.0663% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.7483% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.4674% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.3380% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.4384% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,11.6,2.6,10.2,"lung: 11.6 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); small intestine: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166928,MS4A14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0756158,-0.00532609,-0.130436
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.5275% (minimum 99%, Missing); basal ganglia: 98.2019% (minimum 99%, Missing); choroid plexus: 93.7913% (minimum 99%, Missing); hippocampal formation: 96.9945% (minimum 99%, Missing); hypothalamus: 97.1272% (minimum 99%, Missing); lung: 85.9564% (minimum 95%, Enhanced); midbrain: 96.5986% (minimum 99%, Missing); pituitary gland: 98.0663% (minimum 99%, Missing); spinal cord: 94.6667% (minimum 99%, Missing)",0,1,partial,11.6,2.6,10.2,"lung: 11.6 nTPM (vital, limit 6); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000166928,MS4A14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0457924,0.0257924,-0.0904358
True,compatible,,True,True,False,,0,0,routine_complete,0.2,0,0,,,55,not_established,not_triggered,,,ENSG00000166930,MS4A5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,0,routine_complete,0.2,0,0,,,55,not_established,not_triggered,,,ENSG00000166930,MS4A5,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.0054023
True,compatible,,True,True,True,,0,0,routine_complete,0.2,0,0,,,55,not_established,not_triggered,,,ENSG00000166930,MS4A5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.0054023
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.9,0,0,"liver: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000167014,TERB2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 91.8103% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.9,0,0,"liver: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000167014,TERB2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0718966
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 91.8103% (minimum 99%, Missing)",0,80,unavailable,1.9,0,0,"liver: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000167014,TERB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0718966
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.4,0.1,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,ENSG00000167094,TTC16,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.7261% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.3735% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.7261% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7261% (minimum 99%, Baseline (adaptation disabled)); lung: 95.6790% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.4,0.1,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,ENSG00000167094,TTC16,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,0.0435897,0.00484277,-0.0562651
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.7261% (minimum 99%, Missing); choroid plexus: 93.3735% (minimum 99%, Missing); hippocampal formation: 98.7261% (minimum 99%, Missing); hypothalamus: 98.7261% (minimum 99%, Missing); lung: 95.6790% (minimum 99%, Missing)",0,80,unavailable,1.1,0.4,0.1,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,ENSG00000167094,TTC16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,0.0435897,0.00484277,-0.0562651
True,compatible,,True,True,False,,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000167098,SUN5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000167098,SUN5,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000167098,SUN5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000167139,TBC1D21,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000167139,TBC1D21,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000167139,TBC1D21,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,34.7,0.1,0,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000167194,C16orf92,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.5466% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.3856% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0263% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0263% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.1250% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.6905% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.7532% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.0263% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.6755% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.0263% (minimum 99%, Baseline (adaptation disabled)); retina: 30.0403% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,34.7,0.1,0,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000167194,C16orf92,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.0233333,-0.689597
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.5466% (minimum 99%, Missing); amygdala: 97.3856% (minimum 99%, Missing); basal ganglia: 98.0263% (minimum 99%, Missing); bone marrow: 98.0263% (minimum 99%, Missing); cerebellum: 93.1250% (minimum 99%, Missing); cerebral cortex: 88.6905% (minimum 99%, Missing); hippocampal formation: 96.7532% (minimum 99%, Missing); hypothalamus: 98.0263% (minimum 99%, Missing); midbrain: 98.6755% (minimum 99%, Missing); pituitary gland: 98.0263% (minimum 99%, Missing); retina: 30.0403% (minimum 99%, Missing)",0,80,unavailable,34.7,0.1,0,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000167194,C16orf92,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.0233333,-0.689597
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,3.7,0.1,0.2,"liver: 3.7 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000167195,GOLGA6C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9796% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.9798% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.9798% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.9796% (minimum 99%, Baseline (adaptation disabled)); liver: 72.3881% (minimum 99%, Baseline (adaptation disabled)); retina: 95.0980% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 89.8148% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,3.7,0.1,0.2,"liver: 3.7 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000167195,GOLGA6C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.029798,0.0197959,-0.266119
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 72.3881% (minimum 97%, Supported); retina: 95.0980% (minimum 99%, Missing); skeletal muscle: 89.8148% (minimum 97%, Supported)",0,1,partial,3.7,0.1,0.2,"liver: 3.7 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000167195,GOLGA6C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0197959,-0.246119
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.7,0.2,2.2,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; spleen; thymus,ENSG00000167210,LOXHD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.0204% (minimum 95%, Baseline (adaptation disabled)); basal ganglia: 93.3054% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.8446% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2379% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.6726% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.5368% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.8966% (minimum 99%, Baseline (adaptation disabled)); lung: 96.1207% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.5311% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.9565% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,6.7,0.2,2.2,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; spleen; thymus,ENSG00000167210,LOXHD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0397959,0.0211111,-0.221034
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.0204% (minimum 95%, Missing); basal ganglia: 93.3054% (minimum 99%, Missing); bone marrow: 88.8446% (minimum 99%, Missing); cerebral cortex: 98.2379% (minimum 99%, Missing); choroid plexus: 98.6726% (minimum 99%, Missing); heart muscle: 96.5368% (minimum 99%, Missing); kidney: 76.8966% (minimum 99%, Missing); lung: 96.1207% (minimum 99%, Missing); pituitary gland: 92.5311% (minimum 99%, Missing); skeletal muscle: 96.9565% (minimum 99%, Missing)",0,80,unavailable,6.7,0.2,2.2,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; spleen; thymus,ENSG00000167210,LOXHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0397959,0.0211111,-0.221034
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,13,10,2.7,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,ENSG00000167311,ART5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.9619% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.0828% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.3894% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9619% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.2789% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2789% (minimum 99%, Baseline (adaptation disabled)); lung: 97.2789% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.9619% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.0828% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.6109% (minimum 99%, Baseline (adaptation disabled)); retina: 97.9452% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0166% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.7500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.6216% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 91.3738% (minimum 95%, Baseline (adaptation disabled)); tongue: 74.0933% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,13,10,2.7,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,ENSG00000167311,ART5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.036262,-0.229067,-0.3025
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.9619% (minimum 99%, Missing); choroid plexus: 91.0828% (minimum 99%, Missing); heart muscle: 94.3894% (minimum 99%, Missing); hypothalamus: 98.9619% (minimum 99%, Missing); kidney: 97.2789% (minimum 99%, Missing); liver: 97.2789% (minimum 99%, Missing); lung: 97.2789% (minimum 99%, Missing); pancreas: 98.9619% (minimum 99%, Missing); parathyroid gland: 91.0828% (minimum 97%, Missing); pituitary gland: 97.6109% (minimum 99%, Missing); retina: 97.9452% (minimum 99%, Missing); salivary gland: 95.0166% (minimum 97%, Missing); skeletal muscle: 68.7500% (minimum 99%, Missing); smooth muscle: 96.6216% (minimum 99%, Missing); thyroid gland: 91.3738% (minimum 95%, Missing); tongue: 74.0933% (minimum 97%, Missing)",0,80,unavailable,13,10,2.7,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,ENSG00000167311,ART5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.036262,-0.229067,-0.3025
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000167360,OR51Q1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000167360,OR51Q1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000167360,OR51Q1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,15.4,6.9,7.2,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); tongue: 6.9 nTPM (protected, limit 2); skeletal muscle: 6.6 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); hypothalamus: 6 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); amygdala: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); rectum: 5.4 nTPM (protected, limit 2); adipose tissue: 5.3 nTPM (manageable, limit 5); lung: 5.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 2); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); adrenal gland: 4.1 nTPM (vital, limit 1); urinary bladder: 4.1 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); stomach: 4 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167377,ZNF23,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.2308% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.2542% (minimum 99%, Baseline (adaptation disabled)); amygdala: 58.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 57.8947% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.1667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 42.3077% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 54.6099% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 33.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 58.7786% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.6415% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.8120% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.6299% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.3957% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 56.2044% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 59.6899% (minimum 99%, Baseline (adaptation disabled)); lung: 59.6899% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.2044% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.1111% (minimum 99%, Baseline (adaptation disabled)); pancreas: 63.6364% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.6299% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 35.6481% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.7786% (minimum 97%, Baseline (adaptation disabled)); retina: 33.4783% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.7059% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 53.8462% (minimum 99%, Baseline (adaptation disabled)); skin: 58.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.1111% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.8462% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.0370% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.8947% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.8120% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.6016% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 51.6779% (minimum 95%, Baseline (adaptation disabled)); tongue: 52.7397% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.2542% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,15.4,6.9,7.2,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); tongue: 6.9 nTPM (protected, limit 2); skeletal muscle: 6.6 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); hypothalamus: 6 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); amygdala: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); rectum: 5.4 nTPM (protected, limit 2); adipose tissue: 5.3 nTPM (manageable, limit 5); lung: 5.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 2); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); adrenal gland: 4.1 nTPM (vital, limit 1); urinary bladder: 4.1 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); stomach: 4 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167377,ZNF23,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.433221,-0.442603,-0.656667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.2308% (minimum 95%, Missing); adrenal gland: 65.2542% (minimum 99%, Missing); amygdala: 58.3333% (minimum 99%, Missing); basal ganglia: 57.8947% (minimum 99%, Missing); bone marrow: 64.1667% (minimum 99%, Missing); cerebellum: 42.3077% (minimum 99%, Missing); cerebral cortex: 54.6099% (minimum 99%, Missing); choroid plexus: 33.3333% (minimum 99%, Missing); colon: 58.7786% (minimum 97%, Missing); duodenum: 72.6415% (minimum 99%, Missing); esophagus: 65.8120% (minimum 97%, Missing); heart muscle: 60.6299% (minimum 99%, Missing); hippocampal formation: 55.3957% (minimum 99%, Missing); hypothalamus: 56.2044% (minimum 99%, Missing); kidney: 58.3333% (minimum 99%, Missing); liver: 59.6899% (minimum 99%, Missing); lung: 59.6899% (minimum 99%, Missing); lymph node: 56.2044% (minimum 97%, Missing); midbrain: 61.1111% (minimum 99%, Missing); pancreas: 63.6364% (minimum 99%, Missing); parathyroid gland: 60.6299% (minimum 97%, Missing); pituitary gland: 35.6481% (minimum 99%, Missing); rectum: 58.7786% (minimum 97%, Missing); retina: 33.4783% (minimum 99%, Missing); salivary gland: 64.7059% (minimum 97%, Missing); skeletal muscle: 53.8462% (minimum 99%, Missing); skin: 58.3333% (minimum 95%, Missing); small intestine: 61.1111% (minimum 99%, Missing); smooth muscle: 53.8462% (minimum 99%, Missing); spinal cord: 57.0370% (minimum 99%, Missing); spleen: 57.8947% (minimum 95%, Missing); stomach: 65.8120% (minimum 97%, Missing); thymus: 62.6016% (minimum 95%, Missing); thyroid gland: 51.6779% (minimum 95%, Missing); tongue: 52.7397% (minimum 97%, Missing); urinary bladder: 65.2542% (minimum 97%, Missing)",0,80,unavailable,15.4,6.9,7.2,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); tongue: 6.9 nTPM (protected, limit 2); skeletal muscle: 6.6 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); hypothalamus: 6 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); amygdala: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); rectum: 5.4 nTPM (protected, limit 2); adipose tissue: 5.3 nTPM (manageable, limit 5); lung: 5.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 2); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); adrenal gland: 4.1 nTPM (vital, limit 1); urinary bladder: 4.1 nTPM (protected, limit 2); esophagus: 4 nTPM (protected, limit 2); stomach: 4 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167377,ZNF23,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.433221,-0.442603,-0.656667
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,7.8,6.2,7.1,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000167394,ZNF668,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4803% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 53.2847% (minimum 99%, Baseline (adaptation disabled)); amygdala: 55.7252% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.4776% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.3444% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 50.3448% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.3448% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.6596% (minimum 99%, Baseline (adaptation disabled)); colon: 57.4803% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.9310% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.0741% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.0312% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 53.2847% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 57.4803% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.9310% (minimum 99%, Baseline (adaptation disabled)); liver: 60.8333% (minimum 99%, Baseline (adaptation disabled)); lung: 62.9310% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.7374% (minimum 97%, Baseline (adaptation disabled)); midbrain: 59.8361% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.7658% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 76.8421% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 60.3306% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.8837% (minimum 97%, Baseline (adaptation disabled)); retina: 90.1235% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.8644% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.3030% (minimum 99%, Baseline (adaptation disabled)); skin: 50.6944% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.8333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.8679% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.3496% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.7252% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.3445% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.5686% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.6018% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.0225% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.8872% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,7.8,6.2,7.1,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000167394,ZNF668,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.443056,-0.429259,-0.506556
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4803% (minimum 95%, Missing); adrenal gland: 53.2847% (minimum 99%, Missing); amygdala: 55.7252% (minimum 99%, Missing); basal ganglia: 54.4776% (minimum 99%, Missing); bone marrow: 48.3444% (minimum 99%, Missing); cerebellum: 50.3448% (minimum 99%, Missing); cerebral cortex: 50.3448% (minimum 99%, Missing); choroid plexus: 77.6596% (minimum 99%, Missing); colon: 57.4803% (minimum 97%, Missing); duodenum: 62.9310% (minimum 99%, Missing); esophagus: 54.0741% (minimum 97%, Missing); heart muscle: 57.0312% (minimum 99%, Missing); hippocampal formation: 53.2847% (minimum 99%, Missing); hypothalamus: 57.4803% (minimum 99%, Missing); kidney: 62.9310% (minimum 99%, Missing); liver: 60.8333% (minimum 99%, Missing); lung: 62.9310% (minimum 99%, Missing); lymph node: 73.7374% (minimum 97%, Missing); midbrain: 59.8361% (minimum 99%, Missing); pancreas: 65.7658% (minimum 99%, Missing); parathyroid gland: 76.8421% (minimum 97%, Missing); pituitary gland: 60.3306% (minimum 99%, Missing); rectum: 84.8837% (minimum 97%, Missing); retina: 90.1235% (minimum 99%, Missing); salivary gland: 61.8644% (minimum 97%, Missing); skeletal muscle: 55.3030% (minimum 99%, Missing); skin: 50.6944% (minimum 95%, Missing); small intestine: 60.8333% (minimum 99%, Missing); smooth muscle: 68.8679% (minimum 99%, Missing); spinal cord: 59.3496% (minimum 99%, Missing); spleen: 55.7252% (minimum 95%, Missing); stomach: 61.3445% (minimum 97%, Missing); thymus: 71.5686% (minimum 95%, Missing); thyroid gland: 64.6018% (minimum 95%, Missing); tongue: 82.0225% (minimum 97%, Missing); urinary bladder: 54.8872% (minimum 97%, Missing)",0,2,partial,7.8,6.2,7.1,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 2); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000167394,ZNF668,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.443056,-0.429259,-0.506556
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,9.1,7,8.3,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 2); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 2); adipose tissue: 5.4 nTPM (manageable, limit 5); stomach: 5.4 nTPM (protected, limit 2); pancreas: 5.4 nTPM (vital, limit 1); urinary bladder: 5.2 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); colon: 4.9 nTPM (protected, limit 2); pituitary gland: 4.9 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); liver: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167395,ZNF646,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.2368% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.2069% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.4126% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.8056% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.3138% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.3651% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.7458% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.1538% (minimum 99%, Baseline (adaptation disabled)); colon: 83.6120% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.1282% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.4595% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.2069% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.3392% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.1751% (minimum 99%, Baseline (adaptation disabled)); liver: 85.6164% (minimum 99%, Baseline (adaptation disabled)); lung: 84.7458% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.1250% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.0282% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.2368% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.3242% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.6120% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.2527% (minimum 97%, Baseline (adaptation disabled)); retina: 93.9850% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.6452% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.6871% (minimum 99%, Baseline (adaptation disabled)); skin: 76.2195% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.8722% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.9680% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.5052% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.2195% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.2368% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.0751% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 83.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.7193% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.7815% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,9.1,7,8.3,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 2); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 2); adipose tissue: 5.4 nTPM (manageable, limit 5); stomach: 5.4 nTPM (protected, limit 2); pancreas: 5.4 nTPM (vital, limit 1); urinary bladder: 5.2 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); colon: 4.9 nTPM (protected, limit 2); pituitary gland: 4.9 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); liver: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167395,ZNF646,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.199249,-0.18875,-0.256862
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.2368% (minimum 95%, Uncertain); adrenal gland: 86.2069% (minimum 99%, Missing); amygdala: 87.4126% (minimum 99%, Missing); basal ganglia: 86.8056% (minimum 99%, Missing); bone marrow: 73.3138% (minimum 99%, Uncertain); cerebellum: 79.3651% (minimum 99%, Uncertain); cerebral cortex: 84.7458% (minimum 99%, Missing); choroid plexus: 96.1538% (minimum 99%, Missing); colon: 83.6120% (minimum 97%, Missing); duodenum: 80.1282% (minimum 99%, Uncertain); esophagus: 83.3333% (minimum 97%, Uncertain); heart muscle: 84.4595% (minimum 99%, Uncertain); hippocampal formation: 86.2069% (minimum 99%, Missing); hypothalamus: 88.3392% (minimum 99%, Missing); kidney: 84.1751% (minimum 99%, Missing); liver: 85.6164% (minimum 99%, Missing); lung: 84.7458% (minimum 99%, Uncertain); lymph node: 78.1250% (minimum 97%, Uncertain); midbrain: 88.0282% (minimum 99%, Missing); pancreas: 82.2368% (minimum 99%, Uncertain); parathyroid gland: 85.3242% (minimum 97%, Uncertain); pituitary gland: 83.6120% (minimum 99%, Missing); rectum: 90.2527% (minimum 97%, Uncertain); retina: 93.9850% (minimum 99%, Missing); salivary gland: 80.6452% (minimum 97%, Uncertain); skeletal muscle: 76.6871% (minimum 99%, Uncertain); skin: 76.2195% (minimum 95%, Uncertain); small intestine: 79.8722% (minimum 99%, Uncertain); smooth muscle: 88.9680% (minimum 99%, Uncertain); spinal cord: 86.5052% (minimum 99%, Missing); spleen: 76.2195% (minimum 95%, Uncertain); stomach: 82.2368% (minimum 97%, Uncertain); thymus: 75.0751% (minimum 95%, Missing); thyroid gland: 83.3333% (minimum 95%, Uncertain); tongue: 87.7193% (minimum 97%, Missing); urinary bladder: 82.7815% (minimum 97%, Uncertain)",0,2,partial,9.1,7,8.3,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 2); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 2); adipose tissue: 5.4 nTPM (manageable, limit 5); stomach: 5.4 nTPM (protected, limit 2); pancreas: 5.4 nTPM (vital, limit 1); urinary bladder: 5.2 nTPM (protected, limit 2); esophagus: 5 nTPM (protected, limit 2); colon: 4.9 nTPM (protected, limit 2); pituitary gland: 4.9 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); liver: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167395,ZNF646,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.199249,-0.18875,-0.256862
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,443.7,97.3,96.2,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 2); adipose tissue: 96.2 nTPM (manageable, limit 10); heart muscle: 95.8 nTPM (vital, limit 2); colon: 93.8 nTPM (protected, limit 2); salivary gland: 89.7 nTPM (protected, limit 2); stomach: 85.4 nTPM (protected, limit 2); smooth muscle: 81.6 nTPM (vital, limit 2); small intestine: 79.9 nTPM (vital, limit 1); skin: 78.6 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (manageable, limit 5); spleen: 60.7 nTPM (manageable, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 2); parathyroid gland: 49.5 nTPM (protected, limit 2); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 4); lymph node: 35 nTPM (protected, limit 2); thymus: 34 nTPM (manageable, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 2); tongue: 31.1 nTPM (protected, limit 2); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000167397,VKORC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6609% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 51.6698% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.0569% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.5117% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 67.1894% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.8105% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.4344% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 42.3574% (minimum 99%, Baseline (adaptation disabled)); colon: 54.2885% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.1970% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.8504% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 53.7645% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.3727% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.1070% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.2878% (minimum 99%, Baseline (adaptation disabled)); liver: 20.0685% (minimum 99%, Baseline (adaptation disabled)); lung: 59.7639% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.0929% (minimum 97%, Baseline (adaptation disabled)); midbrain: 67.7204% (minimum 99%, Baseline (adaptation disabled)); pancreas: 40.6421% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.2356% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 49.7321% (minimum 99%, Baseline (adaptation disabled)); rectum: 73.7260% (minimum 97%, Baseline (adaptation disabled)); retina: 83.3832% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.3953% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.0401% (minimum 99%, Baseline (adaptation disabled)); skin: 58.6316% (minimum 95%, Baseline (adaptation disabled)); small intestine: 58.2331% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.7202% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.5680% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.7298% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.6057% (minimum 97%, Baseline (adaptation disabled)); thymus: 76.6162% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.0863% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.1754% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.3781% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,443.7,97.3,96.2,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 2); adipose tissue: 96.2 nTPM (manageable, limit 5); heart muscle: 95.8 nTPM (vital, limit 1); colon: 93.8 nTPM (protected, limit 2); salivary gland: 89.7 nTPM (protected, limit 2); stomach: 85.4 nTPM (protected, limit 2); smooth muscle: 81.6 nTPM (vital, limit 1); small intestine: 79.9 nTPM (vital, limit 1); skin: 78.6 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (manageable, limit 5); spleen: 60.7 nTPM (manageable, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 2); parathyroid gland: 49.5 nTPM (protected, limit 2); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 2); lymph node: 35 nTPM (protected, limit 2); thymus: 34 nTPM (manageable, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 2); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000167397,VKORC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.413391,-0.436219,-0.789315
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6609% (minimum 90%, Approved); adrenal gland: 51.6698% (minimum 99%, Missing); amygdala: 72.0569% (minimum 99%, Missing); basal ganglia: 68.5117% (minimum 99%, Missing); bone marrow: 67.1894% (minimum 99%, Missing); cerebellum: 72.8105% (minimum 99%, Missing); cerebral cortex: 73.4344% (minimum 99%, Missing); choroid plexus: 42.3574% (minimum 99%, Missing); colon: 54.2885% (minimum 97%, Missing); duodenum: 72.1970% (minimum 99%, Missing); esophagus: 68.8504% (minimum 97%, Missing); heart muscle: 53.7645% (minimum 98%, Approved); hippocampal formation: 70.3727% (minimum 99%, Missing); hypothalamus: 70.1070% (minimum 99%, Missing); kidney: 48.2878% (minimum 99%, Missing); liver: 20.0685% (minimum 99%, Missing); lung: 59.7639% (minimum 99%, Missing); lymph node: 76.0929% (minimum 97%, Missing); midbrain: 67.7204% (minimum 99%, Missing); pancreas: 40.6421% (minimum 99%, Missing); parathyroid gland: 69.2356% (minimum 97%, Missing); pituitary gland: 49.7321% (minimum 99%, Missing); rectum: 73.7260% (minimum 95%, Approved); retina: 83.3832% (minimum 99%, Missing); salivary gland: 55.3953% (minimum 97%, Missing); skeletal muscle: 77.0401% (minimum 98%, Approved); skin: 58.6316% (minimum 95%, Missing); small intestine: 58.2331% (minimum 99%, Missing); smooth muscle: 57.7202% (minimum 98%, Approved); spinal cord: 65.5680% (minimum 99%, Missing); spleen: 64.7298% (minimum 95%, Missing); stomach: 56.6057% (minimum 97%, Missing); thymus: 76.6162% (minimum 95%, Missing); thyroid gland: 60.0863% (minimum 95%, Missing); tongue: 78.1754% (minimum 97%, Missing); urinary bladder: 53.3781% (minimum 97%, Missing)",0,4,partial,443.7,97.3,96.2,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 2); adipose tissue: 96.2 nTPM (manageable, limit 10); heart muscle: 95.8 nTPM (vital, limit 2); colon: 93.8 nTPM (protected, limit 2); salivary gland: 89.7 nTPM (protected, limit 2); stomach: 85.4 nTPM (protected, limit 2); smooth muscle: 81.6 nTPM (vital, limit 2); small intestine: 79.9 nTPM (vital, limit 1); skin: 78.6 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (manageable, limit 5); spleen: 60.7 nTPM (manageable, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 2); parathyroid gland: 49.5 nTPM (protected, limit 2); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 4); lymph node: 35 nTPM (protected, limit 2); thymus: 34 nTPM (manageable, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 2); tongue: 31.1 nTPM (protected, limit 2); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000167397,VKORC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.363684,-0.436219,-0.789315
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,13,partial,13.3,5.1,8.1,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 6); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 6); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); duodenum: 4.8 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167523,SPATA33,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.5157% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.3446% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.8983% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.0228% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.2709% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.4875% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.2828% (minimum 99%, Baseline (adaptation disabled)); colon: 95.6822% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.8478% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.5997% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.6841% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.0311% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.2565% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.5969% (minimum 99%, Baseline (adaptation disabled)); liver: 94.7819% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0257% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.1073% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.6822% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.9379% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.1031% (minimum 99%, Baseline (adaptation disabled)); retina: 94.4587% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.4317% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.3141% (minimum 99%, Baseline (adaptation disabled)); small intestine: 92.5647% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.9664% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.5997% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.7649% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.1876% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.3478% (minimum 97%, Baseline (adaptation disabled))",0,13,partial,13.3,5.1,8.1,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); esophagus: 5.1 nTPM (protected, limit 2); spinal cord: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); stomach: 4.9 nTPM (protected, limit 2); duodenum: 4.8 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 2); salivary gland: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); lymph node: 2.4 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167523,SPATA33,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,-0.0181245,-0.0140035,-0.0971716
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.3446% (minimum 99%, Missing); basal ganglia: 93.8983% (minimum 99%, Missing); cerebral cortex: 92.4875% (minimum 95%, Enhanced); choroid plexus: 89.2828% (minimum 99%, Missing); colon: 95.6822% (minimum 97%, Missing); duodenum: 95.8478% (minimum 99%, Missing); hippocampal formation: 93.0311% (minimum 99%, Missing); hypothalamus: 92.2565% (minimum 99%, Missing); kidney: 90.5969% (minimum 99%, Missing); liver: 94.7819% (minimum 95%, Enhanced); midbrain: 95.1073% (minimum 99%, Missing); pituitary gland: 92.1031% (minimum 99%, Missing); retina: 94.4587% (minimum 99%, Missing); small intestine: 92.5647% (minimum 99%, Missing); spinal cord: 95.5997% (minimum 99%, Missing); stomach: 95.7649% (minimum 97%, Missing)",0,13,partial,13.3,5.1,8.1,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 6); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 6); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); duodenum: 4.8 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167523,SPATA33,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,0.0202277,-0.0131779,-0.0971716
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,8,2.2,9.6,"kidney: 8 nTPM (vital, limit 2); cerebellum: 7.2 nTPM (vital, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); midbrain: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 2); retina: 1.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167525,PROCA1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7337% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.1284% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.9933% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.4026% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.2927% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.7407% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.7337% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2379% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.5679% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5151% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.5679% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.3466% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.8446% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.7891% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.7282% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,8,2.2,9.6,"spleen: 9.6 nTPM (manageable, limit 5); kidney: 8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); lymph node: 2.2 nTPM (protected, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167525,PROCA1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00271829,0.017407,-0.0343213
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.7337% (minimum 99%, Missing); basal ganglia: 97.1284% (minimum 99%, Missing); cerebellum: 95.9933% (minimum 98%, Approved); cerebral cortex: 97.4026% (minimum 98%, Approved); choroid plexus: 97.2927% (minimum 99%, Missing); hippocampal formation: 97.7337% (minimum 99%, Missing); hypothalamus: 97.2379% (minimum 99%, Missing); kidney: 95.5679% (minimum 98%, Approved); midbrain: 97.5679% (minimum 99%, Missing); pituitary gland: 98.3466% (minimum 99%, Missing); small intestine: 97.8446% (minimum 98%, Approved); spinal cord: 97.7891% (minimum 99%, Missing)",0,4,partial,8,2.2,9.6,"kidney: 8 nTPM (vital, limit 2); cerebellum: 7.2 nTPM (vital, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); midbrain: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 2); retina: 1.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167525,PROCA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0419494,0.0271098,-0.0243213
True,compatible,,True,True,False,,0,4,partial,0,0.1,0,,,52,not_established,not_triggered,,,ENSG00000167531,LALBA,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0.1,0,,,52,not_established,not_triggered,,,ENSG00000167531,LALBA,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.0299526,0.01
True,compatible,,True,True,True,,0,4,partial,0,0.1,0,,,52,not_established,not_triggered,,,ENSG00000167531,LALBA,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,6,3.9,4.5,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000167554,ZNF610,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.6977% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.2500% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.3415% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.6897% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.9740% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.4706% (minimum 99%, Baseline (adaptation disabled)); colon: 87.9699% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.3548% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.4062% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.3944% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.0506% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.1250% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.4834% (minimum 99%, Baseline (adaptation disabled)); liver: 96.6942% (minimum 99%, Baseline (adaptation disabled)); lung: 86.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.6364% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.1250% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.3130% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.9787% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.3130% (minimum 97%, Baseline (adaptation disabled)); retina: 66.1017% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.4062% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.4062% (minimum 99%, Baseline (adaptation disabled)); skin: 94.3548% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.8571% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.9787% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.4819% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.5714% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.6364% (minimum 97%, Baseline (adaptation disabled)); thymus: 79.5918% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 72.2222% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.6364% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.3134% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,6,3.9,4.5,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000167554,ZNF610,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.227778,-0.22,-0.328983
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 81.2500% (minimum 95%, Enhanced); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 71.3415% (minimum 99%, Missing); bone marrow: 97.5000% (minimum 99%, Missing); cerebellum: 80.6897% (minimum 99%, Missing); cerebral cortex: 75.9740% (minimum 99%, Missing); choroid plexus: 76.4706% (minimum 99%, Missing); colon: 87.9699% (minimum 97%, Missing); duodenum: 94.3548% (minimum 99%, Missing); esophagus: 91.4062% (minimum 97%, Missing); heart muscle: 82.3944% (minimum 99%, Missing); hippocampal formation: 74.0506% (minimum 99%, Missing); hypothalamus: 73.1250% (minimum 99%, Missing); kidney: 77.4834% (minimum 99%, Missing); lung: 86.6667% (minimum 99%, Missing); lymph node: 88.6364% (minimum 97%, Missing); midbrain: 73.1250% (minimum 99%, Missing); pancreas: 89.3130% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 80%, Enhanced); pituitary gland: 82.9787% (minimum 99%, Missing); rectum: 89.3130% (minimum 97%, Missing); retina: 66.1017% (minimum 99%, Missing); salivary gland: 91.4062% (minimum 97%, Missing); skeletal muscle: 91.4062% (minimum 99%, Missing); skin: 94.3548% (minimum 95%, Missing); small intestine: 92.8571% (minimum 99%, Missing); smooth muscle: 82.9787% (minimum 99%, Missing); spinal cord: 70.4819% (minimum 99%, Missing); stomach: 88.6364% (minimum 97%, Missing); thymus: 79.5918% (minimum 95%, Missing); thyroid gland: 72.2222% (minimum 95%, Missing); tongue: 88.6364% (minimum 97%, Missing); urinary bladder: 87.3134% (minimum 97%, Missing)",0,2,partial,6,3.9,4.5,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000167554,ZNF610,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.227778,-0.0968657,-0.328983
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.3,5.6,7.2,"thymus: 7.2 nTPM (manageable, limit 5); thyroid gland: 5.7 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); bone marrow: 5.3 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); lung: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167562,ZNF701,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.0455% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.2381% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.9444% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.8219% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.6786% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.6410% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.7297% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.6234% (minimum 99%, Baseline (adaptation disabled)); colon: 60.8247% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.8352% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.6047% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.6047% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.9444% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.9444% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.7660% (minimum 99%, Baseline (adaptation disabled)); liver: 83.0986% (minimum 99%, Baseline (adaptation disabled)); lung: 61.4583% (minimum 99%, Baseline (adaptation disabled)); lymph node: 51.3043% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.8219% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.8161% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.4583% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.8395% (minimum 99%, Baseline (adaptation disabled)); rectum: 55.6604% (minimum 97%, Baseline (adaptation disabled)); retina: 64.1304% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.5556% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 73.7500% (minimum 99%, Baseline (adaptation disabled)); skin: 59.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.2816% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.8352% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.6316% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.6604% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.2816% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.0382% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.8621% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.0455% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.5556% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.3,5.6,7.2,"thymus: 7.2 nTPM (manageable, limit 5); thyroid gland: 5.7 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); bone marrow: 5.3 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); lung: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167562,ZNF701,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.499618,-0.456957,-0.463214
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.0455% (minimum 95%, Missing); adrenal gland: 70.2381% (minimum 99%, Missing); amygdala: 81.9444% (minimum 99%, Missing); basal ganglia: 80.8219% (minimum 99%, Missing); bone marrow: 52.6786% (minimum 99%, Missing); cerebellum: 75.6410% (minimum 99%, Missing); cerebral cortex: 79.7297% (minimum 99%, Missing); choroid plexus: 76.6234% (minimum 99%, Missing); colon: 60.8247% (minimum 97%, Missing); duodenum: 64.8352% (minimum 99%, Missing); esophagus: 68.6047% (minimum 97%, Missing); heart muscle: 68.6047% (minimum 99%, Missing); hippocampal formation: 81.9444% (minimum 99%, Missing); hypothalamus: 81.9444% (minimum 99%, Missing); kidney: 62.7660% (minimum 99%, Missing); liver: 83.0986% (minimum 99%, Missing); lung: 61.4583% (minimum 99%, Missing); lymph node: 51.3043% (minimum 97%, Missing); midbrain: 80.8219% (minimum 99%, Missing); pancreas: 67.8161% (minimum 99%, Missing); parathyroid gland: 61.4583% (minimum 97%, Missing); pituitary gland: 72.8395% (minimum 99%, Missing); rectum: 55.6604% (minimum 97%, Missing); retina: 64.1304% (minimum 99%, Missing); salivary gland: 65.5556% (minimum 97%, Missing); skeletal muscle: 73.7500% (minimum 99%, Missing); skin: 59.0000% (minimum 95%, Missing); small intestine: 57.2816% (minimum 99%, Missing); smooth muscle: 64.8352% (minimum 99%, Missing); spinal cord: 77.6316% (minimum 99%, Missing); spleen: 55.6604% (minimum 95%, Missing); stomach: 57.2816% (minimum 97%, Missing); thymus: 45.0382% (minimum 95%, Missing); thyroid gland: 50.8621% (minimum 95%, Missing); tongue: 67.0455% (minimum 97%, Missing); urinary bladder: 65.5556% (minimum 97%, Missing)",0,80,unavailable,5.3,5.6,7.2,"thymus: 7.2 nTPM (manageable, limit 5); thyroid gland: 5.7 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 2); bone marrow: 5.3 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); lung: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); urinary bladder: 3.1 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167562,ZNF701,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.499618,-0.456957,-0.463214
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,3,partial,17.8,2,0,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),59,not_established,not_triggered,,,ENSG00000167612,ANKRD33,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 20.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 2.7322% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,17.8,2,0,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),59,not_established,not_triggered,,,ENSG00000167612,ANKRD33,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,-0.77,-0.962678
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"liver: 83.3333% (minimum 95%, Enhanced); parathyroid gland: 20.0000% (minimum 80%, Enhanced); retina: 2.7322% (minimum 99%, Missing)",0,3,partial,17.8,2,0,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),59,not_established,not_triggered,,,ENSG00000167612,ANKRD33,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,-0.6,-0.962678
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,32.4,26.5,12.5,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 2); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 2); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); stomach: 12.1 nTPM (protected, limit 2); esophagus: 12 nTPM (protected, limit 2); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 2); thymus: 11 nTPM (manageable, limit 5); spleen: 11 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 2); colon: 10.8 nTPM (protected, limit 2); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); rectum: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167632,TRAPPC9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.7065% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 47.5806% (minimum 99%, Baseline (adaptation disabled)); amygdala: 50.6438% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 46.4567% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 51.7544% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 42.7536% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 38.6885% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 49.3724% (minimum 99%, Baseline (adaptation disabled)); colon: 52.2124% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.2041% (minimum 99%, Baseline (adaptation disabled)); esophagus: 49.5798% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 44.6970% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 50.4274% (minimum 99%, Baseline (adaptation disabled)); kidney: 46.8254% (minimum 99%, Baseline (adaptation disabled)); liver: 51.0823% (minimum 99%, Baseline (adaptation disabled)); lung: 56.1905% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.2041% (minimum 97%, Baseline (adaptation disabled)); midbrain: 47.5806% (minimum 99%, Baseline (adaptation disabled)); pancreas: 50.6438% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 30.8094% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 36.8750% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.0455% (minimum 97%, Baseline (adaptation disabled)); retina: 46.0938% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.0823% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 26.6968% (minimum 99%, Baseline (adaptation disabled)); skin: 51.7544% (minimum 95%, Baseline (adaptation disabled)); small intestine: 52.9148% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.1016% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 46.4567% (minimum 99%, Baseline (adaptation disabled)); spleen: 51.7544% (minimum 95%, Baseline (adaptation disabled)); stomach: 49.3724% (minimum 97%, Baseline (adaptation disabled)); thymus: 51.7544% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.5597% (minimum 95%, Baseline (adaptation disabled)); tongue: 40.9722% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.2124% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,32.4,26.5,12.5,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 2); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 2); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); stomach: 12.1 nTPM (protected, limit 2); esophagus: 12 nTPM (protected, limit 2); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 2); thymus: 11 nTPM (manageable, limit 5); spleen: 11 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 2); colon: 10.8 nTPM (protected, limit 2); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); rectum: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167632,TRAPPC9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.464403,-0.661906,-0.723032
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.7065% (minimum 95%, Missing); adrenal gland: 47.5806% (minimum 99%, Missing); amygdala: 50.6438% (minimum 99%, Missing); basal ganglia: 46.4567% (minimum 99%, Missing); bone marrow: 51.7544% (minimum 99%, Missing); cerebellum: 42.7536% (minimum 99%, Missing); cerebral cortex: 38.6885% (minimum 99%, Missing); choroid plexus: 49.3724% (minimum 99%, Missing); colon: 52.2124% (minimum 97%, Missing); duodenum: 60.2041% (minimum 99%, Missing); esophagus: 49.5798% (minimum 97%, Missing); heart muscle: 44.6970% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 50.4274% (minimum 99%, Missing); kidney: 46.8254% (minimum 99%, Missing); liver: 51.0823% (minimum 99%, Missing); lung: 56.1905% (minimum 99%, Missing); lymph node: 60.2041% (minimum 97%, Missing); midbrain: 47.5806% (minimum 99%, Missing); pancreas: 50.6438% (minimum 99%, Missing); parathyroid gland: 30.8094% (minimum 97%, Missing); pituitary gland: 36.8750% (minimum 99%, Missing); rectum: 67.0455% (minimum 97%, Missing); retina: 46.0938% (minimum 99%, Missing); salivary gland: 51.0823% (minimum 97%, Missing); skeletal muscle: 26.6968% (minimum 99%, Missing); skin: 51.7544% (minimum 95%, Missing); small intestine: 52.9148% (minimum 99%, Missing); smooth muscle: 63.1016% (minimum 99%, Missing); spinal cord: 46.4567% (minimum 99%, Missing); spleen: 51.7544% (minimum 95%, Missing); stomach: 49.3724% (minimum 97%, Missing); thymus: 51.7544% (minimum 95%, Missing); thyroid gland: 48.5597% (minimum 95%, Missing); tongue: 40.9722% (minimum 97%, Missing); urinary bladder: 52.2124% (minimum 97%, Missing)",0,80,unavailable,32.4,26.5,12.5,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 2); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 2); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); stomach: 12.1 nTPM (protected, limit 2); esophagus: 12 nTPM (protected, limit 2); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 2); thymus: 11 nTPM (manageable, limit 5); spleen: 11 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 2); colon: 10.8 nTPM (protected, limit 2); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); rectum: 5.8 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167632,TRAPPC9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.464403,-0.661906,-0.723032
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000167634,NLRP7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 95.0000% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.4359% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.3636% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000167634,NLRP7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.0863636,0.00435897,-0.04
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 95.0000% (minimum 99%, Missing); small intestine: 97.4359% (minimum 99%, Missing); spleen: 86.3636% (minimum 95%, Missing)",0,80,unavailable,0.2,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000167634,NLRP7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.0863636,0.00435897,-0.04
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,7.1,0,0.8,"retina: 7.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000167791,CABP2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,7.1,0,0.8,"retina: 7.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000167791,CABP2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,7.1,0,0.8,"retina: 7.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000167791,CABP2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,2.3,2.1,1.9,"lung: 2.3 nTPM (vital, limit 2); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167981,ZNF597,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.8571% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.8511% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 67.8571% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.5098% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.4068% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.1667% (minimum 99%, Baseline (adaptation disabled)); colon: 77.5510% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.5510% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.5510% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.8511% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.5510% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.5098% (minimum 99%, Baseline (adaptation disabled)); liver: 69.0909% (minimum 99%, Baseline (adaptation disabled)); lung: 62.2951% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.4068% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.8511% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.6981% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 74.5098% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 74.5098% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.8511% (minimum 97%, Baseline (adaptation disabled)); retina: 62.2951% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.1667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.4444% (minimum 99%, Baseline (adaptation disabled)); skin: 74.5098% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.5098% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.1667% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.8571% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.6981% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.1667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.6981% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,2.3,2.1,1.9,"lung: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); adrenal gland: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167981,ZNF597,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.283333,-0.325932,-0.367049
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 70.3704% (minimum 90%, Approved); adrenal gland: 67.8571% (minimum 98%, Approved); amygdala: 80.8511% (minimum 99%, Missing); basal ganglia: 76.0000% (minimum 99%, Missing); bone marrow: 67.8571% (minimum 98%, Approved); cerebellum: 74.5098% (minimum 98%, Approved); cerebral cortex: 64.4068% (minimum 99%, Missing); choroid plexus: 79.1667% (minimum 99%, Missing); colon: 77.5510% (minimum 97%, Missing); duodenum: 77.5510% (minimum 98%, Approved); esophagus: 77.5510% (minimum 95%, Approved); heart muscle: 76.0000% (minimum 98%, Approved); hippocampal formation: 80.8511% (minimum 99%, Missing); hypothalamus: 77.5510% (minimum 99%, Missing); kidney: 74.5098% (minimum 99%, Missing); liver: 69.0909% (minimum 98%, Approved); lung: 62.2951% (minimum 98%, Approved); lymph node: 64.4068% (minimum 95%, Approved); midbrain: 80.8511% (minimum 99%, Missing); pancreas: 71.6981% (minimum 98%, Approved); parathyroid gland: 74.5098% (minimum 95%, Approved); pituitary gland: 74.5098% (minimum 99%, Missing); rectum: 80.8511% (minimum 95%, Approved); retina: 62.2951% (minimum 99%, Missing); salivary gland: 79.1667% (minimum 95%, Approved); skeletal muscle: 84.4444% (minimum 98%, Approved); skin: 74.5098% (minimum 90%, Approved); small intestine: 74.5098% (minimum 98%, Approved); smooth muscle: 76.0000% (minimum 98%, Approved); spinal cord: 79.1667% (minimum 99%, Missing); spleen: 67.8571% (minimum 90%, Approved); stomach: 76.0000% (minimum 95%, Approved); thymus: 71.6981% (minimum 95%, Missing); thyroid gland: 66.6667% (minimum 90%, Approved); tongue: 79.1667% (minimum 97%, Missing); urinary bladder: 71.6981% (minimum 95%, Approved)",0,5,partial,2.3,2.1,1.9,"lung: 2.3 nTPM (vital, limit 2); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000167981,ZNF597,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.233333,-0.305932,-0.367049
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,45.3,43.1,37,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 2); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 2); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); thymus: 37 nTPM (manageable, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); spleen: 33.9 nTPM (manageable, limit 5); parathyroid gland: 31.8 nTPM (protected, limit 2); urinary bladder: 31.6 nTPM (protected, limit 2); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 2); esophagus: 28 nTPM (protected, limit 2); thyroid gland: 27.8 nTPM (manageable, limit 5); stomach: 26.8 nTPM (protected, limit 2); adipose tissue: 26.6 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); colon: 26.3 nTPM (protected, limit 2); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); salivary gland: 25.5 nTPM (protected, limit 2); skin: 25.5 nTPM (manageable, limit 5); midbrain: 25.2 nTPM (vital, limit 1); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000167985,SDHAF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1056% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 48.6409% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.3368% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.7613% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 42.9836% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.2192% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 47.6190% (minimum 99%, Baseline (adaptation disabled)); colon: 56.3847% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.6207% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.8387% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 46.5116% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 62.8466% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.8827% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.9209% (minimum 99%, Baseline (adaptation disabled)); liver: 42.8752% (minimum 99%, Baseline (adaptation disabled)); lung: 59.6491% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.6392% (minimum 97%, Baseline (adaptation disabled)); midbrain: 57.4324% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.4406% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.6717% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 46.0081% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.6624% (minimum 97%, Baseline (adaptation disabled)); retina: 59.9647% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.1429% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 47.4860% (minimum 99%, Baseline (adaptation disabled)); skin: 57.1429% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.3847% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.7613% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.7060% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0736% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.9211% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.8873% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.0162% (minimum 95%, Baseline (adaptation disabled)); tongue: 44.0986% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.8293% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,45.3,43.1,37,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 2); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 2); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); thymus: 37 nTPM (manageable, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); spleen: 33.9 nTPM (manageable, limit 5); parathyroid gland: 31.8 nTPM (protected, limit 2); urinary bladder: 31.6 nTPM (protected, limit 2); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 2); esophagus: 28 nTPM (protected, limit 2); thyroid gland: 27.8 nTPM (manageable, limit 5); stomach: 26.8 nTPM (protected, limit 2); adipose tissue: 26.6 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); colon: 26.3 nTPM (protected, limit 2); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); salivary gland: 25.5 nTPM (protected, limit 2); skin: 25.5 nTPM (manageable, limit 5); midbrain: 25.2 nTPM (vital, limit 1); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000167985,SDHAF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.471127,-0.529014,-0.561248
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1056% (minimum 95%, Missing); adrenal gland: 48.6409% (minimum 99%, Missing); amygdala: 59.3368% (minimum 99%, Missing); basal ganglia: 56.7613% (minimum 99%, Missing); bone marrow: 42.9836% (minimum 99%, Missing); cerebellum: 68.0000% (minimum 99%, Missing); cerebral cortex: 58.2192% (minimum 99%, Missing); choroid plexus: 47.6190% (minimum 99%, Missing); colon: 56.3847% (minimum 97%, Missing); duodenum: 58.6207% (minimum 99%, Missing); esophagus: 54.8387% (minimum 97%, Missing); heart muscle: 46.5116% (minimum 99%, Missing); hippocampal formation: 62.8466% (minimum 99%, Missing); hypothalamus: 53.8827% (minimum 99%, Missing); kidney: 48.9209% (minimum 99%, Missing); liver: 42.8752% (minimum 99%, Missing); lung: 59.6491% (minimum 99%, Missing); lymph node: 46.6392% (minimum 97%, Missing); midbrain: 57.4324% (minimum 99%, Missing); pancreas: 59.4406% (minimum 99%, Missing); parathyroid gland: 51.6717% (minimum 97%, Missing); pituitary gland: 46.0081% (minimum 99%, Missing); rectum: 54.6624% (minimum 97%, Missing); retina: 59.9647% (minimum 99%, Missing); salivary gland: 57.1429% (minimum 97%, Missing); skeletal muscle: 47.4860% (minimum 99%, Missing); skin: 57.1429% (minimum 95%, Missing); small intestine: 56.3847% (minimum 99%, Missing); smooth muscle: 56.7613% (minimum 99%, Missing); spinal cord: 61.7060% (minimum 99%, Missing); spleen: 50.0736% (minimum 95%, Missing); stomach: 55.9211% (minimum 97%, Missing); thymus: 47.8873% (minimum 95%, Missing); thyroid gland: 55.0162% (minimum 95%, Missing); tongue: 44.0986% (minimum 97%, Missing); urinary bladder: 51.8293% (minimum 97%, Missing)",0,4,partial,45.3,43.1,37,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 2); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 2); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); thymus: 37 nTPM (manageable, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); spleen: 33.9 nTPM (manageable, limit 5); parathyroid gland: 31.8 nTPM (protected, limit 2); urinary bladder: 31.6 nTPM (protected, limit 2); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 2); esophagus: 28 nTPM (protected, limit 2); thyroid gland: 27.8 nTPM (manageable, limit 5); stomach: 26.8 nTPM (protected, limit 2); adipose tissue: 26.6 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); colon: 26.3 nTPM (protected, limit 2); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); salivary gland: 25.5 nTPM (protected, limit 2); skin: 25.5 nTPM (manageable, limit 5); midbrain: 25.2 nTPM (vital, limit 1); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000167985,SDHAF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.471127,-0.529014,-0.561248
True,compatible,,True,True,False,,0,3,partial,1.2,0.8,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168026,TTC21A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.8938% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.6755% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0263% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.3856% (minimum 99%, Baseline (adaptation disabled)); retina: 98.0263% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.2,0.8,0.6,"pancreas: 1.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168026,TTC21A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.036755,0.0124176,-0.0161438
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.6755% (minimum 99%, Missing); retina: 98.0263% (minimum 99%, Missing)",0,3,partial,1.2,0.8,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168026,TTC21A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0389381,0.0233333,-0.00973684
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,8.4,7.7,4.7,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168038,ULK4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.7233% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.3268% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.9791% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.9791% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.9904% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.4249% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.7806% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.4310% (minimum 99%, Baseline (adaptation disabled)); colon: 93.4156% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.3782% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.8017% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 73.2258% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.5833% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.1909% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.9848% (minimum 99%, Baseline (adaptation disabled)); liver: 91.9028% (minimum 99%, Baseline (adaptation disabled)); lung: 86.9732% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.3268% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.3782% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.2764% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 74.6711% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 89.0196% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.4156% (minimum 97%, Baseline (adaptation disabled)); retina: 79.6491% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.4156% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.2684% (minimum 99%, Baseline (adaptation disabled)); skin: 91.5323% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.2764% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.9732% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.5833% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.9028% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.8000% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.6719% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.8467% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.6531% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,8.4,7.7,4.7,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168038,ULK4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.121533,-0.223289,-0.260096
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.7233% (minimum 95%, Missing); adrenal gland: 88.3268% (minimum 99%, Missing); amygdala: 94.9791% (minimum 99%, Missing); basal ganglia: 94.9791% (minimum 99%, Missing); bone marrow: 72.9904% (minimum 99%, Missing); cerebellum: 97.4249% (minimum 99%, Missing); cerebral cortex: 95.7806% (minimum 99%, Missing); choroid plexus: 76.4310% (minimum 99%, Missing); colon: 93.4156% (minimum 97%, Missing); duodenum: 95.3782% (minimum 99%, Missing); esophagus: 93.8017% (minimum 97%, Missing); heart muscle: 73.2258% (minimum 99%, Missing); hippocampal formation: 94.5833% (minimum 99%, Missing); hypothalamus: 94.1909% (minimum 99%, Missing); kidney: 85.9848% (minimum 99%, Missing); liver: 91.9028% (minimum 99%, Missing); lung: 86.9732% (minimum 99%, Missing); lymph node: 88.3268% (minimum 97%, Missing); midbrain: 95.3782% (minimum 99%, Missing); pancreas: 92.2764% (minimum 99%, Uncertain); parathyroid gland: 74.6711% (minimum 97%, Missing); pituitary gland: 89.0196% (minimum 99%, Missing); rectum: 93.4156% (minimum 97%, Missing); retina: 79.6491% (minimum 99%, Missing); salivary gland: 93.4156% (minimum 97%, Missing); skeletal muscle: 98.2684% (minimum 99%, Missing); skin: 91.5323% (minimum 95%, Missing); small intestine: 92.2764% (minimum 99%, Missing); smooth muscle: 86.9732% (minimum 99%, Missing); spinal cord: 94.5833% (minimum 99%, Missing); spleen: 91.9028% (minimum 95%, Missing); stomach: 90.8000% (minimum 97%, Missing); thymus: 88.6719% (minimum 95%, Missing); thyroid gland: 82.8467% (minimum 95%, Missing); urinary bladder: 92.6531% (minimum 97%, Uncertain)",0,2,partial,8.4,7.7,4.7,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 2); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168038,ULK4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.121533,-0.223289,-0.260096
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,8.9,3.5,6.9,"skeletal muscle: 8.9 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168061,SAC3D1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.9762% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.8780% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.5161% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.9114% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.6082% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.5955% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.4395% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.8291% (minimum 99%, Baseline (adaptation disabled)); colon: 78.9157% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.8642% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.9157% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.9744% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.9744% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.0649% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.7550% (minimum 99%, Baseline (adaptation disabled)); liver: 78.4431% (minimum 99%, Baseline (adaptation disabled)); lung: 86.7550% (minimum 99%, Baseline (adaptation disabled)); lymph node: 82.9114% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.0649% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.9114% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.6084% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.9114% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.6084% (minimum 97%, Baseline (adaptation disabled)); retina: 96.3235% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.4395% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 59.5455% (minimum 99%, Baseline (adaptation disabled)); skin: 78.4431% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.9744% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.5161% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.3665% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.3899% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.5000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.9722% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.1842% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.9744% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,8.9,3.5,6.9,"skeletal muscle: 8.9 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168061,SAC3D1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.295,-0.180843,-0.394545
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 77.9762% (minimum 95%, Missing); adrenal gland: 79.8780% (minimum 99%, Missing); amygdala: 84.5161% (minimum 99%, Missing); basal ganglia: 82.9114% (minimum 99%, Missing); bone marrow: 76.6082% (minimum 99%, Uncertain); cerebellum: 73.5955% (minimum 99%, Missing); cerebral cortex: 83.4395% (minimum 99%, Missing); choroid plexus: 65.8291% (minimum 99%, Missing); colon: 78.9157% (minimum 97%, Missing); duodenum: 80.8642% (minimum 99%, Missing); esophagus: 78.9157% (minimum 97%, Missing); heart muscle: 83.9744% (minimum 99%, Missing); hippocampal formation: 83.9744% (minimum 99%, Missing); hypothalamus: 85.0649% (minimum 99%, Missing); kidney: 86.7550% (minimum 99%, Missing); liver: 78.4431% (minimum 99%, Missing); lung: 86.7550% (minimum 99%, Missing); lymph node: 82.9114% (minimum 97%, Missing); midbrain: 85.0649% (minimum 99%, Missing); pancreas: 82.9114% (minimum 99%, Missing); parathyroid gland: 91.6084% (minimum 97%, Missing); pituitary gland: 82.9114% (minimum 99%, Missing); rectum: 91.6084% (minimum 97%, Missing); retina: 96.3235% (minimum 99%, Missing); salivary gland: 83.4395% (minimum 97%, Missing); skeletal muscle: 59.5455% (minimum 99%, Missing); skin: 78.4431% (minimum 95%, Missing); small intestine: 83.9744% (minimum 99%, Missing); smooth muscle: 87.3333% (minimum 99%, Missing); spinal cord: 84.5161% (minimum 99%, Missing); spleen: 81.3665% (minimum 95%, Missing); stomach: 82.3899% (minimum 97%, Missing); thymus: 65.5000% (minimum 95%, Missing); thyroid gland: 90.9722% (minimum 95%, Missing); tongue: 86.1842% (minimum 97%, Missing); urinary bladder: 83.9744% (minimum 97%, Missing)",0,7,partial,8.9,3.5,6.9,"skeletal muscle: 8.9 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); amygdala: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168061,SAC3D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.295,-0.180843,-0.394545
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.3,1.4,1.2,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168070,MAJIN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.1982% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.3723% (minimum 99%, Baseline (adaptation disabled)); liver: 95.1965% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.9655% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.6425% (minimum 99%, Baseline (adaptation disabled)); skin: 94.7826% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.1982% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.3,1.4,1.2,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168070,MAJIN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,-0.00217391,-0.0303448,-0.0462771
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.1982% (minimum 99%, Missing); kidney: 94.3723% (minimum 99%, Missing); liver: 95.1965% (minimum 99%, Missing); lymph node: 93.9655% (minimum 97%, Missing); pancreas: 98.6425% (minimum 99%, Missing); skin: 94.7826% (minimum 95%, Missing); small intestine: 98.1982% (minimum 99%, Missing)",0,80,unavailable,1.3,1.4,1.2,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168070,MAJIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,-0.00217391,-0.0303448,-0.0462771
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,9,12.5,22.2,"thymus: 22.2 nTPM (manageable, limit 5); lymph node: 12.5 nTPM (protected, limit 2); bone marrow: 9 nTPM (vital, limit 6); duodenum: 8.1 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6)",lymph node / germinal center cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000168078,PBK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 88.3420% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.8406% (minimum 99%, Baseline (adaptation disabled)); colon: 88.8021% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.3840% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.4209% (minimum 97%, Baseline (adaptation disabled)); liver: 98.4127% (minimum 99%, Baseline (adaptation disabled)); lung: 98.9840% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.5105% (minimum 97%, Baseline (adaptation disabled)); rectum: 87.4359% (minimum 97%, Baseline (adaptation disabled)); skin: 93.5528% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.6189% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.3277% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.1185% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.4425% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,9,12.5,22.2,"thymus: 22.2 nTPM (manageable, limit 5); lymph node: 12.5 nTPM (protected, limit 2); rectum: 9.8 nTPM (protected, limit 2); bone marrow: 9 nTPM (vital, limit 1); colon: 8.6 nTPM (protected, limit 2); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000168078,PBK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.195575,-0.124895,-0.10658
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 88.3420% (minimum 95%, Enhanced); duodenum: 89.3840% (minimum 95%, Enhanced); lymph node: 84.5105% (minimum 97%, Missing); small intestine: 89.6189% (minimum 95%, Enhanced); thymus: 75.4425% (minimum 95%, Missing)",0,3,partial,9,12.5,22.2,"thymus: 22.2 nTPM (manageable, limit 5); lymph node: 12.5 nTPM (protected, limit 2); bone marrow: 9 nTPM (vital, limit 6); duodenum: 8.1 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6)",lymph node / germinal center cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000168078,PBK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.195575,-0.124895,-0.0665803
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,8.4,5.1,5.7,"bone marrow: 8.4 nTPM (vital, limit 2); cerebral cortex: 5.9 nTPM (vital, limit 1); thymus: 5.7 nTPM (manageable, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 4); liver: 4.8 nTPM (vital, limit 2); adrenal gland: 4.6 nTPM (vital, limit 2); urinary bladder: 4.6 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 4); cerebellum: 4.4 nTPM (vital, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); hypothalamus: 3.1 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 2); pancreas: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); hippocampal formation: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000168116,KIAA1586,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.4234% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.8246% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.1304% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.4074% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.0990% (minimum 99%, Baseline (adaptation disabled)); colon: 76.4706% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.2500% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.9837% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.8000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.1304% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.5902% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.2222% (minimum 99%, Baseline (adaptation disabled)); liver: 65.4676% (minimum 99%, Baseline (adaptation disabled)); lung: 77.1186% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.9118% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.5310% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.1186% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.0845% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.6535% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.4483% (minimum 97%, Baseline (adaptation disabled)); retina: 70.5426% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.7778% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.8491% (minimum 99%, Baseline (adaptation disabled)); skin: 79.1304% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.1304% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.4211% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.8246% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.4074% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.9820% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.4865% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.3288% (minimum 95%, Baseline (adaptation disabled)); tongue: 73.9837% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.4234% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,8.4,5.1,5.7,"bone marrow: 8.4 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); thymus: 5.7 nTPM (manageable, limit 5); thyroid gland: 5.5 nTPM (manageable, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 2); liver: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 2); cerebellum: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); hypothalamus: 3.1 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); pancreas: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000168116,KIAA1586,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.335135,-0.329155,-0.47
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.0000% (minimum 90%, Approved); adrenal gland: 66.4234% (minimum 98%, Approved); amygdala: 79.8246% (minimum 99%, Missing); basal ganglia: 79.1304% (minimum 99%, Missing); bone marrow: 52.0000% (minimum 98%, Approved); cerebellum: 67.4074% (minimum 98%, Approved); cerebral cortex: 60.6667% (minimum 99%, Missing); choroid plexus: 90.0990% (minimum 99%, Missing); colon: 76.4706% (minimum 97%, Missing); duodenum: 81.2500% (minimum 99%, Missing); esophagus: 73.9837% (minimum 97%, Missing); heart muscle: 72.8000% (minimum 99%, Missing); hippocampal formation: 79.1304% (minimum 99%, Missing); hypothalamus: 74.5902% (minimum 99%, Missing); kidney: 72.2222% (minimum 99%, Missing); liver: 65.4676% (minimum 98%, Approved); lung: 77.1186% (minimum 98%, Approved); lymph node: 66.9118% (minimum 95%, Approved); midbrain: 80.5310% (minimum 99%, Missing); pancreas: 77.1186% (minimum 99%, Missing); parathyroid gland: 64.0845% (minimum 95%, Approved); pituitary gland: 71.6535% (minimum 99%, Missing); rectum: 78.4483% (minimum 97%, Missing); retina: 70.5426% (minimum 99%, Missing); salivary gland: 77.7778% (minimum 97%, Missing); skeletal muscle: 85.8491% (minimum 99%, Missing); skin: 79.1304% (minimum 95%, Missing); small intestine: 79.1304% (minimum 98%, Approved); smooth muscle: 68.4211% (minimum 99%, Missing); spinal cord: 79.8246% (minimum 99%, Missing); spleen: 67.4074% (minimum 90%, Approved); stomach: 81.9820% (minimum 97%, Missing); thymus: 61.4865% (minimum 95%, Missing); thyroid gland: 62.3288% (minimum 90%, Approved); tongue: 73.9837% (minimum 97%, Missing); urinary bladder: 66.4234% (minimum 97%, Missing)",0,4,partial,8.4,5.1,5.7,"bone marrow: 8.4 nTPM (vital, limit 2); cerebral cortex: 5.9 nTPM (vital, limit 1); thymus: 5.7 nTPM (manageable, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 4); liver: 4.8 nTPM (vital, limit 2); adrenal gland: 4.6 nTPM (vital, limit 2); urinary bladder: 4.6 nTPM (protected, limit 2); lymph node: 4.5 nTPM (protected, limit 4); cerebellum: 4.4 nTPM (vital, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); hypothalamus: 3.1 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 2); pancreas: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); hippocampal formation: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000168116,KIAA1586,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.335135,-0.309155,-0.46
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,False,,0,6,partial,0.2,0.1,0,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168148,H3-4,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1136/jitc-2023-007935,Wang 2016;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"cerebellum: 93.7500% (minimum 99%, Baseline (adaptation disabled)); colon: 96.7742% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.7742% (minimum 97%, Baseline (adaptation disabled)); small intestine: 96.7742% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 96.7742% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,0.2,0.1,0,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168148,H3-4,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1136/jitc-2023-007935,Wang 2016;Carter 2023,0.05,-0.00225806,-0.0525
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"cerebellum: 93.7500% (minimum 99%, Missing); colon: 96.7742% (minimum 97%, Missing); salivary gland: 96.7742% (minimum 97%, Missing); small intestine: 96.7742% (minimum 99%, Missing); urinary bladder: 96.7742% (minimum 97%, Missing)",0,6,partial,0.2,0.1,0,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168148,H3-4,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1136/jitc-2023-007935,Wang 2016;Carter 2023,0.05,-0.00225806,-0.0525
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,5,6.6,4,"tongue: 6.6 nTPM (protected, limit 2); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168152,THAP9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.2500% (minimum 99%, Baseline (adaptation disabled)); amygdala: 74.7126% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.7126% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.4706% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.3133% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.4706% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 81.2500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.2785% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.4156% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.4286% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.4706% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.1489% (minimum 99%, Baseline (adaptation disabled)); liver: 67.7083% (minimum 99%, Baseline (adaptation disabled)); lung: 80.2469% (minimum 99%, Baseline (adaptation disabled)); lymph node: 79.2683% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.8925% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.0337% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 67.7083% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.4286% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.2469% (minimum 97%, Baseline (adaptation disabled)); retina: 60.7477% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.4706% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 56.5217% (minimum 99%, Baseline (adaptation disabled)); skin: 79.2683% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.2785% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.2785% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.2785% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.2785% (minimum 97%, Baseline (adaptation disabled)); thymus: 73.0337% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.9048% (minimum 95%, Baseline (adaptation disabled)); tongue: 49.6183% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 81.2500% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,5,6.6,4,"tongue: 6.6 nTPM (protected, limit 2); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168152,THAP9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.330952,-0.473817,-0.424783
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Missing); adrenal gland: 81.2500% (minimum 99%, Missing); amygdala: 74.7126% (minimum 99%, Missing); basal ganglia: 74.7126% (minimum 99%, Missing); bone marrow: 76.4706% (minimum 99%, Missing); cerebellum: 78.3133% (minimum 99%, Missing); cerebral cortex: 76.4706% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 81.2500% (minimum 97%, Missing); duodenum: 82.2785% (minimum 99%, Missing); esophagus: 84.4156% (minimum 97%, Missing); heart muscle: 71.4286% (minimum 99%, Missing); hippocampal formation: 71.4286% (minimum 99%, Missing); hypothalamus: 76.4706% (minimum 99%, Missing); kidney: 69.1489% (minimum 99%, Missing); liver: 67.7083% (minimum 99%, Missing); lung: 80.2469% (minimum 99%, Missing); lymph node: 79.2683% (minimum 97%, Missing); midbrain: 69.8925% (minimum 99%, Missing); pancreas: 73.0337% (minimum 99%, Missing); parathyroid gland: 67.7083% (minimum 97%, Missing); pituitary gland: 71.4286% (minimum 99%, Missing); rectum: 80.2469% (minimum 97%, Missing); retina: 60.7477% (minimum 99%, Missing); salivary gland: 76.4706% (minimum 97%, Missing); skeletal muscle: 56.5217% (minimum 99%, Missing); skin: 79.2683% (minimum 95%, Missing); small intestine: 82.2785% (minimum 99%, Missing); smooth muscle: 82.2785% (minimum 99%, Missing); spinal cord: 65.0000% (minimum 99%, Missing); spleen: 82.2785% (minimum 95%, Missing); stomach: 82.2785% (minimum 97%, Missing); thymus: 73.0337% (minimum 95%, Missing); thyroid gland: 61.9048% (minimum 95%, Missing); tongue: 49.6183% (minimum 97%, Missing); urinary bladder: 81.2500% (minimum 97%, Missing)",0,2,partial,5,6.6,4,"tongue: 6.6 nTPM (protected, limit 2); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168152,THAP9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.330952,-0.473817,-0.424783
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,280.3,0.1,0.1,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),61,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000168263,KCNV2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 95.9184% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.1569% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.9167% (minimum 99%, Baseline (adaptation disabled)); retina: 1.6491% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.9167% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,280.3,0.1,0.1,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),61,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000168263,KCNV2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;da Silva 2017,0.0291667,0.00916667,-0.973509
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 95.9184% (minimum 99%, Missing); cerebellum: 92.1569% (minimum 95%, Enhanced); retina: 1.6491% (minimum 99%, Missing)",0,1,partial,280.3,0.1,0.1,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),61,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000168263,KCNV2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;da Silva 2017,0.05,0.03,-0.973509
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,101.2,1.9,0,"pancreas: 101.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000168267,PTF1A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 91.3043% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.3043% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.7692% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.3043% (minimum 99%, Baseline (adaptation disabled)); pancreas: 2.0329% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.3043% (minimum 99%, Baseline (adaptation disabled)); retina: 95.4545% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.4545% (minimum 97%, Baseline (adaptation disabled)); small intestine: 95.4545% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.3043% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.5000% (minimum 99%, Baseline (adaptation disabled)); stomach: 52.5000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,101.2,1.9,0,"pancreas: 101.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000168267,PTF1A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.445,-0.969671
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); cerebellum: 91.3043% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); heart muscle: 87.5000% (minimum 99%, Missing); hippocampal formation: 80.7692% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); midbrain: 91.3043% (minimum 99%, Missing); pancreas: 2.0329% (minimum 99%, Missing); pituitary gland: 91.3043% (minimum 99%, Missing); retina: 95.4545% (minimum 99%, Missing); salivary gland: 95.4545% (minimum 97%, Missing); small intestine: 95.4545% (minimum 99%, Missing); smooth muscle: 91.3043% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); stomach: 52.5000% (minimum 97%, Missing)",0,80,unavailable,101.2,1.9,0,"pancreas: 101.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000168267,PTF1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.445,-0.969671
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,1086.6,2.3,0.2,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 6)",cerebral cortex / neuropil: Medium (Enhanced),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000168314,MOBP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.1481% (minimum 99%, Baseline (adaptation disabled)); amygdala: 2.8711% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 4.0091% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 20.3065% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 4.9165% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 9.3805% (minimum 99%, Baseline (adaptation disabled)); colon: 88.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.3636% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 1.9835% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 2.8836% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.6429% (minimum 99%, Baseline (adaptation disabled)); liver: 98.1481% (minimum 99%, Baseline (adaptation disabled)); lung: 89.8305% (minimum 99%, Baseline (adaptation disabled)); midbrain: 1.2206% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1481% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.7368% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.6429% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.3636% (minimum 97%, Baseline (adaptation disabled)); retina: 96.3636% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.6429% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.3636% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.1481% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.1481% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 0.4854% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 94.6429% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,1086.6,2.3,0.2,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2)",cerebral cortex / neuropil: Medium (Enhanced),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000168314,MOBP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0136364,-0.272632,-0.985146
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 2.8711% (minimum 99%, Missing); basal ganglia: 4.0091% (minimum 99%, Missing); cerebellum: 20.3065% (minimum 95%, Enhanced); cerebral cortex: 4.9165% (minimum 99%, Missing); choroid plexus: 9.3805% (minimum 99%, Missing); hippocampal formation: 1.9835% (minimum 99%, Missing); hypothalamus: 2.8836% (minimum 99%, Missing); kidney: 94.6429% (minimum 95%, Enhanced); lung: 89.8305% (minimum 95%, Enhanced); midbrain: 1.2206% (minimum 99%, Missing); parathyroid gland: 69.7368% (minimum 80%, Enhanced); pituitary gland: 94.6429% (minimum 99%, Missing); retina: 96.3636% (minimum 99%, Missing); spinal cord: 0.4854% (minimum 99%, Missing)",0,2,partial,1086.6,2.3,0.2,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 6)",cerebral cortex / neuropil: Medium (Enhanced),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000168314,MOBP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,-0.102632,-0.985146
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,37.7,19.1,18.1,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 2); thymus: 18.1 nTPM (manageable, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.4 nTPM (manageable, limit 5); retina: 14.3 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 2); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 2); skeletal muscle: 11.2 nTPM (vital, limit 1); stomach: 11.1 nTPM (protected, limit 2); tongue: 11.1 nTPM (protected, limit 2); salivary gland: 10.7 nTPM (protected, limit 2); small intestine: 10.7 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); lung: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 2); skin: 10.3 nTPM (manageable, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168438,CDC40,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.0281% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.4378% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 50.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 27.3603% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.2807% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 52.3985% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.2692% (minimum 99%, Baseline (adaptation disabled)); colon: 57.0281% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.0281% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.7236% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.4362% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.2581% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.5990% (minimum 99%, Baseline (adaptation disabled)); kidney: 47.4916% (minimum 99%, Baseline (adaptation disabled)); liver: 46.5574% (minimum 99%, Baseline (adaptation disabled)); lung: 57.2581% (minimum 99%, Baseline (adaptation disabled)); lymph node: 42.6426% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.6468% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.1985% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.2635% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 60.6838% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.8263% (minimum 97%, Baseline (adaptation disabled)); retina: 49.8246% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.0281% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.9055% (minimum 99%, Baseline (adaptation disabled)); skin: 57.9592% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.0281% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.1667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.6190% (minimum 99%, Baseline (adaptation disabled)); spleen: 47.6510% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.1265% (minimum 97%, Baseline (adaptation disabled)); thymus: 43.9628% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 47.9730% (minimum 95%, Baseline (adaptation disabled)); tongue: 56.1265% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.7879% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,37.7,19.1,18.1,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 2); thymus: 18.1 nTPM (manageable, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.4 nTPM (manageable, limit 5); retina: 14.3 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 2); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 2); skeletal muscle: 11.2 nTPM (vital, limit 1); stomach: 11.1 nTPM (protected, limit 2); tongue: 11.1 nTPM (protected, limit 2); salivary gland: 10.7 nTPM (protected, limit 2); small intestine: 10.7 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); lung: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 2); skin: 10.3 nTPM (manageable, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168438,CDC40,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.510372,-0.543574,-0.716397
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.0281% (minimum 95%, Missing); adrenal gland: 50.0000% (minimum 99%, Missing); amygdala: 65.4378% (minimum 99%, Missing); basal ganglia: 50.0000% (minimum 99%, Missing); bone marrow: 27.3603% (minimum 99%, Missing); cerebellum: 62.2807% (minimum 99%, Missing); cerebral cortex: 52.3985% (minimum 99%, Missing); choroid plexus: 68.2692% (minimum 99%, Missing); colon: 57.0281% (minimum 97%, Missing); duodenum: 57.0281% (minimum 99%, Missing); esophagus: 57.7236% (minimum 97%, Missing); heart muscle: 58.4362% (minimum 99%, Missing); hippocampal formation: 57.2581% (minimum 99%, Missing); hypothalamus: 68.5990% (minimum 99%, Missing); kidney: 47.4916% (minimum 99%, Missing); liver: 46.5574% (minimum 99%, Missing); lung: 57.2581% (minimum 99%, Missing); lymph node: 42.6426% (minimum 97%, Missing); midbrain: 70.6468% (minimum 99%, Missing); pancreas: 54.1985% (minimum 99%, Missing); parathyroid gland: 51.2635% (minimum 97%, Missing); pituitary gland: 60.6838% (minimum 99%, Missing); rectum: 54.8263% (minimum 97%, Missing); retina: 49.8246% (minimum 99%, Missing); salivary gland: 57.0281% (minimum 97%, Missing); skeletal muscle: 55.9055% (minimum 99%, Missing); skin: 57.9592% (minimum 95%, Missing); small intestine: 57.0281% (minimum 99%, Missing); smooth muscle: 59.1667% (minimum 99%, Missing); spinal cord: 67.6190% (minimum 99%, Missing); spleen: 47.6510% (minimum 95%, Missing); stomach: 56.1265% (minimum 97%, Missing); thymus: 43.9628% (minimum 95%, Missing); thyroid gland: 47.9730% (minimum 95%, Missing); tongue: 56.1265% (minimum 97%, Missing); urinary bladder: 53.7879% (minimum 97%, Missing)",0,80,unavailable,37.7,19.1,18.1,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 2); thymus: 18.1 nTPM (manageable, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.4 nTPM (manageable, limit 5); retina: 14.3 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 2); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 2); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 2); skeletal muscle: 11.2 nTPM (vital, limit 1); stomach: 11.1 nTPM (protected, limit 2); tongue: 11.1 nTPM (protected, limit 2); salivary gland: 10.7 nTPM (protected, limit 2); small intestine: 10.7 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); lung: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 2); skin: 10.3 nTPM (manageable, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168438,CDC40,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.510372,-0.543574,-0.716397
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 1 / melanocytes,ENSG00000168454,TXNDC2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 1 / melanocytes,ENSG00000168454,TXNDC2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.048995,0.028995,0.00699097
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 1 / melanocytes,ENSG00000168454,TXNDC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.028995,0.00899497
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,29.7,6,7.5,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 2); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168491,CCDC110,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.3789% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0808% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6789% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.6789% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.8798% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5879% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.5773% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1972% (minimum 99%, Baseline (adaptation disabled)); retina: 92.6527% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.1804% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.9818% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6789% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 92.8298% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,29.7,6,7.5,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 2); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168491,CCDC110,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0217017,-0.0281959,-0.224227
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.3789% (minimum 99%, Missing); cerebellum: 98.0808% (minimum 99%, Missing); cerebral cortex: 98.6789% (minimum 99%, Missing); choroid plexus: 98.6789% (minimum 99%, Missing); heart muscle: 98.8798% (minimum 99%, Missing); kidney: 97.5879% (minimum 99%, Missing); pancreas: 76.5773% (minimum 99%, Missing); pituitary gland: 97.1972% (minimum 99%, Missing); retina: 92.6527% (minimum 99%, Missing); salivary gland: 94.1804% (minimum 97%, Missing); skeletal muscle: 97.9818% (minimum 99%, Missing); smooth muscle: 98.6789% (minimum 99%, Missing); thyroid gland: 92.8298% (minimum 95%, Missing)",0,80,unavailable,29.7,6,7.5,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 2); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168491,CCDC110,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0217017,-0.0281959,-0.224227
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000168515,SCGB1D1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 92.3077% (minimum 97%, Baseline (adaptation disabled)); hypothalamus: 92.3077% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.3077% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.6667% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000168515,SCGB1D1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,-0.0469231,-0.0669231
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 92.3077% (minimum 97%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); salivary gland: 92.3077% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing)",0,80,unavailable,0.1,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000168515,SCGB1D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,-0.0469231,-0.0669231
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,56.3,4.4,3.2,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168589,DYNLRB2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9247% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.1672% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.1314% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.5274% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.6824% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.0495% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.0904% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5265% (minimum 99%, Baseline (adaptation disabled)); lung: 97.3974% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.1831% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.1333% (minimum 99%, Baseline (adaptation disabled)); retina: 98.2206% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.5265% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,56.3,4.4,3.2,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168589,DYNLRB2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0357143,0.0104618,-0.193176
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9247% (minimum 99%, Missing); amygdala: 96.1672% (minimum 99%, Missing); basal ganglia: 95.1314% (minimum 99%, Missing); cerebral cortex: 98.5274% (minimum 99%, Missing); choroid plexus: 79.6824% (minimum 99%, Missing); hippocampal formation: 95.0495% (minimum 99%, Missing); hypothalamus: 95.0904% (minimum 99%, Missing); kidney: 97.5265% (minimum 99%, Missing); lung: 97.3974% (minimum 99%, Missing); midbrain: 97.1831% (minimum 99%, Missing); pituitary gland: 98.1333% (minimum 99%, Missing); retina: 98.2206% (minimum 99%, Missing); spinal cord: 97.5265% (minimum 99%, Missing)",0,80,unavailable,56.3,4.4,3.2,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168589,DYNLRB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0357143,0.0104618,-0.193176
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000168594,ADAM29,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000168594,ADAM29,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0275,0.00501247
True,compatible,,True,True,True,,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000168594,ADAM29,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0275,0.00501247
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000168619,ADAM18,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 98.8889% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000168619,ADAM18,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00111111
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 98.8889% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000168619,ADAM18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00111111
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,False,,0,5,partial,9.1,0.1,0.7,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000168658,VWA3B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"amygdala: 97.6589% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.7377% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.2402% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.3696% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.3696% (minimum 99%, Baseline (adaptation disabled)); lung: 92.4051% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,9.1,0.1,0.7,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000168658,VWA3B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0265886,0.026587,-0.227598
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"amygdala: 97.6589% (minimum 99%, Missing); basal ganglia: 95.7377% (minimum 99%, Missing); choroid plexus: 76.2402% (minimum 99%, Missing); hippocampal formation: 96.3696% (minimum 99%, Missing); hypothalamus: 96.3696% (minimum 99%, Missing); lung: 92.4051% (minimum 98%, Approved)",0,5,partial,9.1,0.1,0.7,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000168658,VWA3B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0265886,0.026587,-0.227598
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.3,0.6,1.6,"bone marrow: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168676,KCTD19,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 97.2644% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.6516% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.1595% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.1595% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.3,0.6,1.6,"bone marrow: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168676,KCTD19,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.00238095,0.0115951,-0.0834844
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 97.2644% (minimum 99%, Missing); bone marrow: 90.6516% (minimum 99%, Missing); choroid plexus: 98.1595% (minimum 99%, Missing); skeletal muscle: 98.1595% (minimum 99%, Missing)",0,80,unavailable,3.3,0.6,1.6,"bone marrow: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168676,KCTD19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.00238095,0.0115951,-0.0834844
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,9.7,3.4,5.5,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000168702,LRP1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 42.3077% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.8571% (minimum 99%, Baseline (adaptation disabled)); amygdala: 20.7547% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 21.5686% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 28.9474% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 18.4874% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.7500% (minimum 99%, Baseline (adaptation disabled)); colon: 88.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 24.7191% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 25.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.6154% (minimum 99%, Baseline (adaptation disabled)); liver: 95.6522% (minimum 99%, Baseline (adaptation disabled)); lung: 95.6522% (minimum 99%, Baseline (adaptation disabled)); midbrain: 22.2222% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.6522% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.6522% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 53.6585% (minimum 99%, Baseline (adaptation disabled)); retina: 46.8085% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.5714% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 33.8462% (minimum 99%, Baseline (adaptation disabled)); skin: 84.6154% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.6522% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 31.8841% (minimum 99%, Baseline (adaptation disabled)); stomach: 84.6154% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 28.5714% (minimum 95%, Baseline (adaptation disabled)); tongue: 39.2857% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,9.7,3.4,5.5,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000168702,LRP1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.664286,-0.577143,-0.805126
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 42.3077% (minimum 95%, Missing); adrenal gland: 62.8571% (minimum 99%, Missing); amygdala: 20.7547% (minimum 99%, Missing); basal ganglia: 21.5686% (minimum 99%, Missing); cerebellum: 28.9474% (minimum 99%, Missing); cerebral cortex: 18.4874% (minimum 99%, Missing); choroid plexus: 68.7500% (minimum 99%, Missing); colon: 88.0000% (minimum 95%, Approved); heart muscle: 88.0000% (minimum 98%, Approved); hippocampal formation: 24.7191% (minimum 99%, Missing); hypothalamus: 25.0000% (minimum 99%, Missing); kidney: 84.6154% (minimum 98%, Approved); liver: 95.6522% (minimum 98%, Approved); lung: 95.6522% (minimum 98%, Approved); midbrain: 22.2222% (minimum 99%, Missing); pancreas: 95.6522% (minimum 98%, Approved); pituitary gland: 53.6585% (minimum 99%, Missing); retina: 46.8085% (minimum 99%, Missing); salivary gland: 78.5714% (minimum 95%, Approved); skeletal muscle: 33.8462% (minimum 99%, Missing); skin: 84.6154% (minimum 90%, Approved); small intestine: 95.6522% (minimum 98%, Approved); spinal cord: 31.8841% (minimum 99%, Missing); stomach: 84.6154% (minimum 95%, Approved); thymus: 91.6667% (minimum 95%, Missing); thyroid gland: 28.5714% (minimum 95%, Missing); tongue: 39.2857% (minimum 97%, Missing)",0,1,partial,9.7,3.4,5.5,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000168702,LRP1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.664286,-0.577143,-0.805126
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000168757,TSPY2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000168757,TSPY2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000168757,TSPY2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,45.6,17.6,22,"liver: 45.6 nTPM (vital, limit 1); thymus: 22 nTPM (manageable, limit 5); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 2); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); skin: 10.1 nTPM (manageable, limit 5); rectum: 9.4 nTPM (protected, limit 2); heart muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 2); parathyroid gland: 9.1 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); colon: 7.7 nTPM (protected, limit 2); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 2); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); urinary bladder: 6.3 nTPM (protected, limit 2); salivary gland: 6 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168904,LRRC28,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.9661% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.4091% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.0662% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.8981% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.4543% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.3837% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.4489% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.2290% (minimum 99%, Baseline (adaptation disabled)); colon: 78.1870% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.7273% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.7967% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.5946% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.0662% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.5204% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.6112% (minimum 99%, Baseline (adaptation disabled)); liver: 37.7049% (minimum 99%, Baseline (adaptation disabled)); lung: 84.4037% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.4665% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.7925% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.3548% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.2044% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.3418% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.5946% (minimum 97%, Baseline (adaptation disabled)); retina: 80.7018% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.1429% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.9272% (minimum 99%, Baseline (adaptation disabled)); skin: 73.2095% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.3028% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.4091% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.1852% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.1852% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.7465% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.6452% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.1765% (minimum 95%, Baseline (adaptation disabled)); tongue: 61.0619% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 81.4159% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,45.6,17.6,22,"liver: 45.6 nTPM (vital, limit 1); thymus: 22 nTPM (manageable, limit 5); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 2); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); skin: 10.1 nTPM (manageable, limit 5); rectum: 9.4 nTPM (protected, limit 2); heart muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 2); parathyroid gland: 9.1 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); colon: 7.7 nTPM (protected, limit 2); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 2); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); urinary bladder: 6.3 nTPM (protected, limit 2); salivary gland: 6 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168904,LRRC28,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.393548,-0.359381,-0.612951
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 77.9661% (minimum 95%, Missing); adrenal gland: 78.4091% (minimum 99%, Missing); amygdala: 87.0662% (minimum 99%, Missing); basal ganglia: 87.8981% (minimum 99%, Missing); bone marrow: 76.4543% (minimum 99%, Missing); cerebellum: 83.3837% (minimum 99%, Missing); cerebral cortex: 85.4489% (minimum 99%, Missing); choroid plexus: 70.2290% (minimum 99%, Missing); colon: 78.1870% (minimum 97%, Missing); duodenum: 62.7273% (minimum 99%, Missing); esophagus: 74.7967% (minimum 97%, Missing); heart muscle: 74.5946% (minimum 99%, Missing); hippocampal formation: 87.0662% (minimum 99%, Missing); hypothalamus: 86.5204% (minimum 99%, Missing); kidney: 59.6112% (minimum 99%, Missing); liver: 37.7049% (minimum 99%, Missing); lung: 84.4037% (minimum 99%, Missing); lymph node: 80.4665% (minimum 97%, Missing); midbrain: 86.7925% (minimum 99%, Missing); pancreas: 59.3548% (minimum 99%, Missing); parathyroid gland: 75.2044% (minimum 97%, Missing); pituitary gland: 87.3418% (minimum 99%, Missing); rectum: 74.5946% (minimum 97%, Missing); retina: 80.7018% (minimum 99%, Missing); salivary gland: 82.1429% (minimum 97%, Missing); skeletal muscle: 60.9272% (minimum 99%, Missing); skin: 73.2095% (minimum 95%, Missing); small intestine: 63.3028% (minimum 99%, Missing); smooth muscle: 78.4091% (minimum 99%, Missing); spinal cord: 85.1852% (minimum 99%, Missing); spleen: 85.1852% (minimum 95%, Missing); stomach: 77.7465% (minimum 97%, Missing); thymus: 55.6452% (minimum 95%, Missing); thyroid gland: 81.1765% (minimum 95%, Missing); tongue: 61.0619% (minimum 97%, Missing); urinary bladder: 81.4159% (minimum 97%, Missing)",0,4,partial,45.6,17.6,22,"liver: 45.6 nTPM (vital, limit 1); thymus: 22 nTPM (manageable, limit 5); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 2); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); skin: 10.1 nTPM (manageable, limit 5); rectum: 9.4 nTPM (protected, limit 2); heart muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 2); parathyroid gland: 9.1 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 2); adipose tissue: 7.8 nTPM (manageable, limit 5); colon: 7.7 nTPM (protected, limit 2); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 2); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); urinary bladder: 6.3 nTPM (protected, limit 2); salivary gland: 6 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000168904,LRRC28,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.393548,-0.359381,-0.612951
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000168930,TRIM49,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000168930,TRIM49,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000168930,TRIM49,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.2,9.1,13.6,"thymus: 13.6 nTPM (manageable, limit 5); retina: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 2); spleen: 8.8 nTPM (manageable, limit 5); thyroid gland: 8 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 2); pancreas: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 2); midbrain: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); rectum: 5 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 2); cerebral cortex: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168944,CEP120,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6168% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.3366% (minimum 99%, Baseline (adaptation disabled)); amygdala: 74.8603% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.2240% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.2086% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.4715% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.1364% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 66.0099% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.0331% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.7062% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.0722% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.0430% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.7179% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 63.5071% (minimum 99%, Baseline (adaptation disabled)); lung: 65.3659% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.5556% (minimum 97%, Baseline (adaptation disabled)); midbrain: 72.0430% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.7179% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.7343% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.6768% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.8261% (minimum 97%, Baseline (adaptation disabled)); retina: 54.4715% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.8261% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.1364% (minimum 99%, Baseline (adaptation disabled)); skin: 77.0115% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.3659% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.5071% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.3604% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.2240% (minimum 97%, Baseline (adaptation disabled)); thymus: 49.6296% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.6168% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.4301% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.6768% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.2,9.1,13.6,"thymus: 13.6 nTPM (manageable, limit 5); retina: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 2); spleen: 8.8 nTPM (manageable, limit 5); thyroid gland: 8 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 2); pancreas: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 2); midbrain: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); rectum: 5 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 2); cerebral cortex: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168944,CEP120,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.453704,-0.374444,-0.445285
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6168% (minimum 95%, Missing); adrenal gland: 66.3366% (minimum 99%, Missing); amygdala: 74.8603% (minimum 99%, Missing); basal ganglia: 73.2240% (minimum 99%, Missing); bone marrow: 82.2086% (minimum 99%, Missing); cerebellum: 54.4715% (minimum 99%, Missing); cerebral cortex: 76.1364% (minimum 99%, Missing); choroid plexus: 89.3333% (minimum 99%, Missing); colon: 66.0099% (minimum 97%, Missing); duodenum: 74.0331% (minimum 99%, Missing); esophagus: 75.7062% (minimum 97%, Missing); heart muscle: 69.0722% (minimum 99%, Missing); hippocampal formation: 72.0430% (minimum 99%, Missing); hypothalamus: 68.7179% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 63.5071% (minimum 99%, Missing); lung: 65.3659% (minimum 99%, Missing); lymph node: 59.5556% (minimum 97%, Missing); midbrain: 72.0430% (minimum 99%, Missing); pancreas: 68.7179% (minimum 99%, Missing); parathyroid gland: 64.7343% (minimum 97%, Missing); pituitary gland: 67.6768% (minimum 99%, Missing); rectum: 72.8261% (minimum 97%, Missing); retina: 54.4715% (minimum 99%, Missing); salivary gland: 72.8261% (minimum 97%, Missing); skeletal muscle: 76.1364% (minimum 99%, Missing); skin: 77.0115% (minimum 95%, Missing); small intestine: 65.3659% (minimum 99%, Missing); smooth muscle: 63.5071% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 60.3604% (minimum 95%, Missing); stomach: 73.2240% (minimum 97%, Missing); thymus: 49.6296% (minimum 95%, Missing); thyroid gland: 62.6168% (minimum 95%, Missing); tongue: 69.4301% (minimum 97%, Missing); urinary bladder: 67.6768% (minimum 97%, Missing)",0,80,unavailable,11.2,9.1,13.6,"thymus: 13.6 nTPM (manageable, limit 5); retina: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 2); spleen: 8.8 nTPM (manageable, limit 5); thyroid gland: 8 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 2); pancreas: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 2); midbrain: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 2); rectum: 5 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 2); cerebral cortex: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000168944,CEP120,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.453704,-0.374444,-0.445285
True,compatible,,True,True,False,,0,1,partial,0.4,0.1,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000169059,VCX3A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.4,0.1,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000169059,VCX3A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0462617,0.0281273,0.00255121
True,compatible,,True,True,True,,0,1,partial,0.4,0.1,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000169059,VCX3A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.00255121
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,13.3,0.2,0.1,"choroid plexus: 13.3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000169064,ZBBX,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.4088% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.5657% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.5729% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.4066% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.8172% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.5729% (minimum 99%, Baseline (adaptation disabled)); lung: 91.1227% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.5799% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8669% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,13.3,0.2,0.1,"choroid plexus: 13.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000169064,ZBBX,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0471429,0.024302,-0.265934
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.4088% (minimum 99%, Missing); basal ganglia: 93.5657% (minimum 99%, Missing); cerebral cortex: 92.5729% (minimum 95%, Enhanced); choroid plexus: 72.4066% (minimum 99%, Missing); hippocampal formation: 93.8172% (minimum 99%, Missing); hypothalamus: 92.5729% (minimum 99%, Missing); lung: 91.1227% (minimum 95%, Enhanced); pituitary gland: 94.5799% (minimum 99%, Missing); spinal cord: 98.8669% (minimum 99%, Missing)",0,4,partial,13.3,0.2,0.1,"choroid plexus: 13.3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000169064,ZBBX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0471429,0.03,-0.265934
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,7.8,1,0.5,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus,ENSG00000169126,ODAD2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.7723% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5037% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.5309% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.7500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.9975% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.5095% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.5309% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2906% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2587% (minimum 99%, Baseline (adaptation disabled)); lung: 94.0476% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.7230% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7500% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,7.8,1,0.5,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus,ENSG00000169126,ODAD2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0375,0.00530864,-0.154905
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.5037% (minimum 99%, Missing); basal ganglia: 97.5309% (minimum 99%, Missing); choroid plexus: 83.5095% (minimum 99%, Missing); hippocampal formation: 97.5309% (minimum 99%, Missing); hypothalamus: 97.2906% (minimum 99%, Missing); lung: 94.0476% (minimum 95%, Enhanced); pituitary gland: 92.7230% (minimum 99%, Missing)",0,3,partial,7.8,1,0.5,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus,ENSG00000169126,ODAD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0375,0.0224623,-0.154905
True,compatible,,True,True,False,,0,80,unavailable,0,0.1,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000169154,GOT1L1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0.1,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000169154,GOT1L1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.0227536,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0.1,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000169154,GOT1L1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.0227536,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,28.5,2.6,4.8,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 2); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 2); kidney: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); salivary gland / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000169169,CPT1C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 70.2703% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 30.1158% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 24.8408% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 22.5434% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 23.6364% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 21.4876% (minimum 99%, Baseline (adaptation disabled)); colon: 75.7282% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.7143% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.6364% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.8261% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 27.3684% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 27.6596% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.9787% (minimum 99%, Baseline (adaptation disabled)); liver: 90.6977% (minimum 99%, Baseline (adaptation disabled)); lung: 79.5918% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.7143% (minimum 97%, Baseline (adaptation disabled)); midbrain: 39.1960% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.7143% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.7826% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 22.0339% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.8571% (minimum 97%, Baseline (adaptation disabled)); retina: 39.1960% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.6552% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.7647% (minimum 99%, Baseline (adaptation disabled)); skin: 88.6364% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.2500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.9344% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 40.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.9048% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.8710% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 77.2277% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,28.5,2.6,4.8,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); salivary gland / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000169169,CPT1C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.330952,-0.22,-0.775124
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 70.2703% (minimum 90%, Approved); adrenal gland: 60.0000% (minimum 98%, Approved); amygdala: 30.1158% (minimum 99%, Missing); basal ganglia: 24.8408% (minimum 99%, Missing); cerebellum: 22.5434% (minimum 99%, Missing); cerebral cortex: 23.6364% (minimum 99%, Missing); choroid plexus: 21.4876% (minimum 99%, Missing); colon: 75.7282% (minimum 95%, Approved); duodenum: 85.7143% (minimum 98%, Approved); esophagus: 88.6364% (minimum 95%, Approved); heart muscle: 67.8261% (minimum 98%, Approved); hippocampal formation: 27.3684% (minimum 99%, Missing); hypothalamus: 27.6596% (minimum 99%, Missing); kidney: 82.9787% (minimum 99%, Missing); liver: 90.6977% (minimum 98%, Approved); lung: 79.5918% (minimum 98%, Approved); lymph node: 85.7143% (minimum 95%, Approved); midbrain: 39.1960% (minimum 99%, Missing); pancreas: 85.7143% (minimum 98%, Approved); parathyroid gland: 84.7826% (minimum 95%, Approved); pituitary gland: 22.0339% (minimum 99%, Missing); rectum: 92.8571% (minimum 95%, Approved); retina: 39.1960% (minimum 99%, Missing); salivary gland: 89.6552% (minimum 97%, Missing); skeletal muscle: 91.7647% (minimum 98%, Approved); skin: 88.6364% (minimum 90%, Approved); small intestine: 81.2500% (minimum 98%, Approved); smooth muscle: 63.9344% (minimum 99%, Missing); spinal cord: 40.0000% (minimum 99%, Missing); spleen: 61.9048% (minimum 90%, Approved); stomach: 83.8710% (minimum 97%, Missing); thyroid gland: 77.2277% (minimum 90%, Approved); urinary bladder: 75.0000% (minimum 95%, Approved)",0,2,partial,28.5,2.6,4.8,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 2); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 2); kidney: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); salivary gland / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000169169,CPT1C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.280952,-0.2,-0.775124
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,ENSG00000169194,IL13,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,ENSG00000169194,IL13,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0333333,0.0215966,0.00159664
True,compatible,,True,True,True,,0,80,unavailable,0.2,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,ENSG00000169194,IL13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0333333,0.0215966,0.00159664
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000169214,OR6F1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000169214,OR6F1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000169214,OR6F1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,0,routine_complete,9,11.6,6.2,"lymph node: 11.6 nTPM (protected, limit 2); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); stomach: 6.1 nTPM (protected, limit 2); lung: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169248,CXCL11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.3396% (minimum 99%, Baseline (adaptation disabled)); amygdala: 35.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.4638% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.3396% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.5926% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.0769% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.3396% (minimum 99%, Baseline (adaptation disabled)); colon: 75.7576% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.2069% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.6452% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.7284% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.1395% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.3651% (minimum 99%, Baseline (adaptation disabled)); liver: 68.4932% (minimum 99%, Baseline (adaptation disabled)); lung: 46.2963% (minimum 99%, Baseline (adaptation disabled)); lymph node: 30.1205% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.9351% (minimum 99%, Baseline (adaptation disabled)); pancreas: 36.7647% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.1538% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.3478% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.3396% (minimum 99%, Baseline (adaptation disabled)); small intestine: 80.6452% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.7576% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 48.0769% (minimum 99%, Baseline (adaptation disabled)); spleen: 47.1698% (minimum 95%, Baseline (adaptation disabled)); stomach: 45.0450% (minimum 97%, Baseline (adaptation disabled)); thymus: 44.6429% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 80.6452% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 52.6316% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,9,11.6,6.2,"lymph node: 11.6 nTPM (protected, limit 2); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); stomach: 6.1 nTPM (protected, limit 2); lung: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169248,CXCL11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.503571,-0.668795,-0.632857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Uncertain); adrenal gland: 94.3396% (minimum 99%, Uncertain); amygdala: 35.7143% (minimum 99%, Missing); basal ganglia: 72.4638% (minimum 99%, Missing); bone marrow: 94.3396% (minimum 99%, Uncertain); cerebellum: 92.5926% (minimum 99%, Uncertain); cerebral cortex: 48.0769% (minimum 99%, Uncertain); choroid plexus: 94.3396% (minimum 99%, Missing); colon: 75.7576% (minimum 97%, Uncertain); duodenum: 86.2069% (minimum 99%, Uncertain); esophagus: 83.3333% (minimum 97%, Uncertain); heart muscle: 80.6452% (minimum 99%, Uncertain); hippocampal formation: 61.7284% (minimum 99%, Missing); hypothalamus: 58.1395% (minimum 99%, Missing); kidney: 79.3651% (minimum 99%, Uncertain); liver: 68.4932% (minimum 99%, Uncertain); lung: 46.2963% (minimum 99%, Uncertain); lymph node: 30.1205% (minimum 97%, Uncertain); midbrain: 64.9351% (minimum 99%, Missing); pancreas: 36.7647% (minimum 99%, Uncertain); pituitary gland: 96.1538% (minimum 99%, Missing); rectum: 54.3478% (minimum 97%, Uncertain); salivary gland: 62.5000% (minimum 97%, Uncertain); skeletal muscle: 94.3396% (minimum 99%, Uncertain); small intestine: 80.6452% (minimum 99%, Uncertain); smooth muscle: 75.7576% (minimum 99%, Uncertain); spinal cord: 48.0769% (minimum 99%, Missing); spleen: 47.1698% (minimum 95%, Uncertain); stomach: 45.0450% (minimum 97%, Uncertain); thymus: 44.6429% (minimum 95%, Missing); thyroid gland: 80.6452% (minimum 95%, Uncertain); urinary bladder: 52.6316% (minimum 97%, Uncertain)",0,0,routine_complete,9,11.6,6.2,"lymph node: 11.6 nTPM (protected, limit 2); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); stomach: 6.1 nTPM (protected, limit 2); lung: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169248,CXCL11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.503571,-0.668795,-0.632857
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,0.4,119.4,0.1,"stomach: 119.4 nTPM (protected, limit 2)",stomach 2 / glandular cells: Low (Approved),55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000169340,PDILT,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 97.8261% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.8261% (minimum 99%, Baseline (adaptation disabled)); stomach: 13.1004% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,0.4,119.4,0.1,"stomach: 119.4 nTPM (protected, limit 2)",stomach 2 / glandular cells: Low (Approved),55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000169340,PDILT,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0444751,-0.838996,-0.0117391
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 97.8261% (minimum 98%, Approved); small intestine: 97.8261% (minimum 98%, Approved); stomach: 13.1004% (minimum 97%, Missing)",0,1,partial,0.4,119.4,0.1,"stomach: 119.4 nTPM (protected, limit 2)",stomach 2 / glandular cells: Low (Approved),55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000169340,PDILT,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.838996,-0.00173913
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,72.3,0,0,"retina: 72.3 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000169393,ELSPBP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.4473% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,72.3,0,0,"retina: 72.3 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000169393,ELSPBP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.015527
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.4473% (minimum 99%, Missing)",0,1,partial,72.3,0,0,"retina: 72.3 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000169393,ELSPBP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.015527
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,3.6,1.2,0.3,"choroid plexus: 3.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000169402,RSPH10B2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.9275% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.9391% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.4375% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9529% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.9529% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.9391% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.4545% (minimum 99%, Baseline (adaptation disabled)); lung: 93.5644% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.0299% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.9231% (minimum 99%, Baseline (adaptation disabled)); retina: 98.9529% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9529% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,3.6,1.2,0.3,"choroid plexus: 3.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000169402,RSPH10B2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,0.034375,-0.0297015,-0.15
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 97.9275% (minimum 99%, Missing); basal ganglia: 95.9391% (minimum 99%, Missing); choroid plexus: 84.0000% (minimum 99%, Missing); hippocampal formation: 95.9391% (minimum 99%, Missing); hypothalamus: 95.4545% (minimum 99%, Missing); lung: 93.5644% (minimum 97%, Supported); pituitary gland: 96.9231% (minimum 99%, Missing); retina: 98.9529% (minimum 99%, Missing); spinal cord: 98.9529% (minimum 99%, Missing)",0,4,partial,3.6,1.2,0.3,"choroid plexus: 3.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000169402,RSPH10B2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.15
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,5,partial,6.8,2.2,1,"bone marrow: 6.8 nTPM (vital, limit 6)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169495,HTRA4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.4628% (minimum 99%, Baseline (adaptation disabled)); lung: 97.2851% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.7016% (minimum 97%, Baseline (adaptation disabled)); retina: 98.6239% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,6.8,2.2,1,"bone marrow: 6.8 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); lung: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169495,HTRA4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0347328,-0.00298351,-0.0853717
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.4628% (minimum 95%, Enhanced); retina: 98.6239% (minimum 99%, Missing)",0,5,partial,6.8,2.2,1,"bone marrow: 6.8 nTPM (vital, limit 6)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169495,HTRA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0438367,0.0238367,-0.0453717
True,compatible,,True,True,False,,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,ENSG00000169551,CT55,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 94.8718% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.5000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.5000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.8718% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.3684% (minimum 99%, Baseline (adaptation disabled)); retina: 97.3684% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,ENSG00000169551,CT55,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025,0.0236842,0.03,-0.065
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 94.8718% (minimum 99%, Missing); basal ganglia: 92.5000% (minimum 99%, Missing); cerebral cortex: 92.5000% (minimum 99%, Missing); hippocampal formation: 92.5000% (minimum 99%, Missing); hypothalamus: 94.8718% (minimum 99%, Missing); midbrain: 97.3684% (minimum 99%, Missing); retina: 97.3684% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,ENSG00000169551,CT55,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025,0.0236842,0.03,-0.065
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,10,6.1,8.7,"skeletal muscle: 10 nTPM (vital, limit 2); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 4); liver: 4.3 nTPM (vital, limit 2); esophagus: 4.1 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); colon: 3.1 nTPM (protected, limit 2); smooth muscle: 3 nTPM (vital, limit 2); duodenum: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); cerebellum: 2.8 nTPM (vital, limit 2); small intestine: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000169570,DTWD2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.0253% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.4938% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.7778% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.5625% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.3279% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 63.6364% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.2162% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.9649% (minimum 99%, Baseline (adaptation disabled)); colon: 61.2500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.0253% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.4444% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 43.7500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.5625% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.0323% (minimum 99%, Baseline (adaptation disabled)); kidney: 44.1441% (minimum 99%, Baseline (adaptation disabled)); liver: 53.2609% (minimum 99%, Baseline (adaptation disabled)); lung: 68.0556% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.0141% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.7778% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.8205% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.1277% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.9649% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.4938% (minimum 97%, Baseline (adaptation disabled)); retina: 59.7561% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.2500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 32.8859% (minimum 99%, Baseline (adaptation disabled)); skin: 60.4938% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.0253% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.0588% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.8205% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.0588% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 36.0294% (minimum 95%, Baseline (adaptation disabled)); tongue: 44.5455% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.6364% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,10,6.1,8.7,"skeletal muscle: 10 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 2); liver: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); colon: 3.1 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); smooth muscle: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000169570,DTWD2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.589706,-0.524545,-0.661141
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.0253% (minimum 90%, Approved); adrenal gland: 60.4938% (minimum 99%, Missing); amygdala: 77.7778% (minimum 99%, Missing); basal ganglia: 76.5625% (minimum 99%, Missing); bone marrow: 80.3279% (minimum 99%, Missing); cerebellum: 63.6364% (minimum 98%, Approved); cerebral cortex: 66.2162% (minimum 98%, Approved); choroid plexus: 85.9649% (minimum 99%, Missing); colon: 61.2500% (minimum 97%, Missing); duodenum: 62.0253% (minimum 99%, Missing); esophagus: 54.4444% (minimum 97%, Missing); heart muscle: 43.7500% (minimum 99%, Missing); hippocampal formation: 76.5625% (minimum 99%, Missing); hypothalamus: 79.0323% (minimum 99%, Missing); kidney: 44.1441% (minimum 99%, Missing); liver: 53.2609% (minimum 98%, Approved); lung: 68.0556% (minimum 98%, Approved); lymph node: 69.0141% (minimum 95%, Approved); midbrain: 77.7778% (minimum 99%, Missing); pancreas: 62.8205% (minimum 99%, Missing); parathyroid gland: 52.1277% (minimum 95%, Approved); pituitary gland: 85.9649% (minimum 99%, Missing); rectum: 60.4938% (minimum 97%, Missing); retina: 59.7561% (minimum 99%, Missing); salivary gland: 61.2500% (minimum 97%, Missing); skeletal muscle: 32.8859% (minimum 98%, Approved); skin: 60.4938% (minimum 95%, Missing); small intestine: 65.3333% (minimum 99%, Missing); smooth muscle: 62.0253% (minimum 98%, Approved); spinal cord: 72.0588% (minimum 99%, Missing); spleen: 62.8205% (minimum 95%, Missing); stomach: 65.3333% (minimum 97%, Missing); thymus: 72.0588% (minimum 95%, Missing); thyroid gland: 36.0294% (minimum 90%, Approved); tongue: 44.5455% (minimum 97%, Missing); urinary bladder: 63.6364% (minimum 97%, Missing)",0,5,partial,10,6.1,8.7,"skeletal muscle: 10 nTPM (vital, limit 2); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 4); liver: 4.3 nTPM (vital, limit 2); esophagus: 4.1 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); salivary gland: 3.1 nTPM (protected, limit 2); colon: 3.1 nTPM (protected, limit 2); smooth muscle: 3 nTPM (vital, limit 2); duodenum: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); urinary bladder: 2.8 nTPM (protected, limit 2); cerebellum: 2.8 nTPM (vital, limit 2); small intestine: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000169570,DTWD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.539706,-0.524545,-0.651141
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,1,partial,29.4,0.5,1.1,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000169575,VPREB1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 0.3390% (minimum 99%, Baseline (adaptation disabled)); lymph node: 16.6667% (minimum 97%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 99%, Baseline (adaptation disabled)); thymus: 8.3333% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,29.4,0.5,1.1,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000169575,VPREB1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.866667,-0.803333,-0.98661
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 0.3390% (minimum 99%, Missing); lymph node: 16.6667% (minimum 95%, Approved); small intestine: 50.0000% (minimum 98%, Approved); thymus: 8.3333% (minimum 95%, Missing)",0,1,partial,29.4,0.5,1.1,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000169575,VPREB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.866667,-0.783333,-0.98661
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.3,12.2,14.6,"adipose tissue: 14.6 nTPM (manageable, limit 5); esophagus: 12.2 nTPM (protected, limit 2); skin: 9 nTPM (manageable, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000169594,BNC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6598% (minimum 95%, Baseline (adaptation disabled)); esophagus: 66.7575% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.9612% (minimum 99%, Baseline (adaptation disabled)); lung: 98.7903% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.4567% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 92.8030% (minimum 97%, Baseline (adaptation disabled)); skin: 73.1343% (minimum 95%, Baseline (adaptation disabled)); thymus: 86.5724% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.3,12.2,14.6,"adipose tissue: 14.6 nTPM (manageable, limit 5); esophagus: 12.2 nTPM (protected, limit 2); skin: 9 nTPM (manageable, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000169594,BNC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.323402,-0.302425,-0.0403876
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6598% (minimum 95%, Missing); esophagus: 66.7575% (minimum 97%, Missing); heart muscle: 94.9612% (minimum 99%, Missing); lung: 98.7903% (minimum 99%, Missing); parathyroid gland: 96.4567% (minimum 97%, Missing); salivary gland: 92.8030% (minimum 97%, Missing); skin: 73.1343% (minimum 95%, Missing); thymus: 86.5724% (minimum 95%, Missing)",0,80,unavailable,1.3,12.2,14.6,"adipose tissue: 14.6 nTPM (manageable, limit 5); esophagus: 12.2 nTPM (protected, limit 2); skin: 9 nTPM (manageable, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000169594,BNC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.323402,-0.302425,-0.0403876
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,13,4.9,11.7,"bone marrow: 13 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000169607,CKAP2L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.7778% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 25.2874% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 74.5763% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.5763% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.6716% (minimum 97%, Baseline (adaptation disabled)); kidney: 97.7778% (minimum 99%, Baseline (adaptation disabled)); liver: 93.6170% (minimum 99%, Baseline (adaptation disabled)); lung: 93.6170% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.3118% (minimum 97%, Baseline (adaptation disabled)); rectum: 67.6923% (minimum 97%, Baseline (adaptation disabled)); retina: 95.6522% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.6170% (minimum 97%, Baseline (adaptation disabled)); skin: 74.5763% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.4815% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.6154% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.4815% (minimum 97%, Baseline (adaptation disabled)); thymus: 27.3292% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.6170% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 86.2745% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,13,4.9,11.7,"bone marrow: 13 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000169607,CKAP2L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.676708,-0.496882,-0.737126
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Uncertain); adrenal gland: 97.7778% (minimum 99%, Missing); bone marrow: 25.2874% (minimum 99%, Missing); cerebral cortex: 91.6667% (minimum 99%, Missing); colon: 74.5763% (minimum 97%, Missing); duodenum: 74.5763% (minimum 99%, Missing); esophagus: 65.6716% (minimum 97%, Missing); kidney: 97.7778% (minimum 99%, Missing); liver: 93.6170% (minimum 99%, Uncertain); lung: 93.6170% (minimum 99%, Missing); lymph node: 47.3118% (minimum 97%, Missing); rectum: 67.6923% (minimum 97%, Missing); retina: 95.6522% (minimum 99%, Missing); salivary gland: 93.6170% (minimum 97%, Missing); skin: 74.5763% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 81.4815% (minimum 99%, Missing); spleen: 84.6154% (minimum 95%, Uncertain); stomach: 81.4815% (minimum 97%, Missing); thymus: 27.3292% (minimum 95%, Missing); thyroid gland: 93.6170% (minimum 95%, Missing); urinary bladder: 86.2745% (minimum 97%, Missing)",0,3,partial,13,4.9,11.7,"bone marrow: 13 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000169607,CKAP2L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.676708,-0.496882,-0.737126
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,0,routine_complete,1.5,1.4,2.3,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169621,APLF,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.6207% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.3846% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.9524% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.2727% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 70.8333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.9524% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.4737% (minimum 99%, Baseline (adaptation disabled)); colon: 62.9630% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.9130% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.8387% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.2727% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.4737% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.3846% (minimum 99%, Baseline (adaptation disabled)); liver: 53.1250% (minimum 99%, Baseline (adaptation disabled)); lung: 65.3846% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.6207% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.9130% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.9524% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 80.9524% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.7143% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.9630% (minimum 99%, Baseline (adaptation disabled)); skin: 42.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.2727% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.7143% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.4737% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.8333% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.7143% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.6207% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.9630% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,1.5,1.4,2.3,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169621,APLF,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.525,-0.421613,-0.45875
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.6207% (minimum 95%, Uncertain); adrenal gland: 65.3846% (minimum 99%, Uncertain); amygdala: 80.9524% (minimum 99%, Missing); basal ganglia: 77.2727% (minimum 99%, Missing); bone marrow: 70.8333% (minimum 99%, Uncertain); cerebral cortex: 80.9524% (minimum 99%, Uncertain); choroid plexus: 89.4737% (minimum 99%, Missing); colon: 62.9630% (minimum 97%, Uncertain); duodenum: 73.9130% (minimum 99%, Uncertain); esophagus: 54.8387% (minimum 97%, Uncertain); heart muscle: 68.0000% (minimum 99%, Uncertain); hippocampal formation: 77.2727% (minimum 99%, Missing); hypothalamus: 89.4737% (minimum 99%, Missing); kidney: 65.3846% (minimum 99%, Uncertain); liver: 53.1250% (minimum 99%, Uncertain); lung: 65.3846% (minimum 99%, Uncertain); lymph node: 58.6207% (minimum 97%, Uncertain); midbrain: 85.0000% (minimum 99%, Missing); pancreas: 73.9130% (minimum 99%, Uncertain); parathyroid gland: 68.0000% (minimum 97%, Uncertain); pituitary gland: 80.9524% (minimum 99%, Missing); rectum: 68.0000% (minimum 97%, Uncertain); retina: 80.9524% (minimum 99%, Missing); salivary gland: 60.7143% (minimum 97%, Uncertain); skeletal muscle: 62.9630% (minimum 99%, Uncertain); skin: 42.5000% (minimum 95%, Uncertain); small intestine: 77.2727% (minimum 99%, Uncertain); smooth muscle: 60.7143% (minimum 99%, Uncertain); spinal cord: 89.4737% (minimum 99%, Missing); spleen: 68.0000% (minimum 95%, Uncertain); stomach: 70.8333% (minimum 97%, Uncertain); thymus: 68.0000% (minimum 95%, Missing); thyroid gland: 60.7143% (minimum 95%, Uncertain); tongue: 58.6207% (minimum 97%, Missing); urinary bladder: 62.9630% (minimum 97%, Uncertain)",0,0,routine_complete,1.5,1.4,2.3,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169621,APLF,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.525,-0.421613,-0.45875
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.7,15.6,26.8,"thymus: 26.8 nTPM (manageable, limit 5); lymph node: 15.6 nTPM (protected, limit 2); bone marrow: 11.7 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); spleen: 5.5 nTPM (manageable, limit 5); esophagus: 4.5 nTPM (protected, limit 2); colon: 4.2 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169679,BUB1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6577% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 71.5328% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 87.5000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.5542% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.7257% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.9899% (minimum 99%, Baseline (adaptation disabled)); liver: 98.3278% (minimum 99%, Baseline (adaptation disabled)); lung: 96.0784% (minimum 99%, Baseline (adaptation disabled)); lymph node: 65.3333% (minimum 97%, Baseline (adaptation disabled)); rectum: 84.2407% (minimum 97%, Baseline (adaptation disabled)); skin: 91.8750% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.6341% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9899% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.2407% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.9297% (minimum 97%, Baseline (adaptation disabled)); thymus: 52.3132% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.4528% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.7,15.6,26.8,"thymus: 26.8 nTPM (manageable, limit 5); lymph node: 15.6 nTPM (protected, limit 2); bone marrow: 11.7 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); spleen: 5.5 nTPM (manageable, limit 5); esophagus: 4.5 nTPM (protected, limit 2); colon: 4.2 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169679,BUB1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.426868,-0.316667,-0.274672
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6577% (minimum 99%, Missing); bone marrow: 71.5328% (minimum 99%, Missing); cerebral cortex: 98.0000% (minimum 99%, Missing); colon: 87.5000% (minimum 97%, Missing); duodenum: 88.5542% (minimum 99%, Missing); esophagus: 86.7257% (minimum 97%, Missing); heart muscle: 98.0000% (minimum 99%, Missing); kidney: 98.9899% (minimum 99%, Missing); liver: 98.3278% (minimum 99%, Missing); lung: 96.0784% (minimum 99%, Missing); lymph node: 65.3333% (minimum 97%, Missing); rectum: 84.2407% (minimum 97%, Missing); skin: 91.8750% (minimum 95%, Missing); small intestine: 89.6341% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spinal cord: 98.9899% (minimum 99%, Missing); spleen: 84.2407% (minimum 95%, Missing); stomach: 93.9297% (minimum 97%, Missing); thymus: 52.3132% (minimum 95%, Missing); urinary bladder: 92.4528% (minimum 97%, Missing)",0,80,unavailable,11.7,15.6,26.8,"thymus: 26.8 nTPM (manageable, limit 5); lymph node: 15.6 nTPM (protected, limit 2); bone marrow: 11.7 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 2); spleen: 5.5 nTPM (manageable, limit 5); esophagus: 4.5 nTPM (protected, limit 2); colon: 4.2 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169679,BUB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.426868,-0.316667,-0.274672
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,4.6,4.1,0.8,"duodenum: 4.6 nTPM (vital, limit 2); rectum: 4.1 nTPM (protected, limit 4); skeletal muscle: 3.8 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 2); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169684,CHRNA5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.9474% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.2245% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.0811% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.9474% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.1707% (minimum 99%, Baseline (adaptation disabled)); colon: 43.4783% (minimum 97%, Baseline (adaptation disabled)); duodenum: 39.4737% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.0811% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.9091% (minimum 99%, Baseline (adaptation disabled)); liver: 90.9091% (minimum 99%, Baseline (adaptation disabled)); lung: 85.7143% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.0811% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.0811% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.5000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.7500% (minimum 99%, Baseline (adaptation disabled)); rectum: 42.2535% (minimum 97%, Baseline (adaptation disabled)); retina: 54.5455% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 81.0811% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 44.1176% (minimum 99%, Baseline (adaptation disabled)); skin: 83.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.6038% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.9091% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.6316% (minimum 97%, Baseline (adaptation disabled)); thymus: 81.0811% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.9091% (minimum 95%, Baseline (adaptation disabled)); tongue: 85.7143% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.8298% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,4.6,4.1,0.8,"duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 2); colon: 3.9 nTPM (protected, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169684,CHRNA5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.160526,-0.547465,-0.595263
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 78.9474% (minimum 90%, Approved); adrenal gland: 61.2245% (minimum 98%, Approved); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 98%, Approved); cerebellum: 81.0811% (minimum 98%, Approved); cerebral cortex: 78.9474% (minimum 99%, Missing); choroid plexus: 73.1707% (minimum 99%, Missing); colon: 43.4783% (minimum 95%, Approved); duodenum: 39.4737% (minimum 98%, Approved); esophagus: 66.6667% (minimum 95%, Approved); heart muscle: 71.4286% (minimum 98%, Approved); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 81.0811% (minimum 99%, Missing); kidney: 90.9091% (minimum 98%, Approved); liver: 90.9091% (minimum 98%, Approved); lung: 85.7143% (minimum 98%, Approved); lymph node: 81.0811% (minimum 95%, Approved); midbrain: 81.0811% (minimum 99%, Missing); pancreas: 62.5000% (minimum 98%, Approved); parathyroid gland: 90.9091% (minimum 95%, Approved); pituitary gland: 93.7500% (minimum 99%, Missing); rectum: 42.2535% (minimum 95%, Approved); retina: 54.5455% (minimum 99%, Missing); salivary gland: 81.0811% (minimum 95%, Approved); skeletal muscle: 44.1176% (minimum 98%, Approved); skin: 83.3333% (minimum 90%, Approved); small intestine: 56.6038% (minimum 98%, Approved); smooth muscle: 60.0000% (minimum 99%, Missing); spinal cord: 83.3333% (minimum 99%, Missing); stomach: 52.6316% (minimum 95%, Approved); thymus: 81.0811% (minimum 95%, Missing); tongue: 85.7143% (minimum 97%, Missing); urinary bladder: 63.8298% (minimum 95%, Approved)",0,2,partial,4.6,4.1,0.8,"duodenum: 4.6 nTPM (vital, limit 2); rectum: 4.1 nTPM (protected, limit 4); skeletal muscle: 3.8 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 2); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169684,CHRNA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.139189,-0.527465,-0.585263
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,7,partial,0,0,0,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),50,not_established,not_triggered,,,ENSG00000169717,ACTRT2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,7,partial,0,0,0,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),50,not_established,not_triggered,,,ENSG00000169717,ACTRT2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,7,partial,0,0,0,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),50,not_established,not_triggered,,,ENSG00000169717,ACTRT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,9,partial,12.3,2.2,1.6,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; thymus; tonsil / germinal center cells,ENSG00000169760,NLGN1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.1935% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.1852% (minimum 99%, Baseline (adaptation disabled)); amygdala: 52.2727% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.4217% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.9362% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 27.2189% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.9661% (minimum 99%, Baseline (adaptation disabled)); colon: 71.8750% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.8333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.7692% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.0137% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.5495% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 51.1111% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.6471% (minimum 99%, Baseline (adaptation disabled)); lung: 93.8776% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.8333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 60.5263% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.4615% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.1961% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.0159% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.7925% (minimum 97%, Baseline (adaptation disabled)); retina: 30.0654% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.8333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.8723% (minimum 99%, Baseline (adaptation disabled)); small intestine: 90.1961% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.6567% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.7143% (minimum 99%, Baseline (adaptation disabled)); stomach: 86.7925% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 85.1852% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.7925% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.6471% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,12.3,2.2,1.6,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; thymus; tonsil / germinal center cells,ENSG00000169760,NLGN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.208065,-0.293529,-0.717811
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 85.1852% (minimum 99%, Missing); amygdala: 52.2727% (minimum 99%, Missing); basal ganglia: 55.4217% (minimum 99%, Missing); cerebellum: 48.9362% (minimum 99%, Missing); cerebral cortex: 27.2189% (minimum 99%, Missing); choroid plexus: 77.9661% (minimum 99%, Missing); colon: 71.8750% (minimum 97%, Missing); duodenum: 95.8333% (minimum 99%, Missing); esophagus: 70.7692% (minimum 80%, Enhanced); heart muscle: 63.0137% (minimum 99%, Missing); hippocampal formation: 50.5495% (minimum 99%, Missing); hypothalamus: 51.1111% (minimum 99%, Missing); kidney: 67.6471% (minimum 99%, Missing); lung: 93.8776% (minimum 95%, Enhanced); lymph node: 95.8333% (minimum 97%, Missing); midbrain: 60.5263% (minimum 99%, Missing); pancreas: 88.4615% (minimum 99%, Missing); parathyroid gland: 90.1961% (minimum 97%, Missing); pituitary gland: 73.0159% (minimum 99%, Missing); retina: 30.0654% (minimum 99%, Missing); salivary gland: 95.8333% (minimum 97%, Missing); small intestine: 90.1961% (minimum 99%, Missing); smooth muscle: 68.6567% (minimum 95%, Enhanced); spinal cord: 65.7143% (minimum 99%, Missing); stomach: 86.7925% (minimum 97%, Missing); thyroid gland: 85.1852% (minimum 95%, Missing); tongue: 86.7925% (minimum 97%, Missing); urinary bladder: 67.6471% (minimum 97%, Missing)",0,9,partial,12.3,2.2,1.6,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; thymus; tonsil / germinal center cells,ENSG00000169760,NLGN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0981481,-0.293529,-0.717811
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,ENSG00000169777,TAS2R1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 97.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.6486% (minimum 99%, Baseline (adaptation disabled)); retina: 97.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,ENSG00000169777,TAS2R1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.0164865,-0.0166667
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 97.3333% (minimum 99%, Missing); hippocampal formation: 98.6486% (minimum 99%, Missing); retina: 97.3333% (minimum 99%, Missing)",0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,ENSG00000169777,TAS2R1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.0164865,-0.0166667
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000169800,RBMY1F,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000169800,RBMY1F,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000169800,RBMY1F,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12,1.3,2.5,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169918,OTUD7A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 78.4314% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); amygdala: 39.6040% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 41.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 25.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 33.8983% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 75.4717% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.0233% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.9565% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.9231% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 33.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 43.0108% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.6327% (minimum 99%, Baseline (adaptation disabled)); liver: 93.0233% (minimum 99%, Baseline (adaptation disabled)); lung: 85.1064% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.0233% (minimum 97%, Baseline (adaptation disabled)); midbrain: 37.3832% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.4717% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.4314% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.7273% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.9091% (minimum 97%, Baseline (adaptation disabled)); retina: 72.7273% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.1064% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 61.5385% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.9565% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 28.9855% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.9565% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.0233% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 80.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.2381% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,12,1.3,2.5,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169918,OTUD7A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.334615,-0.215283,-0.74
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 78.4314% (minimum 95%, Missing); adrenal gland: 88.8889% (minimum 99%, Missing); amygdala: 39.6040% (minimum 99%, Missing); basal ganglia: 41.6667% (minimum 99%, Missing); cerebellum: 25.0000% (minimum 99%, Missing); cerebral cortex: 33.8983% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 75.4717% (minimum 97%, Missing); duodenum: 93.0233% (minimum 99%, Missing); esophagus: 86.9565% (minimum 97%, Missing); heart muscle: 76.9231% (minimum 99%, Missing); hippocampal formation: 33.3333% (minimum 99%, Missing); hypothalamus: 43.0108% (minimum 99%, Missing); kidney: 81.6327% (minimum 99%, Missing); liver: 93.0233% (minimum 99%, Missing); lung: 85.1064% (minimum 99%, Missing); lymph node: 93.0233% (minimum 97%, Missing); midbrain: 37.3832% (minimum 99%, Missing); pancreas: 75.4717% (minimum 99%, Missing); parathyroid gland: 78.4314% (minimum 97%, Missing); pituitary gland: 72.7273% (minimum 99%, Missing); rectum: 90.9091% (minimum 97%, Missing); retina: 72.7273% (minimum 99%, Missing); salivary gland: 85.1064% (minimum 97%, Missing); skeletal muscle: 80.0000% (minimum 99%, Missing); skin: 61.5385% (minimum 95%, Missing); small intestine: 83.3333% (minimum 99%, Missing); smooth muscle: 86.9565% (minimum 99%, Missing); spinal cord: 28.9855% (minimum 99%, Missing); spleen: 86.9565% (minimum 95%, Missing); stomach: 83.3333% (minimum 97%, Missing); thymus: 93.0233% (minimum 95%, Missing); thyroid gland: 80.0000% (minimum 95%, Missing); tongue: 95.2381% (minimum 97%, Missing); urinary bladder: 83.3333% (minimum 97%, Missing)",0,80,unavailable,12,1.3,2.5,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000169918,OTUD7A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.334615,-0.215283,-0.74
True,compatible,,True,True,False,,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000169953,HSFY2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.5577% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0861% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.0861% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5577% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.1564% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000169953,HSFY2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.018436
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.5577% (minimum 99%, Missing); cerebellum: 98.0861% (minimum 99%, Missing); cerebral cortex: 98.0861% (minimum 99%, Missing); hippocampal formation: 98.5577% (minimum 99%, Missing); hypothalamus: 97.1564% (minimum 99%, Missing)",0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000169953,HSFY2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.018436
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,4.9,7.8,3.1,"parathyroid gland: 7.8 nTPM (protected, limit 2); pancreas: 4.9 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000170100,ZNF778,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.4444% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.5294% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.4638% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.9231% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 59.5238% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.2911% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.1250% (minimum 99%, Baseline (adaptation disabled)); colon: 69.4444% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.9672% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.4638% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.4444% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.5294% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.5294% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.7284% (minimum 99%, Baseline (adaptation disabled)); liver: 71.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 70.4225% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.5294% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.5294% (minimum 99%, Baseline (adaptation disabled)); pancreas: 50.5051% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 39.0625% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 73.5294% (minimum 97%, Baseline (adaptation disabled)); retina: 56.8182% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 67.5676% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 57.4713% (minimum 99%, Baseline (adaptation disabled)); skin: 61.7284% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.6269% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.4444% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.4444% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.4932% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.4286% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.5000% (minimum 95%, Baseline (adaptation disabled)); tongue: 54.9451% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.4286% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,4.9,7.8,3.1,"parathyroid gland: 7.8 nTPM (protected, limit 2); pancreas: 4.9 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000170100,ZNF778,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.332716,-0.579375,-0.484949
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Uncertain); adrenal gland: 69.4444% (minimum 99%, Missing); amygdala: 73.5294% (minimum 99%, Missing); basal ganglia: 72.4638% (minimum 99%, Missing); bone marrow: 76.9231% (minimum 99%, Missing); cerebellum: 59.5238% (minimum 99%, Missing); cerebral cortex: 63.2911% (minimum 99%, Missing); choroid plexus: 78.1250% (minimum 99%, Missing); colon: 69.4444% (minimum 97%, Missing); duodenum: 81.9672% (minimum 99%, Missing); esophagus: 72.4638% (minimum 97%, Missing); heart muscle: 69.4444% (minimum 99%, Missing); hippocampal formation: 73.5294% (minimum 99%, Missing); hypothalamus: 73.5294% (minimum 99%, Missing); kidney: 61.7284% (minimum 99%, Missing); liver: 71.4286% (minimum 99%, Missing); lung: 70.4225% (minimum 99%, Missing); lymph node: 73.5294% (minimum 97%, Missing); midbrain: 73.5294% (minimum 99%, Missing); pancreas: 50.5051% (minimum 99%, Missing); parathyroid gland: 39.0625% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 73.5294% (minimum 97%, Missing); retina: 56.8182% (minimum 99%, Missing); salivary gland: 67.5676% (minimum 97%, Missing); skeletal muscle: 57.4713% (minimum 99%, Missing); skin: 61.7284% (minimum 95%, Missing); small intestine: 74.6269% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 69.4444% (minimum 99%, Missing); spleen: 69.4444% (minimum 95%, Missing); stomach: 68.4932% (minimum 97%, Missing); thymus: 71.4286% (minimum 95%, Missing); thyroid gland: 62.5000% (minimum 95%, Missing); tongue: 54.9451% (minimum 97%, Missing); urinary bladder: 71.4286% (minimum 97%, Missing)",0,0,routine_complete,4.9,7.8,3.1,"parathyroid gland: 7.8 nTPM (protected, limit 2); pancreas: 4.9 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000170100,ZNF778,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.332716,-0.579375,-0.484949
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,12.5,2.2,4.3,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 6); cerebellum: 5.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170160,CCDC144A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.2174% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.0297% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.0562% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.4204% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.1343% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.0784% (minimum 99%, Baseline (adaptation disabled)); colon: 85.2174% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.5888% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.9083% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.2883% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.0784% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 89.9083% (minimum 99%, Baseline (adaptation disabled)); lung: 83.7607% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.0323% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.1456% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.7257% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.7257% (minimum 97%, Baseline (adaptation disabled)); retina: 43.9462% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.2174% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.7407% (minimum 99%, Baseline (adaptation disabled)); skin: 77.1654% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.9083% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.7607% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.2308% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.4828% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.5035% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.0909% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.0508% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.9649% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,12.5,2.2,4.3,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); cerebral cortex: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170160,CCDC144A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.254965,-0.153333,-0.550538
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Missing); adrenal gland: 85.2174% (minimum 95%, Enhanced); amygdala: 98.0000% (minimum 99%, Missing); basal ganglia: 97.0297% (minimum 99%, Missing); bone marrow: 55.0562% (minimum 95%, Enhanced); cerebellum: 62.4204% (minimum 99%, Missing); cerebral cortex: 73.1343% (minimum 95%, Enhanced); choroid plexus: 96.0784% (minimum 99%, Missing); duodenum: 91.5888% (minimum 95%, Enhanced); heart muscle: 88.2883% (minimum 95%, Enhanced); hippocampal formation: 96.0784% (minimum 99%, Missing); hypothalamus: 98.0000% (minimum 99%, Missing); kidney: 93.3333% (minimum 99%, Missing); liver: 89.9083% (minimum 95%, Enhanced); lung: 83.7607% (minimum 95%, Enhanced); midbrain: 98.0000% (minimum 99%, Missing); pancreas: 79.0323% (minimum 95%, Enhanced); pituitary gland: 86.7257% (minimum 99%, Missing); retina: 43.9462% (minimum 99%, Missing); skeletal muscle: 90.7407% (minimum 95%, Enhanced); small intestine: 89.9083% (minimum 95%, Enhanced); smooth muscle: 83.7607% (minimum 95%, Enhanced); spinal cord: 94.2308% (minimum 99%, Missing); stomach: 84.4828% (minimum 97%, Missing); thymus: 69.5035% (minimum 95%, Missing); tongue: 83.0508% (minimum 97%, Missing); urinary bladder: 85.9649% (minimum 97%, Missing)",0,3,partial,12.5,2.2,4.3,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 6); cerebellum: 5.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170160,CCDC144A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.254965,-0.139492,-0.550538
True,compatible,,True,True,False,,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000170236,USP50,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.2353% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.7500% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.2353% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.2353% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.2353% (minimum 99%, Baseline (adaptation disabled)); colon: 93.7500% (minimum 97%, Baseline (adaptation disabled)); esophagus: 93.7500% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.7500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.7500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.2353% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.4286% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 88.2353% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.7500% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 78.9474% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.7500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.7500% (minimum 99%, Baseline (adaptation disabled)); skin: 93.7500% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.7500% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.7500% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.2353% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.7500% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000170236,USP50,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.116667,-0.0325,-0.275714
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Missing); adrenal gland: 88.2353% (minimum 99%, Missing); amygdala: 93.7500% (minimum 99%, Missing); basal ganglia: 88.2353% (minimum 99%, Missing); cerebellum: 88.2353% (minimum 99%, Missing); cerebral cortex: 88.2353% (minimum 99%, Missing); colon: 93.7500% (minimum 97%, Missing); esophagus: 93.7500% (minimum 97%, Missing); heart muscle: 93.7500% (minimum 99%, Missing); hippocampal formation: 93.7500% (minimum 99%, Missing); hypothalamus: 88.2353% (minimum 99%, Missing); kidney: 71.4286% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 88.2353% (minimum 99%, Missing); midbrain: 93.7500% (minimum 99%, Missing); pituitary gland: 78.9474% (minimum 99%, Missing); salivary gland: 93.7500% (minimum 97%, Missing); skeletal muscle: 93.7500% (minimum 99%, Missing); skin: 93.7500% (minimum 95%, Missing); small intestine: 93.7500% (minimum 99%, Missing); spinal cord: 93.7500% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); thyroid gland: 88.2353% (minimum 95%, Missing); urinary bladder: 93.7500% (minimum 97%, Missing)",0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000170236,USP50,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.116667,-0.0325,-0.275714
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,28.1,2.5,3.5,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170264,FAM161A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.8182% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.1429% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.0526% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.7368% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.3750% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.9730% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 85.7143% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.1034% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.3750% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.4118% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.1429% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.9730% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.9726% (minimum 99%, Baseline (adaptation disabled)); liver: 88.5246% (minimum 99%, Baseline (adaptation disabled)); lung: 84.3750% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.5246% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.8182% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.0526% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.2308% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 16.1194% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.5246% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.8182% (minimum 99%, Baseline (adaptation disabled)); skin: 90.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.5246% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.1429% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.5246% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.3544% (minimum 97%, Baseline (adaptation disabled)); thymus: 78.2609% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.6742% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.4286% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.3750% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,28.1,2.5,3.5,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170264,FAM161A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.343258,-0.286456,-0.828806
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.7143% (minimum 90%, Approved); adrenal gland: 81.8182% (minimum 98%, Approved); amygdala: 77.1429% (minimum 99%, Missing); basal ganglia: 71.0526% (minimum 99%, Missing); bone marrow: 94.7368% (minimum 98%, Approved); cerebellum: 84.3750% (minimum 98%, Approved); cerebral cortex: 72.9730% (minimum 99%, Missing); choroid plexus: 60.0000% (minimum 99%, Missing); colon: 85.7143% (minimum 95%, Approved); duodenum: 93.1034% (minimum 98%, Approved); esophagus: 84.3750% (minimum 95%, Approved); heart muscle: 79.4118% (minimum 98%, Approved); hippocampal formation: 77.1429% (minimum 99%, Missing); hypothalamus: 72.9730% (minimum 99%, Missing); kidney: 73.9726% (minimum 99%, Missing); liver: 88.5246% (minimum 98%, Approved); lung: 84.3750% (minimum 99%, Missing); lymph node: 88.5246% (minimum 95%, Approved); midbrain: 81.8182% (minimum 99%, Missing); pancreas: 71.0526% (minimum 98%, Approved); parathyroid gland: 75.0000% (minimum 95%, Approved); pituitary gland: 69.2308% (minimum 99%, Missing); rectum: 90.0000% (minimum 95%, Approved); retina: 16.1194% (minimum 99%, Missing); salivary gland: 88.5246% (minimum 95%, Approved); skeletal muscle: 81.8182% (minimum 98%, Approved); small intestine: 88.5246% (minimum 98%, Approved); smooth muscle: 90.0000% (minimum 98%, Approved); spinal cord: 77.1429% (minimum 99%, Missing); spleen: 88.5246% (minimum 90%, Approved); stomach: 68.3544% (minimum 97%, Missing); thymus: 78.2609% (minimum 95%, Missing); thyroid gland: 60.6742% (minimum 90%, Approved); tongue: 96.4286% (minimum 97%, Missing); urinary bladder: 84.3750% (minimum 95%, Approved)",0,4,partial,28.1,2.5,3.5,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170264,FAM161A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.293258,-0.286456,-0.828806
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,1.3,0,0,"retina: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000170279,C7orf33,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"retina: 13.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.3,0,0,"retina: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000170279,C7orf33,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.856667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"retina: 13.3333% (minimum 99%, Missing)",0,80,unavailable,1.3,0,0,"retina: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000170279,C7orf33,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.856667
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,22.2,18.4,7,"skeletal muscle: 22.2 nTPM (vital, limit 6); heart muscle: 19.9 nTPM (vital, limit 6); tongue: 18.4 nTPM (protected, limit 2); kidney: 14.4 nTPM (vital, limit 6); pituitary gland: 12.3 nTPM (vital, limit 1); choroid plexus: 9.7 nTPM (vital, limit 1); adrenal gland: 6.9 nTPM (vital, limit 6); small intestine: 6.9 nTPM (vital, limit 6); duodenum: 6.3 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170469,SPATA24,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.3939% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.9060% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.2938% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.7560% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6878% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.6847% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.6435% (minimum 99%, Baseline (adaptation disabled)); colon: 96.9471% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.7775% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 87.7764% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.4238% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.9060% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.8455% (minimum 99%, Baseline (adaptation disabled)); liver: 96.6847% (minimum 99%, Baseline (adaptation disabled)); lung: 97.9438% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.3302% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.0349% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.5541% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.2531% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.0747% (minimum 99%, Baseline (adaptation disabled)); retina: 95.7775% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.7133% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.5536% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.3939% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.0782% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1448% (minimum 99%, Baseline (adaptation disabled)); tongue: 88.5927% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,22.2,18.4,7,"skeletal muscle: 22.2 nTPM (vital, limit 1); heart muscle: 19.9 nTPM (vital, limit 1); tongue: 18.4 nTPM (protected, limit 2); kidney: 14.4 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); parathyroid gland: 12 nTPM (protected, limit 2); choroid plexus: 9.7 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 2); thyroid gland: 7 nTPM (manageable, limit 5); small intestine: 6.9 nTPM (vital, limit 1); adrenal gland: 6.9 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 2); duodenum: 6.3 nTPM (vital, limit 1); retina: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); spinal cord: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); esophagus: 3.3 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); cerebellum: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170469,SPATA24,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0033022,-0.0840732,-0.124464
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 95.9060% (minimum 99%, Missing); basal ganglia: 96.2938% (minimum 99%, Missing); choroid plexus: 93.6435% (minimum 99%, Missing); heart muscle: 87.7764% (minimum 95%, Enhanced); hippocampal formation: 96.4238% (minimum 99%, Missing); hypothalamus: 95.9060% (minimum 99%, Missing); kidney: 90.8455% (minimum 95%, Enhanced); midbrain: 96.0349% (minimum 99%, Missing); pituitary gland: 92.0747% (minimum 99%, Missing); retina: 95.7775% (minimum 99%, Missing); skeletal muscle: 86.5536% (minimum 95%, Enhanced); spinal cord: 97.1448% (minimum 99%, Missing); tongue: 88.5927% (minimum 97%, Missing)",0,2,partial,22.2,18.4,7,"skeletal muscle: 22.2 nTPM (vital, limit 6); heart muscle: 19.9 nTPM (vital, limit 6); tongue: 18.4 nTPM (protected, limit 2); kidney: 14.4 nTPM (vital, limit 6); pituitary gland: 12.3 nTPM (vital, limit 1); choroid plexus: 9.7 nTPM (vital, limit 1); adrenal gland: 6.9 nTPM (vital, limit 6); small intestine: 6.9 nTPM (vital, limit 6); duodenum: 6.3 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170469,SPATA24,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.029438,-0.0840732,-0.084464
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,6,partial,2.1,2.8,10.2,"skin: 10.2 nTPM (manageable, limit 5)",,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; hair / cells in cuticle; lymph node; skin; spleen; thymus; tonsil,ENSG00000170486,KRT72,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 95.0413% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7124% (minimum 99%, Baseline (adaptation disabled)); duodenum: 93.1174% (minimum 99%, Baseline (adaptation disabled)); lung: 97.0464% (minimum 99%, Baseline (adaptation disabled)); lymph node: 89.1473% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.7124% (minimum 99%, Baseline (adaptation disabled)); skin: 69.2771% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.6335% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.2698% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,2.1,2.8,10.2,"skin: 10.2 nTPM (manageable, limit 5); lymph node: 2.8 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; hair / cells in cuticle; lymph node; skin; spleen; thymus; tonsil,ENSG00000170486,KRT72,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.257229,-0.0785271,-0.0736653
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 93.1174% (minimum 95%, Enhanced); skin: 69.2771% (minimum 95%, Missing); small intestine: 91.6335% (minimum 95%, Enhanced)",0,6,partial,2.1,2.8,10.2,"skin: 10.2 nTPM (manageable, limit 5)",,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; hair / cells in cuticle; lymph node; skin; spleen; thymus; tonsil,ENSG00000170486,KRT72,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.257229,0.03,-0.0336653
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,4.4,2.1,1.4,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,ENSG00000170498,KISS1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.0936% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.2639% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,4.4,2.1,1.4,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); kidney: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,ENSG00000170498,KISS1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0438543,0.0208096,-0.00906412
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.0936% (minimum 99%, Missing); hypothalamus: 98.2639% (minimum 99%, Missing)",0,4,partial,4.4,2.1,1.4,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,ENSG00000170498,KISS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0495585,0.0295585,-0.00906412
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000170516,COX7B2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000170516,COX7B2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0488024,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000170516,COX7B2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0488024,0.03,0.01
True,compatible,,True,True,False,,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000170613,GARIN3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000170613,GARIN3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000170613,GARIN3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,6,5.5,5.9,"bone marrow: 6 nTPM (vital, limit 2); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170627,GTSF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.7828% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,6,5.5,5.9,"bone marrow: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170627,GTSF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0183476,0.000430108,-0.0221716
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.7828% (minimum 98%, Approved)",0,2,partial,6,5.5,5.9,"bone marrow: 6 nTPM (vital, limit 2); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000170627,GTSF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0183476,0.0204301,-0.0121716
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,9,partial,4.7,3.6,0.1,"choroid plexus: 4.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),84,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,ENSG00000170703,TTLL6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.9189% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.3871% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.8610% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.5652% (minimum 99%, Baseline (adaptation disabled)); colon: 87.1429% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.8462% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.3871% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.8610% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.4058% (minimum 99%, Baseline (adaptation disabled)); lung: 96.8254% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.9189% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.8254% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.3871% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.5616% (minimum 97%, Baseline (adaptation disabled)); retina: 98.3871% (minimum 99%, Baseline (adaptation disabled)); small intestine: 91.9598% (minimum 99%, Baseline (adaptation disabled))",0,9,partial,4.7,3.6,0.1,"choroid plexus: 4.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),84,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,ENSG00000170703,TTLL6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0445652,-0.134384,-0.194348
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.9189% (minimum 99%, Missing); basal ganglia: 98.3871% (minimum 99%, Missing); choroid plexus: 79.5652% (minimum 99%, Missing); colon: 87.1429% (minimum 97%, Missing); duodenum: 93.8462% (minimum 99%, Missing); hippocampal formation: 98.3871% (minimum 99%, Missing); hypothalamus: 97.8610% (minimum 99%, Missing); kidney: 88.4058% (minimum 95%, Enhanced); midbrain: 98.9189% (minimum 99%, Missing); pituitary gland: 98.3871% (minimum 99%, Missing); rectum: 83.5616% (minimum 97%, Missing); retina: 98.3871% (minimum 99%, Missing); small intestine: 91.9598% (minimum 99%, Missing)",0,9,partial,4.7,3.6,0.1,"choroid plexus: 4.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),84,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,ENSG00000170703,TTLL6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0445652,-0.134384,-0.194348
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,8.2,12.6,12.5,"lymph node: 12.6 nTPM (protected, limit 2); thymus: 12.5 nTPM (manageable, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); thyroid gland: 6.6 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000170734,POLH,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.2119% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.5714% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.8333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.4262% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 71.5278% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.2963% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.2963% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 71.5278% (minimum 99%, Baseline (adaptation disabled)); colon: 60.5882% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.0680% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.0256% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.6377% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.8333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.5546% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.5946% (minimum 99%, Baseline (adaptation disabled)); liver: 65.6051% (minimum 99%, Baseline (adaptation disabled)); lung: 65.1899% (minimum 99%, Baseline (adaptation disabled)); lymph node: 44.9782% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.8333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.4516% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 74.1007% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.8657% (minimum 99%, Baseline (adaptation disabled)); rectum: 59.8837% (minimum 97%, Baseline (adaptation disabled)); retina: 58.8571% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.5352% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.6757% (minimum 99%, Baseline (adaptation disabled)); skin: 55.6757% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.5479% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.1902% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.4000% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.6051% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.0680% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.1754% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.9467% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.5946% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.1275% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,8.2,12.6,12.5,"lymph node: 12.6 nTPM (protected, limit 2); thymus: 12.5 nTPM (manageable, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); thyroid gland: 6.6 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000170734,POLH,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.498246,-0.520218,-0.433243
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.2119% (minimum 90%, Approved); adrenal gland: 73.5714% (minimum 99%, Missing); amygdala: 85.8333% (minimum 99%, Missing); basal ganglia: 84.4262% (minimum 99%, Missing); bone marrow: 71.5278% (minimum 99%, Missing); cerebellum: 76.2963% (minimum 99%, Missing); cerebral cortex: 76.2963% (minimum 99%, Missing); choroid plexus: 71.5278% (minimum 99%, Missing); colon: 60.5882% (minimum 97%, Missing); duodenum: 70.0680% (minimum 99%, Missing); esophagus: 66.0256% (minimum 97%, Missing); heart muscle: 74.6377% (minimum 99%, Missing); hippocampal formation: 85.8333% (minimum 99%, Missing); hypothalamus: 86.5546% (minimum 99%, Missing); kidney: 69.5946% (minimum 99%, Missing); liver: 65.6051% (minimum 99%, Missing); lung: 65.1899% (minimum 99%, Missing); lymph node: 44.9782% (minimum 97%, Missing); midbrain: 85.8333% (minimum 99%, Missing); pancreas: 66.4516% (minimum 99%, Missing); parathyroid gland: 74.1007% (minimum 97%, Missing); pituitary gland: 76.8657% (minimum 99%, Missing); rectum: 59.8837% (minimum 97%, Missing); retina: 58.8571% (minimum 99%, Missing); salivary gland: 72.5352% (minimum 97%, Missing); skeletal muscle: 55.6757% (minimum 99%, Missing); skin: 55.6757% (minimum 95%, Missing); small intestine: 70.5479% (minimum 99%, Missing); smooth muscle: 63.1902% (minimum 99%, Missing); spinal cord: 82.4000% (minimum 99%, Missing); spleen: 65.6051% (minimum 95%, Missing); stomach: 70.0680% (minimum 97%, Missing); thymus: 45.1754% (minimum 95%, Missing); thyroid gland: 60.9467% (minimum 95%, Missing); tongue: 69.5946% (minimum 97%, Missing); urinary bladder: 69.1275% (minimum 97%, Missing)",0,1,partial,8.2,12.6,12.5,"lymph node: 12.6 nTPM (protected, limit 2); thymus: 12.5 nTPM (manageable, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); thyroid gland: 6.6 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000170734,POLH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.498246,-0.520218,-0.433243
True,compatible,,True,True,False,,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000170748,RBMXL2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000170748,RBMXL2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.05,0.03,0.00714286
True,compatible,,True,True,True,,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000170748,RBMXL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.05,0.03,0.00714286
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170777,TPD52L3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170777,TPD52L3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170777,TPD52L3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170782,OR10A4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170782,OR10A4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170782,OR10A4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,0,0.1,"choroid plexus: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000170788,DYDC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.7952% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.5,0,0.1,"choroid plexus: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000170788,DYDC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0491877,0.03,-0.00204819
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.7952% (minimum 99%, Missing)",0,80,unavailable,1.5,0,0.1,"choroid plexus: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000170788,DYDC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0491877,0.03,-0.00204819
True,compatible,,True,True,False,,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,ENSG00000170820,FSHR,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 90.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,ENSG00000170820,FSHR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0142857,0.03,-0.09
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 90.0000% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,ENSG00000170820,FSHR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0142857,0.03,-0.09
True,compatible,,True,True,False,,0,2,partial,1.4,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000170848,PSG6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.1660% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,1.4,0,0.1,"bone marrow: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000170848,PSG6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.047921,0.03,-0.0183401
True,compatible,,True,True,True,,0,2,partial,1.4,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000170848,PSG6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.00165992
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,70.7,43.7,33.6,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 2); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spleen: 33.6 nTPM (manageable, limit 5); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); pancreas: 27.6 nTPM (vital, limit 1); adipose tissue: 23.7 nTPM (manageable, limit 5); tongue: 23.7 nTPM (protected, limit 2); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); thymus: 17.9 nTPM (manageable, limit 5); heart muscle: 16.5 nTPM (vital, limit 2); lung: 15.9 nTPM (vital, limit 2); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 2); urinary bladder: 15 nTPM (protected, limit 2); retina: 14.6 nTPM (vital, limit 1); salivary gland: 13.5 nTPM (protected, limit 2); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 2); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 2); rectum: 8.8 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000170873,MTSS1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.2784% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 49.5690% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.1868% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.4524% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.7179% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 44.7471% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 59.7920% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.8374% (minimum 99%, Baseline (adaptation disabled)); colon: 76.3274% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.5588% (minimum 99%, Baseline (adaptation disabled)); esophagus: 44.1176% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.6471% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.3028% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.6531% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.6886% (minimum 99%, Baseline (adaptation disabled)); liver: 32.7947% (minimum 99%, Baseline (adaptation disabled)); lung: 68.4524% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.8623% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.8415% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.5556% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.5512% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.3274% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.6767% (minimum 97%, Baseline (adaptation disabled)); retina: 70.2648% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.8750% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 52.5114% (minimum 99%, Baseline (adaptation disabled)); skin: 53.6547% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.7536% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.7671% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 52.1936% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.6608% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.6753% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.8397% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.3960% (minimum 95%, Baseline (adaptation disabled)); tongue: 59.2784% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.6970% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,70.7,43.7,33.6,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 2); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spleen: 33.6 nTPM (manageable, limit 5); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); pancreas: 27.6 nTPM (vital, limit 1); adipose tissue: 23.7 nTPM (manageable, limit 5); tongue: 23.7 nTPM (protected, limit 2); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); thymus: 17.9 nTPM (manageable, limit 5); heart muscle: 16.5 nTPM (vital, limit 1); lung: 15.9 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 2); urinary bladder: 15 nTPM (protected, limit 2); retina: 14.6 nTPM (vital, limit 1); salivary gland: 13.5 nTPM (protected, limit 2); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 2); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000170873,MTSS1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.443392,-0.528824,-0.662053
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.2784% (minimum 95%, Missing); adrenal gland: 49.5690% (minimum 99%, Missing); amygdala: 63.1868% (minimum 99%, Missing); basal ganglia: 68.4524% (minimum 99%, Missing); bone marrow: 73.7179% (minimum 99%, Missing); cerebellum: 44.7471% (minimum 99%, Missing); cerebral cortex: 59.7920% (minimum 99%, Missing); choroid plexus: 76.8374% (minimum 99%, Missing); colon: 76.3274% (minimum 97%, Missing); duodenum: 84.5588% (minimum 99%, Missing); esophagus: 44.1176% (minimum 97%, Missing); heart muscle: 67.6471% (minimum 98%, Approved); hippocampal formation: 63.3028% (minimum 99%, Missing); hypothalamus: 63.6531% (minimum 99%, Missing); kidney: 59.6886% (minimum 99%, Missing); liver: 32.7947% (minimum 99%, Missing); lung: 68.4524% (minimum 98%, Approved); lymph node: 68.8623% (minimum 97%, Missing); midbrain: 62.8415% (minimum 99%, Missing); pancreas: 55.5556% (minimum 99%, Missing); parathyroid gland: 90.5512% (minimum 97%, Missing); pituitary gland: 76.3274% (minimum 99%, Missing); rectum: 79.6767% (minimum 97%, Missing); retina: 70.2648% (minimum 99%, Missing); salivary gland: 71.8750% (minimum 97%, Missing); skeletal muscle: 52.5114% (minimum 99%, Missing); skin: 53.6547% (minimum 95%, Missing); small intestine: 81.7536% (minimum 99%, Missing); smooth muscle: 78.7671% (minimum 98%, Approved); spinal cord: 52.1936% (minimum 99%, Missing); spleen: 50.6608% (minimum 95%, Missing); stomach: 74.6753% (minimum 97%, Missing); thymus: 65.8397% (minimum 95%, Missing); thyroid gland: 85.3960% (minimum 95%, Missing); tongue: 59.2784% (minimum 97%, Missing); urinary bladder: 69.6970% (minimum 97%, Missing)",0,2,partial,70.7,43.7,33.6,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 2); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spleen: 33.6 nTPM (manageable, limit 5); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); pancreas: 27.6 nTPM (vital, limit 1); adipose tissue: 23.7 nTPM (manageable, limit 5); tongue: 23.7 nTPM (protected, limit 2); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); thymus: 17.9 nTPM (manageable, limit 5); heart muscle: 16.5 nTPM (vital, limit 2); lung: 15.9 nTPM (vital, limit 2); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 2); urinary bladder: 15 nTPM (protected, limit 2); retina: 14.6 nTPM (vital, limit 1); salivary gland: 13.5 nTPM (protected, limit 2); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 2); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 2); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 2); rectum: 8.8 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000170873,MTSS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.443392,-0.528824,-0.662053
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,32.1,16.1,12.8,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (manageable, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 2); hippocampal formation: 10 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 4); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 2); urinary bladder: 8.5 nTPM (protected, limit 4); lung: 8.2 nTPM (vital, limit 1); thymus: 8.1 nTPM (manageable, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 4); esophagus: 7.7 nTPM (protected, limit 4); choroid plexus: 7.4 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); colon: 6.9 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 2); rectum: 6.1 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000170903,MSANTD4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.1837% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.2056% (minimum 99%, Baseline (adaptation disabled)); amygdala: 52.2523% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.7170% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 78.9116% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 52.2523% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 42.3358% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 61.0526% (minimum 99%, Baseline (adaptation disabled)); colon: 62.7027% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.4611% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.1036% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 43.4457% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 53.7037% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 54.2056% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.7692% (minimum 99%, Baseline (adaptation disabled)); liver: 63.0435% (minimum 99%, Baseline (adaptation disabled)); lung: 58.5859% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.9763% (minimum 97%, Baseline (adaptation disabled)); midbrain: 52.7273% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.0386% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.4872% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.2381% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.5367% (minimum 97%, Baseline (adaptation disabled)); retina: 26.5446% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.3656% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.4348% (minimum 99%, Baseline (adaptation disabled)); skin: 72.9560% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.4419% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.4562% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 55.5024% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.5859% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.3656% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.8832% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 47.5410% (minimum 95%, Baseline (adaptation disabled)); tongue: 41.8773% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.7114% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,32.1,16.1,12.8,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (manageable, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 2); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 2); lung: 8.2 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); thymus: 8.1 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 2); esophagus: 7.7 nTPM (protected, limit 2); choroid plexus: 7.4 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); colon: 6.9 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000170903,MSANTD4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.47459,-0.551227,-0.724554
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.1837% (minimum 90%, Approved); adrenal gland: 54.2056% (minimum 99%, Missing); amygdala: 52.2523% (minimum 99%, Missing); basal ganglia: 54.7170% (minimum 99%, Missing); bone marrow: 78.9116% (minimum 98%, Approved); cerebellum: 52.2523% (minimum 99%, Missing); cerebral cortex: 42.3358% (minimum 99%, Missing); choroid plexus: 61.0526% (minimum 99%, Missing); colon: 62.7027% (minimum 97%, Missing); duodenum: 69.4611% (minimum 99%, Missing); esophagus: 60.1036% (minimum 95%, Approved); heart muscle: 43.4457% (minimum 99%, Missing); hippocampal formation: 53.7037% (minimum 99%, Missing); hypothalamus: 54.2056% (minimum 99%, Missing); kidney: 55.7692% (minimum 99%, Missing); liver: 63.0435% (minimum 98%, Approved); lung: 58.5859% (minimum 99%, Missing); lymph node: 54.9763% (minimum 95%, Approved); midbrain: 52.7273% (minimum 99%, Missing); pancreas: 56.0386% (minimum 98%, Approved); parathyroid gland: 59.4872% (minimum 95%, Approved); pituitary gland: 55.2381% (minimum 99%, Missing); rectum: 65.5367% (minimum 97%, Missing); retina: 26.5446% (minimum 99%, Missing); salivary gland: 62.3656% (minimum 97%, Missing); skeletal muscle: 50.4348% (minimum 99%, Missing); skin: 72.9560% (minimum 95%, Missing); small intestine: 67.4419% (minimum 99%, Missing); smooth muscle: 53.4562% (minimum 98%, Approved); spinal cord: 55.5024% (minimum 99%, Missing); spleen: 58.5859% (minimum 90%, Approved); stomach: 62.3656% (minimum 97%, Missing); thymus: 58.8832% (minimum 95%, Missing); thyroid gland: 47.5410% (minimum 95%, Missing); tongue: 41.8773% (minimum 97%, Missing); urinary bladder: 57.7114% (minimum 95%, Approved)",0,7,partial,32.1,16.1,12.8,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (manageable, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 2); hippocampal formation: 10 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 4); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 2); urinary bladder: 8.5 nTPM (protected, limit 4); lung: 8.2 nTPM (vital, limit 1); thymus: 8.1 nTPM (manageable, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 4); esophagus: 7.7 nTPM (protected, limit 4); choroid plexus: 7.4 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 2); stomach: 7 nTPM (protected, limit 2); colon: 6.9 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 2); rectum: 6.1 nTPM (protected, limit 2); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000170903,MSANTD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.47459,-0.551227,-0.724554
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170925,TEX13B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170925,TEX13B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170925,TEX13B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,16.4,10.9,8.5,"skeletal muscle: 16.4 nTPM (vital, limit 2); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 2); pancreas: 7.1 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 4); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 2); kidney: 6.1 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 2); midbrain: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); hippocampal formation: 5.6 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 4); esophagus: 5.1 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 2); duodenum: 4.3 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 4); lung: 4.2 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000170946,DNAJC24,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.1481% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 51.5873% (minimum 99%, Baseline (adaptation disabled)); amygdala: 54.1667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.1667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 78.3133% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 47.4453% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.3876% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 71.4286% (minimum 99%, Baseline (adaptation disabled)); colon: 58.5586% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.1852% (minimum 99%, Baseline (adaptation disabled)); esophagus: 56.0345% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 36.5169% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 53.7190% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 52.4194% (minimum 99%, Baseline (adaptation disabled)); kidney: 51.5873% (minimum 99%, Baseline (adaptation disabled)); liver: 52.8455% (minimum 99%, Baseline (adaptation disabled)); lung: 60.7477% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.6183% (minimum 97%, Baseline (adaptation disabled)); midbrain: 53.2787% (minimum 99%, Baseline (adaptation disabled)); pancreas: 47.7941% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.5586% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.0909% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.7477% (minimum 97%, Baseline (adaptation disabled)); retina: 45.4545% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.7190% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 28.3843% (minimum 99%, Baseline (adaptation disabled)); skin: 43.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.1852% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 51.5873% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 52.4194% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.2787% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.0175% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.5217% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.7812% (minimum 95%, Baseline (adaptation disabled)); tongue: 37.3563% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.6218% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,16.4,10.9,8.5,"skeletal muscle: 16.4 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); lymph node: 6.6 nTPM (protected, limit 2); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); kidney: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); hippocampal formation: 5.6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); amygdala: 5.5 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); esophagus: 5.1 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); pituitary gland: 4.5 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); choroid plexus: 2.6 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000170946,DNAJC24,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.516667,-0.596437,-0.706157
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.1481% (minimum 90%, Approved); adrenal gland: 51.5873% (minimum 99%, Missing); amygdala: 54.1667% (minimum 99%, Missing); basal ganglia: 54.1667% (minimum 99%, Missing); bone marrow: 78.3133% (minimum 98%, Approved); cerebellum: 47.4453% (minimum 98%, Approved); cerebral cortex: 50.3876% (minimum 99%, Missing); choroid plexus: 71.4286% (minimum 99%, Missing); colon: 58.5586% (minimum 97%, Missing); duodenum: 60.1852% (minimum 98%, Approved); esophagus: 56.0345% (minimum 97%, Missing); heart muscle: 36.5169% (minimum 99%, Missing); hippocampal formation: 53.7190% (minimum 99%, Missing); hypothalamus: 52.4194% (minimum 99%, Missing); kidney: 51.5873% (minimum 99%, Missing); liver: 52.8455% (minimum 98%, Approved); lung: 60.7477% (minimum 99%, Missing); lymph node: 49.6183% (minimum 95%, Approved); midbrain: 53.2787% (minimum 99%, Missing); pancreas: 47.7941% (minimum 99%, Missing); parathyroid gland: 58.5586% (minimum 97%, Missing); pituitary gland: 59.0909% (minimum 99%, Missing); rectum: 60.7477% (minimum 95%, Approved); retina: 45.4545% (minimum 99%, Missing); salivary gland: 53.7190% (minimum 97%, Missing); skeletal muscle: 28.3843% (minimum 98%, Approved); skin: 43.3333% (minimum 95%, Missing); small intestine: 60.1852% (minimum 98%, Approved); smooth muscle: 51.5873% (minimum 98%, Approved); spinal cord: 52.4194% (minimum 99%, Missing); spleen: 53.2787% (minimum 90%, Approved); stomach: 57.0175% (minimum 97%, Missing); thymus: 56.5217% (minimum 95%, Missing); thyroid gland: 50.7812% (minimum 95%, Missing); tongue: 37.3563% (minimum 97%, Missing); urinary bladder: 54.6218% (minimum 95%, Approved)",0,7,partial,16.4,10.9,8.5,"skeletal muscle: 16.4 nTPM (vital, limit 2); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 2); skin: 8.5 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 2); pancreas: 7.1 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 4); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 2); kidney: 6.1 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 2); midbrain: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); hippocampal formation: 5.6 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 4); esophagus: 5.1 nTPM (protected, limit 2); stomach: 4.9 nTPM (protected, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 2); duodenum: 4.3 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 4); lung: 4.2 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000170946,DNAJC24,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.516667,-0.596437,-0.696157
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,7,partial,0.7,0,0,,kidney / proximal tubules (cell body): Medium (Supported),57,not_established,not_triggered,,,ENSG00000170948,MBD3L1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"pancreas: 97.4074% (minimum 99%, Baseline (adaptation disabled))",0,7,partial,0.7,0,0,,kidney / proximal tubules (cell body): Medium (Supported),57,not_established,not_triggered,,,ENSG00000170948,MBD3L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0159259
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,7,partial,0.7,0,0,,kidney / proximal tubules (cell body): Medium (Supported),57,not_established,not_triggered,,,ENSG00000170948,MBD3L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00407407
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000170950,PGK2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000170950,PGK2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000170950,PGK2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170953,OR8B12,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170953,OR8B12,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000170953,OR8B12,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0.1,0.1,0.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000170965,PLAC1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Wang 2016;Bradley 2020;Gong 2021,,,
True,compatible,,True,True,True,,0,2,partial,0.1,0.1,0.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000170965,PLAC1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Wang 2016;Bradley 2020;Gong 2021,0.0426471,0.02631,0.00630996
True,compatible,,True,True,True,,0,2,partial,0.1,0.1,0.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000170965,PLAC1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,Wang 2016;Bradley 2020;Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000170967,DDI1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000170967,DDI1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000170967,DDI1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000171060,C8orf74,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000171060,C8orf74,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000171060,C8orf74,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,1.7,0.6,0.3,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells,ENSG00000171094,ALK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.5882% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 41.3793% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.3077% (minimum 99%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.3077% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 92.3077% (minimum 99%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.7143% (minimum 97%, Baseline (adaptation disabled)); retina: 63.1579% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.3077% (minimum 97%, Baseline (adaptation disabled)); skin: 92.3077% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.3077% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); stomach: 92.3077% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 80.0000% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,1.7,0.6,0.3,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells,ENSG00000171094,ALK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.15,-0.303333,-0.576207
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 90%, Approved); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 70.5882% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 99%, Missing); cerebral cortex: 41.3793% (minimum 99%, Missing); choroid plexus: 92.3077% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 92.3077% (minimum 98%, Approved); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 60.0000% (minimum 99%, Missing); lung: 92.3077% (minimum 99%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pituitary gland: 50.0000% (minimum 99%, Missing); rectum: 85.7143% (minimum 97%, Missing); retina: 63.1579% (minimum 99%, Missing); salivary gland: 92.3077% (minimum 95%, Approved); skin: 92.3077% (minimum 95%, Missing); small intestine: 85.7143% (minimum 98%, Approved); smooth muscle: 92.3077% (minimum 98%, Approved); spinal cord: 80.0000% (minimum 99%, Missing); stomach: 92.3077% (minimum 95%, Approved); thyroid gland: 80.0000% (minimum 95%, Missing)",0,1,partial,1.7,0.6,0.3,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells,ENSG00000171094,ALK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.15,-0.303333,-0.576207
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,2.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000171102,OBP2B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 98.9691% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,2.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000171102,OBP2B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.15,0.03,-0.000309278
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 98.9691% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing)",0,80,unavailable,0.1,0,2.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000171102,OBP2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.15,0.03,-0.000309278
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,7.6,3.9,7.3,"cerebellum: 7.6 nTPM (vital, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 2); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); stomach: 3.6 nTPM (protected, limit 2); urinary bladder: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000171121,KCNMB3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 48.9130% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 56.2500% (minimum 99%, Baseline (adaptation disabled)); amygdala: 51.1364% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 49.4505% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.5862% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 37.1901% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 40.5405% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.1642% (minimum 99%, Baseline (adaptation disabled)); colon: 53.5714% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.7705% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.2308% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 56.9620% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 45.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 48.3871% (minimum 99%, Baseline (adaptation disabled)); kidney: 49.4505% (minimum 99%, Baseline (adaptation disabled)); liver: 45.4545% (minimum 99%, Baseline (adaptation disabled)); lung: 60.8108% (minimum 99%, Baseline (adaptation disabled)); lymph node: 65.2174% (minimum 97%, Baseline (adaptation disabled)); midbrain: 48.3871% (minimum 99%, Baseline (adaptation disabled)); pancreas: 46.8750% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.5862% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.4416% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.5806% (minimum 97%, Baseline (adaptation disabled)); retina: 61.6438% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.5862% (minimum 99%, Baseline (adaptation disabled)); skin: 66.1765% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.9620% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.2712% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 52.9412% (minimum 99%, Baseline (adaptation disabled)); spleen: 38.1356% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.5556% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.3571% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.2105% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.2353% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.5556% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,7.6,3.9,7.3,"cerebellum: 7.6 nTPM (vital, limit 1); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); urinary bladder: 3.6 nTPM (protected, limit 2); stomach: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); lymph node: 2.4 nTPM (protected, limit 2); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000171121,KCNMB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.568644,-0.434286,-0.618099
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 48.9130% (minimum 90%, Approved); adrenal gland: 56.2500% (minimum 99%, Missing); amygdala: 51.1364% (minimum 99%, Missing); basal ganglia: 49.4505% (minimum 99%, Missing); bone marrow: 77.5862% (minimum 98%, Approved); cerebellum: 37.1901% (minimum 98%, Approved); cerebral cortex: 40.5405% (minimum 98%, Approved); choroid plexus: 67.1642% (minimum 99%, Missing); colon: 53.5714% (minimum 97%, Missing); duodenum: 73.7705% (minimum 99%, Missing); esophagus: 69.2308% (minimum 97%, Missing); heart muscle: 56.9620% (minimum 99%, Missing); hippocampal formation: 45.0000% (minimum 99%, Missing); hypothalamus: 48.3871% (minimum 99%, Missing); kidney: 49.4505% (minimum 99%, Missing); liver: 45.4545% (minimum 99%, Missing); lung: 60.8108% (minimum 98%, Approved); lymph node: 65.2174% (minimum 95%, Approved); midbrain: 48.3871% (minimum 99%, Missing); pancreas: 46.8750% (minimum 99%, Missing); parathyroid gland: 77.5862% (minimum 95%, Approved); pituitary gland: 58.4416% (minimum 99%, Missing); rectum: 72.5806% (minimum 97%, Missing); retina: 61.6438% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 95%, Approved); skeletal muscle: 77.5862% (minimum 98%, Approved); skin: 66.1765% (minimum 95%, Missing); small intestine: 56.9620% (minimum 99%, Missing); smooth muscle: 76.2712% (minimum 98%, Approved); spinal cord: 52.9412% (minimum 99%, Missing); spleen: 38.1356% (minimum 90%, Approved); stomach: 55.5556% (minimum 97%, Missing); thymus: 80.3571% (minimum 95%, Missing); thyroid gland: 59.2105% (minimum 90%, Approved); tongue: 88.2353% (minimum 97%, Missing); urinary bladder: 55.5556% (minimum 97%, Missing)",0,3,partial,7.6,3.9,7.3,"cerebellum: 7.6 nTPM (vital, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 2); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); stomach: 3.6 nTPM (protected, limit 2); urinary bladder: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000171121,KCNMB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.518644,-0.434286,-0.608099
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000171133,OR2K2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 66.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 50.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 28.5714% (minimum 99%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 28.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 20.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000171133,OR2K2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.79
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 66.6667% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 50.0000% (minimum 99%, Missing); midbrain: 28.5714% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing); skeletal muscle: 28.5714% (minimum 99%, Missing); spinal cord: 20.0000% (minimum 99%, Missing)",0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000171133,OR2K2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.79
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,0.1,65.7,0.1,"salivary gland: 65.7 nTPM (protected, limit 12)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,ENSG00000171209,CSN3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 84.2219% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,0.1,65.7,0.1,"salivary gland: 65.7 nTPM (protected, limit 2)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,ENSG00000171209,CSN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.0497149,-0.127781,0.00971494
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,2,partial,0.1,65.7,0.1,"salivary gland: 65.7 nTPM (protected, limit 12)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,ENSG00000171209,CSN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.0497149,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.7,4.5,8.3,"duodenum: 10.7 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); rectum: 4.1 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171320,ESCO2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.8033% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.6957% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.9153% (minimum 99%, Baseline (adaptation disabled)); colon: 60.8696% (minimum 97%, Baseline (adaptation disabled)); duodenum: 34.3558% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.8861% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.5517% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2456% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2456% (minimum 99%, Baseline (adaptation disabled)); liver: 90.3226% (minimum 99%, Baseline (adaptation disabled)); lung: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.4455% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.2456% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.1538% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.9153% (minimum 97%, Baseline (adaptation disabled)); rectum: 57.7320% (minimum 97%, Baseline (adaptation disabled)); retina: 91.8033% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.9153% (minimum 97%, Baseline (adaptation disabled)); skin: 84.8485% (minimum 95%, Baseline (adaptation disabled)); small intestine: 42.4242% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2456% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.8889% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.1358% (minimum 97%, Baseline (adaptation disabled)); thymus: 40.2878% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.9153% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.5517% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.5000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.7,4.5,8.3,"duodenum: 10.7 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); rectum: 4.1 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171320,ESCO2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.547122,-0.415545,-0.646442
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.8033% (minimum 95%, Missing); adrenal gland: 93.3333% (minimum 99%, Missing); bone marrow: 48.6957% (minimum 99%, Missing); cerebral cortex: 94.9153% (minimum 99%, Missing); colon: 60.8696% (minimum 97%, Missing); duodenum: 34.3558% (minimum 99%, Missing); esophagus: 70.8861% (minimum 97%, Missing); heart muscle: 96.5517% (minimum 99%, Missing); hippocampal formation: 98.2456% (minimum 99%, Missing); kidney: 98.2456% (minimum 99%, Missing); liver: 90.3226% (minimum 99%, Missing); lung: 93.3333% (minimum 99%, Missing); lymph node: 55.4455% (minimum 97%, Missing); midbrain: 98.2456% (minimum 99%, Missing); pancreas: 86.1538% (minimum 99%, Missing); parathyroid gland: 94.9153% (minimum 97%, Missing); rectum: 57.7320% (minimum 97%, Missing); retina: 91.8033% (minimum 99%, Missing); salivary gland: 94.9153% (minimum 97%, Missing); skin: 84.8485% (minimum 95%, Missing); small intestine: 42.4242% (minimum 99%, Missing); smooth muscle: 88.8889% (minimum 99%, Missing); spinal cord: 98.2456% (minimum 99%, Missing); spleen: 88.8889% (minimum 95%, Missing); stomach: 69.1358% (minimum 97%, Missing); thymus: 40.2878% (minimum 95%, Missing); thyroid gland: 94.9153% (minimum 95%, Missing); tongue: 96.5517% (minimum 97%, Missing); urinary bladder: 87.5000% (minimum 97%, Missing)",0,80,unavailable,10.7,4.5,8.3,"duodenum: 10.7 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); rectum: 4.1 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171320,ESCO2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.547122,-0.415545,-0.646442
True,compatible,,True,True,False,,0,0,routine_complete,1.9,0.3,3,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000171402,XAGE3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,0,routine_complete,1.9,0.3,3,"liver: 1.9 nTPM (vital, limit 1)",,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000171402,XAGE3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,0.0419203,0.0291861,0.00486764
True,compatible,,True,True,True,,0,0,routine_complete,1.9,0.3,3,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000171402,XAGE3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000171405,XAGE5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000171405,XAGE5,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000171405,XAGE5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,1,partial,0.3,0.2,0.2,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000171478,SPACA5B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 98.7234% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.3,0.2,0.2,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000171478,SPACA5B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.041453,0.021453,-0.00276596
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 98.7234% (minimum 99%, Missing)",0,1,partial,0.3,0.2,0.2,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000171478,SPACA5B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.00276596
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000171481,OR1L3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000171481,OR1L3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000171481,OR1L3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0,21.7,0,"parathyroid gland: 21.7 nTPM (protected, limit 2)",,0,not_established,not_triggered,,,ENSG00000171487,NLRP5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 22.7758% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0,21.7,0,"parathyroid gland: 21.7 nTPM (protected, limit 2)",,0,not_established,not_triggered,,,ENSG00000171487,NLRP5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.742242,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 22.7758% (minimum 97%, Missing)",0,80,unavailable,0,21.7,0,"parathyroid gland: 21.7 nTPM (protected, limit 2)",,0,not_established,not_triggered,,,ENSG00000171487,NLRP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.742242,0.01
True,compatible,,True,True,False,,0,1,partial,0.4,0.2,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000171489,SPACA5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.8571% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.8571% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.5612% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.8571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5612% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.8571% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.1631% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.1631% (minimum 99%, Baseline (adaptation disabled)); retina: 97.1631% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5612% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.4,0.2,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000171489,SPACA5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.0147887,0.0156115,-0.0183688
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.8571% (minimum 99%, Missing); basal ganglia: 97.8571% (minimum 99%, Missing); hippocampal formation: 98.5612% (minimum 99%, Missing); hypothalamus: 97.8571% (minimum 99%, Missing); midbrain: 97.1631% (minimum 99%, Missing); retina: 97.1631% (minimum 99%, Missing); spinal cord: 98.5612% (minimum 99%, Missing)",0,1,partial,0.4,0.2,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000171489,SPACA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.0427536,0.03,-0.0183688
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,42.5,24.3,27,"spinal cord: 42.5 nTPM (vital, limit 1); thymus: 27 nTPM (manageable, limit 5); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 2); salivary gland: 23.8 nTPM (protected, limit 2); spleen: 23.3 nTPM (manageable, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 2); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 2); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (manageable, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 2); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 3.3 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171492,LRRC8D,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.6813% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 32.4675% (minimum 99%, Baseline (adaptation disabled)); amygdala: 45.4545% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 42.2297% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 47.1698% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.3865% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 37.6506% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 61.8812% (minimum 99%, Baseline (adaptation disabled)); colon: 41.9463% (minimum 97%, Baseline (adaptation disabled)); duodenum: 40.3226% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.1891% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.1313% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 33.4225% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 42.6621% (minimum 99%, Baseline (adaptation disabled)); kidney: 33.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 35.4108% (minimum 99%, Baseline (adaptation disabled)); lung: 56.8182% (minimum 99%, Baseline (adaptation disabled)); lymph node: 33.9674% (minimum 97%, Baseline (adaptation disabled)); midbrain: 36.6569% (minimum 99%, Baseline (adaptation disabled)); pancreas: 49.8008% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.8141% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 44.1696% (minimum 99%, Baseline (adaptation disabled)); rectum: 41.5282% (minimum 97%, Baseline (adaptation disabled)); retina: 51.8672% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 34.4353% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.0962% (minimum 99%, Baseline (adaptation disabled)); skin: 69.4444% (minimum 95%, Baseline (adaptation disabled)); small intestine: 41.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.1915% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 22.7273% (minimum 99%, Baseline (adaptation disabled)); spleen: 34.9162% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.7426% (minimum 97%, Baseline (adaptation disabled)); thymus: 31.6456% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 44.8029% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.1139% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.6481% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,42.5,24.3,27,"spinal cord: 42.5 nTPM (vital, limit 1); thymus: 27 nTPM (manageable, limit 5); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 2); salivary gland: 23.8 nTPM (protected, limit 2); spleen: 23.3 nTPM (manageable, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 2); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 2); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (manageable, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 2); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 3.3 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171492,LRRC8D,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.633544,-0.630326,-0.762727
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.6813% (minimum 95%, Missing); adrenal gland: 32.4675% (minimum 99%, Missing); amygdala: 45.4545% (minimum 99%, Missing); basal ganglia: 42.2297% (minimum 99%, Missing); bone marrow: 47.1698% (minimum 99%, Missing); cerebellum: 60.3865% (minimum 99%, Missing); cerebral cortex: 37.6506% (minimum 99%, Missing); choroid plexus: 61.8812% (minimum 99%, Missing); colon: 41.9463% (minimum 97%, Missing); duodenum: 40.3226% (minimum 99%, Missing); esophagus: 62.1891% (minimum 97%, Missing); heart muscle: 63.1313% (minimum 99%, Missing); hippocampal formation: 33.4225% (minimum 99%, Missing); hypothalamus: 42.6621% (minimum 99%, Missing); kidney: 33.3333% (minimum 99%, Missing); liver: 35.4108% (minimum 99%, Missing); lung: 56.8182% (minimum 99%, Missing); lymph node: 33.9674% (minimum 97%, Missing); midbrain: 36.6569% (minimum 99%, Missing); pancreas: 49.8008% (minimum 99%, Missing); parathyroid gland: 62.8141% (minimum 97%, Missing); pituitary gland: 44.1696% (minimum 99%, Missing); rectum: 41.5282% (minimum 97%, Missing); retina: 51.8672% (minimum 99%, Missing); salivary gland: 34.4353% (minimum 97%, Missing); skeletal muscle: 60.0962% (minimum 99%, Missing); skin: 69.4444% (minimum 95%, Missing); small intestine: 41.6667% (minimum 99%, Missing); smooth muscle: 53.1915% (minimum 99%, Missing); spinal cord: 22.7273% (minimum 99%, Missing); spleen: 34.9162% (minimum 95%, Missing); stomach: 52.7426% (minimum 97%, Missing); thymus: 31.6456% (minimum 95%, Missing); thyroid gland: 44.8029% (minimum 95%, Missing); tongue: 79.1139% (minimum 97%, Missing); urinary bladder: 53.6481% (minimum 97%, Missing)",0,80,unavailable,42.5,24.3,27,"spinal cord: 42.5 nTPM (vital, limit 1); thymus: 27 nTPM (manageable, limit 5); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 2); salivary gland: 23.8 nTPM (protected, limit 2); spleen: 23.3 nTPM (manageable, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 2); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 2); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (manageable, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 2); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 2); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 3.3 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171492,LRRC8D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.633544,-0.630326,-0.762727
True,compatible,,True,True,False,,0,1,partial,0,0.1,0,,,55,not_established,not_triggered,,,ENSG00000171495,MROH2B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0.1,0,,,55,not_established,not_triggered,,,ENSG00000171495,MROH2B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0265986,0.01
True,compatible,,True,True,True,,0,1,partial,0,0.1,0,,,55,not_established,not_triggered,,,ENSG00000171495,MROH2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000171505,OR1N1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 33.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000171505,OR1N1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.656667
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 33.3333% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000171505,OR1N1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.656667
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,17,partial,93.1,22.2,7.8,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 2); parathyroid gland: 21.3 nTPM (protected, limit 12); adrenal gland: 18.4 nTPM (vital, limit 6); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 6); heart muscle: 8.3 nTPM (vital, limit 6); skin: 7.8 nTPM (manageable, limit 5); lung: 7.5 nTPM (vital, limit 6); small intestine: 4.6 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / eccrine glands: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),123,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / eccrine glands; skin 1 / hair follicles; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / eccrine glands; spleen; thymus; tonsil,ENSG00000171533,MAP6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.3424% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.1661% (minimum 99%, Baseline (adaptation disabled)); amygdala: 36.9606% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 34.3206% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 47.5845% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 31.6975% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 30.6854% (minimum 99%, Baseline (adaptation disabled)); colon: 63.9610% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.0976% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.5747% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.5996% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 38.1783% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 34.2609% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.4830% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2840% (minimum 99%, Baseline (adaptation disabled)); lung: 84.0085% (minimum 99%, Baseline (adaptation disabled)); midbrain: 45.2354% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.8415% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.9094% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 34.5009% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.0561% (minimum 97%, Baseline (adaptation disabled)); retina: 29.7358% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.0561% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.5248% (minimum 99%, Baseline (adaptation disabled)); skin: 83.4746% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.5455% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.7692% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 47.5271% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.2584% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.2757% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 83.8298% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 85.0972% (minimum 97%, Baseline (adaptation disabled))",0,17,partial,93.1,22.2,7.8,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 2); parathyroid gland: 21.3 nTPM (protected, limit 2); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 2); heart muscle: 8.3 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); thyroid gland: 7.6 nTPM (manageable, limit 5); lung: 7.5 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 2); small intestine: 4.6 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); pancreas: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / eccrine glands: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),123,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / eccrine glands; skin 1 / hair follicles; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / eccrine glands; spleen; thymus; tonsil,ENSG00000171533,MAP6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.115254,-0.33039,-0.692642
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.1661% (minimum 95%, Enhanced); amygdala: 36.9606% (minimum 99%, Missing); basal ganglia: 34.3206% (minimum 99%, Missing); cerebellum: 47.5845% (minimum 99%, Missing); cerebral cortex: 31.6975% (minimum 99%, Missing); choroid plexus: 30.6854% (minimum 99%, Missing); colon: 63.9610% (minimum 97%, Missing); duodenum: 96.0976% (minimum 99%, Missing); heart muscle: 82.5996% (minimum 95%, Enhanced); hippocampal formation: 38.1783% (minimum 99%, Missing); hypothalamus: 34.2609% (minimum 99%, Missing); kidney: 70.4830% (minimum 99%, Missing); lung: 84.0085% (minimum 95%, Enhanced); midbrain: 45.2354% (minimum 99%, Missing); pancreas: 91.8415% (minimum 95%, Enhanced); parathyroid gland: 64.9094% (minimum 80%, Enhanced); pituitary gland: 34.5009% (minimum 99%, Missing); rectum: 92.0561% (minimum 97%, Missing); retina: 29.7358% (minimum 99%, Missing); skin: 83.4746% (minimum 95%, Missing); small intestine: 89.5455% (minimum 99%, Missing); smooth muscle: 75.7692% (minimum 95%, Enhanced); spinal cord: 47.5271% (minimum 99%, Missing); stomach: 79.2757% (minimum 80%, Enhanced)",0,17,partial,93.1,22.2,7.8,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 2); parathyroid gland: 21.3 nTPM (protected, limit 12); adrenal gland: 18.4 nTPM (vital, limit 6); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 6); heart muscle: 8.3 nTPM (vital, limit 6); skin: 7.8 nTPM (manageable, limit 5); lung: 7.5 nTPM (vital, limit 6); small intestine: 4.6 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / eccrine glands: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),123,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / eccrine glands; skin 1 / hair follicles; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / eccrine glands; spleen; thymus; tonsil,ENSG00000171533,MAP6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.115254,-0.33039,-0.692642
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,3,partial,12.9,0,0,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),56,not_established,not_triggered,,,ENSG00000171540,OTP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"basal ganglia: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 1.5267% (minimum 99%, Baseline (adaptation disabled)); lung: 66.6667% (minimum 99%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,12.9,0,0,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),56,not_established,not_triggered,,,ENSG00000171540,OTP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.974733
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"basal ganglia: 50.0000% (minimum 99%, Missing); hypothalamus: 1.5267% (minimum 99%, Missing); lung: 66.6667% (minimum 95%, Enhanced); midbrain: 50.0000% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing)",0,3,partial,12.9,0,0,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),56,not_established,not_triggered,,,ENSG00000171540,OTP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.974733
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.1,0.3,0.2,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000171722,SPATA46,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.6627% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6885% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6885% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.0456% (minimum 99%, Baseline (adaptation disabled)); retina: 92.9012% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.1,0.3,0.2,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000171722,SPATA46,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0433993,0.0201316,-0.0833735
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.6627% (minimum 99%, Missing); cerebellum: 98.6885% (minimum 99%, Missing); liver: 98.6885% (minimum 99%, Missing); pituitary gland: 98.0456% (minimum 99%, Missing); retina: 92.9012% (minimum 99%, Missing)",0,80,unavailable,3.1,0.3,0.2,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000171722,SPATA46,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0433993,0.0201316,-0.0833735
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,5.6,0.8,1.5,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000171757,LRRC34,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.2086% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.6378% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.7133% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.3537% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.8551% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.4127% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.3239% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 96.8750% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.4127% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 91.8519% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.5714% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.5172% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.6565% (minimum 99%, Baseline (adaptation disabled)); liver: 98.4127% (minimum 99%, Baseline (adaptation disabled)); lung: 92.5373% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.9394% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.3239% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 82.1192% (minimum 99%, Baseline (adaptation disabled)); retina: 69.6629% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.6378% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.8750% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.4127% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.7133% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.6565% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.8750% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.2331% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.8750% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.8750% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,5.6,0.8,1.5,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000171757,LRRC34,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0579137,-0.0306061,-0.301111
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.2086% (minimum 90%, Approved); adrenal gland: 97.6378% (minimum 99%, Missing); amygdala: 86.7133% (minimum 99%, Missing); basal ganglia: 84.3537% (minimum 99%, Missing); bone marrow: 89.8551% (minimum 99%, Missing); cerebellum: 98.4127% (minimum 99%, Missing); cerebral cortex: 87.3239% (minimum 99%, Missing); choroid plexus: 68.8889% (minimum 99%, Missing); colon: 96.8750% (minimum 97%, Missing); duodenum: 98.4127% (minimum 99%, Missing); heart muscle: 91.8519% (minimum 98%, Approved); hippocampal formation: 88.5714% (minimum 99%, Missing); hypothalamus: 85.5172% (minimum 99%, Missing); kidney: 94.6565% (minimum 99%, Missing); lung: 92.5373% (minimum 98%, Approved); lymph node: 93.9394% (minimum 95%, Approved); midbrain: 87.3239% (minimum 99%, Missing); pituitary gland: 82.1192% (minimum 99%, Missing); retina: 69.6629% (minimum 99%, Missing); skeletal muscle: 97.6378% (minimum 98%, Approved); small intestine: 96.8750% (minimum 99%, Missing); spinal cord: 86.7133% (minimum 99%, Missing); stomach: 96.8750% (minimum 97%, Missing); thyroid gland: 93.2331% (minimum 95%, Missing); tongue: 96.8750% (minimum 97%, Missing); urinary bladder: 96.8750% (minimum 97%, Missing)",0,6,partial,5.6,0.8,1.5,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000171757,LRRC34,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0176692,-0.0106061,-0.301111
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,17.5,1.6,1.8,"cerebellum: 17.5 nTPM (vital, limit 6); cerebral cortex: 16.3 nTPM (vital, limit 6); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171772,SYCE1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8693% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.5476% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.0175% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.7454% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.8685% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.5604% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.4199% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2882% (minimum 99%, Baseline (adaptation disabled)); liver: 94.6429% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.8275% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.9036% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.2882% (minimum 99%, Baseline (adaptation disabled)); retina: 96.9058% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.8522% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.5130% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,17.5,1.6,1.8,"cerebellum: 17.5 nTPM (vital, limit 1); cerebral cortex: 16.3 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171772,SYCE1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0245403,0.00730496,-0.192546
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 87.5476% (minimum 99%, Missing); basal ganglia: 86.0175% (minimum 99%, Missing); cerebellum: 79.7454% (minimum 95%, Enhanced); cerebral cortex: 80.8685% (minimum 95%, Enhanced); hippocampal formation: 88.5604% (minimum 99%, Missing); hypothalamus: 90.4199% (minimum 99%, Missing); liver: 94.6429% (minimum 95%, Enhanced); midbrain: 95.8275% (minimum 99%, Missing); pancreas: 94.9036% (minimum 95%, Enhanced); pituitary gland: 98.2882% (minimum 99%, Missing); retina: 96.9058% (minimum 99%, Missing); spinal cord: 94.5130% (minimum 99%, Missing)",0,1,partial,17.5,1.6,1.8,"cerebellum: 17.5 nTPM (vital, limit 6); cerebral cortex: 16.3 nTPM (vital, limit 6); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171772,SYCE1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0471056,0.00730496,-0.152546
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2,4,0.7,"salivary gland: 4 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000171790,SLFNL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 98.5333% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0106% (minimum 99%, Baseline (adaptation disabled)); lung: 97.3650% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.9290% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.8652% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.5333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2,4,0.7,"salivary gland: 4 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000171790,SLFNL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0406166,-0.0213479,-0.0163505
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 98.5333% (minimum 99%, Missing); liver: 98.0106% (minimum 99%, Missing); lung: 97.3650% (minimum 99%, Missing); pituitary gland: 98.9290% (minimum 99%, Missing); salivary gland: 94.8652% (minimum 97%, Missing); small intestine: 98.5333% (minimum 99%, Missing)",0,80,unavailable,2,4,0.7,"salivary gland: 4 nTPM (protected, limit 2); lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000171790,SLFNL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0406166,-0.0213479,-0.0163505
True,compatible,,True,True,False,,0,6,partial,0.1,0,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000171794,UTF1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.3051% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.3051% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.3051% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,0.1,0,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000171794,UTF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0330508,0.03,-0.00694915
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.3051% (minimum 99%, Missing); pituitary gland: 98.3051% (minimum 99%, Missing)",0,6,partial,0.1,0,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000171794,UTF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,-0.00694915
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,ENSG00000171804,WDR87,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,ENSG00000171804,WDR87,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0321429,0.03,0.0039759
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,ENSG00000171804,WDR87,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0321429,0.03,0.0039759
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,3.4,3.9,3.1,"parathyroid gland: 3.9 nTPM (protected, limit 2); spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); adrenal gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000171827,ZNF570,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.3590% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.7317% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.6049% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.2353% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.2353% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 78.3784% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.3158% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.7317% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.6049% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.6049% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.2353% (minimum 99%, Baseline (adaptation disabled)); liver: 77.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 74.3590% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.0476% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.2353% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.4521% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.7938% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.0580% (minimum 97%, Baseline (adaptation disabled)); retina: 65.9091% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.6049% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 75.3247% (minimum 99%, Baseline (adaptation disabled)); skin: 77.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.5556% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.0435% (minimum 99%, Baseline (adaptation disabled)); spleen: 71.6049% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.3590% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.6049% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.1685% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.2353% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.3247% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,3.4,3.9,3.1,"parathyroid gland: 3.9 nTPM (protected, limit 2); spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); adrenal gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000171827,ZNF570,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.298315,-0.372062,-0.359565
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.3590% (minimum 95%, Missing); adrenal gland: 70.7317% (minimum 99%, Missing); amygdala: 72.5000% (minimum 99%, Missing); basal ganglia: 71.6049% (minimum 99%, Missing); bone marrow: 72.5000% (minimum 99%, Missing); cerebellum: 68.2353% (minimum 99%, Missing); cerebral cortex: 68.2353% (minimum 99%, Missing); choroid plexus: 77.3333% (minimum 99%, Missing); colon: 78.3784% (minimum 97%, Missing); duodenum: 76.3158% (minimum 99%, Missing); esophagus: 72.5000% (minimum 97%, Missing); heart muscle: 70.7317% (minimum 99%, Missing); hippocampal formation: 71.6049% (minimum 99%, Missing); hypothalamus: 71.6049% (minimum 99%, Missing); kidney: 68.2353% (minimum 99%, Missing); liver: 77.3333% (minimum 99%, Missing); lung: 74.3590% (minimum 99%, Missing); lymph node: 69.0476% (minimum 97%, Missing); midbrain: 68.2353% (minimum 99%, Missing); pancreas: 79.4521% (minimum 99%, Missing); parathyroid gland: 59.7938% (minimum 97%, Missing); pituitary gland: 77.3333% (minimum 99%, Missing); rectum: 84.0580% (minimum 97%, Missing); retina: 65.9091% (minimum 99%, Missing); salivary gland: 71.6049% (minimum 97%, Missing); skeletal muscle: 75.3247% (minimum 99%, Missing); skin: 77.3333% (minimum 95%, Missing); small intestine: 80.5556% (minimum 99%, Missing); smooth muscle: 72.5000% (minimum 99%, Missing); spinal cord: 63.0435% (minimum 99%, Missing); spleen: 71.6049% (minimum 95%, Uncertain); stomach: 74.3590% (minimum 97%, Missing); thymus: 71.6049% (minimum 95%, Missing); thyroid gland: 65.1685% (minimum 95%, Missing); tongue: 68.2353% (minimum 97%, Missing); urinary bladder: 75.3247% (minimum 97%, Missing)",0,2,partial,3.4,3.9,3.1,"parathyroid gland: 3.9 nTPM (protected, limit 2); spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lymph node: 2.6 nTPM (protected, limit 2); adrenal gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000171827,ZNF570,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.298315,-0.372062,-0.359565
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.8,2,2.4,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171847,FAM90A1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 52.6316% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 50.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 86.9565% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 47.6190% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 22.7273% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 83.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.0741% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.5161% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.1429% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 60.6061% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.8235% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.0741% (minimum 99%, Baseline (adaptation disabled)); liver: 95.2381% (minimum 99%, Baseline (adaptation disabled)); lung: 60.6061% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 60.6061% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.0541% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.9565% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 52.6316% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.9091% (minimum 97%, Baseline (adaptation disabled)); retina: 30.7692% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 74.0741% (minimum 99%, Baseline (adaptation disabled)); skin: 47.6190% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.9655% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.9231% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 45.4545% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 83.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.8,2,2.4,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171847,FAM90A1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.495455,-0.47,-0.762727
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Missing); adrenal gland: 52.6316% (minimum 99%, Missing); amygdala: 62.5000% (minimum 99%, Missing); basal ganglia: 50.0000% (minimum 99%, Missing); bone marrow: 86.9565% (minimum 99%, Missing); cerebellum: 47.6190% (minimum 99%, Missing); cerebral cortex: 22.7273% (minimum 99%, Missing); choroid plexus: 80.0000% (minimum 99%, Missing); colon: 83.3333% (minimum 97%, Missing); duodenum: 74.0741% (minimum 99%, Missing); esophagus: 64.5161% (minimum 97%, Missing); heart muscle: 57.1429% (minimum 99%, Missing); hippocampal formation: 60.6061% (minimum 99%, Missing); hypothalamus: 58.8235% (minimum 99%, Missing); kidney: 74.0741% (minimum 99%, Missing); liver: 95.2381% (minimum 99%, Missing); lung: 60.6061% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 60.6061% (minimum 99%, Missing); pancreas: 54.0541% (minimum 99%, Missing); parathyroid gland: 86.9565% (minimum 97%, Missing); pituitary gland: 52.6316% (minimum 99%, Missing); rectum: 90.9091% (minimum 97%, Missing); retina: 30.7692% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing); skeletal muscle: 74.0741% (minimum 99%, Missing); skin: 47.6190% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 68.9655% (minimum 95%, Missing); stomach: 76.9231% (minimum 97%, Missing); thyroid gland: 45.4545% (minimum 95%, Missing); urinary bladder: 83.3333% (minimum 97%, Missing)",0,80,unavailable,6.8,2,2.4,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000171847,FAM90A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.495455,-0.47,-0.762727
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,39.4,1.9,0.2,"choroid plexus: 39.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; thymus; tonsil,ENSG00000171864,PRND,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.5860% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.2857% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,39.4,1.9,0.2,"choroid plexus: 39.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; thymus; tonsil,ENSG00000171864,PRND,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0471014,0.00312588,-0.35414
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.5860% (minimum 99%, Missing)",0,1,partial,39.4,1.9,0.2,"choroid plexus: 39.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; thymus; tonsil,ENSG00000171864,PRND,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0485486,0.0285486,-0.35414
True,compatible,,True,True,False,,0,2,partial,1.1,1,0.1,,,52,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,ENSG00000171872,KLF17,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.1860% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.7805% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7805% (minimum 99%, Baseline (adaptation disabled)); colon: 96.4286% (minimum 97%, Baseline (adaptation disabled)); esophagus: 94.1860% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 98.7805% (minimum 99%, Baseline (adaptation disabled)); lung: 95.2941% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.7805% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.7805% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.0435% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7805% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 89.0110% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,1.1,1,0.1,"smooth muscle: 1.1 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,ENSG00000171872,KLF17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0378049,-0.0798901,-0.109565
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.1860% (minimum 95%, Enhanced); amygdala: 98.7805% (minimum 99%, Missing); hippocampal formation: 98.7805% (minimum 99%, Missing); midbrain: 98.7805% (minimum 99%, Missing); smooth muscle: 88.0435% (minimum 95%, Enhanced); spinal cord: 98.7805% (minimum 99%, Missing)",0,2,partial,1.1,1,0.1,,,52,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,ENSG00000171872,KLF17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.0695652
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.3,0.3,0.8,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000171931,FBXW10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.9583% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.9381% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 87.9630% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.9583% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.1373% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.9381% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.9381% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.9388% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.9388% (minimum 99%, Baseline (adaptation disabled)); liver: 92.2330% (minimum 99%, Baseline (adaptation disabled)); lung: 96.9388% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.9381% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.9583% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.9388% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.9388% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.0594% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.9381% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 92.2330% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.3,0.3,0.8,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000171931,FBXW10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025,-0.0276699,-0.000612245,-0.11037
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.0000% (minimum 99%, Missing); amygdala: 98.9583% (minimum 99%, Missing); basal ganglia: 97.9381% (minimum 99%, Missing); cerebellum: 87.9630% (minimum 99%, Missing); cerebral cortex: 98.9583% (minimum 99%, Missing); choroid plexus: 93.1373% (minimum 99%, Missing); duodenum: 97.9381% (minimum 99%, Missing); hippocampal formation: 97.9381% (minimum 99%, Missing); hypothalamus: 96.9388% (minimum 99%, Missing); kidney: 96.9388% (minimum 99%, Missing); liver: 92.2330% (minimum 99%, Missing); lung: 96.9388% (minimum 99%, Missing); midbrain: 97.9381% (minimum 99%, Missing); pancreas: 98.9583% (minimum 99%, Missing); pituitary gland: 96.9388% (minimum 99%, Missing); salivary gland: 96.9388% (minimum 97%, Missing); skeletal muscle: 94.0594% (minimum 99%, Missing); spinal cord: 97.9381% (minimum 99%, Missing); thyroid gland: 92.2330% (minimum 95%, Missing)",0,80,unavailable,1.3,0.3,0.8,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000171931,FBXW10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Chang 2019;Wang 2016;Loriot 2025,-0.0276699,-0.000612245,-0.11037
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,4.1,0.2,0,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000171956,FOXB1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 85.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 15.3846% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 12.7660% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 31.5789% (minimum 99%, Baseline (adaptation disabled)); stomach: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.1,0.2,0,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000171956,FOXB1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,-0.22,-0.86234
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 85.7143% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); cerebellum: 85.7143% (minimum 99%, Missing); hypothalamus: 15.3846% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 12.7660% (minimum 99%, Missing); skeletal muscle: 85.7143% (minimum 99%, Missing); spinal cord: 31.5789% (minimum 99%, Missing); stomach: 75.0000% (minimum 97%, Missing)",0,80,unavailable,4.1,0.2,0,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000171956,FOXB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,-0.22,-0.86234
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,38.3,20.7,19.6,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 2); spleen: 19.6 nTPM (manageable, limit 5); thyroid gland: 19.1 nTPM (manageable, limit 5); thymus: 18.7 nTPM (manageable, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 2); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 2); tongue: 12.4 nTPM (protected, limit 2); cerebral cortex: 12.3 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 2); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 2); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000171988,JMJD1C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.8383% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.8754% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.9836% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.8785% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.0137% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.6829% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.3478% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.8947% (minimum 99%, Baseline (adaptation disabled)); colon: 68.0982% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.2677% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.2941% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.6122% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.9836% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.9890% (minimum 99%, Baseline (adaptation disabled)); liver: 51.9906% (minimum 99%, Baseline (adaptation disabled)); lung: 60.3261% (minimum 99%, Baseline (adaptation disabled)); lymph node: 51.7483% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.9836% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.7230% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.4823% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.6122% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.0714% (minimum 97%, Baseline (adaptation disabled)); retina: 36.6942% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.7230% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.5517% (minimum 99%, Baseline (adaptation disabled)); skin: 68.0982% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.7789% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.8219% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.9836% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.1100% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.1849% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.2787% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.7530% (minimum 95%, Baseline (adaptation disabled)); tongue: 64.1618% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.4905% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,38.3,20.7,19.6,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 2); spleen: 19.6 nTPM (manageable, limit 5); thyroid gland: 19.1 nTPM (manageable, limit 5); thymus: 18.7 nTPM (manageable, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 2); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 2); tongue: 12.4 nTPM (protected, limit 2); cerebral cortex: 12.3 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 2); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 2); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000171988,JMJD1C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.4189,-0.452517,-0.623058
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.8383% (minimum 95%, Missing); adrenal gland: 65.8754% (minimum 99%, Missing); amygdala: 90.9836% (minimum 99%, Missing); basal ganglia: 89.8785% (minimum 99%, Missing); bone marrow: 38.0137% (minimum 99%, Missing); cerebellum: 67.6829% (minimum 99%, Missing); cerebral cortex: 64.3478% (minimum 99%, Missing); choroid plexus: 77.8947% (minimum 99%, Missing); colon: 68.0982% (minimum 97%, Missing); duodenum: 58.2677% (minimum 99%, Missing); esophagus: 65.2941% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 90.6122% (minimum 99%, Missing); hypothalamus: 90.9836% (minimum 99%, Missing); kidney: 60.9890% (minimum 99%, Missing); liver: 51.9906% (minimum 99%, Missing); lung: 60.3261% (minimum 99%, Missing); lymph node: 51.7483% (minimum 97%, Missing); midbrain: 90.9836% (minimum 99%, Missing); pancreas: 64.7230% (minimum 99%, Missing); parathyroid gland: 52.4823% (minimum 97%, Missing); pituitary gland: 90.6122% (minimum 99%, Missing); rectum: 66.0714% (minimum 97%, Missing); retina: 36.6942% (minimum 99%, Missing); salivary gland: 64.7230% (minimum 97%, Missing); skeletal muscle: 76.5517% (minimum 99%, Missing); skin: 68.0982% (minimum 95%, Missing); small intestine: 55.7789% (minimum 99%, Missing); smooth muscle: 60.8219% (minimum 99%, Missing); spinal cord: 90.9836% (minimum 99%, Missing); spleen: 53.1100% (minimum 95%, Missing); stomach: 62.1849% (minimum 97%, Missing); thymus: 54.2787% (minimum 95%, Missing); thyroid gland: 53.7530% (minimum 95%, Missing); tongue: 64.1618% (minimum 97%, Missing); urinary bladder: 60.4905% (minimum 97%, Missing)",0,1,partial,38.3,20.7,19.6,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 2); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 2); spleen: 19.6 nTPM (manageable, limit 5); thyroid gland: 19.1 nTPM (manageable, limit 5); thymus: 18.7 nTPM (manageable, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 2); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 2); tongue: 12.4 nTPM (protected, limit 2); cerebral cortex: 12.3 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 2); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 2); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000171988,JMJD1C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.4189,-0.452517,-0.623058
True,compatible,,True,True,False,,0,1,partial,0.3,0.2,0.3,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,ENSG00000171989,LDHAL6B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.3,0.2,0.3,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,ENSG00000171989,LDHAL6B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0424623,0.0249622,0.00246231
True,compatible,,True,True,True,,0,1,partial,0.3,0.2,0.3,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,ENSG00000171989,LDHAL6B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00747475
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000172073,TEX37,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000172073,TEX37,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000172073,TEX37,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.1,2.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000172139,SLC9C1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 96.2963% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.7342% (minimum 99%, Baseline (adaptation disabled)); skin: 78.7879% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.1,2.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000172139,SLC9C1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.162121,0.0173418,-0.027037
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 96.2963% (minimum 99%, Missing); pancreas: 98.7342% (minimum 99%, Missing); skin: 78.7879% (minimum 95%, Missing)",0,80,unavailable,0.3,0.1,2.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000172139,SLC9C1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.162121,0.0173418,-0.027037
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,1.1,2.7,3.5,"lymph node: 2.7 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172244,C5orf34,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.6327% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.9091% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.9565% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 78.4314% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.4314% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.5610% (minimum 99%, Baseline (adaptation disabled)); colon: 80.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.9565% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.9565% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.9565% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 90.9091% (minimum 99%, Baseline (adaptation disabled)); lung: 86.9565% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.7015% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.9091% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.0233% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.0233% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.9231% (minimum 97%, Baseline (adaptation disabled)); retina: 88.8889% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.9091% (minimum 99%, Baseline (adaptation disabled)); skin: 75.4717% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.1064% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.4314% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.9091% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.6327% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.1064% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.4314% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.9091% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 74.0741% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,1.1,2.7,3.5,"lymph node: 2.7 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172244,C5orf34,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.416667,-0.372985,-0.205686
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.6327% (minimum 90%, Approved); adrenal gland: 90.9091% (minimum 99%, Missing); amygdala: 86.9565% (minimum 99%, Missing); basal ganglia: 80.0000% (minimum 99%, Missing); bone marrow: 78.4314% (minimum 99%, Missing); cerebellum: 88.8889% (minimum 99%, Missing); cerebral cortex: 78.4314% (minimum 99%, Missing); choroid plexus: 97.5610% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); duodenum: 86.9565% (minimum 99%, Missing); esophagus: 80.0000% (minimum 97%, Missing); heart muscle: 88.8889% (minimum 99%, Missing); hippocampal formation: 86.9565% (minimum 99%, Missing); hypothalamus: 86.9565% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 90.9091% (minimum 99%, Missing); lung: 86.9565% (minimum 99%, Missing); lymph node: 59.7015% (minimum 97%, Missing); midbrain: 90.9091% (minimum 99%, Missing); pancreas: 93.0233% (minimum 99%, Missing); parathyroid gland: 90.9091% (minimum 97%, Missing); pituitary gland: 93.0233% (minimum 99%, Missing); rectum: 76.9231% (minimum 97%, Missing); retina: 88.8889% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 90.9091% (minimum 99%, Missing); skin: 75.4717% (minimum 95%, Missing); small intestine: 85.1064% (minimum 99%, Missing); smooth muscle: 78.4314% (minimum 98%, Approved); spinal cord: 90.9091% (minimum 99%, Missing); spleen: 81.6327% (minimum 90%, Approved); stomach: 85.1064% (minimum 97%, Missing); thymus: 53.3333% (minimum 95%, Missing); thyroid gland: 78.4314% (minimum 95%, Missing); tongue: 90.9091% (minimum 97%, Missing); urinary bladder: 74.0741% (minimum 97%, Missing)",0,3,partial,1.1,2.7,3.5,"lymph node: 2.7 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172244,C5orf34,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.416667,-0.372985,-0.205686
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000172288,CDY1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000172288,CDY1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000172288,CDY1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.4,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000172320,OR5A1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 33.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 33.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 40.0000% (minimum 95%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000172320,OR5A1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.55,-0.303333,-0.656667
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 66.6667% (minimum 99%, Missing); bone marrow: 33.3333% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); pancreas: 66.6667% (minimum 99%, Missing); retina: 33.3333% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 40.0000% (minimum 95%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing)",0,80,unavailable,0.4,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000172320,OR5A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.55,-0.303333,-0.656667
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000172352,CDY1B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000172352,CDY1B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000172352,CDY1B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,19.9,2.4,3.7,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172361,CFAP53,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.4733% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.2687% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.0288% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.2753% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.4733% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.5478% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.8529% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.8182% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 96.0298% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.4811% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.5987% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.9925% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.0298% (minimum 99%, Baseline (adaptation disabled)); retina: 95.7921% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.2362% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.3585% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,19.9,2.4,3.7,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); skeletal muscle: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172361,CFAP53,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00437731,-7.5188e-05,-0.194522
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.2687% (minimum 99%, Missing); basal ganglia: 93.0288% (minimum 99%, Missing); cerebellum: 94.2753% (minimum 95%, Enhanced); choroid plexus: 79.5478% (minimum 99%, Missing); hippocampal formation: 94.8529% (minimum 99%, Missing); hypothalamus: 93.8182% (minimum 99%, Missing); midbrain: 97.4811% (minimum 99%, Missing); pancreas: 98.5987% (minimum 99%, Missing); pituitary gland: 96.0298% (minimum 99%, Missing); retina: 95.7921% (minimum 99%, Missing); spinal cord: 97.3585% (minimum 99%, Missing)",0,6,partial,19.9,2.4,3.7,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172361,CFAP53,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0435815,0.0248586,-0.194522
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000172362,OR5B12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000172362,OR5B12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000172362,OR5B12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000172365,OR5B2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 33.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 33.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000172365,OR5B2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.47,-0.656667
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 33.3333% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); retina: 33.3333% (minimum 99%, Missing)",0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000172365,OR5B2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.47,-0.656667
True,compatible,,True,True,False,,0,2,partial,0.2,0.1,0.4,,,52,not_established,not_triggered,,,ENSG00000172421,EFCAB3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 93.5484% (minimum 95%, Baseline (adaptation disabled)); retina: 96.6667% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.2,0.1,0.4,,,52,not_established,not_triggered,,,ENSG00000172421,EFCAB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.0145161,0.0130508,-0.0233333
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 93.5484% (minimum 95%, Uncertain); retina: 96.6667% (minimum 99%, Missing)",0,2,partial,0.2,0.1,0.4,,,52,not_established,not_triggered,,,ENSG00000172421,EFCAB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.0145161,0.0130508,-0.0233333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,91.4,94.7,33.8,"urinary bladder: 94.7 nTPM (protected, limit 2); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 2); cerebellum: 56.2 nTPM (vital, limit 2); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 2); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 4); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 2); adipose tissue: 33.8 nTPM (manageable, limit 10); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 2); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 2); thyroid gland: 31 nTPM (manageable, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 4); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); spleen: 25.6 nTPM (manageable, limit 10); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 2); liver: 18.5 nTPM (vital, limit 2); skin: 16.8 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 2); salivary gland: 15.6 nTPM (protected, limit 2); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 2); thymus: 11.9 nTPM (manageable, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172465,TCEAL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.3580% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.1583% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.0095% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.7874% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.5282% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.0776% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.4456% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.8949% (minimum 99%, Baseline (adaptation disabled)); colon: 74.1568% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.0109% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.2244% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.4810% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.6706% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.0557% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.4032% (minimum 99%, Baseline (adaptation disabled)); liver: 90.1491% (minimum 99%, Baseline (adaptation disabled)); lung: 85.1181% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.5137% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.3548% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.5767% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.6077% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.6876% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.2668% (minimum 97%, Baseline (adaptation disabled)); retina: 92.2113% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.5630% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.0899% (minimum 99%, Baseline (adaptation disabled)); skin: 90.9726% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.6781% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.9405% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.7649% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.8651% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.2770% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.4327% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.5232% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.9782% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.1288% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,91.4,94.7,33.8,"urinary bladder: 94.7 nTPM (protected, limit 2); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 2); cerebellum: 56.2 nTPM (vital, limit 1); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 1); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 2); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 2); adipose tissue: 33.8 nTPM (manageable, limit 5); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 2); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 1); thyroid gland: 31 nTPM (manageable, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 2); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); spleen: 25.6 nTPM (manageable, limit 5); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 2); salivary gland: 15.6 nTPM (protected, limit 2); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 2); thymus: 11.9 nTPM (manageable, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172465,TCEAL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.11642,-0.328712,-0.340595
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.3580% (minimum 90%, Approved); adrenal gland: 76.1583% (minimum 99%, Missing); amygdala: 80.0095% (minimum 99%, Missing); basal ganglia: 81.7874% (minimum 99%, Missing); bone marrow: 94.5282% (minimum 99%, Missing); cerebellum: 75.0776% (minimum 98%, Approved); cerebral cortex: 75.4456% (minimum 99%, Missing); choroid plexus: 83.8949% (minimum 99%, Missing); colon: 74.1568% (minimum 97%, Missing); duodenum: 92.0109% (minimum 99%, Missing); esophagus: 82.2244% (minimum 97%, Missing); heart muscle: 84.4810% (minimum 98%, Approved); hippocampal formation: 79.6706% (minimum 99%, Missing); hypothalamus: 76.0557% (minimum 99%, Missing); kidney: 87.4032% (minimum 99%, Missing); liver: 90.1491% (minimum 98%, Approved); lung: 85.1181% (minimum 99%, Missing); lymph node: 92.5137% (minimum 97%, Missing); midbrain: 84.3548% (minimum 99%, Missing); pancreas: 89.5767% (minimum 98%, Approved); parathyroid gland: 84.6077% (minimum 95%, Approved); pituitary gland: 83.6876% (minimum 99%, Missing); rectum: 91.2668% (minimum 97%, Missing); retina: 92.2113% (minimum 99%, Missing); salivary gland: 91.5630% (minimum 97%, Missing); skeletal muscle: 76.0899% (minimum 98%, Approved); skin: 90.9726% (minimum 95%, Missing); small intestine: 85.6781% (minimum 99%, Missing); smooth muscle: 64.9405% (minimum 99%, Missing); spinal cord: 85.7649% (minimum 99%, Missing); spleen: 86.8651% (minimum 90%, Approved); stomach: 81.2770% (minimum 95%, Approved); thymus: 93.4327% (minimum 95%, Missing); thyroid gland: 84.5232% (minimum 95%, Missing); tongue: 83.9782% (minimum 97%, Missing); urinary bladder: 64.1288% (minimum 97%, Missing)",0,7,partial,91.4,94.7,33.8,"urinary bladder: 94.7 nTPM (protected, limit 2); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 2); cerebellum: 56.2 nTPM (vital, limit 2); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 2); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 4); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 2); adipose tissue: 33.8 nTPM (manageable, limit 10); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 2); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 2); thyroid gland: 31 nTPM (manageable, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 4); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); spleen: 25.6 nTPM (manageable, limit 10); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 2); liver: 18.5 nTPM (vital, limit 2); skin: 16.8 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 2); salivary gland: 15.6 nTPM (protected, limit 2); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 2); thymus: 11.9 nTPM (manageable, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172465,TCEAL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.104768,-0.328712,-0.340595
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,ENSG00000172468,HSFY1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 97.1698% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.1698% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.1698% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.2617% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.2617% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.6364% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.0952% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.0952% (minimum 99%, Baseline (adaptation disabled)); retina: 98.0952% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,ENSG00000172468,HSFY1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.0203846,-0.0536364
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 97.1698% (minimum 99%, Missing); basal ganglia: 97.1698% (minimum 99%, Missing); cerebellum: 97.1698% (minimum 99%, Missing); cerebral cortex: 96.2617% (minimum 99%, Missing); hippocampal formation: 96.2617% (minimum 99%, Missing); hypothalamus: 93.6364% (minimum 99%, Missing); kidney: 98.0952% (minimum 99%, Missing); midbrain: 98.0952% (minimum 99%, Missing); retina: 98.0952% (minimum 99%, Missing)",0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,ENSG00000172468,HSFY1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.0203846,-0.0536364
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000172519,OR10H5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 25.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 40.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 25.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 40.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000172519,OR10H5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.55,-0.303333,-0.74
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 66.6667% (minimum 99%, Missing); bone marrow: 25.0000% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); lymph node: 66.6667% (minimum 97%, Missing); pancreas: 66.6667% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 40.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 25.0000% (minimum 99%, Missing); skin: 40.0000% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing)",0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000172519,OR10H5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.55,-0.303333,-0.74
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000172538,FAM170B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000172538,FAM170B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000172538,FAM170B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,6.6,4.8,3.3,"cerebellum: 6.6 nTPM (vital, limit 6); lymph node: 4.8 nTPM (protected, limit 2); spinal cord: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); retina: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172671,ZFAND4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.5312% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.8987% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.2857% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.0262% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.2857% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.6154% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.5263% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.5806% (minimum 99%, Baseline (adaptation disabled)); colon: 94.5312% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.7781% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.7784% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.7984% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.0415% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.4358% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.7781% (minimum 99%, Baseline (adaptation disabled)); liver: 90.5237% (minimum 99%, Baseline (adaptation disabled)); lung: 94.2857% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.3212% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.6020% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.7984% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.2865% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.6020% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.5312% (minimum 97%, Baseline (adaptation disabled)); retina: 94.5312% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.2857% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.2857% (minimum 99%, Baseline (adaptation disabled)); skin: 92.1320% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.7781% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.2756% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.8515% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.5567% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.2756% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.1320% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.0317% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.7781% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,6.6,4.8,3.3,"cerebellum: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); spinal cord: 4.1 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); retina: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172671,ZFAND4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0333333,-0.0867883,-0.143846
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.8987% (minimum 95%, Enhanced); amygdala: 94.2857% (minimum 99%, Missing); basal ganglia: 95.0262% (minimum 99%, Missing); bone marrow: 94.2857% (minimum 95%, Enhanced); cerebellum: 84.6154% (minimum 95%, Enhanced); choroid plexus: 97.5806% (minimum 99%, Missing); colon: 94.5312% (minimum 97%, Missing); duodenum: 94.7781% (minimum 99%, Missing); heart muscle: 93.7984% (minimum 95%, Enhanced); hippocampal formation: 94.0415% (minimum 99%, Missing); hypothalamus: 91.4358% (minimum 99%, Missing); kidney: 94.7781% (minimum 99%, Missing); liver: 90.5237% (minimum 95%, Enhanced); lung: 94.2857% (minimum 95%, Enhanced); lymph node: 88.3212% (minimum 97%, Missing); midbrain: 92.6020% (minimum 99%, Missing); pancreas: 93.7984% (minimum 95%, Enhanced); pituitary gland: 92.6020% (minimum 99%, Missing); retina: 94.5312% (minimum 99%, Missing); skeletal muscle: 94.2857% (minimum 95%, Enhanced); small intestine: 94.7781% (minimum 99%, Missing); spinal cord: 89.8515% (minimum 99%, Missing); stomach: 95.2756% (minimum 97%, Missing); thymus: 92.1320% (minimum 95%, Missing); tongue: 96.0317% (minimum 97%, Missing)",0,5,partial,6.6,4.8,3.3,"cerebellum: 6.6 nTPM (vital, limit 6); lymph node: 4.8 nTPM (protected, limit 2); spinal cord: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); retina: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172671,ZFAND4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0286802,-0.0867883,-0.103846
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000172680,MOS,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 87.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.5000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000172680,MOS,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.115
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000172680,MOS,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.115
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; skin; thymus; tonsil,ENSG00000172717,GARIN2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 96.6805% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; skin; thymus; tonsil,ENSG00000172717,GARIN2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0331224,0.0214894,-0.023195
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 96.6805% (minimum 99%, Missing)",0,80,unavailable,0.8,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; skin; thymus; tonsil,ENSG00000172717,GARIN2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0331224,0.0214894,-0.023195
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,11.5,0.3,0.4,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin 2 / epidermal cells; spleen; thymus,ENSG00000172733,PURG,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.5926% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.2857% (minimum 99%, Baseline (adaptation disabled)); amygdala: 34.2466% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 28.0899% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 17.8571% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 31.2500% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.7895% (minimum 99%, Baseline (adaptation disabled)); colon: 89.2857% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.1538% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.2857% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.2069% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 34.2466% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 34.2466% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.2069% (minimum 99%, Baseline (adaptation disabled)); lung: 92.5926% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.5926% (minimum 97%, Baseline (adaptation disabled)); midbrain: 39.6825% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 46.2963% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.1538% (minimum 97%, Baseline (adaptation disabled)); retina: 37.3134% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.5926% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); small intestine: 92.5926% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.1026% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 40.3226% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.2069% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.5926% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.5926% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.1538% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.5926% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,11.5,0.3,0.4,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin 2 / epidermal cells; spleen; thymus,ENSG00000172733,PURG,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.087931,-0.0771429,-0.811429
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 89.2857% (minimum 95%, Enhanced); amygdala: 34.2466% (minimum 99%, Missing); basal ganglia: 28.0899% (minimum 99%, Missing); cerebellum: 17.8571% (minimum 99%, Missing); cerebral cortex: 31.2500% (minimum 99%, Missing); choroid plexus: 65.7895% (minimum 99%, Missing); colon: 89.2857% (minimum 97%, Missing); heart muscle: 86.2069% (minimum 95%, Enhanced); hippocampal formation: 34.2466% (minimum 99%, Missing); hypothalamus: 34.2466% (minimum 99%, Missing); kidney: 86.2069% (minimum 99%, Missing); lung: 92.5926% (minimum 99%, Missing); midbrain: 39.6825% (minimum 99%, Missing); pituitary gland: 46.2963% (minimum 99%, Missing); retina: 37.3134% (minimum 99%, Missing); skeletal muscle: 96.1538% (minimum 99%, Missing); small intestine: 92.5926% (minimum 95%, Enhanced); smooth muscle: 64.1026% (minimum 95%, Enhanced); spinal cord: 40.3226% (minimum 99%, Missing); tongue: 96.1538% (minimum 97%, Missing)",0,5,partial,11.5,0.3,0.4,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin 2 / epidermal cells; spleen; thymus,ENSG00000172733,PURG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0115385,-0.0771429,-0.811429
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,2.1,0.9,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172738,TMEM217,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.5484% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.8636% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.8636% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.3158% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.5652% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.5789% (minimum 99%, Baseline (adaptation disabled)); duodenum: 88.7755% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.2941% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8636% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8636% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.5484% (minimum 99%, Baseline (adaptation disabled)); liver: 90.6250% (minimum 99%, Baseline (adaptation disabled)); lung: 92.5532% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.8636% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.9912% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.8788% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.8636% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 92.5532% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.7755% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.8636% (minimum 99%, Baseline (adaptation disabled)); skin: 90.6250% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.6044% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.6044% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8636% (minimum 99%, Baseline (adaptation disabled)); thymus: 92.5532% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.5532% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 80.5556% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,2.1,0.9,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172738,TMEM217,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.04375,-0.164444,-0.24
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.5484% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); amygdala: 98.8636% (minimum 99%, Missing); basal ganglia: 98.8636% (minimum 99%, Missing); bone marrow: 76.3158% (minimum 99%, Missing); cerebral cortex: 94.5652% (minimum 99%, Missing); choroid plexus: 91.5789% (minimum 99%, Missing); duodenum: 88.7755% (minimum 99%, Missing); esophagus: 85.2941% (minimum 97%, Missing); heart muscle: 96.6667% (minimum 99%, Missing); hippocampal formation: 98.8636% (minimum 99%, Missing); hypothalamus: 98.8636% (minimum 99%, Missing); kidney: 93.5484% (minimum 99%, Missing); liver: 90.6250% (minimum 99%, Missing); lung: 92.5532% (minimum 99%, Missing); lymph node: 96.6667% (minimum 97%, Missing); midbrain: 98.8636% (minimum 99%, Missing); pancreas: 76.9912% (minimum 99%, Missing); parathyroid gland: 87.8788% (minimum 97%, Missing); pituitary gland: 98.8636% (minimum 99%, Missing); rectum: 96.6667% (minimum 97%, Missing); retina: 92.5532% (minimum 99%, Missing); salivary gland: 88.7755% (minimum 97%, Missing); skeletal muscle: 98.8636% (minimum 99%, Missing); skin: 90.6250% (minimum 95%, Missing); small intestine: 95.6044% (minimum 99%, Missing); smooth muscle: 95.6044% (minimum 99%, Missing); spinal cord: 98.8636% (minimum 99%, Missing); thymus: 92.5532% (minimum 95%, Missing); thyroid gland: 92.5532% (minimum 95%, Missing); urinary bladder: 80.5556% (minimum 97%, Missing)",0,80,unavailable,2.9,2.1,0.9,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172738,TMEM217,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.04375,-0.164444,-0.24
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.5,1.6,1.2,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172771,EFCAB12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9381% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.5961% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.1560% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.9596% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.0594% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.4467% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.4068% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.4456% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.4762% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.3636% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.9596% (minimum 99%, Baseline (adaptation disabled)); liver: 94.0594% (minimum 99%, Baseline (adaptation disabled)); lung: 92.2330% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.9381% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.4359% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.2330% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.4444% (minimum 99%, Baseline (adaptation disabled)); retina: 92.6829% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.4456% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4359% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.4467% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 94.0594% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,10.5,1.6,1.2,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172771,EFCAB12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.00940594,-0.0476699,-0.345932
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.9381% (minimum 99%, Missing); amygdala: 93.5961% (minimum 99%, Missing); basal ganglia: 87.1560% (minimum 99%, Missing); bone marrow: 95.9596% (minimum 99%, Missing); cerebellum: 94.0594% (minimum 99%, Missing); cerebral cortex: 96.4467% (minimum 99%, Missing); choroid plexus: 64.4068% (minimum 99%, Missing); heart muscle: 98.4456% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 86.3636% (minimum 99%, Missing); kidney: 95.9596% (minimum 99%, Missing); liver: 94.0594% (minimum 99%, Missing); lung: 92.2330% (minimum 99%, Missing); midbrain: 97.9381% (minimum 99%, Missing); pancreas: 97.4359% (minimum 99%, Missing); parathyroid gland: 92.2330% (minimum 97%, Missing); pituitary gland: 84.4444% (minimum 99%, Missing); retina: 92.6829% (minimum 99%, Missing); small intestine: 98.4456% (minimum 99%, Missing); spinal cord: 97.4359% (minimum 99%, Missing); stomach: 96.4467% (minimum 97%, Missing); thyroid gland: 94.0594% (minimum 95%, Missing)",0,80,unavailable,10.5,1.6,1.2,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000172771,EFCAB12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.00940594,-0.0476699,-0.345932
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,39,37.5,25.1,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 2); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 2); thyroid gland: 25.1 nTPM (manageable, limit 5); urinary bladder: 23.6 nTPM (protected, limit 2); salivary gland: 23.4 nTPM (protected, limit 2); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 2); adipose tissue: 18.4 nTPM (manageable, limit 10); tongue: 17.6 nTPM (protected, limit 2); spleen: 16.5 nTPM (manageable, limit 5); colon: 16.4 nTPM (protected, limit 2); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 2); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 2); midbrain: 13.4 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172785,ZNG1A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.4554% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 39.1459% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.0372% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.8235% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.0372% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.4396% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.6781% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 41.1985% (minimum 99%, Baseline (adaptation disabled)); colon: 57.2917% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.8571% (minimum 99%, Baseline (adaptation disabled)); esophagus: 45.7380% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.3810% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 66.2651% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.5106% (minimum 99%, Baseline (adaptation disabled)); kidney: 36.0656% (minimum 99%, Baseline (adaptation disabled)); liver: 45.0820% (minimum 99%, Baseline (adaptation disabled)); lung: 57.8947% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.1469% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.1469% (minimum 99%, Baseline (adaptation disabled)); pancreas: 42.9688% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 36.9748% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 53.7897% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.9812% (minimum 97%, Baseline (adaptation disabled)); retina: 44.9898% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 48.4581% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 51.0441% (minimum 99%, Baseline (adaptation disabled)); skin: 50.4587% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.6246% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.0888% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.1429% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.1872% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.3229% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 46.7091% (minimum 95%, Baseline (adaptation disabled)); tongue: 55.5556% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 48.2456% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,39,37.5,25.1,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 2); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 2); thyroid gland: 25.1 nTPM (manageable, limit 5); urinary bladder: 23.6 nTPM (protected, limit 2); salivary gland: 23.4 nTPM (protected, limit 2); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 2); adipose tissue: 18.4 nTPM (manageable, limit 5); tongue: 17.6 nTPM (protected, limit 2); spleen: 16.5 nTPM (manageable, limit 5); colon: 16.4 nTPM (protected, limit 2); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 2); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 2); midbrain: 13.4 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172785,ZNG1A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.482909,-0.600252,-0.629344
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.4554% (minimum 90%, Approved); adrenal gland: 39.1459% (minimum 99%, Missing); amygdala: 63.0372% (minimum 99%, Missing); basal ganglia: 58.8235% (minimum 99%, Missing); bone marrow: 63.0372% (minimum 99%, Missing); cerebellum: 60.4396% (minimum 99%, Missing); cerebral cortex: 62.6781% (minimum 99%, Missing); choroid plexus: 41.1985% (minimum 99%, Missing); colon: 57.2917% (minimum 97%, Missing); duodenum: 62.8571% (minimum 99%, Missing); esophagus: 45.7380% (minimum 97%, Missing); heart muscle: 52.3810% (minimum 99%, Missing); hippocampal formation: 66.2651% (minimum 99%, Missing); hypothalamus: 58.5106% (minimum 99%, Missing); kidney: 36.0656% (minimum 99%, Missing); liver: 45.0820% (minimum 99%, Missing); lung: 57.8947% (minimum 99%, Missing); lymph node: 62.1469% (minimum 97%, Missing); midbrain: 62.1469% (minimum 99%, Missing); pancreas: 42.9688% (minimum 99%, Missing); parathyroid gland: 36.9748% (minimum 97%, Missing); pituitary gland: 53.7897% (minimum 99%, Missing); rectum: 58.9812% (minimum 97%, Missing); retina: 44.9898% (minimum 99%, Missing); salivary gland: 48.4581% (minimum 97%, Missing); skeletal muscle: 51.0441% (minimum 99%, Missing); skin: 50.4587% (minimum 95%, Missing); small intestine: 61.6246% (minimum 99%, Missing); smooth muscle: 65.0888% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 57.1429% (minimum 95%, Missing); stomach: 54.1872% (minimum 97%, Missing); thymus: 62.3229% (minimum 95%, Missing); thyroid gland: 46.7091% (minimum 95%, Missing); tongue: 55.5556% (minimum 97%, Missing); urinary bladder: 48.2456% (minimum 97%, Missing)",0,4,partial,39,37.5,25.1,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 2); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 2); thyroid gland: 25.1 nTPM (manageable, limit 5); urinary bladder: 23.6 nTPM (protected, limit 2); salivary gland: 23.4 nTPM (protected, limit 2); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 2); adipose tissue: 18.4 nTPM (manageable, limit 10); tongue: 17.6 nTPM (protected, limit 2); spleen: 16.5 nTPM (manageable, limit 5); colon: 16.4 nTPM (protected, limit 2); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 2); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 2); midbrain: 13.4 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172785,ZNG1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.482909,-0.600252,-0.629344
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,8.9,5.9,9,"thyroid gland: 9 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); adipose tissue: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); tongue: 3.9 nTPM (protected, limit 2); choroid plexus: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172840,PDP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.7477% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.9487% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.6341% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.2500% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.1045% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.6392% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.9608% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 57.6087% (minimum 99%, Baseline (adaptation disabled)); colon: 58.8889% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.5506% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.7143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.4321% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.4321% (minimum 99%, Baseline (adaptation disabled)); kidney: 37.3239% (minimum 99%, Baseline (adaptation disabled)); liver: 38.9706% (minimum 99%, Baseline (adaptation disabled)); lung: 61.6279% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.9487% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.3529% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.6392% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 47.3214% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.6341% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.6087% (minimum 97%, Baseline (adaptation disabled)); retina: 52.4752% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.2273% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 67.9487% (minimum 99%, Baseline (adaptation disabled)); skin: 73.6111% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.0952% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.6027% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.7368% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.6111% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.6341% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.9487% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 37.0629% (minimum 95%, Baseline (adaptation disabled)); tongue: 57.6087% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.6027% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,8.9,5.9,9,"thyroid gland: 9 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); adipose tissue: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); tongue: 3.9 nTPM (protected, limit 2); choroid plexus: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172840,PDP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.579371,-0.496786,-0.616761
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.7477% (minimum 95%, Missing); adrenal gland: 67.9487% (minimum 99%, Missing); amygdala: 64.6341% (minimum 99%, Missing); basal ganglia: 66.2500% (minimum 99%, Missing); bone marrow: 79.1045% (minimum 99%, Missing); cerebellum: 54.6392% (minimum 99%, Missing); cerebral cortex: 51.9608% (minimum 99%, Missing); choroid plexus: 57.6087% (minimum 99%, Missing); colon: 58.8889% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 59.5506% (minimum 97%, Missing); heart muscle: 75.7143% (minimum 99%, Missing); hippocampal formation: 65.4321% (minimum 99%, Missing); hypothalamus: 65.4321% (minimum 99%, Missing); kidney: 37.3239% (minimum 99%, Missing); liver: 38.9706% (minimum 99%, Missing); lung: 61.6279% (minimum 99%, Missing); lymph node: 67.9487% (minimum 97%, Missing); midbrain: 62.3529% (minimum 99%, Missing); pancreas: 54.6392% (minimum 99%, Missing); parathyroid gland: 47.3214% (minimum 97%, Missing); pituitary gland: 64.6341% (minimum 99%, Missing); rectum: 57.6087% (minimum 97%, Missing); retina: 52.4752% (minimum 99%, Missing); salivary gland: 60.2273% (minimum 97%, Missing); skeletal muscle: 67.9487% (minimum 99%, Missing); skin: 73.6111% (minimum 95%, Missing); small intestine: 63.0952% (minimum 99%, Missing); smooth muscle: 72.6027% (minimum 99%, Missing); spinal cord: 69.7368% (minimum 99%, Missing); spleen: 73.6111% (minimum 95%, Missing); stomach: 64.6341% (minimum 97%, Missing); thymus: 67.9487% (minimum 95%, Missing); thyroid gland: 37.0629% (minimum 95%, Missing); tongue: 57.6087% (minimum 97%, Missing); urinary bladder: 72.6027% (minimum 97%, Missing)",0,3,partial,8.9,5.9,9,"thyroid gland: 9 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); adipose tissue: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); tongue: 3.9 nTPM (protected, limit 2); choroid plexus: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 2); esophagus: 3.6 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000172840,PDP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.579371,-0.496786,-0.616761
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000172967,XKR3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.7500% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000172967,XKR3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0375,0.03,-0.0025
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.7500% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000172967,XKR3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0375,0.03,-0.0025
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.6,0,0.1,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000173093,CCDC63,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 91.8033% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 86.5979% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.6,0,0.1,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000173093,CCDC63,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0440828,0.03,-0.124021
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 91.8033% (minimum 99%, Missing); skeletal muscle: 86.5979% (minimum 99%, Missing)",0,80,unavailable,2.6,0,0.1,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000173093,CCDC63,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0440828,0.03,-0.124021
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000173157,ADAMTS20,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"cerebral cortex: 83.3333% (minimum 99%, Baseline (adaptation disabled)); retina: 45.4545% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000173157,ADAMTS20,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.535455
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"cerebral cortex: 83.3333% (minimum 99%, Missing); retina: 45.4545% (minimum 99%, Missing)",0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000173157,ADAMTS20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.535455
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,False,,9,3,partial,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173213,TUBB8B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019;Loriot 2025,,,
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,,9,3,partial,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173213,TUBB8B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019;Loriot 2025,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,,9,3,partial,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173213,TUBB8B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019;Loriot 2025,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.3,3.8,5.8,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173258,ZNF483,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.0435% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.2734% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.4118% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 70.4348% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.8537% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 43.3155% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 51.5924% (minimum 99%, Baseline (adaptation disabled)); colon: 84.3750% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.0112% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.1980% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.8182% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.1429% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.4118% (minimum 99%, Baseline (adaptation disabled)); liver: 91.0112% (minimum 99%, Baseline (adaptation disabled)); lung: 83.5052% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.2632% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.1429% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.6531% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.0672% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.2734% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.0455% (minimum 97%, Baseline (adaptation disabled)); retina: 41.7526% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.2632% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.1702% (minimum 99%, Baseline (adaptation disabled)); skin: 83.5052% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.0110% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.6408% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.3119% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.6408% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.1702% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.0110% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.2734% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.0455% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.1702% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.3,3.8,5.8,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173258,ZNF483,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.367266,-0.289328,-0.572474
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.0435% (minimum 95%, Missing); adrenal gland: 58.2734% (minimum 99%, Missing); amygdala: 81.0000% (minimum 99%, Missing); basal ganglia: 79.4118% (minimum 99%, Missing); bone marrow: 70.4348% (minimum 99%, Missing); cerebellum: 65.8537% (minimum 99%, Missing); cerebral cortex: 43.3155% (minimum 99%, Missing); choroid plexus: 51.5924% (minimum 99%, Missing); colon: 84.3750% (minimum 97%, Missing); duodenum: 90.0000% (minimum 99%, Missing); esophagus: 91.0112% (minimum 97%, Missing); heart muscle: 80.1980% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 77.1429% (minimum 99%, Missing); kidney: 79.4118% (minimum 99%, Missing); liver: 91.0112% (minimum 99%, Missing); lung: 83.5052% (minimum 99%, Missing); lymph node: 85.2632% (minimum 97%, Missing); midbrain: 77.1429% (minimum 99%, Missing); pancreas: 82.6531% (minimum 99%, Missing); parathyroid gland: 68.0672% (minimum 97%, Missing); pituitary gland: 58.2734% (minimum 99%, Missing); rectum: 92.0455% (minimum 97%, Missing); retina: 41.7526% (minimum 99%, Missing); salivary gland: 85.2632% (minimum 97%, Missing); skeletal muscle: 86.1702% (minimum 99%, Missing); skin: 83.5052% (minimum 95%, Missing); small intestine: 89.0110% (minimum 99%, Missing); smooth muscle: 78.6408% (minimum 99%, Missing); spinal cord: 74.3119% (minimum 99%, Missing); spleen: 78.6408% (minimum 95%, Missing); stomach: 86.1702% (minimum 97%, Missing); thymus: 89.0110% (minimum 95%, Missing); thyroid gland: 58.2734% (minimum 95%, Missing); tongue: 92.0455% (minimum 97%, Missing); urinary bladder: 86.1702% (minimum 97%, Missing)",0,80,unavailable,11.3,3.8,5.8,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173258,ZNF483,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.367266,-0.289328,-0.572474
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.4,0.4,0.8,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000173261,PLAC8L1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.3516% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.2105% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.2292% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.9497% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.2292% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8950% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.3516% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.2680% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.2292% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.8142% (minimum 99%, Baseline (adaptation disabled)); liver: 95.2128% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8950% (minimum 99%, Baseline (adaptation disabled)); midbrain: 92.2680% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.2826% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.2366% (minimum 99%, Baseline (adaptation disabled)); retina: 96.2366% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.8142% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.3516% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.1773% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.4,0.4,0.8,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000173261,PLAC8L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00721925,0.00814208,-0.108227
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.3516% (minimum 99%, Missing); amygdala: 94.2105% (minimum 99%, Missing); basal ganglia: 93.2292% (minimum 99%, Missing); cerebellum: 89.9497% (minimum 99%, Missing); cerebral cortex: 93.2292% (minimum 99%, Missing); choroid plexus: 98.8950% (minimum 99%, Missing); heart muscle: 98.3516% (minimum 99%, Missing); hippocampal formation: 92.2680% (minimum 99%, Missing); hypothalamus: 93.2292% (minimum 99%, Missing); kidney: 97.8142% (minimum 99%, Missing); liver: 95.2128% (minimum 99%, Missing); lung: 98.8950% (minimum 99%, Missing); midbrain: 92.2680% (minimum 99%, Missing); pancreas: 97.2826% (minimum 99%, Missing); pituitary gland: 96.2366% (minimum 99%, Missing); retina: 96.2366% (minimum 99%, Missing); skeletal muscle: 97.8142% (minimum 99%, Missing); small intestine: 98.3516% (minimum 99%, Missing); spinal cord: 88.1773% (minimum 99%, Missing)",0,80,unavailable,2.4,0.4,0.8,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,ENSG00000173261,PLAC8L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00721925,0.00814208,-0.108227
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,9,partial,6.4,1.5,1.8,"pancreas: 6.4 nTPM (vital, limit 3); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173262,SLC2A14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.5218% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.7570% (minimum 99%, Baseline (adaptation disabled)); liver: 96.4763% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.5408% (minimum 99%, Baseline (adaptation disabled)); retina: 98.3891% (minimum 99%, Baseline (adaptation disabled))",0,9,partial,6.4,1.5,1.8,"pancreas: 6.4 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173262,SLC2A14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021;Loriot 2025,0.0278325,0.0114586,-0.0645921
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.5218% (minimum 99%, Missing); bone marrow: 92.7570% (minimum 99%, Missing); liver: 96.4763% (minimum 97%, Supported); pancreas: 92.5408% (minimum 97%, Supported); retina: 98.3891% (minimum 99%, Missing)",0,9,partial,6.4,1.5,1.8,"pancreas: 6.4 nTPM (vital, limit 3); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173262,SLC2A14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021;Loriot 2025,0.0474874,0.03,-0.0624299
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000173335,CST9,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 95.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000173335,CST9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.04
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 95.0000% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000173335,CST9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.04
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000173389,IQCF1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000173389,IQCF1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000173389,IQCF1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0.4,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000173401,GLIPR1L1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.7500% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7500% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.4,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000173401,GLIPR1L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0344237,0.0205956,-0.0025
True,compatible,,True,True,True,,0,2,partial,0.4,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000173401,GLIPR1L1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0268454,0.000595611
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,1.4,1.1,3.1,"choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173421,IHO1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.2361% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.8339% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.8462% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.1852% (minimum 99%, Baseline (adaptation disabled)); colon: 95.8955% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.8955% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8462% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0916% (minimum 99%, Baseline (adaptation disabled)); retina: 97.3485% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.9811% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8462% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.6165% (minimum 99%, Baseline (adaptation disabled)); tongue: 96.9811% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.9811% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,1.4,1.1,3.1,"adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173421,IHO1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0576389,-0.0110448,-0.0416605
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.2361% (minimum 90%, Approved); adrenal gland: 94.8339% (minimum 98%, Approved); choroid plexus: 95.1852% (minimum 99%, Missing); heart muscle: 95.8955% (minimum 98%, Approved); retina: 97.3485% (minimum 99%, Missing); skeletal muscle: 96.9811% (minimum 98%, Approved); smooth muscle: 96.6165% (minimum 98%, Approved); tongue: 96.9811% (minimum 97%, Missing)",0,3,partial,1.4,1.1,3.1,"choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173421,IHO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00763889,-0.000188679,-0.0381481
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.2,53.2,0.2,"salivary gland: 53.2 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000173431,RNASE8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0.2,53.2,0.2,"salivary gland: 53.2 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000173431,RNASE8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0.2,53.2,0.2,"salivary gland: 53.2 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000173431,RNASE8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,25.2,27.2,15.5,"urinary bladder: 27.2 nTPM (protected, limit 4); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (manageable, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 2); esophagus: 6.4 nTPM (protected, limit 2); stomach: 6.2 nTPM (protected, limit 2); spinal cord: 5.6 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); midbrain: 4.4 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 2); liver: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); pancreas: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173451,THAP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.1722% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 41.1215% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.7339% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.1060% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.6584% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.2222% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.6154% (minimum 99%, Baseline (adaptation disabled)); colon: 81.4815% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.1905% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.8761% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.1060% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.2222% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.5217% (minimum 99%, Baseline (adaptation disabled)); liver: 80.3653% (minimum 99%, Baseline (adaptation disabled)); lung: 79.2793% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.5652% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.6291% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.2105% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.9718% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.1905% (minimum 97%, Baseline (adaptation disabled)); retina: 61.7544% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.2793% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.5714% (minimum 99%, Baseline (adaptation disabled)); skin: 76.1905% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.1060% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.3653% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.8621% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.8761% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.9496% (minimum 97%, Baseline (adaptation disabled)); thymus: 76.8559% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 80.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.5217% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 39.2857% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,25.2,27.2,15.5,"urinary bladder: 27.2 nTPM (protected, limit 2); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (manageable, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); stomach: 6.2 nTPM (protected, limit 2); spinal cord: 5.6 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); midbrain: 4.4 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); pancreas: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173451,THAP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.418278,-0.577143,-0.578785
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.1722% (minimum 95%, Missing); adrenal gland: 41.1215% (minimum 99%, Missing); amygdala: 80.7339% (minimum 99%, Missing); basal ganglia: 81.1060% (minimum 99%, Missing); bone marrow: 54.6584% (minimum 99%, Missing); cerebellum: 73.3333% (minimum 98%, Approved); cerebral cortex: 78.2222% (minimum 99%, Missing); choroid plexus: 84.6154% (minimum 99%, Missing); colon: 81.4815% (minimum 97%, Missing); duodenum: 76.1905% (minimum 99%, Missing); esophagus: 73.3333% (minimum 97%, Missing); heart muscle: 77.8761% (minimum 99%, Missing); hippocampal formation: 81.1060% (minimum 99%, Missing); hypothalamus: 78.2222% (minimum 99%, Missing); kidney: 76.5217% (minimum 99%, Missing); liver: 80.3653% (minimum 99%, Missing); lung: 79.2793% (minimum 99%, Missing); lymph node: 69.5652% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 82.6291% (minimum 99%, Missing); parathyroid gland: 84.2105% (minimum 97%, Missing); pituitary gland: 61.9718% (minimum 99%, Missing); rectum: 76.1905% (minimum 97%, Missing); retina: 61.7544% (minimum 99%, Missing); salivary gland: 79.2793% (minimum 97%, Missing); skeletal muscle: 78.5714% (minimum 99%, Missing); skin: 76.1905% (minimum 95%, Missing); small intestine: 81.1060% (minimum 99%, Missing); smooth muscle: 80.3653% (minimum 98%, Approved); spinal cord: 75.8621% (minimum 99%, Missing); spleen: 77.8761% (minimum 90%, Approved); stomach: 73.9496% (minimum 97%, Missing); thymus: 76.8559% (minimum 95%, Missing); thyroid gland: 80.0000% (minimum 95%, Missing); tongue: 76.5217% (minimum 97%, Missing); urinary bladder: 39.2857% (minimum 95%, Approved)",0,5,partial,25.2,27.2,15.5,"urinary bladder: 27.2 nTPM (protected, limit 4); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (manageable, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 2); esophagus: 6.4 nTPM (protected, limit 2); stomach: 6.2 nTPM (protected, limit 2); spinal cord: 5.6 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 2); midbrain: 4.4 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 2); liver: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); pancreas: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173451,THAP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.418278,-0.557143,-0.578785
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000173464,RNASE11,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000173464,RNASE11,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.0098446
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000173464,RNASE11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.0098446
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,8.5,4.6,1.1,"choroid plexus: 8.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,ENSG00000173557,CIMIP2C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.9925% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.2687% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.8506% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.2187% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.4733% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.2687% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.8149% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.2687% (minimum 99%, Baseline (adaptation disabled)); lung: 98.4733% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.9925% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.3585% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.3585% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.1408% (minimum 97%, Baseline (adaptation disabled)); spinal cord: 98.4733% (minimum 99%, Baseline (adaptation disabled)); stomach: 84.8684% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,8.5,4.6,1.1,"choroid plexus: 8.5 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); hypothalamus: 2.3 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,ENSG00000173557,CIMIP2C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00910781,-0.121316,-0.237813
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.9925% (minimum 99%, Missing); basal ganglia: 96.2687% (minimum 99%, Missing); choroid plexus: 75.2187% (minimum 99%, Missing); hippocampal formation: 96.2687% (minimum 99%, Missing); hypothalamus: 91.8149% (minimum 99%, Missing); midbrain: 96.9925% (minimum 99%, Missing); pituitary gland: 97.3585% (minimum 99%, Missing); spinal cord: 98.4733% (minimum 99%, Missing)",0,4,partial,8.5,4.6,1.1,"choroid plexus: 8.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,ENSG00000173557,CIMIP2C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.00727273,-0.237813
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,7.2,2.8,10.9,"thymus: 10.9 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000173611,SCAI,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.4103% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 46.8085% (minimum 99%, Baseline (adaptation disabled)); amygdala: 48.8889% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 39.2857% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 44.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 41.5094% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 24.1758% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 50.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 55.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.8571% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.8571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 48.8889% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 45.8333% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.1111% (minimum 99%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 99%, Baseline (adaptation disabled)); lung: 41.5094% (minimum 99%, Baseline (adaptation disabled)); lymph node: 44.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.1111% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.4103% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.4595% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.8947% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.4103% (minimum 97%, Baseline (adaptation disabled)); retina: 23.4043% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.8571% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 57.8947% (minimum 99%, Baseline (adaptation disabled)); skin: 48.8889% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.4595% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.8571% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.6585% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.4595% (minimum 97%, Baseline (adaptation disabled)); thymus: 16.7939% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 70.9677% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.4595% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,7.2,2.8,10.9,"thymus: 10.9 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000173611,SCAI,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.782061,-0.53,-0.755957
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.4103% (minimum 95%, Missing); adrenal gland: 46.8085% (minimum 99%, Missing); amygdala: 48.8889% (minimum 99%, Missing); basal ganglia: 39.2857% (minimum 99%, Missing); bone marrow: 44.0000% (minimum 99%, Missing); cerebellum: 41.5094% (minimum 99%, Missing); cerebral cortex: 24.1758% (minimum 99%, Missing); choroid plexus: 50.0000% (minimum 99%, Missing); colon: 55.0000% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 62.8571% (minimum 97%, Missing); heart muscle: 62.8571% (minimum 99%, Missing); hippocampal formation: 48.8889% (minimum 99%, Missing); hypothalamus: 45.8333% (minimum 99%, Missing); kidney: 61.1111% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Missing); lung: 41.5094% (minimum 99%, Missing); lymph node: 44.0000% (minimum 97%, Missing); midbrain: 61.1111% (minimum 99%, Missing); pancreas: 56.4103% (minimum 99%, Missing); parathyroid gland: 59.4595% (minimum 97%, Missing); pituitary gland: 57.8947% (minimum 99%, Missing); rectum: 56.4103% (minimum 97%, Missing); retina: 23.4043% (minimum 99%, Missing); salivary gland: 62.8571% (minimum 97%, Missing); skeletal muscle: 57.8947% (minimum 99%, Missing); skin: 48.8889% (minimum 95%, Missing); small intestine: 59.4595% (minimum 99%, Missing); smooth muscle: 62.8571% (minimum 99%, Missing); spinal cord: 62.8571% (minimum 99%, Missing); spleen: 53.6585% (minimum 95%, Missing); stomach: 59.4595% (minimum 97%, Missing); thymus: 16.7939% (minimum 95%, Missing); thyroid gland: 55.0000% (minimum 95%, Missing); tongue: 70.9677% (minimum 97%, Missing); urinary bladder: 59.4595% (minimum 97%, Missing)",0,4,partial,7.2,2.8,10.9,"thymus: 10.9 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000173611,SCAI,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.782061,-0.53,-0.755957
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,40.1,14.4,14.8,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); colon: 14.4 nTPM (protected, limit 12); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 6); heart muscle: 11.9 nTPM (vital, limit 6); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 6); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 6); stomach: 8.1 nTPM (protected, limit 2); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000173621,LRFN4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 60.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.0682% (minimum 99%, Baseline (adaptation disabled)); amygdala: 53.6232% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.9890% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.3846% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 35.6340% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.0519% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.1039% (minimum 99%, Baseline (adaptation disabled)); colon: 60.6557% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.0678% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.1026% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 53.7530% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.4958% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.4867% (minimum 99%, Baseline (adaptation disabled)); liver: 89.8785% (minimum 99%, Baseline (adaptation disabled)); lung: 73.2673% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.6709% (minimum 97%, Baseline (adaptation disabled)); midbrain: 72.5490% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.4462% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.8718% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 74.2475% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.4681% (minimum 97%, Baseline (adaptation disabled)); retina: 97.7974% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.3826% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 70.4762% (minimum 99%, Baseline (adaptation disabled)); skin: 70.9265% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.5699% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.6897% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.2475% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.7475% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.2673% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.8718% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 79.8561% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.1162% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.3826% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,40.1,14.4,14.8,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); adipose tissue: 14.8 nTPM (manageable, limit 5); colon: 14.4 nTPM (protected, limit 2); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); heart muscle: 11.9 nTPM (vital, limit 1); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); salivary gland: 8.9 nTPM (protected, limit 2); urinary bladder: 8.9 nTPM (protected, limit 2); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 1); stomach: 8.1 nTPM (protected, limit 2); esophagus: 7.8 nTPM (protected, limit 2); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); bone marrow: 3.8 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000173621,LRFN4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.35,-0.363443,-0.63366
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.0682% (minimum 95%, Enhanced); amygdala: 53.6232% (minimum 99%, Missing); basal ganglia: 60.9890% (minimum 99%, Missing); bone marrow: 85.3846% (minimum 95%, Enhanced); cerebellum: 35.6340% (minimum 99%, Missing); cerebral cortex: 48.0519% (minimum 99%, Missing); choroid plexus: 96.1039% (minimum 99%, Missing); colon: 60.6557% (minimum 80%, Enhanced); duodenum: 94.0678% (minimum 95%, Enhanced); esophagus: 74.0000% (minimum 80%, Enhanced); heart muscle: 65.1026% (minimum 95%, Enhanced); hippocampal formation: 53.7530% (minimum 99%, Missing); hypothalamus: 61.4958% (minimum 99%, Missing); kidney: 65.4867% (minimum 99%, Missing); liver: 89.8785% (minimum 95%, Enhanced); lung: 73.2673% (minimum 95%, Enhanced); midbrain: 72.5490% (minimum 99%, Missing); pancreas: 88.4462% (minimum 95%, Enhanced); pituitary gland: 74.2475% (minimum 99%, Missing); retina: 97.7974% (minimum 99%, Missing); salivary gland: 71.3826% (minimum 80%, Enhanced); skeletal muscle: 70.4762% (minimum 95%, Enhanced); small intestine: 79.5699% (minimum 95%, Enhanced); spinal cord: 74.2475% (minimum 99%, Missing); stomach: 73.2673% (minimum 97%, Missing); thymus: 94.8718% (minimum 95%, Missing); tongue: 92.1162% (minimum 97%, Missing); urinary bladder: 71.3826% (minimum 80%, Enhanced)",0,4,partial,40.1,14.4,14.8,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); colon: 14.4 nTPM (protected, limit 12); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 6); heart muscle: 11.9 nTPM (vital, limit 6); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 6); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 6); stomach: 8.1 nTPM (protected, limit 2); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000173621,LRFN4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.00128205,-0.237327,-0.63366
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.1,0,"lung: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000173627,APOBEC4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 92.5620% (minimum 99%, Baseline (adaptation disabled)); lung: 91.0569% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.1,0,"lung: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000173627,APOBEC4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.0211504,-0.0794309
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 92.5620% (minimum 99%, Missing); lung: 91.0569% (minimum 99%, Missing)",0,80,unavailable,1.1,0.1,0,"lung: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000173627,APOBEC4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.0211504,-0.0794309
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000173673,HES3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"thymus: 12.5000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,0.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000173673,HES3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.825,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"thymus: 12.5000% (minimum 95%, Missing)",0,80,unavailable,0,0,0.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000173673,HES3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.825,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0.3,0.2,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000173699,SPATA3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.3,0.2,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000173699,SPATA3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0494183,0.0288372,0.00825683
True,compatible,,True,True,True,,0,1,partial,0.3,0.2,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000173699,SPATA3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00825683
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1135.6,1,0.9,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000173714,WFIKKN2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"cerebellum: 98.6760% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 11.0868% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.4701% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.5386% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1135.6,1,0.9,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000173714,WFIKKN2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0436842,0.0229874,-0.879132
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"cerebellum: 98.6760% (minimum 99%, Missing); choroid plexus: 11.0868% (minimum 99%, Missing); pituitary gland: 98.4701% (minimum 99%, Missing); skeletal muscle: 98.5386% (minimum 99%, Missing)",0,80,unavailable,1135.6,1,0.9,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000173714,WFIKKN2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0436842,0.0229874,-0.879132
True,compatible,,True,True,False,,0,80,unavailable,0,0.5,0,,,0,not_established,not_triggered,,,ENSG00000173728,SPMIP3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0.5,0,,,0,not_established,not_triggered,,,ENSG00000173728,SPMIP3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.0155072,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0.5,0,,,0,not_established,not_triggered,,,ENSG00000173728,SPMIP3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.0155072,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000173769,TOPAZ1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000173769,TOPAZ1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000173769,TOPAZ1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.6,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173809,TDRD12,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 95.8621% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5816% (minimum 99%, Baseline (adaptation disabled)); retina: 98.5816% (minimum 99%, Baseline (adaptation disabled)); skin: 94.5578% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.2028% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173809,TDRD12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025;da Silva 2017,-0.00442177,0.0158156,-0.0313793
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 95.8621% (minimum 99%, Missing); hypothalamus: 98.5816% (minimum 99%, Missing); retina: 98.5816% (minimum 99%, Missing); skin: 94.5578% (minimum 95%, Missing); small intestine: 97.2028% (minimum 99%, Missing)",0,80,unavailable,0.6,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173809,TDRD12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025;da Silva 2017,-0.00442177,0.0158156,-0.0313793
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,25.5,10.6,14.5,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); skin: 14.5 nTPM (manageable, limit 5); spleen: 13.1 nTPM (manageable, limit 5); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 2); hypothalamus: 10.5 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); stomach: 9.2 nTPM (protected, limit 2); pituitary gland: 9 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); small intestine: 8.9 nTPM (vital, limit 1); thyroid gland: 8.9 nTPM (manageable, limit 5); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 2); tongue: 5.3 nTPM (protected, limit 2); lymph node: 5.1 nTPM (protected, limit 2); thymus: 5.1 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173818,ENDOV,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 71.2963% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.0385% (minimum 99%, Baseline (adaptation disabled)); amygdala: 69.3694% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.1667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 66.9565% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.6250% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.4138% (minimum 99%, Baseline (adaptation disabled)); colon: 68.5460% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.1096% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.9626% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 78.0405% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 69.3694% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.7500% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.3133% (minimum 99%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 99%, Baseline (adaptation disabled)); lung: 71.0769% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.9149% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.8019% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.3694% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.4878% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.9626% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.6957% (minimum 97%, Baseline (adaptation disabled)); retina: 47.5309% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.5783% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.4391% (minimum 99%, Baseline (adaptation disabled)); skin: 61.4362% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.1875% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.7957% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.2963% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.8122% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.5170% (minimum 97%, Baseline (adaptation disabled)); thymus: 81.9149% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 72.1875% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.3380% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.9626% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,25.5,10.6,14.5,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); skin: 14.5 nTPM (manageable, limit 5); spleen: 13.1 nTPM (manageable, limit 5); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 2); hypothalamus: 10.5 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); stomach: 9.2 nTPM (protected, limit 2); pituitary gland: 9 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); small intestine: 8.9 nTPM (vital, limit 1); thyroid gland: 8.9 nTPM (manageable, limit 5); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 2); tongue: 5.3 nTPM (protected, limit 2); lymph node: 5.1 nTPM (protected, limit 2); thymus: 5.1 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173818,ENDOV,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.335638,-0.28454,-0.514691
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 71.2963% (minimum 95%, Missing); adrenal gland: 74.0385% (minimum 99%, Missing); amygdala: 69.3694% (minimum 99%, Missing); basal ganglia: 64.1667% (minimum 99%, Missing); bone marrow: 82.5000% (minimum 99%, Missing); cerebellum: 66.9565% (minimum 99%, Missing); cerebral cortex: 65.6250% (minimum 99%, Missing); choroid plexus: 72.4138% (minimum 99%, Missing); colon: 68.5460% (minimum 97%, Missing); duodenum: 79.1096% (minimum 99%, Missing); esophagus: 71.9626% (minimum 97%, Missing); heart muscle: 78.0405% (minimum 99%, Missing); hippocampal formation: 69.3694% (minimum 99%, Missing); hypothalamus: 68.7500% (minimum 99%, Missing); kidney: 60.3133% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Missing); lung: 71.0769% (minimum 99%, Missing); lymph node: 81.9149% (minimum 97%, Missing); midbrain: 73.8019% (minimum 99%, Missing); pancreas: 69.3694% (minimum 99%, Missing); parathyroid gland: 80.4878% (minimum 97%, Missing); pituitary gland: 71.9626% (minimum 99%, Missing); rectum: 83.6957% (minimum 97%, Missing); retina: 47.5309% (minimum 99%, Missing); salivary gland: 69.5783% (minimum 97%, Missing); skeletal muscle: 65.4391% (minimum 99%, Missing); skin: 61.4362% (minimum 95%, Missing); small intestine: 72.1875% (minimum 99%, Missing); smooth muscle: 82.7957% (minimum 99%, Missing); spinal cord: 71.2963% (minimum 99%, Missing); spleen: 63.8122% (minimum 95%, Missing); stomach: 71.5170% (minimum 97%, Missing); thymus: 81.9149% (minimum 95%, Missing); thyroid gland: 72.1875% (minimum 95%, Missing); tongue: 81.3380% (minimum 97%, Missing); urinary bladder: 71.9626% (minimum 97%, Missing)",0,80,unavailable,25.5,10.6,14.5,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); skin: 14.5 nTPM (manageable, limit 5); spleen: 13.1 nTPM (manageable, limit 5); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 2); hypothalamus: 10.5 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); stomach: 9.2 nTPM (protected, limit 2); pituitary gland: 9 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); small intestine: 8.9 nTPM (vital, limit 1); thyroid gland: 8.9 nTPM (manageable, limit 5); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 2); tongue: 5.3 nTPM (protected, limit 2); lymph node: 5.1 nTPM (protected, limit 2); thymus: 5.1 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173818,ENDOV,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.335638,-0.28454,-0.514691
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,17.8,1,0.2,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000173838,MARCHF10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.5262% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.0247% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.2508% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.9487% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.8770% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8905% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0924% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.5753% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,17.8,1,0.2,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000173838,MARCHF10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0485063,0.0225761,-0.107492
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.5262% (minimum 99%, Missing); basal ganglia: 97.0247% (minimum 99%, Missing); choroid plexus: 88.2508% (minimum 99%, Missing); hippocampal formation: 97.9487% (minimum 99%, Missing); hypothalamus: 97.8770% (minimum 99%, Missing); pituitary gland: 91.5753% (minimum 99%, Missing)",0,1,partial,17.8,1,0.2,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,ENSG00000173838,MARCHF10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0485063,0.03,-0.107492
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,18.7,3.1,13.8,"bone marrow: 18.7 nTPM (vital, limit 1); spleen: 13.8 nTPM (manageable, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173868,PHOSPHO1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.7179% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.9130% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.8154% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.2593% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.3426% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.2789% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.3301% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.1373% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7179% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.7179% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7539% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.5634% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.8154% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.8085% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.1845% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7179% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.8841% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.9961% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,18.7,3.1,13.8,"bone marrow: 18.7 nTPM (vital, limit 1); spleen: 13.8 nTPM (manageable, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173868,PHOSPHO1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0711589,-3.87597e-05,-0.147407
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.7179% (minimum 99%, Missing); amygdala: 98.9130% (minimum 99%, Missing); basal ganglia: 98.8154% (minimum 99%, Missing); bone marrow: 84.2593% (minimum 99%, Missing); cerebral cortex: 96.3426% (minimum 99%, Missing); duodenum: 97.2789% (minimum 99%, Missing); heart muscle: 98.3301% (minimum 99%, Missing); hippocampal formation: 98.1373% (minimum 99%, Missing); hypothalamus: 98.7179% (minimum 99%, Missing); kidney: 98.7179% (minimum 99%, Missing); lung: 97.7539% (minimum 99%, Missing); midbrain: 97.5634% (minimum 99%, Missing); pancreas: 98.8154% (minimum 99%, Missing); skeletal muscle: 96.8085% (minimum 99%, Missing); small intestine: 97.1845% (minimum 99%, Missing); spinal cord: 98.7179% (minimum 99%, Missing); spleen: 87.8841% (minimum 95%, Missing); tongue: 96.9961% (minimum 97%, Missing)",0,80,unavailable,18.7,3.1,13.8,"bone marrow: 18.7 nTPM (vital, limit 1); spleen: 13.8 nTPM (manageable, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173868,PHOSPHO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0711589,-3.87597e-05,-0.147407
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,50.3,17.6,16.3,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 2); thymus: 16.3 nTPM (manageable, limit 5); thyroid gland: 16.1 nTPM (manageable, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 2); spleen: 13.6 nTPM (manageable, limit 5); tongue: 13.4 nTPM (protected, limit 2); smooth muscle: 12.9 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); urinary bladder: 11.4 nTPM (protected, limit 2); pancreas: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 2); duodenum: 10.9 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 2); kidney: 9.4 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); salivary gland: 8.6 nTPM (protected, limit 2); liver: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173889,PHC3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4879% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.3037% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.9524% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 19.1318% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.2316% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.8333% (minimum 99%, Baseline (adaptation disabled)); colon: 54.0909% (minimum 97%, Baseline (adaptation disabled)); duodenum: 52.1930% (minimum 99%, Baseline (adaptation disabled)); esophagus: 49.7908% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.4061% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.8658% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.4054% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.8685% (minimum 99%, Baseline (adaptation disabled)); liver: 58.6207% (minimum 99%, Baseline (adaptation disabled)); lung: 55.8685% (minimum 99%, Baseline (adaptation disabled)); lymph node: 40.3390% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.4054% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.1930% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 44.9057% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.1860% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.1930% (minimum 97%, Baseline (adaptation disabled)); retina: 22.6236% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.0488% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.6207% (minimum 99%, Baseline (adaptation disabled)); skin: 58.9109% (minimum 95%, Baseline (adaptation disabled)); small intestine: 49.7908% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 47.9839% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.8428% (minimum 99%, Baseline (adaptation disabled)); spleen: 46.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.8547% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.1986% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 42.5000% (minimum 95%, Baseline (adaptation disabled)); tongue: 47.0356% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.0730% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,50.3,17.6,16.3,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 2); thymus: 16.3 nTPM (manageable, limit 5); thyroid gland: 16.1 nTPM (manageable, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 2); spleen: 13.6 nTPM (manageable, limit 5); tongue: 13.4 nTPM (protected, limit 2); smooth muscle: 12.9 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); urinary bladder: 11.4 nTPM (protected, limit 2); pancreas: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 2); duodenum: 10.9 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 2); kidney: 9.4 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); salivary gland: 8.6 nTPM (protected, limit 2); liver: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173889,PHC3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.528014,-0.56661,-0.798682
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4879% (minimum 95%, Missing); adrenal gland: 62.3037% (minimum 99%, Missing); amygdala: 80.9524% (minimum 99%, Missing); basal ganglia: 79.3333% (minimum 99%, Missing); bone marrow: 19.1318% (minimum 99%, Missing); cerebellum: 70.0000% (minimum 99%, Missing); cerebral cortex: 67.2316% (minimum 99%, Missing); choroid plexus: 70.8333% (minimum 99%, Missing); colon: 54.0909% (minimum 97%, Missing); duodenum: 52.1930% (minimum 99%, Missing); esophagus: 49.7908% (minimum 97%, Missing); heart muscle: 60.4061% (minimum 99%, Missing); hippocampal formation: 79.8658% (minimum 99%, Missing); hypothalamus: 80.4054% (minimum 99%, Missing); kidney: 55.8685% (minimum 99%, Missing); liver: 58.6207% (minimum 99%, Missing); lung: 55.8685% (minimum 99%, Missing); lymph node: 40.3390% (minimum 97%, Missing); midbrain: 80.4054% (minimum 99%, Missing); pancreas: 52.1930% (minimum 99%, Missing); parathyroid gland: 44.9057% (minimum 97%, Missing); pituitary gland: 69.1860% (minimum 99%, Missing); rectum: 52.1930% (minimum 97%, Missing); retina: 22.6236% (minimum 99%, Missing); salivary gland: 58.0488% (minimum 97%, Missing); skeletal muscle: 58.6207% (minimum 99%, Missing); skin: 58.9109% (minimum 95%, Missing); small intestine: 49.7908% (minimum 99%, Missing); smooth muscle: 47.9839% (minimum 99%, Missing); spinal cord: 74.8428% (minimum 99%, Missing); spleen: 46.6667% (minimum 95%, Missing); stomach: 50.8547% (minimum 97%, Missing); thymus: 42.1986% (minimum 95%, Missing); thyroid gland: 42.5000% (minimum 95%, Missing); tongue: 47.0356% (minimum 97%, Missing); urinary bladder: 51.0730% (minimum 97%, Missing)",0,4,partial,50.3,17.6,16.3,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 2); thymus: 16.3 nTPM (manageable, limit 5); thyroid gland: 16.1 nTPM (manageable, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 2); spleen: 13.6 nTPM (manageable, limit 5); tongue: 13.4 nTPM (protected, limit 2); smooth muscle: 12.9 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 2); stomach: 11.5 nTPM (protected, limit 2); urinary bladder: 11.4 nTPM (protected, limit 2); pancreas: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 2); duodenum: 10.9 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 2); kidney: 9.4 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); salivary gland: 8.6 nTPM (protected, limit 2); liver: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173889,PHC3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.528014,-0.56661,-0.798682
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,2.2,4.1,7.2,"thymus: 7.2 nTPM (manageable, limit 5); esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 2); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173894,CBX2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.9281% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.6562% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.6562% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.1538% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.0340% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.4252% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.6970% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.4252% (minimum 99%, Baseline (adaptation disabled)); colon: 96.1538% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.6562% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.3012% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.0340% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.8992% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.6562% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.6525% (minimum 99%, Baseline (adaptation disabled)); liver: 96.8992% (minimum 99%, Baseline (adaptation disabled)); lung: 91.2409% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.5797% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.8992% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.5797% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.1538% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.4252% (minimum 99%, Baseline (adaptation disabled)); retina: 96.8992% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.9850% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.6970% (minimum 99%, Baseline (adaptation disabled)); skin: 86.2069% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.4198% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.4198% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.8992% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.6525% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.1538% (minimum 97%, Baseline (adaptation disabled)); thymus: 63.4518% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.9118% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 93.2836% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,2.2,4.1,7.2,"thymus: 7.2 nTPM (manageable, limit 5); esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173894,CBX2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.315482,-0.216988,-0.13966
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.9281% (minimum 90%, Approved); adrenal gland: 97.6562% (minimum 98%, Approved); amygdala: 97.6562% (minimum 99%, Missing); basal ganglia: 96.1538% (minimum 99%, Missing); bone marrow: 85.0340% (minimum 99%, Missing); cerebral cortex: 94.6970% (minimum 98%, Approved); choroid plexus: 98.4252% (minimum 99%, Missing); colon: 96.1538% (minimum 97%, Missing); duodenum: 97.6562% (minimum 99%, Missing); esophagus: 75.3012% (minimum 97%, Missing); heart muscle: 85.0340% (minimum 98%, Approved); hippocampal formation: 96.8992% (minimum 99%, Missing); hypothalamus: 97.6562% (minimum 99%, Missing); kidney: 88.6525% (minimum 98%, Approved); liver: 96.8992% (minimum 98%, Approved); lung: 91.2409% (minimum 99%, Missing); lymph node: 90.5797% (minimum 97%, Missing); midbrain: 96.8992% (minimum 99%, Missing); pancreas: 90.5797% (minimum 98%, Approved); parathyroid gland: 96.1538% (minimum 97%, Missing); pituitary gland: 98.4252% (minimum 99%, Missing); retina: 96.8992% (minimum 99%, Missing); salivary gland: 93.9850% (minimum 95%, Approved); skeletal muscle: 94.6970% (minimum 98%, Approved); skin: 86.2069% (minimum 95%, Missing); small intestine: 95.4198% (minimum 99%, Missing); smooth muscle: 95.4198% (minimum 98%, Approved); spinal cord: 96.8992% (minimum 99%, Missing); spleen: 88.6525% (minimum 95%, Missing); stomach: 96.1538% (minimum 97%, Missing); thymus: 63.4518% (minimum 95%, Missing); tongue: 91.9118% (minimum 97%, Missing); urinary bladder: 93.2836% (minimum 97%, Missing)",0,1,partial,2.2,4.1,7.2,"thymus: 7.2 nTPM (manageable, limit 5); esophagus: 4.1 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 2); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173894,CBX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.315482,-0.216988,-0.13966
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,5,partial,0,0,11.3,"skin: 11.3 nTPM (manageable, limit 5)",,68,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000173908,KRT28,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 70.0000% (minimum 95%, Baseline (adaptation disabled)); skin: 5.8333% (minimum 95%, Baseline (adaptation disabled))",0,5,partial,0,0,11.3,"skin: 11.3 nTPM (manageable, limit 5)",,68,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000173908,KRT28,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.891667,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"skin: 5.8333% (minimum 95%, Missing)",0,5,partial,0,0,11.3,"skin: 11.3 nTPM (manageable, limit 5)",,68,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000173908,KRT28,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.891667,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,40.1,1.9,1.6,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173930,SLCO4C1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.7436% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.3953% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.2222% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 29.1667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.1053% (minimum 99%, Baseline (adaptation disabled)); colon: 77.7778% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.5000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 92.1053% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.2222% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2222% (minimum 99%, Baseline (adaptation disabled)); kidney: 8.0275% (minimum 99%, Baseline (adaptation disabled)); liver: 32.4074% (minimum 99%, Baseline (adaptation disabled)); lung: 31.5315% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.5000% (minimum 97%, Baseline (adaptation disabled)); pancreas: 89.7436% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.5946% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.3953% (minimum 97%, Baseline (adaptation disabled)); retina: 97.2222% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.8148% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.2222% (minimum 99%, Baseline (adaptation disabled)); skin: 92.1053% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.2222% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.9167% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.3659% (minimum 97%, Baseline (adaptation disabled)); thymus: 79.5455% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.6275% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.5946% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,40.1,1.9,1.6,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173930,SLCO4C1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.263725,-0.321852,-0.909725
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.7436% (minimum 95%, Missing); adrenal gland: 81.3953% (minimum 99%, Missing); amygdala: 97.2222% (minimum 99%, Missing); bone marrow: 29.1667% (minimum 99%, Missing); cerebral cortex: 92.1053% (minimum 99%, Missing); colon: 77.7778% (minimum 97%, Missing); duodenum: 62.5000% (minimum 99%, Missing); heart muscle: 92.1053% (minimum 99%, Missing); hippocampal formation: 97.2222% (minimum 99%, Missing); hypothalamus: 97.2222% (minimum 99%, Missing); kidney: 8.0275% (minimum 99%, Missing); liver: 32.4074% (minimum 99%, Missing); lung: 31.5315% (minimum 99%, Missing); lymph node: 87.5000% (minimum 97%, Missing); pancreas: 89.7436% (minimum 99%, Missing); pituitary gland: 94.5946% (minimum 99%, Missing); rectum: 81.3953% (minimum 97%, Missing); retina: 97.2222% (minimum 99%, Missing); salivary gland: 64.8148% (minimum 97%, Missing); skeletal muscle: 97.2222% (minimum 99%, Missing); skin: 92.1053% (minimum 95%, Missing); small intestine: 70.0000% (minimum 99%, Missing); smooth muscle: 97.2222% (minimum 99%, Missing); spleen: 72.9167% (minimum 95%, Missing); stomach: 85.3659% (minimum 97%, Missing); thymus: 79.5455% (minimum 95%, Missing); thyroid gland: 68.6275% (minimum 95%, Missing); urinary bladder: 94.5946% (minimum 97%, Missing)",0,80,unavailable,40.1,1.9,1.6,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000173930,SLCO4C1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.263725,-0.321852,-0.909725
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,129.5,97.5,106.8,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); thymus: 106.8 nTPM (manageable, limit 5); spleen: 102.3 nTPM (manageable, limit 5); esophagus: 97.5 nTPM (protected, limit 2); stomach: 95.5 nTPM (protected, limit 2); lymph node: 95.2 nTPM (protected, limit 2); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 2); salivary gland: 86.5 nTPM (protected, limit 2); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (manageable, limit 5); urinary bladder: 81.5 nTPM (protected, limit 2); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (manageable, limit 5); skin: 78.4 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 2); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 2); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 2); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); spinal cord: 56 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173933,RBM4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6604% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 48.1517% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.5702% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.2595% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 43.6466% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 47.6711% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.7660% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.0776% (minimum 99%, Baseline (adaptation disabled)); colon: 51.9151% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.4217% (minimum 99%, Baseline (adaptation disabled)); esophagus: 50.7078% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.8098% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.4008% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.8754% (minimum 99%, Baseline (adaptation disabled)); kidney: 46.3066% (minimum 99%, Baseline (adaptation disabled)); liver: 55.5371% (minimum 99%, Baseline (adaptation disabled)); lung: 57.2162% (minimum 99%, Baseline (adaptation disabled)); lymph node: 51.3043% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.1715% (minimum 99%, Baseline (adaptation disabled)); pancreas: 47.2000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.3471% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 54.4813% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.3756% (minimum 97%, Baseline (adaptation disabled)); retina: 58.3140% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.6938% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 51.8346% (minimum 99%, Baseline (adaptation disabled)); skin: 56.1276% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.2313% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.2041% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.1715% (minimum 99%, Baseline (adaptation disabled)); spleen: 49.5064% (minimum 95%, Baseline (adaptation disabled)); stomach: 51.2257% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.4307% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.6892% (minimum 95%, Baseline (adaptation disabled)); tongue: 59.0695% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.1705% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,129.5,97.5,106.8,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); thymus: 106.8 nTPM (manageable, limit 5); spleen: 102.3 nTPM (manageable, limit 5); esophagus: 97.5 nTPM (protected, limit 2); stomach: 95.5 nTPM (protected, limit 2); lymph node: 95.2 nTPM (protected, limit 2); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 2); salivary gland: 86.5 nTPM (protected, limit 2); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (manageable, limit 5); urinary bladder: 81.5 nTPM (protected, limit 2); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (manageable, limit 5); skin: 78.4 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 2); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 2); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 2); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); spinal cord: 56 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173933,RBM4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.465693,-0.462922,-0.553534
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6604% (minimum 95%, Missing); adrenal gland: 48.1517% (minimum 99%, Missing); amygdala: 62.5702% (minimum 99%, Missing); basal ganglia: 62.2595% (minimum 99%, Missing); bone marrow: 43.6466% (minimum 99%, Missing); cerebellum: 47.6711% (minimum 99%, Missing); cerebral cortex: 62.7660% (minimum 99%, Missing); choroid plexus: 58.0776% (minimum 99%, Missing); colon: 51.9151% (minimum 97%, Missing); duodenum: 60.4217% (minimum 99%, Missing); esophagus: 50.7078% (minimum 97%, Missing); heart muscle: 57.8098% (minimum 99%, Missing); hippocampal formation: 63.4008% (minimum 99%, Missing); hypothalamus: 61.8754% (minimum 99%, Missing); kidney: 46.3066% (minimum 99%, Missing); liver: 55.5371% (minimum 99%, Missing); lung: 57.2162% (minimum 99%, Missing); lymph node: 51.3043% (minimum 97%, Missing); midbrain: 64.1715% (minimum 99%, Missing); pancreas: 47.2000% (minimum 99%, Missing); parathyroid gland: 57.3471% (minimum 97%, Missing); pituitary gland: 54.4813% (minimum 99%, Missing); rectum: 62.3756% (minimum 97%, Missing); retina: 58.3140% (minimum 99%, Missing); salivary gland: 53.6938% (minimum 97%, Missing); skeletal muscle: 51.8346% (minimum 99%, Missing); skin: 56.1276% (minimum 95%, Missing); small intestine: 55.2313% (minimum 99%, Missing); smooth muscle: 60.2041% (minimum 99%, Missing); spinal cord: 64.1715% (minimum 99%, Missing); spleen: 49.5064% (minimum 95%, Missing); stomach: 51.2257% (minimum 97%, Missing); thymus: 48.4307% (minimum 95%, Missing); thyroid gland: 54.6892% (minimum 95%, Missing); tongue: 59.0695% (minimum 97%, Missing); urinary bladder: 55.1705% (minimum 97%, Missing)",0,0,routine_complete,129.5,97.5,106.8,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); thymus: 106.8 nTPM (manageable, limit 5); spleen: 102.3 nTPM (manageable, limit 5); esophagus: 97.5 nTPM (protected, limit 2); stomach: 95.5 nTPM (protected, limit 2); lymph node: 95.2 nTPM (protected, limit 2); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 2); salivary gland: 86.5 nTPM (protected, limit 2); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (manageable, limit 5); urinary bladder: 81.5 nTPM (protected, limit 2); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (manageable, limit 5); skin: 78.4 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 2); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 2); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 2); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); spinal cord: 56 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000173933,RBM4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.465693,-0.462922,-0.553534
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4,0.3,1.2,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000173988,LRRC63,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.1892% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.2857% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.0588% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.4878% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.8421% (minimum 99%, Baseline (adaptation disabled)); liver: 97.0588% (minimum 99%, Baseline (adaptation disabled)); lung: 89.1892% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.2857% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.7500% (minimum 99%, Baseline (adaptation disabled)); retina: 58.9286% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.6667% (minimum 97%, Baseline (adaptation disabled)); smooth muscle: 97.0588% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 45.2055% (minimum 99%, Baseline (adaptation disabled)); thymus: 73.3333% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,4,0.3,1.2,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000173988,LRRC63,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.216667,-0.0533333,-0.537945
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.6667% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 91.6667% (minimum 99%, Missing); bone marrow: 89.1892% (minimum 99%, Missing); cerebral cortex: 73.3333% (minimum 99%, Missing); choroid plexus: 94.2857% (minimum 99%, Missing); heart muscle: 97.0588% (minimum 99%, Missing); hippocampal formation: 80.4878% (minimum 99%, Missing); hypothalamus: 86.8421% (minimum 99%, Missing); liver: 97.0588% (minimum 99%, Missing); lung: 89.1892% (minimum 99%, Missing); lymph node: 94.2857% (minimum 97%, Missing); midbrain: 68.7500% (minimum 99%, Missing); retina: 58.9286% (minimum 99%, Missing); salivary gland: 91.6667% (minimum 97%, Missing); smooth muscle: 97.0588% (minimum 99%, Missing); spinal cord: 45.2055% (minimum 99%, Missing); thymus: 73.3333% (minimum 95%, Missing)",0,80,unavailable,4,0.3,1.2,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000173988,LRRC63,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.216667,-0.0533333,-0.537945
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,6.4,3.2,7.4,"thymus: 7.4 nTPM (manageable, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174007,CEP19,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.3388% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.1329% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.7595% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.7196% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.7273% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 87.2727% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.4286% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.2727% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.0734% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.1329% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.4295% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.3388% (minimum 99%, Baseline (adaptation disabled)); liver: 89.7196% (minimum 99%, Baseline (adaptation disabled)); lung: 85.7143% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.4194% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.6418% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.2039% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.1805% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.4286% (minimum 97%, Baseline (adaptation disabled)); retina: 60.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.7196% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); skin: 85.7143% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.7196% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.0734% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.3388% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.4186% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.4286% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.4706% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.3559% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.2105% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.9558% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,6.4,3.2,7.4,"thymus: 7.4 nTPM (manageable, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174007,CEP19,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.385294,-0.22,-0.39
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 79.3388% (minimum 95%, Enhanced); amygdala: 67.1329% (minimum 99%, Missing); basal ganglia: 60.7595% (minimum 99%, Missing); bone marrow: 89.7196% (minimum 95%, Enhanced); cerebellum: 72.7273% (minimum 99%, Missing); cerebral cortex: 60.0000% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 87.2727% (minimum 97%, Missing); duodenum: 91.4286% (minimum 99%, Missing); heart muscle: 88.0734% (minimum 95%, Enhanced); hippocampal formation: 67.1329% (minimum 99%, Missing); hypothalamus: 64.4295% (minimum 99%, Missing); kidney: 79.3388% (minimum 95%, Enhanced); liver: 89.7196% (minimum 95%, Enhanced); lung: 85.7143% (minimum 99%, Missing); lymph node: 77.4194% (minimum 80%, Enhanced); midbrain: 71.6418% (minimum 99%, Missing); pancreas: 93.2039% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 80%, Enhanced); pituitary gland: 72.1805% (minimum 99%, Missing); rectum: 91.4286% (minimum 97%, Missing); retina: 60.0000% (minimum 99%, Missing); skeletal muscle: 94.1176% (minimum 95%, Enhanced); small intestine: 89.7196% (minimum 99%, Missing); smooth muscle: 88.0734% (minimum 95%, Enhanced); spinal cord: 79.3388% (minimum 99%, Missing); thymus: 56.4706% (minimum 95%, Missing); tongue: 84.2105% (minimum 97%, Missing)",0,5,partial,6.4,3.2,7.4,"thymus: 7.4 nTPM (manageable, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174007,CEP19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.385294,-0.127895,-0.39
True,compatible,,True,True,False,,0,1,partial,0.1,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000174015,CBY2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000174015,CBY2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0479275,0.0289627,0.00896266
True,compatible,,True,True,True,,0,1,partial,0.1,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000174015,CBY2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000174016,TENT5D,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000174016,TENT5D,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000174016,TENT5D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.6,0.8,1.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174038,C9orf131,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.0481% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.0282% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.8636% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0282% (minimum 99%, Baseline (adaptation disabled)); retina: 96.1326% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.6667% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.6,0.8,1.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174038,C9orf131,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.0193593,0.00752809,-0.0595187
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.0481% (minimum 99%, Missing); cerebral cortex: 98.0282% (minimum 99%, Missing); heart muscle: 98.8636% (minimum 99%, Missing); liver: 98.0282% (minimum 99%, Missing); retina: 96.1326% (minimum 99%, Missing); skeletal muscle: 96.6667% (minimum 99%, Missing)",0,80,unavailable,2.6,0.8,1.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174038,C9orf131,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.0193593,0.00752809,-0.0595187
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,8.3,5.5,5.4,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); thyroid gland: 5.4 nTPM (manageable, limit 5); skin: 5.4 nTPM (manageable, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000174206,KICS2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.4321% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 56.9892% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.4321% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.6392% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.6479% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.8889% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.6479% (minimum 99%, Baseline (adaptation disabled)); colon: 66.2500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 63.8554% (minimum 99%, Baseline (adaptation disabled)); esophagus: 56.3830% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 62.3529% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.6341% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 38.9706% (minimum 99%, Baseline (adaptation disabled)); lung: 66.2500% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.4752% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.6279% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.4563% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.0741% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.9487% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.8554% (minimum 97%, Baseline (adaptation disabled)); retina: 77.9412% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.4321% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.2083% (minimum 99%, Baseline (adaptation disabled)); skin: 49.5327% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.8312% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.5506% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.4752% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.8554% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.3529% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 49.5327% (minimum 95%, Baseline (adaptation disabled)); tongue: 63.0952% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.9487% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,8.3,5.5,5.4,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); thyroid gland: 5.4 nTPM (manageable, limit 5); skin: 5.4 nTPM (manageable, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000174206,KICS2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.454673,-0.479259,-0.600294
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.4321% (minimum 95%, Uncertain); adrenal gland: 56.9892% (minimum 99%, Uncertain); amygdala: 65.4321% (minimum 99%, Missing); basal ganglia: 54.6392% (minimum 99%, Missing); bone marrow: 75.7143% (minimum 99%, Missing); cerebellum: 74.6479% (minimum 99%, Uncertain); cerebral cortex: 58.8889% (minimum 99%, Missing); choroid plexus: 74.6479% (minimum 99%, Missing); colon: 66.2500% (minimum 97%, Missing); duodenum: 63.8554% (minimum 99%, Missing); esophagus: 56.3830% (minimum 97%, Uncertain); heart muscle: 70.6667% (minimum 99%, Uncertain); hippocampal formation: 62.3529% (minimum 99%, Missing); hypothalamus: 64.6341% (minimum 99%, Missing); kidney: 50.0000% (minimum 99%, Missing); liver: 38.9706% (minimum 99%, Uncertain); lung: 66.2500% (minimum 99%, Missing); lymph node: 52.4752% (minimum 97%, Uncertain); midbrain: 61.6279% (minimum 99%, Missing); pancreas: 51.4563% (minimum 99%, Missing); parathyroid gland: 49.0741% (minimum 97%, Uncertain); pituitary gland: 67.9487% (minimum 99%, Missing); rectum: 63.8554% (minimum 97%, Missing); retina: 77.9412% (minimum 99%, Missing); salivary gland: 65.4321% (minimum 97%, Uncertain); skeletal muscle: 55.2083% (minimum 99%, Uncertain); skin: 49.5327% (minimum 95%, Uncertain); small intestine: 68.8312% (minimum 99%, Missing); smooth muscle: 70.6667% (minimum 99%, Uncertain); spinal cord: 59.5506% (minimum 99%, Missing); spleen: 52.4752% (minimum 95%, Uncertain); stomach: 63.8554% (minimum 97%, Missing); thymus: 62.3529% (minimum 95%, Missing); thyroid gland: 49.5327% (minimum 95%, Missing); tongue: 63.0952% (minimum 97%, Missing); urinary bladder: 67.9487% (minimum 97%, Missing)",0,4,partial,8.3,5.5,5.4,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); thyroid gland: 5.4 nTPM (manageable, limit 5); skin: 5.4 nTPM (manageable, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 2); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); lung: 2.7 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000174206,KICS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.454673,-0.479259,-0.600294
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.3,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000174225,ARL13A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Gong 2021;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.0392% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0392% (minimum 99%, Baseline (adaptation disabled)); duodenum: 94.3396% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.3396% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.0392% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0392% (minimum 99%, Baseline (adaptation disabled)); retina: 94.3396% (minimum 99%, Baseline (adaptation disabled)); skin: 87.7193% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.1538% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 94.3396% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.3,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000174225,ARL13A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Gong 2021;Carter 2023,-0.072807,-0.0266038,-0.0466038
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.0392% (minimum 99%, Missing); bone marrow: 98.0392% (minimum 99%, Missing); duodenum: 94.3396% (minimum 99%, Missing); esophagus: 94.3396% (minimum 97%, Missing); heart muscle: 98.0392% (minimum 99%, Missing); lung: 98.0392% (minimum 99%, Missing); retina: 94.3396% (minimum 99%, Missing); skin: 87.7193% (minimum 95%, Missing); small intestine: 96.1538% (minimum 99%, Missing); thyroid gland: 94.3396% (minimum 95%, Missing)",0,80,unavailable,0.3,0.3,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000174225,ARL13A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Gong 2021;Carter 2023,-0.072807,-0.0266038,-0.0466038
True,compatible,,True,True,False,,0,80,unavailable,0,0.9,0,,,0,not_established,not_triggered,,,ENSG00000174279,EVX2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"colon: 76.3158% (minimum 97%, Baseline (adaptation disabled)); rectum: 82.8571% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0,0.9,0,,,0,not_established,not_triggered,,,ENSG00000174279,EVX2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.206842,0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"colon: 76.3158% (minimum 97%, Missing); rectum: 82.8571% (minimum 97%, Missing)",0,80,unavailable,0,0.9,0,,,0,not_established,not_triggered,,,ENSG00000174279,EVX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.206842,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,17.1,5.7,10.8,"bone marrow: 17.1 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 5.7 nTPM (protected, limit 2); rectum: 3.6 nTPM (protected, limit 2); colon: 3.1 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174371,EXO1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.8276% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.4912% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.4912% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 24.3363% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.1639% (minimum 99%, Baseline (adaptation disabled)); colon: 63.9535% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.2651% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.6203% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.4912% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.4912% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.2143% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.8276% (minimum 99%, Baseline (adaptation disabled)); liver: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.1071% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.2143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.8276% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.7097% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.2143% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.4396% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 93.2203% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.2143% (minimum 99%, Baseline (adaptation disabled)); skin: 75.3425% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.6203% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2143% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.5714% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.5714% (minimum 97%, Baseline (adaptation disabled)); thymus: 33.7423% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.8276% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 82.0896% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,17.1,5.7,10.8,"bone marrow: 17.1 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 5.7 nTPM (protected, limit 2); rectum: 3.6 nTPM (protected, limit 2); colon: 3.1 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174371,EXO1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.612577,-0.478929,-0.746637
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Missing); adrenal gland: 94.8276% (minimum 99%, Missing); amygdala: 96.4912% (minimum 99%, Missing); basal ganglia: 96.4912% (minimum 99%, Missing); bone marrow: 24.3363% (minimum 99%, Missing); cerebral cortex: 90.1639% (minimum 99%, Missing); colon: 63.9535% (minimum 97%, Missing); duodenum: 66.2651% (minimum 99%, Missing); esophagus: 69.6203% (minimum 97%, Missing); heart muscle: 96.4912% (minimum 99%, Missing); hippocampal formation: 96.4912% (minimum 99%, Missing); hypothalamus: 98.2143% (minimum 99%, Missing); kidney: 94.8276% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 91.6667% (minimum 99%, Missing); lymph node: 49.1071% (minimum 97%, Missing); midbrain: 98.2143% (minimum 99%, Missing); pancreas: 94.8276% (minimum 99%, Missing); parathyroid gland: 88.7097% (minimum 97%, Missing); pituitary gland: 98.2143% (minimum 99%, Missing); rectum: 60.4396% (minimum 97%, Missing); salivary gland: 93.2203% (minimum 97%, Missing); skeletal muscle: 98.2143% (minimum 99%, Missing); skin: 75.3425% (minimum 95%, Missing); small intestine: 69.6203% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spinal cord: 98.2143% (minimum 99%, Missing); spleen: 78.5714% (minimum 95%, Missing); stomach: 78.5714% (minimum 97%, Missing); thymus: 33.7423% (minimum 95%, Missing); thyroid gland: 94.8276% (minimum 95%, Missing); urinary bladder: 82.0896% (minimum 97%, Missing)",0,80,unavailable,17.1,5.7,10.8,"bone marrow: 17.1 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 5.7 nTPM (protected, limit 2); rectum: 3.6 nTPM (protected, limit 2); colon: 3.1 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174371,EXO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.612577,-0.478929,-0.746637
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,8,partial,25.4,11.1,21.6,"retina: 25.4 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); lymph node: 11 nTPM (protected, limit 2); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (manageable, limit 5); midbrain: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 2); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); cerebellum: 6.6 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); colon: 5.6 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); salivary gland: 4.4 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000174405,LIG4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.7381% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.4944% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.8765% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.7879% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.7842% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 59.5092% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 45.1163% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.6250% (minimum 99%, Baseline (adaptation disabled)); colon: 63.3987% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.0838% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.2857% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.8765% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.7471% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.5912% (minimum 99%, Baseline (adaptation disabled)); kidney: 54.8023% (minimum 99%, Baseline (adaptation disabled)); liver: 43.4978% (minimum 99%, Baseline (adaptation disabled)); lung: 58.0838% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.8599% (minimum 97%, Baseline (adaptation disabled)); midbrain: 56.7251% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.5405% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 46.6346% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.7381% (minimum 99%, Baseline (adaptation disabled)); rectum: 59.5092% (minimum 97%, Baseline (adaptation disabled)); retina: 27.6353% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.7943% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.0838% (minimum 99%, Baseline (adaptation disabled)); skin: 65.5405% (minimum 95%, Baseline (adaptation disabled)); small intestine: 58.7879% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.1463% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.2967% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.1899% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.7471% (minimum 97%, Baseline (adaptation disabled)); thymus: 30.9904% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.0694% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.6250% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.7879% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,25.4,11.1,21.6,"retina: 25.4 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); lymph node: 11 nTPM (protected, limit 2); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (manageable, limit 5); midbrain: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 2); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); cerebellum: 6.6 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); colon: 5.6 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); salivary gland: 4.4 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000174405,LIG4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.640096,-0.503654,-0.713647
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.7381% (minimum 95%, Missing); adrenal gland: 54.4944% (minimum 99%, Missing); amygdala: 59.8765% (minimum 99%, Missing); basal ganglia: 58.7879% (minimum 99%, Missing); bone marrow: 69.7842% (minimum 99%, Missing); cerebellum: 59.5092% (minimum 99%, Missing); cerebral cortex: 45.1163% (minimum 99%, Missing); choroid plexus: 60.6250% (minimum 99%, Missing); colon: 63.3987% (minimum 97%, Missing); duodenum: 58.0838% (minimum 99%, Missing); esophagus: 69.2857% (minimum 97%, Missing); heart muscle: 59.8765% (minimum 99%, Missing); hippocampal formation: 55.7471% (minimum 99%, Missing); hypothalamus: 53.5912% (minimum 99%, Missing); kidney: 54.8023% (minimum 99%, Missing); liver: 43.4978% (minimum 99%, Missing); lung: 58.0838% (minimum 99%, Missing); lymph node: 46.8599% (minimum 97%, Missing); midbrain: 56.7251% (minimum 99%, Missing); pancreas: 65.5405% (minimum 99%, Missing); parathyroid gland: 46.6346% (minimum 97%, Missing); pituitary gland: 57.7381% (minimum 99%, Missing); rectum: 59.5092% (minimum 97%, Missing); retina: 27.6353% (minimum 99%, Missing); salivary gland: 68.7943% (minimum 97%, Missing); skeletal muscle: 58.0838% (minimum 99%, Missing); skin: 65.5405% (minimum 95%, Missing); small intestine: 58.7879% (minimum 99%, Missing); smooth muscle: 59.1463% (minimum 99%, Missing); spinal cord: 53.2967% (minimum 99%, Missing); spleen: 54.1899% (minimum 95%, Missing); stomach: 55.7471% (minimum 97%, Missing); thymus: 30.9904% (minimum 95%, Missing); thyroid gland: 56.0694% (minimum 95%, Missing); tongue: 60.6250% (minimum 97%, Missing); urinary bladder: 58.7879% (minimum 97%, Missing)",0,8,partial,25.4,11.1,21.6,"retina: 25.4 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 2); lymph node: 11 nTPM (protected, limit 2); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (manageable, limit 5); midbrain: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 2); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); cerebellum: 6.6 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); colon: 5.6 nTPM (protected, limit 2); pancreas: 5.1 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); salivary gland: 4.4 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000174405,LIG4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.640096,-0.503654,-0.713647
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,58,31.8,26.1,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 2); colon: 31.7 nTPM (protected, limit 2); retina: 27.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 2); pituitary gland: 26.6 nTPM (vital, limit 1); urinary bladder: 26.5 nTPM (protected, limit 2); thyroid gland: 26.1 nTPM (manageable, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 2); stomach: 22.5 nTPM (protected, limit 2); spleen: 22.2 nTPM (manageable, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); thymus: 20.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 2); salivary gland: 17.9 nTPM (protected, limit 2); esophagus: 15.3 nTPM (protected, limit 2); duodenum: 15.2 nTPM (vital, limit 1); skin: 14.7 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000174446,SNAPC5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9919% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.4089% (minimum 99%, Baseline (adaptation disabled)); amygdala: 46.7911% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 47.5682% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.1752% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.1971% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 45.9336% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 47.7381% (minimum 99%, Baseline (adaptation disabled)); colon: 55.8496% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.5136% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.3827% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 49.4451% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.0824% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 49.8137% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.6172% (minimum 99%, Baseline (adaptation disabled)); liver: 54.1161% (minimum 99%, Baseline (adaptation disabled)); lung: 68.0815% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.4494% (minimum 97%, Baseline (adaptation disabled)); midbrain: 53.7534% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.8867% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.7719% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 60.1199% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.9003% (minimum 97%, Baseline (adaptation disabled)); retina: 59.2319% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.1379% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 40.8767% (minimum 99%, Baseline (adaptation disabled)); skin: 73.1752% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.6223% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.2819% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.3150% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.3660% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.0575% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.9539% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.5740% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.1199% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.2102% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,58,31.8,26.1,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 2); colon: 31.7 nTPM (protected, limit 2); retina: 27.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 2); pituitary gland: 26.6 nTPM (vital, limit 1); urinary bladder: 26.5 nTPM (protected, limit 2); thyroid gland: 26.1 nTPM (manageable, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 2); stomach: 22.5 nTPM (protected, limit 2); spleen: 22.2 nTPM (manageable, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); thymus: 20.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 2); salivary gland: 17.9 nTPM (protected, limit 2); esophagus: 15.3 nTPM (protected, limit 2); duodenum: 15.2 nTPM (vital, limit 1); skin: 14.7 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000174446,SNAPC5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.34426,-0.412281,-0.581233
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9919% (minimum 95%, Uncertain); adrenal gland: 61.4089% (minimum 99%, Missing); amygdala: 46.7911% (minimum 99%, Missing); basal ganglia: 47.5682% (minimum 99%, Missing); bone marrow: 73.1752% (minimum 99%, Missing); cerebellum: 48.1971% (minimum 99%, Missing); cerebral cortex: 45.9336% (minimum 99%, Missing); choroid plexus: 47.7381% (minimum 99%, Missing); colon: 55.8496% (minimum 97%, Missing); duodenum: 72.5136% (minimum 99%, Missing); esophagus: 72.3827% (minimum 97%, Missing); heart muscle: 49.4451% (minimum 99%, Missing); hippocampal formation: 55.0824% (minimum 99%, Missing); hypothalamus: 49.8137% (minimum 99%, Missing); kidney: 55.6172% (minimum 99%, Missing); liver: 54.1161% (minimum 99%, Missing); lung: 68.0815% (minimum 99%, Missing); lymph node: 63.4494% (minimum 97%, Missing); midbrain: 53.7534% (minimum 99%, Missing); pancreas: 64.8867% (minimum 99%, Missing); parathyroid gland: 55.7719% (minimum 97%, Missing); pituitary gland: 60.1199% (minimum 99%, Missing); rectum: 68.9003% (minimum 97%, Missing); retina: 59.2319% (minimum 99%, Missing); salivary gland: 69.1379% (minimum 97%, Missing); skeletal muscle: 40.8767% (minimum 99%, Missing); skin: 73.1752% (minimum 95%, Missing); small intestine: 67.6223% (minimum 99%, Missing); smooth muscle: 67.2819% (minimum 99%, Uncertain); spinal cord: 61.3150% (minimum 99%, Missing); spleen: 64.3660% (minimum 95%, Missing); stomach: 64.0575% (minimum 97%, Missing); thymus: 65.9539% (minimum 95%, Missing); thyroid gland: 60.5740% (minimum 95%, Missing); tongue: 60.1199% (minimum 97%, Missing); urinary bladder: 60.2102% (minimum 97%, Missing)",0,1,partial,58,31.8,26.1,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 2); colon: 31.7 nTPM (protected, limit 2); retina: 27.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 2); pituitary gland: 26.6 nTPM (vital, limit 1); urinary bladder: 26.5 nTPM (protected, limit 2); thyroid gland: 26.1 nTPM (manageable, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 2); stomach: 22.5 nTPM (protected, limit 2); spleen: 22.2 nTPM (manageable, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); thymus: 20.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 2); salivary gland: 17.9 nTPM (protected, limit 2); esophagus: 15.3 nTPM (protected, limit 2); duodenum: 15.2 nTPM (vital, limit 1); skin: 14.7 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000174446,SNAPC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.34426,-0.412281,-0.581233
True,compatible,,True,True,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000174448,STARD6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.7654% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.7654% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7654% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.7654% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7654% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.7654% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7654% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.3855% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000174448,STARD6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0261446
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.7654% (minimum 99%, Missing); basal ganglia: 98.7654% (minimum 99%, Missing); cerebral cortex: 98.7654% (minimum 99%, Missing); hippocampal formation: 98.7654% (minimum 99%, Missing); hypothalamus: 98.7654% (minimum 99%, Missing); midbrain: 98.7654% (minimum 99%, Missing); retina: 98.7654% (minimum 99%, Missing); spinal cord: 96.3855% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000174448,STARD6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0261446
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.1,0.1,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin,ENSG00000174450,GOLGA6L2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 97.8389% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.1,0.1,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin,ENSG00000174450,GOLGA6L2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,0.047996,0.027996,-0.011611
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 97.8389% (minimum 99%, Missing)",0,80,unavailable,1.1,0.1,0.1,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin,ENSG00000174450,GOLGA6L2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,0.047996,0.027996,-0.011611
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,24.2,36.7,26.4,"parathyroid gland: 36.7 nTPM (protected, limit 2); thyroid gland: 26.4 nTPM (manageable, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); pituitary gland: 17.4 nTPM (vital, limit 1); hypothalamus: 16.6 nTPM (vital, limit 1); salivary gland: 16.3 nTPM (protected, limit 2); urinary bladder: 14.9 nTPM (protected, limit 2); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.3 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); tongue: 7.9 nTPM (protected, limit 2); skeletal muscle: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); rectum: 7.1 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 2); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000174483,BBS1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.6542% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.6778% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.9558% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.5272% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.9060% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 52.8265% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 57.4153% (minimum 99%, Baseline (adaptation disabled)); colon: 60.8989% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.8955% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.6983% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 73.4417% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.5238% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.0137% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.7698% (minimum 99%, Baseline (adaptation disabled)); liver: 79.9410% (minimum 99%, Baseline (adaptation disabled)); lung: 72.8495% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.4237% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.2620% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.5810% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 42.4765% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 60.8989% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.2398% (minimum 97%, Baseline (adaptation disabled)); retina: 56.5762% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.4424% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.6504% (minimum 99%, Baseline (adaptation disabled)); skin: 74.4505% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.8619% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.5848% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.8619% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.1212% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.9136% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.8736% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.6542% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.4286% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.5238% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,24.2,36.7,26.4,"parathyroid gland: 36.7 nTPM (protected, limit 2); thyroid gland: 26.4 nTPM (manageable, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); pituitary gland: 17.4 nTPM (vital, limit 1); hypothalamus: 16.6 nTPM (vital, limit 1); salivary gland: 16.3 nTPM (protected, limit 2); urinary bladder: 14.9 nTPM (protected, limit 2); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.3 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); tongue: 7.9 nTPM (protected, limit 2); skeletal muscle: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); rectum: 7.1 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 2); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000174483,BBS1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.443458,-0.545235,-0.461735
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.6542% (minimum 95%, Uncertain); adrenal gland: 64.6778% (minimum 99%, Missing); amygdala: 59.9558% (minimum 99%, Missing); basal ganglia: 54.5272% (minimum 99%, Missing); bone marrow: 90.3333% (minimum 99%, Uncertain); cerebellum: 57.9060% (minimum 99%, Uncertain); cerebral cortex: 52.8265% (minimum 99%, Uncertain); choroid plexus: 57.4153% (minimum 99%, Missing); colon: 60.8989% (minimum 97%, Missing); duodenum: 80.8955% (minimum 99%, Missing); esophagus: 75.6983% (minimum 97%, Uncertain); heart muscle: 73.4417% (minimum 99%, Missing); hippocampal formation: 64.5238% (minimum 99%, Missing); hypothalamus: 62.0137% (minimum 99%, Missing); kidney: 53.7698% (minimum 99%, Missing); liver: 79.9410% (minimum 99%, Missing); lung: 72.8495% (minimum 99%, Uncertain); lymph node: 84.4237% (minimum 97%, Uncertain); midbrain: 68.2620% (minimum 99%, Missing); pancreas: 67.5810% (minimum 99%, Missing); parathyroid gland: 42.4765% (minimum 97%, Missing); pituitary gland: 60.8989% (minimum 99%, Missing); rectum: 79.2398% (minimum 97%, Missing); retina: 56.5762% (minimum 99%, Missing); salivary gland: 62.4424% (minimum 97%, Uncertain); skeletal muscle: 77.6504% (minimum 99%, Uncertain); skin: 74.4505% (minimum 95%, Missing); small intestine: 74.8619% (minimum 99%, Missing); smooth muscle: 66.5848% (minimum 99%, Uncertain); spinal cord: 74.8619% (minimum 99%, Missing); spleen: 82.1212% (minimum 95%, Uncertain); stomach: 66.9136% (minimum 97%, Missing); thymus: 77.8736% (minimum 95%, Missing); thyroid gland: 50.6542% (minimum 95%, Missing); tongue: 77.4286% (minimum 97%, Missing); urinary bladder: 64.5238% (minimum 97%, Uncertain)",0,1,partial,24.2,36.7,26.4,"parathyroid gland: 36.7 nTPM (protected, limit 2); thyroid gland: 26.4 nTPM (manageable, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 2); pituitary gland: 17.4 nTPM (vital, limit 1); hypothalamus: 16.6 nTPM (vital, limit 1); salivary gland: 16.3 nTPM (protected, limit 2); urinary bladder: 14.9 nTPM (protected, limit 2); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 2); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.3 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 2); tongue: 7.9 nTPM (protected, limit 2); skeletal muscle: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); rectum: 7.1 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 2); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000174483,BBS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.443458,-0.545235,-0.461735
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,ENSG00000174527,MYO1H,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 90.0000% (minimum 95%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 81.8182% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 90.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,ENSG00000174527,MYO1H,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.05,0.03,-0.24
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 90.0000% (minimum 95%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); retina: 81.8182% (minimum 99%, Missing); thyroid gland: 90.0000% (minimum 95%, Missing)",0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,ENSG00000174527,MYO1H,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.05,0.03,-0.24
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,0,routine_complete,0.8,3.9,0.7,"salivary gland: 3.9 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,ENSG00000174562,KLK15,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.8947% (minimum 99%, Baseline (adaptation disabled)); colon: 33.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 55.0000% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 22.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 91.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.1111% (minimum 95%, Baseline (adaptation disabled))",0,0,routine_complete,0.8,3.9,0.7,"salivary gland: 3.9 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,ENSG00000174562,KLK15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.338889,-0.75,-0.411053
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.8947% (minimum 99%, Uncertain); colon: 33.3333% (minimum 97%, Uncertain); duodenum: 91.6667% (minimum 99%, Uncertain); kidney: 91.6667% (minimum 99%, Uncertain); pancreas: 91.6667% (minimum 99%, Uncertain); rectum: 55.0000% (minimum 97%, Uncertain); salivary gland: 22.0000% (minimum 97%, Uncertain); skin: 91.6667% (minimum 95%, Uncertain); thyroid gland: 61.1111% (minimum 95%, Uncertain)",0,0,routine_complete,0.8,3.9,0.7,"salivary gland: 3.9 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,ENSG00000174562,KLK15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.338889,-0.75,-0.411053
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000174667,OR7D4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 25.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 25.0000% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 50.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 50.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000174667,OR7D4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.45,0.03,-0.74
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 25.0000% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); retina: 25.0000% (minimum 99%, Missing); skeletal muscle: 50.0000% (minimum 99%, Missing); skin: 50.0000% (minimum 95%, Missing); small intestine: 50.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing)",0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000174667,OR7D4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.45,0.03,-0.74
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.1,0.9,0.4,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174776,WDR49,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8764% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.1287% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.4815% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.0189% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.7959% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.2430% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 49.1620% (minimum 99%, Baseline (adaptation disabled)); duodenum: 81.4815% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.7216% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.4815% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.2745% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.2793% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.7033% (minimum 99%, Baseline (adaptation disabled)); lung: 83.8095% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.7033% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7033% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.6237% (minimum 99%, Baseline (adaptation disabled)); small intestine: 67.1756% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.8764% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.2793% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,9.1,0.9,0.4,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174776,WDR49,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.00652174,-0.0627835,-0.49838
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8764% (minimum 99%, Missing); amygdala: 87.1287% (minimum 99%, Missing); basal ganglia: 81.4815% (minimum 99%, Missing); bone marrow: 83.0189% (minimum 99%, Missing); cerebellum: 89.7959% (minimum 99%, Missing); cerebral cortex: 82.2430% (minimum 99%, Missing); choroid plexus: 49.1620% (minimum 99%, Missing); duodenum: 81.4815% (minimum 99%, Missing); esophagus: 90.7216% (minimum 97%, Missing); heart muscle: 81.4815% (minimum 99%, Missing); hippocampal formation: 86.2745% (minimum 99%, Missing); hypothalamus: 79.2793% (minimum 99%, Missing); kidney: 96.7033% (minimum 99%, Missing); lung: 83.8095% (minimum 99%, Missing); lymph node: 96.7033% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 96.7033% (minimum 99%, Missing); pituitary gland: 94.6237% (minimum 99%, Missing); small intestine: 67.1756% (minimum 99%, Missing); smooth muscle: 98.8764% (minimum 99%, Missing); spinal cord: 79.2793% (minimum 99%, Missing)",0,80,unavailable,9.1,0.9,0.4,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174776,WDR49,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.00652174,-0.0627835,-0.49838
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,116.2,15.8,6.8,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); salivary gland: 15.8 nTPM (protected, limit 2); kidney: 7.8 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174788,PCP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5573% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.7257% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.4701% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.8246% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.1149% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.3054% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.3390% (minimum 99%, Baseline (adaptation disabled)); liver: 96.8113% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0269% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.4585% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.8246% (minimum 99%, Baseline (adaptation disabled)); retina: 77.1893% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.3701% (minimum 97%, Baseline (adaptation disabled)); skin: 94.1430% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.5573% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.3752% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,116.2,15.8,6.8,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); salivary gland: 15.8 nTPM (protected, limit 2); kidney: 7.8 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174788,PCP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0085702,-0.096299,-0.505299
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5573% (minimum 99%, Missing); bone marrow: 96.7257% (minimum 99%, Missing); cerebellum: 48.4701% (minimum 99%, Missing); duodenum: 98.8246% (minimum 99%, Missing); heart muscle: 98.1149% (minimum 99%, Missing); hypothalamus: 94.3054% (minimum 99%, Missing); kidney: 93.3390% (minimum 99%, Missing); liver: 96.8113% (minimum 99%, Missing); lung: 98.0269% (minimum 99%, Missing); pancreas: 95.4585% (minimum 99%, Missing); pituitary gland: 98.8246% (minimum 99%, Missing); retina: 77.1893% (minimum 99%, Missing); salivary gland: 87.3701% (minimum 97%, Missing); skin: 94.1430% (minimum 95%, Missing); small intestine: 98.5573% (minimum 99%, Missing); spinal cord: 95.3752% (minimum 99%, Missing)",0,80,unavailable,116.2,15.8,6.8,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); salivary gland: 15.8 nTPM (protected, limit 2); kidney: 7.8 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174788,PCP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0085702,-0.096299,-0.505299
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,21,15.4,16.2,"retina: 21 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); lymph node: 15.4 nTPM (protected, limit 2); skeletal muscle: 15 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); heart muscle: 14 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 2); tongue: 13 nTPM (protected, limit 2); small intestine: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); duodenum: 12.1 nTPM (vital, limit 1); liver: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 2); cerebellum: 11.4 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 2); smooth muscle: 10.3 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); kidney: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 2); pituitary gland: 9.2 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174796,THAP6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.6422% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.5439% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.9308% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.3814% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.0704% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 66.9565% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.0704% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.0405% (minimum 99%, Baseline (adaptation disabled)); colon: 70.6422% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.6250% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.0769% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.2642% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.1096% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.1096% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.6422% (minimum 99%, Baseline (adaptation disabled)); liver: 65.6250% (minimum 99%, Baseline (adaptation disabled)); lung: 71.7391% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.2575% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.5669% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.5170% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.9565% (minimum 97%, Baseline (adaptation disabled)); retina: 52.3810% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.9889% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.6299% (minimum 99%, Baseline (adaptation disabled)); skin: 58.7786% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.5251% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.1617% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.7391% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.2542% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.5460% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.1875% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.6299% (minimum 95%, Baseline (adaptation disabled)); tongue: 63.9889% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.1875% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,21,15.4,16.2,"retina: 21 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); lymph node: 15.4 nTPM (protected, limit 2); skeletal muscle: 15 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); heart muscle: 14 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 2); tongue: 13 nTPM (protected, limit 2); small intestine: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); duodenum: 12.1 nTPM (vital, limit 1); liver: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 2); cerebellum: 11.4 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 2); smooth muscle: 10.3 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); kidney: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 2); pituitary gland: 9.2 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174796,THAP6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.362214,-0.37,-0.46619
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.6422% (minimum 95%, Missing); adrenal gland: 67.5439% (minimum 99%, Missing); amygdala: 79.9308% (minimum 99%, Missing); basal ganglia: 79.3814% (minimum 99%, Missing); bone marrow: 65.0704% (minimum 99%, Missing); cerebellum: 66.9565% (minimum 99%, Missing); cerebral cortex: 65.0704% (minimum 99%, Missing); choroid plexus: 78.0405% (minimum 99%, Missing); colon: 70.6422% (minimum 97%, Missing); duodenum: 65.6250% (minimum 99%, Missing); esophagus: 71.0769% (minimum 97%, Missing); heart muscle: 62.2642% (minimum 99%, Missing); hippocampal formation: 79.1096% (minimum 99%, Missing); hypothalamus: 79.1096% (minimum 99%, Missing); kidney: 70.6422% (minimum 99%, Missing); liver: 65.6250% (minimum 99%, Missing); lung: 71.7391% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 77.2575% (minimum 99%, Missing); pancreas: 73.5669% (minimum 99%, Missing); parathyroid gland: 66.0000% (minimum 97%, Missing); pituitary gland: 71.5170% (minimum 99%, Missing); rectum: 66.9565% (minimum 97%, Missing); retina: 52.3810% (minimum 99%, Missing); salivary gland: 63.9889% (minimum 97%, Missing); skeletal muscle: 60.6299% (minimum 99%, Missing); skin: 58.7786% (minimum 95%, Missing); small intestine: 64.5251% (minimum 99%, Missing); smooth muscle: 69.1617% (minimum 99%, Missing); spinal cord: 71.7391% (minimum 99%, Missing); spleen: 65.2542% (minimum 95%, Missing); stomach: 68.5460% (minimum 97%, Missing); thymus: 72.1875% (minimum 95%, Missing); thyroid gland: 60.6299% (minimum 95%, Missing); tongue: 63.9889% (minimum 97%, Missing); urinary bladder: 72.1875% (minimum 97%, Missing)",0,80,unavailable,21,15.4,16.2,"retina: 21 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); lymph node: 15.4 nTPM (protected, limit 2); skeletal muscle: 15 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); heart muscle: 14 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 2); tongue: 13 nTPM (protected, limit 2); small intestine: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); duodenum: 12.1 nTPM (vital, limit 1); liver: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 2); cerebellum: 11.4 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 2); smooth muscle: 10.3 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); kidney: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 2); pituitary gland: 9.2 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174796,THAP6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.362214,-0.37,-0.46619
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,664.8,317.1,192.6,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 2); colon: 301.7 nTPM (protected, limit 2); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 2); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 2); salivary gland: 224.1 nTPM (protected, limit 2); urinary bladder: 202.5 nTPM (protected, limit 2); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (manageable, limit 5); spleen: 191.7 nTPM (manageable, limit 5); thyroid gland: 183.2 nTPM (manageable, limit 5); skin: 181.8 nTPM (manageable, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 2); parathyroid gland: 133.6 nTPM (protected, limit 2); duodenum: 121.1 nTPM (vital, limit 1); thymus: 117.3 nTPM (manageable, limit 5); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 2); retina: 30.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174886,NDUFA11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.4670% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 34.7028% (minimum 99%, Baseline (adaptation disabled)); amygdala: 42.7055% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 46.9055% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 58.6691% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.1533% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 45.3856% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 44.9067% (minimum 99%, Baseline (adaptation disabled)); colon: 42.3136% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.6320% (minimum 99%, Baseline (adaptation disabled)); esophagus: 44.5541% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 24.9746% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 46.9951% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 44.5900% (minimum 99%, Baseline (adaptation disabled)); kidney: 43.9523% (minimum 99%, Baseline (adaptation disabled)); liver: 37.3502% (minimum 99%, Baseline (adaptation disabled)); lung: 59.5373% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.9810% (minimum 97%, Baseline (adaptation disabled)); midbrain: 42.8461% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.5528% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.3556% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 52.4656% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.3267% (minimum 97%, Baseline (adaptation disabled)); retina: 87.8175% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 49.6857% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 35.0214% (minimum 99%, Baseline (adaptation disabled)); skin: 54.8995% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.1046% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.9909% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 46.1715% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.5835% (minimum 95%, Baseline (adaptation disabled)); stomach: 47.6734% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.3574% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.7095% (minimum 95%, Baseline (adaptation disabled)); tongue: 41.1033% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.2180% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,664.8,317.1,192.6,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 2); colon: 301.7 nTPM (protected, limit 2); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 2); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 2); salivary gland: 224.1 nTPM (protected, limit 2); urinary bladder: 202.5 nTPM (protected, limit 2); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (manageable, limit 5); spleen: 191.7 nTPM (manageable, limit 5); thyroid gland: 183.2 nTPM (manageable, limit 5); skin: 181.8 nTPM (manageable, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 2); parathyroid gland: 133.6 nTPM (protected, limit 2); duodenum: 121.1 nTPM (vital, limit 1); thymus: 117.3 nTPM (manageable, limit 5); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 2); retina: 30.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174886,NDUFA11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.41533,-0.558967,-0.740254
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.4670% (minimum 95%, Missing); adrenal gland: 34.7028% (minimum 99%, Missing); amygdala: 42.7055% (minimum 99%, Missing); basal ganglia: 46.9055% (minimum 99%, Missing); bone marrow: 58.6691% (minimum 99%, Missing); cerebellum: 56.1533% (minimum 99%, Missing); cerebral cortex: 45.3856% (minimum 99%, Missing); choroid plexus: 44.9067% (minimum 99%, Missing); colon: 42.3136% (minimum 97%, Missing); duodenum: 64.6320% (minimum 99%, Missing); esophagus: 44.5541% (minimum 97%, Missing); heart muscle: 24.9746% (minimum 99%, Missing); hippocampal formation: 46.9951% (minimum 99%, Missing); hypothalamus: 44.5900% (minimum 99%, Missing); kidney: 43.9523% (minimum 99%, Missing); liver: 37.3502% (minimum 99%, Missing); lung: 59.5373% (minimum 99%, Missing); lymph node: 60.9810% (minimum 97%, Missing); midbrain: 42.8461% (minimum 99%, Missing); pancreas: 52.5528% (minimum 99%, Missing); parathyroid gland: 62.3556% (minimum 97%, Missing); pituitary gland: 52.4656% (minimum 99%, Missing); rectum: 80.3267% (minimum 97%, Missing); retina: 87.8175% (minimum 99%, Missing); salivary gland: 49.6857% (minimum 97%, Missing); skeletal muscle: 35.0214% (minimum 99%, Missing); skin: 54.8995% (minimum 95%, Missing); small intestine: 55.1046% (minimum 99%, Missing); smooth muscle: 71.9909% (minimum 99%, Missing); spinal cord: 46.1715% (minimum 99%, Missing); spleen: 53.5835% (minimum 95%, Missing); stomach: 47.6734% (minimum 97%, Missing); thymus: 65.3574% (minimum 95%, Missing); thyroid gland: 54.7095% (minimum 95%, Missing); tongue: 41.1033% (minimum 97%, Missing); urinary bladder: 52.2180% (minimum 97%, Missing)",0,80,unavailable,664.8,317.1,192.6,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 2); colon: 301.7 nTPM (protected, limit 2); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 2); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 2); salivary gland: 224.1 nTPM (protected, limit 2); urinary bladder: 202.5 nTPM (protected, limit 2); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (manageable, limit 5); spleen: 191.7 nTPM (manageable, limit 5); thyroid gland: 183.2 nTPM (manageable, limit 5); skin: 181.8 nTPM (manageable, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 2); parathyroid gland: 133.6 nTPM (protected, limit 2); duodenum: 121.1 nTPM (vital, limit 1); thymus: 117.3 nTPM (manageable, limit 5); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 2); retina: 30.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000174886,NDUFA11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.41533,-0.558967,-0.740254
True,compatible,,True,True,False,,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000174898,CATSPERD,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000174898,CATSPERD,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000174898,CATSPERD,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000175018,TEX36,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"smooth muscle: 98.4848% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000175018,TEX36,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0385932,0.0223664,-0.00515152
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"smooth muscle: 98.4848% (minimum 99%, Missing)",0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000175018,TEX36,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0385932,0.0223664,-0.00515152
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,20,8.3,8.6,"bone marrow: 20 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 2); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); retina: 4.4 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); esophagus: 3.3 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000175073,VCPIP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.1111% (minimum 99%, Baseline (adaptation disabled)); amygdala: 66.2651% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.4762% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 21.5686% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.4762% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 49.1071% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.4648% (minimum 99%, Baseline (adaptation disabled)); colon: 56.1224% (minimum 97%, Baseline (adaptation disabled)); duodenum: 59.7826% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.2651% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.7059% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.2651% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.7010% (minimum 99%, Baseline (adaptation disabled)); liver: 44.7154% (minimum 99%, Baseline (adaptation disabled)); lung: 57.8947% (minimum 99%, Baseline (adaptation disabled)); lymph node: 39.8551% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.2651% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.5106% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.4587% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.5714% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.5106% (minimum 97%, Baseline (adaptation disabled)); retina: 55.5556% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.2917% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 51.8868% (minimum 99%, Baseline (adaptation disabled)); skin: 63.2184% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.1111% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.2184% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.9012% (minimum 99%, Baseline (adaptation disabled)); spleen: 39.0071% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.5556% (minimum 97%, Baseline (adaptation disabled)); thymus: 51.4019% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.2917% (minimum 95%, Baseline (adaptation disabled)); tongue: 51.8868% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.8947% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,20,8.3,8.6,"bone marrow: 20 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 2); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); retina: 4.4 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); esophagus: 3.3 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000175073,VCPIP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.559929,-0.571449,-0.774314
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 95%, Missing); adrenal gland: 61.1111% (minimum 99%, Missing); amygdala: 66.2651% (minimum 99%, Missing); basal ganglia: 65.4762% (minimum 99%, Missing); bone marrow: 21.5686% (minimum 99%, Missing); cerebellum: 65.4762% (minimum 99%, Missing); cerebral cortex: 49.1071% (minimum 99%, Missing); choroid plexus: 77.4648% (minimum 99%, Missing); colon: 56.1224% (minimum 97%, Missing); duodenum: 59.7826% (minimum 99%, Missing); esophagus: 62.5000% (minimum 97%, Missing); heart muscle: 66.2651% (minimum 99%, Missing); hippocampal formation: 64.7059% (minimum 99%, Missing); hypothalamus: 66.2651% (minimum 99%, Missing); kidney: 56.7010% (minimum 99%, Missing); liver: 44.7154% (minimum 99%, Missing); lung: 57.8947% (minimum 99%, Missing); lymph node: 39.8551% (minimum 97%, Missing); midbrain: 66.2651% (minimum 99%, Missing); pancreas: 58.5106% (minimum 99%, Missing); parathyroid gland: 50.4587% (minimum 97%, Missing); pituitary gland: 78.5714% (minimum 99%, Missing); rectum: 58.5106% (minimum 97%, Missing); retina: 55.5556% (minimum 99%, Missing); salivary gland: 57.2917% (minimum 97%, Missing); skeletal muscle: 51.8868% (minimum 99%, Missing); skin: 63.2184% (minimum 95%, Missing); small intestine: 61.1111% (minimum 99%, Missing); smooth muscle: 63.2184% (minimum 99%, Missing); spinal cord: 67.9012% (minimum 99%, Missing); spleen: 39.0071% (minimum 95%, Missing); stomach: 55.5556% (minimum 97%, Missing); thymus: 51.4019% (minimum 95%, Missing); thyroid gland: 57.2917% (minimum 95%, Missing); tongue: 51.8868% (minimum 97%, Missing); urinary bladder: 57.8947% (minimum 97%, Missing)",0,80,unavailable,20,8.3,8.6,"bone marrow: 20 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 2); liver: 6.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 2); thymus: 5.2 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 2); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); retina: 4.4 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 2); lung: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); esophagus: 3.3 nTPM (protected, limit 2); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000175073,VCPIP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.559929,-0.571449,-0.774314
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.4,0,146.4,"thymus: 146.4 nTPM (manageable, limit 5); thyroid gland: 23 nTPM (manageable, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; tonsil,ENSG00000175097,RAG2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 41.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.9091% (minimum 99%, Baseline (adaptation disabled)); thymus: 0.6784% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 4.1667% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.4,0,146.4,"thymus: 146.4 nTPM (manageable, limit 5); thyroid gland: 23 nTPM (manageable, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; tonsil,ENSG00000175097,RAG2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.943216,0.03,-0.573333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 41.6667% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); kidney: 90.9091% (minimum 99%, Missing); thymus: 0.6784% (minimum 95%, Missing); thyroid gland: 4.1667% (minimum 95%, Missing)",0,80,unavailable,1.4,0,146.4,"thymus: 146.4 nTPM (manageable, limit 5); thyroid gland: 23 nTPM (manageable, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; tonsil,ENSG00000175097,RAG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.943216,0.03,-0.573333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,10.7,5.8,6.6,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); salivary gland: 5.8 nTPM (protected, limit 2); esophagus: 5.7 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175106,TVP23C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 69.6721% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.0470% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.2759% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.5614% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 44.2708% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.5484% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.7037% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 56.2914% (minimum 99%, Baseline (adaptation disabled)); colon: 72.6496% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.1887% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.8592% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.5484% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.2479% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.6721% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.8231% (minimum 99%, Baseline (adaptation disabled)); liver: 69.1057% (minimum 99%, Baseline (adaptation disabled)); lung: 65.8915% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.8929% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.1057% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.9630% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.2479% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 46.4481% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.9524% (minimum 97%, Baseline (adaptation disabled)); retina: 68.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.4406% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 74.5614% (minimum 99%, Baseline (adaptation disabled)); skin: 66.4062% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.6721% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.1887% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.4328% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.8855% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.6721% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.5243% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.2914% (minimum 95%, Baseline (adaptation disabled)); tongue: 85.8586% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.1057% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,10.7,5.8,6.6,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); salivary gland: 5.8 nTPM (protected, limit 2); esophagus: 5.7 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175106,TVP23C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.387086,-0.375594,-0.547292
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 69.6721% (minimum 95%, Missing); adrenal gland: 57.0470% (minimum 99%, Uncertain); amygdala: 73.2759% (minimum 99%, Missing); basal ganglia: 74.5614% (minimum 99%, Missing); bone marrow: 44.2708% (minimum 99%, Missing); cerebellum: 68.5484% (minimum 99%, Missing); cerebral cortex: 78.7037% (minimum 99%, Missing); choroid plexus: 56.2914% (minimum 99%, Missing); colon: 72.6496% (minimum 97%, Missing); duodenum: 80.1887% (minimum 99%, Missing); esophagus: 59.8592% (minimum 97%, Missing); heart muscle: 68.5484% (minimum 99%, Missing); hippocampal formation: 70.2479% (minimum 99%, Missing); hypothalamus: 69.6721% (minimum 99%, Missing); kidney: 57.8231% (minimum 99%, Missing); liver: 69.1057% (minimum 99%, Uncertain); lung: 65.8915% (minimum 99%, Missing); lymph node: 75.8929% (minimum 97%, Missing); midbrain: 69.1057% (minimum 99%, Missing); pancreas: 62.9630% (minimum 99%, Missing); parathyroid gland: 70.2479% (minimum 97%, Uncertain); pituitary gland: 46.4481% (minimum 99%, Missing); rectum: 80.9524% (minimum 97%, Missing); retina: 68.0000% (minimum 99%, Missing); salivary gland: 59.4406% (minimum 97%, Missing); skeletal muscle: 74.5614% (minimum 99%, Uncertain); skin: 66.4062% (minimum 95%, Uncertain); small intestine: 69.6721% (minimum 99%, Missing); smooth muscle: 80.1887% (minimum 99%, Missing); spinal cord: 63.4328% (minimum 99%, Missing); spleen: 64.8855% (minimum 95%, Uncertain); stomach: 69.6721% (minimum 97%, Missing); thymus: 82.5243% (minimum 95%, Missing); thyroid gland: 56.2914% (minimum 95%, Missing); tongue: 85.8586% (minimum 97%, Missing); urinary bladder: 69.1057% (minimum 97%, Missing)",0,1,partial,10.7,5.8,6.6,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); salivary gland: 5.8 nTPM (protected, limit 2); esophagus: 5.7 nTPM (protected, limit 2); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); small intestine: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175106,TVP23C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.387086,-0.375594,-0.547292
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,21.6,0.4,0.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000175175,PPM1E,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 55.0847% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.2469% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 50.3876% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 34.9462% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.5882% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.4848% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 86.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 38.6905% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 54.1667% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.2778% (minimum 99%, Baseline (adaptation disabled)); liver: 86.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 97.0149% (minimum 99%, Baseline (adaptation disabled)); midbrain: 65.6566% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.5493% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.5882% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); retina: 23.1317% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.0149% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.5882% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.7126% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.2029% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,21.6,0.4,0.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000175175,PPM1E,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0201493,-0.027971,-0.758683
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 55.0847% (minimum 99%, Missing); amygdala: 65.0000% (minimum 99%, Missing); basal ganglia: 80.2469% (minimum 99%, Missing); cerebellum: 50.3876% (minimum 99%, Missing); cerebral cortex: 34.9462% (minimum 99%, Missing); choroid plexus: 95.5882% (minimum 99%, Missing); heart muscle: 86.6667% (minimum 98%, Approved); hippocampal formation: 38.6905% (minimum 99%, Missing); hypothalamus: 54.1667% (minimum 99%, Missing); kidney: 90.2778% (minimum 98%, Approved); liver: 86.6667% (minimum 98%, Approved); lung: 97.0149% (minimum 98%, Approved); midbrain: 65.6566% (minimum 99%, Missing); pancreas: 91.5493% (minimum 98%, Approved); parathyroid gland: 95.5882% (minimum 97%, Missing); pituitary gland: 83.3333% (minimum 99%, Missing); retina: 23.1317% (minimum 99%, Missing); small intestine: 97.0149% (minimum 98%, Approved); smooth muscle: 95.5882% (minimum 98%, Approved); spinal cord: 74.7126% (minimum 99%, Missing); stomach: 94.2029% (minimum 95%, Approved)",0,1,partial,21.6,0.4,0.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000175175,PPM1E,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0201493,-0.0141176,-0.758683
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,ENSG00000175202,HIGD2B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thyroid gland: 94.5946% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,ENSG00000175202,HIGD2B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,-0.00405405,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thyroid gland: 94.5946% (minimum 95%, Missing)",0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,ENSG00000175202,HIGD2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,-0.00405405,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,ENSG00000175294,CATSPER1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.1098% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6744% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,ENSG00000175294,CATSPER1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0324561,0.0240828,-0.0189017
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.1098% (minimum 99%, Missing); lung: 97.6744% (minimum 99%, Missing)",0,80,unavailable,0.5,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,ENSG00000175294,CATSPER1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0324561,0.0240828,-0.0189017
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,36.5,10.6,14.7,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 10.6 nTPM (protected, limit 2); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); retina: 5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175305,CCNE2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 88.1250% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.9184% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.0370% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.0370% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 27.8656% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.5031% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.8879% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.5753% (minimum 99%, Baseline (adaptation disabled)); colon: 72.6804% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.1136% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.8065% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.5584% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.9006% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.4545% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.5753% (minimum 99%, Baseline (adaptation disabled)); liver: 86.5031% (minimum 99%, Baseline (adaptation disabled)); lung: 89.2405% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.0850% (minimum 97%, Baseline (adaptation disabled)); midbrain: 72.3077% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.2405% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.5753% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.9184% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.9388% (minimum 97%, Baseline (adaptation disabled)); retina: 73.8220% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.6792% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.9184% (minimum 99%, Baseline (adaptation disabled)); skin: 71.2121% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.0492% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.0370% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 44.6203% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.9756% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.9583% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.8089% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.2703% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.5776% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,36.5,10.6,14.7,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 10.6 nTPM (protected, limit 2); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); retina: 5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175305,CCNE2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.460417,-0.39915,-0.711344
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 87.0370% (minimum 99%, Missing); basal ganglia: 87.0370% (minimum 99%, Missing); bone marrow: 27.8656% (minimum 99%, Missing); cerebellum: 86.5031% (minimum 99%, Missing); cerebral cortex: 65.8879% (minimum 99%, Missing); choroid plexus: 96.5753% (minimum 99%, Missing); colon: 72.6804% (minimum 97%, Missing); duodenum: 80.1136% (minimum 99%, Missing); esophagus: 75.8065% (minimum 97%, Missing); heart muscle: 91.5584% (minimum 95%, Enhanced); hippocampal formation: 77.9006% (minimum 99%, Missing); hypothalamus: 85.4545% (minimum 99%, Missing); liver: 86.5031% (minimum 95%, Enhanced); lung: 89.2405% (minimum 99%, Missing); lymph node: 57.0850% (minimum 97%, Missing); midbrain: 72.3077% (minimum 99%, Missing); pancreas: 89.2405% (minimum 95%, Enhanced); pituitary gland: 95.9184% (minimum 99%, Missing); rectum: 71.9388% (minimum 97%, Missing); retina: 73.8220% (minimum 99%, Missing); skin: 71.2121% (minimum 95%, Missing); small intestine: 77.0492% (minimum 99%, Missing); smooth muscle: 87.0370% (minimum 95%, Enhanced); spinal cord: 44.6203% (minimum 99%, Missing); stomach: 78.3333% (minimum 97%, Missing); thymus: 48.9583% (minimum 95%, Missing); tongue: 95.2703% (minimum 97%, Missing); urinary bladder: 87.5776% (minimum 97%, Missing)",0,1,partial,36.5,10.6,14.7,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 10.6 nTPM (protected, limit 2); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 2); retina: 5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175305,CCNE2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.460417,-0.39915,-0.711344
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,8,partial,9.4,6.4,2.1,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 2); parathyroid gland: 6.2 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175344,CHRNA7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 88.8889% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 24.2424% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.5882% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.7586% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.7273% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.5366% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 38.7097% (minimum 99%, Baseline (adaptation disabled)); colon: 63.1579% (minimum 97%, Baseline (adaptation disabled)); duodenum: 35.8209% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.3077% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.8140% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.7143% (minimum 99%, Baseline (adaptation disabled)); liver: 96.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 82.7586% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.0638% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 27.9070% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.5882% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.1739% (minimum 97%, Baseline (adaptation disabled)); retina: 48.9796% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.7586% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); skin: 88.8889% (minimum 95%, Baseline (adaptation disabled)); small intestine: 20.3390% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 27.2727% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.7143% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.1579% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,9.4,6.4,2.1,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 2); parathyroid gland: 6.2 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175344,CHRNA7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.416667,-0.697273,-0.78661
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 24.2424% (minimum 99%, Missing); amygdala: 70.5882% (minimum 99%, Missing); basal ganglia: 82.7586% (minimum 99%, Missing); bone marrow: 72.7273% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 99%, Missing); cerebral cortex: 58.5366% (minimum 99%, Missing); choroid plexus: 38.7097% (minimum 99%, Missing); colon: 63.1579% (minimum 97%, Missing); duodenum: 35.8209% (minimum 99%, Missing); esophagus: 92.3077% (minimum 97%, Missing); heart muscle: 85.7143% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 55.8140% (minimum 99%, Missing); kidney: 85.7143% (minimum 99%, Missing); liver: 96.0000% (minimum 99%, Missing); lung: 82.7586% (minimum 95%, Enhanced); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 51.0638% (minimum 99%, Missing); parathyroid gland: 27.9070% (minimum 97%, Missing); pituitary gland: 70.5882% (minimum 99%, Missing); rectum: 52.1739% (minimum 97%, Missing); retina: 48.9796% (minimum 99%, Missing); salivary gland: 82.7586% (minimum 97%, Missing); skeletal muscle: 85.7143% (minimum 99%, Missing); skin: 88.8889% (minimum 95%, Missing); small intestine: 20.3390% (minimum 99%, Missing); smooth muscle: 85.7143% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 27.2727% (minimum 97%, Missing); thymus: 85.7143% (minimum 95%, Missing); thyroid gland: 53.3333% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 63.1579% (minimum 97%, Missing)",0,8,partial,9.4,6.4,2.1,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 2); parathyroid gland: 6.2 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175344,CHRNA7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.416667,-0.697273,-0.78661
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,17.6,2.9,4.7,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); cerebellum: 2.8 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175449,RFESD,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.3972% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.1481% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.0690% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 40.3390% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.9524% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.1481% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 86.8613% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.2000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.7778% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.1481% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.2319% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.2168% (minimum 99%, Baseline (adaptation disabled)); liver: 84.3972% (minimum 99%, Baseline (adaptation disabled)); lung: 89.4737% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.8613% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.3972% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.2727% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.2168% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 81.5068% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.2481% (minimum 97%, Baseline (adaptation disabled)); retina: 83.8028% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.4054% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 72.1212% (minimum 99%, Baseline (adaptation disabled)); skin: 71.6867% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.5385% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.9677% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.6389% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.8028% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.2168% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.9524% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.8613% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.9524% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.3972% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,17.6,2.9,4.7,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); cerebellum: 2.8 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175449,RFESD,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.233133,-0.165946,-0.58661
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Uncertain); adrenal gland: 84.3972% (minimum 99%, Missing); amygdala: 88.1481% (minimum 99%, Missing); basal ganglia: 82.0690% (minimum 99%, Missing); bone marrow: 40.3390% (minimum 99%, Uncertain); cerebellum: 80.9524% (minimum 99%, Missing); cerebral cortex: 88.1481% (minimum 99%, Missing); choroid plexus: 85.0000% (minimum 99%, Missing); colon: 86.8613% (minimum 97%, Missing); duodenum: 95.2000% (minimum 99%, Missing); esophagus: 87.5000% (minimum 97%, Missing); heart muscle: 77.7778% (minimum 99%, Missing); hippocampal formation: 88.1481% (minimum 99%, Missing); hypothalamus: 86.2319% (minimum 99%, Missing); kidney: 83.2168% (minimum 99%, Missing); liver: 84.3972% (minimum 99%, Missing); lung: 89.4737% (minimum 99%, Missing); lymph node: 86.8613% (minimum 97%, Missing); midbrain: 84.3972% (minimum 99%, Missing); pancreas: 77.2727% (minimum 99%, Missing); parathyroid gland: 83.2168% (minimum 97%, Missing); pituitary gland: 81.5068% (minimum 99%, Missing); rectum: 92.2481% (minimum 97%, Missing); retina: 83.8028% (minimum 99%, Missing); salivary gland: 80.4054% (minimum 97%, Missing); skeletal muscle: 72.1212% (minimum 99%, Missing); skin: 71.6867% (minimum 95%, Missing); small intestine: 91.5385% (minimum 99%, Missing); smooth muscle: 95.9677% (minimum 99%, Missing); spinal cord: 82.6389% (minimum 99%, Missing); spleen: 83.8028% (minimum 95%, Missing); stomach: 83.2168% (minimum 97%, Missing); thymus: 80.9524% (minimum 95%, Missing); thyroid gland: 86.8613% (minimum 95%, Missing); tongue: 80.9524% (minimum 97%, Missing); urinary bladder: 84.3972% (minimum 97%, Missing)",0,1,partial,17.6,2.9,4.7,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); cerebellum: 2.8 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175449,RFESD,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.233133,-0.165946,-0.58661
True,compatible,,True,True,False,,0,80,unavailable,0.7,0,0.2,,,0,not_established,not_triggered,,,ENSG00000175513,TSGA10IP,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 93.2692% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.0980% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9796% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0,0.2,,,0,not_established,not_triggered,,,ENSG00000175513,TSGA10IP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.029798,0.03,-0.0573077
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 93.2692% (minimum 99%, Missing); hypothalamus: 95.0980% (minimum 99%, Missing); spinal cord: 98.9796% (minimum 99%, Missing)",0,80,unavailable,0.7,0,0.2,,,0,not_established,not_triggered,,,ENSG00000175513,TSGA10IP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.029798,0.03,-0.0573077
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.3,0.7,1.4,"kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000175518,UBQLNL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7848% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.0952% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.9627% (minimum 99%, Baseline (adaptation disabled)); liver: 97.1698% (minimum 99%, Baseline (adaptation disabled)); lung: 97.4763% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0952% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.4076% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.4763% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.3,0.7,1.4,"kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000175518,UBQLNL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00665635,0.0078481,-0.0303727
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7848% (minimum 99%, Missing); heart muscle: 98.0952% (minimum 99%, Missing); kidney: 95.9627% (minimum 99%, Missing); liver: 97.1698% (minimum 99%, Missing); lung: 97.4763% (minimum 99%, Missing); pancreas: 98.0952% (minimum 99%, Missing); pituitary gland: 98.4076% (minimum 99%, Missing); small intestine: 97.4763% (minimum 99%, Missing)",0,80,unavailable,1.3,0.7,1.4,"kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000175518,UBQLNL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00665635,0.0078481,-0.0303727
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000175520,UBQLN3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000175520,UBQLN3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000175520,UBQLN3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,9,partial,7.8,6.8,2.9,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 2); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175536,LIPT2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.2256% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.3309% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.6031% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.2256% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.7500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.6031% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 85.7143% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.9231% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.9565% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.5522% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6031% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.6031% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.1707% (minimum 99%, Baseline (adaptation disabled)); liver: 79.4702% (minimum 99%, Baseline (adaptation disabled)); lung: 87.5912% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.1064% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.6031% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.0811% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.7143% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.1064% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.5070% (minimum 97%, Baseline (adaptation disabled)); retina: 86.3309% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.7143% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.6061% (minimum 99%, Baseline (adaptation disabled)); skin: 88.2353% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.4194% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.5522% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.7143% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.9221% (minimum 97%, Baseline (adaptation disabled)); thymus: 81.6327% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 80.5369% (minimum 95%, Baseline (adaptation disabled)); tongue: 63.8298% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.5912% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,7.8,6.8,2.9,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 2); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175536,LIPT2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.144631,-0.331702,-0.383939
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.2256% (minimum 95%, Missing); adrenal gland: 86.3309% (minimum 99%, Missing); amygdala: 91.6031% (minimum 99%, Missing); basal ganglia: 90.2256% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 99%, Missing); cerebellum: 93.7500% (minimum 99%, Missing); cerebral cortex: 91.6031% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 85.7143% (minimum 97%, Missing); duodenum: 76.9231% (minimum 99%, Missing); esophagus: 86.9565% (minimum 97%, Missing); heart muscle: 89.5522% (minimum 99%, Missing); hippocampal formation: 91.6031% (minimum 99%, Missing); hypothalamus: 91.6031% (minimum 99%, Missing); kidney: 73.1707% (minimum 99%, Missing); liver: 79.4702% (minimum 99%, Missing); lung: 87.5912% (minimum 99%, Missing); lymph node: 85.1064% (minimum 97%, Missing); midbrain: 91.6031% (minimum 99%, Missing); pancreas: 81.0811% (minimum 99%, Missing); parathyroid gland: 85.7143% (minimum 97%, Missing); pituitary gland: 85.1064% (minimum 99%, Missing); rectum: 84.5070% (minimum 97%, Missing); retina: 86.3309% (minimum 99%, Missing); salivary gland: 85.7143% (minimum 97%, Missing); skeletal muscle: 60.6061% (minimum 99%, Missing); skin: 88.2353% (minimum 95%, Missing); small intestine: 77.4194% (minimum 99%, Missing); smooth muscle: 96.0000% (minimum 99%, Missing); spinal cord: 89.5522% (minimum 99%, Missing); spleen: 85.7143% (minimum 90%, Approved); stomach: 77.9221% (minimum 97%, Missing); thymus: 81.6327% (minimum 95%, Missing); thyroid gland: 80.5369% (minimum 95%, Missing); tongue: 63.8298% (minimum 97%, Missing); urinary bladder: 87.5912% (minimum 97%, Missing)",0,9,partial,7.8,6.8,2.9,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 2); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); pituitary gland: 2.1 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175536,LIPT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.144631,-0.331702,-0.383939
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,8.8,4.5,4.5,"retina: 8.8 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175548,ALG10B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9351% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 59.5238% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.7458% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.3478% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.3651% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.7193% (minimum 99%, Baseline (adaptation disabled)); colon: 71.4286% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.5676% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.6269% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.4225% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.2069% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.7193% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.7284% (minimum 99%, Baseline (adaptation disabled)); liver: 58.1395% (minimum 99%, Baseline (adaptation disabled)); lung: 67.5676% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.6316% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.2069% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.1026% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.8235% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 81.9672% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 36.2319% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.9351% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.1250% (minimum 99%, Baseline (adaptation disabled)); skin: 54.3478% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.5676% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.9672% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.6316% (minimum 95%, Baseline (adaptation disabled)); stomach: 58.1395% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.1798% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.5556% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.4932% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.1250% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,8.8,4.5,4.5,"retina: 8.8 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175548,ALG10B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.423684,-0.443684,-0.627681
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9351% (minimum 90%, Approved); adrenal gland: 59.5238% (minimum 99%, Missing); amygdala: 84.7458% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 54.3478% (minimum 99%, Missing); cerebellum: 79.3651% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 87.7193% (minimum 99%, Missing); colon: 71.4286% (minimum 97%, Missing); duodenum: 67.5676% (minimum 99%, Missing); esophagus: 74.6269% (minimum 97%, Missing); heart muscle: 70.4225% (minimum 99%, Missing); hippocampal formation: 86.2069% (minimum 99%, Missing); hypothalamus: 87.7193% (minimum 99%, Missing); kidney: 61.7284% (minimum 99%, Missing); liver: 58.1395% (minimum 99%, Missing); lung: 67.5676% (minimum 99%, Missing); lymph node: 52.6316% (minimum 97%, Missing); midbrain: 86.2069% (minimum 99%, Missing); pancreas: 64.1026% (minimum 99%, Missing); parathyroid gland: 58.8235% (minimum 97%, Missing); pituitary gland: 81.9672% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 36.2319% (minimum 99%, Missing); salivary gland: 64.9351% (minimum 97%, Missing); skeletal muscle: 78.1250% (minimum 99%, Missing); skin: 54.3478% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); smooth muscle: 67.5676% (minimum 99%, Missing); spinal cord: 81.9672% (minimum 99%, Missing); spleen: 52.6316% (minimum 95%, Missing); stomach: 58.1395% (minimum 97%, Missing); thymus: 56.1798% (minimum 95%, Missing); thyroid gland: 55.5556% (minimum 95%, Missing); tongue: 68.4932% (minimum 97%, Missing); urinary bladder: 78.1250% (minimum 97%, Missing)",0,1,partial,8.8,4.5,4.5,"retina: 8.8 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 2); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175548,ALG10B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.423684,-0.443684,-0.627681
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,5.6,2.3,4.2,"pituitary gland: 1.9 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000175646,PRM1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,5.6,2.3,4.2,"skeletal muscle: 5.6 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); adrenal gland: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000175646,PRM1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.049694,0.0298324,0.00959209
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,5.6,2.3,4.2,"pituitary gland: 1.9 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000175646,PRM1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00986156
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.6,0,0.1,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000175664,TEX26,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.1221% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.8716% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3036% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.3134% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.3077% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.0082% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.7593% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.5701% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.7593% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,11.6,0,0.1,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000175664,TEX26,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0452381,0.03,-0.346923
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.1221% (minimum 99%, Missing); amygdala: 95.8716% (minimum 99%, Missing); basal ganglia: 93.3036% (minimum 99%, Missing); cerebral cortex: 96.3134% (minimum 99%, Missing); choroid plexus: 64.3077% (minimum 99%, Missing); hippocampal formation: 95.0000% (minimum 99%, Missing); hypothalamus: 86.0082% (minimum 99%, Missing); midbrain: 96.7593% (minimum 99%, Missing); pituitary gland: 94.5701% (minimum 99%, Missing); spinal cord: 96.7593% (minimum 99%, Missing)",0,80,unavailable,11.6,0,0.1,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000175664,TEX26,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0452381,0.03,-0.346923
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1,0.6,0,,,0,not_established,not_triggered,,,ENSG00000175699,CCDC197,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"heart muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 88.6364% (minimum 99%, Baseline (adaptation disabled)); tongue: 92.8571% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1,0.6,0,,,0,not_established,not_triggered,,,ENSG00000175699,CCDC197,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,-0.0414286,-0.103636
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"heart muscle: 92.8571% (minimum 99%, Missing); skeletal muscle: 88.6364% (minimum 99%, Missing); tongue: 92.8571% (minimum 97%, Missing)",0,80,unavailable,1,0.6,0,,,0,not_established,not_triggered,,,ENSG00000175699,CCDC197,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,-0.0414286,-0.103636
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000175718,RBMXL3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000175718,RBMXL3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000175718,RBMXL3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,26.5,9.9,4.5,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 2); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 2); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 2); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 4); stomach: 4.1 nTPM (protected, limit 2); rectum: 4 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 2); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000175764,TTLL11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.1592% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.0058% (minimum 99%, Baseline (adaptation disabled)); amygdala: 57.5610% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.7065% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.7218% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.9218% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 52.6786% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.2381% (minimum 99%, Baseline (adaptation disabled)); colon: 54.3779% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.5175% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.1016% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.2381% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 51.3043% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.7660% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.2721% (minimum 99%, Baseline (adaptation disabled)); liver: 69.4118% (minimum 99%, Baseline (adaptation disabled)); lung: 75.1592% (minimum 99%, Baseline (adaptation disabled)); lymph node: 82.5175% (minimum 97%, Baseline (adaptation disabled)); midbrain: 47.3896% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.2381% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 72.3926% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.2721% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.6835% (minimum 97%, Baseline (adaptation disabled)); retina: 64.1304% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.0843% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 30.8094% (minimum 99%, Baseline (adaptation disabled)); skin: 72.3926% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.1946% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.6604% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 35.1190% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.1242% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.2138% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.8219% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 77.6316% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.1281% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.2081% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,26.5,9.9,4.5,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 2); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 2); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 2); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 2); stomach: 4.1 nTPM (protected, limit 2); rectum: 4 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000175764,TTLL11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.226074,-0.426221,-0.681906
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.1592% (minimum 90%, Approved); adrenal gland: 69.0058% (minimum 99%, Missing); amygdala: 57.5610% (minimum 99%, Missing); basal ganglia: 58.7065% (minimum 99%, Missing); bone marrow: 88.7218% (minimum 99%, Missing); cerebellum: 65.9218% (minimum 99%, Missing); cerebral cortex: 52.6786% (minimum 99%, Missing); choroid plexus: 70.2381% (minimum 99%, Missing); colon: 54.3779% (minimum 97%, Missing); duodenum: 82.5175% (minimum 99%, Missing); esophagus: 63.1016% (minimum 97%, Missing); heart muscle: 70.2381% (minimum 99%, Missing); hippocampal formation: 51.3043% (minimum 99%, Missing); hypothalamus: 62.7660% (minimum 99%, Missing); kidney: 80.2721% (minimum 99%, Missing); liver: 69.4118% (minimum 99%, Missing); lung: 75.1592% (minimum 98%, Approved); lymph node: 82.5175% (minimum 95%, Approved); midbrain: 47.3896% (minimum 99%, Missing); pancreas: 70.2381% (minimum 99%, Missing); parathyroid gland: 72.3926% (minimum 95%, Approved); pituitary gland: 80.2721% (minimum 99%, Missing); rectum: 74.6835% (minimum 97%, Missing); retina: 64.1304% (minimum 99%, Missing); salivary gland: 71.0843% (minimum 97%, Missing); skeletal muscle: 30.8094% (minimum 99%, Missing); skin: 72.3926% (minimum 95%, Missing); small intestine: 79.1946% (minimum 99%, Missing); smooth muscle: 55.6604% (minimum 99%, Missing); spinal cord: 35.1190% (minimum 99%, Missing); spleen: 77.1242% (minimum 95%, Missing); stomach: 74.2138% (minimum 97%, Missing); thymus: 80.8219% (minimum 95%, Missing); thyroid gland: 77.6316% (minimum 95%, Missing); tongue: 58.1281% (minimum 97%, Missing); urinary bladder: 68.2081% (minimum 97%, Missing)",0,2,partial,26.5,9.9,4.5,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 2); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 2); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 2); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 2); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 4); stomach: 4.1 nTPM (protected, limit 2); rectum: 4 nTPM (protected, limit 2); lung: 3.9 nTPM (vital, limit 2); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000175764,TTLL11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.226074,-0.426221,-0.681906
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,5.9,5.8,5.9,"spleen: 5.9 nTPM (manageable, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 2); hippocampal formation: 4.7 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); skeletal muscle: 4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); salivary gland: 3.8 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175787,ZNF169,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1975% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.7701% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.5217% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.4146% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 46.8468% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 49.0566% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.2394% (minimum 99%, Baseline (adaptation disabled)); colon: 55.3191% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 67.5325% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.5325% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 52.5253% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.6506% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.0909% (minimum 99%, Baseline (adaptation disabled)); liver: 71.2329% (minimum 99%, Baseline (adaptation disabled)); lung: 62.6506% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.2727% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.6506% (minimum 99%, Baseline (adaptation disabled)); pancreas: 61.9048% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.2703% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 50.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 57.1429% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.7778% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 56.5217% (minimum 99%, Baseline (adaptation disabled)); skin: 51.4851% (minimum 95%, Baseline (adaptation disabled)); small intestine: 48.5981% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.8228% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.7701% (minimum 99%, Baseline (adaptation disabled)); spleen: 46.8468% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.1429% (minimum 97%, Baseline (adaptation disabled)); thymus: 59.0909% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.5253% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.3623% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,5.9,5.8,5.9,"spleen: 5.9 nTPM (manageable, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 2); hippocampal formation: 4.7 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); skeletal muscle: 4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); salivary gland: 3.8 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175787,ZNF169,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.481532,-0.497273,-0.521532
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1975% (minimum 95%, Missing); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 59.7701% (minimum 99%, Missing); basal ganglia: 56.5217% (minimum 99%, Missing); bone marrow: 63.4146% (minimum 99%, Missing); cerebellum: 46.8468% (minimum 99%, Missing); cerebral cortex: 49.0566% (minimum 99%, Missing); choroid plexus: 73.2394% (minimum 99%, Missing); colon: 55.3191% (minimum 97%, Missing); duodenum: 65.0000% (minimum 99%, Missing); esophagus: 67.5325% (minimum 97%, Missing); heart muscle: 67.5325% (minimum 99%, Missing); hippocampal formation: 52.5253% (minimum 99%, Missing); hypothalamus: 62.6506% (minimum 99%, Missing); kidney: 59.0909% (minimum 99%, Missing); liver: 71.2329% (minimum 99%, Missing); lung: 62.6506% (minimum 99%, Missing); lymph node: 47.2727% (minimum 97%, Missing); midbrain: 62.6506% (minimum 99%, Missing); pancreas: 61.9048% (minimum 99%, Missing); parathyroid gland: 70.2703% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 50.0000% (minimum 97%, Missing); retina: 57.1429% (minimum 99%, Missing); salivary gland: 57.7778% (minimum 97%, Missing); skeletal muscle: 56.5217% (minimum 99%, Missing); skin: 51.4851% (minimum 95%, Missing); small intestine: 48.5981% (minimum 99%, Missing); smooth muscle: 65.8228% (minimum 99%, Missing); spinal cord: 59.7701% (minimum 99%, Missing); spleen: 46.8468% (minimum 95%, Missing); stomach: 57.1429% (minimum 97%, Missing); thymus: 59.0909% (minimum 95%, Missing); thyroid gland: 52.5253% (minimum 95%, Missing); tongue: 75.3623% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",0,3,partial,5.9,5.8,5.9,"spleen: 5.9 nTPM (manageable, limit 5); cerebellum: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 2); hippocampal formation: 4.7 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 2); skeletal muscle: 4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); salivary gland: 3.8 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); parathyroid gland: 2.2 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000175787,ZNF169,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.481532,-0.497273,-0.521532
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000175809,CBLL2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000175809,CBLL2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000175809,CBLL2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000175820,CCDC168,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 98.8506% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000175820,CCDC168,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00149425
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 98.8506% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000175820,CCDC168,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00149425
True,compatible,,True,True,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000175877,TMEM270,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000175877,TMEM270,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.00603699
True,compatible,,True,True,True,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000175877,TMEM270,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.00603699
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.3,1,2.9,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176020,AMIGO3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.9130% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.9524% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.9130% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 53.1250% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.4444% (minimum 99%, Baseline (adaptation disabled)); colon: 77.2727% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.9524% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.3846% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.3846% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.9630% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.9130% (minimum 99%, Baseline (adaptation disabled)); liver: 48.5714% (minimum 99%, Baseline (adaptation disabled)); lung: 65.3846% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.2727% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.9524% (minimum 99%, Baseline (adaptation disabled)); pancreas: 53.1250% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 36.1702% (minimum 99%, Baseline (adaptation disabled)); retina: 94.4444% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.3846% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 34.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 36.9565% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.8333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.9130% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.9630% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.9630% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 77.2727% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.3,1,2.9,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176020,AMIGO3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.580435,-0.34037,-0.65
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.9130% (minimum 95%, Missing); adrenal gland: 68.0000% (minimum 99%, Missing); amygdala: 80.9524% (minimum 99%, Missing); basal ganglia: 73.9130% (minimum 99%, Missing); bone marrow: 53.1250% (minimum 99%, Missing); cerebellum: 68.0000% (minimum 99%, Missing); cerebral cortex: 85.0000% (minimum 99%, Missing); choroid plexus: 94.4444% (minimum 99%, Missing); colon: 77.2727% (minimum 97%, Missing); duodenum: 80.9524% (minimum 99%, Missing); esophagus: 65.3846% (minimum 97%, Missing); heart muscle: 65.3846% (minimum 99%, Missing); hippocampal formation: 85.0000% (minimum 99%, Missing); hypothalamus: 62.9630% (minimum 99%, Missing); kidney: 73.9130% (minimum 99%, Missing); liver: 48.5714% (minimum 99%, Missing); lung: 65.3846% (minimum 99%, Missing); lymph node: 77.2727% (minimum 97%, Missing); midbrain: 80.9524% (minimum 99%, Missing); pancreas: 53.1250% (minimum 99%, Missing); pituitary gland: 36.1702% (minimum 99%, Missing); retina: 94.4444% (minimum 99%, Missing); salivary gland: 65.3846% (minimum 97%, Missing); skeletal muscle: 34.0000% (minimum 99%, Missing); skin: 36.9565% (minimum 95%, Missing); small intestine: 70.8333% (minimum 99%, Missing); spinal cord: 73.9130% (minimum 99%, Missing); spleen: 62.9630% (minimum 95%, Missing); stomach: 62.9630% (minimum 97%, Missing); thymus: 85.0000% (minimum 95%, Missing); thyroid gland: 68.0000% (minimum 95%, Missing); urinary bladder: 77.2727% (minimum 97%, Missing)",0,80,unavailable,3.3,1,2.9,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176020,AMIGO3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.580435,-0.34037,-0.65
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,ENSG00000176040,TMPRSS7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 86.6667% (minimum 99%, Baseline (adaptation disabled)); duodenum: 92.8571% (minimum 99%, Baseline (adaptation disabled)); lung: 92.8571% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.6667% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.8571% (minimum 99%, Baseline (adaptation disabled)); skin: 92.8571% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.6667% (minimum 99%, Baseline (adaptation disabled)); stomach: 86.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.8571% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,ENSG00000176040,TMPRSS7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.0833333,-0.103333,-0.123333
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 86.6667% (minimum 99%, Missing); duodenum: 92.8571% (minimum 99%, Missing); lung: 92.8571% (minimum 99%, Missing); pancreas: 86.6667% (minimum 99%, Missing); pituitary gland: 92.8571% (minimum 99%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 86.6667% (minimum 99%, Missing); stomach: 86.6667% (minimum 97%, Missing); thymus: 86.6667% (minimum 95%, Missing); thyroid gland: 92.8571% (minimum 95%, Missing)",0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,ENSG00000176040,TMPRSS7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.0833333,-0.103333,-0.123333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,4.6,9.8,2.8,"salivary gland: 9.8 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000176083,ZNF683,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 97.6687% (minimum 99%, Baseline (adaptation disabled)); lung: 94.5368% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.0380% (minimum 97%, Baseline (adaptation disabled)); spinal cord: 98.0296% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.0193% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,4.6,9.8,2.8,"salivary gland: 9.8 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000176083,ZNF683,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.0160194,-0.0796197,-0.0446318
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 97.6687% (minimum 99%, Uncertain); lung: 94.5368% (minimum 99%, Missing); salivary gland: 89.0380% (minimum 97%, Missing); spinal cord: 98.0296% (minimum 99%, Missing); stomach: 96.0193% (minimum 97%, Missing)",0,2,partial,4.6,9.8,2.8,"salivary gland: 9.8 nTPM (protected, limit 2); lung: 4.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000176083,ZNF683,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;da Silva 2017,0.0160194,-0.0796197,-0.0446318
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,10,partial,12.2,7,7.4,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 2); hypothalamus: 5.5 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); lymph node: 4.8 nTPM (protected, limit 2); esophagus: 4.7 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 2); lung: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); liver: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); tongue: 3.9 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000176148,TCP11L1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.7132% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.1197% (minimum 99%, Baseline (adaptation disabled)); amygdala: 58.6207% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.1509% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.2270% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.1983% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 35.7895% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.7619% (minimum 99%, Baseline (adaptation disabled)); colon: 50.3704% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.5433% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.1304% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.1770% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 56.1983% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.2846% (minimum 99%, Baseline (adaptation disabled)); kidney: 54.4000% (minimum 99%, Baseline (adaptation disabled)); liver: 63.5514% (minimum 99%, Baseline (adaptation disabled)); lung: 60.1770% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.6207% (minimum 97%, Baseline (adaptation disabled)); midbrain: 51.9084% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.2846% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.5514% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.1197% (minimum 99%, Baseline (adaptation disabled)); rectum: 49.2754% (minimum 97%, Baseline (adaptation disabled)); retina: 53.9683% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.6207% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 70.1031% (minimum 99%, Baseline (adaptation disabled)); skin: 56.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 44.1558% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 44.7368% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 51.1278% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.3853% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.8873% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.6869% (minimum 95%, Baseline (adaptation disabled)); tongue: 63.5514% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.8387% (minimum 97%, Baseline (adaptation disabled))",0,10,partial,12.2,7,7.4,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 2); hypothalamus: 5.5 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); lymph node: 4.8 nTPM (protected, limit 2); esophagus: 4.7 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); liver: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); tongue: 3.9 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000176148,TCP11L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.471127,-0.477246,-0.632105
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.7132% (minimum 95%, Missing); adrenal gland: 58.1197% (minimum 99%, Missing); amygdala: 58.6207% (minimum 99%, Missing); basal ganglia: 64.1509% (minimum 99%, Missing); bone marrow: 48.2270% (minimum 99%, Missing); cerebellum: 56.1983% (minimum 99%, Missing); cerebral cortex: 35.7895% (minimum 99%, Missing); choroid plexus: 64.7619% (minimum 99%, Missing); colon: 50.3704% (minimum 97%, Missing); duodenum: 53.5433% (minimum 99%, Missing); esophagus: 59.1304% (minimum 97%, Missing); heart muscle: 60.1770% (minimum 98%, Approved); hippocampal formation: 56.1983% (minimum 99%, Missing); hypothalamus: 55.2846% (minimum 99%, Missing); kidney: 54.4000% (minimum 99%, Missing); liver: 63.5514% (minimum 99%, Missing); lung: 60.1770% (minimum 99%, Missing); lymph node: 58.6207% (minimum 97%, Missing); midbrain: 51.9084% (minimum 99%, Missing); pancreas: 55.2846% (minimum 99%, Missing); parathyroid gland: 63.5514% (minimum 97%, Missing); pituitary gland: 58.1197% (minimum 99%, Missing); rectum: 49.2754% (minimum 97%, Missing); retina: 53.9683% (minimum 99%, Missing); salivary gland: 58.6207% (minimum 97%, Missing); skeletal muscle: 70.1031% (minimum 98%, Approved); skin: 56.6667% (minimum 95%, Missing); small intestine: 44.1558% (minimum 99%, Missing); smooth muscle: 44.7368% (minimum 99%, Missing); spinal cord: 51.1278% (minimum 99%, Missing); spleen: 56.6667% (minimum 95%, Missing); stomach: 62.3853% (minimum 97%, Missing); thymus: 47.8873% (minimum 95%, Missing); thyroid gland: 68.6869% (minimum 95%, Missing); tongue: 63.5514% (minimum 97%, Missing); urinary bladder: 54.8387% (minimum 97%, Missing)",0,10,partial,12.2,7,7.4,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 2); colon: 6.7 nTPM (protected, limit 2); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 2); hypothalamus: 5.5 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); lymph node: 4.8 nTPM (protected, limit 2); esophagus: 4.7 nTPM (protected, limit 2); heart muscle: 4.5 nTPM (vital, limit 2); lung: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); liver: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); tongue: 3.9 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000176148,TCP11L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.471127,-0.477246,-0.632105
True,compatible,,True,True,False,,0,2,partial,0.4,1.1,0.8,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000176160,HSF5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.4,1.1,0.8,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000176160,HSF5,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.033368,0.00727273,0.00161426
True,compatible,,True,True,True,,0,2,partial,0.4,1.1,0.8,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000176160,HSF5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.033368,0.03,0.0078903
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,20.6,0.5,3,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000176165,FOXG1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 20.2128% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 16.8889% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.4359% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 15.5738% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.4762% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.0000% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 19.7917% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.2951% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.3721% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.4359% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 58.4615% (minimum 99%, Baseline (adaptation disabled)); retina: 92.6829% (minimum 99%, Baseline (adaptation disabled)); thymus: 55.8824% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,20.6,0.5,3,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000176165,FOXG1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.391176,-0.0862791,-0.834262
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 20.2128% (minimum 99%, Missing); basal ganglia: 16.8889% (minimum 99%, Missing); cerebellum: 97.4359% (minimum 99%, Missing); cerebral cortex: 15.5738% (minimum 99%, Missing); choroid plexus: 90.4762% (minimum 99%, Missing); esophagus: 95.0000% (minimum 97%, Missing); hippocampal formation: 19.7917% (minimum 99%, Missing); hypothalamus: 62.2951% (minimum 99%, Missing); lymph node: 88.3721% (minimum 97%, Missing); midbrain: 97.4359% (minimum 99%, Missing); pituitary gland: 58.4615% (minimum 99%, Missing); retina: 92.6829% (minimum 99%, Missing); thymus: 55.8824% (minimum 95%, Missing)",0,80,unavailable,20.6,0.5,3,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000176165,FOXG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.391176,-0.0862791,-0.834262
True,compatible,,True,True,False,,0,80,unavailable,0.9,0.6,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000176177,ENTHD1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 92.2414% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.6903% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.1667% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.9,0.6,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000176177,ENTHD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0583333,-0.0230973,-0.0675862
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 92.2414% (minimum 99%, Missing); lymph node: 94.6903% (minimum 97%, Missing); thymus: 89.1667% (minimum 95%, Missing)",0,80,unavailable,0.9,0.6,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000176177,ENTHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0583333,-0.0230973,-0.0675862
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176198,OR11H4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176198,OR11H4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176198,OR11H4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12.2,3.5,5.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 3.5 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176208,ATAD5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.0769% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.6087% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.3636% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.6087% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 13.4752% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 51.3514% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 61.2903% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.5758% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.3750% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.6087% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.3636% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.6087% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.3636% (minimum 99%, Baseline (adaptation disabled)); liver: 79.1667% (minimum 99%, Baseline (adaptation disabled)); lung: 73.0769% (minimum 99%, Baseline (adaptation disabled)); lymph node: 35.1852% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.3636% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.1667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.3636% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 79.1667% (minimum 99%, Baseline (adaptation disabled)); rectum: 55.8824% (minimum 97%, Baseline (adaptation disabled)); retina: 44.1860% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.0769% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.6087% (minimum 99%, Baseline (adaptation disabled)); skin: 44.1860% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.3750% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.6087% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.3750% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.5172% (minimum 97%, Baseline (adaptation disabled)); thymus: 26.7606% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 79.1667% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,12.2,3.5,5.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 3.5 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176208,ATAD5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.682394,-0.618148,-0.855248
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.0769% (minimum 95%, Missing); adrenal gland: 82.6087% (minimum 99%, Missing); amygdala: 86.3636% (minimum 99%, Missing); basal ganglia: 82.6087% (minimum 99%, Missing); bone marrow: 13.4752% (minimum 99%, Missing); cerebellum: 51.3514% (minimum 99%, Missing); cerebral cortex: 76.0000% (minimum 99%, Missing); choroid plexus: 95.0000% (minimum 99%, Missing); colon: 61.2903% (minimum 97%, Missing); duodenum: 57.5758% (minimum 99%, Missing); esophagus: 59.3750% (minimum 97%, Missing); heart muscle: 82.6087% (minimum 99%, Missing); hippocampal formation: 86.3636% (minimum 99%, Missing); hypothalamus: 82.6087% (minimum 99%, Missing); kidney: 86.3636% (minimum 99%, Missing); liver: 79.1667% (minimum 99%, Missing); lung: 73.0769% (minimum 99%, Missing); lymph node: 35.1852% (minimum 97%, Missing); midbrain: 86.3636% (minimum 99%, Missing); pancreas: 79.1667% (minimum 99%, Missing); parathyroid gland: 86.3636% (minimum 97%, Missing); pituitary gland: 79.1667% (minimum 99%, Missing); rectum: 55.8824% (minimum 97%, Missing); retina: 44.1860% (minimum 99%, Missing); salivary gland: 73.0769% (minimum 97%, Missing); skeletal muscle: 82.6087% (minimum 99%, Missing); skin: 44.1860% (minimum 95%, Missing); small intestine: 59.3750% (minimum 99%, Missing); smooth muscle: 76.0000% (minimum 99%, Missing); spinal cord: 82.6087% (minimum 99%, Missing); spleen: 59.3750% (minimum 95%, Missing); stomach: 65.5172% (minimum 97%, Missing); thymus: 26.7606% (minimum 95%, Missing); thyroid gland: 79.1667% (minimum 95%, Missing); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 76.0000% (minimum 97%, Missing)",0,80,unavailable,12.2,3.5,5.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 3.5 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176208,ATAD5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.682394,-0.618148,-0.855248
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176219,OR11H6,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176219,OR11H6,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176219,OR11H6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,4,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000176256,HMGB4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000176256,HMGB4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00972315
True,compatible,,True,True,True,,0,4,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000176256,HMGB4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.5,0,,,0,not_established,not_triggered,,,ENSG00000176294,OR4N2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 88.0952% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.3684% (minimum 99%, Baseline (adaptation disabled)); tongue: 88.0952% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.5,0,,,0,not_established,not_triggered,,,ENSG00000176294,OR4N2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.0890476,-0.109048
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 88.0952% (minimum 99%, Missing); heart muscle: 97.3684% (minimum 99%, Missing); tongue: 88.0952% (minimum 97%, Missing)",0,80,unavailable,0.5,0.5,0,,,0,not_established,not_triggered,,,ENSG00000176294,OR4N2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.0890476,-0.109048
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176299,OR4M1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176299,OR4M1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176299,OR4M1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000176302,FOXR1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 97.6190% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000176302,FOXR1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0261905,0.03,-0.0138095
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 97.6190% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000176302,FOXR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0261905,0.03,-0.0138095
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,15.9,3.6,3.6,"cerebellum: 15.9 nTPM (vital, limit 2); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000176401,EID2B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.4932% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.8235% (minimum 99%, Baseline (adaptation disabled)); amygdala: 37.0370% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 29.7619% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.3651% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 23.9234% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 31.0559% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 49.5050% (minimum 99%, Baseline (adaptation disabled)); colon: 58.1395% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.3651% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.6452% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.2911% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 39.0625% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 27.0270% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 70.4225% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.9756% (minimum 97%, Baseline (adaptation disabled)); midbrain: 47.1698% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.1250% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.5294% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 33.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.7458% (minimum 97%, Baseline (adaptation disabled)); retina: 35.2113% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.3651% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); skin: 84.7458% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.5676% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.9231% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 51.5464% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.2410% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.4638% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.1395% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.6452% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.2911% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,15.9,3.6,3.6,"cerebellum: 15.9 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000176401,EID2B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.368605,-0.388605,-0.750766
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.4932% (minimum 90%, Approved); adrenal gland: 58.8235% (minimum 99%, Missing); amygdala: 37.0370% (minimum 99%, Missing); basal ganglia: 29.7619% (minimum 99%, Missing); bone marrow: 79.3651% (minimum 98%, Approved); cerebellum: 23.9234% (minimum 98%, Approved); cerebral cortex: 31.0559% (minimum 99%, Missing); choroid plexus: 49.5050% (minimum 99%, Missing); colon: 58.1395% (minimum 97%, Missing); duodenum: 79.3651% (minimum 99%, Missing); esophagus: 80.6452% (minimum 95%, Approved); heart muscle: 63.2911% (minimum 99%, Missing); hippocampal formation: 39.0625% (minimum 99%, Missing); hypothalamus: 27.0270% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 83.3333% (minimum 98%, Approved); lung: 70.4225% (minimum 99%, Missing); lymph node: 60.9756% (minimum 95%, Approved); midbrain: 47.1698% (minimum 99%, Missing); pancreas: 78.1250% (minimum 99%, Missing); parathyroid gland: 73.5294% (minimum 95%, Approved); pituitary gland: 33.3333% (minimum 99%, Missing); rectum: 84.7458% (minimum 97%, Missing); retina: 35.2113% (minimum 99%, Missing); salivary gland: 79.3651% (minimum 95%, Approved); skeletal muscle: 71.4286% (minimum 98%, Approved); skin: 84.7458% (minimum 95%, Missing); small intestine: 67.5676% (minimum 99%, Missing); smooth muscle: 76.9231% (minimum 99%, Missing); spinal cord: 51.5464% (minimum 99%, Missing); spleen: 60.2410% (minimum 90%, Approved); stomach: 72.4638% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 58.1395% (minimum 95%, Missing); tongue: 80.6452% (minimum 97%, Missing); urinary bladder: 63.2911% (minimum 97%, Missing)",0,7,partial,15.9,3.6,3.6,"cerebellum: 15.9 nTPM (vital, limit 2); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000176401,EID2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.368605,-0.388605,-0.740766
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,3.2,0.3,"stomach: 3.2 nTPM (protected, limit 2); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000176563,CNTD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.5612% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.3934% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.4789% (minimum 99%, Baseline (adaptation disabled)); lung: 98.7981% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.6247% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.8042% (minimum 97%, Baseline (adaptation disabled)); spinal cord: 98.3254% (minimum 99%, Baseline (adaptation disabled)); stomach: 92.7765% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.5,3.2,0.3,"stomach: 3.2 nTPM (protected, limit 2); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000176563,CNTD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0427536,-0.0422348,-0.0252113
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.5612% (minimum 99%, Missing); cerebral cortex: 97.3934% (minimum 99%, Missing); kidney: 96.4789% (minimum 99%, Missing); lung: 98.7981% (minimum 99%, Missing); pancreas: 97.6247% (minimum 99%, Missing); rectum: 95.8042% (minimum 97%, Missing); spinal cord: 98.3254% (minimum 99%, Missing); stomach: 92.7765% (minimum 97%, Missing)",0,80,unavailable,1.5,3.2,0.3,"stomach: 3.2 nTPM (protected, limit 2); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000176563,CNTD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0427536,-0.0422348,-0.0252113
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000176566,DCAF4L2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000176566,DCAF4L2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000176566,DCAF4L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000176571,CNBD1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.2308% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000176571,CNBD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.00769231,0.01,-0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.0000% (minimum 99%, Missing); spleen: 94.2308% (minimum 95%, Missing)",0,80,unavailable,0.1,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000176571,CNBD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.00769231,0.01,-0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,75.7,36.3,11.5,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 2); urinary bladder: 23.3 nTPM (protected, limit 2); colon: 21.9 nTPM (protected, limit 2); rectum: 19 nTPM (protected, limit 2); lung: 14.5 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); stomach: 11 nTPM (protected, limit 2); skin: 10 nTPM (manageable, limit 5); salivary gland: 9.8 nTPM (protected, limit 2); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.2 nTPM (vital, limit 1); skeletal muscle: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000176597,B3GNT5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.8153% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.3503% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.4516% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.4516% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 15.0393% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.3662% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.2086% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.5817% (minimum 99%, Baseline (adaptation disabled)); colon: 37.9603% (minimum 97%, Baseline (adaptation disabled)); duodenum: 26.5347% (minimum 99%, Baseline (adaptation disabled)); esophagus: 26.9618% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.7619% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.8101% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.2298% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.8235% (minimum 99%, Baseline (adaptation disabled)); liver: 80.7229% (minimum 99%, Baseline (adaptation disabled)); lung: 48.0287% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.4138% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.7160% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.0485% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.7619% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.5263% (minimum 99%, Baseline (adaptation disabled)); rectum: 41.3580% (minimum 97%, Baseline (adaptation disabled)); retina: 92.4138% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.7586% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.0485% (minimum 99%, Baseline (adaptation disabled)); skin: 57.2650% (minimum 95%, Baseline (adaptation disabled)); small intestine: 24.7232% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.3367% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.7062% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.9180% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.4231% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 72.4324% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.7062% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 36.5123% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,75.7,36.3,11.5,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 2); urinary bladder: 23.3 nTPM (protected, limit 2); colon: 21.9 nTPM (protected, limit 2); rectum: 19 nTPM (protected, limit 2); lung: 14.5 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); stomach: 11 nTPM (protected, limit 2); skin: 10 nTPM (manageable, limit 5); salivary gland: 9.8 nTPM (protected, limit 2); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.2 nTPM (vital, limit 1); skeletal muscle: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000176597,B3GNT5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.411847,-0.700382,-0.839607
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.8153% (minimum 95%, Uncertain); adrenal gland: 85.3503% (minimum 99%, Missing); amygdala: 86.4516% (minimum 99%, Missing); basal ganglia: 86.4516% (minimum 99%, Missing); bone marrow: 15.0393% (minimum 99%, Missing); cerebellum: 94.3662% (minimum 99%, Missing); cerebral cortex: 82.2086% (minimum 99%, Missing); choroid plexus: 87.5817% (minimum 99%, Missing); colon: 37.9603% (minimum 97%, Missing); duodenum: 26.5347% (minimum 99%, Missing); esophagus: 26.9618% (minimum 97%, Missing); heart muscle: 79.7619% (minimum 99%, Missing); hippocampal formation: 84.8101% (minimum 99%, Missing); hypothalamus: 83.2298% (minimum 99%, Missing); kidney: 78.8235% (minimum 99%, Missing); liver: 80.7229% (minimum 99%, Missing); lung: 48.0287% (minimum 99%, Missing); lymph node: 92.4138% (minimum 97%, Missing); midbrain: 82.7160% (minimum 99%, Missing); pancreas: 65.0485% (minimum 99%, Missing); parathyroid gland: 79.7619% (minimum 97%, Missing); pituitary gland: 70.5263% (minimum 99%, Missing); rectum: 41.3580% (minimum 97%, Uncertain); retina: 92.4138% (minimum 99%, Missing); salivary gland: 57.7586% (minimum 97%, Uncertain); skeletal muscle: 65.0485% (minimum 99%, Uncertain); skin: 57.2650% (minimum 95%, Missing); small intestine: 24.7232% (minimum 99%, Missing); smooth muscle: 67.3367% (minimum 99%, Missing); spinal cord: 75.7062% (minimum 99%, Missing); spleen: 89.3333% (minimum 95%, Missing); stomach: 54.9180% (minimum 97%, Missing); thymus: 64.4231% (minimum 95%, Missing); thyroid gland: 72.4324% (minimum 95%, Missing); tongue: 75.7062% (minimum 97%, Missing); urinary bladder: 36.5123% (minimum 97%, Missing)",0,1,partial,75.7,36.3,11.5,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 2); urinary bladder: 23.3 nTPM (protected, limit 2); colon: 21.9 nTPM (protected, limit 2); rectum: 19 nTPM (protected, limit 2); lung: 14.5 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); stomach: 11 nTPM (protected, limit 2); skin: 10 nTPM (manageable, limit 5); salivary gland: 9.8 nTPM (protected, limit 2); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.2 nTPM (vital, limit 1); skeletal muscle: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000176597,B3GNT5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.411847,-0.700382,-0.839607
True,compatible,,True,True,False,,0,4,partial,2.8,0.1,0.1,,,52,not_established,not_triggered,,,ENSG00000176635,HORMAD2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 88.8000% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,2.8,0.1,0.1,"liver: 2.8 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000176635,HORMAD2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0455157,0.0255157,-0.102
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 88.8000% (minimum 95%, Enhanced)",0,4,partial,2.8,0.1,0.1,,,52,not_established,not_triggered,,,ENSG00000176635,HORMAD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,-0.062
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176679,TGIF2LY,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176679,TGIF2LY,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176679,TGIF2LY,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,1,1.9,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176732,PFN4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.9950% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6233% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 96.4504% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.8708% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.9,1,1.9,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176732,PFN4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.026456,0.0174687,-0.0254957
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.9950% (minimum 99%, Missing); heart muscle: 98.5000% (minimum 99%, Missing); kidney: 98.6233% (minimum 99%, Missing); pituitary gland: 98.5000% (minimum 99%, Missing); retina: 96.4504% (minimum 99%, Missing); skeletal muscle: 98.8708% (minimum 99%, Missing)",0,80,unavailable,2.9,1,1.9,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176732,PFN4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.026456,0.0174687,-0.0254957
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,False,,0,3,unreliable,0,0,0,,kidney / proximal tubules (microvilli): Medium (Enhanced),57,not_established,not_triggered,,,ENSG00000176746,MAGEB6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0,3,unreliable,0,0,0,,kidney / proximal tubules (microvilli): Medium (Enhanced),57,not_established,not_triggered,,,ENSG00000176746,MAGEB6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0,3,unreliable,0,0,0,,kidney / proximal tubules (microvilli): Medium (Enhanced),57,not_established,not_triggered,,,ENSG00000176746,MAGEB6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.1,3.8,2,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176771,NCKAP5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.0435% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.3590% (minimum 99%, Baseline (adaptation disabled)); amygdala: 44.6154% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 41.4286% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.3158% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.7037% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.4167% (minimum 99%, Baseline (adaptation disabled)); colon: 72.5000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 43.2836% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 53.7037% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 40.8451% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 50.8772% (minimum 99%, Baseline (adaptation disabled)); kidney: 42.6471% (minimum 99%, Baseline (adaptation disabled)); liver: 42.6471% (minimum 99%, Baseline (adaptation disabled)); lung: 20.7143% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.0476% (minimum 97%, Baseline (adaptation disabled)); midbrain: 36.7089% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.3590% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.8571% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.2941% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.3590% (minimum 97%, Baseline (adaptation disabled)); retina: 38.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.1837% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.2941% (minimum 99%, Baseline (adaptation disabled)); skin: 59.1837% (minimum 95%, Baseline (adaptation disabled)); small intestine: 48.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.8788% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 37.1795% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.0435% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.0435% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.5556% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 76.3158% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.8571% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.2941% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.1,3.8,2,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176771,NCKAP5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.358163,-0.537164,-0.782857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.0435% (minimum 95%, Missing); adrenal gland: 74.3590% (minimum 99%, Missing); amygdala: 44.6154% (minimum 99%, Missing); basal ganglia: 41.4286% (minimum 99%, Missing); cerebellum: 76.3158% (minimum 99%, Missing); cerebral cortex: 53.7037% (minimum 99%, Missing); choroid plexus: 60.4167% (minimum 99%, Missing); colon: 72.5000% (minimum 97%, Missing); duodenum: 58.0000% (minimum 99%, Missing); esophagus: 43.2836% (minimum 97%, Missing); heart muscle: 53.7037% (minimum 99%, Missing); hippocampal formation: 40.8451% (minimum 99%, Missing); hypothalamus: 50.8772% (minimum 99%, Missing); kidney: 42.6471% (minimum 99%, Missing); liver: 42.6471% (minimum 99%, Missing); lung: 20.7143% (minimum 99%, Missing); lymph node: 69.0476% (minimum 97%, Missing); midbrain: 36.7089% (minimum 99%, Missing); pancreas: 74.3590% (minimum 99%, Missing); parathyroid gland: 82.8571% (minimum 97%, Missing); pituitary gland: 85.2941% (minimum 99%, Missing); rectum: 74.3590% (minimum 97%, Missing); retina: 38.6667% (minimum 99%, Missing); salivary gland: 59.1837% (minimum 97%, Missing); skeletal muscle: 85.2941% (minimum 99%, Missing); skin: 59.1837% (minimum 95%, Missing); small intestine: 48.3333% (minimum 99%, Missing); smooth muscle: 87.8788% (minimum 99%, Missing); spinal cord: 37.1795% (minimum 99%, Missing); spleen: 63.0435% (minimum 95%, Missing); stomach: 63.0435% (minimum 97%, Missing); thymus: 80.5556% (minimum 95%, Missing); thyroid gland: 76.3158% (minimum 95%, Missing); tongue: 82.8571% (minimum 97%, Missing); urinary bladder: 85.2941% (minimum 97%, Missing)",0,80,unavailable,11.1,3.8,2,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000176771,NCKAP5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.358163,-0.537164,-0.782857
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000176774,MAGEB18,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000176774,MAGEB18,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000176774,MAGEB18,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,2,partial,0,1.6,0,,,53,not_established,not_triggered,,,ENSG00000176782,DEFB104A,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,2,partial,0,1.6,0,,,53,not_established,not_triggered,,,ENSG00000176782,DEFB104A,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.028742,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,2,partial,0,1.6,0,,,53,not_established,not_triggered,,,ENSG00000176782,DEFB104A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176787,OR52E2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176787,OR52E2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176787,OR52E2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176895,OR51A7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176895,OR51A7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176895,OR51A7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176922,OR51S1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176922,OR51S1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000176922,OR51S1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.2,1.1,0.2,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000176927,EFCAB5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8095% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.8095% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 87.3684% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.6471% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.4023% (minimum 99%, Baseline (adaptation disabled)); colon: 91.2088% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.8095% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.5116% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6471% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8095% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.5116% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8095% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.4023% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.5116% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.2979% (minimum 97%, Baseline (adaptation disabled)); retina: 98.8095% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.8095% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.4023% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.6471% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8095% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.2,1.1,0.2,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000176927,EFCAB5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0264706,-0.0870213,-0.116316
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8095% (minimum 99%, Missing); basal ganglia: 98.8095% (minimum 99%, Missing); bone marrow: 87.3684% (minimum 99%, Missing); cerebellum: 97.6471% (minimum 99%, Missing); cerebral cortex: 95.4023% (minimum 99%, Missing); colon: 91.2088% (minimum 97%, Missing); duodenum: 98.8095% (minimum 99%, Missing); heart muscle: 96.5116% (minimum 99%, Missing); hippocampal formation: 97.6471% (minimum 99%, Missing); hypothalamus: 98.8095% (minimum 99%, Missing); kidney: 96.5116% (minimum 99%, Missing); lung: 98.8095% (minimum 99%, Missing); lymph node: 95.4023% (minimum 97%, Missing); midbrain: 96.5116% (minimum 99%, Missing); rectum: 88.2979% (minimum 97%, Missing); retina: 98.8095% (minimum 99%, Missing); skeletal muscle: 98.8095% (minimum 99%, Missing); small intestine: 95.4023% (minimum 99%, Missing); smooth muscle: 97.6471% (minimum 99%, Missing); spinal cord: 98.8095% (minimum 99%, Missing)",0,80,unavailable,1.2,1.1,0.2,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000176927,EFCAB5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0264706,-0.0870213,-0.116316
True,compatible,,True,True,False,,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000176979,TRIM60,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 93.7500% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000176979,TRIM60,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.0125,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 93.7500% (minimum 95%, Uncertain)",0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000176979,TRIM60,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,-0.0125,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000176988,FMR1NB,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000176988,FMR1NB,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.00823322
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000176988,FMR1NB,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.00823322
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,0,routine_complete,0,0.2,0,,,55,not_established,not_triggered,,,ENSG00000177023,DEFB104B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,unresolved,unresolved_reproductive_selectivity;existing_nomination_or_manual_review,True,True,True,,0,0,routine_complete,0,0.2,0,,,55,not_established,not_triggered,,,ENSG00000177023,DEFB104B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,unresolved,unresolved_reproductive_selectivity;existing_nomination_or_manual_review,True,True,True,,0,0,routine_complete,0,0.2,0,,,55,not_established,not_triggered,,,ENSG00000177023,DEFB104B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,15.6,1.9,1.7,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000177025,C19orf18,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.2256% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.9565% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.9565% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.5070% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.2381% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.7500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.9091% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 43.4783% (minimum 99%, Baseline (adaptation disabled)); colon: 86.3309% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.7500% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.2381% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.8563% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.9161% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 87.5912% (minimum 99%, Baseline (adaptation disabled)); lung: 92.3077% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.2381% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.7586% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.6031% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.0233% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.9494% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.7500% (minimum 97%, Baseline (adaptation disabled)); retina: 70.5882% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.4194% (minimum 99%, Baseline (adaptation disabled)); skin: 90.9091% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.6031% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.0233% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.9091% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.3077% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 87.5912% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.2353% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,15.6,1.9,1.7,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000177025,C19orf18,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0740876,-0.106691,-0.555217
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.2256% (minimum 95%, Missing); adrenal gland: 86.9565% (minimum 98%, Approved); amygdala: 86.9565% (minimum 99%, Missing); basal ganglia: 84.5070% (minimum 99%, Missing); bone marrow: 95.2381% (minimum 98%, Approved); cerebellum: 93.7500% (minimum 98%, Approved); cerebral cortex: 90.9091% (minimum 98%, Approved); choroid plexus: 43.4783% (minimum 99%, Missing); colon: 86.3309% (minimum 95%, Approved); duodenum: 93.7500% (minimum 98%, Approved); heart muscle: 71.8563% (minimum 98%, Approved); hippocampal formation: 83.9161% (minimum 99%, Missing); hypothalamus: 83.3333% (minimum 99%, Missing); kidney: 83.3333% (minimum 98%, Approved); liver: 87.5912% (minimum 98%, Approved); lung: 92.3077% (minimum 98%, Approved); midbrain: 82.7586% (minimum 99%, Missing); pancreas: 91.6031% (minimum 98%, Approved); parathyroid gland: 93.0233% (minimum 95%, Approved); pituitary gland: 75.9494% (minimum 99%, Missing); rectum: 93.7500% (minimum 95%, Approved); retina: 70.5882% (minimum 99%, Missing); salivary gland: 90.9091% (minimum 95%, Approved); skeletal muscle: 77.4194% (minimum 98%, Approved); small intestine: 91.6031% (minimum 98%, Approved); smooth muscle: 93.0233% (minimum 98%, Approved); spinal cord: 80.0000% (minimum 99%, Missing); stomach: 92.3077% (minimum 95%, Approved); thyroid gland: 87.5912% (minimum 95%, Missing); tongue: 96.0000% (minimum 97%, Missing); urinary bladder: 88.2353% (minimum 95%, Approved)",0,6,partial,15.6,1.9,1.7,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000177025,C19orf18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0740876,-0.0866906,-0.555217
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,16.1,10.9,8.6,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.3 nTPM (protected, limit 2); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); colon: 9.1 nTPM (protected, limit 2); thymus: 8.6 nTPM (manageable, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); urinary bladder: 8.1 nTPM (protected, limit 2); spleen: 8.1 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 2); stomach: 7.9 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); skin: 7.4 nTPM (manageable, limit 5); thyroid gland: 7.4 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); salivary gland: 6.2 nTPM (protected, limit 2); adipose tissue: 6.2 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000177058,SLC38A9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Bruggeman 2018;Bradley 2020,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.2314% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.4162% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.7815% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.8535% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.0792% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.0792% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.0596% (minimum 99%, Baseline (adaptation disabled)); colon: 85.9784% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.7358% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.3239% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.7815% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.6242% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.4673% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.7122% (minimum 99%, Baseline (adaptation disabled)); liver: 77.6078% (minimum 99%, Baseline (adaptation disabled)); lung: 87.8740% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.6582% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.9394% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.5444% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.4175% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.5763% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.5828% (minimum 97%, Baseline (adaptation disabled)); retina: 85.3211% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 88.2911% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.7106% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.1875% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.3110% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.3239% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.5981% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.6460% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.2911% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.7815% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.3239% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,16.1,10.9,8.6,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.3 nTPM (protected, limit 2); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); colon: 9.1 nTPM (protected, limit 2); thymus: 8.6 nTPM (manageable, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); urinary bladder: 8.1 nTPM (protected, limit 2); spleen: 8.1 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 2); stomach: 7.9 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); skin: 7.4 nTPM (manageable, limit 5); thyroid gland: 7.4 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); salivary gland: 6.2 nTPM (protected, limit 2); adipose tissue: 6.2 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000177058,SLC38A9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Bruggeman 2018;Bradley 2020,-0.0835404,-0.133418,-0.213922
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.0000% (minimum 95%, Uncertain); adrenal gland: 92.2314% (minimum 99%, Missing); amygdala: 94.4162% (minimum 99%, Missing); basal ganglia: 93.7815% (minimum 99%, Missing); bone marrow: 88.8535% (minimum 99%, Uncertain); cerebellum: 92.0792% (minimum 99%, Missing); cerebral cortex: 92.0792% (minimum 99%, Uncertain); choroid plexus: 95.0596% (minimum 99%, Missing); colon: 85.9784% (minimum 97%, Missing); duodenum: 87.7358% (minimum 99%, Missing); esophagus: 87.3239% (minimum 97%, Missing); heart muscle: 93.7815% (minimum 99%, Uncertain); hippocampal formation: 93.6242% (minimum 99%, Missing); hypothalamus: 93.4673% (minimum 99%, Missing); kidney: 88.7122% (minimum 99%, Uncertain); liver: 77.6078% (minimum 99%, Missing); lung: 87.8740% (minimum 99%, Uncertain); lymph node: 83.6582% (minimum 97%, Missing); midbrain: 93.9394% (minimum 99%, Missing); pancreas: 82.5444% (minimum 99%, Missing); parathyroid gland: 84.4175% (minimum 97%, Uncertain); pituitary gland: 94.5763% (minimum 99%, Missing); rectum: 85.5828% (minimum 97%, Missing); retina: 85.3211% (minimum 99%, Missing); salivary gland: 90.0000% (minimum 97%, Uncertain); skeletal muscle: 93.0000% (minimum 99%, Uncertain); skin: 88.2911% (minimum 95%, Missing); small intestine: 89.7106% (minimum 99%, Missing); smooth muscle: 87.1875% (minimum 99%, Uncertain); spinal cord: 93.3110% (minimum 99%, Missing); spleen: 87.3239% (minimum 95%, Uncertain); stomach: 87.5981% (minimum 97%, Uncertain); thymus: 86.6460% (minimum 95%, Missing); thyroid gland: 88.2911% (minimum 95%, Uncertain); tongue: 93.7815% (minimum 97%, Missing); urinary bladder: 87.3239% (minimum 97%, Uncertain)",0,7,partial,16.1,10.9,8.6,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 2); parathyroid gland: 10.3 nTPM (protected, limit 2); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); colon: 9.1 nTPM (protected, limit 2); thymus: 8.6 nTPM (manageable, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); urinary bladder: 8.1 nTPM (protected, limit 2); spleen: 8.1 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 2); stomach: 7.9 nTPM (protected, limit 2); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); skin: 7.4 nTPM (manageable, limit 5); thyroid gland: 7.4 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); salivary gland: 6.2 nTPM (protected, limit 2); adipose tissue: 6.2 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000177058,SLC38A9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,Bruggeman 2018;Bradley 2020,-0.0835404,-0.133418,-0.213922
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3,0.2,0.4,"liver: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000177138,FAM9B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2759% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 96.6102% (minimum 97%, Baseline (adaptation disabled)); hypothalamus: 98.2759% (minimum 99%, Baseline (adaptation disabled)); liver: 65.5172% (minimum 99%, Baseline (adaptation disabled)); lung: 98.2759% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.6102% (minimum 99%, Baseline (adaptation disabled)); retina: 98.2759% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.2759% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.6923% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.4426% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3,0.2,0.4,"liver: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000177138,FAM9B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0155738,-0.00389831,-0.334828
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2759% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); colon: 96.6102% (minimum 97%, Missing); hypothalamus: 98.2759% (minimum 99%, Missing); liver: 65.5172% (minimum 99%, Missing); lung: 98.2759% (minimum 99%, Missing); pancreas: 96.6102% (minimum 99%, Missing); retina: 98.2759% (minimum 99%, Missing); skeletal muscle: 98.2759% (minimum 99%, Missing); small intestine: 95.0000% (minimum 99%, Missing); smooth muscle: 87.6923% (minimum 99%, Missing); spleen: 93.4426% (minimum 95%, Missing)",0,80,unavailable,3,0.2,0.4,"liver: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000177138,FAM9B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0155738,-0.00389831,-0.334828
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000177143,CETN1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000177143,CETN1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000177143,CETN1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,3,3.5,1.3,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000177202,SPACA4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 97.5298% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.4468% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,3,3.5,1.3,"colon: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); small intestine: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2)",,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000177202,SPACA4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0387737,0.000338983,-0.0155319
True,compatible,,True,True,True,,0,1,partial,3,3.5,1.3,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,ENSG00000177202,SPACA4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,0,routine_complete,2.1,0.8,2.5,"lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000177272,KCNA3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 42.8571% (minimum 95%, Baseline (adaptation disabled)); amygdala: 50.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 25.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 33.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 37.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 33.3333% (minimum 97%, Baseline (adaptation disabled)); esophagus: 75.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 21.4286% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 12.5000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 60.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 42.8571% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 27.2727% (minimum 97%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 13.6364% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 10.7143% (minimum 95%, Baseline (adaptation disabled)); stomach: 42.8571% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 37.5000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,2.1,0.8,2.5,"lung: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000177272,KCNA3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.842857,-0.697273,-0.865
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 42.8571% (minimum 90%, Approved); amygdala: 50.0000% (minimum 99%, Missing); basal ganglia: 25.0000% (minimum 99%, Missing); cerebellum: 33.3333% (minimum 99%, Missing); cerebral cortex: 37.5000% (minimum 99%, Missing); colon: 33.3333% (minimum 95%, Approved); esophagus: 75.0000% (minimum 95%, Approved); heart muscle: 60.0000% (minimum 98%, Approved); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 21.4286% (minimum 99%, Missing); kidney: 60.0000% (minimum 98%, Approved); liver: 60.0000% (minimum 98%, Approved); lung: 12.5000% (minimum 98%, Approved); midbrain: 60.0000% (minimum 99%, Missing); pancreas: 75.0000% (minimum 98%, Approved); pituitary gland: 42.8571% (minimum 99%, Missing); salivary gland: 27.2727% (minimum 95%, Approved); skin: 75.0000% (minimum 90%, Approved); small intestine: 13.6364% (minimum 98%, Approved); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 10.7143% (minimum 90%, Approved); stomach: 42.8571% (minimum 95%, Approved); thyroid gland: 37.5000% (minimum 90%, Approved); urinary bladder: 60.0000% (minimum 95%, Approved)",0,0,routine_complete,2.1,0.8,2.5,"lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000177272,KCNA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.792857,-0.677273,-0.855
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000177294,FBXO39,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 97.3597% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000177294,FBXO39,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0399329,0.0199329,-0.0164026
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 97.3597% (minimum 99%, Missing)",0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000177294,FBXO39,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0399329,0.0199329,-0.0164026
True,compatible,,True,True,False,,0,2,partial,0.2,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000177324,BEND2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.2963% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.2,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000177324,BEND2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.012963,0.03,-0.027037
True,compatible,,True,True,True,,0,2,partial,0.2,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000177324,BEND2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000177398,UMODL1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 90.9091% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 90.9091% (minimum 99%, Baseline (adaptation disabled)); lung: 90.9091% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.9091% (minimum 97%, Baseline (adaptation disabled)); small intestine: 83.3333% (minimum 99%, Baseline (adaptation disabled)); thymus: 76.9231% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000177398,UMODL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.180769,-0.0609091,-0.156667
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 90.9091% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); liver: 90.9091% (minimum 99%, Missing); lung: 90.9091% (minimum 99%, Missing); lymph node: 90.9091% (minimum 97%, Missing); small intestine: 83.3333% (minimum 99%, Missing); thymus: 76.9231% (minimum 95%, Missing)",0,80,unavailable,0.2,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000177398,UMODL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.180769,-0.0609091,-0.156667
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.8,2.3,0,"stomach: 2.3 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,ENSG00000177414,UBE2U,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 97.6331% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8024% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.4844% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.8,2.3,0,"stomach: 2.3 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,ENSG00000177414,UBE2U,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,-0.0351558,-0.0136686
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 97.6331% (minimum 99%, Missing); kidney: 98.8024% (minimum 99%, Missing); stomach: 93.4844% (minimum 97%, Missing)",0,80,unavailable,0.8,2.3,0,"stomach: 2.3 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,ENSG00000177414,UBE2U,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,-0.0351558,-0.0136686
True,compatible,,True,True,False,,0,5,partial,0.5,0.3,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000177483,RBM44,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.8354% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.7097% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0769% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0769% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.7097% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.7097% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7097% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,0.5,0.3,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000177483,RBM44,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0307692,0.0107692,-0.0216456
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lung: 98.0769% (minimum 99%, Missing)",0,5,partial,0.5,0.3,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000177483,RBM44,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0107692,-0.00923077
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,1,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced),54,not_established,not_triggered,,,ENSG00000177504,VCX2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,1,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced),54,not_established,not_triggered,,,ENSG00000177504,VCX2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,1,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced),54,not_established,not_triggered,,,ENSG00000177504,VCX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000177558,FAM187B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000177558,FAM187B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0470149,0.03,0.00850523
True,compatible,,True,True,True,,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000177558,FAM187B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00850523
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; tonsil,ENSG00000177627,C12orf54,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.3,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; tonsil,ENSG00000177627,C12orf54,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0474293,0.0197959,0.00232737
True,compatible,,True,True,True,,0,80,unavailable,0.3,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; tonsil,ENSG00000177627,C12orf54,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0474293,0.0197959,0.00232737
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000177673,TEX44,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000177673,TEX44,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000177673,TEX44,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000177684,DEFB114,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000177684,DEFB114,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000177684,DEFB114,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000177689,MAGEB10,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 88.8889% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 96.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 92.3077% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000177689,MAGEB10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,-0.0269231,-0.01,-0.101111
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 88.8889% (minimum 99%, Missing); cerebral cortex: 96.0000% (minimum 99%, Missing); lymph node: 96.0000% (minimum 97%, Missing); retina: 96.0000% (minimum 99%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); skin: 92.3077% (minimum 95%, Missing); stomach: 96.0000% (minimum 97%, Missing)",0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000177689,MAGEB10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,-0.0269231,-0.01,-0.101111
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,2.8,1.9,2.4,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000177692,DNAJC28,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.8919% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.5556% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.0698% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.4045% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.4444% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.3404% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 71.5789% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.3117% (minimum 99%, Baseline (adaptation disabled)); colon: 86.0759% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.7746% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.0759% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.8333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.4045% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.2727% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.1183% (minimum 99%, Baseline (adaptation disabled)); liver: 73.1183% (minimum 99%, Baseline (adaptation disabled)); lung: 91.8919% (minimum 99%, Baseline (adaptation disabled)); midbrain: 78.1609% (minimum 99%, Baseline (adaptation disabled)); pancreas: 83.9506% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.9506% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.9268% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.8919% (minimum 97%, Baseline (adaptation disabled)); retina: 80.9524% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.9268% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.5789% (minimum 99%, Baseline (adaptation disabled)); skin: 91.8919% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.0759% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.7746% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.9524% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.0759% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.9277% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 73.9130% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.1609% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 91.8919% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,2.8,1.9,2.4,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000177692,DNAJC28,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.21087,-0.188391,-0.281667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.8919% (minimum 95%, Missing); adrenal gland: 75.5556% (minimum 99%, Missing); amygdala: 79.0698% (minimum 99%, Missing); basal ganglia: 76.4045% (minimum 99%, Missing); bone marrow: 94.4444% (minimum 99%, Missing); cerebellum: 72.3404% (minimum 99%, Missing); cerebral cortex: 71.5789% (minimum 99%, Missing); choroid plexus: 88.3117% (minimum 99%, Missing); colon: 86.0759% (minimum 97%, Missing); duodenum: 95.7746% (minimum 99%, Missing); esophagus: 86.0759% (minimum 97%, Missing); heart muscle: 70.8333% (minimum 99%, Missing); hippocampal formation: 76.4045% (minimum 99%, Missing); hypothalamus: 77.2727% (minimum 99%, Missing); kidney: 73.1183% (minimum 99%, Missing); liver: 73.1183% (minimum 99%, Missing); lung: 91.8919% (minimum 99%, Missing); midbrain: 78.1609% (minimum 99%, Missing); pancreas: 83.9506% (minimum 99%, Missing); parathyroid gland: 83.9506% (minimum 97%, Missing); pituitary gland: 82.9268% (minimum 99%, Missing); rectum: 91.8919% (minimum 97%, Missing); retina: 80.9524% (minimum 99%, Missing); salivary gland: 82.9268% (minimum 97%, Missing); skeletal muscle: 71.5789% (minimum 99%, Missing); skin: 91.8919% (minimum 95%, Missing); small intestine: 86.0759% (minimum 99%, Missing); smooth muscle: 95.7746% (minimum 99%, Missing); spinal cord: 80.9524% (minimum 99%, Missing); spleen: 86.0759% (minimum 95%, Missing); stomach: 81.9277% (minimum 97%, Missing); thyroid gland: 73.9130% (minimum 95%, Missing); tongue: 78.1609% (minimum 97%, Missing); urinary bladder: 91.8919% (minimum 97%, Missing)",0,0,routine_complete,2.8,1.9,2.4,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000177692,DNAJC28,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.21087,-0.188391,-0.281667
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,3.4,9.9,2.3,"parathyroid gland: 9.9 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 2); kidney: 3.2 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 2); heart muscle: 2.5 nTPM (vital, limit 2); rectum: 2.3 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000177694,NAALADL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.6190% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.9155% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.8462% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.8462% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.8254% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.8254% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.9155% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.8254% (minimum 99%, Baseline (adaptation disabled)); colon: 67.7778% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.2208% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.2632% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.9302% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.8462% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.3125% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.5914% (minimum 99%, Baseline (adaptation disabled)); liver: 68.5393% (minimum 99%, Baseline (adaptation disabled)); lung: 76.2500% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.4242% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.8462% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.3902% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 38.1250% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.4242% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.6190% (minimum 97%, Baseline (adaptation disabled)); retina: 80.2632% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 52.1368% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.1429% (minimum 99%, Baseline (adaptation disabled)); skin: 89.7059% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.2208% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.2105% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.7059% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.2500% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.1149% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.7222% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 73.4940% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.2208% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.2449% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,3.4,9.9,2.3,"parathyroid gland: 9.9 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); heart muscle: 2.5 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000177694,NAALADL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.22381,-0.58875,-0.347895
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.6190% (minimum 95%, Missing); adrenal gland: 85.9155% (minimum 98%, Approved); amygdala: 93.8462% (minimum 99%, Missing); basal ganglia: 93.8462% (minimum 99%, Missing); bone marrow: 96.8254% (minimum 98%, Approved); cerebellum: 96.8254% (minimum 98%, Approved); cerebral cortex: 85.9155% (minimum 99%, Missing); choroid plexus: 96.8254% (minimum 99%, Missing); colon: 67.7778% (minimum 97%, Missing); duodenum: 79.2208% (minimum 98%, Approved); esophagus: 80.2632% (minimum 95%, Approved); heart muscle: 70.9302% (minimum 98%, Approved); hippocampal formation: 93.8462% (minimum 99%, Missing); hypothalamus: 95.3125% (minimum 99%, Missing); kidney: 65.5914% (minimum 99%, Missing); liver: 68.5393% (minimum 98%, Approved); lung: 76.2500% (minimum 99%, Missing); lymph node: 92.4242% (minimum 95%, Approved); midbrain: 93.8462% (minimum 99%, Missing); pancreas: 74.3902% (minimum 99%, Missing); parathyroid gland: 38.1250% (minimum 97%, Missing); pituitary gland: 92.4242% (minimum 99%, Missing); rectum: 72.6190% (minimum 97%, Missing); retina: 80.2632% (minimum 99%, Missing); salivary gland: 52.1368% (minimum 97%, Missing); skeletal muscle: 87.1429% (minimum 99%, Missing); skin: 89.7059% (minimum 95%, Missing); small intestine: 79.2208% (minimum 98%, Approved); smooth muscle: 64.2105% (minimum 98%, Approved); spinal cord: 89.7059% (minimum 99%, Missing); spleen: 76.2500% (minimum 90%, Approved); stomach: 70.1149% (minimum 95%, Approved); thymus: 84.7222% (minimum 95%, Missing); thyroid gland: 73.4940% (minimum 90%, Approved); tongue: 79.2208% (minimum 97%, Missing); urinary bladder: 62.2449% (minimum 97%, Missing)",0,8,partial,3.4,9.9,2.3,"parathyroid gland: 9.9 nTPM (protected, limit 2); salivary gland: 5.6 nTPM (protected, limit 2); urinary bladder: 3.7 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 2); kidney: 3.2 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 2); heart muscle: 2.5 nTPM (vital, limit 2); rectum: 2.3 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000177694,NAALADL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.22381,-0.58875,-0.337895
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,4.2,1.1,0.9,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000177839,PCDHB9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.8571% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.0769% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.5172% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.0769% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.5172% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 31.1475% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.6087% (minimum 99%, Baseline (adaptation disabled)); colon: 65.5172% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.3636% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.8571% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.0769% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.1667% (minimum 99%, Baseline (adaptation disabled)); liver: 90.4762% (minimum 99%, Baseline (adaptation disabled)); lung: 63.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.0769% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 44.1860% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.4762% (minimum 97%, Baseline (adaptation disabled)); retina: 61.2903% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.5172% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.6087% (minimum 99%, Baseline (adaptation disabled)); skin: 73.0769% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.6087% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.0769% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.3636% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.6087% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 76.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.8571% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 70.3704% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,4.2,1.1,0.9,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000177839,PCDHB9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.271429,-0.336667,-0.678525
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 67.8571% (minimum 95%, Missing); adrenal gland: 73.0769% (minimum 99%, Missing); amygdala: 65.5172% (minimum 99%, Missing); basal ganglia: 73.0769% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 65.5172% (minimum 99%, Missing); cerebral cortex: 31.1475% (minimum 99%, Missing); choroid plexus: 82.6087% (minimum 99%, Missing); colon: 65.5172% (minimum 97%, Missing); duodenum: 95.0000% (minimum 99%, Missing); esophagus: 86.3636% (minimum 97%, Missing); heart muscle: 63.3333% (minimum 99%, Missing); hippocampal formation: 67.8571% (minimum 99%, Missing); hypothalamus: 73.0769% (minimum 99%, Missing); kidney: 79.1667% (minimum 99%, Missing); liver: 90.4762% (minimum 99%, Missing); lung: 63.3333% (minimum 99%, Missing); lymph node: 95.0000% (minimum 97%, Missing); midbrain: 76.0000% (minimum 99%, Missing); pancreas: 73.0769% (minimum 99%, Missing); parathyroid gland: 63.3333% (minimum 97%, Missing); pituitary gland: 44.1860% (minimum 99%, Missing); rectum: 90.4762% (minimum 97%, Missing); retina: 61.2903% (minimum 99%, Missing); salivary gland: 65.5172% (minimum 97%, Missing); skeletal muscle: 82.6087% (minimum 99%, Missing); skin: 73.0769% (minimum 95%, Missing); small intestine: 82.6087% (minimum 99%, Missing); smooth muscle: 63.3333% (minimum 99%, Missing); spinal cord: 73.0769% (minimum 99%, Missing); spleen: 86.3636% (minimum 95%, Missing); stomach: 82.6087% (minimum 97%, Missing); thyroid gland: 76.0000% (minimum 95%, Missing); tongue: 67.8571% (minimum 97%, Missing); urinary bladder: 70.3704% (minimum 97%, Missing)",0,6,partial,4.2,1.1,0.9,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000177839,PCDHB9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.271429,-0.336667,-0.678525
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.1,2.6,3.3,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000177842,ZNF620,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.8571% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 55.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 61.1111% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 57.8947% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 41.5094% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 40.7407% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.8889% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 61.1111% (minimum 99%, Baseline (adaptation disabled)); colon: 55.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.8947% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.7500% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.8947% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.1111% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 59.4595% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.8889% (minimum 99%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 99%, Baseline (adaptation disabled)); lung: 51.1628% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.7059% (minimum 97%, Baseline (adaptation disabled)); midbrain: 57.8947% (minimum 99%, Baseline (adaptation disabled)); pancreas: 47.8261% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 45.8333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 47.8261% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.1628% (minimum 97%, Baseline (adaptation disabled)); retina: 34.9206% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.7500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 46.8085% (minimum 99%, Baseline (adaptation disabled)); skin: 75.8621% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.4595% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.4595% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.4595% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.4103% (minimum 95%, Baseline (adaptation disabled)); stomach: 45.8333% (minimum 97%, Baseline (adaptation disabled)); thymus: 59.4595% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 40.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.8571% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.1,2.6,3.3,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000177842,ZNF620,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.55,-0.511667,-0.640794
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.8571% (minimum 95%, Missing); adrenal gland: 55.0000% (minimum 99%, Missing); amygdala: 61.1111% (minimum 99%, Missing); basal ganglia: 57.8947% (minimum 99%, Missing); bone marrow: 41.5094% (minimum 99%, Missing); cerebellum: 40.7407% (minimum 99%, Missing); cerebral cortex: 48.8889% (minimum 99%, Missing); choroid plexus: 61.1111% (minimum 99%, Missing); colon: 55.0000% (minimum 97%, Missing); duodenum: 57.8947% (minimum 99%, Missing); esophagus: 68.7500% (minimum 97%, Missing); heart muscle: 57.8947% (minimum 99%, Missing); hippocampal formation: 61.1111% (minimum 99%, Missing); hypothalamus: 59.4595% (minimum 99%, Missing); kidney: 48.8889% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Missing); lung: 51.1628% (minimum 99%, Missing); lymph node: 64.7059% (minimum 97%, Missing); midbrain: 57.8947% (minimum 99%, Missing); pancreas: 47.8261% (minimum 99%, Missing); parathyroid gland: 45.8333% (minimum 97%, Missing); pituitary gland: 47.8261% (minimum 99%, Missing); rectum: 51.1628% (minimum 97%, Missing); retina: 34.9206% (minimum 99%, Missing); salivary gland: 68.7500% (minimum 97%, Missing); skeletal muscle: 46.8085% (minimum 99%, Missing); skin: 75.8621% (minimum 95%, Missing); small intestine: 59.4595% (minimum 99%, Missing); smooth muscle: 59.4595% (minimum 99%, Missing); spinal cord: 59.4595% (minimum 99%, Missing); spleen: 56.4103% (minimum 95%, Missing); stomach: 45.8333% (minimum 97%, Missing); thymus: 59.4595% (minimum 95%, Missing); thyroid gland: 40.0000% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 62.8571% (minimum 97%, Missing)",0,80,unavailable,4.1,2.6,3.3,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000177842,ZNF620,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.55,-0.511667,-0.640794
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,4,3,2.9,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); liver: 2.3 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000177873,ZNF619,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.6364% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.2927% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 48.2759% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.1163% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.8696% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 71.7949% (minimum 99%, Baseline (adaptation disabled)); colon: 58.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 54.9020% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.2222% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 71.7949% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 99%, Baseline (adaptation disabled)); liver: 54.9020% (minimum 99%, Baseline (adaptation disabled)); lung: 59.5745% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.9020% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.2927% (minimum 99%, Baseline (adaptation disabled)); pancreas: 53.8462% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 48.2759% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.7949% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.8302% (minimum 97%, Baseline (adaptation disabled)); retina: 41.1765% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.8519% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 52.8302% (minimum 99%, Baseline (adaptation disabled)); skin: 54.9020% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.5745% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.6364% (minimum 99%, Baseline (adaptation disabled)); spleen: 49.1228% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.9020% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.1163% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 49.1228% (minimum 95%, Baseline (adaptation disabled)); tongue: 57.1429% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.6364% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,4,3,2.9,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); liver: 2.3 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000177873,ZNF619,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.458772,-0.487241,-0.578235
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 95%, Missing); adrenal gland: 63.6364% (minimum 99%, Missing); amygdala: 70.0000% (minimum 99%, Missing); basal ganglia: 68.2927% (minimum 99%, Missing); bone marrow: 48.2759% (minimum 99%, Missing); cerebellum: 65.1163% (minimum 99%, Missing); cerebral cortex: 60.8696% (minimum 99%, Missing); choroid plexus: 71.7949% (minimum 99%, Missing); colon: 58.3333% (minimum 97%, Missing); duodenum: 54.9020% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 62.2222% (minimum 99%, Missing); hippocampal formation: 70.0000% (minimum 99%, Missing); hypothalamus: 71.7949% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); liver: 54.9020% (minimum 99%, Missing); lung: 59.5745% (minimum 99%, Missing); lymph node: 54.9020% (minimum 97%, Missing); midbrain: 68.2927% (minimum 99%, Missing); pancreas: 53.8462% (minimum 99%, Missing); parathyroid gland: 48.2759% (minimum 97%, Missing); pituitary gland: 71.7949% (minimum 99%, Missing); rectum: 52.8302% (minimum 97%, Missing); retina: 41.1765% (minimum 99%, Missing); salivary gland: 51.8519% (minimum 97%, Missing); skeletal muscle: 52.8302% (minimum 99%, Missing); skin: 54.9020% (minimum 95%, Missing); small intestine: 59.5745% (minimum 99%, Missing); smooth muscle: 56.0000% (minimum 99%, Missing); spinal cord: 63.6364% (minimum 99%, Missing); spleen: 49.1228% (minimum 95%, Missing); stomach: 54.9020% (minimum 97%, Missing); thymus: 65.1163% (minimum 95%, Missing); thyroid gland: 49.1228% (minimum 95%, Missing); tongue: 57.1429% (minimum 97%, Missing); urinary bladder: 63.6364% (minimum 97%, Missing)",0,4,partial,4,3,2.9,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); rectum: 2.5 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); liver: 2.3 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); kidney: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000177873,ZNF619,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.458772,-0.487241,-0.578235
False,unresolved,incomplete_routine_rna,True,True,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000177910,SPATA31C2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Loriot 2025;da Silva 2017,,,
False,unresolved,incomplete_routine_rna,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000177910,SPATA31C2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000177910,SPATA31C2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,1.2,1.2,2.1,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000177938,CAPZA3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,1.2,1.2,2.1,"liver: 1.2 nTPM (vital, limit 1)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000177938,CAPZA3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0383073,0.0232848,0.00328483
True,compatible,,True,True,True,,0,1,partial,1.2,1.2,2.1,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,ENSG00000177938,CAPZA3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,3,partial,0.4,0,0,,,52,not_established,not_triggered,,,ENSG00000177947,ODF3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 95.7895% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.4,0,0,,,52,not_established,not_triggered,,,ENSG00000177947,ODF3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,-0.0321053
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 95.7895% (minimum 99%, Missing)",0,3,partial,0.4,0,0,,,52,not_established,not_triggered,,,ENSG00000177947,ODF3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,-0.0321053
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000177992,SPATA31E1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000177992,SPATA31E1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000177992,SPATA31E1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.8,0.8,1.1,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000177994,CIMIP6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9940% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.6190% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2332% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2036% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.8302% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.8131% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2332% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.7952% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0080% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2036% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.7952% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.4257% (minimum 99%, Baseline (adaptation disabled)); retina: 97.8131% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7952% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.8,0.8,1.1,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000177994,CIMIP6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0281312,0.014,-0.0616981
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.9940% (minimum 99%, Missing); amygdala: 97.6190% (minimum 99%, Missing); basal ganglia: 97.2332% (minimum 99%, Missing); cerebral cortex: 98.2036% (minimum 99%, Missing); choroid plexus: 92.8302% (minimum 99%, Missing); hippocampal formation: 97.8131% (minimum 99%, Missing); hypothalamus: 97.2332% (minimum 99%, Missing); kidney: 98.7952% (minimum 99%, Missing); lung: 98.0080% (minimum 99%, Missing); midbrain: 98.2036% (minimum 99%, Missing); pancreas: 98.7952% (minimum 99%, Missing); pituitary gland: 97.4257% (minimum 99%, Missing); retina: 97.8131% (minimum 99%, Missing); spinal cord: 98.7952% (minimum 99%, Missing)",0,80,unavailable,3.8,0.8,1.1,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000177994,CIMIP6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0281312,0.014,-0.0616981
True,compatible,,True,True,False,,0,1,partial,0.1,0,0,,,55,not_established,not_triggered,,,ENSG00000178021,TSPYL6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,55,not_established,not_triggered,,,ENSG00000178021,TSPYL6,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.00521531
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,55,not_established,not_triggered,,,ENSG00000178021,TSPYL6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.00521531
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,175.9,103.1,16,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 6); tongue: 103.1 nTPM (protected, limit 2); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 6); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 12); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 6); midbrain: 16.6 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); spinal cord: 15.3 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 6); urinary bladder: 13.6 nTPM (protected, limit 12); colon: 9.6 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 6); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 6)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178053,MLF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.3046% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.5079% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.7983% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1031% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.0351% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.4161% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 74.0232% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.2938% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.9863% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.9392% (minimum 99%, Baseline (adaptation disabled)); lung: 95.6750% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.8427% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.6276% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.1280% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.6033% (minimum 99%, Baseline (adaptation disabled)); retina: 89.3950% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 68.5106% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9912% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.5683% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.1558% (minimum 99%, Baseline (adaptation disabled)); tongue: 78.7773% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.5683% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,175.9,103.1,16,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 1); tongue: 103.1 nTPM (protected, limit 2); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 1); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 2); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.6 nTPM (vital, limit 1); thyroid gland: 16 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); spinal cord: 15.3 nTPM (vital, limit 1); urinary bladder: 13.6 nTPM (protected, limit 2); smooth muscle: 13.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (manageable, limit 5); esophagus: 9.8 nTPM (protected, limit 2); colon: 9.6 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); skin: 6 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 2); salivary gland: 4.9 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); small intestine: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178053,MLF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00986958,-0.182227,-0.304894
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.5079% (minimum 99%, Missing); basal ganglia: 92.7983% (minimum 99%, Missing); cerebellum: 98.1031% (minimum 99%, Missing); choroid plexus: 80.4161% (minimum 99%, Missing); heart muscle: 74.0232% (minimum 95%, Enhanced); hippocampal formation: 95.2938% (minimum 99%, Missing); hypothalamus: 94.9863% (minimum 99%, Missing); kidney: 94.9392% (minimum 95%, Enhanced); midbrain: 95.8427% (minimum 99%, Missing); pituitary gland: 95.6033% (minimum 99%, Missing); retina: 89.3950% (minimum 99%, Missing); skeletal muscle: 68.5106% (minimum 99%, Missing); spinal cord: 96.1558% (minimum 99%, Missing); tongue: 78.7773% (minimum 97%, Missing)",0,7,partial,175.9,103.1,16,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 6); tongue: 103.1 nTPM (protected, limit 2); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 6); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 12); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 6); midbrain: 16.6 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); spinal cord: 15.3 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 6); urinary bladder: 13.6 nTPM (protected, limit 12); colon: 9.6 nTPM (protected, limit 2); pancreas: 9.3 nTPM (vital, limit 6); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 6)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178053,MLF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.044026,-0.182227,-0.304894
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.2,0.9,1.5,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178093,TSSK6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,1.2,0.9,1.5,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178093,TSSK6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0408759,0.0245055,0.00268739
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,1.2,0.9,1.5,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178093,TSSK6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0408759,0.0245055,0.00268739
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.3,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000178125,PPP1R42,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8889% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.8022% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.7391% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.8022% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.7391% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.6989% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.8022% (minimum 99%, Baseline (adaptation disabled)); lung: 95.6989% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.8889% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.7391% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.8022% (minimum 99%, Baseline (adaptation disabled)); retina: 93.6842% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8889% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.3,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000178125,PPP1R42,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0173913,-0.0026087,-0.1
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8889% (minimum 99%, Missing); amygdala: 97.8022% (minimum 99%, Missing); basal ganglia: 96.7391% (minimum 99%, Missing); cerebral cortex: 97.8022% (minimum 99%, Missing); choroid plexus: 89.0000% (minimum 99%, Missing); hippocampal formation: 96.7391% (minimum 99%, Missing); hypothalamus: 95.6989% (minimum 99%, Missing); kidney: 97.8022% (minimum 99%, Missing); lung: 95.6989% (minimum 99%, Missing); midbrain: 98.8889% (minimum 99%, Missing); parathyroid gland: 96.7391% (minimum 97%, Missing); pituitary gland: 97.8022% (minimum 99%, Missing); retina: 93.6842% (minimum 99%, Missing); spinal cord: 98.8889% (minimum 99%, Missing)",0,80,unavailable,1.1,0.3,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000178125,PPP1R42,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0173913,-0.0026087,-0.1
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,6.8,4.4,4.7,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); parathyroid gland: 4.4 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); hypothalamus: 3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); skeletal muscle: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); amygdala: 2.3 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000178177,LCORL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.5122% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.2903% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.2500% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.0270% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.2903% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.6374% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.6747% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.8235% (minimum 99%, Baseline (adaptation disabled)); colon: 64.7727% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.4425% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.3704% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 78.0822% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.3704% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.5172% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.3750% (minimum 99%, Baseline (adaptation disabled)); liver: 63.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 67.8571% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.9565% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.5122% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.0449% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 56.4356% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.0822% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.9565% (minimum 97%, Baseline (adaptation disabled)); retina: 47.1074% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.1519% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 67.8571% (minimum 99%, Baseline (adaptation disabled)); skin: 54.8077% (minimum 95%, Baseline (adaptation disabled)); small intestine: 45.6000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.6747% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.7727% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.4356% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.2903% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.0588% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.8571% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,6.8,4.4,4.7,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); parathyroid gland: 4.4 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); hypothalamus: 3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); skeletal muscle: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); amygdala: 2.3 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000178177,LCORL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.401923,-0.405644,-0.534
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.5122% (minimum 95%, Missing); adrenal gland: 61.2903% (minimum 99%, Missing); amygdala: 71.2500% (minimum 99%, Missing); basal ganglia: 77.0270% (minimum 99%, Missing); bone marrow: 61.2903% (minimum 99%, Missing); cerebellum: 62.6374% (minimum 99%, Missing); cerebral cortex: 68.6747% (minimum 99%, Missing); choroid plexus: 83.8235% (minimum 99%, Missing); colon: 64.7727% (minimum 97%, Missing); duodenum: 50.4425% (minimum 99%, Missing); esophagus: 70.3704% (minimum 97%, Missing); heart muscle: 78.0822% (minimum 99%, Missing); hippocampal formation: 70.3704% (minimum 99%, Missing); hypothalamus: 65.5172% (minimum 99%, Missing); kidney: 59.3750% (minimum 99%, Missing); liver: 63.3333% (minimum 99%, Missing); lung: 67.8571% (minimum 99%, Missing); lymph node: 61.9565% (minimum 97%, Uncertain); midbrain: 69.5122% (minimum 99%, Missing); pancreas: 64.0449% (minimum 99%, Missing); parathyroid gland: 56.4356% (minimum 97%, Uncertain); pituitary gland: 78.0822% (minimum 99%, Missing); rectum: 61.9565% (minimum 97%, Missing); retina: 47.1074% (minimum 99%, Missing); salivary gland: 72.1519% (minimum 97%, Missing); skeletal muscle: 67.8571% (minimum 99%, Missing); skin: 54.8077% (minimum 95%, Missing); small intestine: 45.6000% (minimum 99%, Missing); smooth muscle: 68.6747% (minimum 99%, Missing); spinal cord: 64.7727% (minimum 99%, Missing); spleen: 63.3333% (minimum 95%, Uncertain); stomach: 56.4356% (minimum 97%, Missing); thymus: 60.0000% (minimum 95%, Missing); thyroid gland: 61.2903% (minimum 95%, Missing); tongue: 67.0588% (minimum 97%, Missing); urinary bladder: 67.8571% (minimum 97%, Missing)",0,1,partial,6.8,4.4,4.7,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 2); parathyroid gland: 4.4 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); hypothalamus: 3 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); skeletal muscle: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); amygdala: 2.3 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000178177,LCORL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.401923,-0.405644,-0.534
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.6,2.9,3.1,"parathyroid gland: 2.9 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178229,ZNF543,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.0769% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.8511% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.5510% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 67.8571% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.3704% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 71.6981% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.4444% (minimum 99%, Baseline (adaptation disabled)); colon: 74.5098% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.3636% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 73.0769% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.8511% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.6087% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.6981% (minimum 99%, Baseline (adaptation disabled)); liver: 77.5510% (minimum 99%, Baseline (adaptation disabled)); lung: 70.3704% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.2951% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.6087% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.8571% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 56.7164% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.0909% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.1667% (minimum 97%, Baseline (adaptation disabled)); retina: 59.3750% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.3704% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.0909% (minimum 99%, Baseline (adaptation disabled)); skin: 62.2951% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.5510% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.8511% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.3175% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.3704% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.0725% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.3175% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.8571% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.6981% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.6,2.9,3.1,"parathyroid gland: 2.9 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178229,ZNF543,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.399275,-0.402836,-0.39625
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Missing); adrenal gland: 73.0769% (minimum 99%, Missing); amygdala: 80.8511% (minimum 99%, Missing); basal ganglia: 77.5510% (minimum 99%, Missing); bone marrow: 67.8571% (minimum 99%, Missing); cerebellum: 70.3704% (minimum 99%, Missing); cerebral cortex: 71.6981% (minimum 99%, Missing); choroid plexus: 84.4444% (minimum 99%, Missing); colon: 74.5098% (minimum 97%, Missing); duodenum: 86.3636% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 73.0769% (minimum 99%, Missing); hippocampal formation: 80.8511% (minimum 99%, Missing); hypothalamus: 82.6087% (minimum 99%, Missing); kidney: 71.6981% (minimum 99%, Missing); liver: 77.5510% (minimum 99%, Missing); lung: 70.3704% (minimum 99%, Missing); lymph node: 62.2951% (minimum 97%, Missing); midbrain: 82.6087% (minimum 99%, Missing); pancreas: 67.8571% (minimum 99%, Missing); parathyroid gland: 56.7164% (minimum 97%, Missing); pituitary gland: 69.0909% (minimum 99%, Missing); rectum: 79.1667% (minimum 97%, Missing); retina: 59.3750% (minimum 99%, Missing); salivary gland: 70.3704% (minimum 97%, Missing); skeletal muscle: 69.0909% (minimum 99%, Missing); skin: 62.2951% (minimum 95%, Missing); small intestine: 77.5510% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 80.8511% (minimum 99%, Missing); spleen: 60.3175% (minimum 95%, Missing); stomach: 70.3704% (minimum 97%, Missing); thymus: 55.0725% (minimum 95%, Missing); thyroid gland: 60.3175% (minimum 95%, Missing); tongue: 67.8571% (minimum 97%, Missing); urinary bladder: 71.6981% (minimum 97%, Missing)",0,80,unavailable,2.6,2.9,3.1,"parathyroid gland: 2.9 nTPM (protected, limit 2); retina: 2.6 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178229,ZNF543,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.399275,-0.402836,-0.39625
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.6,0.3,0.6,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000178257,PRM3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.0787% (minimum 99%, Baseline (adaptation disabled)); retina: 98.5177% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.6,0.3,0.6,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000178257,PRM3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0431034,0.0265398,-0.0192135
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.0787% (minimum 99%, Missing); retina: 98.5177% (minimum 99%, Missing)",0,80,unavailable,2.6,0.3,0.6,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000178257,PRM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0431034,0.0265398,-0.0192135
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000178279,TNP2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000178279,TNP2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000178279,TNP2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,3,partial,0,0.1,0,,,52,not_established,not_triggered,,,ENSG00000178287,SPAG11A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0.1,0,,,52,not_established,not_triggered,,,ENSG00000178287,SPAG11A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.0299784,0.01
True,compatible,,True,True,True,,0,3,partial,0,0.1,0,,,52,not_established,not_triggered,,,ENSG00000178287,SPAG11A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,15,10.5,7.3,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 2); liver: 8.4 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); rectum: 6.7 nTPM (protected, limit 2); esophagus: 5.4 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); colon: 5 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178295,GEN1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.1121% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.3786% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 37.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.1089% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.3786% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.1818% (minimum 99%, Baseline (adaptation disabled)); colon: 64.2857% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.3802% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.3571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.2353% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.3786% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.1121% (minimum 99%, Baseline (adaptation disabled)); liver: 51.7241% (minimum 99%, Baseline (adaptation disabled)); lung: 82.5688% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.1538% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.2353% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.3571% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.6303% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.3248% (minimum 97%, Baseline (adaptation disabled)); retina: 78.9474% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.1121% (minimum 99%, Baseline (adaptation disabled)); skin: 55.2147% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.1642% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.3786% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.2857% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.6303% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.9371% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 83.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.5385% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.7143% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,15,10.5,7.3,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 2); liver: 8.4 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); rectum: 6.7 nTPM (protected, limit 2); esophagus: 5.4 nTPM (protected, limit 2); salivary gland: 5.4 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); colon: 5 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178295,GEN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.397853,-0.508462,-0.615
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 84.1121% (minimum 99%, Missing); amygdala: 90.0000% (minimum 99%, Missing); basal ganglia: 87.3786% (minimum 99%, Missing); bone marrow: 37.5000% (minimum 99%, Missing); cerebellum: 89.1089% (minimum 99%, Missing); cerebral cortex: 87.3786% (minimum 99%, Missing); choroid plexus: 68.1818% (minimum 99%, Missing); colon: 64.2857% (minimum 97%, Missing); duodenum: 74.3802% (minimum 99%, Missing); esophagus: 62.5000% (minimum 97%, Missing); heart muscle: 80.3571% (minimum 99%, Missing); hippocampal formation: 88.2353% (minimum 99%, Missing); hypothalamus: 87.3786% (minimum 99%, Missing); kidney: 84.1121% (minimum 99%, Missing); liver: 51.7241% (minimum 99%, Missing); lung: 82.5688% (minimum 99%, Missing); lymph node: 46.1538% (minimum 97%, Missing); midbrain: 88.2353% (minimum 99%, Missing); pancreas: 80.3571% (minimum 99%, Missing); parathyroid gland: 90.0000% (minimum 97%, Missing); pituitary gland: 75.6303% (minimum 99%, Missing); rectum: 57.3248% (minimum 97%, Missing); retina: 78.9474% (minimum 99%, Missing); salivary gland: 62.5000% (minimum 80%, Enhanced); skeletal muscle: 84.1121% (minimum 99%, Missing); skin: 55.2147% (minimum 95%, Missing); small intestine: 67.1642% (minimum 99%, Missing); smooth muscle: 87.3786% (minimum 99%, Missing); spinal cord: 90.0000% (minimum 99%, Missing); spleen: 64.2857% (minimum 95%, Missing); stomach: 75.6303% (minimum 97%, Missing); thymus: 62.9371% (minimum 95%, Missing); thyroid gland: 83.3333% (minimum 95%, Missing); tongue: 86.5385% (minimum 97%, Missing); urinary bladder: 85.7143% (minimum 97%, Missing)",0,3,partial,15,10.5,7.3,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 2); liver: 8.4 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); rectum: 6.7 nTPM (protected, limit 2); esophagus: 5.4 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); colon: 5 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178295,GEN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.397853,-0.508462,-0.615
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4,0.3,2.3,"liver: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000178297,TMPRSS9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 83.7209% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.8049% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2973% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.8182% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.2973% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.2973% (minimum 99%, Baseline (adaptation disabled)); colon: 92.3077% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.2973% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.2973% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2973% (minimum 99%, Baseline (adaptation disabled)); liver: 47.3684% (minimum 99%, Baseline (adaptation disabled)); pancreas: 83.7209% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.2973% (minimum 99%, Baseline (adaptation disabled)); retina: 97.2973% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.7368% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.8049% (minimum 99%, Baseline (adaptation disabled)); skin: 87.8049% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.2973% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.0169% (minimum 95%, Baseline (adaptation disabled)); thymus: 94.7368% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,4,0.3,2.3,"liver: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000178297,TMPRSS9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.339831,-0.0469231,-0.516316
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 83.7209% (minimum 99%, Missing); amygdala: 87.8049% (minimum 99%, Missing); basal ganglia: 97.2973% (minimum 99%, Missing); bone marrow: 81.8182% (minimum 99%, Missing); cerebellum: 97.2973% (minimum 99%, Missing); cerebral cortex: 97.2973% (minimum 99%, Missing); colon: 92.3077% (minimum 97%, Missing); duodenum: 97.2973% (minimum 99%, Missing); hippocampal formation: 97.2973% (minimum 99%, Missing); hypothalamus: 97.2973% (minimum 99%, Missing); liver: 47.3684% (minimum 99%, Missing); pancreas: 83.7209% (minimum 99%, Missing); pituitary gland: 97.2973% (minimum 99%, Missing); retina: 97.2973% (minimum 99%, Missing); salivary gland: 94.7368% (minimum 97%, Missing); skeletal muscle: 87.8049% (minimum 99%, Missing); skin: 87.8049% (minimum 95%, Missing); small intestine: 97.2973% (minimum 99%, Missing); spleen: 61.0169% (minimum 95%, Missing); thymus: 94.7368% (minimum 95%, Missing)",0,80,unavailable,4,0.3,2.3,"liver: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000178297,TMPRSS9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.339831,-0.0469231,-0.516316
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,8.1,3.9,3.5,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178385,PLEKHM3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.7241% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 42.8571% (minimum 99%, Baseline (adaptation disabled)); amygdala: 54.5455% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 49.1803% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 41.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 38.9610% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 36.5854% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.0811% (minimum 99%, Baseline (adaptation disabled)); colon: 50.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.9231% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.7241% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 43.4783% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 49.1803% (minimum 99%, Baseline (adaptation disabled)); lung: 50.8475% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.1818% (minimum 97%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.6923% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 43.4783% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.1818% (minimum 97%, Baseline (adaptation disabled)); retina: 27.0270% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.8235% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 56.6038% (minimum 99%, Baseline (adaptation disabled)); skin: 54.5455% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 44.7761% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.6923% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.8235% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 46.1538% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.2245% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,8.1,3.9,3.5,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178385,PLEKHM3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.488462,-0.535217,-0.71973
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.7241% (minimum 95%, Missing); adrenal gland: 42.8571% (minimum 99%, Missing); amygdala: 54.5455% (minimum 99%, Missing); basal ganglia: 49.1803% (minimum 99%, Missing); bone marrow: 41.6667% (minimum 99%, Missing); cerebellum: 38.9610% (minimum 99%, Missing); cerebral cortex: 36.5854% (minimum 99%, Missing); choroid plexus: 81.0811% (minimum 99%, Missing); colon: 50.0000% (minimum 97%, Missing); duodenum: 76.9231% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 51.7241% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 43.4783% (minimum 99%, Missing); kidney: 62.5000% (minimum 99%, Missing); liver: 49.1803% (minimum 99%, Missing); lung: 50.8475% (minimum 99%, Missing); lymph node: 68.1818% (minimum 97%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 57.6923% (minimum 99%, Missing); parathyroid gland: 43.4783% (minimum 97%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); rectum: 68.1818% (minimum 97%, Missing); retina: 27.0270% (minimum 99%, Missing); salivary gland: 58.8235% (minimum 97%, Missing); skeletal muscle: 56.6038% (minimum 99%, Missing); skin: 54.5455% (minimum 95%, Missing); small intestine: 62.5000% (minimum 99%, Missing); smooth muscle: 62.5000% (minimum 99%, Missing); spinal cord: 44.7761% (minimum 99%, Missing); spleen: 62.5000% (minimum 95%, Missing); stomach: 57.6923% (minimum 97%, Missing); thymus: 58.8235% (minimum 95%, Missing); thyroid gland: 46.1538% (minimum 95%, Missing); tongue: 66.6667% (minimum 97%, Missing); urinary bladder: 61.2245% (minimum 97%, Missing)",0,1,partial,8.1,3.9,3.5,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178385,PLEKHM3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.488462,-0.535217,-0.71973
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,5.1,5.5,6.2,"thyroid gland: 6.2 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); cerebellum: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); stomach: 4.7 nTPM (protected, limit 2); heart muscle: 4.7 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 2); smooth muscle: 3.7 nTPM (vital, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 2); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000178386,ZNF223,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 67.0213% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.6364% (minimum 99%, Baseline (adaptation disabled)); amygdala: 70.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 63.6364% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.9036% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.2632% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.1176% (minimum 99%, Baseline (adaptation disabled)); colon: 59.4340% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.7647% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.4783% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.2727% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.0213% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.6364% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.3762% (minimum 99%, Baseline (adaptation disabled)); liver: 71.5909% (minimum 99%, Baseline (adaptation disabled)); lung: 62.3762% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.2857% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.2308% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.2727% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.1650% (minimum 99%, Baseline (adaptation disabled)); rectum: 53.3898% (minimum 97%, Baseline (adaptation disabled)); retina: 59.4340% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.2857% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 75.9036% (minimum 99%, Baseline (adaptation disabled)); skin: 56.7568% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.5909% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.7568% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.2727% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.4000% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.7692% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.3762% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,5.1,5.5,6.2,"thyroid gland: 6.2 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); cerebellum: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); stomach: 4.7 nTPM (protected, limit 2); heart muscle: 4.7 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000178386,ZNF223,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.446,-0.436102,-0.437368
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 67.0213% (minimum 95%, Missing); adrenal gland: 63.6364% (minimum 99%, Missing); amygdala: 70.0000% (minimum 99%, Missing); basal ganglia: 63.6364% (minimum 99%, Missing); bone marrow: 75.9036% (minimum 99%, Missing); cerebellum: 55.2632% (minimum 99%, Missing); cerebral cortex: 60.0000% (minimum 99%, Missing); choroid plexus: 74.1176% (minimum 99%, Missing); colon: 59.4340% (minimum 97%, Missing); duodenum: 61.7647% (minimum 99%, Missing); esophagus: 68.4783% (minimum 97%, Missing); heart muscle: 57.2727% (minimum 99%, Missing); hippocampal formation: 67.0213% (minimum 99%, Missing); hypothalamus: 63.6364% (minimum 99%, Missing); kidney: 62.3762% (minimum 99%, Missing); liver: 71.5909% (minimum 98%, Approved); lung: 62.3762% (minimum 98%, Approved); lymph node: 64.2857% (minimum 95%, Approved); midbrain: 70.0000% (minimum 99%, Missing); pancreas: 69.2308% (minimum 99%, Missing); parathyroid gland: 57.2727% (minimum 97%, Missing); pituitary gland: 61.1650% (minimum 99%, Missing); rectum: 53.3898% (minimum 97%, Missing); retina: 59.4340% (minimum 99%, Missing); salivary gland: 64.2857% (minimum 97%, Missing); skeletal muscle: 75.9036% (minimum 98%, Approved); skin: 56.7568% (minimum 90%, Approved); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 63.0000% (minimum 98%, Approved); spinal cord: 71.5909% (minimum 99%, Missing); spleen: 56.7568% (minimum 90%, Approved); stomach: 57.2727% (minimum 97%, Missing); thymus: 70.0000% (minimum 95%, Missing); thyroid gland: 50.4000% (minimum 95%, Missing); tongue: 80.7692% (minimum 97%, Missing); urinary bladder: 62.3762% (minimum 97%, Missing)",0,8,partial,5.1,5.5,6.2,"thyroid gland: 6.2 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); cerebellum: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); stomach: 4.7 nTPM (protected, limit 2); heart muscle: 4.7 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 2); smooth muscle: 3.7 nTPM (vital, limit 2); adrenal gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 2); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000178386,ZNF223,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.446,-0.436102,-0.437368
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000178395,CCDC185,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000178395,CCDC185,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000178395,CCDC185,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.1,0,0,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000178403,NEUROG2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 51.6129% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 43.2432% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 45.7143% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.1905% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 44.4444% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.1176% (minimum 99%, Baseline (adaptation disabled)); retina: 76.1905% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.1176% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.1,0,0,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000178403,NEUROG2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.557568
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 51.6129% (minimum 99%, Missing); basal ganglia: 43.2432% (minimum 99%, Missing); cerebellum: 45.7143% (minimum 99%, Missing); cerebral cortex: 76.1905% (minimum 99%, Missing); hippocampal formation: 44.4444% (minimum 99%, Missing); hypothalamus: 94.1176% (minimum 99%, Missing); retina: 76.1905% (minimum 99%, Missing); spinal cord: 94.1176% (minimum 99%, Missing)",0,80,unavailable,2.1,0,0,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000178403,NEUROG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.557568
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2,0.7,0.4,"bone marrow: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus,ENSG00000178404,CEP295NL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.2432% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.5265% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2,0.7,0.4,"bone marrow: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus,ENSG00000178404,CEP295NL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,0.0357143,0.00526502,-0.0575676
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.2432% (minimum 99%, Missing); duodenum: 97.5265% (minimum 99%, Missing)",0,80,unavailable,2,0.7,0.4,"bone marrow: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus,ENSG00000178404,CEP295NL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,0.0357143,0.00526502,-0.0575676
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,1.5,1.9,1,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178409,BEND3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.2308% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.2609% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.7143% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 58.0645% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.7143% (minimum 99%, Baseline (adaptation disabled)); colon: 56.2500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.2857% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.8182% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.8182% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.0690% (minimum 99%, Baseline (adaptation disabled)); liver: 72.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 69.2308% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.2308% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.7143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.5455% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.2308% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.5455% (minimum 97%, Baseline (adaptation disabled)); retina: 69.2308% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.2500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.2857% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.7143% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.2609% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.6486% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.2857% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 69.2308% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.0000% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,1.5,1.9,1,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178409,BEND3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.307143,-0.483514,-0.444545
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.2308% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); amygdala: 78.2609% (minimum 99%, Missing); basal ganglia: 85.7143% (minimum 99%, Missing); bone marrow: 66.6667% (minimum 99%, Missing); cerebellum: 58.0645% (minimum 99%, Missing); cerebral cortex: 66.6667% (minimum 99%, Missing); choroid plexus: 85.7143% (minimum 99%, Missing); colon: 56.2500% (minimum 97%, Missing); duodenum: 60.0000% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 64.2857% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 81.8182% (minimum 99%, Missing); kidney: 62.0690% (minimum 99%, Missing); liver: 72.0000% (minimum 99%, Missing); lung: 69.2308% (minimum 99%, Missing); lymph node: 69.2308% (minimum 97%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 54.5455% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); pituitary gland: 69.2308% (minimum 99%, Missing); rectum: 54.5455% (minimum 97%, Missing); retina: 69.2308% (minimum 99%, Missing); salivary gland: 56.2500% (minimum 97%, Missing); skeletal muscle: 60.0000% (minimum 99%, Uncertain); skin: 75.0000% (minimum 95%, Missing); small intestine: 64.2857% (minimum 99%, Missing); smooth muscle: 72.0000% (minimum 99%, Missing); spinal cord: 85.7143% (minimum 99%, Missing); spleen: 78.2609% (minimum 95%, Uncertain); stomach: 48.6486% (minimum 97%, Missing); thymus: 64.2857% (minimum 95%, Missing); thyroid gland: 69.2308% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 72.0000% (minimum 97%, Uncertain)",0,1,partial,1.5,1.9,1,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178409,BEND3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.307143,-0.483514,-0.444545
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.8,2.7,2.1,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178460,MCMDC2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.0635% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.5672% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.0635% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.9225% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.8854% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 87.2180% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.2180% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.4790% (minimum 99%, Baseline (adaptation disabled)); colon: 94.3089% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.2308% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.8788% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.8571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.5484% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.0635% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.0635% (minimum 99%, Baseline (adaptation disabled)); liver: 95.0820% (minimum 99%, Baseline (adaptation disabled)); lung: 94.3089% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.1189% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.8000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.2308% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.3386% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.8000% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.3089% (minimum 97%, Baseline (adaptation disabled)); retina: 72.9560% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.2308% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 84.6715% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.9225% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.0635% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.6250% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.8000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 89.2308% (minimum 95%, Baseline (adaptation disabled)); tongue: 89.2308% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.3089% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.8,2.7,2.1,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178460,MCMDC2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.103285,-0.158811,-0.323333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.0635% (minimum 95%, Missing); adrenal gland: 86.5672% (minimum 99%, Missing); amygdala: 92.0635% (minimum 99%, Missing); basal ganglia: 89.9225% (minimum 99%, Missing); bone marrow: 73.8854% (minimum 99%, Missing); cerebellum: 87.2180% (minimum 99%, Missing); cerebral cortex: 87.2180% (minimum 99%, Missing); choroid plexus: 97.4790% (minimum 99%, Missing); colon: 94.3089% (minimum 97%, Missing); duodenum: 89.2308% (minimum 99%, Missing); esophagus: 87.8788% (minimum 97%, Missing); heart muscle: 82.8571% (minimum 99%, Missing); hippocampal formation: 93.5484% (minimum 99%, Missing); hypothalamus: 92.0635% (minimum 99%, Missing); kidney: 92.0635% (minimum 99%, Missing); liver: 95.0820% (minimum 99%, Missing); lung: 94.3089% (minimum 99%, Missing); lymph node: 81.1189% (minimum 97%, Missing); midbrain: 92.8000% (minimum 99%, Missing); pancreas: 89.2308% (minimum 99%, Missing); parathyroid gland: 91.3386% (minimum 97%, Missing); pituitary gland: 92.8000% (minimum 99%, Missing); rectum: 94.3089% (minimum 97%, Missing); retina: 72.9560% (minimum 99%, Missing); salivary gland: 89.2308% (minimum 97%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 84.6715% (minimum 95%, Missing); small intestine: 89.9225% (minimum 99%, Missing); spinal cord: 92.0635% (minimum 99%, Missing); spleen: 90.6250% (minimum 95%, Missing); stomach: 92.8000% (minimum 97%, Missing); thyroid gland: 89.2308% (minimum 95%, Missing); tongue: 89.2308% (minimum 97%, Missing); urinary bladder: 94.3089% (minimum 97%, Missing)",0,80,unavailable,5.8,2.7,2.1,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178460,MCMDC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.103285,-0.158811,-0.323333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,8.9,4.4,4.3,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000178502,KLHL11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4561% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.6610% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.1569% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 51.3661% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.1858% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 59.4937% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.3846% (minimum 99%, Baseline (adaptation disabled)); colon: 83.1858% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.6847% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.6847% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.1858% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.0693% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.3846% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.9916% (minimum 99%, Baseline (adaptation disabled)); liver: 79.6610% (minimum 99%, Baseline (adaptation disabled)); lung: 81.0345% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.0492% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.4228% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.1159% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.0693% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.6847% (minimum 97%, Baseline (adaptation disabled)); retina: 58.0247% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 81.0345% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.6296% (minimum 99%, Baseline (adaptation disabled)); skin: 75.2000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.6847% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.6847% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.0693% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.6860% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.0345% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.6860% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.6131% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.9286% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.2385% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,8.9,4.4,4.3,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000178502,KLHL11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.263869,-0.288841,-0.476339
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4561% (minimum 95%, Uncertain); adrenal gland: 79.6610% (minimum 99%, Missing); amygdala: 94.0000% (minimum 99%, Missing); basal ganglia: 92.1569% (minimum 99%, Missing); bone marrow: 51.3661% (minimum 99%, Missing); cerebellum: 83.1858% (minimum 99%, Missing); cerebral cortex: 59.4937% (minimum 99%, Missing); choroid plexus: 90.3846% (minimum 99%, Missing); colon: 83.1858% (minimum 97%, Missing); duodenum: 84.6847% (minimum 99%, Missing); esophagus: 84.6847% (minimum 97%, Uncertain); heart muscle: 83.1858% (minimum 99%, Missing); hippocampal formation: 93.0693% (minimum 99%, Missing); hypothalamus: 90.3846% (minimum 99%, Missing); kidney: 78.9916% (minimum 99%, Missing); liver: 79.6610% (minimum 99%, Missing); lung: 81.0345% (minimum 99%, Uncertain); lymph node: 77.0492% (minimum 97%, Uncertain); midbrain: 94.0000% (minimum 99%, Missing); pancreas: 76.4228% (minimum 99%, Missing); parathyroid gland: 68.1159% (minimum 97%, Missing); pituitary gland: 93.0693% (minimum 99%, Missing); rectum: 84.6847% (minimum 97%, Missing); retina: 58.0247% (minimum 99%, Missing); salivary gland: 81.0345% (minimum 97%, Missing); skeletal muscle: 69.6296% (minimum 99%, Missing); skin: 75.2000% (minimum 95%, Missing); small intestine: 84.6847% (minimum 99%, Missing); smooth muscle: 84.6847% (minimum 99%, Uncertain); spinal cord: 93.0693% (minimum 99%, Missing); spleen: 77.6860% (minimum 95%, Missing); stomach: 81.0345% (minimum 97%, Missing); thymus: 77.6860% (minimum 95%, Missing); thyroid gland: 68.6131% (minimum 95%, Missing); tongue: 83.9286% (minimum 97%, Missing); urinary bladder: 86.2385% (minimum 97%, Missing)",0,0,routine_complete,8.9,4.4,4.3,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000178502,KLHL11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.263869,-0.288841,-0.476339
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,80.7,49.2,56.3,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); skin: 56.3 nTPM (manageable, limit 5); parathyroid gland: 49.2 nTPM (protected, limit 2); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 2); adipose tissue: 26.9 nTPM (manageable, limit 5); spleen: 25.3 nTPM (manageable, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (manageable, limit 5); esophagus: 22 nTPM (protected, limit 2); tongue: 19 nTPM (protected, limit 2); lung: 18.2 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 2); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); spinal cord: 11.8 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); colon: 11 nTPM (protected, limit 2); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 2); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178573,MAF,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.2298% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.4286% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.1282% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.0807% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.3614% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.7815% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.8008% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.0282% (minimum 99%, Baseline (adaptation disabled)); colon: 77.3196% (minimum 97%, Baseline (adaptation disabled)); duodenum: 35.4108% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.0252% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.0340% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.1486% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.8124% (minimum 99%, Baseline (adaptation disabled)); kidney: 44.6429% (minimum 99%, Baseline (adaptation disabled)); liver: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 67.3250% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.3914% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.1688% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.3645% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 43.2526% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.0282% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.2881% (minimum 97%, Baseline (adaptation disabled)); retina: 89.2857% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.5306% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 43.9625% (minimum 99%, Baseline (adaptation disabled)); skin: 39.9787% (minimum 95%, Baseline (adaptation disabled)); small intestine: 31.7259% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.5558% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.0649% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.7134% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.7012% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.3060% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.6043% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.3717% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.6813% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,80.7,49.2,56.3,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); skin: 56.3 nTPM (manageable, limit 5); parathyroid gland: 49.2 nTPM (protected, limit 2); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 2); adipose tissue: 26.9 nTPM (manageable, limit 5); spleen: 25.3 nTPM (manageable, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (manageable, limit 5); esophagus: 22 nTPM (protected, limit 2); tongue: 19 nTPM (protected, limit 2); lung: 18.2 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 2); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); spinal cord: 11.8 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); colon: 11 nTPM (protected, limit 2); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 2); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178573,MAF,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.550213,-0.537474,-0.672741
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.2298% (minimum 95%, Missing); adrenal gland: 71.4286% (minimum 99%, Missing); amygdala: 80.1282% (minimum 99%, Missing); basal ganglia: 84.0807% (minimum 99%, Missing); bone marrow: 90.3614% (minimum 99%, Missing); cerebellum: 78.7815% (minimum 99%, Missing); cerebral cortex: 77.8008% (minimum 99%, Missing); choroid plexus: 88.0282% (minimum 99%, Missing); colon: 77.3196% (minimum 97%, Missing); duodenum: 35.4108% (minimum 99%, Missing); esophagus: 63.0252% (minimum 97%, Missing); heart muscle: 85.0340% (minimum 99%, Missing); hippocampal formation: 83.1486% (minimum 99%, Missing); hypothalamus: 85.8124% (minimum 99%, Missing); kidney: 44.6429% (minimum 99%, Missing); liver: 60.0000% (minimum 99%, Missing); lung: 67.3250% (minimum 99%, Missing); lymph node: 55.3914% (minimum 97%, Missing); midbrain: 81.1688% (minimum 99%, Missing); pancreas: 92.3645% (minimum 99%, Missing); parathyroid gland: 43.2526% (minimum 97%, Missing); pituitary gland: 88.0282% (minimum 99%, Missing); rectum: 78.2881% (minimum 97%, Missing); retina: 89.2857% (minimum 99%, Missing); salivary gland: 76.5306% (minimum 97%, Missing); skeletal muscle: 43.9625% (minimum 99%, Missing); skin: 39.9787% (minimum 95%, Missing); small intestine: 31.7259% (minimum 99%, Missing); smooth muscle: 68.5558% (minimum 99%, Missing); spinal cord: 76.0649% (minimum 99%, Missing); spleen: 59.7134% (minimum 95%, Missing); stomach: 74.7012% (minimum 97%, Missing); thymus: 68.3060% (minimum 95%, Missing); thyroid gland: 62.6043% (minimum 95%, Missing); tongue: 66.3717% (minimum 97%, Missing); urinary bladder: 68.6813% (minimum 97%, Missing)",0,0,routine_complete,80.7,49.2,56.3,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); skin: 56.3 nTPM (manageable, limit 5); parathyroid gland: 49.2 nTPM (protected, limit 2); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 2); adipose tissue: 26.9 nTPM (manageable, limit 5); spleen: 25.3 nTPM (manageable, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (manageable, limit 5); esophagus: 22 nTPM (protected, limit 2); tongue: 19 nTPM (protected, limit 2); lung: 18.2 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 2); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 2); spinal cord: 11.8 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 2); colon: 11 nTPM (protected, limit 2); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 2); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000178573,MAF,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.550213,-0.537474,-0.672741
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000178591,DEFB125,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000178591,DEFB125,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000178591,DEFB125,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0.3,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000178645,C10orf53,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.3,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000178645,C10orf53,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.042268,0.03,0.00226804
True,compatible,,True,True,True,,0,1,partial,0.3,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000178645,C10orf53,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00226804
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.7,1.4,1.4,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178665,ZNF713,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.8182% (minimum 99%, Baseline (adaptation disabled)); amygdala: 69.2308% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.5882% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 69.2308% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.0169% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 85.7143% (minimum 97%, Baseline (adaptation disabled)); duodenum: 78.2609% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.8049% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.7209% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 69.2308% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.5882% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.2609% (minimum 99%, Baseline (adaptation disabled)); liver: 85.7143% (minimum 99%, Baseline (adaptation disabled)); lung: 83.7209% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.7143% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.2308% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.7143% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.9245% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.8049% (minimum 97%, Baseline (adaptation disabled)); retina: 61.0169% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 67.9245% (minimum 99%, Baseline (adaptation disabled)); skin: 76.5957% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.2609% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.1429% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 73.4694% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.7209% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.7,1.4,1.4,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178665,ZNF713,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.23,-0.25,-0.418571
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.7143% (minimum 95%, Missing); adrenal gland: 81.8182% (minimum 99%, Missing); amygdala: 69.2308% (minimum 99%, Missing); basal ganglia: 70.5882% (minimum 99%, Missing); bone marrow: 69.2308% (minimum 99%, Missing); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 61.0169% (minimum 99%, Missing); choroid plexus: 80.0000% (minimum 99%, Missing); colon: 85.7143% (minimum 97%, Missing); duodenum: 78.2609% (minimum 99%, Missing); esophagus: 87.8049% (minimum 97%, Missing); heart muscle: 83.7209% (minimum 99%, Missing); hippocampal formation: 69.2308% (minimum 99%, Missing); hypothalamus: 70.5882% (minimum 99%, Missing); kidney: 78.2609% (minimum 99%, Missing); liver: 85.7143% (minimum 99%, Missing); lung: 83.7209% (minimum 99%, Missing); lymph node: 85.7143% (minimum 97%, Missing); midbrain: 69.2308% (minimum 99%, Missing); pancreas: 75.0000% (minimum 99%, Missing); parathyroid gland: 85.7143% (minimum 97%, Missing); pituitary gland: 67.9245% (minimum 99%, Missing); rectum: 87.8049% (minimum 97%, Missing); retina: 61.0169% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 67.9245% (minimum 99%, Missing); skin: 76.5957% (minimum 95%, Missing); small intestine: 85.7143% (minimum 99%, Missing); smooth muscle: 78.2609% (minimum 99%, Missing); spinal cord: 57.1429% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 72.0000% (minimum 97%, Missing); thymus: 72.0000% (minimum 95%, Missing); thyroid gland: 73.4694% (minimum 95%, Missing); tongue: 83.7209% (minimum 97%, Missing); urinary bladder: 90.0000% (minimum 97%, Missing)",0,80,unavailable,2.7,1.4,1.4,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178665,ZNF713,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.23,-0.25,-0.418571
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.6,3.8,3.4,"rectum: 3.8 nTPM (protected, limit 2); bone marrow: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178694,NSUN3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.1429% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.2373% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.7451% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 53.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 47.0588% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.3774% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.7273% (minimum 99%, Baseline (adaptation disabled)); colon: 48.4848% (minimum 97%, Baseline (adaptation disabled)); duodenum: 51.6129% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.2593% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.1818% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 60.3774% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 59.2593% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.1818% (minimum 99%, Baseline (adaptation disabled)); liver: 51.6129% (minimum 99%, Baseline (adaptation disabled)); lung: 55.1724% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.7937% (minimum 97%, Baseline (adaptation disabled)); midbrain: 60.3774% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.6129% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.2593% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.2593% (minimum 99%, Baseline (adaptation disabled)); rectum: 45.7143% (minimum 97%, Baseline (adaptation disabled)); retina: 49.2308% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.1724% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 74.4186% (minimum 99%, Baseline (adaptation disabled)); skin: 50.7937% (minimum 95%, Baseline (adaptation disabled)); small intestine: 52.4590% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.1429% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 58.1818% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.4848% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.7937% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.4590% (minimum 95%, Baseline (adaptation disabled)); tongue: 71.1111% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.1404% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.6,3.8,3.4,"rectum: 3.8 nTPM (protected, limit 2); bone marrow: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178694,NSUN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.465152,-0.512857,-0.519412
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.1429% (minimum 95%, Missing); adrenal gland: 54.2373% (minimum 99%, Missing); amygdala: 62.7451% (minimum 99%, Missing); basal ganglia: 53.3333% (minimum 99%, Missing); bone marrow: 47.0588% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 60.3774% (minimum 99%, Missing); choroid plexus: 72.7273% (minimum 99%, Missing); colon: 48.4848% (minimum 97%, Missing); duodenum: 51.6129% (minimum 99%, Missing); esophagus: 59.2593% (minimum 97%, Missing); heart muscle: 58.1818% (minimum 99%, Missing); hippocampal formation: 60.3774% (minimum 99%, Missing); hypothalamus: 59.2593% (minimum 99%, Missing); kidney: 58.1818% (minimum 99%, Missing); liver: 51.6129% (minimum 99%, Missing); lung: 55.1724% (minimum 99%, Missing); lymph node: 50.7937% (minimum 97%, Missing); midbrain: 60.3774% (minimum 99%, Missing); pancreas: 51.6129% (minimum 99%, Missing); parathyroid gland: 59.2593% (minimum 97%, Missing); pituitary gland: 59.2593% (minimum 99%, Missing); rectum: 45.7143% (minimum 97%, Missing); retina: 49.2308% (minimum 99%, Missing); salivary gland: 55.1724% (minimum 97%, Missing); skeletal muscle: 74.4186% (minimum 99%, Missing); skin: 50.7937% (minimum 95%, Missing); small intestine: 52.4590% (minimum 99%, Missing); smooth muscle: 57.1429% (minimum 99%, Missing); spinal cord: 58.1818% (minimum 99%, Missing); spleen: 48.4848% (minimum 95%, Missing); stomach: 50.7937% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing); thyroid gland: 52.4590% (minimum 95%, Missing); tongue: 71.1111% (minimum 97%, Missing); urinary bladder: 56.1404% (minimum 97%, Missing)",0,80,unavailable,3.6,3.8,3.4,"rectum: 3.8 nTPM (protected, limit 2); bone marrow: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); retina: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); liver: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178694,NSUN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.465152,-0.512857,-0.519412
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.4,0,0.1,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000178795,GDPD4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.7368% (minimum 99%, Baseline (adaptation disabled)); liver: 85.7143% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.2973% (minimum 99%, Baseline (adaptation disabled)); retina: 72.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.4,0,0.1,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000178795,GDPD4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.022973,0.03,-0.27
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.7368% (minimum 99%, Missing); liver: 85.7143% (minimum 99%, Missing); pituitary gland: 97.2973% (minimum 99%, Missing); retina: 72.0000% (minimum 99%, Missing)",0,80,unavailable,1.4,0,0.1,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000178795,GDPD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.022973,0.03,-0.27
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,10,partial,33.8,1,0,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),82,not_established,not_triggered,,,ENSG00000178796,RIIAD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.1406% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.6949% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.6745% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3372% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.6949% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.4610% (minimum 99%, Baseline (adaptation disabled)); colon: 96.0159% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.3673% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.5380% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.7516% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.1774% (minimum 99%, Baseline (adaptation disabled)); lung: 91.2879% (minimum 99%, Baseline (adaptation disabled)); midbrain: 87.9562% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7871% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 41.6235% (minimum 99%, Baseline (adaptation disabled)); retina: 83.6806% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.7705% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.4000% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.4000% (minimum 97%, Baseline (adaptation disabled))",0,10,partial,33.8,1,0,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),82,not_established,not_triggered,,,ENSG00000178796,RIIAD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,-0.00984064,-0.573765
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.1406% (minimum 95%, Enhanced); amygdala: 81.6949% (minimum 99%, Missing); basal ganglia: 70.6745% (minimum 99%, Missing); cerebellum: 92.3372% (minimum 95%, Enhanced); cerebral cortex: 81.6949% (minimum 95%, Enhanced); choroid plexus: 85.4610% (minimum 99%, Missing); colon: 96.0159% (minimum 97%, Missing); hippocampal formation: 79.5380% (minimum 99%, Missing); hypothalamus: 76.7516% (minimum 99%, Missing); lung: 91.2879% (minimum 95%, Enhanced); midbrain: 87.9562% (minimum 99%, Missing); pituitary gland: 41.6235% (minimum 99%, Missing); retina: 83.6806% (minimum 99%, Missing); small intestine: 98.7705% (minimum 99%, Missing); spinal cord: 96.4000% (minimum 99%, Missing)",0,10,partial,33.8,1,0,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),82,not_established,not_triggered,,,ENSG00000178796,RIIAD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,-0.00984064,-0.573765
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,False,,0,3,partial,0,0,0,,cerebellum / cells in molecular layer: Low (Enhanced),52,not_established,not_triggered,,,ENSG00000178804,H1-8,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0,3,partial,0,0,0,,cerebellum / cells in molecular layer: Low (Enhanced),52,not_established,not_triggered,,,ENSG00000178804,H1-8,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0,3,partial,0,0,0,,cerebellum / cells in molecular layer: Low (Enhanced),52,not_established,not_triggered,,,ENSG00000178804,H1-8,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.2,4.3,13.6,"thyroid gland: 13.6 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); parathyroid gland: 2.8 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178852,EFCAB13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.4629% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.7892% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.5854% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.0588% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.8983% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.9577% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.1165% (minimum 99%, Baseline (adaptation disabled)); colon: 87.6106% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.1475% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.9577% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.1892% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.0588% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1165% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.2000% (minimum 99%, Baseline (adaptation disabled)); liver: 85.7143% (minimum 99%, Baseline (adaptation disabled)); lung: 86.8421% (minimum 99%, Baseline (adaptation disabled)); lymph node: 82.1577% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.1165% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.0930% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.6106% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.7892% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.0870% (minimum 97%, Baseline (adaptation disabled)); retina: 83.8983% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.5854% (minimum 99%, Baseline (adaptation disabled)); skin: 90.4110% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.1892% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.1923% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.1577% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.9785% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.0930% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.2814% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 88.7892% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.2,4.3,13.6,"thyroid gland: 13.6 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); parathyroid gland: 2.8 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178852,EFCAB13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.357186,-0.148423,-0.198
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.4629% (minimum 95%, Missing); adrenal gland: 88.7892% (minimum 99%, Missing); amygdala: 96.5854% (minimum 99%, Missing); basal ganglia: 97.0588% (minimum 99%, Missing); bone marrow: 83.8983% (minimum 99%, Missing); cerebellum: 92.9577% (minimum 99%, Missing); cerebral cortex: 96.1165% (minimum 99%, Missing); colon: 87.6106% (minimum 97%, Missing); duodenum: 81.1475% (minimum 99%, Missing); esophagus: 92.9577% (minimum 97%, Missing); heart muscle: 89.1892% (minimum 99%, Missing); hippocampal formation: 97.0588% (minimum 99%, Missing); hypothalamus: 96.1165% (minimum 99%, Missing); kidney: 79.2000% (minimum 99%, Missing); liver: 85.7143% (minimum 99%, Missing); lung: 86.8421% (minimum 99%, Missing); lymph node: 82.1577% (minimum 97%, Missing); midbrain: 96.1165% (minimum 99%, Missing); pancreas: 92.0930% (minimum 99%, Missing); parathyroid gland: 87.6106% (minimum 97%, Missing); pituitary gland: 88.7892% (minimum 99%, Missing); rectum: 86.0870% (minimum 97%, Missing); retina: 83.8983% (minimum 99%, Missing); salivary gland: 90.0000% (minimum 97%, Missing); skeletal muscle: 96.5854% (minimum 99%, Missing); skin: 90.4110% (minimum 95%, Missing); small intestine: 85.7143% (minimum 99%, Missing); smooth muscle: 89.1892% (minimum 99%, Missing); spinal cord: 95.1923% (minimum 99%, Missing); spleen: 82.1577% (minimum 95%, Missing); stomach: 84.9785% (minimum 97%, Missing); thymus: 92.0930% (minimum 95%, Missing); thyroid gland: 59.2814% (minimum 95%, Missing); urinary bladder: 88.7892% (minimum 97%, Missing)",0,80,unavailable,5.2,4.3,13.6,"thyroid gland: 13.6 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 2); lung: 3 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); parathyroid gland: 2.8 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000178852,EFCAB13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.357186,-0.148423,-0.198
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0,0,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000178928,TPRX1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0,0,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000178928,TPRX1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.49
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 99%, Missing)",0,80,unavailable,1.1,0,0,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000178928,TPRX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.49
True,compatible,,True,True,False,,0,80,unavailable,0.4,0,0.2,,,0,not_established,not_triggered,,,ENSG00000178997,EXD1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 98.6395% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.3154% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0,0.2,,,0,not_established,not_triggered,,,ENSG00000178997,EXD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0363946,0.03,-0.0168456
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 98.6395% (minimum 99%, Missing); spinal cord: 97.3154% (minimum 99%, Missing)",0,80,unavailable,0.4,0,0.2,,,0,not_established,not_triggered,,,ENSG00000178997,EXD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0363946,0.03,-0.0168456
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.7,4.5,0.3,"pituitary gland: 4.7 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; thymus,ENSG00000179008,C14orf39,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.3659% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.2222% (minimum 99%, Baseline (adaptation disabled)); colon: 96.3303% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.1308% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.5946% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.3303% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.0789% (minimum 99%, Baseline (adaptation disabled)); retina: 80.1527% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.3582% (minimum 99%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.7,4.5,0.3,"pituitary gland: 4.7 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; thymus,ENSG00000179008,C14orf39,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0222222,-0.27,-0.299211
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.3659% (minimum 99%, Missing); choroid plexus: 97.2222% (minimum 99%, Missing); colon: 96.3303% (minimum 97%, Missing); duodenum: 98.1308% (minimum 99%, Missing); hypothalamus: 94.5946% (minimum 99%, Missing); parathyroid gland: 96.3303% (minimum 97%, Missing); pituitary gland: 69.0789% (minimum 99%, Missing); retina: 80.1527% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 78.3582% (minimum 99%, Missing); tongue: 75.0000% (minimum 97%, Missing)",0,80,unavailable,4.7,4.5,0.3,"pituitary gland: 4.7 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 2); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; thymus,ENSG00000179008,C14orf39,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0222222,-0.27,-0.299211
True,compatible,,True,True,False,,0,80,unavailable,0.4,0.1,0,,,0,not_established,not_triggered,,,ENSG00000179046,TRIML2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.6977% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.1220% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.1,0,,,0,not_established,not_triggered,,,ENSG00000179046,TRIML2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025;da Silva 2017,0.05,0.005,-0.0830233
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.5000% (minimum 99%, Missing); basal ganglia: 90.6977% (minimum 99%, Missing); cerebral cortex: 95.1220% (minimum 99%, Missing); lung: 97.5000% (minimum 99%, Missing)",0,80,unavailable,0.4,0.1,0,,,0,not_established,not_triggered,,,ENSG00000179046,TRIML2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025;da Silva 2017,0.05,0.005,-0.0830233
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179055,OR13D1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179055,OR13D1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179055,OR13D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.7,0.4,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000179059,ZFP42,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 95.2381% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.2381% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.2381% (minimum 99%, Baseline (adaptation disabled)); colon: 95.2381% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.9091% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.2381% (minimum 97%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.3333% (minimum 97%, Baseline (adaptation disabled)); rectum: 95.2381% (minimum 97%, Baseline (adaptation disabled)); retina: 95.2381% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.2381% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 74.0741% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.2381% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.2381% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.4,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000179059,ZFP42,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,-0.15,-0.136667,-0.249259
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 95.2381% (minimum 99%, Missing); bone marrow: 80.0000% (minimum 99%, Missing); cerebral cortex: 95.2381% (minimum 99%, Missing); choroid plexus: 95.2381% (minimum 99%, Missing); colon: 95.2381% (minimum 97%, Missing); duodenum: 90.9091% (minimum 99%, Missing); esophagus: 95.2381% (minimum 97%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 83.3333% (minimum 97%, Missing); rectum: 95.2381% (minimum 97%, Missing); retina: 95.2381% (minimum 99%, Missing); salivary gland: 95.2381% (minimum 97%, Missing); skeletal muscle: 74.0741% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); smooth muscle: 95.2381% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 95.2381% (minimum 97%, Missing); urinary bladder: 95.2381% (minimum 97%, Missing)",0,80,unavailable,0.7,0.4,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000179059,ZFP42,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,-0.15,-0.136667,-0.249259
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,1.6,1.2,0.6,"retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000179071,CCDC89,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.9215% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.6047% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.4713% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.5831% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6047% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.6959% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.9215% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.1481% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.6959% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.4713% (minimum 99%, Baseline (adaptation disabled)); lung: 97.4713% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.1481% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.2477% (minimum 99%, Baseline (adaptation disabled)); retina: 96.3636% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8345% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.5831% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.3759% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,1.6,1.2,0.6,"retina: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000179071,CCDC89,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0360465,0.00247706,-0.0263636
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.9215% (minimum 99%, Missing); amygdala: 98.6047% (minimum 99%, Missing); basal ganglia: 97.4713% (minimum 99%, Missing); choroid plexus: 97.6959% (minimum 99%, Missing); hippocampal formation: 98.1481% (minimum 99%, Missing); hypothalamus: 97.6959% (minimum 99%, Missing); kidney: 97.4713% (minimum 99%, Missing); midbrain: 98.1481% (minimum 99%, Missing); pituitary gland: 97.2477% (minimum 99%, Missing); retina: 96.3636% (minimum 99%, Missing); smooth muscle: 96.5831% (minimum 99%, Missing); spinal cord: 98.3759% (minimum 99%, Missing)",0,5,partial,1.6,1.2,0.6,"retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000179071,CCDC89,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0406542,0.0137587,-0.0263636
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.7,0.1,0.2,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000179083,FAM133A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 86.2069% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.5294% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.4754% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.3196% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.7547% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.9367% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 89.2857% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.5306% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.9835% (minimum 99%, Baseline (adaptation disabled)); midbrain: 76.5306% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 78.1250% (minimum 99%, Baseline (adaptation disabled)); retina: 85.2273% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.4026% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.7576% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,4.7,0.1,0.2,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000179083,FAM133A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.024026,0.0168421,-0.375246
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 86.2069% (minimum 99%, Missing); amygdala: 73.5294% (minimum 99%, Missing); basal ganglia: 61.4754% (minimum 99%, Missing); cerebellum: 77.3196% (minimum 99%, Missing); cerebral cortex: 70.7547% (minimum 99%, Missing); choroid plexus: 94.9367% (minimum 99%, Missing); heart muscle: 89.2857% (minimum 99%, Missing); hippocampal formation: 76.5306% (minimum 99%, Missing); hypothalamus: 61.9835% (minimum 99%, Missing); midbrain: 76.5306% (minimum 99%, Missing); pituitary gland: 78.1250% (minimum 99%, Missing); retina: 85.2273% (minimum 99%, Missing); smooth muscle: 97.4026% (minimum 99%, Missing); spinal cord: 75.7576% (minimum 99%, Missing)",0,80,unavailable,4.7,0.1,0.2,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000179083,FAM133A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.024026,0.0168421,-0.375246
True,compatible,,True,True,False,,0,80,unavailable,0.4,0.8,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000179088,C12orf42,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 95.4286% (minimum 97%, Baseline (adaptation disabled)); small intestine: 97.6608% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.3503% (minimum 95%, Baseline (adaptation disabled)); thymus: 92.7778% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.8,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000179088,C12orf42,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,-0.0222222,-0.0157143,-0.0133918
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 95.4286% (minimum 97%, Missing); small intestine: 97.6608% (minimum 99%, Missing); spleen: 94.3503% (minimum 95%, Missing); thymus: 92.7778% (minimum 95%, Missing)",0,80,unavailable,0.4,0.8,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000179088,C12orf42,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,-0.0222222,-0.0157143,-0.0133918
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,5.5,0.4,1.2,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000179133,C10orf67,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.3607% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.2381% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.2381% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.5610% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.7742% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.5714% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.0000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.4882% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.2381% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.9221% (minimum 99%, Baseline (adaptation disabled)); liver: 96.7742% (minimum 99%, Baseline (adaptation disabled)); lung: 81.0811% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.7742% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.3607% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.7742% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.9091% (minimum 99%, Baseline (adaptation disabled)); retina: 93.7500% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.7742% (minimum 99%, Baseline (adaptation disabled)); skin: 90.9091% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.5610% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.5610% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,5.5,0.4,1.2,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000179133,C10orf67,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0409091,-0.00225806,-0.304286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2381% (minimum 99%, Missing); basal ganglia: 95.2381% (minimum 99%, Missing); bone marrow: 97.5610% (minimum 98%, Approved); cerebral cortex: 96.7742% (minimum 98%, Approved); choroid plexus: 68.5714% (minimum 99%, Missing); duodenum: 96.0000% (minimum 98%, Approved); heart muscle: 95.2381% (minimum 99%, Missing); hippocampal formation: 94.4882% (minimum 99%, Missing); hypothalamus: 95.2381% (minimum 99%, Missing); kidney: 77.9221% (minimum 99%, Missing); liver: 96.7742% (minimum 98%, Approved); lung: 81.0811% (minimum 98%, Approved); midbrain: 96.7742% (minimum 99%, Missing); pituitary gland: 90.9091% (minimum 99%, Missing); retina: 93.7500% (minimum 99%, Missing); skeletal muscle: 96.7742% (minimum 98%, Approved); small intestine: 97.5610% (minimum 98%, Approved); spinal cord: 97.5610% (minimum 99%, Missing)",0,6,partial,5.5,0.4,1.2,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000179133,C10orf67,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00909091,0.0177419,-0.304286
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,0,routine_complete,173.3,0.1,0,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000179142,CYP11B2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,0,routine_complete,173.3,0.1,0,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000179142,CYP11B2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,0,routine_complete,173.3,0.1,0,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000179142,CYP11B2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000179165,PXT1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 95.6522% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.6522% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.6522% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.6522% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.6522% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.6522% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.6522% (minimum 99%, Baseline (adaptation disabled)); lung: 95.6522% (minimum 99%, Baseline (adaptation disabled)); retina: 95.6522% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); tongue: 95.6522% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.1,0.1,,,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000179165,PXT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00652174,-0.0134783,-0.11
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 95.6522% (minimum 99%, Missing); basal ganglia: 95.6522% (minimum 99%, Missing); bone marrow: 95.6522% (minimum 99%, Missing); cerebellum: 88.0000% (minimum 99%, Missing); cerebral cortex: 95.6522% (minimum 99%, Missing); heart muscle: 95.6522% (minimum 99%, Missing); hippocampal formation: 95.6522% (minimum 99%, Missing); hypothalamus: 95.6522% (minimum 99%, Missing); lung: 95.6522% (minimum 99%, Missing); retina: 95.6522% (minimum 99%, Missing); skeletal muscle: 91.6667% (minimum 99%, Missing); tongue: 95.6522% (minimum 97%, Missing)",0,80,unavailable,0.3,0.1,0.1,,,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000179165,PXT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00652174,-0.0134783,-0.11
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.8,0.7,1.1,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000179168,GGN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.4227% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.7342% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.8056% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.1963% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.1132% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9429% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.6301% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.0954% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.8,0.7,1.1,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000179168,GGN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0383844,0.0225769,-0.0190456
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.4227% (minimum 99%, Missing); basal ganglia: 98.7342% (minimum 99%, Missing); cerebral cortex: 97.8056% (minimum 99%, Missing); duodenum: 97.1963% (minimum 99%, Missing); hippocampal formation: 98.1132% (minimum 99%, Missing); hypothalamus: 98.9429% (minimum 99%, Missing); pituitary gland: 98.6301% (minimum 99%, Missing); small intestine: 97.0954% (minimum 99%, Missing)",0,80,unavailable,2.8,0.7,1.1,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000179168,GGN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0383844,0.0225769,-0.0190456
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179172,HNRNPCL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179172,HNRNPCL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179172,HNRNPCL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0.1,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000179213,SIGLECL1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0.1,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000179213,SIGLECL1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.045,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0.1,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000179213,SIGLECL1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,12,partial,94.8,60.5,56,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 2); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 2); adipose tissue: 56 nTPM (manageable, limit 5); parathyroid gland: 51 nTPM (protected, limit 2); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (manageable, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 2); esophagus: 37.2 nTPM (protected, limit 2); kidney: 36.1 nTPM (vital, limit 1); thymus: 33.4 nTPM (manageable, limit 5); lymph node: 31.8 nTPM (protected, limit 2); lung: 31.7 nTPM (vital, limit 1); colon: 31.4 nTPM (protected, limit 2); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 2); stomach: 28.1 nTPM (protected, limit 2); duodenum: 26 nTPM (vital, limit 1); skin: 25.3 nTPM (manageable, limit 5); spleen: 24.6 nTPM (manageable, limit 5); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 2); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000179295,PTPN11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.9689% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 56.4854% (minimum 99%, Baseline (adaptation disabled)); amygdala: 35.4641% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 35.9043% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.4505% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.2034% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 37.6045% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.7795% (minimum 99%, Baseline (adaptation disabled)); colon: 56.3282% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.9023% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.1236% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 38.5347% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 36.2254% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 38.9423% (minimum 99%, Baseline (adaptation disabled)); kidney: 52.8721% (minimum 99%, Baseline (adaptation disabled)); liver: 46.9293% (minimum 99%, Baseline (adaptation disabled)); lung: 56.0942% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.0166% (minimum 97%, Baseline (adaptation disabled)); midbrain: 29.9335% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.1062% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 44.2623% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.0641% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.1897% (minimum 97%, Baseline (adaptation disabled)); retina: 46.9838% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.6965% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 35.8407% (minimum 99%, Baseline (adaptation disabled)); skin: 61.5502% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.4037% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 48.5612% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 29.9778% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.2120% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.0379% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.8038% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 47.4239% (minimum 95%, Baseline (adaptation disabled)); tongue: 40.0990% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.4612% (minimum 97%, Baseline (adaptation disabled))",0,12,partial,94.8,60.5,56,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 1); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 2); adipose tissue: 56 nTPM (manageable, limit 5); parathyroid gland: 51 nTPM (protected, limit 2); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (manageable, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 2); esophagus: 37.2 nTPM (protected, limit 2); kidney: 36.1 nTPM (vital, limit 1); thymus: 33.4 nTPM (manageable, limit 5); lymph node: 31.8 nTPM (protected, limit 2); lung: 31.7 nTPM (vital, limit 1); colon: 31.4 nTPM (protected, limit 2); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 2); stomach: 28.1 nTPM (protected, limit 2); duodenum: 26 nTPM (vital, limit 1); skin: 25.3 nTPM (manageable, limit 5); spleen: 24.6 nTPM (manageable, limit 5); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 2); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000179295,PTPN11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.530311,-0.56901,-0.690665
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.9689% (minimum 95%, Missing); adrenal gland: 56.4854% (minimum 99%, Missing); amygdala: 35.4641% (minimum 99%, Missing); basal ganglia: 35.9043% (minimum 99%, Missing); bone marrow: 49.4505% (minimum 99%, Missing); cerebellum: 57.2034% (minimum 99%, Missing); cerebral cortex: 37.6045% (minimum 99%, Missing); choroid plexus: 63.7795% (minimum 99%, Missing); colon: 56.3282% (minimum 97%, Missing); duodenum: 60.9023% (minimum 99%, Missing); esophagus: 52.1236% (minimum 97%, Missing); heart muscle: 38.5347% (minimum 99%, Missing); hippocampal formation: 36.2254% (minimum 99%, Missing); hypothalamus: 38.9423% (minimum 99%, Missing); kidney: 52.8721% (minimum 99%, Missing); liver: 46.9293% (minimum 99%, Missing); lung: 56.0942% (minimum 99%, Missing); lymph node: 56.0166% (minimum 97%, Missing); midbrain: 29.9335% (minimum 99%, Missing); pancreas: 58.1062% (minimum 99%, Missing); parathyroid gland: 44.2623% (minimum 97%, Missing); pituitary gland: 72.0641% (minimum 99%, Missing); rectum: 58.1897% (minimum 97%, Missing); retina: 46.9838% (minimum 99%, Missing); salivary gland: 64.6965% (minimum 97%, Missing); skeletal muscle: 35.8407% (minimum 98%, Approved); skin: 61.5502% (minimum 95%, Missing); small intestine: 62.4037% (minimum 99%, Missing); smooth muscle: 48.5612% (minimum 99%, Missing); spinal cord: 29.9778% (minimum 99%, Missing); spleen: 62.2120% (minimum 95%, Missing); stomach: 59.0379% (minimum 97%, Missing); thymus: 54.8038% (minimum 95%, Missing); thyroid gland: 47.4239% (minimum 95%, Missing); tongue: 40.0990% (minimum 97%, Missing); urinary bladder: 51.4612% (minimum 97%, Missing)",0,12,partial,94.8,60.5,56,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 2); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 2); adipose tissue: 56 nTPM (manageable, limit 5); parathyroid gland: 51 nTPM (protected, limit 2); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (manageable, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 2); esophagus: 37.2 nTPM (protected, limit 2); kidney: 36.1 nTPM (vital, limit 1); thymus: 33.4 nTPM (manageable, limit 5); lymph node: 31.8 nTPM (protected, limit 2); lung: 31.7 nTPM (vital, limit 1); colon: 31.4 nTPM (protected, limit 2); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 2); stomach: 28.1 nTPM (protected, limit 2); duodenum: 26 nTPM (vital, limit 1); skin: 25.3 nTPM (manageable, limit 5); spleen: 24.6 nTPM (manageable, limit 5); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 2); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000179295,PTPN11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.530311,-0.56901,-0.690665
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,9.7,4.7,4.6,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); stomach: 3.1 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000179299,NSUN7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.6746% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.3855% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.8084% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.3855% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.1595% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.2568% (minimum 99%, Baseline (adaptation disabled)); colon: 85.5615% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.3955% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.8876% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.3855% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.0233% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.0488% (minimum 99%, Baseline (adaptation disabled)); liver: 97.5610% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.3855% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.5652% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.0513% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.4317% (minimum 97%, Baseline (adaptation disabled)); retina: 95.8084% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.2947% (minimum 97%, Baseline (adaptation disabled)); skin: 91.4286% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.8889% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.5673% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.1595% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.0215% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.7696% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 77.6699% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.4855% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,9.7,4.7,4.6,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); stomach: 3.1 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000179299,NSUN7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.173301,-0.197053,-0.367432
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.6746% (minimum 99%, Missing); amygdala: 96.3855% (minimum 99%, Missing); basal ganglia: 95.8084% (minimum 99%, Missing); bone marrow: 96.3855% (minimum 99%, Missing); cerebral cortex: 98.1595% (minimum 99%, Missing); choroid plexus: 62.2568% (minimum 99%, Missing); colon: 85.5615% (minimum 97%, Missing); duodenum: 90.3955% (minimum 99%, Missing); esophagus: 89.8876% (minimum 97%, Missing); heart muscle: 88.8889% (minimum 99%, Missing); hippocampal formation: 96.3855% (minimum 99%, Missing); hypothalamus: 93.0233% (minimum 99%, Missing); kidney: 78.0488% (minimum 99%, Missing); liver: 97.5610% (minimum 99%, Uncertain); lung: 83.3333% (minimum 99%, Missing); midbrain: 96.3855% (minimum 99%, Missing); pancreas: 69.5652% (minimum 99%, Missing); parathyroid gland: 83.3333% (minimum 97%, Missing); pituitary gland: 82.0513% (minimum 99%, Missing); rectum: 87.4317% (minimum 97%, Missing); retina: 95.8084% (minimum 99%, Missing); salivary gland: 77.2947% (minimum 97%, Missing); skin: 91.4286% (minimum 95%, Missing); small intestine: 88.8889% (minimum 99%, Missing); smooth muscle: 93.5673% (minimum 99%, Missing); spinal cord: 98.1595% (minimum 99%, Missing); spleen: 86.0215% (minimum 95%, Uncertain); stomach: 83.7696% (minimum 97%, Missing); thyroid gland: 77.6699% (minimum 95%, Missing); urinary bladder: 92.4855% (minimum 97%, Missing)",0,7,partial,9.7,4.7,4.6,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); stomach: 3.1 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000179299,NSUN7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.173301,-0.197053,-0.367432
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.2,1.3,0.4,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000179363,TMEM31,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8909% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.4361% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5267% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.9853% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2553% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.9853% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.2,1.3,0.4,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000179363,TMEM31,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0462756,0.0179963,-0.0101465
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8909% (minimum 99%, Missing); basal ganglia: 98.4361% (minimum 99%, Missing); hippocampal formation: 98.5267% (minimum 99%, Missing); hypothalamus: 97.9853% (minimum 99%, Missing); midbrain: 98.2553% (minimum 99%, Missing); spinal cord: 97.9853% (minimum 99%, Missing)",0,80,unavailable,2.2,1.3,0.4,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000179363,TMEM31,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0462756,0.0179963,-0.0101465
True,compatible,,True,True,False,,0,80,unavailable,1,0.8,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000179397,CATSPERE,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.2093% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.6636% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2093% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.2093% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.7593% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.6636% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.6636% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6636% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2093% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.8716% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2093% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6636% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.2093% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1221% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.3134% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.4338% (minimum 99%, Baseline (adaptation disabled)); retina: 97.2093% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.6636% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5849% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.3134% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1,0.8,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000179397,CATSPERE,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0087156,-0.00686636,-0.0356621
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.2093% (minimum 99%, Missing); amygdala: 97.6636% (minimum 99%, Missing); basal ganglia: 97.2093% (minimum 99%, Missing); bone marrow: 97.2093% (minimum 99%, Missing); cerebellum: 96.7593% (minimum 99%, Missing); cerebral cortex: 97.6636% (minimum 99%, Missing); choroid plexus: 97.6636% (minimum 99%, Missing); hippocampal formation: 97.6636% (minimum 99%, Missing); hypothalamus: 97.2093% (minimum 99%, Missing); kidney: 95.8716% (minimum 99%, Missing); liver: 97.2093% (minimum 99%, Missing); lung: 97.6636% (minimum 99%, Missing); midbrain: 97.2093% (minimum 99%, Missing); pancreas: 98.1221% (minimum 99%, Missing); parathyroid gland: 96.3134% (minimum 97%, Missing); pituitary gland: 95.4338% (minimum 99%, Missing); retina: 97.2093% (minimum 99%, Missing); skeletal muscle: 97.6636% (minimum 99%, Missing); small intestine: 98.5849% (minimum 99%, Missing); spinal cord: 96.3134% (minimum 99%, Missing)",0,80,unavailable,1,0.8,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000179397,CATSPERE,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0087156,-0.00686636,-0.0356621
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179407,DNAJB8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179407,DNAJB8,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179407,DNAJB8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179412,HNRNPCL4,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179412,HNRNPCL4,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179412,HNRNPCL4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000179468,OR9A2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000179468,OR9A2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000179468,OR9A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000179580,RNF151,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000179580,RNF151,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,0.0494598,0.0294598,0.00945975
True,compatible,,True,True,True,,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000179580,RNF151,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,0.0494598,0.0294598,0.00945975
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,11,partial,21.6,8.7,4.4,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 2); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); spinal cord: 5.3 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 2); retina: 3.4 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); small intestine: 3.1 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000179598,PLD6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.7398% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.7358% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.1275% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.1504% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.8152% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.0496% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.7358% (minimum 99%, Baseline (adaptation disabled)); colon: 70.3072% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.7928% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.2127% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.4688% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.8657% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.4385% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.0342% (minimum 99%, Baseline (adaptation disabled)); liver: 78.3270% (minimum 99%, Baseline (adaptation disabled)); lung: 88.4120% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.6596% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.4436% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.1024% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.9272% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.2807% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.3767% (minimum 97%, Baseline (adaptation disabled)); retina: 85.8333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 86.9198% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.4688% (minimum 99%, Baseline (adaptation disabled)); skin: 82.7309% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.9198% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.9563% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.5367% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.0645% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.7309% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.2127% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.5546% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.0639% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.4008% (minimum 97%, Baseline (adaptation disabled))",0,11,partial,21.6,8.7,4.4,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 2); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); spinal cord: 5.3 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); small intestine: 3.1 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000179598,PLD6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.126,-0.266928,-0.501848
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.4000% (minimum 90%, Approved); adrenal gland: 83.7398% (minimum 98%, Approved); amygdala: 77.7358% (minimum 99%, Missing); basal ganglia: 69.1275% (minimum 99%, Missing); bone marrow: 91.1504% (minimum 98%, Approved); cerebellum: 48.8152% (minimum 99%, Missing); cerebral cortex: 73.0496% (minimum 99%, Missing); choroid plexus: 77.7358% (minimum 99%, Missing); colon: 70.3072% (minimum 97%, Missing); duodenum: 92.7928% (minimum 99%, Missing); esophagus: 93.2127% (minimum 97%, Missing); heart muscle: 80.4688% (minimum 99%, Missing); hippocampal formation: 76.8657% (minimum 99%, Missing); hypothalamus: 68.4385% (minimum 99%, Missing); kidney: 88.0342% (minimum 99%, Missing); liver: 78.3270% (minimum 99%, Missing); lung: 88.4120% (minimum 99%, Missing); lymph node: 87.6596% (minimum 97%, Missing); midbrain: 77.4436% (minimum 99%, Missing); pancreas: 81.1024% (minimum 99%, Missing); parathyroid gland: 78.9272% (minimum 97%, Missing); pituitary gland: 72.2807% (minimum 99%, Missing); rectum: 92.3767% (minimum 97%, Missing); retina: 85.8333% (minimum 99%, Missing); salivary gland: 86.9198% (minimum 97%, Missing); skeletal muscle: 80.4688% (minimum 99%, Missing); skin: 82.7309% (minimum 95%, Missing); small intestine: 86.9198% (minimum 99%, Missing); smooth muscle: 89.9563% (minimum 99%, Missing); spinal cord: 79.5367% (minimum 99%, Missing); spleen: 83.0645% (minimum 90%, Approved); stomach: 82.7309% (minimum 97%, Missing); thymus: 93.2127% (minimum 95%, Missing); thyroid gland: 86.5546% (minimum 95%, Missing); tongue: 94.0639% (minimum 97%, Missing); urinary bladder: 83.4008% (minimum 97%, Missing)",0,11,partial,21.6,8.7,4.4,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 2); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 2); spinal cord: 5.3 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); adrenal gland: 4 nTPM (vital, limit 2); retina: 3.4 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); small intestine: 3.1 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000179598,PLD6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.122691,-0.266928,-0.501848
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000179600,GPHB5,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"retina: 50.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000179600,GPHB5,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.49
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"retina: 50.0000% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000179600,GPHB5,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.49
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,21,1.9,0.7,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,ENSG00000179603,GRM8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.1667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 38.2353% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 5.8296% (minimum 99%, Baseline (adaptation disabled)); colon: 46.4286% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.2500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.4211% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 59.0909% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.4211% (minimum 99%, Baseline (adaptation disabled)); liver: 32.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 86.6667% (minimum 99%, Baseline (adaptation disabled)); midbrain: 68.4211% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.4706% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 86.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 40.6250% (minimum 97%, Baseline (adaptation disabled)); retina: 40.6250% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.6667% (minimum 99%, Baseline (adaptation disabled)); stomach: 81.2500% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 65.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 76.4706% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,21,1.9,0.7,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,ENSG00000179603,GRM8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.3,-0.56375,-0.931704
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 99%, Missing); amygdala: 72.2222% (minimum 99%, Missing); basal ganglia: 54.1667% (minimum 99%, Missing); cerebellum: 86.6667% (minimum 99%, Missing); cerebral cortex: 38.2353% (minimum 99%, Missing); choroid plexus: 5.8296% (minimum 99%, Missing); colon: 46.4286% (minimum 97%, Missing); heart muscle: 81.2500% (minimum 99%, Missing); hippocampal formation: 68.4211% (minimum 99%, Missing); hypothalamus: 59.0909% (minimum 99%, Missing); kidney: 68.4211% (minimum 99%, Missing); liver: 32.5000% (minimum 99%, Missing); lung: 86.6667% (minimum 99%, Missing); midbrain: 68.4211% (minimum 99%, Missing); pancreas: 76.4706% (minimum 99%, Missing); pituitary gland: 86.6667% (minimum 99%, Missing); rectum: 40.6250% (minimum 97%, Missing); retina: 40.6250% (minimum 99%, Missing); smooth muscle: 92.8571% (minimum 99%, Missing); spinal cord: 86.6667% (minimum 99%, Missing); stomach: 81.2500% (minimum 97%, Missing); thyroid gland: 65.0000% (minimum 95%, Missing); urinary bladder: 76.4706% (minimum 97%, Missing)",0,80,unavailable,21,1.9,0.7,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,ENSG00000179603,GRM8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.3,-0.56375,-0.931704
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,12.8,4.5,0.1,"liver: 12.8 nTPM (vital, limit 6); tongue: 4.5 nTPM (protected, limit 2); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000179636,TPPP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"liver: 95.0864% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.7640% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,12.8,4.5,0.1,"liver: 12.8 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); skeletal muscle: 3.1 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000179636,TPPP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0495964,0.012157,-0.0391363
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0,3,partial,12.8,4.5,0.1,"liver: 12.8 nTPM (vital, limit 6); tongue: 4.5 nTPM (protected, limit 2); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000179636,TPPP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.012157,0.000863724
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179695,OR6C2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179695,OR6C2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179695,OR6C2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000179709,NLRP8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000179709,NLRP8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.303333,0.01
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"salivary gland: 66.6667% (minimum 97%, Missing)",0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000179709,NLRP8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.303333,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,27446.4,3.9,4.4,"pancreas: 27446.4 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000179751,SYCN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 86.1635% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.1631% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5612% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.9170% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.8198% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.4789% (minimum 99%, Baseline (adaptation disabled)); colon: 96.8198% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.8205% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.8097% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.4353% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5612% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9170% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.4789% (minimum 99%, Baseline (adaptation disabled)); liver: 90.4290% (minimum 99%, Baseline (adaptation disabled)); lung: 98.2079% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2079% (minimum 99%, Baseline (adaptation disabled)); pancreas: 0.0997% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.8198% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.5399% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.1631% (minimum 99%, Baseline (adaptation disabled)); skin: 94.4828% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.1581% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9170% (minimum 99%, Baseline (adaptation disabled)); stomach: 92.5676% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,27446.4,3.9,4.4,"pancreas: 27446.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); small intestine: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000179751,SYCN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0883648,-0.0946006,-0.989003
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.5612% (minimum 99%, Missing); basal ganglia: 98.9170% (minimum 99%, Missing); duodenum: 87.8205% (minimum 95%, Enhanced); heart muscle: 86.4353% (minimum 95%, Enhanced); hippocampal formation: 98.5612% (minimum 99%, Missing); hypothalamus: 98.9170% (minimum 99%, Missing); liver: 90.4290% (minimum 95%, Enhanced); midbrain: 98.2079% (minimum 99%, Missing); pancreas: 0.0997% (minimum 99%, Missing); pituitary gland: 96.8198% (minimum 99%, Missing); small intestine: 94.1581% (minimum 95%, Enhanced); spinal cord: 98.9170% (minimum 99%, Missing)",0,4,partial,27446.4,3.9,4.4,"pancreas: 27446.4 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000179751,SYCN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.989003
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,24.5,4.6,0.7,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 2); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 4); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,ENSG00000179796,LRRC3B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.5915% (minimum 99%, Baseline (adaptation disabled)); amygdala: 22.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 22.5806% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 24.5614% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 22.5806% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.4198% (minimum 99%, Baseline (adaptation disabled)); colon: 93.3333% (minimum 97%, Baseline (adaptation disabled)); esophagus: 94.5946% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.8904% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 31.1111% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 37.8378% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.5915% (minimum 99%, Baseline (adaptation disabled)); midbrain: 34.8259% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 82.3529% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 87.5000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.5946% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 43.4783% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.2222% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.5946% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 60.3448% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.9091% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 60.3448% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,24.5,4.6,0.7,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 1); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 2); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,ENSG00000179796,LRRC3B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0409091,-0.366552,-0.767778
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 22.2222% (minimum 99%, Missing); basal ganglia: 22.5806% (minimum 99%, Missing); cerebellum: 24.5614% (minimum 98%, Approved); cerebral cortex: 22.5806% (minimum 99%, Missing); choroid plexus: 86.4198% (minimum 99%, Missing); colon: 93.3333% (minimum 95%, Approved); esophagus: 94.5946% (minimum 95%, Approved); heart muscle: 95.8904% (minimum 98%, Approved); hippocampal formation: 31.1111% (minimum 99%, Missing); hypothalamus: 37.8378% (minimum 99%, Missing); midbrain: 34.8259% (minimum 99%, Missing); pituitary gland: 82.3529% (minimum 99%, Missing); rectum: 93.3333% (minimum 95%, Approved); retina: 87.5000% (minimum 99%, Missing); salivary gland: 94.5946% (minimum 95%, Approved); skeletal muscle: 43.4783% (minimum 99%, Missing); small intestine: 97.2222% (minimum 98%, Approved); smooth muscle: 94.5946% (minimum 98%, Approved); spinal cord: 60.3448% (minimum 99%, Missing); stomach: 93.3333% (minimum 95%, Approved); thymus: 90.9091% (minimum 95%, Missing); urinary bladder: 60.3448% (minimum 95%, Approved)",0,1,partial,24.5,4.6,0.7,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 2); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 4); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,ENSG00000179796,LRRC3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0409091,-0.346552,-0.767778
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179817,MRGPRX4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179817,MRGPRX4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179817,MRGPRX4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,44.1,1.2,2.9,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000179869,ABCA13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 83.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 3.2895% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.7500% (minimum 99%, Baseline (adaptation disabled)); colon: 88.2353% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.2353% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.5556% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 93.7500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.7500% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 55.5556% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.7500% (minimum 97%, Baseline (adaptation disabled)); pancreas: 68.1818% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 78.9474% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.2174% (minimum 97%, Baseline (adaptation disabled)); skin: 62.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.7500% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); thymus: 75.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 34.0909% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.7500% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,44.1,1.2,2.9,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000179869,ABCA13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.609091,-0.414444,-0.957105
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 3.2895% (minimum 99%, Missing); choroid plexus: 93.7500% (minimum 99%, Missing); colon: 88.2353% (minimum 97%, Missing); duodenum: 88.2353% (minimum 99%, Missing); esophagus: 55.5556% (minimum 97%, Missing); hippocampal formation: 93.7500% (minimum 99%, Missing); hypothalamus: 93.7500% (minimum 99%, Missing); kidney: 62.5000% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 55.5556% (minimum 99%, Missing); lymph node: 93.7500% (minimum 97%, Missing); pancreas: 68.1818% (minimum 99%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 78.9474% (minimum 99%, Missing); salivary gland: 65.2174% (minimum 97%, Missing); skin: 62.5000% (minimum 95%, Missing); small intestine: 93.7500% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); thymus: 75.0000% (minimum 95%, Missing); thyroid gland: 34.0909% (minimum 95%, Missing); urinary bladder: 93.7500% (minimum 97%, Missing)",0,80,unavailable,44.1,1.2,2.9,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000179869,ABCA13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.609091,-0.414444,-0.957105
True,compatible,,True,True,False,,0,80,unavailable,1,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,ENSG00000179873,NLRP11,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"colon: 91.6667% (minimum 97%, Baseline (adaptation disabled)); kidney: 84.6154% (minimum 99%, Baseline (adaptation disabled)); liver: 52.3810% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.6154% (minimum 97%, Baseline (adaptation disabled)); pancreas: 91.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.6154% (minimum 97%, Baseline (adaptation disabled)); rectum: 91.6667% (minimum 97%, Baseline (adaptation disabled)); spleen: 91.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.6154% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,ENSG00000179873,NLRP11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,-0.0333333,-0.123846,-0.46619
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"colon: 91.6667% (minimum 97%, Missing); kidney: 84.6154% (minimum 99%, Missing); liver: 52.3810% (minimum 99%, Missing); lymph node: 84.6154% (minimum 97%, Missing); pancreas: 91.6667% (minimum 99%, Missing); parathyroid gland: 84.6154% (minimum 97%, Missing); rectum: 91.6667% (minimum 97%, Missing); spleen: 91.6667% (minimum 95%, Missing); stomach: 84.6154% (minimum 97%, Missing)",0,80,unavailable,1,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,ENSG00000179873,NLRP11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,-0.0333333,-0.123846,-0.46619
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179919,OR10A7,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179919,OR10A7,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000179919,OR10A7,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,6.1,1.9,2.3,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000179988,PSTK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 79.0698% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.7143% (minimum 99%, Baseline (adaptation disabled)); amygdala: 58.6207% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.6207% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 35.7895% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.3404% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.1250% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.3404% (minimum 99%, Baseline (adaptation disabled)); colon: 69.3878% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.3846% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.3878% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.7377% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 54.8387% (minimum 99%, Baseline (adaptation disabled)); kidney: 64.1509% (minimum 99%, Baseline (adaptation disabled)); liver: 45.9459% (minimum 99%, Baseline (adaptation disabled)); lung: 77.2727% (minimum 99%, Baseline (adaptation disabled)); lymph node: 79.0698% (minimum 97%, Baseline (adaptation disabled)); midbrain: 58.6207% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.9630% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.2727% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.8333% (minimum 97%, Baseline (adaptation disabled)); retina: 87.1795% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.1509% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.7463% (minimum 99%, Baseline (adaptation disabled)); skin: 68.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.2727% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.3846% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 51.5152% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.5556% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.3404% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.6491% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.0698% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.3404% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,6.1,1.9,2.3,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000179988,PSTK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.353509,-0.328491,-0.632105
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 79.0698% (minimum 95%, Missing); adrenal gland: 60.7143% (minimum 99%, Missing); amygdala: 58.6207% (minimum 99%, Missing); basal ganglia: 58.6207% (minimum 99%, Missing); bone marrow: 35.7895% (minimum 99%, Missing); cerebellum: 72.3404% (minimum 99%, Missing); cerebral cortex: 53.1250% (minimum 99%, Missing); choroid plexus: 72.3404% (minimum 99%, Missing); colon: 69.3878% (minimum 97%, Missing); duodenum: 65.3846% (minimum 99%, Missing); esophagus: 69.3878% (minimum 97%, Missing); heart muscle: 68.0000% (minimum 99%, Missing); hippocampal formation: 55.7377% (minimum 99%, Missing); hypothalamus: 54.8387% (minimum 99%, Missing); kidney: 64.1509% (minimum 99%, Missing); liver: 45.9459% (minimum 99%, Missing); lung: 77.2727% (minimum 99%, Missing); lymph node: 79.0698% (minimum 97%, Missing); midbrain: 58.6207% (minimum 99%, Missing); pancreas: 62.9630% (minimum 99%, Missing); parathyroid gland: 77.2727% (minimum 97%, Missing); pituitary gland: 56.6667% (minimum 99%, Missing); rectum: 70.8333% (minimum 97%, Missing); retina: 87.1795% (minimum 99%, Missing); salivary gland: 64.1509% (minimum 97%, Missing); skeletal muscle: 50.7463% (minimum 99%, Missing); skin: 68.0000% (minimum 95%, Missing); small intestine: 77.2727% (minimum 99%, Missing); smooth muscle: 65.3846% (minimum 99%, Missing); spinal cord: 51.5152% (minimum 99%, Missing); spleen: 75.5556% (minimum 95%, Missing); stomach: 72.3404% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 59.6491% (minimum 95%, Missing); tongue: 79.0698% (minimum 97%, Missing); urinary bladder: 72.3404% (minimum 97%, Missing)",0,4,partial,6.1,1.9,2.3,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000179988,PSTK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.353509,-0.328491,-0.632105
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,ENSG00000180016,OR1E1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"skeletal muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,ENSG00000180016,OR1E1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.303333,-0.323333
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"skeletal muscle: 66.6667% (minimum 99%, Missing); tongue: 66.6667% (minimum 97%, Missing)",0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,ENSG00000180016,OR1E1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.303333,-0.323333
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000180043,GARIN5B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000180043,GARIN5B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00640288
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000180043,GARIN5B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00640288
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,0.6,1.5,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180083,WFDC11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.9345% (minimum 99%, Baseline (adaptation disabled)); retina: 97.9701% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.9,0.6,1.5,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180083,WFDC11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.0339056,0.0234995,-0.0206554
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.9345% (minimum 99%, Missing); retina: 97.9701% (minimum 99%, Missing)",0,80,unavailable,2.9,0.6,1.5,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180083,WFDC11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.0339056,0.0234995,-0.0206554
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000180090,OR3A1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"choroid plexus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 87.5000% (minimum 99%, Baseline (adaptation disabled)); thymus: 87.5000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000180090,OR3A1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.075,0.03,-0.115
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"choroid plexus: 87.5000% (minimum 99%, Missing); retina: 87.5000% (minimum 99%, Missing); thymus: 87.5000% (minimum 95%, Missing)",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000180090,OR3A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.075,0.03,-0.115
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,10.6,3.9,5.5,"cerebellum: 10.6 nTPM (vital, limit 6); retina: 8.6 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180113,TDRD6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.8553% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.0912% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.6508% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.5661% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.1613% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.7692% (minimum 99%, Baseline (adaptation disabled)); colon: 96.7213% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.0066% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.8553% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.8553% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.1613% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.6508% (minimum 99%, Baseline (adaptation disabled)); liver: 92.1875% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6821% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.3234% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.2492% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.4052% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.0494% (minimum 99%, Baseline (adaptation disabled)); retina: 77.4278% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.7792% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.0599% (minimum 99%, Baseline (adaptation disabled)); skin: 89.6657% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.6821% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6622% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.5513% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.4765% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.2857% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.4052% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,10.6,3.9,5.5,"cerebellum: 10.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); lymph node: 3.9 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180113,TDRD6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.107143,-0.0867665,-0.254339
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.8553% (minimum 95%, Enhanced); amygdala: 96.0912% (minimum 99%, Missing); basal ganglia: 93.6508% (minimum 99%, Missing); cerebellum: 73.5661% (minimum 95%, Enhanced); choroid plexus: 90.7692% (minimum 99%, Missing); heart muscle: 94.8553% (minimum 95%, Enhanced); hippocampal formation: 94.8553% (minimum 99%, Missing); hypothalamus: 95.1613% (minimum 99%, Missing); kidney: 93.6508% (minimum 95%, Enhanced); liver: 92.1875% (minimum 95%, Enhanced); midbrain: 94.2492% (minimum 99%, Missing); pituitary gland: 91.0494% (minimum 99%, Missing); retina: 77.4278% (minimum 99%, Missing); skeletal muscle: 93.0599% (minimum 95%, Enhanced); spinal cord: 94.5513% (minimum 99%, Missing)",0,2,partial,10.6,3.9,5.5,"cerebellum: 10.6 nTPM (vital, limit 6); retina: 8.6 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180113,TDRD6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.05,0.0266216,-0.215722
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000180116,REDIC1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000180116,REDIC1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0385057,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000180116,REDIC1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0385057,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000180138,CSNK1A1L,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 87.1795% (minimum 99%, Baseline (adaptation disabled)); lung: 97.1429% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000180138,CSNK1A1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0214286,0.03,-0.118205
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 87.1795% (minimum 99%, Missing); lung: 97.1429% (minimum 99%, Missing)",0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000180138,CSNK1A1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0214286,0.03,-0.118205
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,17,partial,71.2,26.8,16.3,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 6); tongue: 26.8 nTPM (protected, limit 2); colon: 22.5 nTPM (protected, limit 2); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 2); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 2); skin: 16.3 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 2); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 2); hypothalamus: 12.9 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 2); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); smooth muscle: 9.7 nTPM (vital, limit 6); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); thyroid gland: 8.7 nTPM (manageable, limit 5); spleen: 8.4 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / endothelial cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000180185,FAHD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.3776% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 38.3871% (minimum 99%, Baseline (adaptation disabled)); amygdala: 50.8547% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.1321% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 53.6036% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 58.6207% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 44.5693% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 53.3632% (minimum 99%, Baseline (adaptation disabled)); colon: 34.5930% (minimum 97%, Baseline (adaptation disabled)); duodenum: 23.1969% (minimum 99%, Baseline (adaptation disabled)); esophagus: 39.9329% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 37.7778% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 49.7908% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 47.9839% (minimum 99%, Baseline (adaptation disabled)); kidney: 14.3201% (minimum 99%, Baseline (adaptation disabled)); liver: 16.0377% (minimum 99%, Baseline (adaptation disabled)); lung: 60.7143% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 51.2931% (minimum 99%, Baseline (adaptation disabled)); pancreas: 43.1159% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 46.8504% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.9378% (minimum 99%, Baseline (adaptation disabled)); rectum: 42.3488% (minimum 97%, Baseline (adaptation disabled)); retina: 61.9792% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 54.0909% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 28.9538% (minimum 99%, Baseline (adaptation disabled)); skin: 42.1986% (minimum 95%, Baseline (adaptation disabled)); small intestine: 28.5372% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.0926% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 52.6549% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.6207% (minimum 95%, Baseline (adaptation disabled)); stomach: 38.1410% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.4879% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.7670% (minimum 95%, Baseline (adaptation disabled)); tongue: 30.7494% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.1250% (minimum 97%, Baseline (adaptation disabled))",0,17,partial,71.2,26.8,16.3,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 26.8 nTPM (protected, limit 2); colon: 22.5 nTPM (protected, limit 2); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 2); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 2); skin: 16.3 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 2); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 2); hypothalamus: 12.9 nTPM (vital, limit 1); adipose tissue: 12.2 nTPM (manageable, limit 5); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 2); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); thyroid gland: 8.7 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 2); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / endothelial cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000180185,FAHD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.528014,-0.662506,-0.846799
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.3776% (minimum 60%, Enhanced); adrenal gland: 38.3871% (minimum 99%, Missing); amygdala: 50.8547% (minimum 99%, Missing); basal ganglia: 56.1321% (minimum 99%, Missing); bone marrow: 53.6036% (minimum 99%, Missing); cerebellum: 58.6207% (minimum 99%, Missing); cerebral cortex: 44.5693% (minimum 99%, Missing); choroid plexus: 53.3632% (minimum 99%, Missing); colon: 34.5930% (minimum 97%, Missing); duodenum: 23.1969% (minimum 99%, Missing); esophagus: 39.9329% (minimum 97%, Missing); heart muscle: 37.7778% (minimum 99%, Missing); hippocampal formation: 49.7908% (minimum 99%, Missing); hypothalamus: 47.9839% (minimum 99%, Missing); kidney: 14.3201% (minimum 99%, Missing); liver: 16.0377% (minimum 99%, Missing); lung: 60.7143% (minimum 99%, Missing); lymph node: 59.5000% (minimum 80%, Enhanced); midbrain: 51.2931% (minimum 99%, Missing); pancreas: 43.1159% (minimum 99%, Missing); parathyroid gland: 46.8504% (minimum 97%, Missing); pituitary gland: 56.9378% (minimum 99%, Missing); rectum: 42.3488% (minimum 97%, Missing); retina: 61.9792% (minimum 99%, Missing); salivary gland: 54.0909% (minimum 97%, Missing); skeletal muscle: 28.9538% (minimum 95%, Enhanced); skin: 42.1986% (minimum 95%, Missing); small intestine: 28.5372% (minimum 99%, Missing); smooth muscle: 55.0926% (minimum 95%, Enhanced); spinal cord: 52.6549% (minimum 99%, Missing); spleen: 58.6207% (minimum 95%, Missing); stomach: 38.1410% (minimum 97%, Missing); thymus: 57.4879% (minimum 95%, Missing); thyroid gland: 57.7670% (minimum 95%, Missing); tongue: 30.7494% (minimum 97%, Missing); urinary bladder: 53.1250% (minimum 97%, Missing)",0,17,partial,71.2,26.8,16.3,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 6); tongue: 26.8 nTPM (protected, limit 2); colon: 22.5 nTPM (protected, limit 2); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 2); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 2); skin: 16.3 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 2); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 2); hypothalamus: 12.9 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 2); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 2); smooth muscle: 9.7 nTPM (vital, limit 6); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); thyroid gland: 8.7 nTPM (manageable, limit 5); spleen: 8.4 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / endothelial cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000180185,FAHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.528014,-0.662506,-0.846799
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000180205,WFDC9,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000180205,WFDC9,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000180205,WFDC9,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000180219,GARIN6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000180219,GARIN6,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.00695122
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000180219,GARIN6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.00695122
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000180269,GPR139,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"basal ganglia: 20.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 20.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 33.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000180269,GPR139,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.79
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"basal ganglia: 20.0000% (minimum 99%, Missing); bone marrow: 20.0000% (minimum 99%, Missing); choroid plexus: 50.0000% (minimum 99%, Missing); hypothalamus: 33.3333% (minimum 99%, Missing)",0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000180269,GPR139,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.79
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,ENSG00000180305,WFDC10A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,ENSG00000180305,WFDC10A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.0296436,0.00964362
True,compatible,,True,True,True,,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,ENSG00000180305,WFDC10A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.0296436,0.00964362
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,3.3,0.4,0.8,"retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180336,MEIOC,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2979% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.6744% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.5075% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.8553% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.6744% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.8814% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.5075% (minimum 99%, Baseline (adaptation disabled)); liver: 98.5075% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2979% (minimum 99%, Baseline (adaptation disabled)); retina: 96.8553% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.6522% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5075% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,3.3,0.4,0.8,"cerebellum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180336,MEIOC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,0.0329787,0.0214163,-0.0566667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2979% (minimum 99%, Missing); basal ganglia: 97.6744% (minimum 99%, Missing); cerebellum: 93.3333% (minimum 95%, Enhanced); hippocampal formation: 97.6744% (minimum 99%, Missing); hypothalamus: 97.8814% (minimum 99%, Missing); midbrain: 98.2979% (minimum 99%, Missing); retina: 96.8553% (minimum 99%, Missing); spinal cord: 98.5075% (minimum 99%, Missing)",0,1,partial,3.3,0.4,0.8,"retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180336,MEIOC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,-0.0214465
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,5.4,3.9,4.1,"bone marrow: 5.4 nTPM (vital, limit 2); stomach: 3.9 nTPM (protected, limit 2); lymph node: 3.3 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 2); small intestine: 2.7 nTPM (vital, limit 2); retina: 2.6 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 2); adrenal gland: 2.5 nTPM (vital, limit 2); midbrain: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 2); pancreas: 2.3 nTPM (vital, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180423,HARBI1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.4015% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.3944% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.3134% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.1727% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.4211% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.8571% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.6897% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.6364% (minimum 99%, Baseline (adaptation disabled)); colon: 80.1370% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.8182% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.1727% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.9787% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.7826% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.6897% (minimum 99%, Baseline (adaptation disabled)); liver: 79.0541% (minimum 99%, Baseline (adaptation disabled)); lung: 84.7826% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.9787% (minimum 99%, Baseline (adaptation disabled)); pancreas: 83.5714% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.7826% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.9787% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 81.8182% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 81.2500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.3944% (minimum 99%, Baseline (adaptation disabled)); skin: 79.0541% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.2500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.1370% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.6897% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.9787% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 74.0506% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.8182% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.0294% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.3944% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,5.4,3.9,4.1,"bone marrow: 5.4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); lymph node: 3.3 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); smooth muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); salivary gland: 2.7 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180423,HARBI1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.209494,-0.22,-0.305789
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.4015% (minimum 90%, Approved); adrenal gland: 82.3944% (minimum 98%, Approved); amygdala: 87.3134% (minimum 99%, Missing); basal ganglia: 84.1727% (minimum 99%, Missing); bone marrow: 68.4211% (minimum 98%, Approved); cerebellum: 92.8571% (minimum 98%, Approved); cerebral cortex: 80.6897% (minimum 98%, Approved); choroid plexus: 88.6364% (minimum 99%, Missing); colon: 80.1370% (minimum 95%, Approved); duodenum: 81.8182% (minimum 98%, Approved); esophagus: 84.1727% (minimum 95%, Approved); heart muscle: 82.9787% (minimum 98%, Approved); hippocampal formation: 84.7826% (minimum 99%, Missing); hypothalamus: 86.6667% (minimum 99%, Missing); kidney: 80.6897% (minimum 98%, Approved); liver: 79.0541% (minimum 98%, Approved); lung: 84.7826% (minimum 98%, Approved); lymph node: 78.0000% (minimum 97%, Missing); midbrain: 82.9787% (minimum 99%, Missing); pancreas: 83.5714% (minimum 98%, Approved); parathyroid gland: 84.7826% (minimum 95%, Approved); pituitary gland: 82.9787% (minimum 99%, Missing); rectum: 78.0000% (minimum 95%, Approved); retina: 81.8182% (minimum 99%, Missing); salivary gland: 81.2500% (minimum 95%, Approved); skeletal muscle: 82.3944% (minimum 98%, Approved); skin: 79.0541% (minimum 90%, Approved); small intestine: 81.2500% (minimum 98%, Approved); smooth muscle: 80.1370% (minimum 98%, Approved); spinal cord: 80.6897% (minimum 99%, Missing); spleen: 82.9787% (minimum 90%, Approved); stomach: 75.0000% (minimum 97%, Missing); thymus: 74.0506% (minimum 95%, Missing); thyroid gland: 81.8182% (minimum 90%, Approved); tongue: 86.0294% (minimum 97%, Missing); urinary bladder: 82.3944% (minimum 95%, Approved)",0,4,partial,5.4,3.9,4.1,"bone marrow: 5.4 nTPM (vital, limit 2); stomach: 3.9 nTPM (protected, limit 2); lymph node: 3.3 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 2); small intestine: 2.7 nTPM (vital, limit 2); retina: 2.6 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 2); adrenal gland: 2.5 nTPM (vital, limit 2); midbrain: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 2); pancreas: 2.3 nTPM (vital, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180423,HARBI1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.209494,-0.22,-0.295789
True,compatible,,True,True,False,,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000180424,DEFB123,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000180424,DEFB123,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0493553,0.03,0.007426
True,compatible,,True,True,True,,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000180424,DEFB123,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0493553,0.03,0.007426
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,21.6,14.6,12.1,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 2); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); salivary gland: 9.5 nTPM (protected, limit 2); spleen: 9.1 nTPM (manageable, limit 5); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); thymus: 8.7 nTPM (manageable, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 2); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); lymph node: 6.5 nTPM (protected, limit 2); rectum: 6 nTPM (protected, limit 2); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (manageable, limit 5); urinary bladder: 4.4 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180425,C11orf71,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.9161% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.0300% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.9152% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.3343% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.6078% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.1724% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.0070% (minimum 99%, Baseline (adaptation disabled)); colon: 95.2750% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.8070% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.9849% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.7543% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6554% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.3455% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.9764% (minimum 99%, Baseline (adaptation disabled)); liver: 86.2157% (minimum 99%, Baseline (adaptation disabled)); lung: 95.8836% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.4096% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.2814% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.0808% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.0153% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.1606% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.7477% (minimum 97%, Baseline (adaptation disabled)); retina: 89.7674% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.4302% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.3075% (minimum 99%, Baseline (adaptation disabled)); skin: 93.6893% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.8736% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.9695% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.3445% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.6893% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.0070% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.9499% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.7799% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.2472% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.8459% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,21.6,14.6,12.1,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 2); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); salivary gland: 9.5 nTPM (protected, limit 2); spleen: 9.1 nTPM (manageable, limit 5); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); thymus: 8.7 nTPM (manageable, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 2); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); lymph node: 6.5 nTPM (protected, limit 2); rectum: 6 nTPM (protected, limit 2); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (manageable, limit 5); urinary bladder: 4.4 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180425,C11orf71,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.0322011,-0.0675284,-0.127843
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.9161% (minimum 99%, Missing); amygdala: 92.0300% (minimum 99%, Missing); basal ganglia: 90.9152% (minimum 99%, Missing); bone marrow: 97.3343% (minimum 99%, Missing); cerebellum: 94.6078% (minimum 99%, Missing); cerebral cortex: 93.1724% (minimum 99%, Missing); choroid plexus: 95.0070% (minimum 99%, Missing); colon: 95.2750% (minimum 97%, Missing); duodenum: 94.8070% (minimum 99%, Missing); esophagus: 96.9849% (minimum 97%, Missing); heart muscle: 93.7543% (minimum 99%, Missing); hippocampal formation: 91.6554% (minimum 99%, Missing); hypothalamus: 91.3455% (minimum 99%, Missing); kidney: 90.9764% (minimum 99%, Missing); liver: 86.2157% (minimum 99%, Missing); lung: 95.8836% (minimum 99%, Missing); lymph node: 95.4096% (minimum 97%, Missing); midbrain: 92.2814% (minimum 99%, Missing); pancreas: 94.0808% (minimum 99%, Missing); parathyroid gland: 94.0153% (minimum 97%, Missing); pituitary gland: 91.1606% (minimum 99%, Missing); rectum: 95.7477% (minimum 97%, Missing); retina: 89.7674% (minimum 99%, Missing); salivary gland: 93.4302% (minimum 97%, Missing); skeletal muscle: 90.3075% (minimum 99%, Missing); skin: 93.6893% (minimum 95%, Missing); small intestine: 94.8736% (minimum 99%, Missing); smooth muscle: 97.9695% (minimum 99%, Missing); spinal cord: 92.3445% (minimum 99%, Missing); spleen: 93.6893% (minimum 95%, Missing); stomach: 95.0070% (minimum 97%, Missing); thymus: 93.9499% (minimum 95%, Missing); thyroid gland: 91.7799% (minimum 95%, Missing); tongue: 90.2472% (minimum 97%, Missing); urinary bladder: 96.8459% (minimum 97%, Missing)",0,80,unavailable,21.6,14.6,12.1,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 2); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); salivary gland: 9.5 nTPM (protected, limit 2); spleen: 9.1 nTPM (manageable, limit 5); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); thymus: 8.7 nTPM (manageable, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 2); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); lymph node: 6.5 nTPM (protected, limit 2); rectum: 6 nTPM (protected, limit 2); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (manageable, limit 5); urinary bladder: 4.4 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180425,C11orf71,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.0322011,-0.0675284,-0.127843
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,28,11.6,75.2,"thyroid gland: 75.2 nTPM (manageable, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 2); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); thymus: 6 nTPM (manageable, limit 5); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); spinal cord: 5.4 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180479,ZNF571,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.9006% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.8879% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.2162% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.7709% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 62.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.0570% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 71.9388% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 71.2121% (minimum 99%, Baseline (adaptation disabled)); colon: 81.0345% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.0370% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.9006% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.9006% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.2105% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.6032% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.5094% (minimum 99%, Baseline (adaptation disabled)); liver: 80.1136% (minimum 99%, Baseline (adaptation disabled)); lung: 78.7709% (minimum 99%, Baseline (adaptation disabled)); lymph node: 72.3077% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.2162% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.9767% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 54.8638% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.1145% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.5714% (minimum 97%, Baseline (adaptation disabled)); retina: 33.4917% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 81.5029% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.9006% (minimum 99%, Baseline (adaptation disabled)); skin: 62.9464% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.4320% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.4011% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.3077% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.6804% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.7709% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.1493% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 15.7895% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.2135% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.6304% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,28,11.6,75.2,"thyroid gland: 75.2 nTPM (manageable, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 2); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); thymus: 6 nTPM (manageable, limit 5); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); spinal cord: 5.4 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180479,ZNF571,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.792105,-0.421362,-0.655083
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.9006% (minimum 95%, Missing); adrenal gland: 65.8879% (minimum 99%, Missing); amygdala: 76.2162% (minimum 99%, Missing); basal ganglia: 78.7709% (minimum 99%, Missing); bone marrow: 62.6667% (minimum 99%, Missing); cerebellum: 73.0570% (minimum 99%, Missing); cerebral cortex: 71.9388% (minimum 99%, Missing); choroid plexus: 71.2121% (minimum 99%, Missing); colon: 81.0345% (minimum 97%, Missing); duodenum: 87.0370% (minimum 99%, Missing); esophagus: 77.9006% (minimum 97%, Missing); heart muscle: 77.9006% (minimum 99%, Missing); hippocampal formation: 74.2105% (minimum 99%, Missing); hypothalamus: 74.6032% (minimum 99%, Missing); kidney: 66.5094% (minimum 99%, Missing); liver: 80.1136% (minimum 99%, Missing); lung: 78.7709% (minimum 99%, Missing); lymph node: 72.3077% (minimum 97%, Missing); midbrain: 76.2162% (minimum 99%, Missing); pancreas: 81.9767% (minimum 99%, Missing); parathyroid gland: 54.8638% (minimum 97%, Missing); pituitary gland: 62.1145% (minimum 99%, Missing); rectum: 80.5714% (minimum 97%, Missing); retina: 33.4917% (minimum 99%, Missing); salivary gland: 81.5029% (minimum 97%, Missing); skeletal muscle: 77.9006% (minimum 99%, Missing); skin: 62.9464% (minimum 95%, Missing); small intestine: 83.4320% (minimum 99%, Missing); smooth muscle: 75.4011% (minimum 99%, Missing); spinal cord: 72.3077% (minimum 99%, Missing); spleen: 72.6804% (minimum 95%, Missing); stomach: 78.7709% (minimum 97%, Missing); thymus: 70.1493% (minimum 95%, Missing); thyroid gland: 15.7895% (minimum 95%, Missing); tongue: 79.2135% (minimum 97%, Missing); urinary bladder: 76.6304% (minimum 97%, Missing)",0,80,unavailable,28,11.6,75.2,"thyroid gland: 75.2 nTPM (manageable, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 2); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); thymus: 6 nTPM (manageable, limit 5); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); spinal cord: 5.4 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 2); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); basal ganglia: 3.8 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 2); liver: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180479,ZNF571,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.792105,-0.421362,-0.655083
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,6.4,3.9,2.3,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180481,GLIPR1L2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.7699% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.0732% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.0732% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.2103% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.4021% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.1783% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.6928% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.5696% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.4490% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.0185% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.9746% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2103% (minimum 99%, Baseline (adaptation disabled)); lung: 97.4194% (minimum 99%, Baseline (adaptation disabled)); midbrain: 89.5257% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.5720% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.0732% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.7699% (minimum 99%, Baseline (adaptation disabled)); retina: 94.3750% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.5696% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.4783% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.8402% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.6209% (minimum 99%, Baseline (adaptation disabled)); tongue: 96.7949% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,6.4,3.9,2.3,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180481,GLIPR1L2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00168067,-0.0492683,-0.113791
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 94.7699% (minimum 95%, Enhanced); amygdala: 92.0732% (minimum 99%, Missing); basal ganglia: 92.0732% (minimum 99%, Missing); cerebral cortex: 93.4021% (minimum 95%, Enhanced); choroid plexus: 96.1783% (minimum 99%, Missing); hippocampal formation: 92.4490% (minimum 99%, Missing); hypothalamus: 93.0185% (minimum 99%, Missing); kidney: 95.9746% (minimum 99%, Missing); midbrain: 89.5257% (minimum 99%, Missing); pancreas: 94.5720% (minimum 95%, Enhanced); pituitary gland: 94.7699% (minimum 99%, Missing); retina: 94.3750% (minimum 99%, Missing); spinal cord: 87.6209% (minimum 99%, Missing); tongue: 96.7949% (minimum 97%, Missing)",0,3,partial,6.4,3.9,2.3,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180481,GLIPR1L2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.022103,-0.00205128,-0.113791
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,150.8,0.1,0.1,"retina: 150.8 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000180483,DEFB119,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 92.5402% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,150.8,0.1,0.1,"retina: 150.8 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000180483,DEFB119,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0499465,0.0299465,-0.0645981
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 92.5402% (minimum 99%, Missing)",0,3,partial,150.8,0.1,0.1,"retina: 150.8 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000180483,DEFB119,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,-0.0645981
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,1,1.2,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180592,SKIDA1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 84.2105% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.1905% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.7273% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.7273% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.5385% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 72.7273% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.1176% (minimum 99%, Baseline (adaptation disabled)); esophagus: 88.8889% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.1429% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.7273% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.1905% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 99%, Baseline (adaptation disabled)); liver: 53.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 84.2105% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.1176% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.1905% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.5385% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.1905% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 51.6129% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.1905% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); skin: 61.5385% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.1176% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.2105% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.2105% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.1176% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.8889% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.8889% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.8889% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.2105% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.5,1,1.2,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180592,SKIDA1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.378571,-0.354615,-0.473871
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 84.2105% (minimum 95%, Missing); adrenal gland: 76.1905% (minimum 99%, Missing); amygdala: 72.7273% (minimum 99%, Missing); basal ganglia: 64.0000% (minimum 99%, Missing); bone marrow: 72.7273% (minimum 99%, Missing); cerebellum: 64.0000% (minimum 99%, Missing); cerebral cortex: 61.5385% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 72.7273% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); esophagus: 88.8889% (minimum 97%, Missing); heart muscle: 57.1429% (minimum 99%, Missing); hippocampal formation: 72.7273% (minimum 99%, Missing); hypothalamus: 76.1905% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); liver: 53.3333% (minimum 99%, Missing); lung: 84.2105% (minimum 99%, Missing); lymph node: 94.1176% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 76.1905% (minimum 99%, Missing); parathyroid gland: 61.5385% (minimum 97%, Missing); pituitary gland: 76.1905% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 51.6129% (minimum 99%, Missing); salivary gland: 76.1905% (minimum 97%, Missing); skeletal muscle: 94.1176% (minimum 99%, Missing); skin: 61.5385% (minimum 95%, Missing); small intestine: 94.1176% (minimum 99%, Missing); smooth muscle: 84.2105% (minimum 99%, Missing); spinal cord: 84.2105% (minimum 99%, Missing); spleen: 94.1176% (minimum 95%, Missing); stomach: 88.8889% (minimum 97%, Missing); thymus: 88.8889% (minimum 95%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); tongue: 88.8889% (minimum 97%, Missing); urinary bladder: 84.2105% (minimum 97%, Missing)",0,80,unavailable,1.5,1,1.2,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000180592,SKIDA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.378571,-0.354615,-0.473871
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,27.3,19.2,23.4,"heart muscle: 27.3 nTPM (vital, limit 2); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 10); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 2); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 4); thymus: 18.9 nTPM (manageable, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); spleen: 17.4 nTPM (manageable, limit 10); duodenum: 17.1 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 4); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 4); tongue: 16 nTPM (protected, limit 2); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 4); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 2); rectum: 13.7 nTPM (protected, limit 4); adipose tissue: 13.2 nTPM (manageable, limit 10); basal ganglia: 13.2 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 2); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 2); urinary bladder: 11.8 nTPM (protected, limit 2); smooth muscle: 11.5 nTPM (vital, limit 2); skin: 10.9 nTPM (manageable, limit 5); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 2); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000180628,PCGF5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6842% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 42.0330% (minimum 99%, Baseline (adaptation disabled)); amygdala: 50.3289% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 53.6842% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.8571% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.2000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 45.9459% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 50.8306% (minimum 97%, Baseline (adaptation disabled)); duodenum: 47.2222% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.2347% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 35.9155% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.8387% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 50.6623% (minimum 99%, Baseline (adaptation disabled)); kidney: 40.3694% (minimum 99%, Baseline (adaptation disabled)); liver: 37.5921% (minimum 99%, Baseline (adaptation disabled)); lung: 54.6429% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.2650% (minimum 97%, Baseline (adaptation disabled)); midbrain: 49.1961% (minimum 99%, Baseline (adaptation disabled)); pancreas: 49.5146% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 44.3478% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.6099% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.7586% (minimum 97%, Baseline (adaptation disabled)); retina: 49.3548% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 47.2222% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 51.1706% (minimum 99%, Baseline (adaptation disabled)); skin: 58.3969% (minimum 95%, Baseline (adaptation disabled)); small intestine: 42.8571% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.0896% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 47.8125% (minimum 99%, Baseline (adaptation disabled)); spleen: 46.7890% (minimum 95%, Baseline (adaptation disabled)); stomach: 51.6892% (minimum 97%, Baseline (adaptation disabled)); thymus: 44.7368% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 39.5349% (minimum 95%, Baseline (adaptation disabled)); tongue: 48.8818% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.4576% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,27.3,19.2,23.4,"heart muscle: 27.3 nTPM (vital, limit 1); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 1); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 2); thymus: 18.9 nTPM (manageable, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); spleen: 17.4 nTPM (manageable, limit 5); duodenum: 17.1 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 2); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 2); tongue: 16 nTPM (protected, limit 2); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 2); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 2); rectum: 13.7 nTPM (protected, limit 2); adipose tissue: 13.2 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 2); urinary bladder: 11.8 nTPM (protected, limit 2); smooth muscle: 11.5 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000180628,PCGF5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.554651,-0.526522,-0.630845
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6842% (minimum 90%, Approved); adrenal gland: 42.0330% (minimum 98%, Approved); amygdala: 50.3289% (minimum 99%, Missing); basal ganglia: 53.6842% (minimum 99%, Missing); bone marrow: 72.8571% (minimum 98%, Approved); cerebellum: 61.2000% (minimum 99%, Missing); cerebral cortex: 45.9459% (minimum 99%, Missing); choroid plexus: 76.5000% (minimum 99%, Missing); colon: 50.8306% (minimum 95%, Approved); duodenum: 47.2222% (minimum 99%, Missing); esophagus: 55.2347% (minimum 97%, Missing); heart muscle: 35.9155% (minimum 98%, Approved); hippocampal formation: 54.8387% (minimum 99%, Missing); hypothalamus: 50.6623% (minimum 99%, Missing); kidney: 40.3694% (minimum 99%, Missing); liver: 37.5921% (minimum 99%, Missing); lung: 54.6429% (minimum 98%, Approved); lymph node: 48.2650% (minimum 95%, Approved); midbrain: 49.1961% (minimum 99%, Missing); pancreas: 49.5146% (minimum 99%, Missing); parathyroid gland: 44.3478% (minimum 95%, Approved); pituitary gland: 68.6099% (minimum 99%, Missing); rectum: 52.7586% (minimum 95%, Approved); retina: 49.3548% (minimum 99%, Missing); salivary gland: 47.2222% (minimum 95%, Approved); skeletal muscle: 51.1706% (minimum 99%, Missing); skin: 58.3969% (minimum 95%, Missing); small intestine: 42.8571% (minimum 99%, Missing); smooth muscle: 57.0896% (minimum 98%, Approved); spinal cord: 47.8125% (minimum 99%, Missing); spleen: 46.7890% (minimum 90%, Approved); stomach: 51.6892% (minimum 97%, Missing); thymus: 44.7368% (minimum 95%, Missing); thyroid gland: 39.5349% (minimum 90%, Approved); tongue: 48.8818% (minimum 97%, Missing); urinary bladder: 56.4576% (minimum 97%, Missing)",0,7,partial,27.3,19.2,23.4,"heart muscle: 27.3 nTPM (vital, limit 2); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 10); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 2); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 4); thymus: 18.9 nTPM (manageable, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); spleen: 17.4 nTPM (manageable, limit 10); duodenum: 17.1 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 4); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 4); tongue: 16 nTPM (protected, limit 2); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 4); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 2); rectum: 13.7 nTPM (protected, limit 4); adipose tissue: 13.2 nTPM (manageable, limit 10); basal ganglia: 13.2 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 2); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 2); urinary bladder: 11.8 nTPM (protected, limit 2); smooth muscle: 11.5 nTPM (vital, limit 2); skin: 10.9 nTPM (manageable, limit 5); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 2); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,ENSG00000180628,PCGF5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.504651,-0.506522,-0.620845
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000180658,OR2A4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000180658,OR2A4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.22,-0.24
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"choroid plexus: 75.0000% (minimum 99%, Missing); duodenum: 75.0000% (minimum 99%, Missing); salivary gland: 75.0000% (minimum 97%, Missing)",0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000180658,OR2A4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.22,-0.24
True,compatible,,True,True,False,,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000180697,C3orf22,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000180697,C3orf22,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000180697,C3orf22,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,32.6,38,21.5,"stomach: 38 nTPM (protected, limit 2); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 2); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 2); thymus: 21.5 nTPM (manageable, limit 5); skin: 21.2 nTPM (manageable, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 2); colon: 16.2 nTPM (protected, limit 2); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (manageable, limit 5); spleen: 15.3 nTPM (manageable, limit 5); rectum: 15.2 nTPM (protected, limit 2); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 2); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000180776,ZDHHC20,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.9167% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.0870% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.0841% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.3659% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.2958% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.0841% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.0377% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.2761% (minimum 99%, Baseline (adaptation disabled)); colon: 63.3484% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.4752% (minimum 99%, Baseline (adaptation disabled)); esophagus: 49.2091% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.0960% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.2688% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.2943% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.3953% (minimum 99%, Baseline (adaptation disabled)); liver: 75.0670% (minimum 99%, Baseline (adaptation disabled)); lung: 63.4921% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.8102% (minimum 97%, Baseline (adaptation disabled)); midbrain: 65.7277% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.2943% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 76.7123% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.6873% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.8148% (minimum 97%, Baseline (adaptation disabled)); retina: 84.3373% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.3481% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.0503% (minimum 99%, Baseline (adaptation disabled)); skin: 56.9106% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.6061% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.1939% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 46.2046% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.6651% (minimum 95%, Baseline (adaptation disabled)); stomach: 42.4242% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.5657% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.0732% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.6757% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.2249% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,32.6,38,21.5,"stomach: 38 nTPM (protected, limit 2); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 2); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 2); thymus: 21.5 nTPM (manageable, limit 5); skin: 21.2 nTPM (manageable, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 2); colon: 16.2 nTPM (protected, limit 2); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (manageable, limit 5); spleen: 15.3 nTPM (manageable, limit 5); rectum: 15.2 nTPM (protected, limit 2); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 2); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000180776,ZDHHC20,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.384343,-0.545758,-0.527954
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 72.9167% (minimum 95%, Missing); adrenal gland: 76.0870% (minimum 99%, Missing); amygdala: 84.0841% (minimum 99%, Missing); basal ganglia: 85.3659% (minimum 99%, Missing); bone marrow: 49.2958% (minimum 99%, Missing); cerebellum: 84.0841% (minimum 99%, Missing); cerebral cortex: 66.0377% (minimum 99%, Missing); choroid plexus: 94.2761% (minimum 99%, Missing); colon: 63.3484% (minimum 97%, Missing); duodenum: 60.4752% (minimum 99%, Missing); esophagus: 49.2091% (minimum 97%, Missing); heart muscle: 79.0960% (minimum 99%, Missing); hippocampal formation: 75.2688% (minimum 99%, Missing); hypothalamus: 76.2943% (minimum 99%, Missing); kidney: 81.3953% (minimum 99%, Missing); liver: 75.0670% (minimum 99%, Missing); lung: 63.4921% (minimum 99%, Missing); lymph node: 61.8102% (minimum 97%, Missing); midbrain: 65.7277% (minimum 99%, Missing); pancreas: 76.2943% (minimum 99%, Missing); parathyroid gland: 76.7123% (minimum 97%, Missing); pituitary gland: 86.6873% (minimum 99%, Missing); rectum: 64.8148% (minimum 97%, Missing); retina: 84.3373% (minimum 99%, Missing); salivary gland: 77.3481% (minimum 97%, Missing); skeletal muscle: 88.0503% (minimum 99%, Missing); skin: 56.9106% (minimum 95%, Missing); small intestine: 60.6061% (minimum 99%, Missing); smooth muscle: 66.1939% (minimum 99%, Missing); spinal cord: 46.2046% (minimum 99%, Missing); spleen: 64.6651% (minimum 95%, Missing); stomach: 42.4242% (minimum 97%, Missing); thymus: 56.5657% (minimum 95%, Missing); thyroid gland: 64.0732% (minimum 95%, Missing); tongue: 75.6757% (minimum 97%, Missing); urinary bladder: 56.2249% (minimum 97%, Missing)",0,3,partial,32.6,38,21.5,"stomach: 38 nTPM (protected, limit 2); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 2); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 2); thymus: 21.5 nTPM (manageable, limit 5); skin: 21.2 nTPM (manageable, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 2); colon: 16.2 nTPM (protected, limit 2); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (manageable, limit 5); spleen: 15.3 nTPM (manageable, limit 5); rectum: 15.2 nTPM (protected, limit 2); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); adrenal gland: 8.8 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 2); salivary gland: 8.2 nTPM (protected, limit 2); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000180776,ZDHHC20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.384343,-0.545758,-0.527954
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000180872,DEFB112,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000180872,DEFB112,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000180872,DEFB112,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,1.4,0.3,1.5,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000180878,C11orf42,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 96.4844% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.8627% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.4844% (minimum 99%, Baseline (adaptation disabled)); retina: 94.6360% (minimum 99%, Baseline (adaptation disabled)); skin: 94.2748% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.2441% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.4,0.3,1.5,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000180878,C11orf42,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,-0.00725191,0.018,-0.0436398
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 94.6360% (minimum 99%, Missing)",0,3,partial,1.4,0.3,1.5,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000180878,C11orf42,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.03,-0.0436398
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,False,,9,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen,ENSG00000180934,OR56A1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,"bone marrow: 50.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 66.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled))",9,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen,ENSG00000180934,OR56A1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,-0.303333,-0.49
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,"bone marrow: 50.0000% (minimum 99%, Missing); liver: 66.6667% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); spleen: 66.6667% (minimum 95%, Missing)",9,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen,ENSG00000180934,OR56A1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,-0.303333,-0.49
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,1.8,1.8,1.8,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000180938,ZNF572,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.3659% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.1053% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.2222% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.7436% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.7778% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.3953% (minimum 99%, Baseline (adaptation disabled)); colon: 77.7778% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.5455% (minimum 99%, Baseline (adaptation disabled)); esophagus: 87.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.5455% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.3659% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.3659% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.6275% (minimum 99%, Baseline (adaptation disabled)); liver: 79.5455% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.0377% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.7778% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.5000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.1053% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.9167% (minimum 97%, Baseline (adaptation disabled)); retina: 66.0377% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.9167% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.5946% (minimum 99%, Baseline (adaptation disabled)); skin: 81.3953% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.5455% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.3953% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.7778% (minimum 99%, Baseline (adaptation disabled)); spleen: 71.4286% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.4286% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.0377% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 67.3077% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.5946% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.0870% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,1.8,1.8,1.8,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000180938,ZNF572,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.289623,-0.309623,-0.329623
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.3659% (minimum 90%, Approved); adrenal gland: 92.1053% (minimum 99%, Missing); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 97.2222% (minimum 98%, Approved); cerebellum: 89.7436% (minimum 99%, Missing); cerebral cortex: 77.7778% (minimum 99%, Missing); choroid plexus: 81.3953% (minimum 99%, Missing); colon: 77.7778% (minimum 97%, Missing); duodenum: 79.5455% (minimum 99%, Missing); esophagus: 87.5000% (minimum 97%, Missing); heart muscle: 79.5455% (minimum 99%, Missing); hippocampal formation: 85.3659% (minimum 99%, Missing); hypothalamus: 85.3659% (minimum 99%, Missing); kidney: 68.6275% (minimum 99%, Missing); liver: 79.5455% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 66.0377% (minimum 95%, Approved); midbrain: 83.3333% (minimum 99%, Missing); pancreas: 77.7778% (minimum 99%, Missing); parathyroid gland: 87.5000% (minimum 97%, Missing); pituitary gland: 92.1053% (minimum 99%, Missing); rectum: 72.9167% (minimum 97%, Missing); retina: 66.0377% (minimum 99%, Missing); salivary gland: 72.9167% (minimum 97%, Missing); skeletal muscle: 94.5946% (minimum 98%, Approved); skin: 81.3953% (minimum 95%, Missing); small intestine: 79.5455% (minimum 99%, Missing); smooth muscle: 81.3953% (minimum 99%, Missing); spinal cord: 77.7778% (minimum 99%, Missing); spleen: 71.4286% (minimum 90%, Approved); stomach: 71.4286% (minimum 97%, Missing); thymus: 66.0377% (minimum 95%, Missing); thyroid gland: 67.3077% (minimum 95%, Missing); tongue: 94.5946% (minimum 97%, Missing); urinary bladder: 76.0870% (minimum 97%, Missing)",0,1,partial,1.8,1.8,1.8,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000180938,ZNF572,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.289623,-0.289623,-0.329623
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.6,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180974,OR52E4,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 71.4286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.3333% (minimum 99%, Baseline (adaptation disabled)); duodenum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.3333% (minimum 97%, Baseline (adaptation disabled)); pancreas: 83.3333% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); rectum: 83.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 45.4545% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); skin: 55.5556% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.3333% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 62.5000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180974,OR52E4,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.394444,-0.136667,-0.535455
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adrenal gland: 83.3333% (minimum 99%, Missing); bone marrow: 71.4286% (minimum 99%, Missing); cerebral cortex: 83.3333% (minimum 99%, Missing); duodenum: 83.3333% (minimum 99%, Missing); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 83.3333% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lymph node: 83.3333% (minimum 97%, Missing); pancreas: 83.3333% (minimum 99%, Missing); parathyroid gland: 83.3333% (minimum 97%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 45.4545% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 71.4286% (minimum 99%, Missing); skin: 55.5556% (minimum 95%, Missing); small intestine: 83.3333% (minimum 99%, Missing); spleen: 83.3333% (minimum 95%, Missing); stomach: 83.3333% (minimum 97%, Missing); thyroid gland: 62.5000% (minimum 95%, Missing)",0,80,unavailable,0.6,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000180974,OR52E4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.394444,-0.136667,-0.535455
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,16.8,3.2,0.6,"heart muscle: 16.8 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,ENSG00000180999,C1orf105,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.0657% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 60.2837% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0769% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.5056% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.1493% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.7011% (minimum 99%, Baseline (adaptation disabled)); tongue: 88.8502% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,16.8,3.2,0.6,"heart muscle: 16.8 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,ENSG00000180999,C1orf105,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0270115,-0.0814983,-0.387163
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.0657% (minimum 99%, Missing); heart muscle: 60.2837% (minimum 99%, Missing); pancreas: 98.0769% (minimum 99%, Missing); salivary gland: 95.5056% (minimum 97%, Missing); skeletal muscle: 95.1493% (minimum 99%, Missing); small intestine: 97.7011% (minimum 99%, Missing); tongue: 88.8502% (minimum 97%, Missing)",0,80,unavailable,16.8,3.2,0.6,"heart muscle: 16.8 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,ENSG00000180999,C1orf105,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0270115,-0.0814983,-0.387163
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,108.4,83.2,87.8,"skeletal muscle: 108.4 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); skin: 87.8 nTPM (manageable, limit 5); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 2); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); salivary gland: 62.9 nTPM (protected, limit 2); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); spleen: 59.1 nTPM (manageable, limit 5); adipose tissue: 57.1 nTPM (manageable, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 2); thyroid gland: 54.3 nTPM (manageable, limit 5); urinary bladder: 53.7 nTPM (protected, limit 2); colon: 51.4 nTPM (protected, limit 2); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 2); lymph node: 22.8 nTPM (protected, limit 2); parathyroid gland: 19.1 nTPM (protected, limit 2); thymus: 16.3 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000181029,TRAPPC5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.5460% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.7159% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.0058% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 63.4076% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 73.9003% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.4304% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.5208% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.7171% (minimum 99%, Baseline (adaptation disabled)); colon: 77.4363% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.8538% (minimum 99%, Baseline (adaptation disabled)); esophagus: 67.9507% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.4076% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.5208% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.4312% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.5600% (minimum 99%, Baseline (adaptation disabled)); liver: 64.4737% (minimum 99%, Baseline (adaptation disabled)); lung: 83.5227% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.5542% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.5315% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.0132% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.2302% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.6432% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.6098% (minimum 97%, Baseline (adaptation disabled)); retina: 95.2998% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.7150% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.9382% (minimum 99%, Baseline (adaptation disabled)); skin: 66.7676% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.8909% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.0299% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.4694% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.9045% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.9363% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.5413% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 76.4629% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.1111% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.6623% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,108.4,83.2,87.8,"skeletal muscle: 108.4 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); skin: 87.8 nTPM (manageable, limit 5); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 2); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); salivary gland: 62.9 nTPM (protected, limit 2); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); spleen: 59.1 nTPM (manageable, limit 5); adipose tissue: 57.1 nTPM (manageable, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 2); thyroid gland: 54.3 nTPM (manageable, limit 5); urinary bladder: 53.7 nTPM (protected, limit 2); colon: 51.4 nTPM (protected, limit 2); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 2); lymph node: 22.8 nTPM (protected, limit 2); parathyroid gland: 19.1 nTPM (protected, limit 2); thymus: 16.3 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000181029,TRAPPC5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.282324,-0.290493,-0.370618
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 75.5460% (minimum 95%, Uncertain); adrenal gland: 67.7159% (minimum 99%, Missing); amygdala: 64.0058% (minimum 99%, Missing); basal ganglia: 63.4076% (minimum 99%, Missing); bone marrow: 73.9003% (minimum 99%, Missing); cerebellum: 74.4304% (minimum 99%, Uncertain); cerebral cortex: 64.5208% (minimum 99%, Missing); choroid plexus: 66.7171% (minimum 99%, Missing); colon: 77.4363% (minimum 97%, Missing); duodenum: 86.8538% (minimum 99%, Missing); esophagus: 67.9507% (minimum 97%, Uncertain); heart muscle: 63.4076% (minimum 99%, Missing); hippocampal formation: 64.5208% (minimum 99%, Missing); hypothalamus: 67.4312% (minimum 99%, Missing); kidney: 70.5600% (minimum 99%, Missing); liver: 64.4737% (minimum 99%, Uncertain); lung: 83.5227% (minimum 99%, Missing); lymph node: 88.5542% (minimum 97%, Missing); midbrain: 68.5315% (minimum 99%, Missing); pancreas: 73.0132% (minimum 99%, Missing); parathyroid gland: 90.2302% (minimum 97%, Missing); pituitary gland: 75.6432% (minimum 99%, Missing); rectum: 95.6098% (minimum 97%, Missing); retina: 95.2998% (minimum 99%, Missing); salivary gland: 73.7150% (minimum 97%, Missing); skeletal muscle: 61.9382% (minimum 99%, Missing); skin: 66.7676% (minimum 95%, Missing); small intestine: 78.8909% (minimum 99%, Missing); smooth muscle: 94.0299% (minimum 99%, Uncertain); spinal cord: 73.4694% (minimum 99%, Missing); spleen: 74.9045% (minimum 95%, Missing); stomach: 75.9363% (minimum 97%, Missing); thymus: 91.5413% (minimum 95%, Missing); thyroid gland: 76.4629% (minimum 95%, Missing); tongue: 87.1111% (minimum 97%, Missing); urinary bladder: 76.6623% (minimum 97%, Uncertain)",0,1,partial,108.4,83.2,87.8,"skeletal muscle: 108.4 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); skin: 87.8 nTPM (manageable, limit 5); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 2); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); salivary gland: 62.9 nTPM (protected, limit 2); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); spleen: 59.1 nTPM (manageable, limit 5); adipose tissue: 57.1 nTPM (manageable, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 2); thyroid gland: 54.3 nTPM (manageable, limit 5); urinary bladder: 53.7 nTPM (protected, limit 2); colon: 51.4 nTPM (protected, limit 2); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 2); lymph node: 22.8 nTPM (protected, limit 2); parathyroid gland: 19.1 nTPM (protected, limit 2); thymus: 16.3 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000181029,TRAPPC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.282324,-0.290493,-0.370618
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,738.6,22.3,8.3,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 6); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 6); colon: 22.3 nTPM (protected, limit 2); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 6); tongue: 5.1 nTPM (protected, limit 2); hippocampal formation: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181195,PENK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 93.7921% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 25.5657% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.1264% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 14.5139% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.8726% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.5701% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.1221% (minimum 99%, Baseline (adaptation disabled)); colon: 84.9018% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.5443% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.4615% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.3755% (minimum 99%, Baseline (adaptation disabled)); lung: 97.2093% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.2847% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 88.3099% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.8159% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.8340% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.5358% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.1014% (minimum 99%, Baseline (adaptation disabled)); stomach: 92.8201% (minimum 97%, Baseline (adaptation disabled)); tongue: 96.0920% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,738.6,22.3,8.3,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 1); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 1); colon: 22.3 nTPM (protected, limit 2); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 2); adipose tissue: 8.3 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 2); hippocampal formation: 4.6 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); skeletal muscle: 2.8 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181195,PENK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0120793,-0.120982,-0.844861
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 25.5657% (minimum 99%, Missing); amygdala: 86.1264% (minimum 99%, Missing); basal ganglia: 14.5139% (minimum 99%, Missing); cerebellum: 79.8726% (minimum 95%, Enhanced); cerebral cortex: 94.5701% (minimum 95%, Enhanced); choroid plexus: 98.1221% (minimum 99%, Missing); colon: 84.9018% (minimum 97%, Missing); heart muscle: 83.5443% (minimum 95%, Enhanced); hippocampal formation: 96.4615% (minimum 99%, Missing); hypothalamus: 60.3755% (minimum 99%, Missing); midbrain: 97.2847% (minimum 99%, Missing); pituitary gland: 88.3099% (minimum 99%, Missing); small intestine: 96.8340% (minimum 99%, Missing); spinal cord: 83.1014% (minimum 99%, Missing); tongue: 96.0920% (minimum 97%, Missing)",0,7,partial,738.6,22.3,8.3,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 6); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 6); colon: 22.3 nTPM (protected, limit 2); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 6); tongue: 5.1 nTPM (protected, limit 2); hippocampal formation: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181195,PENK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0484076,-0.120982,-0.844861
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,12,partial,20.1,1.6,1.1,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181322,NME9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.0452% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.1887% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.8929% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.8586% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.0698% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.0698% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 45.8221% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.8372% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.1429% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.3410% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.0339% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.9721% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2659% (minimum 99%, Baseline (adaptation disabled)); lung: 89.0052% (minimum 99%, Baseline (adaptation disabled)); midbrain: 82.9268% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.4066% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.5056% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.5243% (minimum 99%, Baseline (adaptation disabled)); retina: 70.2479% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.3978% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.7347% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.5056% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.8372% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.1256% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.5909% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.9227% (minimum 95%, Baseline (adaptation disabled))",0,12,partial,20.1,1.6,1.1,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181322,NME9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0107735,-0.0560215,-0.531779
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.0452% (minimum 99%, Missing); amygdala: 80.1887% (minimum 99%, Missing); basal ganglia: 75.8929% (minimum 99%, Missing); bone marrow: 85.8586% (minimum 95%, Enhanced); cerebellum: 79.0698% (minimum 95%, Enhanced); cerebral cortex: 79.0698% (minimum 95%, Enhanced); choroid plexus: 45.8221% (minimum 99%, Missing); duodenum: 98.8372% (minimum 99%, Missing); hippocampal formation: 78.3410% (minimum 99%, Missing); hypothalamus: 72.0339% (minimum 99%, Missing); kidney: 94.9721% (minimum 95%, Enhanced); lung: 89.0052% (minimum 95%, Enhanced); midbrain: 82.9268% (minimum 99%, Missing); pancreas: 93.4066% (minimum 95%, Enhanced); pituitary gland: 82.5243% (minimum 99%, Missing); retina: 70.2479% (minimum 99%, Missing); skeletal muscle: 86.7347% (minimum 95%, Enhanced); small intestine: 95.5056% (minimum 99%, Missing); spinal cord: 82.1256% (minimum 99%, Missing); thyroid gland: 93.9227% (minimum 95%, Missing)",0,12,partial,20.1,1.6,1.1,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181322,NME9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0107735,0.00142857,-0.531779
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000181323,SPEM1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000181323,SPEM1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00701493
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000181323,SPEM1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00701493
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181371,OR5M8,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181371,OR5M8,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181371,OR5M8,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,ENSG00000181433,SAGE1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.9167% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.9184% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.9167% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.9167% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.9167% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.9167% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.9184% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,ENSG00000181433,SAGE1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,-0.0308163
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 97.9167% (minimum 99%, Missing); choroid plexus: 95.9184% (minimum 99%, Missing); hippocampal formation: 97.9167% (minimum 99%, Missing); hypothalamus: 97.9167% (minimum 99%, Missing); midbrain: 97.9167% (minimum 99%, Missing); pituitary gland: 97.9167% (minimum 99%, Missing); spinal cord: 95.9184% (minimum 99%, Missing)",0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,ENSG00000181433,SAGE1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,-0.0308163
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.7,4.4,5.3,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); tongue: 2.6 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181450,ZNF678,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.1212% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.7465% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.2143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.5455% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 53.9474% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 69.4915% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.8987% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 59.4203% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.0794% (minimum 99%, Baseline (adaptation disabled)); esophagus: 67.2131% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.4915% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.5455% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.9259% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.1212% (minimum 99%, Baseline (adaptation disabled)); liver: 66.1290% (minimum 99%, Baseline (adaptation disabled)); lung: 56.9444% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.2353% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.2143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.1644% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.0625% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.2143% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.2500% (minimum 97%, Baseline (adaptation disabled)); retina: 41.8367% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.2941% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 74.5455% (minimum 99%, Baseline (adaptation disabled)); skin: 73.2143% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.0794% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.0625% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.4915% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.2468% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.1644% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.8095% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 43.6170% (minimum 95%, Baseline (adaptation disabled)); tongue: 61.1940% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.1290% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.7,4.4,5.3,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); tongue: 2.6 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181450,ZNF678,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.51383,-0.487647,-0.571633
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.1212% (minimum 95%, Missing); adrenal gland: 57.7465% (minimum 99%, Missing); amygdala: 73.2143% (minimum 99%, Missing); basal ganglia: 74.5455% (minimum 99%, Missing); bone marrow: 53.9474% (minimum 99%, Missing); cerebellum: 69.4915% (minimum 99%, Missing); cerebral cortex: 51.8987% (minimum 99%, Missing); choroid plexus: 82.0000% (minimum 99%, Missing); colon: 59.4203% (minimum 97%, Missing); duodenum: 65.0794% (minimum 99%, Missing); esophagus: 67.2131% (minimum 97%, Missing); heart muscle: 69.4915% (minimum 99%, Missing); hippocampal formation: 74.5455% (minimum 99%, Missing); hypothalamus: 75.9259% (minimum 99%, Missing); kidney: 62.1212% (minimum 99%, Missing); liver: 66.1290% (minimum 99%, Missing); lung: 56.9444% (minimum 99%, Missing); lymph node: 48.2353% (minimum 97%, Missing); midbrain: 73.2143% (minimum 99%, Missing); pancreas: 56.1644% (minimum 99%, Missing); parathyroid gland: 64.0625% (minimum 97%, Missing); pituitary gland: 73.2143% (minimum 99%, Missing); rectum: 51.2500% (minimum 97%, Missing); retina: 41.8367% (minimum 99%, Missing); salivary gland: 60.2941% (minimum 97%, Missing); skeletal muscle: 74.5455% (minimum 99%, Missing); skin: 73.2143% (minimum 95%, Missing); small intestine: 65.0794% (minimum 99%, Missing); smooth muscle: 64.0625% (minimum 99%, Missing); spinal cord: 69.4915% (minimum 99%, Missing); spleen: 53.2468% (minimum 95%, Missing); stomach: 56.1644% (minimum 97%, Missing); thymus: 48.8095% (minimum 95%, Missing); thyroid gland: 43.6170% (minimum 95%, Missing); tongue: 61.1940% (minimum 97%, Missing); urinary bladder: 66.1290% (minimum 97%, Missing)",0,80,unavailable,5.7,4.4,5.3,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); tongue: 2.6 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181450,ZNF678,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.51383,-0.487647,-0.571633
True,compatible,,True,True,False,,0,0,routine_complete,0,0,0,,,54,not_established,not_triggered,,,ENSG00000181552,EDDM3B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,0,routine_complete,0,0,0,,,54,not_established,not_triggered,,,ENSG00000181552,EDDM3B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,0,routine_complete,0,0,0,,,54,not_established,not_triggered,,,ENSG00000181552,EDDM3B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,5,partial,0.7,0,0,,,53,not_established,not_triggered,,,ENSG00000181562,EDDM3A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
True,compatible,,True,True,True,,0,5,partial,0.7,0,0,,,53,not_established,not_triggered,,,ENSG00000181562,EDDM3A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,0.00887387
True,compatible,,True,True,True,,0,5,partial,0.7,0,0,,,53,not_established,not_triggered,,,ENSG00000181562,EDDM3A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,0.00967799
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181609,OR52D1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181609,OR52D1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181609,OR52D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181616,OR52H1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181616,OR52H1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181616,OR52H1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,3,partial,0.9,0.2,0,,,53,not_established,not_triggered,,,ENSG00000181626,ANKRD62,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 88.8889% (minimum 97%, Baseline (adaptation disabled)); pancreas: 64.0000% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.9,0.2,0,,,53,not_established,not_triggered,,,ENSG00000181626,ANKRD62,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.05,-0.0811111,-0.35
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 64.0000% (minimum 95%, Enhanced)",0,3,partial,0.9,0.2,0,,,53,not_established,not_triggered,,,ENSG00000181626,ANKRD62,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.05,0.03,-0.31
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,8.6,8.6,4.9,"tongue: 8.6 nTPM (protected, limit 2); retina: 8.6 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2); salivary gland: 3 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000181722,ZBTB20,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 78.8660% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.6875% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.2264% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.4444% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.1522% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.5325% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.5000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.4393% (minimum 99%, Baseline (adaptation disabled)); colon: 90.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.0311% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.7273% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.9524% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.8650% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.2264% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 73.9130% (minimum 99%, Baseline (adaptation disabled)); lung: 88.9535% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.9535% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.2264% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.8182% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.9318% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.1687% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.6168% (minimum 97%, Baseline (adaptation disabled)); retina: 64.0167% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.6066% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.6652% (minimum 99%, Baseline (adaptation disabled)); skin: 85.9551% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.0311% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.5304% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.0311% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.4749% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.4393% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.7426% (minimum 95%, Baseline (adaptation disabled)); tongue: 64.0167% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.5325% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,8.6,8.6,4.9,"tongue: 8.6 nTPM (protected, limit 2); retina: 8.6 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000181722,ZBTB20,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.192574,-0.329833,-0.349833
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 78.8660% (minimum 95%, Missing); adrenal gland: 79.6875% (minimum 99%, Missing); amygdala: 96.2264% (minimum 99%, Missing); basal ganglia: 94.4444% (minimum 99%, Missing); bone marrow: 83.1522% (minimum 98%, Approved); cerebellum: 90.5325% (minimum 99%, Missing); cerebral cortex: 76.5000% (minimum 99%, Missing); choroid plexus: 88.4393% (minimum 99%, Missing); colon: 90.0000% (minimum 97%, Missing); duodenum: 95.0311% (minimum 98%, Approved); esophagus: 92.7273% (minimum 95%, Approved); heart muscle: 80.9524% (minimum 99%, Missing); hippocampal formation: 93.8650% (minimum 99%, Missing); hypothalamus: 96.2264% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 73.9130% (minimum 99%, Missing); lung: 88.9535% (minimum 99%, Missing); lymph node: 88.9535% (minimum 97%, Missing); midbrain: 96.2264% (minimum 99%, Missing); pancreas: 81.8182% (minimum 99%, Missing); parathyroid gland: 86.9318% (minimum 97%, Missing); pituitary gland: 92.1687% (minimum 99%, Missing); rectum: 91.6168% (minimum 95%, Approved); retina: 64.0167% (minimum 99%, Missing); salivary gland: 83.6066% (minimum 97%, Missing); skeletal muscle: 65.6652% (minimum 99%, Missing); skin: 85.9551% (minimum 95%, Missing); small intestine: 95.0311% (minimum 98%, Approved); smooth muscle: 84.5304% (minimum 99%, Missing); spinal cord: 95.0311% (minimum 99%, Missing); spleen: 85.4749% (minimum 95%, Missing); stomach: 90.0000% (minimum 95%, Approved); thymus: 88.4393% (minimum 95%, Missing); thyroid gland: 75.7426% (minimum 95%, Missing); tongue: 64.0167% (minimum 97%, Missing); urinary bladder: 90.5325% (minimum 97%, Missing)",0,3,partial,8.6,8.6,4.9,"tongue: 8.6 nTPM (protected, limit 2); retina: 8.6 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2); salivary gland: 3 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000181722,ZBTB20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.192574,-0.329833,-0.349833
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8,0.2,0.7,"skeletal muscle: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000181781,CIMAP1D,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.7013% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.2759% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2759% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7013% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2759% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2759% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7013% (minimum 99%, Baseline (adaptation disabled)); liver: 98.7013% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.8541% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 74.0260% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.0213% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,8,0.2,0.7,"skeletal muscle: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000181781,CIMAP1D,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0202128,0.0213043,-0.24974
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.7013% (minimum 99%, Missing); amygdala: 98.2759% (minimum 99%, Missing); basal ganglia: 98.2759% (minimum 99%, Missing); cerebral cortex: 98.7013% (minimum 99%, Missing); heart muscle: 98.2759% (minimum 99%, Missing); hippocampal formation: 98.2759% (minimum 99%, Missing); hypothalamus: 98.7013% (minimum 99%, Missing); liver: 98.7013% (minimum 99%, Missing); midbrain: 97.8541% (minimum 99%, Missing); skeletal muscle: 74.0260% (minimum 99%, Missing); spinal cord: 97.0213% (minimum 99%, Missing)",0,80,unavailable,8,0.2,0.7,"skeletal muscle: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000181781,CIMAP1D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0202128,0.0213043,-0.24974
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181786,ACTL9,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181786,ACTL9,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181786,ACTL9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,11,partial,8.8,5.6,11.2,"thymus: 11.2 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 2); lymph node: 5.5 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); stomach: 3 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000181827,RFX7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.4035% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.6517% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.9231% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.6316% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.9469% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); colon: 73.6842% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.4035% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.1649% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.6517% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.9231% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.0870% (minimum 99%, Baseline (adaptation disabled)); liver: 72.9167% (minimum 99%, Baseline (adaptation disabled)); lung: 69.3069% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.6517% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.9167% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.2202% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.9167% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.3069% (minimum 97%, Baseline (adaptation disabled)); retina: 44.3038% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.3597% (minimum 99%, Baseline (adaptation disabled)); skin: 52.6316% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.3077% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.9231% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.4035% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 38.4615% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.7071% (minimum 95%, Baseline (adaptation disabled)); tongue: 55.5556% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.3077% (minimum 97%, Baseline (adaptation disabled))",0,11,partial,8.8,5.6,11.2,"thymus: 11.2 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 2); lymph node: 5.5 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); stomach: 3 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000181827,RFX7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.565385,-0.414444,-0.546962
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4286% (minimum 90%, Approved); adrenal gland: 61.4035% (minimum 99%, Missing); amygdala: 78.6517% (minimum 99%, Missing); basal ganglia: 76.9231% (minimum 99%, Missing); bone marrow: 52.6316% (minimum 99%, Missing); cerebellum: 56.0000% (minimum 99%, Missing); cerebral cortex: 61.9469% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); colon: 73.6842% (minimum 97%, Missing); duodenum: 61.4035% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 72.1649% (minimum 98%, Approved); hippocampal formation: 78.6517% (minimum 99%, Missing); hypothalamus: 76.9231% (minimum 99%, Missing); kidney: 76.0870% (minimum 99%, Missing); liver: 72.9167% (minimum 99%, Missing); lung: 69.3069% (minimum 99%, Missing); lymph node: 56.0000% (minimum 97%, Missing); midbrain: 78.6517% (minimum 99%, Missing); pancreas: 72.9167% (minimum 99%, Missing); parathyroid gland: 64.2202% (minimum 97%, Missing); pituitary gland: 72.9167% (minimum 99%, Missing); rectum: 69.3069% (minimum 97%, Missing); retina: 44.3038% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 50.3597% (minimum 99%, Missing); skin: 52.6316% (minimum 95%, Missing); small intestine: 67.3077% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 76.9231% (minimum 99%, Missing); spleen: 61.4035% (minimum 95%, Missing); stomach: 70.0000% (minimum 97%, Missing); thymus: 38.4615% (minimum 95%, Missing); thyroid gland: 70.7071% (minimum 95%, Missing); tongue: 55.5556% (minimum 97%, Missing); urinary bladder: 67.3077% (minimum 97%, Missing)",0,11,partial,8.8,5.6,11.2,"thymus: 11.2 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 2); lymph node: 5.5 nTPM (protected, limit 2); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); stomach: 3 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000181827,RFX7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.565385,-0.414444,-0.546962
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181867,FTMT,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181867,FTMT,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181867,FTMT,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,5.8,3.8,2.9,"skeletal muscle: 5.8 nTPM (vital, limit 2); bone marrow: 4.1 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); heart muscle: 3.2 nTPM (vital, limit 2); pancreas: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 2); cerebellum: 2.3 nTPM (vital, limit 2); parathyroid gland: 2.1 nTPM (protected, limit 2); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000181873,IBA57,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6486% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 40.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 60.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.0645% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 30.5085% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.9024% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 52.9412% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 54.5455% (minimum 99%, Baseline (adaptation disabled)); colon: 51.4286% (minimum 97%, Baseline (adaptation disabled)); duodenum: 52.9412% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.9412% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 36.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 62.0690% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.6486% (minimum 99%, Baseline (adaptation disabled)); liver: 40.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 48.6486% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.9412% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.0690% (minimum 99%, Baseline (adaptation disabled)); pancreas: 39.1304% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 46.1538% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.0645% (minimum 97%, Baseline (adaptation disabled)); retina: 60.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.4286% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 23.6842% (minimum 99%, Baseline (adaptation disabled)); skin: 38.2979% (minimum 95%, Baseline (adaptation disabled)); small intestine: 52.9412% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 52.9412% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 51.4286% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.6486% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.0645% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.0645% (minimum 95%, Baseline (adaptation disabled)); tongue: 32.1429% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.0645% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,5.8,3.8,2.9,"skeletal muscle: 5.8 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); heart muscle: 3.2 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000181873,IBA57,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.567021,-0.648571,-0.753158
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6486% (minimum 90%, Approved); adrenal gland: 40.0000% (minimum 99%, Missing); amygdala: 60.0000% (minimum 99%, Missing); basal ganglia: 58.0645% (minimum 99%, Missing); bone marrow: 30.5085% (minimum 99%, Missing); cerebellum: 43.9024% (minimum 98%, Approved); cerebral cortex: 52.9412% (minimum 98%, Approved); choroid plexus: 54.5455% (minimum 99%, Missing); colon: 51.4286% (minimum 97%, Missing); duodenum: 52.9412% (minimum 98%, Approved); esophagus: 52.9412% (minimum 95%, Approved); heart muscle: 36.0000% (minimum 98%, Approved); hippocampal formation: 62.0690% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 48.6486% (minimum 99%, Missing); liver: 40.0000% (minimum 98%, Approved); lung: 48.6486% (minimum 99%, Missing); lymph node: 52.9412% (minimum 97%, Missing); midbrain: 62.0690% (minimum 99%, Missing); pancreas: 39.1304% (minimum 99%, Missing); parathyroid gland: 46.1538% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 58.0645% (minimum 97%, Missing); retina: 60.0000% (minimum 99%, Missing); salivary gland: 51.4286% (minimum 97%, Missing); skeletal muscle: 23.6842% (minimum 98%, Approved); skin: 38.2979% (minimum 95%, Missing); small intestine: 52.9412% (minimum 99%, Missing); smooth muscle: 52.9412% (minimum 98%, Approved); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 51.4286% (minimum 95%, Missing); stomach: 48.6486% (minimum 97%, Missing); thymus: 58.0645% (minimum 95%, Missing); thyroid gland: 58.0645% (minimum 90%, Approved); tongue: 32.1429% (minimum 97%, Missing); urinary bladder: 58.0645% (minimum 95%, Approved)",0,3,partial,5.8,3.8,2.9,"skeletal muscle: 5.8 nTPM (vital, limit 2); bone marrow: 4.1 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); heart muscle: 3.2 nTPM (vital, limit 2); pancreas: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 2); cerebellum: 2.3 nTPM (vital, limit 2); parathyroid gland: 2.1 nTPM (protected, limit 2); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000181873,IBA57,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.567021,-0.648571,-0.743158
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,13.4,26.8,24.6,"lymph node: 26.8 nTPM (protected, limit 2); thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181896,ZNF101,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.8657% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.7398% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.4688% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.1024% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 43.4599% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.7460% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.8450% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.4436% (minimum 99%, Baseline (adaptation disabled)); colon: 69.1275% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.8657% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.5882% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.0645% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.4436% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.1024% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.0280% (minimum 99%, Baseline (adaptation disabled)); liver: 77.4436% (minimum 99%, Baseline (adaptation disabled)); lung: 75.7353% (minimum 99%, Baseline (adaptation disabled)); lymph node: 27.7628% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.8450% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.7460% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.4262% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.1240% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.0680% (minimum 97%, Baseline (adaptation disabled)); retina: 71.5278% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.4436% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.8333% (minimum 99%, Baseline (adaptation disabled)); skin: 74.1007% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.5934% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.7398% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.2308% (minimum 99%, Baseline (adaptation disabled)); spleen: 49.0476% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.0680% (minimum 97%, Baseline (adaptation disabled)); thymus: 29.5129% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 77.4436% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.7931% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.6051% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,13.4,26.8,24.6,"lymph node: 26.8 nTPM (protected, limit 2); thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181896,ZNF101,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.654871,-0.692372,-0.555401
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.8657% (minimum 95%, Missing); adrenal gland: 83.7398% (minimum 99%, Missing); amygdala: 80.4688% (minimum 99%, Missing); basal ganglia: 81.1024% (minimum 99%, Missing); bone marrow: 43.4599% (minimum 99%, Missing); cerebellum: 81.7460% (minimum 99%, Missing); cerebral cortex: 79.8450% (minimum 99%, Missing); choroid plexus: 77.4436% (minimum 99%, Missing); colon: 69.1275% (minimum 97%, Missing); duodenum: 76.8657% (minimum 99%, Missing); esophagus: 60.5882% (minimum 97%, Missing); heart muscle: 83.0645% (minimum 99%, Missing); hippocampal formation: 77.4436% (minimum 99%, Missing); hypothalamus: 81.1024% (minimum 99%, Missing); kidney: 72.0280% (minimum 99%, Missing); liver: 77.4436% (minimum 99%, Missing); lung: 75.7353% (minimum 99%, Missing); lymph node: 27.7628% (minimum 97%, Missing); midbrain: 79.8450% (minimum 99%, Missing); pancreas: 81.7460% (minimum 99%, Missing); parathyroid gland: 84.4262% (minimum 97%, Missing); pituitary gland: 85.1240% (minimum 99%, Missing); rectum: 70.0680% (minimum 97%, Missing); retina: 71.5278% (minimum 99%, Missing); salivary gland: 77.4436% (minimum 97%, Missing); skeletal muscle: 85.8333% (minimum 99%, Missing); skin: 74.1007% (minimum 95%, Missing); small intestine: 56.5934% (minimum 99%, Missing); smooth muscle: 83.7398% (minimum 99%, Missing); spinal cord: 79.2308% (minimum 99%, Missing); spleen: 49.0476% (minimum 95%, Missing); stomach: 70.0680% (minimum 97%, Missing); thymus: 29.5129% (minimum 95%, Missing); thyroid gland: 77.4436% (minimum 95%, Missing); tongue: 88.7931% (minimum 97%, Missing); urinary bladder: 65.6051% (minimum 97%, Missing)",0,80,unavailable,13.4,26.8,24.6,"lymph node: 26.8 nTPM (protected, limit 2); thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 2); urinary bladder: 5.4 nTPM (protected, limit 2); colon: 4.6 nTPM (protected, limit 2); stomach: 4.4 nTPM (protected, limit 2); rectum: 4.4 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000181896,ZNF101,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.654871,-0.692372,-0.555401
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,41.9,25.9,28.9,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (manageable, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 2); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 2); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (manageable, limit 10); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 2); skeletal muscle: 20.7 nTPM (vital, limit 1); colon: 20.5 nTPM (protected, limit 2); hippocampal formation: 20.3 nTPM (vital, limit 1); esophagus: 20.3 nTPM (protected, limit 2); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); skin: 18.6 nTPM (manageable, limit 5); midbrain: 18.1 nTPM (vital, limit 1); salivary gland: 17.8 nTPM (protected, limit 2); rectum: 17.8 nTPM (protected, limit 2); small intestine: 16.7 nTPM (vital, limit 1); spleen: 16.2 nTPM (manageable, limit 5); lymph node: 15.9 nTPM (protected, limit 2); stomach: 15.7 nTPM (protected, limit 2); pituitary gland: 15 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000181904,C5orf24,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7758% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 52.8195% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.5339% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.7540% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 53.2197% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.9750% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.2197% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.3785% (minimum 99%, Baseline (adaptation disabled)); colon: 57.8189% (minimum 97%, Baseline (adaptation disabled)); duodenum: 56.6532% (minimum 99%, Baseline (adaptation disabled)); esophagus: 58.0579% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.9147% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.0579% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.9099% (minimum 99%, Baseline (adaptation disabled)); kidney: 41.5066% (minimum 99%, Baseline (adaptation disabled)); liver: 40.1429% (minimum 99%, Baseline (adaptation disabled)); lung: 55.8648% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.8636% (minimum 97%, Baseline (adaptation disabled)); midbrain: 60.8225% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.7042% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.0370% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 65.1972% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.2200% (minimum 97%, Baseline (adaptation disabled)); retina: 60.0427% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.2200% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 57.5820% (minimum 99%, Baseline (adaptation disabled)); skin: 60.1713% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.7232% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 52.2305% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.0891% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.4312% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.1553% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.8080% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 49.2982% (minimum 95%, Baseline (adaptation disabled)); tongue: 52.3277% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.7677% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,41.9,25.9,28.9,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (manageable, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 2); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 2); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (manageable, limit 5); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 2); skeletal muscle: 20.7 nTPM (vital, limit 1); colon: 20.5 nTPM (protected, limit 2); hippocampal formation: 20.3 nTPM (vital, limit 1); esophagus: 20.3 nTPM (protected, limit 2); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); skin: 18.6 nTPM (manageable, limit 5); midbrain: 18.1 nTPM (vital, limit 1); salivary gland: 17.8 nTPM (protected, limit 2); rectum: 17.8 nTPM (protected, limit 2); small intestine: 16.7 nTPM (vital, limit 1); spleen: 16.2 nTPM (manageable, limit 5); lymph node: 15.9 nTPM (protected, limit 2); stomach: 15.7 nTPM (protected, limit 2); pituitary gland: 15 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000181904,C5orf24,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.457018,-0.44963,-0.588571
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7758% (minimum 90%, Approved); adrenal gland: 52.8195% (minimum 99%, Missing); amygdala: 59.5339% (minimum 99%, Missing); basal ganglia: 55.7540% (minimum 99%, Missing); bone marrow: 53.2197% (minimum 99%, Missing); cerebellum: 43.9750% (minimum 99%, Missing); cerebral cortex: 53.2197% (minimum 99%, Missing); choroid plexus: 79.3785% (minimum 99%, Missing); colon: 57.8189% (minimum 97%, Missing); duodenum: 56.6532% (minimum 99%, Missing); esophagus: 58.0579% (minimum 97%, Missing); heart muscle: 59.9147% (minimum 99%, Missing); hippocampal formation: 58.0579% (minimum 99%, Missing); hypothalamus: 58.9099% (minimum 99%, Missing); kidney: 41.5066% (minimum 99%, Missing); liver: 40.1429% (minimum 99%, Missing); lung: 55.8648% (minimum 99%, Missing); lymph node: 63.8636% (minimum 97%, Missing); midbrain: 60.8225% (minimum 99%, Missing); pancreas: 68.7042% (minimum 99%, Missing); parathyroid gland: 52.0370% (minimum 97%, Missing); pituitary gland: 65.1972% (minimum 99%, Missing); rectum: 61.2200% (minimum 97%, Missing); retina: 60.0427% (minimum 99%, Missing); salivary gland: 61.2200% (minimum 97%, Missing); skeletal muscle: 57.5820% (minimum 99%, Missing); skin: 60.1713% (minimum 95%, Missing); small intestine: 62.7232% (minimum 99%, Missing); smooth muscle: 52.2305% (minimum 99%, Missing); spinal cord: 50.0891% (minimum 99%, Missing); spleen: 63.4312% (minimum 95%, Missing); stomach: 64.1553% (minimum 97%, Missing); thymus: 65.8080% (minimum 95%, Missing); thyroid gland: 49.2982% (minimum 95%, Missing); tongue: 52.3277% (minimum 97%, Missing); urinary bladder: 56.7677% (minimum 97%, Missing)",0,3,partial,41.9,25.9,28.9,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (manageable, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 2); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 2); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (manageable, limit 10); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 2); skeletal muscle: 20.7 nTPM (vital, limit 1); colon: 20.5 nTPM (protected, limit 2); hippocampal formation: 20.3 nTPM (vital, limit 1); esophagus: 20.3 nTPM (protected, limit 2); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); skin: 18.6 nTPM (manageable, limit 5); midbrain: 18.1 nTPM (vital, limit 1); salivary gland: 17.8 nTPM (protected, limit 2); rectum: 17.8 nTPM (protected, limit 2); small intestine: 16.7 nTPM (vital, limit 1); spleen: 16.2 nTPM (manageable, limit 5); lymph node: 15.9 nTPM (protected, limit 2); stomach: 15.7 nTPM (protected, limit 2); pituitary gland: 15 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000181904,C5orf24,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.457018,-0.44963,-0.588571
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181961,OR4A16,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181961,OR4A16,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000181961,OR4A16,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,ENSG00000181965,NEUROG1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,ENSG00000181965,NEUROG1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,ENSG00000181965,NEUROG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,80,unavailable,0.3,0,1,,,0,not_established,not_triggered,,,ENSG00000182035,ADIG,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.3,0,1,,,0,not_established,not_triggered,,,ENSG00000182035,ADIG,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0311321,0.03,0.00426386
True,compatible,,True,True,True,,0,80,unavailable,0.3,0,1,,,0,not_established,not_triggered,,,ENSG00000182035,ADIG,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0311321,0.03,0.00426386
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,4.4,0.4,5.8,"basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin 1 / keratinocytes; skin 2 / epidermal cells,ENSG00000182050,MGAT4C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 93.8776% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.1429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.0137% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 51.1111% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.7925% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.7901% (minimum 99%, Baseline (adaptation disabled)); colon: 92.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.1935% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.0159% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.8723% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8723% (minimum 99%, Baseline (adaptation disabled)); lung: 97.8723% (minimum 99%, Baseline (adaptation disabled)); midbrain: 69.6970% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.8723% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 59.7403% (minimum 99%, Baseline (adaptation disabled)); retina: 92.0000% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.8723% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.8723% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.1852% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 44.2308% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,4.4,0.4,5.8,"thyroid gland: 5.8 nTPM (manageable, limit 5); basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin 1 / keratinocytes; skin 2 / epidermal cells,ENSG00000182050,MGAT4C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.507692,-0.05,-0.478889
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 82.1429% (minimum 98%, Approved); amygdala: 63.0137% (minimum 99%, Missing); basal ganglia: 51.1111% (minimum 99%, Missing); cerebellum: 86.7925% (minimum 98%, Approved); cerebral cortex: 56.7901% (minimum 98%, Approved); colon: 92.0000% (minimum 97%, Missing); heart muscle: 74.1935% (minimum 99%, Missing); hippocampal formation: 73.0159% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 97.8723% (minimum 99%, Missing); liver: 97.8723% (minimum 98%, Approved); lung: 97.8723% (minimum 98%, Approved); midbrain: 69.6970% (minimum 99%, Missing); pancreas: 97.8723% (minimum 98%, Approved); pituitary gland: 59.7403% (minimum 99%, Missing); retina: 92.0000% (minimum 99%, Missing); small intestine: 97.8723% (minimum 99%, Missing); smooth muscle: 97.8723% (minimum 98%, Approved); spinal cord: 85.1852% (minimum 99%, Missing); thyroid gland: 44.2308% (minimum 90%, Approved)",0,4,partial,4.4,0.4,5.8,"basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin 1 / keratinocytes; skin 2 / epidermal cells,ENSG00000182050,MGAT4C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.457692,-0.05,-0.478889
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182053,TRIM49B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182053,TRIM49B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182053,TRIM49B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000182083,OR6B2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 57.1429% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000182083,OR6B2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.418571
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 57.1429% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000182083,OR6B2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.418571
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000182111,ZNF716,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41388-018-0357-2,Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 80.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000182111,ZNF716,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41388-018-0357-2,Wang 2016;Bruggeman 2018,0.05,0.03,-0.19
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 80.0000% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000182111,ZNF716,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41388-018-0357-2,Wang 2016;Bruggeman 2018,0.05,0.03,-0.19
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,13.1,29.1,9.8,"parathyroid gland: 29.1 nTPM (protected, limit 2); cerebellum: 13.1 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 2); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); hippocampal formation: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); amygdala: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182134,TDRKH,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.9582% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.7551% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.7546% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.6296% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.8865% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.1387% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.1379% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.4774% (minimum 99%, Baseline (adaptation disabled)); colon: 87.3984% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.7173% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.6724% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.3454% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.4672% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.9129% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.6457% (minimum 99%, Baseline (adaptation disabled)); liver: 86.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 83.6576% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.7546% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.5125% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.1148% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 42.4901% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.6923% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.6457% (minimum 97%, Baseline (adaptation disabled)); retina: 69.8052% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.9717% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.9844% (minimum 99%, Baseline (adaptation disabled)); skin: 90.7173% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.1017% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.8430% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.5125% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.8986% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.4774% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.6901% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.1748% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.0611% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.5833% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,13.1,29.1,9.8,"parathyroid gland: 29.1 nTPM (protected, limit 2); cerebellum: 13.1 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 2); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); hippocampal formation: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); amygdala: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182134,TDRKH,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.263099,-0.545099,-0.368613
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.9582% (minimum 95%, Missing); adrenal gland: 87.7551% (minimum 99%, Missing); amygdala: 78.7546% (minimum 99%, Missing); basal ganglia: 79.6296% (minimum 99%, Missing); bone marrow: 93.8865% (minimum 99%, Missing); cerebellum: 62.1387% (minimum 99%, Missing); cerebral cortex: 74.1379% (minimum 99%, Missing); choroid plexus: 88.4774% (minimum 99%, Missing); colon: 87.3984% (minimum 97%, Missing); duodenum: 90.7173% (minimum 99%, Missing); esophagus: 92.6724% (minimum 95%, Approved); heart muscle: 86.3454% (minimum 99%, Missing); hippocampal formation: 78.4672% (minimum 99%, Missing); hypothalamus: 74.9129% (minimum 99%, Missing); kidney: 84.6457% (minimum 99%, Missing); liver: 86.0000% (minimum 99%, Missing); lung: 83.6576% (minimum 99%, Missing); lymph node: 78.7546% (minimum 97%, Missing); midbrain: 76.5125% (minimum 99%, Missing); pancreas: 88.1148% (minimum 99%, Missing); parathyroid gland: 42.4901% (minimum 97%, Missing); pituitary gland: 82.6923% (minimum 99%, Missing); rectum: 84.6457% (minimum 97%, Missing); retina: 69.8052% (minimum 99%, Missing); salivary gland: 75.9717% (minimum 97%, Missing); skeletal muscle: 83.9844% (minimum 99%, Missing); skin: 90.7173% (minimum 95%, Missing); small intestine: 91.1017% (minimum 99%, Missing); smooth muscle: 88.8430% (minimum 99%, Missing); spinal cord: 76.5125% (minimum 99%, Missing); spleen: 77.8986% (minimum 95%, Missing); stomach: 88.4774% (minimum 97%, Missing); thymus: 68.6901% (minimum 95%, Missing); thyroid gland: 75.1748% (minimum 95%, Missing); tongue: 82.0611% (minimum 97%, Missing); urinary bladder: 89.5833% (minimum 97%, Missing)",0,3,partial,13.1,29.1,9.8,"parathyroid gland: 29.1 nTPM (protected, limit 2); cerebellum: 13.1 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 2); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); hippocampal formation: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 2); amygdala: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182134,TDRKH,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.263099,-0.545099,-0.368613
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182170,MRGPRG,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182170,MRGPRG,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182170,MRGPRG,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,7.3,12.7,5.8,"salivary gland: 12.7 nTPM (protected, limit 2); bone marrow: 7.3 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); esophagus: 3.6 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); spinal cord: 3.4 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182185,RAD51B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.3590% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 79.8165% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.0755% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.8571% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.3750% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.5484% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.5556% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.6522% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.7755% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.7317% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.4660% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.8571% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.2941% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.9912% (minimum 99%, Baseline (adaptation disabled)); liver: 80.5556% (minimum 99%, Baseline (adaptation disabled)); lung: 76.9912% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.9254% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.8165% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.5556% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.9254% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 81.3084% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.6786% (minimum 97%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 40.6542% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.8788% (minimum 99%, Baseline (adaptation disabled)); skin: 68.5039% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.3784% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.4419% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.9008% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.9912% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.6786% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.3784% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.8788% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.3115% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,7.3,12.7,5.8,"salivary gland: 12.7 nTPM (protected, limit 2); bone marrow: 7.3 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); esophagus: 3.6 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); spinal cord: 3.4 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182185,RAD51B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.35,-0.563458,-0.44625
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.3590% (minimum 95%, Missing); adrenal gland: 79.8165% (minimum 99%, Missing); amygdala: 82.0755% (minimum 99%, Missing); basal ganglia: 82.8571% (minimum 99%, Missing); bone marrow: 54.3750% (minimum 99%, Missing); cerebellum: 93.5484% (minimum 99%, Missing); cerebral cortex: 80.5556% (minimum 99%, Missing); choroid plexus: 75.6522% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 88.7755% (minimum 99%, Missing); esophagus: 70.7317% (minimum 97%, Missing); heart muscle: 84.4660% (minimum 99%, Missing); hippocampal formation: 82.8571% (minimum 99%, Missing); hypothalamus: 85.2941% (minimum 99%, Missing); kidney: 76.9912% (minimum 99%, Missing); liver: 80.5556% (minimum 99%, Missing); lung: 76.9912% (minimum 99%, Missing); lymph node: 64.9254% (minimum 97%, Missing); midbrain: 79.8165% (minimum 99%, Missing); pancreas: 80.5556% (minimum 99%, Missing); parathyroid gland: 64.9254% (minimum 97%, Missing); pituitary gland: 81.3084% (minimum 99%, Missing); rectum: 77.6786% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); salivary gland: 40.6542% (minimum 97%, Missing); skeletal muscle: 87.8788% (minimum 99%, Missing); skin: 68.5039% (minimum 95%, Missing); small intestine: 78.3784% (minimum 99%, Missing); smooth muscle: 67.4419% (minimum 99%, Missing); spinal cord: 71.9008% (minimum 99%, Missing); spleen: 76.9912% (minimum 95%, Missing); stomach: 77.6786% (minimum 97%, Missing); thymus: 60.0000% (minimum 95%, Missing); thyroid gland: 78.3784% (minimum 95%, Missing); tongue: 87.8788% (minimum 97%, Missing); urinary bladder: 71.3115% (minimum 97%, Missing)",0,7,partial,7.3,12.7,5.8,"salivary gland: 12.7 nTPM (protected, limit 2); bone marrow: 7.3 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); esophagus: 3.6 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); spinal cord: 3.4 nTPM (vital, limit 1); colon: 2.9 nTPM (protected, limit 2); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182185,RAD51B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.35,-0.563458,-0.44625
True,compatible,,True,True,False,,0,80,unavailable,0.7,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000182223,ZAR1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 87.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.7778% (minimum 99%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.5000% (minimum 97%, Baseline (adaptation disabled)); skin: 93.3333% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000182223,ZAR1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0166667,-0.095,-0.323333
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 77.7778% (minimum 99%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); salivary gland: 87.5000% (minimum 97%, Missing); skin: 93.3333% (minimum 95%, Missing)",0,80,unavailable,0.7,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000182223,ZAR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0166667,-0.095,-0.323333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,26.3,0.8,1.4,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000182256,GABRG3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.7447% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.7835% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.5385% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 87.3786% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.9474% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9011% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.8367% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.1707% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.7500% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9011% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.7500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.7742% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 75.6303% (minimum 99%, Baseline (adaptation disabled)); retina: 25.4958% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.8367% (minimum 97%, Baseline (adaptation disabled)); spinal cord: 97.8261% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.0000% (minimum 95%, Baseline (adaptation disabled)); thymus: 90.9091% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.5385% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,26.3,0.8,1.4,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000182256,GABRG3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0846154,-0.0516327,-0.735042
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.7447% (minimum 98%, Approved); amygdala: 92.7835% (minimum 99%, Missing); basal ganglia: 86.5385% (minimum 99%, Missing); cerebellum: 87.3786% (minimum 99%, Missing); cerebral cortex: 78.9474% (minimum 99%, Missing); choroid plexus: 98.9011% (minimum 99%, Missing); hippocampal formation: 91.8367% (minimum 99%, Missing); hypothalamus: 73.1707% (minimum 99%, Missing); kidney: 93.7500% (minimum 98%, Approved); lymph node: 93.7500% (minimum 97%, Missing); midbrain: 96.7742% (minimum 99%, Missing); pituitary gland: 75.6303% (minimum 99%, Missing); retina: 25.4958% (minimum 99%, Missing); salivary gland: 91.8367% (minimum 95%, Approved); spinal cord: 97.8261% (minimum 99%, Missing); spleen: 90.0000% (minimum 95%, Missing); thymus: 90.9091% (minimum 95%, Missing); thyroid gland: 86.5385% (minimum 95%, Missing)",0,3,partial,26.3,0.8,1.4,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000182256,GABRG3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0846154,-0.0325,-0.735042
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,0.2,0,4.8,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182261,NLRP10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 93.3333% (minimum 99%, Baseline (adaptation disabled)); retina: 87.5000% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 22.5806% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,0.2,0,4.8,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182261,NLRP10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.724194,0.03,-0.115
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 93.3333% (minimum 99%, Missing); retina: 87.5000% (minimum 99%, Missing); skeletal muscle: 93.3333% (minimum 99%, Missing); skin: 22.5806% (minimum 95%, Missing)",0,2,partial,0.2,0,4.8,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182261,NLRP10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.724194,0.03,-0.115
True,compatible,,True,True,False,,0,1,partial,1.5,0.9,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000182264,IZUMO1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 98.9247% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.3545% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.9247% (minimum 99%, Baseline (adaptation disabled)); lung: 96.3351% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.4623% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.3368% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,1.5,0.9,0.3,"pancreas: 1.5 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000182264,IZUMO1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0339572,-0.0166321,-0.0653769
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 92.4623% (minimum 95%, Enhanced)",0,1,partial,1.5,0.9,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000182264,IZUMO1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.0253769
True,compatible,,True,True,False,,0,2,partial,1.1,0.2,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000182308,DCAF4L1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.7654% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.9592% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.9592% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.3607% (minimum 99%, Baseline (adaptation disabled)); liver: 98.3607% (minimum 99%, Baseline (adaptation disabled)); lung: 98.7654% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1660% (minimum 99%, Baseline (adaptation disabled)); retina: 97.1660% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.6175% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,1.1,0.2,0.6,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000182308,DCAF4L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0256098,0.0217355,-0.0338247
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.7654% (minimum 99%, Missing); pituitary gland: 97.1660% (minimum 99%, Missing); retina: 97.1660% (minimum 99%, Missing)",0,2,partial,1.1,0.2,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000182308,DCAF4L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.0183401
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000182315,MBD3L3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 88.8889% (minimum 99%, Baseline (adaptation disabled)); duodenum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); thymus: 88.8889% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000182315,MBD3L3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.0611111,0.03,-0.101111
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 88.8889% (minimum 99%, Missing); duodenum: 88.8889% (minimum 99%, Missing); thymus: 88.8889% (minimum 95%, Missing)",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000182315,MBD3L3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.0611111,0.03,-0.101111
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,56.9,1.2,2.1,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182324,KCNJ14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9048% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.2500% (minimum 99%, Baseline (adaptation disabled)); amygdala: 56.5217% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 22.4138% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 39.3939% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 43.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.2500% (minimum 99%, Baseline (adaptation disabled)); colon: 72.2222% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.4706% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 54.1667% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.9048% (minimum 99%, Baseline (adaptation disabled)); liver: 59.0909% (minimum 99%, Baseline (adaptation disabled)); lung: 65.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.4706% (minimum 97%, Baseline (adaptation disabled)); midbrain: 52.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.4211% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.0909% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.2500% (minimum 97%, Baseline (adaptation disabled)); retina: 2.2337% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.4211% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 44.8276% (minimum 99%, Baseline (adaptation disabled)); skin: 38.2353% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.2222% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.2500% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.4211% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.4211% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.2222% (minimum 97%, Baseline (adaptation disabled)); thymus: 81.2500% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.4211% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,56.9,1.2,2.1,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182324,KCNJ14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.567647,-0.45,-0.967663
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9048% (minimum 95%, Missing); adrenal gland: 81.2500% (minimum 99%, Missing); amygdala: 56.5217% (minimum 99%, Missing); basal ganglia: 22.4138% (minimum 99%, Missing); bone marrow: 39.3939% (minimum 99%, Missing); cerebellum: 43.3333% (minimum 99%, Missing); cerebral cortex: 43.3333% (minimum 99%, Missing); choroid plexus: 81.2500% (minimum 99%, Missing); colon: 72.2222% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); esophagus: 52.0000% (minimum 97%, Missing); heart muscle: 76.4706% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 54.1667% (minimum 99%, Missing); kidney: 61.9048% (minimum 99%, Missing); liver: 59.0909% (minimum 99%, Missing); lung: 65.0000% (minimum 99%, Missing); lymph node: 76.4706% (minimum 97%, Missing); midbrain: 52.0000% (minimum 99%, Missing); pancreas: 68.4211% (minimum 99%, Missing); parathyroid gland: 86.6667% (minimum 97%, Missing); pituitary gland: 59.0909% (minimum 99%, Missing); rectum: 81.2500% (minimum 97%, Missing); retina: 2.2337% (minimum 99%, Missing); salivary gland: 68.4211% (minimum 97%, Missing); skeletal muscle: 44.8276% (minimum 99%, Missing); skin: 38.2353% (minimum 95%, Missing); small intestine: 72.2222% (minimum 99%, Missing); smooth muscle: 81.2500% (minimum 99%, Missing); spinal cord: 68.4211% (minimum 99%, Missing); spleen: 68.4211% (minimum 95%, Missing); stomach: 72.2222% (minimum 97%, Missing); thymus: 81.2500% (minimum 95%, Missing); thyroid gland: 52.0000% (minimum 95%, Missing); tongue: 86.6667% (minimum 97%, Missing); urinary bladder: 68.4211% (minimum 97%, Missing)",0,80,unavailable,56.9,1.2,2.1,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182324,KCNJ14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.567647,-0.45,-0.967663
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.1,2,1.5,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182405,PGBD4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.9630% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.6364% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.7143% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 45.9459% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 65.3846% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.7143% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.8333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.8387% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.3846% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.9630% (minimum 99%, Baseline (adaptation disabled)); liver: 56.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 70.8333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 45.9459% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.9630% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.3846% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 53.1250% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.9130% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.7143% (minimum 97%, Baseline (adaptation disabled)); retina: 42.5000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.8333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 25.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 53.1250% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.9130% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.9630% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.8387% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.8387% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.9630% (minimum 95%, Baseline (adaptation disabled)); tongue: 58.6207% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.2727% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.1,2,1.5,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182405,PGBD4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.41875,-0.510541,-0.74
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.0000% (minimum 95%, Missing); adrenal gland: 68.0000% (minimum 99%, Missing); amygdala: 68.0000% (minimum 99%, Missing); basal ganglia: 62.9630% (minimum 99%, Missing); bone marrow: 38.6364% (minimum 99%, Missing); cerebellum: 60.7143% (minimum 99%, Missing); cerebral cortex: 45.9459% (minimum 99%, Missing); choroid plexus: 68.0000% (minimum 99%, Missing); colon: 65.3846% (minimum 97%, Missing); duodenum: 60.7143% (minimum 99%, Missing); esophagus: 70.8333% (minimum 97%, Missing); heart muscle: 54.8387% (minimum 99%, Missing); hippocampal formation: 65.3846% (minimum 99%, Missing); hypothalamus: 60.7143% (minimum 99%, Missing); kidney: 62.9630% (minimum 99%, Missing); liver: 56.6667% (minimum 99%, Missing); lung: 70.8333% (minimum 99%, Missing); lymph node: 45.9459% (minimum 97%, Missing); midbrain: 62.9630% (minimum 99%, Missing); pancreas: 65.3846% (minimum 99%, Missing); parathyroid gland: 53.1250% (minimum 97%, Missing); pituitary gland: 73.9130% (minimum 99%, Missing); rectum: 60.7143% (minimum 97%, Missing); retina: 42.5000% (minimum 99%, Missing); salivary gland: 70.8333% (minimum 97%, Missing); skeletal muscle: 25.0000% (minimum 99%, Missing); skin: 53.1250% (minimum 95%, Missing); small intestine: 60.7143% (minimum 99%, Missing); smooth muscle: 73.9130% (minimum 99%, Missing); spinal cord: 62.9630% (minimum 99%, Missing); spleen: 54.8387% (minimum 95%, Missing); stomach: 54.8387% (minimum 97%, Missing); thymus: 56.6667% (minimum 95%, Missing); thyroid gland: 62.9630% (minimum 95%, Missing); tongue: 58.6207% (minimum 97%, Missing); urinary bladder: 77.2727% (minimum 97%, Missing)",0,80,unavailable,5.1,2,1.5,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182405,PGBD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.41875,-0.510541,-0.74
True,compatible,,True,True,False,,0,2,partial,0,0,0.1,,,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000182459,TEX19,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0.1,,,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000182459,TEX19,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0466777,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0.1,,,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000182459,TEX19,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0466777,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,11,partial,98,70.4,92.3,"bone marrow: 98 nTPM (vital, limit 1); thymus: 92.3 nTPM (manageable, limit 5); lymph node: 70.4 nTPM (protected, limit 2); esophagus: 40.2 nTPM (protected, limit 2); urinary bladder: 37.2 nTPM (protected, limit 2); rectum: 34.7 nTPM (protected, limit 2); smooth muscle: 33.3 nTPM (vital, limit 6); colon: 29.7 nTPM (protected, limit 2); spleen: 27.6 nTPM (manageable, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); skin: 20.5 nTPM (manageable, limit 5); hippocampal formation: 20 nTPM (vital, limit 1); stomach: 18.5 nTPM (protected, limit 2); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); salivary gland: 15 nTPM (protected, limit 2); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 2); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182481,KPNA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 89.0447% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.9552% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.9457% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.0403% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 67.4635% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.1756% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.5017% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.4887% (minimum 99%, Baseline (adaptation disabled)); colon: 87.2477% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.4840% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.7923% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.0394% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.8320% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.8278% (minimum 99%, Baseline (adaptation disabled)); liver: 90.0709% (minimum 99%, Baseline (adaptation disabled)); lung: 92.1542% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.2690% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.5319% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.4439% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.1756% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.0403% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.4140% (minimum 97%, Baseline (adaptation disabled)); retina: 90.4317% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.1256% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.4253% (minimum 99%, Baseline (adaptation disabled)); skin: 90.8359% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.9513% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.9197% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.8702% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.0416% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.6554% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.7648% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.6585% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.5258% (minimum 97%, Baseline (adaptation disabled))",0,11,partial,98,70.4,92.3,"bone marrow: 98 nTPM (vital, limit 1); thymus: 92.3 nTPM (manageable, limit 5); lymph node: 70.4 nTPM (protected, limit 2); esophagus: 40.2 nTPM (protected, limit 2); urinary bladder: 37.2 nTPM (protected, limit 2); rectum: 34.7 nTPM (protected, limit 2); smooth muscle: 33.3 nTPM (vital, limit 1); colon: 29.7 nTPM (protected, limit 2); spleen: 27.6 nTPM (manageable, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); adipose tissue: 25 nTPM (manageable, limit 5); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); skin: 20.5 nTPM (manageable, limit 5); hippocampal formation: 20 nTPM (vital, limit 1); stomach: 18.5 nTPM (protected, limit 2); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); salivary gland: 15 nTPM (protected, limit 2); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 2); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182481,KPNA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.262352,-0.22731,-0.315365
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 92.9552% (minimum 99%, Missing); amygdala: 91.9457% (minimum 99%, Missing); basal ganglia: 93.0403% (minimum 99%, Missing); bone marrow: 67.4635% (minimum 99%, Missing); cerebellum: 95.1756% (minimum 99%, Missing); cerebral cortex: 88.5017% (minimum 99%, Missing); choroid plexus: 95.4887% (minimum 99%, Missing); colon: 87.2477% (minimum 97%, Missing); duodenum: 88.8889% (minimum 99%, Missing); esophagus: 83.4840% (minimum 97%, Missing); heart muscle: 89.7923% (minimum 99%, Missing); hippocampal formation: 91.0394% (minimum 99%, Missing); hypothalamus: 89.8320% (minimum 99%, Missing); kidney: 92.8278% (minimum 99%, Missing); liver: 90.0709% (minimum 99%, Missing); lung: 92.1542% (minimum 99%, Missing); lymph node: 74.2690% (minimum 97%, Missing); midbrain: 92.5319% (minimum 99%, Missing); pancreas: 95.4439% (minimum 99%, Missing); parathyroid gland: 95.1756% (minimum 97%, Missing); pituitary gland: 93.0403% (minimum 99%, Missing); rectum: 85.4140% (minimum 97%, Missing); retina: 90.4317% (minimum 99%, Missing); salivary gland: 93.1256% (minimum 97%, Missing); skeletal muscle: 93.4253% (minimum 99%, Missing); skin: 90.8359% (minimum 95%, Missing); small intestine: 89.9513% (minimum 99%, Missing); smooth muscle: 85.9197% (minimum 95%, Enhanced); spinal cord: 92.8702% (minimum 99%, Missing); spleen: 88.0416% (minimum 95%, Missing); stomach: 91.6554% (minimum 97%, Missing); thymus: 68.7648% (minimum 95%, Missing); tongue: 92.6585% (minimum 97%, Missing); urinary bladder: 84.5258% (minimum 97%, Missing)",0,11,partial,98,70.4,92.3,"bone marrow: 98 nTPM (vital, limit 1); thymus: 92.3 nTPM (manageable, limit 5); lymph node: 70.4 nTPM (protected, limit 2); esophagus: 40.2 nTPM (protected, limit 2); urinary bladder: 37.2 nTPM (protected, limit 2); rectum: 34.7 nTPM (protected, limit 2); smooth muscle: 33.3 nTPM (vital, limit 6); colon: 29.7 nTPM (protected, limit 2); spleen: 27.6 nTPM (manageable, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); skin: 20.5 nTPM (manageable, limit 5); hippocampal formation: 20 nTPM (vital, limit 1); stomach: 18.5 nTPM (protected, limit 2); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 2); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); salivary gland: 15 nTPM (protected, limit 2); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 2); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182481,KPNA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.262352,-0.22731,-0.315365
True,compatible,,True,True,False,,0,7,partial,0.4,0.1,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000182583,VCX,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.7842% (minimum 99%, Baseline (adaptation disabled))",0,7,partial,0.4,0.1,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000182583,VCX,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0469325,0.0269325,-0.00215805
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.7842% (minimum 99%, Missing)",0,7,partial,0.4,0.1,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,ENSG00000182583,VCX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,-0.00215805
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin; spleen,ENSG00000182613,OR2V2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 33.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 66.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin; spleen,ENSG00000182613,OR2V2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,0.03,-0.656667
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 66.6667% (minimum 95%, Missing); bone marrow: 33.3333% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); retina: 66.6667% (minimum 99%, Missing); skin: 66.6667% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing)",0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin; spleen,ENSG00000182613,OR2V2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,0.03,-0.656667
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3,0.1,0,"retina: 3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000182645,CCDC172,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.3471% (minimum 99%, Baseline (adaptation disabled)); retina: 79.8658% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3,0.1,0,"retina: 3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000182645,CCDC172,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.0216667,-0.191342
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 98.3471% (minimum 99%, Missing); retina: 79.8658% (minimum 99%, Missing)",0,80,unavailable,3,0.1,0,"retina: 3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000182645,CCDC172,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.0216667,-0.191342
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182652,OR4Q3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182652,OR4Q3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182652,OR4Q3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,4,8.8,3.9,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182752,PAPPA,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7226% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.0392% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.5915% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.6851% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.5517% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.9796% (minimum 99%, Baseline (adaptation disabled)); lung: 97.4930% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.8701% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.8325% (minimum 97%, Baseline (adaptation disabled)); retina: 98.5915% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.7306% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.5946% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 94.0860% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,4,8.8,3.9,"parathyroid gland: 8.8 nTPM (protected, limit 2); urinary bladder: 4.4 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182752,PAPPA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,-0.00277402,-0.0816751,-0.0440541
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.5915% (minimum 99%, Missing); kidney: 94.9796% (minimum 95%, Enhanced); retina: 98.5915% (minimum 99%, Missing); smooth muscle: 94.5946% (minimum 95%, Enhanced)",0,2,partial,4,8.8,3.9,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182752,PAPPA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,0.0387006,0.0117672,-0.00408451
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.4,1.1,0.8,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,ENSG00000182791,CCDC87,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5294% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5294% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.8102% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.5294% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5294% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5294% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5294% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.8102% (minimum 99%, Baseline (adaptation disabled)); liver: 98.5294% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.4138% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.1014% (minimum 99%, Baseline (adaptation disabled)); retina: 90.5405% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5294% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 94.3662% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.4,1.1,0.8,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,ENSG00000182791,CCDC87,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,-0.00633803,-0.0458621,-0.0845946
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5294% (minimum 99%, Missing); basal ganglia: 98.5294% (minimum 99%, Missing); cerebral cortex: 97.8102% (minimum 99%, Missing); choroid plexus: 98.5294% (minimum 99%, Missing); heart muscle: 98.5294% (minimum 99%, Missing); hippocampal formation: 98.5294% (minimum 99%, Missing); hypothalamus: 98.5294% (minimum 99%, Missing); kidney: 97.8102% (minimum 99%, Missing); liver: 98.5294% (minimum 99%, Missing); parathyroid gland: 92.4138% (minimum 97%, Missing); pituitary gland: 97.1014% (minimum 99%, Missing); retina: 90.5405% (minimum 99%, Missing); smooth muscle: 98.5294% (minimum 99%, Missing); thyroid gland: 94.3662% (minimum 95%, Missing)",0,80,unavailable,1.4,1.1,0.8,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,ENSG00000182791,CCDC87,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,-0.00633803,-0.0458621,-0.0845946
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182793,GSTA5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182793,GSTA5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182793,GSTA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1.9,0.4,0.1,"pancreas: 1.9 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000182798,MAGEB17,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 94.1176% (minimum 95%, Baseline (adaptation disabled)); choroid plexus: 94.1176% (minimum 99%, Baseline (adaptation disabled)); colon: 88.8889% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); pancreas: 45.7143% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); stomach: 80.0000% (minimum 97%, Baseline (adaptation disabled)); tongue: 88.8889% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.9,0.4,0.1,"pancreas: 1.9 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000182798,MAGEB17,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.00882353,-0.17,-0.532857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 94.1176% (minimum 95%, Missing); choroid plexus: 94.1176% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); heart muscle: 94.1176% (minimum 99%, Missing); pancreas: 45.7143% (minimum 99%, Missing); skeletal muscle: 88.8889% (minimum 99%, Missing); smooth muscle: 94.1176% (minimum 99%, Missing); stomach: 80.0000% (minimum 97%, Missing); tongue: 88.8889% (minimum 97%, Missing)",0,80,unavailable,1.9,0.4,0.1,"pancreas: 1.9 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000182798,MAGEB17,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.00882353,-0.17,-0.532857
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,3.8,0.6,1.6,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182890,GLUD2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.3614% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.8204% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.3614% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.2857% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0392% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.8204% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.7742% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.9367% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.1677% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.5926% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.3614% (minimum 99%, Baseline (adaptation disabled)); liver: 79.7872% (minimum 99%, Baseline (adaptation disabled)); lung: 96.7742% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.4634% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.7500% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.7742% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.4026% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.1538% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.7742% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.4026% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.3396% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.1538% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,3.8,0.6,1.6,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182890,GLUD2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0463855,-0.00846154,-0.192128
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.3614% (minimum 95%, Missing); adrenal gland: 89.8204% (minimum 99%, Missing); amygdala: 90.3614% (minimum 99%, Missing); basal ganglia: 89.2857% (minimum 99%, Missing); cerebellum: 98.0392% (minimum 99%, Missing); cerebral cortex: 89.8204% (minimum 99%, Missing); choroid plexus: 90.9091% (minimum 99%, Missing); esophagus: 96.7742% (minimum 97%, Missing); heart muscle: 94.9367% (minimum 99%, Missing); hippocampal formation: 93.1677% (minimum 99%, Missing); hypothalamus: 92.5926% (minimum 99%, Missing); kidney: 90.3614% (minimum 99%, Missing); liver: 79.7872% (minimum 99%, Missing); lung: 96.7742% (minimum 99%, Missing); midbrain: 91.4634% (minimum 99%, Missing); pancreas: 93.7500% (minimum 99%, Missing); parathyroid gland: 96.7742% (minimum 97%, Missing); pituitary gland: 97.4026% (minimum 99%, Missing); salivary gland: 96.1538% (minimum 97%, Missing); skeletal muscle: 96.7742% (minimum 99%, Missing); small intestine: 97.4026% (minimum 99%, Missing); spinal cord: 94.3396% (minimum 99%, Missing); stomach: 96.1538% (minimum 97%, Missing)",0,1,partial,3.8,0.6,1.6,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000182890,GLUD2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0463855,-0.00846154,-0.192128
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182896,TMEM95,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182896,TMEM95,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182896,TMEM95,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,1,partial,0,0,0.7,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000182898,TCHHL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"skin: 12.5000% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,0,0,0.7,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000182898,TCHHL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.825,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"skin: 12.5000% (minimum 60%, Enhanced)",0,1,partial,0,0,0.7,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000182898,TCHHL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.475,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,43.6,0.9,0.2,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000182901,RGS7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 43.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 17.9724% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 9.4891% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 8.4416% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 8.2105% (minimum 99%, Baseline (adaptation disabled)); colon: 95.1220% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 14.7727% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 19.6970% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.2500% (minimum 99%, Baseline (adaptation disabled)); liver: 92.8571% (minimum 99%, Baseline (adaptation disabled)); midbrain: 29.5455% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.8571% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 58.2090% (minimum 99%, Baseline (adaptation disabled)); retina: 48.7500% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 42.3913% (minimum 99%, Baseline (adaptation disabled)); stomach: 81.2500% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,43.6,0.9,0.2,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000182901,RGS7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.00121951,-0.1575,-0.907895
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 43.3333% (minimum 95%, Enhanced); amygdala: 17.9724% (minimum 99%, Missing); basal ganglia: 9.4891% (minimum 99%, Missing); cerebellum: 8.4416% (minimum 99%, Missing); cerebral cortex: 8.2105% (minimum 99%, Missing); hippocampal formation: 14.7727% (minimum 99%, Missing); hypothalamus: 19.6970% (minimum 99%, Missing); kidney: 81.2500% (minimum 95%, Enhanced); liver: 92.8571% (minimum 95%, Enhanced); midbrain: 29.5455% (minimum 99%, Missing); pancreas: 92.8571% (minimum 95%, Enhanced); pituitary gland: 58.2090% (minimum 99%, Missing); retina: 48.7500% (minimum 99%, Missing); spinal cord: 42.3913% (minimum 99%, Missing)",0,5,partial,43.6,0.9,0.2,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000182901,RGS7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,0.0125,-0.907895
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,1.7,1.7,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182950,CIMAP1C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.9914% (minimum 95%, Baseline (adaptation disabled)); amygdala: 98.6486% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.6486% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6486% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6486% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.3065% (minimum 99%, Baseline (adaptation disabled)); colon: 94.3966% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.2063% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.2174% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.6332% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.7679% (minimum 99%, Baseline (adaptation disabled)); liver: 95.2174% (minimum 99%, Baseline (adaptation disabled)); lung: 93.1915% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2063% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.6332% (minimum 99%, Baseline (adaptation disabled)); skin: 92.7966% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.4758% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.4758% (minimum 99%, Baseline (adaptation disabled)); stomach: 92.7966% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 93.9914% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.0526% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,1.7,1.7,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182950,CIMAP1C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0220339,-0.0420339,-0.106935
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.9914% (minimum 95%, Missing); amygdala: 98.6486% (minimum 99%, Missing); basal ganglia: 98.6486% (minimum 99%, Missing); bone marrow: 98.6486% (minimum 99%, Missing); cerebral cortex: 98.6486% (minimum 99%, Missing); choroid plexus: 88.3065% (minimum 99%, Missing); colon: 94.3966% (minimum 97%, Missing); duodenum: 98.2063% (minimum 99%, Missing); esophagus: 95.2174% (minimum 97%, Missing); heart muscle: 95.6332% (minimum 99%, Missing); hypothalamus: 97.7679% (minimum 99%, Missing); liver: 95.2174% (minimum 99%, Missing); lung: 93.1915% (minimum 99%, Missing); pancreas: 98.2063% (minimum 99%, Missing); pituitary gland: 95.6332% (minimum 99%, Missing); skin: 92.7966% (minimum 95%, Missing); small intestine: 96.4758% (minimum 99%, Missing); smooth muscle: 96.4758% (minimum 99%, Missing); stomach: 92.7966% (minimum 97%, Missing); thyroid gland: 93.9914% (minimum 95%, Missing); urinary bladder: 96.0526% (minimum 97%, Missing)",0,80,unavailable,2.9,1.7,1.7,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182950,CIMAP1C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0220339,-0.0420339,-0.106935
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,5.4,0.1,0.1,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000182968,SOX1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 16.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 17.0213% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 30.7692% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 19.0476% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 88.8889% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 25.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 12.9032% (minimum 99%, Baseline (adaptation disabled)); midbrain: 28.5714% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); skin: 88.8889% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 57.1429% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,5.4,0.1,0.1,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000182968,SOX1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0611111,-0.0811111,-0.860968
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 16.6667% (minimum 99%, Missing); basal ganglia: 17.0213% (minimum 99%, Missing); cerebellum: 30.7692% (minimum 99%, Missing); cerebral cortex: 19.0476% (minimum 99%, Missing); choroid plexus: 80.0000% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); hippocampal formation: 25.0000% (minimum 99%, Missing); hypothalamus: 12.9032% (minimum 99%, Missing); midbrain: 28.5714% (minimum 99%, Missing); pituitary gland: 88.8889% (minimum 99%, Missing); skin: 88.8889% (minimum 95%, Missing); spinal cord: 57.1429% (minimum 99%, Missing)",0,80,unavailable,5.4,0.1,0.1,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000182968,SOX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0611111,-0.0811111,-0.860968
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182974,OR4M2B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182974,OR4M2B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000182974,OR4M2B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.2,1.8,3.2,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182993,C12orf60,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7020% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.6614% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.7020% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.7020% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.6216% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.9732% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8199% (minimum 99%, Baseline (adaptation disabled)); colon: 96.6216% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.7143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.7020% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.0789% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.1190% (minimum 99%, Baseline (adaptation disabled)); liver: 71.1443% (minimum 99%, Baseline (adaptation disabled)); lung: 94.0789% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8199% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.4641% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.0789% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.8571% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.9732% (minimum 99%, Baseline (adaptation disabled)); retina: 69.7561% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.7020% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.6216% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6207% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.7143% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.7020% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 91.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.7020% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.2,1.8,3.2,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182993,C12orf60,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.132857,-0.0818012,-0.292439
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7020% (minimum 95%, Missing); adrenal gland: 75.6614% (minimum 99%, Missing); amygdala: 95.3333% (minimum 99%, Missing); basal ganglia: 94.7020% (minimum 99%, Missing); bone marrow: 94.7020% (minimum 99%, Missing); cerebellum: 96.6216% (minimum 99%, Missing); cerebral cortex: 95.9732% (minimum 99%, Missing); choroid plexus: 88.8199% (minimum 99%, Missing); colon: 96.6216% (minimum 97%, Missing); heart muscle: 81.7143% (minimum 99%, Missing); hippocampal formation: 94.7020% (minimum 99%, Missing); hypothalamus: 94.0789% (minimum 99%, Missing); kidney: 85.1190% (minimum 99%, Missing); liver: 71.1443% (minimum 99%, Missing); lung: 94.0789% (minimum 99%, Missing); lymph node: 88.8199% (minimum 97%, Missing); midbrain: 93.4641% (minimum 99%, Missing); pancreas: 94.0789% (minimum 99%, Missing); parathyroid gland: 92.8571% (minimum 97%, Missing); pituitary gland: 95.9732% (minimum 99%, Missing); retina: 69.7561% (minimum 99%, Missing); salivary gland: 94.7020% (minimum 97%, Missing); skeletal muscle: 91.6667% (minimum 99%, Missing); small intestine: 96.6216% (minimum 99%, Missing); smooth muscle: 98.6207% (minimum 99%, Missing); spinal cord: 91.6667% (minimum 99%, Missing); spleen: 81.7143% (minimum 95%, Missing); stomach: 94.7020% (minimum 97%, Missing); thyroid gland: 91.6667% (minimum 95%, Missing); tongue: 94.7020% (minimum 97%, Missing)",0,80,unavailable,6.2,1.8,3.2,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000182993,C12orf60,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.132857,-0.0818012,-0.292439
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183024,OR1G1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183024,OR1G1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183024,OR1G1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.3,19.4,0.2,"colon: 19.4 nTPM (protected, limit 2); rectum: 10.3 nTPM (protected, limit 2); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000183034,OTOP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 17.4468% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.1818% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.0000% (minimum 97%, Baseline (adaptation disabled)); rectum: 28.4722% (minimum 97%, Baseline (adaptation disabled)); small intestine: 75.9259% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.1818% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.3,19.4,0.2,"colon: 19.4 nTPM (protected, limit 2); rectum: 10.3 nTPM (protected, limit 2); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000183034,OTOP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.00348837,-0.795532,-0.230741
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 17.4468% (minimum 97%, Missing); duodenum: 93.1818% (minimum 99%, Missing); esophagus: 82.0000% (minimum 97%, Missing); rectum: 28.4722% (minimum 97%, Missing); small intestine: 75.9259% (minimum 99%, Missing); smooth muscle: 93.1818% (minimum 99%, Missing)",0,80,unavailable,1.3,19.4,0.2,"colon: 19.4 nTPM (protected, limit 2); rectum: 10.3 nTPM (protected, limit 2); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000183034,OTOP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.00348837,-0.795532,-0.230741
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000183035,CYLC1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000183035,CYLC1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000183035,CYLC1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,3,partial,0.7,0.5,0.6,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183066,WBP2NL,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 96.6480% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.1111% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.1910% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.6480% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.7401% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.2955% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2955% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8571% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.7401% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.1111% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.2955% (minimum 99%, Baseline (adaptation disabled)); retina: 96.6480% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.1111% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.7,0.5,0.6,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183066,WBP2NL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0164804,0.00191011,-0.0288889
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 96.6480% (minimum 99%, Missing); basal ganglia: 96.1111% (minimum 99%, Missing); choroid plexus: 98.8571% (minimum 99%, Missing); hippocampal formation: 97.7401% (minimum 99%, Missing); hypothalamus: 98.2955% (minimum 99%, Missing); midbrain: 97.7401% (minimum 99%, Missing); pituitary gland: 98.2955% (minimum 99%, Missing); retina: 96.6480% (minimum 99%, Missing); spinal cord: 96.1111% (minimum 99%, Missing)",0,3,partial,0.7,0.5,0.6,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183066,WBP2NL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0442529,0.0242529,-0.0288889
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,11.2,16.3,14,"parathyroid gland: 16.3 nTPM (protected, limit 2); thymus: 14 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 2); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); lymph node: 8.6 nTPM (protected, limit 2); thyroid gland: 8.4 nTPM (manageable, limit 5); duodenum: 8.4 nTPM (vital, limit 1); spinal cord: 8.4 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 2); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); cerebral cortex: 6.9 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); esophagus: 6 nTPM (protected, limit 2); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000183137,CEP57L1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.2676% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 77.6074% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.6797% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.6154% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 71.6714% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.6438% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.3151% (minimum 99%, Baseline (adaptation disabled)); colon: 75.5224% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0742% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.8307% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.3700% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.6797% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.0532% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 72.2857% (minimum 99%, Baseline (adaptation disabled)); lung: 79.8107% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.6313% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.0897% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.0864% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.8173% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.4104% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.6704% (minimum 97%, Baseline (adaptation disabled)); retina: 70.0831% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.2237% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.3505% (minimum 99%, Baseline (adaptation disabled)); skin: 79.5597% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.8997% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.8683% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.0742% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.1341% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.0864% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.3766% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.0742% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.0633% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.3175% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,11.2,16.3,14,"parathyroid gland: 16.3 nTPM (protected, limit 2); thymus: 14 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 2); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); lymph node: 8.6 nTPM (protected, limit 2); thyroid gland: 8.4 nTPM (manageable, limit 5); duodenum: 8.4 nTPM (vital, limit 1); spinal cord: 8.4 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 2); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); cerebral cortex: 6.9 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); esophagus: 6 nTPM (protected, limit 2); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000183137,CEP57L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.306234,-0.361827,-0.296849
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.2676% (minimum 95%, Missing); adrenal gland: 77.6074% (minimum 99%, Missing); amygdala: 82.6797% (minimum 99%, Missing); basal ganglia: 84.6154% (minimum 99%, Missing); bone marrow: 71.6714% (minimum 99%, Missing); cerebellum: 86.6438% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 99%, Missing); choroid plexus: 69.3151% (minimum 99%, Missing); colon: 75.5224% (minimum 97%, Missing); duodenum: 75.0742% (minimum 99%, Missing); esophagus: 80.8307% (minimum 97%, Missing); heart muscle: 77.3700% (minimum 99%, Missing); hippocampal formation: 82.6797% (minimum 99%, Missing); hypothalamus: 84.0532% (minimum 99%, Missing); kidney: 76.6667% (minimum 99%, Missing); liver: 72.2857% (minimum 99%, Missing); lung: 79.8107% (minimum 99%, Missing); lymph node: 74.6313% (minimum 97%, Missing); midbrain: 81.0897% (minimum 99%, Missing); pancreas: 78.0864% (minimum 99%, Missing); parathyroid gland: 60.8173% (minimum 97%, Missing); pituitary gland: 82.4104% (minimum 99%, Missing); rectum: 70.6704% (minimum 97%, Missing); retina: 70.0831% (minimum 99%, Missing); salivary gland: 83.2237% (minimum 97%, Missing); skeletal muscle: 81.3505% (minimum 99%, Missing); skin: 79.5597% (minimum 95%, Missing); small intestine: 76.8997% (minimum 99%, Missing); smooth muscle: 70.8683% (minimum 99%, Missing); spinal cord: 75.0742% (minimum 99%, Missing); spleen: 77.1341% (minimum 95%, Missing); stomach: 78.0864% (minimum 97%, Missing); thymus: 64.3766% (minimum 95%, Missing); thyroid gland: 75.0742% (minimum 95%, Missing); tongue: 80.0633% (minimum 97%, Missing); urinary bladder: 80.3175% (minimum 97%, Missing)",0,3,partial,11.2,16.3,14,"parathyroid gland: 16.3 nTPM (protected, limit 2); thymus: 14 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 2); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); lymph node: 8.6 nTPM (protected, limit 2); thyroid gland: 8.4 nTPM (manageable, limit 5); duodenum: 8.4 nTPM (vital, limit 1); spinal cord: 8.4 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 2); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 2); cerebral cortex: 6.9 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); esophagus: 6 nTPM (protected, limit 2); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 2); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000183137,CEP57L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.306234,-0.361827,-0.296849
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,56.6,0.1,24.1,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus,ENSG00000183166,CALN1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 22.1429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 26.9565% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 14.7619% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.7838% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 5.1926% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 10.5085% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.4872% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 20.9459% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 28.4404% (minimum 99%, Baseline (adaptation disabled)); liver: 93.9394% (minimum 99%, Baseline (adaptation disabled)); midbrain: 21.6783% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.5000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 86.1111% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.8750% (minimum 97%, Baseline (adaptation disabled)); retina: 63.2653% (minimum 99%, Baseline (adaptation disabled)); skin: 48.4375% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 15.1961% (minimum 99%, Baseline (adaptation disabled)); thymus: 11.3971% (minimum 95%, Baseline (adaptation disabled))",0,3,partial,56.6,0.1,24.1,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus,ENSG00000183166,CALN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.836029,-0.00125,-0.938074
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 22.1429% (minimum 99%, Missing); amygdala: 26.9565% (minimum 99%, Missing); basal ganglia: 14.7619% (minimum 99%, Missing); bone marrow: 83.7838% (minimum 99%, Missing); cerebellum: 5.1926% (minimum 99%, Missing); cerebral cortex: 10.5085% (minimum 99%, Missing); choroid plexus: 79.4872% (minimum 99%, Missing); hippocampal formation: 20.9459% (minimum 99%, Missing); hypothalamus: 28.4404% (minimum 99%, Missing); liver: 93.9394% (minimum 98%, Approved); midbrain: 21.6783% (minimum 99%, Missing); pancreas: 77.5000% (minimum 99%, Missing); pituitary gland: 86.1111% (minimum 99%, Missing); rectum: 96.8750% (minimum 97%, Missing); retina: 63.2653% (minimum 99%, Missing); skin: 48.4375% (minimum 95%, Missing); spinal cord: 15.1961% (minimum 99%, Missing); thymus: 11.3971% (minimum 95%, Missing)",0,3,partial,56.6,0.1,24.1,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus,ENSG00000183166,CALN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.836029,-0.00125,-0.938074
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,8.5,0,0,"retina: 8.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000183185,GABRR3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"retina: 1.1628% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,8.5,0,0,"retina: 8.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000183185,GABRR3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.978372
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"retina: 1.1628% (minimum 99%, Missing)",0,80,unavailable,8.5,0,0,"retina: 8.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000183185,GABRR3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.978372
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183206,POTEC,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183206,POTEC,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183206,POTEC,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,7,partial,0,0,0.2,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,ENSG00000183246,RIMBP3C,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,7,partial,0,0,0.2,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,ENSG00000183246,RIMBP3C,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0115385,0.03,0.01
True,compatible,,True,True,True,,0,7,partial,0,0,0.2,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,ENSG00000183246,RIMBP3C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0115385,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183269,OR52E8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183269,OR52E8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183269,OR52E8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000183304,FAM9A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.6744% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.6744% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.4545% (minimum 99%, Baseline (adaptation disabled)); liver: 93.3333% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.6744% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.6744% (minimum 99%, Baseline (adaptation disabled)); retina: 84.0000% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.6744% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.6744% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.6744% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000183304,FAM9A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0267442,0.00674419,-0.15
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.6744% (minimum 99%, Missing); cerebral cortex: 97.6744% (minimum 99%, Missing); heart muscle: 95.4545% (minimum 99%, Missing); liver: 93.3333% (minimum 99%, Missing); midbrain: 97.6744% (minimum 99%, Missing); pancreas: 97.6744% (minimum 99%, Missing); retina: 84.0000% (minimum 99%, Missing); skeletal muscle: 97.6744% (minimum 99%, Missing); small intestine: 97.6744% (minimum 99%, Missing); spinal cord: 97.6744% (minimum 99%, Missing)",0,80,unavailable,0.8,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000183304,FAM9A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0267442,0.00674419,-0.15
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183305,MAGEA2B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183305,MAGEA2B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183305,MAGEA2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183313,OR52L1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183313,OR52L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183313,OR52L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,3,partial,0.8,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000183318,SPDYE4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.7013% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.4762% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.4359% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.2025% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7013% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.4359% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.4359% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.8,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000183318,SPDYE4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.024359,0.00435897,-0.0852381
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 90.4762% (minimum 95%, Enhanced); retina: 98.7013% (minimum 99%, Missing)",0,3,partial,0.8,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000183318,SPDYE4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0452381
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.5,0,0,"heart muscle: 4.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000183324,REC114,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 89.4366% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,4.5,0,0,"heart muscle: 4.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000183324,REC114,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0956338
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 89.4366% (minimum 99%, Missing)",0,80,unavailable,4.5,0,0,"heart muscle: 4.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000183324,REC114,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0956338
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,0.6,0.3,"bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen,ENSG00000183396,TMEM89,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.4109% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.5709% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.7,0.6,0.3,"bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen,ENSG00000183396,TMEM89,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0377049,0.0057085,-0.0558915
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.4109% (minimum 99%, Missing); small intestine: 97.5709% (minimum 99%, Missing)",0,80,unavailable,1.7,0.6,0.3,"bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen,ENSG00000183396,TMEM89,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0377049,0.0057085,-0.0558915
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183434,TFDP3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183434,TFDP3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183434,TFDP3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,9,partial,2.3,1.7,0.1,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; salivary gland; skin,ENSG00000183476,SH2D7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.7500% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.7742% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.7742% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.7500% (minimum 99%, Baseline (adaptation disabled)); colon: 63.8298% (minimum 97%, Baseline (adaptation disabled)); duodenum: 56.6038% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.7742% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.7742% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.7742% (minimum 99%, Baseline (adaptation disabled)); lung: 96.7742% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.7742% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7742% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.7500% (minimum 97%, Baseline (adaptation disabled)); retina: 90.9091% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.7742% (minimum 97%, Baseline (adaptation disabled)); small intestine: 62.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.7742% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.7742% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.7500% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,2.3,1.7,0.1,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; salivary gland; skin,ENSG00000183476,SH2D7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0177419,-0.331702,-0.423962
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.7500% (minimum 99%, Missing); basal ganglia: 96.7742% (minimum 99%, Missing); cerebral cortex: 93.7500% (minimum 95%, Enhanced); colon: 63.8298% (minimum 97%, Missing); duodenum: 56.6038% (minimum 99%, Missing); hippocampal formation: 96.7742% (minimum 99%, Missing); hypothalamus: 96.7742% (minimum 99%, Missing); midbrain: 96.7742% (minimum 99%, Missing); rectum: 93.7500% (minimum 97%, Missing); retina: 90.9091% (minimum 99%, Missing); small intestine: 62.5000% (minimum 99%, Missing); spinal cord: 96.7742% (minimum 99%, Missing); stomach: 93.7500% (minimum 97%, Missing)",0,9,partial,2.3,1.7,0.1,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; salivary gland; skin,ENSG00000183476,SH2D7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,-0.331702,-0.423962
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,4,3.3,6.3,"thymus: 6.3 nTPM (manageable, limit 5); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183496,MEX3B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.8085% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.6395% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.7895% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.9192% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.2377% (minimum 99%, Baseline (adaptation disabled)); colon: 93.2377% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.6985% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.5946% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.1945% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2222% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.4848% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0603% (minimum 99%, Baseline (adaptation disabled)); lung: 97.0149% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.3983% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.2721% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.9130% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.2721% (minimum 99%, Baseline (adaptation disabled)); retina: 98.4848% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.5946% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.8085% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.6395% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.2222% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0603% (minimum 99%, Baseline (adaptation disabled)); thymus: 87.8378% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.7895% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,4,3.3,6.3,"thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); heart muscle: 2.6 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183496,MEX3B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0716216,-0.037623,-0.0708081
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.8085% (minimum 99%, Missing); basal ganglia: 97.6395% (minimum 99%, Missing); cerebellum: 91.9192% (minimum 95%, Enhanced); cerebral cortex: 93.2377% (minimum 95%, Enhanced); heart muscle: 94.5946% (minimum 95%, Enhanced); hippocampal formation: 96.1945% (minimum 99%, Missing); hypothalamus: 97.2222% (minimum 99%, Missing); midbrain: 98.2721% (minimum 99%, Missing); pituitary gland: 98.2721% (minimum 99%, Missing); retina: 98.4848% (minimum 99%, Missing); spinal cord: 98.0603% (minimum 99%, Missing); thymus: 87.8378% (minimum 95%, Missing); tongue: 95.7895% (minimum 97%, Missing)",0,3,partial,4,3.3,6.3,"thymus: 6.3 nTPM (manageable, limit 5); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183496,MEX3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0716216,-0.0121053,-0.0308081
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000183559,C10orf120,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000183559,C10orf120,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00668874
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000183559,C10orf120,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00668874
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183629,GOLGA8G,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183629,GOLGA8G,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183629,GOLGA8G,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,not_triggered,,,ENSG00000183632,TP53TG3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 95.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.1014% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.5294% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5294% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1014% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.1,0.1,,,0,not_established,not_triggered,,,ENSG00000183632,TP53TG3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0352941,0.0152941,-0.0328571
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 95.7143% (minimum 99%, Missing); cerebellum: 97.1014% (minimum 99%, Missing); cerebral cortex: 98.5294% (minimum 99%, Missing); hypothalamus: 98.5294% (minimum 99%, Missing); spinal cord: 97.1014% (minimum 99%, Missing)",0,80,unavailable,0.3,0.1,0.1,,,0,not_established,not_triggered,,,ENSG00000183632,TP53TG3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0352941,0.0152941,-0.0328571
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,59.4,"skin: 59.4 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000183640,KRTAP8-1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adipose tissue: 25.0000% (minimum 95%, Baseline (adaptation disabled)); skin: 0.3356% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,59.4,"skin: 59.4 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000183640,KRTAP8-1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.946644,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adipose tissue: 25.0000% (minimum 95%, Missing); skin: 0.3356% (minimum 95%, Missing)",0,80,unavailable,0,0,59.4,"skin: 59.4 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000183640,KRTAP8-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.946644,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.7,1,0.1,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000183654,MARCHF11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.0432% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.9052% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.1395% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.0314% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.3463% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.8561% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.1395% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.8561% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.5240% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 89.1982% (minimum 99%, Baseline (adaptation disabled)); retina: 95.8134% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7670% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,9.7,1,0.1,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000183654,MARCHF11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,0.0487531,0.0176695,-0.0980178
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.0432% (minimum 99%, Missing); basal ganglia: 94.9052% (minimum 99%, Missing); cerebellum: 93.1395% (minimum 99%, Missing); cerebral cortex: 93.0314% (minimum 99%, Missing); heart muscle: 94.3463% (minimum 99%, Missing); hippocampal formation: 96.8561% (minimum 99%, Missing); hypothalamus: 93.1395% (minimum 99%, Missing); midbrain: 96.8561% (minimum 99%, Missing); pancreas: 98.5240% (minimum 99%, Missing); pituitary gland: 89.1982% (minimum 99%, Missing); retina: 95.8134% (minimum 99%, Missing); spinal cord: 98.7670% (minimum 99%, Missing)",0,80,unavailable,9.7,1,0.1,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000183654,MARCHF11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,0.0487531,0.0176695,-0.0980178
True,compatible,,True,True,False,,0,1,partial,0.7,0.3,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000183668,PSG9,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,,True,True,True,,0,1,partial,0.7,0.3,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000183668,PSG9,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.047107,0.027107,0.0032757
True,compatible,,True,True,True,,0,1,partial,0.7,0.3,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000183668,PSG9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183706,OR4N4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183706,OR4N4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183706,OR4N4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000183753,BPY2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 84.6154% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000183753,BPY2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.143846
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 84.6154% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000183753,BPY2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.143846
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000183795,BPY2B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 84.6154% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000183795,BPY2B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.143846
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 84.6154% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000183795,BPY2B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.143846
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,10.2,7.9,7.1,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); thymus: 7.1 nTPM (manageable, limit 5); thyroid gland: 6.5 nTPM (manageable, limit 5); spleen: 6.5 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); cerebellum: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000183808,RBM12B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.6415% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.1416% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.3814% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.7778% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 70.6422% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.8120% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.3793% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.6957% (minimum 99%, Baseline (adaptation disabled)); colon: 68.1416% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.1667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.6422% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.7059% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.5714% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.0526% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.8120% (minimum 99%, Baseline (adaptation disabled)); liver: 73.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 68.1416% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.3590% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.0526% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.3694% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.1148% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.1416% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.8120% (minimum 97%, Baseline (adaptation disabled)); retina: 43.0168% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.1148% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 66.9565% (minimum 99%, Baseline (adaptation disabled)); skin: 65.2542% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.7059% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.7500% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.2376% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.2254% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.0968% (minimum 97%, Baseline (adaptation disabled)); thymus: 52.0270% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.2254% (minimum 95%, Baseline (adaptation disabled)); tongue: 74.0385% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.9565% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,10.2,7.9,7.1,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); thymus: 7.1 nTPM (manageable, limit 5); thyroid gland: 6.5 nTPM (manageable, limit 5); spleen: 6.5 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); cerebellum: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000183808,RBM12B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.42973,-0.47641,-0.559832
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.6415% (minimum 95%, Uncertain); adrenal gland: 68.1416% (minimum 99%, Missing); amygdala: 79.3814% (minimum 99%, Missing); basal ganglia: 77.7778% (minimum 99%, Missing); bone marrow: 70.6422% (minimum 99%, Missing); cerebellum: 65.8120% (minimum 99%, Missing); cerebral cortex: 66.3793% (minimum 99%, Missing); choroid plexus: 83.6957% (minimum 99%, Missing); colon: 68.1416% (minimum 97%, Missing); duodenum: 64.1667% (minimum 99%, Missing); esophagus: 70.6422% (minimum 97%, Missing); heart muscle: 64.7059% (minimum 99%, Uncertain); hippocampal formation: 78.5714% (minimum 99%, Missing); hypothalamus: 81.0526% (minimum 99%, Missing); kidney: 65.8120% (minimum 99%, Missing); liver: 73.3333% (minimum 99%, Missing); lung: 68.1416% (minimum 99%, Uncertain); lymph node: 49.3590% (minimum 97%, Uncertain); midbrain: 81.0526% (minimum 99%, Missing); pancreas: 69.3694% (minimum 99%, Missing); parathyroid gland: 63.1148% (minimum 97%, Missing); pituitary gland: 68.1416% (minimum 99%, Missing); rectum: 65.8120% (minimum 97%, Missing); retina: 43.0168% (minimum 99%, Missing); salivary gland: 63.1148% (minimum 97%, Missing); skeletal muscle: 66.9565% (minimum 99%, Uncertain); skin: 65.2542% (minimum 95%, Missing); small intestine: 64.7059% (minimum 99%, Missing); smooth muscle: 68.7500% (minimum 99%, Uncertain); spinal cord: 76.2376% (minimum 99%, Missing); spleen: 54.2254% (minimum 95%, Uncertain); stomach: 62.0968% (minimum 97%, Missing); thymus: 52.0270% (minimum 95%, Missing); thyroid gland: 54.2254% (minimum 95%, Missing); tongue: 74.0385% (minimum 97%, Missing); urinary bladder: 66.9565% (minimum 97%, Missing)",0,1,partial,10.2,7.9,7.1,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 2); thymus: 7.1 nTPM (manageable, limit 5); thyroid gland: 6.5 nTPM (manageable, limit 5); spleen: 6.5 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 2); parathyroid gland: 4.5 nTPM (protected, limit 2); salivary gland: 4.5 nTPM (protected, limit 2); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 2); cerebellum: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000183808,RBM12B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.42973,-0.47641,-0.559832
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,6.2,9,0.5,"choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; spleen; thymus,ENSG00000183831,ANKRD45,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.3488% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.5503% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.4915% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.0938% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.4865% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.8504% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.4570% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.4570% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.1111% (minimum 99%, Baseline (adaptation disabled)); lung: 91.7910% (minimum 99%, Baseline (adaptation disabled)); midbrain: 88.4892% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.6190% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.7465% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.2340% (minimum 99%, Baseline (adaptation disabled)); retina: 83.1081% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.4812% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.4812% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,6.2,9,0.5,"parathyroid gland: 9 nTPM (protected, limit 2); choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; spleen; thymus,ENSG00000183831,ANKRD45,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0109375,-0.392535,-0.325135
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 82.5503% (minimum 99%, Missing); basal ganglia: 69.4915% (minimum 99%, Missing); cerebral cortex: 82.0000% (minimum 95%, Enhanced); choroid plexus: 66.4865% (minimum 99%, Missing); hippocampal formation: 81.4570% (minimum 99%, Missing); hypothalamus: 81.4570% (minimum 99%, Missing); kidney: 91.1111% (minimum 95%, Enhanced); lung: 91.7910% (minimum 95%, Enhanced); midbrain: 88.4892% (minimum 99%, Missing); parathyroid gland: 57.7465% (minimum 80%, Enhanced); pituitary gland: 87.2340% (minimum 99%, Missing); retina: 83.1081% (minimum 99%, Missing); smooth muscle: 92.4812% (minimum 95%, Enhanced); spinal cord: 92.4812% (minimum 99%, Missing)",0,6,partial,6.2,9,0.5,"choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; spleen; thymus,ENSG00000183831,ANKRD45,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.034,-0.222535,-0.325135
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,15.8,3.9,4.5,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 3); retina: 4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183833,CFAP91,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.2611% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.5676% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.8205% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.8356% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.8356% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 46.4407% (minimum 99%, Baseline (adaptation disabled)); colon: 91.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.1631% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.7285% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.6250% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.0932% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8571% (minimum 99%, Baseline (adaptation disabled)); lung: 87.2611% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.4828% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.4565% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.8409% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.1836% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.4789% (minimum 97%, Baseline (adaptation disabled)); retina: 77.4011% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.1316% (minimum 97%, Baseline (adaptation disabled)); small intestine: 95.8042% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.1389% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.1389% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.6250% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.5425% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 75.2747% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.5676% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,15.8,3.9,4.5,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183833,CFAP91,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.197253,-0.191591,-0.525593
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.2611% (minimum 97%, Supported); amygdala: 92.5676% (minimum 99%, Missing); basal ganglia: 87.8205% (minimum 99%, Missing); cerebellum: 93.8356% (minimum 97%, Supported); cerebral cortex: 93.8356% (minimum 97%, Supported); choroid plexus: 46.4407% (minimum 99%, Missing); hippocampal formation: 90.7285% (minimum 99%, Missing); hypothalamus: 85.6250% (minimum 99%, Missing); kidney: 85.0932% (minimum 97%, Supported); lung: 87.2611% (minimum 97%, Supported); midbrain: 94.4828% (minimum 99%, Missing); pancreas: 74.4565% (minimum 97%, Supported); parathyroid gland: 77.8409% (minimum 90%, Supported); pituitary gland: 66.1836% (minimum 99%, Missing); retina: 77.4011% (minimum 99%, Missing); small intestine: 95.8042% (minimum 97%, Supported); smooth muscle: 95.1389% (minimum 97%, Supported); spinal cord: 95.1389% (minimum 99%, Missing); stomach: 89.5425% (minimum 90%, Supported); thyroid gland: 75.2747% (minimum 80%, Supported)",0,4,partial,15.8,3.9,4.5,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 3); retina: 4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183833,CFAP91,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0472527,-0.121591,-0.525593
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,4.5,6.5,1.3,"colon: 6.5 nTPM (protected, limit 4); stomach: 5.9 nTPM (protected, limit 4); rectum: 5.5 nTPM (protected, limit 4); parathyroid gland: 4.9 nTPM (protected, limit 4); duodenum: 4.5 nTPM (vital, limit 2); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 2); small intestine: 3.6 nTPM (vital, limit 2); liver: 3.2 nTPM (vital, limit 2); kidney: 2.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells,ENSG00000183840,GPR39,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.4545% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.3043% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.6744% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.4545% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 39.2523% (minimum 97%, Baseline (adaptation disabled)); duodenum: 48.2759% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.0000% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 97.6744% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.6744% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.7647% (minimum 99%, Baseline (adaptation disabled)); liver: 56.7568% (minimum 99%, Baseline (adaptation disabled)); lung: 52.5000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.4545% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.5000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 46.1538% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.6744% (minimum 99%, Baseline (adaptation disabled)); rectum: 43.2990% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 89.3617% (minimum 97%, Baseline (adaptation disabled)); skin: 80.7692% (minimum 95%, Baseline (adaptation disabled)); small intestine: 53.8462% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); stomach: 41.5842% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 76.3636% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 62.6866% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,4.5,6.5,1.3,"colon: 6.5 nTPM (protected, limit 2); stomach: 5.9 nTPM (protected, limit 2); rectum: 5.5 nTPM (protected, limit 2); parathyroid gland: 4.9 nTPM (protected, limit 2); duodenum: 4.5 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells,ENSG00000183840,GPR39,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.186364,-0.577477,-0.507241
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.4545% (minimum 99%, Missing); basal ganglia: 91.3043% (minimum 99%, Missing); cerebellum: 97.6744% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 39.2523% (minimum 95%, Approved); duodenum: 48.2759% (minimum 98%, Approved); esophagus: 84.0000% (minimum 97%, Missing); hippocampal formation: 97.6744% (minimum 99%, Missing); hypothalamus: 97.6744% (minimum 99%, Missing); kidney: 61.7647% (minimum 99%, Missing); liver: 56.7568% (minimum 98%, Approved); lung: 52.5000% (minimum 99%, Missing); midbrain: 95.4545% (minimum 99%, Missing); pancreas: 52.5000% (minimum 98%, Approved); parathyroid gland: 46.1538% (minimum 95%, Approved); pituitary gland: 97.6744% (minimum 99%, Missing); rectum: 43.2990% (minimum 95%, Approved); salivary gland: 89.3617% (minimum 95%, Approved); skin: 80.7692% (minimum 95%, Missing); small intestine: 53.8462% (minimum 98%, Approved); smooth muscle: 93.3333% (minimum 98%, Approved); stomach: 41.5842% (minimum 95%, Approved); thyroid gland: 76.3636% (minimum 90%, Approved); urinary bladder: 62.6866% (minimum 95%, Approved)",0,1,partial,4.5,6.5,1.3,"colon: 6.5 nTPM (protected, limit 4); stomach: 5.9 nTPM (protected, limit 4); rectum: 5.5 nTPM (protected, limit 4); parathyroid gland: 4.9 nTPM (protected, limit 4); duodenum: 4.5 nTPM (vital, limit 2); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 2); small intestine: 3.6 nTPM (vital, limit 2); liver: 3.2 nTPM (vital, limit 2); kidney: 2.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells,ENSG00000183840,GPR39,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.142308,-0.557477,-0.497241
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,1.8,2.5,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183850,ZNF730,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.0784% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.2308% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.0784% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.3846% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.0784% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.2424% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.2308% (minimum 99%, Baseline (adaptation disabled)); colon: 92.4528% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.7407% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.4528% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.0784% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.7407% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0784% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 89.0909% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.1343% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.2308% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.2308% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.5000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 98.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 84.4828% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0784% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.2308% (minimum 99%, Baseline (adaptation disabled)); skin: 92.4528% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 83.0508% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.2308% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.4528% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.0784% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.2162% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 83.0508% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.0784% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.4528% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.7,1.8,2.5,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183850,ZNF730,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.287838,-0.238657,-0.247576
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.0784% (minimum 99%, Missing); amygdala: 94.2308% (minimum 99%, Missing); basal ganglia: 96.0784% (minimum 99%, Missing); bone marrow: 75.3846% (minimum 99%, Missing); cerebellum: 96.0784% (minimum 99%, Missing); cerebral cortex: 74.2424% (minimum 99%, Missing); choroid plexus: 94.2308% (minimum 99%, Missing); colon: 92.4528% (minimum 97%, Missing); duodenum: 98.0000% (minimum 99%, Missing); esophagus: 90.7407% (minimum 97%, Missing); heart muscle: 92.4528% (minimum 99%, Missing); hippocampal formation: 96.0784% (minimum 99%, Missing); hypothalamus: 90.7407% (minimum 99%, Missing); kidney: 96.0784% (minimum 99%, Missing); liver: 98.0000% (minimum 99%, Missing); lung: 89.0909% (minimum 99%, Missing); lymph node: 73.1343% (minimum 97%, Missing); midbrain: 94.2308% (minimum 99%, Missing); pancreas: 94.2308% (minimum 99%, Missing); parathyroid gland: 87.5000% (minimum 97%, Missing); pituitary gland: 98.0000% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 84.4828% (minimum 99%, Missing); salivary gland: 96.0784% (minimum 97%, Missing); skeletal muscle: 94.2308% (minimum 99%, Missing); skin: 92.4528% (minimum 95%, Missing); smooth muscle: 83.0508% (minimum 99%, Missing); spinal cord: 94.2308% (minimum 99%, Missing); spleen: 92.4528% (minimum 95%, Missing); stomach: 96.0784% (minimum 97%, Missing); thymus: 66.2162% (minimum 95%, Missing); thyroid gland: 83.0508% (minimum 95%, Missing); tongue: 96.0784% (minimum 97%, Missing); urinary bladder: 92.4528% (minimum 97%, Missing)",0,80,unavailable,1.7,1.8,2.5,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183850,ZNF730,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.287838,-0.238657,-0.247576
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183862,CNGA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183862,CNGA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000183862,CNGA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,20.1,10.2,0.4,"retina: 20.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183914,DNAH2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.3043% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.2548% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.1832% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.7324% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.9708% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.2903% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.5000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.3617% (minimum 99%, Baseline (adaptation disabled)); liver: 96.9231% (minimum 99%, Baseline (adaptation disabled)); lung: 87.5000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.4375% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.9231% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.2632% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.9231% (minimum 99%, Baseline (adaptation disabled)); retina: 38.5321% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.4375% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.6744% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,20.1,10.2,0.4,"retina: 20.1 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 2); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183914,DNAH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0192308,-0.417368,-0.604679
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 91.3043% (minimum 99%, Missing); basal ganglia: 80.2548% (minimum 99%, Missing); cerebellum: 88.7324% (minimum 95%, Enhanced); cerebral cortex: 91.9708% (minimum 95%, Enhanced); choroid plexus: 81.2903% (minimum 99%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing); hypothalamus: 89.3617% (minimum 99%, Missing); lung: 87.5000% (minimum 95%, Enhanced); midbrain: 98.4375% (minimum 99%, Missing); parathyroid gland: 55.2632% (minimum 80%, Enhanced); pituitary gland: 96.9231% (minimum 99%, Missing); retina: 38.5321% (minimum 99%, Missing); spinal cord: 97.6744% (minimum 99%, Missing)",0,4,partial,20.1,10.2,0.4,"retina: 20.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000183914,DNAH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0267442,-0.247368,-0.604679
True,compatible,,True,True,False,,0,4,partial,1.9,0.1,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000183977,PP2D1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6301% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.1209% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.2973% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.6301% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.6301% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.6301% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6301% (minimum 99%, Baseline (adaptation disabled)); lung: 97.2973% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6301% (minimum 99%, Baseline (adaptation disabled)); retina: 94.7368% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.2973% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.6301% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,1.9,0.1,0.2,"bone marrow: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000183977,PP2D1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.022973,0.0163014,-0.198791
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 79.1209% (minimum 95%, Enhanced); hypothalamus: 98.6301% (minimum 99%, Missing); retina: 94.7368% (minimum 99%, Missing)",0,4,partial,1.9,0.1,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000183977,PP2D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.0163014,-0.158791
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,1.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000184032,KRTAP20-2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"skin: 6.6667% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,1.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000184032,KRTAP20-2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.883333,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"skin: 6.6667% (minimum 95%, Missing)",0,80,unavailable,0,0,1.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000184032,KRTAP20-2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.883333,0.03,0.01
True,compatible,,True,True,False,,0,3,partial,0.2,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000184033,CTAG1B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;Seager 2024;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 97.3684% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.2,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000184033,CTAG1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;Seager 2024;Loriot 2025;da Silva 2017,0.0366667,0.0166667,-0.0163158
True,compatible,,True,True,True,,0,3,partial,0.2,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000184033,CTAG1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184108,TRIML1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184108,TRIML1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184108,TRIML1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,0.1,1.1,140.9,"skin: 140.9 nTPM (manageable, limit 5)",esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / cells in granular layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000184148,SPRR4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 86.7470% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.6301% (minimum 99%, Baseline (adaptation disabled)); skin: 4.8616% (minimum 95%, Baseline (adaptation disabled)); thymus: 88.8889% (minimum 95%, Baseline (adaptation disabled))",0,5,partial,0.1,1.1,140.9,"skin: 140.9 nTPM (manageable, limit 5)",esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / cells in granular layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000184148,SPRR4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.901384,-0.10253,-0.00369863
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 86.7470% (minimum 97%, Missing); skin: 4.8616% (minimum 95%, Missing); thymus: 88.8889% (minimum 95%, Missing)",0,5,partial,0.1,1.1,140.9,"skin: 140.9 nTPM (manageable, limit 5)",esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / cells in granular layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000184148,SPRR4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.901384,-0.10253,0.01
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,2.3,0.8,1.2,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184166,OR1D2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.9231% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 40.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 55.5556% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 50.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 83.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.4286% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.9231% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.8235% (minimum 99%, Baseline (adaptation disabled)); liver: 58.8235% (minimum 99%, Baseline (adaptation disabled)); lung: 71.4286% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.5556% (minimum 97%, Baseline (adaptation disabled)); pancreas: 76.9231% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); rectum: 76.9231% (minimum 97%, Baseline (adaptation disabled)); retina: 30.3030% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 47.6190% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.5556% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.4286% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.4286% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 45.4545% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.9231% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.9231% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.3,0.8,1.2,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184166,OR1D2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.495455,-0.414444,-0.68697
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 76.9231% (minimum 99%, Missing); bone marrow: 40.0000% (minimum 99%, Missing); cerebral cortex: 55.5556% (minimum 99%, Missing); choroid plexus: 50.0000% (minimum 99%, Missing); colon: 83.3333% (minimum 97%, Missing); duodenum: 71.4286% (minimum 99%, Missing); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 76.9231% (minimum 99%, Missing); kidney: 58.8235% (minimum 99%, Missing); liver: 58.8235% (minimum 99%, Missing); lung: 71.4286% (minimum 99%, Missing); lymph node: 55.5556% (minimum 97%, Missing); pancreas: 76.9231% (minimum 99%, Missing); parathyroid gland: 83.3333% (minimum 97%, Missing); rectum: 76.9231% (minimum 97%, Missing); retina: 30.3030% (minimum 99%, Missing); salivary gland: 62.5000% (minimum 97%, Missing); skeletal muscle: 62.5000% (minimum 99%, Missing); skin: 47.6190% (minimum 95%, Missing); small intestine: 71.4286% (minimum 99%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spleen: 55.5556% (minimum 95%, Missing); stomach: 71.4286% (minimum 97%, Missing); thymus: 71.4286% (minimum 95%, Missing); thyroid gland: 45.4545% (minimum 95%, Missing); tongue: 76.9231% (minimum 97%, Missing); urinary bladder: 76.9231% (minimum 97%, Missing)",0,80,unavailable,2.3,0.8,1.2,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184166,OR1D2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.495455,-0.414444,-0.68697
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,0,routine_complete,27.7,0,0,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),64,not_established,not_triggered,,,ENSG00000184302,SIX6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"hypothalamus: 3.1250% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 0.3597% (minimum 99%, Baseline (adaptation disabled)); retina: 1.5385% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 33.3333% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,27.7,0,0,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),64,not_established,not_triggered,,,ENSG00000184302,SIX6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.986403
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"hypothalamus: 3.1250% (minimum 99%, Missing); pituitary gland: 0.3597% (minimum 99%, Missing); retina: 1.5385% (minimum 99%, Missing); skeletal muscle: 33.3333% (minimum 98%, Approved)",0,0,routine_complete,27.7,0,0,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),64,not_established,not_triggered,,,ENSG00000184302,SIX6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.986403
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,3.3,0.9,0.7,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000184305,CCSER1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.5926% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.4444% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.5926% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.2857% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 78.1250% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.1250% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.7576% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.5926% (minimum 99%, Baseline (adaptation disabled)); colon: 92.5926% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.2857% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.1538% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 73.5294% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.2069% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.2857% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.5294% (minimum 99%, Baseline (adaptation disabled)); liver: 96.1538% (minimum 99%, Baseline (adaptation disabled)); lung: 92.5926% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.2069% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.1538% (minimum 99%, Baseline (adaptation disabled)); pancreas: 83.3333% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.5926% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.2069% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.5926% (minimum 97%, Baseline (adaptation disabled)); retina: 43.1034% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.5294% (minimum 97%, Baseline (adaptation disabled)); skin: 83.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.2857% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.5926% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.2857% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.2069% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.5926% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.1250% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.1538% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.3333% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,3.3,0.9,0.7,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000184305,CCSER1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.16875,-0.234706,-0.558966
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.5926% (minimum 95%, Missing); adrenal gland: 69.4444% (minimum 99%, Uncertain); amygdala: 92.5926% (minimum 99%, Missing); basal ganglia: 89.2857% (minimum 99%, Missing); bone marrow: 78.1250% (minimum 99%, Uncertain); cerebellum: 78.1250% (minimum 99%, Uncertain); cerebral cortex: 75.7576% (minimum 99%, Missing); choroid plexus: 92.5926% (minimum 99%, Missing); colon: 92.5926% (minimum 97%, Missing); duodenum: 89.2857% (minimum 99%, Missing); esophagus: 96.1538% (minimum 97%, Uncertain); heart muscle: 73.5294% (minimum 99%, Uncertain); hippocampal formation: 86.2069% (minimum 99%, Missing); hypothalamus: 89.2857% (minimum 99%, Missing); kidney: 73.5294% (minimum 99%, Uncertain); liver: 96.1538% (minimum 99%, Uncertain); lung: 92.5926% (minimum 99%, Missing); lymph node: 86.2069% (minimum 97%, Uncertain); midbrain: 96.1538% (minimum 99%, Missing); pancreas: 83.3333% (minimum 99%, Uncertain); parathyroid gland: 92.5926% (minimum 97%, Uncertain); pituitary gland: 86.2069% (minimum 99%, Missing); rectum: 92.5926% (minimum 97%, Missing); retina: 43.1034% (minimum 99%, Missing); salivary gland: 73.5294% (minimum 97%, Uncertain); skin: 83.3333% (minimum 95%, Missing); small intestine: 89.2857% (minimum 99%, Missing); smooth muscle: 96.1538% (minimum 99%, Missing); spinal cord: 92.5926% (minimum 99%, Missing); spleen: 89.2857% (minimum 95%, Uncertain); stomach: 86.2069% (minimum 97%, Missing); thymus: 92.5926% (minimum 95%, Missing); thyroid gland: 78.1250% (minimum 95%, Missing); tongue: 96.1538% (minimum 97%, Missing); urinary bladder: 83.3333% (minimum 97%, Uncertain)",0,2,partial,3.3,0.9,0.7,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000184305,CCSER1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.16875,-0.234706,-0.558966
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,0,5.5,1.6,"esophagus: 5.5 nTPM (protected, limit 2)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000184330,S100A7A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 32.0988% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.2963% (minimum 97%, Baseline (adaptation disabled)); skin: 61.9048% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,0,5.5,1.6,"esophagus: 5.5 nTPM (protected, limit 2)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000184330,S100A7A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.330952,-0.649012,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 32.0988% (minimum 97%, Missing); skin: 61.9048% (minimum 95%, Missing)",0,2,partial,0,5.5,1.6,"esophagus: 5.5 nTPM (protected, limit 2)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000184330,S100A7A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.330952,-0.649012,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184345,IQCF2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184345,IQCF2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184345,IQCF2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0.5,0.3,0.1,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,ENSG00000184361,SPATA32,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.8345% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.5,0.3,0.1,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,ENSG00000184361,SPATA32,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0476471,0.0229742,-0.00165501
True,compatible,,True,True,True,,0,1,partial,0.5,0.3,0.1,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,ENSG00000184361,SPATA32,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00834499
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,31.3,8.5,2.2,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 2); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000184368,MAP7D2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 92.6893% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.3014% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.7208% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0663% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 59.9662% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.1437% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.9198% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.0663% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.8858% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.4286% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.9433% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.2596% (minimum 99%, Baseline (adaptation disabled)); midbrain: 71.5726% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.9945% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.3308% (minimum 99%, Baseline (adaptation disabled)); retina: 71.5726% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.6111% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.7302% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.5422% (minimum 99%, Baseline (adaptation disabled)); stomach: 80.6818% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.1645% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,31.3,8.5,2.2,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 2); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000184368,MAP7D2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.00835544,-0.163182,-0.458563
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 92.6893% (minimum 95%, Enhanced); amygdala: 72.3014% (minimum 99%, Missing); basal ganglia: 62.7208% (minimum 99%, Missing); cerebellum: 59.9662% (minimum 99%, Missing); cerebral cortex: 53.1437% (minimum 99%, Missing); choroid plexus: 94.9198% (minimum 99%, Missing); hippocampal formation: 71.4286% (minimum 99%, Missing); hypothalamus: 62.9433% (minimum 99%, Missing); kidney: 91.2596% (minimum 99%, Missing); midbrain: 71.5726% (minimum 99%, Missing); pituitary gland: 90.3308% (minimum 99%, Missing); retina: 71.5726% (minimum 99%, Missing); spinal cord: 85.5422% (minimum 99%, Missing); stomach: 80.6818% (minimum 97%, Missing); thymus: 94.1645% (minimum 95%, Missing)",0,4,partial,31.3,8.5,2.2,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 2); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000184368,MAP7D2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.00835544,-0.163182,-0.458563
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,2.7,1.6,1.5,"liver: 2.7 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184378,ACTRT3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.0851% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.4630% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2574% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.8769% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.4630% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.2479% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.6695% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.4630% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5043% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.4630% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.2479% (minimum 99%, Baseline (adaptation disabled)); liver: 94.4672% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6695% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.6695% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.7152% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.2574% (minimum 99%, Baseline (adaptation disabled)); retina: 98.5043% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.5043% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2942% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.8487% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5043% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 96.6457% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,2.7,1.6,1.5,"liver: 2.7 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184378,ACTRT3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,0.0184874,-0.00354298,-0.0453279
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 97.4630% (minimum 99%, Missing); basal ganglia: 97.2574% (minimum 99%, Missing); cerebellum: 97.8769% (minimum 98%, Approved); cerebral cortex: 97.4630% (minimum 98%, Approved); choroid plexus: 95.2479% (minimum 99%, Missing); duodenum: 97.6695% (minimum 98%, Approved); heart muscle: 97.4630% (minimum 98%, Approved); hippocampal formation: 98.5043% (minimum 99%, Missing); hypothalamus: 97.4630% (minimum 99%, Missing); kidney: 95.2479% (minimum 98%, Approved); liver: 94.4672% (minimum 98%, Approved); lung: 97.6695% (minimum 98%, Approved); midbrain: 97.6695% (minimum 99%, Missing); pituitary gland: 97.2574% (minimum 99%, Missing); retina: 98.5043% (minimum 99%, Missing); smooth muscle: 96.8487% (minimum 98%, Approved); spinal cord: 98.5043% (minimum 99%, Missing)",0,1,partial,2.7,1.6,1.5,"liver: 2.7 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184378,ACTRT3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,0.0329424,0.0150427,-0.0375207
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.2,0.1,44.2,"skin: 44.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,ENSG00000184459,BPIFC,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 95.6522% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.6522% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 95.6522% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 4.7414% (minimum 95%, Baseline (adaptation disabled)); thymus: 91.6667% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,44.2,"skin: 44.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,ENSG00000184459,BPIFC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.902586,-0.0134783,-0.0733333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 95.6522% (minimum 99%, Missing); esophagus: 95.6522% (minimum 97%, Missing); salivary gland: 95.6522% (minimum 97%, Missing); skeletal muscle: 91.6667% (minimum 99%, Missing); skin: 4.7414% (minimum 95%, Missing); thymus: 91.6667% (minimum 95%, Missing)",0,80,unavailable,0.2,0.1,44.2,"skin: 44.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,ENSG00000184459,BPIFC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.902586,-0.0134783,-0.0733333
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184478,OR56A3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184478,OR56A3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184478,OR56A3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,55.5,9294.1,9.1,"stomach: 9294.1 nTPM (protected, limit 2); duodenum: 55.5 nTPM (vital, limit 6)",stomach 2 / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,ENSG00000184502,GAST,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2381% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.0233% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.2381% (minimum 99%, Baseline (adaptation disabled)); duodenum: 6.7227% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.5610% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.0233% (minimum 99%, Baseline (adaptation disabled)); lung: 53.3333% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.5610% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.5610% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.5610% (minimum 99%, Baseline (adaptation disabled)); spleen: 30.5344% (minimum 95%, Baseline (adaptation disabled)); stomach: 0.0430% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.7805% (minimum 95%, Baseline (adaptation disabled))",0,8,partial,55.5,9294.1,9.1,"stomach: 9294.1 nTPM (protected, limit 2); duodenum: 55.5 nTPM (vital, limit 1); spleen: 9.1 nTPM (manageable, limit 5); lung: 3.5 nTPM (vital, limit 1)",stomach 2 / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,ENSG00000184502,GAST,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.644656,-0.96957,-0.922773
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.2381% (minimum 99%, Missing); basal ganglia: 93.0233% (minimum 99%, Missing); duodenum: 6.7227% (minimum 95%, Enhanced); hippocampal formation: 97.5610% (minimum 99%, Missing); hypothalamus: 88.8889% (minimum 99%, Missing); kidney: 93.0233% (minimum 95%, Enhanced); lung: 53.3333% (minimum 95%, Enhanced); midbrain: 97.5610% (minimum 99%, Missing); pituitary gland: 97.5610% (minimum 99%, Missing); spleen: 30.5344% (minimum 60%, Enhanced); stomach: 0.0430% (minimum 97%, Missing); thymus: 48.7805% (minimum 95%, Missing)",0,8,partial,55.5,9294.1,9.1,"stomach: 9294.1 nTPM (protected, limit 2); duodenum: 55.5 nTPM (vital, limit 6)",stomach 2 / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,ENSG00000184502,GAST,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.462195,-0.96957,-0.882773
True,compatible,,True,True,False,,0,5,partial,0.2,0.1,0.2,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000184507,NUTM1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.9691% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,0.2,0.1,0.2,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000184507,NUTM1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0396907,0.0248187,-0.000309278
True,compatible,,True,True,True,,0,5,partial,0.2,0.1,0.2,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000184507,NUTM1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000184560,SPEM2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000184560,SPEM2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00839615
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000184560,SPEM2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00839615
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,ENSG00000184571,PIWIL3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,ENSG00000184571,PIWIL3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.17,0.01
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"lymph node: 80.0000% (minimum 97%, Missing)",0,80,unavailable,0,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,ENSG00000184571,PIWIL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.17,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,44.5,0.3,0.3,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus,ENSG00000184599,TAFA3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 37.1429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.9759% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.7342% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.8261% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.1220% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.5000% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.7342% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.2963% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.9759% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.7342% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.2963% (minimum 97%, Baseline (adaptation disabled)); midbrain: 74.2857% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.2963% (minimum 99%, Baseline (adaptation disabled)); retina: 14.9140% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.6404% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,44.5,0.3,0.3,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus,ENSG00000184599,TAFA3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.012963,-0.00703704,-0.84086
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 37.1429% (minimum 99%, Missing); amygdala: 93.9759% (minimum 99%, Missing); basal ganglia: 98.7342% (minimum 99%, Missing); cerebellum: 67.8261% (minimum 98%, Approved); cerebral cortex: 95.1220% (minimum 98%, Approved); choroid plexus: 97.5000% (minimum 99%, Missing); hippocampal formation: 96.2963% (minimum 99%, Missing); hypothalamus: 93.9759% (minimum 99%, Missing); midbrain: 74.2857% (minimum 99%, Missing); pituitary gland: 96.2963% (minimum 99%, Missing); retina: 14.9140% (minimum 99%, Missing); spinal cord: 87.6404% (minimum 99%, Missing)",0,1,partial,44.5,0.3,0.3,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus,ENSG00000184599,TAFA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0373418,0.012963,-0.84086
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,168.2,35.5,55.4,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (manageable, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 2); spleen: 33.7 nTPM (manageable, limit 5); lymph node: 30.1 nTPM (protected, limit 2); adrenal gland: 28.6 nTPM (vital, limit 1); thymus: 27.8 nTPM (manageable, limit 5); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); lung: 20.9 nTPM (vital, limit 1); esophagus: 18.5 nTPM (protected, limit 2); urinary bladder: 17.8 nTPM (protected, limit 2); salivary gland: 17.8 nTPM (protected, limit 2); thyroid gland: 16.7 nTPM (manageable, limit 5); colon: 16.3 nTPM (protected, limit 2); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); skin: 14.4 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 2); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 2); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000184602,SNN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 29.7845% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 45.1056% (minimum 99%, Baseline (adaptation disabled)); amygdala: 17.1533% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 12.2587% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.2662% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 20.5420% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 14.6875% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 61.6798% (minimum 99%, Baseline (adaptation disabled)); colon: 59.0452% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.7554% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.9524% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 46.0784% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 17.4074% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 30.4010% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 72.3077% (minimum 99%, Baseline (adaptation disabled)); lung: 52.9279% (minimum 99%, Baseline (adaptation disabled)); lymph node: 43.8433% (minimum 97%, Baseline (adaptation disabled)); midbrain: 17.7761% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.6677% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.9970% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.0390% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.7560% (minimum 97%, Baseline (adaptation disabled)); retina: 37.4204% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.9007% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 17.4981% (minimum 99%, Baseline (adaptation disabled)); skin: 62.0053% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.7329% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 31.1258% (minimum 99%, Baseline (adaptation disabled)); spleen: 41.0839% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.3423% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.8090% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.4577% (minimum 95%, Baseline (adaptation disabled)); tongue: 39.8305% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.9007% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,168.2,35.5,55.4,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (manageable, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 2); spleen: 33.7 nTPM (manageable, limit 5); lymph node: 30.1 nTPM (protected, limit 2); adrenal gland: 28.6 nTPM (vital, limit 1); thymus: 27.8 nTPM (manageable, limit 5); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); lung: 20.9 nTPM (vital, limit 1); esophagus: 18.5 nTPM (protected, limit 2); urinary bladder: 17.8 nTPM (protected, limit 2); salivary gland: 17.8 nTPM (protected, limit 2); thyroid gland: 16.7 nTPM (manageable, limit 5); colon: 16.3 nTPM (protected, limit 2); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); skin: 14.4 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 2); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 2); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000184602,SNN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.652155,-0.571695,-0.867413
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 29.7845% (minimum 95%, Missing); adrenal gland: 45.1056% (minimum 99%, Missing); amygdala: 17.1533% (minimum 99%, Missing); basal ganglia: 12.2587% (minimum 99%, Missing); bone marrow: 49.2662% (minimum 99%, Missing); cerebellum: 20.5420% (minimum 99%, Missing); cerebral cortex: 14.6875% (minimum 99%, Missing); choroid plexus: 61.6798% (minimum 99%, Missing); colon: 59.0452% (minimum 97%, Missing); duodenum: 72.7554% (minimum 99%, Missing); esophagus: 55.9524% (minimum 97%, Missing); heart muscle: 46.0784% (minimum 99%, Missing); hippocampal formation: 17.4074% (minimum 99%, Missing); hypothalamus: 30.4010% (minimum 99%, Missing); kidney: 62.6667% (minimum 99%, Missing); liver: 72.3077% (minimum 99%, Missing); lung: 52.9279% (minimum 99%, Missing); lymph node: 43.8433% (minimum 97%, Missing); midbrain: 17.7761% (minimum 99%, Missing); pancreas: 73.6677% (minimum 99%, Missing); parathyroid gland: 70.9970% (minimum 97%, Missing); pituitary gland: 61.0390% (minimum 99%, Missing); rectum: 80.7560% (minimum 97%, Missing); retina: 37.4204% (minimum 99%, Missing); salivary gland: 56.9007% (minimum 97%, Missing); skeletal muscle: 17.4981% (minimum 99%, Missing); skin: 62.0053% (minimum 95%, Missing); small intestine: 62.6667% (minimum 99%, Missing); smooth muscle: 69.7329% (minimum 99%, Missing); spinal cord: 31.1258% (minimum 99%, Missing); spleen: 41.0839% (minimum 95%, Missing); stomach: 63.3423% (minimum 97%, Missing); thymus: 45.8090% (minimum 95%, Missing); thyroid gland: 58.4577% (minimum 95%, Missing); tongue: 39.8305% (minimum 97%, Missing); urinary bladder: 56.9007% (minimum 97%, Missing)",0,2,partial,168.2,35.5,55.4,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (manageable, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 2); spleen: 33.7 nTPM (manageable, limit 5); lymph node: 30.1 nTPM (protected, limit 2); adrenal gland: 28.6 nTPM (vital, limit 1); thymus: 27.8 nTPM (manageable, limit 5); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); lung: 20.9 nTPM (vital, limit 1); esophagus: 18.5 nTPM (protected, limit 2); urinary bladder: 17.8 nTPM (protected, limit 2); salivary gland: 17.8 nTPM (protected, limit 2); thyroid gland: 16.7 nTPM (manageable, limit 5); colon: 16.3 nTPM (protected, limit 2); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); skin: 14.4 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 2); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 2); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000184602,SNN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.652155,-0.571695,-0.867413
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.8,4.9,6.7,"thyroid gland: 6.7 nTPM (manageable, limit 5); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 2); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184635,ZNF93,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.4865% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.6712% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.0127% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.0851% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.2941% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.7536% (minimum 99%, Baseline (adaptation disabled)); colon: 77.1084% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.0513% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.2105% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.6712% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.1905% (minimum 99%, Baseline (adaptation disabled)); liver: 86.4865% (minimum 99%, Baseline (adaptation disabled)); lung: 79.0123% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.6372% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.0851% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.0488% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.1111% (minimum 97%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.1084% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 79.0123% (minimum 99%, Baseline (adaptation disabled)); skin: 64.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.0127% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.7451% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.4865% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.0851% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.5632% (minimum 97%, Baseline (adaptation disabled)); thymus: 52.0325% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.8550% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.0127% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.3684% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.8,4.9,6.7,"thyroid gland: 6.7 nTPM (manageable, limit 5); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 2); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184635,ZNF93,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.46145,-0.403628,-0.362549
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 86.4865% (minimum 99%, Missing); amygdala: 87.6712% (minimum 99%, Missing); basal ganglia: 81.0127% (minimum 99%, Missing); bone marrow: 68.0851% (minimum 99%, Missing); cerebellum: 85.3333% (minimum 99%, Missing); cerebral cortex: 75.2941% (minimum 99%, Missing); choroid plexus: 92.7536% (minimum 99%, Missing); colon: 77.1084% (minimum 97%, Missing); duodenum: 85.3333% (minimum 99%, Missing); esophagus: 82.0513% (minimum 97%, Missing); heart muscle: 84.2105% (minimum 99%, Missing); hippocampal formation: 87.6712% (minimum 99%, Missing); hypothalamus: 85.3333% (minimum 99%, Missing); kidney: 76.1905% (minimum 99%, Missing); liver: 86.4865% (minimum 99%, Missing); lung: 79.0123% (minimum 99%, Missing); lymph node: 56.6372% (minimum 97%, Missing); midbrain: 85.3333% (minimum 99%, Missing); pancreas: 68.0851% (minimum 99%, Missing); parathyroid gland: 78.0488% (minimum 97%, Missing); pituitary gland: 85.3333% (minimum 99%, Missing); rectum: 71.1111% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 77.1084% (minimum 97%, Missing); skeletal muscle: 79.0123% (minimum 99%, Missing); skin: 64.0000% (minimum 95%, Missing); small intestine: 81.0127% (minimum 99%, Missing); smooth muscle: 62.7451% (minimum 99%, Missing); spinal cord: 86.4865% (minimum 99%, Missing); spleen: 68.0851% (minimum 95%, Missing); stomach: 73.5632% (minimum 97%, Missing); thymus: 52.0325% (minimum 95%, Missing); thyroid gland: 48.8550% (minimum 95%, Missing); tongue: 81.0127% (minimum 97%, Missing); urinary bladder: 67.3684% (minimum 97%, Missing)",0,80,unavailable,3.8,4.9,6.7,"thyroid gland: 6.7 nTPM (manageable, limit 5); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 2); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 2); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184635,ZNF93,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.46145,-0.403628,-0.362549
True,compatible,,True,True,False,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000184647,PRSS55,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.5401% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.5401% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000184647,PRSS55,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00459854
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.5401% (minimum 99%, Missing); kidney: 98.5401% (minimum 99%, Missing)",0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000184647,PRSS55,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00459854
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000184650,ODF4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000184650,ODF4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000184650,ODF4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,13,partial,6.4,5.1,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000184661,CDCA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 74.7036% (minimum 99%, Baseline (adaptation disabled)); colon: 91.3043% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.6471% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.1034% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.4375% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.7500% (minimum 97%, Baseline (adaptation disabled)); rectum: 90.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 94.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.3043% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.9391% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.9391% (minimum 97%, Baseline (adaptation disabled)); thymus: 63.0000% (minimum 95%, Baseline (adaptation disabled))",0,13,partial,6.4,5.1,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000184661,CDCA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.32,-0.1825,-0.242964
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 74.7036% (minimum 99%, Missing); colon: 91.3043% (minimum 97%, Missing); duodenum: 92.6471% (minimum 99%, Missing); esophagus: 93.1034% (minimum 97%, Missing); lymph node: 78.7500% (minimum 97%, Missing); rectum: 90.0000% (minimum 97%, Missing); skin: 94.5000% (minimum 95%, Missing); small intestine: 91.3043% (minimum 99%, Missing); stomach: 95.9391% (minimum 97%, Missing); thymus: 63.0000% (minimum 95%, Missing)",0,13,partial,6.4,5.1,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000184661,CDCA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.32,-0.1825,-0.242964
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,3.9,14.7,2.1,"tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000184675,AMER1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.9672% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.1250% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.5926% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.7193% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.9672% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.4638% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.3396% (minimum 99%, Baseline (adaptation disabled)); colon: 76.9231% (minimum 97%, Baseline (adaptation disabled)); duodenum: 78.1250% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.9351% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.3651% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.5926% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.2857% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.6269% (minimum 99%, Baseline (adaptation disabled)); liver: 70.4225% (minimum 99%, Baseline (adaptation disabled)); lung: 80.6452% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.6452% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.5926% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.4286% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.7576% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.7193% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.3651% (minimum 97%, Baseline (adaptation disabled)); retina: 80.6452% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.4225% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 56.1798% (minimum 99%, Baseline (adaptation disabled)); skin: 70.4225% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.3651% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.9351% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.3396% (minimum 99%, Baseline (adaptation disabled)); spleen: 79.3651% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.7576% (minimum 97%, Baseline (adaptation disabled)); thymus: 76.9231% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.1250% (minimum 95%, Baseline (adaptation disabled)); tongue: 25.3807% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.6452% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,3.9,14.7,2.1,"tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000184675,AMER1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.245775,-0.716193,-0.428202
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.9672% (minimum 95%, Missing); adrenal gland: 78.1250% (minimum 99%, Missing); amygdala: 92.5926% (minimum 99%, Missing); basal ganglia: 87.7193% (minimum 99%, Missing); bone marrow: 81.9672% (minimum 99%, Missing); cerebellum: 72.4638% (minimum 99%, Missing); cerebral cortex: 83.3333% (minimum 99%, Missing); choroid plexus: 94.3396% (minimum 99%, Missing); colon: 76.9231% (minimum 97%, Missing); duodenum: 78.1250% (minimum 99%, Missing); esophagus: 64.9351% (minimum 97%, Missing); heart muscle: 79.3651% (minimum 99%, Missing); hippocampal formation: 92.5926% (minimum 99%, Missing); hypothalamus: 89.2857% (minimum 99%, Missing); kidney: 74.6269% (minimum 99%, Missing); liver: 70.4225% (minimum 99%, Missing); lung: 80.6452% (minimum 99%, Missing); lymph node: 80.6452% (minimum 97%, Missing); midbrain: 92.5926% (minimum 99%, Missing); pancreas: 71.4286% (minimum 99%, Missing); parathyroid gland: 75.7576% (minimum 95%, Approved); pituitary gland: 87.7193% (minimum 99%, Missing); rectum: 79.3651% (minimum 97%, Missing); retina: 80.6452% (minimum 99%, Missing); salivary gland: 70.4225% (minimum 97%, Missing); skeletal muscle: 56.1798% (minimum 99%, Missing); skin: 70.4225% (minimum 95%, Missing); small intestine: 79.3651% (minimum 99%, Missing); smooth muscle: 64.9351% (minimum 99%, Missing); spinal cord: 94.3396% (minimum 99%, Missing); spleen: 79.3651% (minimum 95%, Missing); stomach: 75.7576% (minimum 97%, Missing); thymus: 76.9231% (minimum 95%, Missing); thyroid gland: 78.1250% (minimum 95%, Missing); tongue: 25.3807% (minimum 97%, Missing); urinary bladder: 80.6452% (minimum 97%, Missing)",0,0,routine_complete,3.9,14.7,2.1,"tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000184675,AMER1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.245775,-0.716193,-0.428202
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,14.9,0,0,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000184716,SERINC4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 92.3077% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.3077% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 25.5319% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.3077% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.3077% (minimum 99%, Baseline (adaptation disabled)); midbrain: 85.7143% (minimum 99%, Baseline (adaptation disabled)); retina: 7.4534% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.7143% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,14.9,0,0,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000184716,SERINC4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.915466
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 92.3077% (minimum 99%, Missing); basal ganglia: 92.3077% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 99%, Missing); cerebral cortex: 92.3077% (minimum 99%, Missing); choroid plexus: 25.5319% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); midbrain: 85.7143% (minimum 99%, Missing); retina: 7.4534% (minimum 99%, Missing); spinal cord: 85.7143% (minimum 99%, Missing)",0,80,unavailable,14.9,0,0,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000184716,SERINC4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.915466
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000184724,KRTAP6-1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000184724,KRTAP6-1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000184724,KRTAP6-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184735,DDX53,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184735,DDX53,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184735,DDX53,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000184786,DYNLT2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000184786,DYNLT2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,0.05,0.03,0.00438202
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000184786,DYNLT2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,0.05,0.03,0.00438202
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184814,PRR23B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184814,PRR23B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184814,PRR23B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,28.2,0.9,3.2,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184911,DMRTC1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 78.3784% (minimum 99%, Baseline (adaptation disabled)); amygdala: 29.2929% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 23.5772% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.5652% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.0663% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 27.2727% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.9231% (minimum 99%, Baseline (adaptation disabled)); colon: 90.6250% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.7528% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.7528% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 33.4615% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 24.3697% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 93.5484% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.5789% (minimum 97%, Baseline (adaptation disabled)); midbrain: 48.6034% (minimum 99%, Baseline (adaptation disabled)); pancreas: 74.3590% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.6250% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 26.1261% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 52.0958% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.5789% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.8636% (minimum 99%, Baseline (adaptation disabled)); skin: 94.5652% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.6907% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.7528% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.0476% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.6250% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.6250% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.5652% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 73.1092% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.6667% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,28.2,0.9,3.2,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184911,DMRTC1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.218908,-0.06375,-0.754228
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 78.3784% (minimum 99%, Missing); amygdala: 29.2929% (minimum 99%, Missing); basal ganglia: 23.5772% (minimum 99%, Missing); bone marrow: 94.5652% (minimum 99%, Missing); cerebellum: 48.0663% (minimum 99%, Missing); cerebral cortex: 27.2727% (minimum 99%, Missing); choroid plexus: 66.9231% (minimum 99%, Missing); colon: 90.6250% (minimum 97%, Missing); duodenum: 97.7528% (minimum 99%, Missing); heart muscle: 97.7528% (minimum 99%, Missing); hippocampal formation: 33.4615% (minimum 99%, Missing); hypothalamus: 24.3697% (minimum 99%, Missing); kidney: 87.0000% (minimum 99%, Missing); lung: 93.5484% (minimum 99%, Missing); lymph node: 91.5789% (minimum 97%, Missing); midbrain: 48.6034% (minimum 99%, Missing); pancreas: 74.3590% (minimum 99%, Missing); parathyroid gland: 90.6250% (minimum 97%, Missing); pituitary gland: 26.1261% (minimum 99%, Missing); rectum: 96.6667% (minimum 97%, Missing); retina: 52.0958% (minimum 99%, Missing); salivary gland: 91.5789% (minimum 97%, Missing); skeletal muscle: 98.8636% (minimum 99%, Missing); skin: 94.5652% (minimum 95%, Missing); small intestine: 89.6907% (minimum 99%, Missing); smooth muscle: 97.7528% (minimum 99%, Missing); spinal cord: 69.0476% (minimum 99%, Missing); spleen: 90.6250% (minimum 95%, Missing); stomach: 90.6250% (minimum 97%, Missing); thymus: 94.5652% (minimum 95%, Missing); thyroid gland: 73.1092% (minimum 95%, Missing); urinary bladder: 96.6667% (minimum 97%, Missing)",0,80,unavailable,28.2,0.9,3.2,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000184911,DMRTC1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.218908,-0.06375,-0.754228
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184933,OR6A2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184933,OR6A2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000184933,OR6A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,2,partial,4.4,6.3,0,"stomach: 6.3 nTPM (protected, limit 2); adrenal gland: 4.4 nTPM (vital, limit 2); duodenum: 2.2 nTPM (vital, limit 2); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000185002,RFX6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 16.9811% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 64.2857% (minimum 97%, Baseline (adaptation disabled)); duodenum: 29.0323% (minimum 99%, Baseline (adaptation disabled)); pancreas: 29.0323% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 42.8571% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 81.8182% (minimum 97%, Baseline (adaptation disabled)); small intestine: 42.8571% (minimum 99%, Baseline (adaptation disabled)); stomach: 12.5000% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,4.4,6.3,0,"stomach: 6.3 nTPM (protected, limit 2); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000185002,RFX6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.845,-0.820189
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 16.9811% (minimum 98%, Approved); cerebral cortex: 90.0000% (minimum 98%, Approved); colon: 64.2857% (minimum 97%, Missing); duodenum: 29.0323% (minimum 98%, Approved); pancreas: 29.0323% (minimum 99%, Missing); pituitary gland: 90.0000% (minimum 99%, Missing); rectum: 42.8571% (minimum 97%, Missing); salivary gland: 81.8182% (minimum 95%, Approved); small intestine: 42.8571% (minimum 99%, Missing); stomach: 12.5000% (minimum 97%, Missing)",0,2,partial,4.4,6.3,0,"stomach: 6.3 nTPM (protected, limit 2); adrenal gland: 4.4 nTPM (vital, limit 2); duodenum: 2.2 nTPM (vital, limit 2); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000185002,RFX6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.845,-0.810189
True,compatible,,True,True,False,,0,80,unavailable,0.7,0.9,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000185013,NT5C1B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.5714% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.8539% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.0114% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2906% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.8539% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.9,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000185013,NT5C1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.021831,0.00457627,-0.00988636
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.5714% (minimum 99%, Missing); bone marrow: 98.8539% (minimum 99%, Missing); duodenum: 98.0114% (minimum 99%, Missing); heart muscle: 98.2906% (minimum 99%, Missing); pancreas: 98.8539% (minimum 99%, Missing)",0,80,unavailable,0.7,0.9,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000185013,NT5C1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.021831,0.00457627,-0.00988636
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,10,partial,68.2,3.8,4.6,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 6); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 6); skeletal muscle: 15.8 nTPM (vital, limit 6); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185046,ANKS1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.3529% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.3069% (minimum 99%, Baseline (adaptation disabled)); amygdala: 13.5397% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 9.3085% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.5915% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 22.7273% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 9.9291% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.3077% (minimum 99%, Baseline (adaptation disabled)); colon: 64.8148% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.5946% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.6842% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 10.4012% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 15.9091% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.9469% (minimum 99%, Baseline (adaptation disabled)); liver: 86.4198% (minimum 99%, Baseline (adaptation disabled)); lung: 89.7436% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 15.4867% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.4198% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.1053% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 41.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.6076% (minimum 97%, Baseline (adaptation disabled)); retina: 54.2636% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.6842% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 30.7018% (minimum 99%, Baseline (adaptation disabled)); skin: 87.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.6517% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 10.4167% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.4198% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.3373% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.6076% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.3448% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.3529% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.7778% (minimum 97%, Baseline (adaptation disabled))",0,10,partial,68.2,3.8,4.6,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); skeletal muscle: 15.8 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); salivary gland: 2.5 nTPM (protected, limit 2); smooth muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185046,ANKS1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.346552,-0.321852,-0.896915
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.3069% (minimum 95%, Enhanced); amygdala: 13.5397% (minimum 99%, Missing); basal ganglia: 9.3085% (minimum 99%, Missing); cerebellum: 22.7273% (minimum 95%, Enhanced); cerebral cortex: 9.9291% (minimum 95%, Enhanced); choroid plexus: 67.3077% (minimum 99%, Missing); colon: 64.8148% (minimum 97%, Missing); duodenum: 94.5946% (minimum 99%, Missing); esophagus: 73.6842% (minimum 80%, Enhanced); heart muscle: 83.3333% (minimum 95%, Enhanced); hippocampal formation: 10.4012% (minimum 99%, Missing); hypothalamus: 15.9091% (minimum 99%, Missing); kidney: 61.9469% (minimum 95%, Enhanced); liver: 86.4198% (minimum 95%, Enhanced); lung: 89.7436% (minimum 95%, Enhanced); midbrain: 15.4867% (minimum 99%, Missing); pancreas: 86.4198% (minimum 95%, Enhanced); pituitary gland: 41.6667% (minimum 99%, Missing); rectum: 88.6076% (minimum 97%, Missing); retina: 54.2636% (minimum 99%, Missing); salivary gland: 73.6842% (minimum 80%, Enhanced); skeletal muscle: 30.7018% (minimum 95%, Enhanced); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 78.6517% (minimum 95%, Enhanced); spinal cord: 10.4167% (minimum 99%, Missing); thymus: 88.6076% (minimum 95%, Missing); tongue: 82.3529% (minimum 97%, Missing); urinary bladder: 77.7778% (minimum 80%, Enhanced)",0,10,partial,68.2,3.8,4.6,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 6); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 6); skeletal muscle: 15.8 nTPM (vital, limit 6); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185046,ANKS1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0639241,-0.321852,-0.896915
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12.4,0.8,1.1,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185055,EFCAB10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2877% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.0984% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.4081% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.5806% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.6190% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.0984% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.8297% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.6254% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2877% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.4013% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.6875% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.9595% (minimum 99%, Baseline (adaptation disabled)); liver: 96.6330% (minimum 99%, Baseline (adaptation disabled)); lung: 90.2516% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.2881% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.3488% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.1818% (minimum 99%, Baseline (adaptation disabled)); retina: 95.6667% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.9866% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.6190% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.9866% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,12.4,0.8,1.1,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185055,EFCAB10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0130872,0.00288136,-0.291703
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2877% (minimum 99%, Missing); amygdala: 94.0984% (minimum 99%, Missing); basal ganglia: 89.4081% (minimum 99%, Missing); bone marrow: 92.5806% (minimum 99%, Missing); cerebellum: 97.6190% (minimum 99%, Missing); cerebral cortex: 94.0984% (minimum 99%, Missing); choroid plexus: 69.8297% (minimum 99%, Missing); duodenum: 98.6254% (minimum 99%, Missing); heart muscle: 98.2877% (minimum 99%, Missing); hippocampal formation: 91.4013% (minimum 99%, Missing); hypothalamus: 89.6875% (minimum 99%, Missing); kidney: 96.9595% (minimum 99%, Missing); liver: 96.6330% (minimum 99%, Missing); lung: 90.2516% (minimum 99%, Missing); midbrain: 97.2881% (minimum 99%, Missing); pancreas: 95.3488% (minimum 99%, Missing); pituitary gland: 93.1818% (minimum 99%, Missing); retina: 95.6667% (minimum 99%, Missing); skeletal muscle: 95.9866% (minimum 99%, Missing); small intestine: 97.6190% (minimum 99%, Missing); spinal cord: 95.9866% (minimum 99%, Missing)",0,80,unavailable,12.4,0.8,1.1,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185055,EFCAB10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0130872,0.00288136,-0.291703
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000185056,C5orf47,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000185056,C5orf47,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.000566038
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000185056,C5orf47,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.000566038
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,11.8,9,4.6,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); cerebral cortex: 4.3 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000185104,FAF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 69.4118% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.4118% (minimum 99%, Baseline (adaptation disabled)); amygdala: 66.2921% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 63.4409% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.2041% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 50.4274% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.8431% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.2381% (minimum 99%, Baseline (adaptation disabled)); colon: 59.5960% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.0843% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.2041% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 47.2000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.5556% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.4409% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.2041% (minimum 99%, Baseline (adaptation disabled)); liver: 65.5556% (minimum 99%, Baseline (adaptation disabled)); lung: 67.8161% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.0455% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.6047% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.2041% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.4274% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.8161% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.1053% (minimum 97%, Baseline (adaptation disabled)); retina: 46.0938% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.2921% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 33.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 59.5960% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.6047% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.5960% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.6047% (minimum 99%, Baseline (adaptation disabled)); spleen: 71.9512% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.2381% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.1905% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.1905% (minimum 95%, Baseline (adaptation disabled)); tongue: 39.5973% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.1304% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,11.8,9,4.6,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); cerebral cortex: 4.3 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000185104,FAF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.388095,-0.574027,-0.656667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 69.4118% (minimum 95%, Missing); adrenal gland: 69.4118% (minimum 99%, Missing); amygdala: 66.2921% (minimum 99%, Missing); basal ganglia: 63.4409% (minimum 99%, Missing); bone marrow: 60.2041% (minimum 99%, Missing); cerebellum: 50.4274% (minimum 99%, Missing); cerebral cortex: 57.8431% (minimum 99%, Missing); choroid plexus: 70.2381% (minimum 99%, Missing); colon: 59.5960% (minimum 97%, Missing); duodenum: 71.0843% (minimum 99%, Missing); esophagus: 60.2041% (minimum 97%, Missing); heart muscle: 47.2000% (minimum 99%, Missing); hippocampal formation: 65.5556% (minimum 99%, Missing); hypothalamus: 63.4409% (minimum 99%, Missing); kidney: 60.2041% (minimum 99%, Missing); liver: 65.5556% (minimum 98%, Approved); lung: 67.8161% (minimum 99%, Missing); lymph node: 67.0455% (minimum 97%, Missing); midbrain: 68.6047% (minimum 99%, Missing); pancreas: 60.2041% (minimum 99%, Missing); parathyroid gland: 50.4274% (minimum 97%, Missing); pituitary gland: 67.8161% (minimum 99%, Missing); rectum: 62.1053% (minimum 97%, Missing); retina: 46.0938% (minimum 99%, Missing); salivary gland: 66.2921% (minimum 97%, Missing); skeletal muscle: 33.3333% (minimum 99%, Missing); skin: 59.5960% (minimum 95%, Missing); small intestine: 68.6047% (minimum 99%, Missing); smooth muscle: 59.5960% (minimum 99%, Missing); spinal cord: 68.6047% (minimum 99%, Missing); spleen: 71.9512% (minimum 95%, Missing); stomach: 70.2381% (minimum 97%, Missing); thymus: 56.1905% (minimum 95%, Missing); thyroid gland: 56.1905% (minimum 95%, Missing); tongue: 39.5973% (minimum 97%, Missing); urinary bladder: 64.1304% (minimum 97%, Missing)",0,8,partial,11.8,9,4.6,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 2); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 2); cerebral cortex: 4.3 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); smooth muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); lymph node: 2.9 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000185104,FAF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.388095,-0.574027,-0.656667
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.1,6.6,3.3,"pancreas: 9.1 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); pituitary gland: 4.7 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); stomach: 3.9 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185156,MFSD6L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 90.5109% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.5129% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.9394% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8048% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.1563% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.1111% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.0678% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.2086% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 78.9809% (minimum 97%, Baseline (adaptation disabled)); small intestine: 94.2966% (minimum 99%, Baseline (adaptation disabled)); stomach: 86.4111% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 88.2562% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,9.1,6.6,3.3,"pancreas: 9.1 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); pituitary gland: 4.7 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); stomach: 3.9 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185156,MFSD6L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0674377,-0.180191,-0.258437
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 90.5109% (minimum 97%, Missing); duodenum: 91.5129% (minimum 99%, Missing); kidney: 93.9394% (minimum 99%, Missing); lung: 98.8048% (minimum 99%, Missing); pancreas: 73.1563% (minimum 99%, Missing); parathyroid gland: 86.1111% (minimum 97%, Missing); pituitary gland: 84.0678% (minimum 99%, Missing); rectum: 89.2086% (minimum 97%, Missing); salivary gland: 78.9809% (minimum 97%, Missing); small intestine: 94.2966% (minimum 99%, Missing); stomach: 86.4111% (minimum 97%, Missing); thyroid gland: 88.2562% (minimum 95%, Missing)",0,80,unavailable,9.1,6.6,3.3,"pancreas: 9.1 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 2); pituitary gland: 4.7 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); stomach: 3.9 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185156,MFSD6L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0674377,-0.180191,-0.258437
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000185177,ZNF479,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.4286% (minimum 99%, Baseline (adaptation disabled)); retina: 96.4286% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000185177,ZNF479,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0142857,0.03,-0.0257143
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.4286% (minimum 99%, Missing); retina: 96.4286% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000185177,ZNF479,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0142857,0.03,-0.0257143
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,163.8,114.6,203.6,"thyroid gland: 203.6 nTPM (manageable, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); spleen: 115.8 nTPM (manageable, limit 5); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 2); pituitary gland: 112.7 nTPM (vital, limit 1); salivary gland: 101.2 nTPM (protected, limit 2); adipose tissue: 98.8 nTPM (manageable, limit 5); skin: 98.6 nTPM (manageable, limit 5); urinary bladder: 96.2 nTPM (protected, limit 2); colon: 95.8 nTPM (protected, limit 2); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 2); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); lymph node: 57.3 nTPM (protected, limit 2); parathyroid gland: 47.2 nTPM (protected, limit 2); thymus: 42.9 nTPM (manageable, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 2); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185236,RAB11B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.7046% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.0236% (minimum 99%, Baseline (adaptation disabled)); amygdala: 47.0714% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 44.4131% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.9235% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 44.2524% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 44.2524% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.0946% (minimum 99%, Baseline (adaptation disabled)); colon: 53.4726% (minimum 97%, Baseline (adaptation disabled)); duodenum: 59.7072% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.3435% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 40.3740% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 45.5712% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 47.2938% (minimum 99%, Baseline (adaptation disabled)); kidney: 46.6921% (minimum 99%, Baseline (adaptation disabled)); liver: 45.7416% (minimum 99%, Baseline (adaptation disabled)); lung: 53.6288% (minimum 99%, Baseline (adaptation disabled)); lymph node: 65.7706% (minimum 97%, Baseline (adaptation disabled)); midbrain: 43.3124% (minimum 99%, Baseline (adaptation disabled)); pancreas: 46.6328% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.9936% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 49.4165% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.9691% (minimum 97%, Baseline (adaptation disabled)); retina: 74.8470% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 52.1060% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 48.8248% (minimum 99%, Baseline (adaptation disabled)); skin: 52.7552% (minimum 95%, Baseline (adaptation disabled)); small intestine: 53.8123% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.4237% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 40.1972% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.7384% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.9987% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.9608% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 35.0972% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.6701% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.3689% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,163.8,114.6,203.6,"thyroid gland: 203.6 nTPM (manageable, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); spleen: 115.8 nTPM (manageable, limit 5); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 2); pituitary gland: 112.7 nTPM (vital, limit 1); salivary gland: 101.2 nTPM (protected, limit 2); adipose tissue: 98.8 nTPM (manageable, limit 5); skin: 98.6 nTPM (manageable, limit 5); urinary bladder: 96.2 nTPM (protected, limit 2); colon: 95.8 nTPM (protected, limit 2); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 2); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); lymph node: 57.3 nTPM (protected, limit 2); parathyroid gland: 47.2 nTPM (protected, limit 2); thymus: 42.9 nTPM (manageable, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 2); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185236,RAB11B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.599028,-0.480013,-0.588028
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.7046% (minimum 95%, Missing); adrenal gland: 54.0236% (minimum 99%, Missing); amygdala: 47.0714% (minimum 99%, Missing); basal ganglia: 44.4131% (minimum 99%, Missing); bone marrow: 61.9235% (minimum 99%, Missing); cerebellum: 44.2524% (minimum 99%, Missing); cerebral cortex: 44.2524% (minimum 99%, Missing); choroid plexus: 63.0946% (minimum 99%, Missing); colon: 53.4726% (minimum 97%, Missing); duodenum: 59.7072% (minimum 99%, Missing); esophagus: 54.3435% (minimum 97%, Missing); heart muscle: 40.3740% (minimum 99%, Missing); hippocampal formation: 45.5712% (minimum 99%, Missing); hypothalamus: 47.2938% (minimum 99%, Missing); kidney: 46.6921% (minimum 99%, Missing); liver: 45.7416% (minimum 99%, Missing); lung: 53.6288% (minimum 99%, Missing); lymph node: 65.7706% (minimum 97%, Missing); midbrain: 43.3124% (minimum 99%, Missing); pancreas: 46.6328% (minimum 99%, Missing); parathyroid gland: 69.9936% (minimum 97%, Missing); pituitary gland: 49.4165% (minimum 99%, Missing); rectum: 82.9691% (minimum 97%, Missing); retina: 74.8470% (minimum 99%, Missing); salivary gland: 52.1060% (minimum 97%, Missing); skeletal muscle: 48.8248% (minimum 99%, Missing); skin: 52.7552% (minimum 95%, Missing); small intestine: 53.8123% (minimum 99%, Missing); smooth muscle: 80.4237% (minimum 99%, Missing); spinal cord: 40.1972% (minimum 99%, Missing); spleen: 48.7384% (minimum 95%, Missing); stomach: 48.9987% (minimum 97%, Missing); thymus: 71.9608% (minimum 95%, Missing); thyroid gland: 35.0972% (minimum 95%, Missing); tongue: 75.6701% (minimum 97%, Missing); urinary bladder: 53.3689% (minimum 97%, Missing)",0,80,unavailable,163.8,114.6,203.6,"thyroid gland: 203.6 nTPM (manageable, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); spleen: 115.8 nTPM (manageable, limit 5); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 2); pituitary gland: 112.7 nTPM (vital, limit 1); salivary gland: 101.2 nTPM (protected, limit 2); adipose tissue: 98.8 nTPM (manageable, limit 5); skin: 98.6 nTPM (manageable, limit 5); urinary bladder: 96.2 nTPM (protected, limit 2); colon: 95.8 nTPM (protected, limit 2); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 2); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); lymph node: 57.3 nTPM (protected, limit 2); parathyroid gland: 47.2 nTPM (protected, limit 2); thymus: 42.9 nTPM (manageable, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 2); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185236,RAB11B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.599028,-0.480013,-0.588028
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,0,routine_complete,4.9,14.3,3.6,"lymph node: 14.3 nTPM (protected, limit 6); bone marrow: 4.9 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000185245,GP1BA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 42.8571% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 5.7692% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 50.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 37.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 42.8571% (minimum 97%, Baseline (adaptation disabled)); duodenum: 20.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 50.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 37.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 42.8571% (minimum 99%, Baseline (adaptation disabled)); liver: 42.8571% (minimum 99%, Baseline (adaptation disabled)); lung: 20.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 2.0548% (minimum 97%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 42.8571% (minimum 97%, Baseline (adaptation disabled)); retina: 11.5385% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 25.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 10.3448% (minimum 99%, Baseline (adaptation disabled)); skin: 11.5385% (minimum 95%, Baseline (adaptation disabled)); small intestine: 20.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 7.6923% (minimum 95%, Baseline (adaptation disabled)); stomach: 30.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 33.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,4.9,14.3,3.6,"lymph node: 14.3 nTPM (protected, limit 2); bone marrow: 4.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000185245,GP1BA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.873077,-0.949452,-0.932308
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 42.8571% (minimum 80%, Supported); adrenal gland: 75.0000% (minimum 97%, Supported); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 60.0000% (minimum 99%, Missing); bone marrow: 5.7692% (minimum 99%, Missing); cerebellum: 50.0000% (minimum 97%, Supported); cerebral cortex: 37.5000% (minimum 97%, Supported); colon: 42.8571% (minimum 90%, Supported); duodenum: 20.0000% (minimum 97%, Supported); esophagus: 50.0000% (minimum 90%, Supported); heart muscle: 37.5000% (minimum 97%, Supported); hippocampal formation: 75.0000% (minimum 99%, Missing); kidney: 42.8571% (minimum 97%, Supported); liver: 42.8571% (minimum 97%, Supported); lung: 20.0000% (minimum 97%, Supported); lymph node: 2.0548% (minimum 90%, Supported); pancreas: 75.0000% (minimum 97%, Supported); rectum: 42.8571% (minimum 90%, Supported); retina: 11.5385% (minimum 99%, Missing); salivary gland: 25.0000% (minimum 90%, Supported); skeletal muscle: 10.3448% (minimum 97%, Supported); skin: 11.5385% (minimum 80%, Supported); small intestine: 20.0000% (minimum 97%, Supported); spleen: 7.6923% (minimum 95%, Missing); stomach: 30.0000% (minimum 90%, Supported); thymus: 33.3333% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 80%, Supported); urinary bladder: 75.0000% (minimum 90%, Supported)",0,0,routine_complete,4.9,14.3,3.6,"lymph node: 14.3 nTPM (protected, limit 6); bone marrow: 4.9 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000185245,GP1BA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.873077,-0.879452,-0.932308
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,ENSG00000185247,MAGEA11,reproductive_required,False,True,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,ENSG00000185247,MAGEA11,current_fixed,False,True,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.0251456,0.00514563
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,ENSG00000185247,MAGEA11,current_adaptive,False,True,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.0251456,0.00514563
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,3.2,1.3,1.7,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000185261,KIAA0825,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.9730% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.3636% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 71.0526% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.7907% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.7907% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.8182% (minimum 99%, Baseline (adaptation disabled)); colon: 81.8182% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.3750% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.9730% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.1429% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 72.9730% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.1429% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.1429% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 67.5000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.9730% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.8182% (minimum 97%, Baseline (adaptation disabled)); retina: 45.7627% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.4118% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.8537% (minimum 99%, Baseline (adaptation disabled)); skin: 77.1429% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.3750% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 77.1429% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.1429% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.8182% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.3636% (minimum 95%, Baseline (adaptation disabled)); tongue: 72.9730% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.0526% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,3.2,1.3,1.7,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000185261,KIAA0825,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.336364,-0.295,-0.532373
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Uncertain); adrenal gland: 72.9730% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 61.3636% (minimum 99%, Missing); bone marrow: 71.0526% (minimum 99%, Uncertain); cerebellum: 62.7907% (minimum 99%, Missing); cerebral cortex: 62.7907% (minimum 99%, Missing); choroid plexus: 81.8182% (minimum 99%, Missing); colon: 81.8182% (minimum 97%, Missing); duodenum: 84.3750% (minimum 99%, Missing); esophagus: 72.9730% (minimum 97%, Missing); heart muscle: 77.1429% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 67.5000% (minimum 99%, Missing); liver: 72.9730% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 77.1429% (minimum 97%, Missing); midbrain: 90.0000% (minimum 99%, Missing); pancreas: 77.1429% (minimum 99%, Missing); parathyroid gland: 67.5000% (minimum 97%, Missing); pituitary gland: 72.9730% (minimum 99%, Missing); rectum: 81.8182% (minimum 97%, Missing); retina: 45.7627% (minimum 99%, Missing); salivary gland: 79.4118% (minimum 97%, Missing); skeletal muscle: 65.8537% (minimum 99%, Missing); skin: 77.1429% (minimum 95%, Missing); small intestine: 84.3750% (minimum 99%, Missing); smooth muscle: 77.1429% (minimum 99%, Missing); spinal cord: 90.0000% (minimum 99%, Missing); spleen: 77.1429% (minimum 95%, Uncertain); stomach: 81.8182% (minimum 97%, Missing); thymus: 75.0000% (minimum 95%, Missing); thyroid gland: 61.3636% (minimum 95%, Missing); tongue: 72.9730% (minimum 97%, Missing); urinary bladder: 71.0526% (minimum 97%, Uncertain)",0,3,partial,3.2,1.3,1.7,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000185261,KIAA0825,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.336364,-0.295,-0.532373
True,compatible,,True,True,False,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000185264,TEX33,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000185264,TEX33,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.0088764
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000185264,TEX33,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.7,2,2.1,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000185269,NOTUM,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 93.1059% (minimum 99%, Baseline (adaptation disabled)); lung: 98.4222% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 94.3125% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,9.7,2,2.1,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000185269,NOTUM,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0342224,0.0149624,-0.058941
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 93.1059% (minimum 99%, Missing); lung: 98.4222% (minimum 99%, Missing); skeletal muscle: 94.3125% (minimum 99%, Missing)",0,80,unavailable,9.7,2,2.1,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000185269,NOTUM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0342224,0.0149624,-0.058941
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,10.2,3.4,3.5,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185278,ZBTB37,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.7748% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.8384% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.8384% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.4815% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.5825% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.2222% (minimum 99%, Baseline (adaptation disabled)); colon: 82.1782% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.5670% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.4583% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.5825% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.3725% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.5670% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.3725% (minimum 99%, Baseline (adaptation disabled)); liver: 82.1782% (minimum 99%, Baseline (adaptation disabled)); lung: 76.1468% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.9402% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.8077% (minimum 99%, Baseline (adaptation disabled)); pancreas: 83.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.8519% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.6939% (minimum 97%, Baseline (adaptation disabled)); retina: 44.8649% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 81.3725% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 73.4513% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.0476% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.8384% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.4545% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.3390% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.1782% (minimum 97%, Baseline (adaptation disabled)); thymus: 73.4513% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 76.8519% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.8077% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 81.3725% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,10.2,3.4,3.5,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185278,ZBTB37,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.24661,-0.260598,-0.541351
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.7748% (minimum 95%, Missing); adrenal gland: 83.8384% (minimum 99%, Missing); amygdala: 83.8384% (minimum 99%, Missing); basal ganglia: 83.0000% (minimum 99%, Missing); bone marrow: 61.4815% (minimum 99%, Missing); cerebellum: 83.0000% (minimum 99%, Missing); cerebral cortex: 80.5825% (minimum 99%, Missing); choroid plexus: 92.2222% (minimum 99%, Missing); colon: 82.1782% (minimum 97%, Missing); duodenum: 85.5670% (minimum 99%, Missing); esophagus: 86.4583% (minimum 97%, Missing); heart muscle: 80.5825% (minimum 99%, Missing); hippocampal formation: 81.3725% (minimum 99%, Missing); hypothalamus: 85.5670% (minimum 99%, Missing); kidney: 81.3725% (minimum 99%, Missing); liver: 82.1782% (minimum 99%, Missing); lung: 76.1468% (minimum 99%, Missing); lymph node: 70.9402% (minimum 97%, Missing); midbrain: 79.8077% (minimum 99%, Missing); pancreas: 83.0000% (minimum 99%, Missing); parathyroid gland: 83.0000% (minimum 97%, Missing); pituitary gland: 76.8519% (minimum 99%, Missing); rectum: 84.6939% (minimum 97%, Missing); retina: 44.8649% (minimum 99%, Missing); salivary gland: 81.3725% (minimum 97%, Missing); skeletal muscle: 83.0000% (minimum 99%, Missing); skin: 73.4513% (minimum 95%, Missing); small intestine: 79.0476% (minimum 99%, Missing); smooth muscle: 83.8384% (minimum 99%, Missing); spinal cord: 75.4545% (minimum 99%, Missing); spleen: 70.3390% (minimum 95%, Missing); stomach: 82.1782% (minimum 97%, Missing); thymus: 73.4513% (minimum 95%, Missing); thyroid gland: 76.8519% (minimum 95%, Missing); tongue: 79.8077% (minimum 97%, Missing); urinary bladder: 81.3725% (minimum 97%, Missing)",0,1,partial,10.2,3.4,3.5,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); tongue: 2.1 nTPM (protected, limit 2); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185278,ZBTB37,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.24661,-0.260598,-0.541351
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,17.7,7.5,15,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 2); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185290,NUPR2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.0114% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2067% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2346% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.5714% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5996% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.1199% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.9106% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.5305% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,17.7,7.5,15,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 2); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185290,NUPR2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.00833333,0.0087234,-0.0388007
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.0114% (minimum 99%, Missing); basal ganglia: 98.2067% (minimum 99%, Missing); cerebellum: 98.2346% (minimum 99%, Missing); cerebral cortex: 98.5714% (minimum 99%, Missing); hypothalamus: 98.5996% (minimum 99%, Missing); kidney: 95.1199% (minimum 99%, Missing); pancreas: 98.9106% (minimum 99%, Missing); pituitary gland: 96.5305% (minimum 99%, Missing)",0,80,unavailable,17.7,7.5,15,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 2); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185290,NUPR2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.00833333,0.0087234,-0.0388007
True,compatible,,True,True,False,,0,5,partial,1.7,0,0,,,49,not_established,not_triggered,,,ENSG00000185294,SPPL2C,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 95.4667% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.8950% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,1.7,0,0,"cerebellum: 1.7 nTPM (vital, limit 1)",,49,not_established,not_triggered,,,ENSG00000185294,SPPL2C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0353333
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 95.4667% (minimum 97%, Supported); pituitary gland: 98.8950% (minimum 99%, Missing)",0,5,partial,1.7,0,0,,,49,not_established,not_triggered,,,ENSG00000185294,SPPL2C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0153333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,2.4,0.9,1.8,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,ENSG00000185306,C12orf56,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.6486% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.6486% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.0526% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.2577% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.0244% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 98.6486% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.6486% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.3333% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.6486% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.6486% (minimum 99%, Baseline (adaptation disabled)); retina: 83.9080% (minimum 99%, Baseline (adaptation disabled)); skin: 91.2500% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 97.3333% (minimum 99%, Baseline (adaptation disabled)); thymus: 80.2198% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,2.4,0.9,1.8,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,ENSG00000185306,C12orf56,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.147802,-0.0797561,-0.237423
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.6486% (minimum 99%, Missing); basal ganglia: 98.6486% (minimum 99%, Missing); choroid plexus: 75.2577% (minimum 99%, Missing); hippocampal formation: 98.6486% (minimum 99%, Missing); hypothalamus: 98.6486% (minimum 99%, Missing); midbrain: 98.6486% (minimum 99%, Missing); pituitary gland: 98.6486% (minimum 99%, Missing); retina: 83.9080% (minimum 99%, Missing); spinal cord: 97.3333% (minimum 99%, Missing); thymus: 80.2198% (minimum 95%, Missing)",0,2,partial,2.4,0.9,1.8,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,ENSG00000185306,C12orf56,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.147802,0.03,-0.237423
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000185313,SCN10A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"heart muscle: 50.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000185313,SCN10A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.49
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"heart muscle: 50.0000% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000185313,SCN10A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.49
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,16.7,2.6,2.3,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,ENSG00000185352,HS6ST3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6061% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 32.7869% (minimum 99%, Baseline (adaptation disabled)); amygdala: 27.7778% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 25.3165% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.1429% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 10.6952% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.9231% (minimum 99%, Baseline (adaptation disabled)); colon: 90.9091% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.9565% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.9655% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 15.5039% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 22.9885% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.4286% (minimum 99%, Baseline (adaptation disabled)); midbrain: 40.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 48.7805% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 51.2821% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.2381% (minimum 97%, Baseline (adaptation disabled)); retina: 47.6190% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.9565% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.1429% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.1429% (minimum 99%, Baseline (adaptation disabled)); stomach: 71.4286% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 46.5116% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 43.4783% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,16.7,2.6,2.3,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,ENSG00000185352,HS6ST3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.484884,-0.535217,-0.883048
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6061% (minimum 95%, Missing); adrenal gland: 32.7869% (minimum 99%, Missing); amygdala: 27.7778% (minimum 99%, Missing); basal ganglia: 25.3165% (minimum 99%, Missing); cerebellum: 57.1429% (minimum 99%, Missing); cerebral cortex: 10.6952% (minimum 99%, Missing); choroid plexus: 76.9231% (minimum 99%, Missing); colon: 90.9091% (minimum 97%, Missing); duodenum: 86.9565% (minimum 99%, Missing); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 68.9655% (minimum 99%, Missing); hippocampal formation: 15.5039% (minimum 99%, Missing); hypothalamus: 22.9885% (minimum 99%, Missing); kidney: 71.4286% (minimum 99%, Missing); midbrain: 40.0000% (minimum 99%, Missing); pancreas: 48.7805% (minimum 99%, Missing); parathyroid gland: 50.0000% (minimum 97%, Missing); pituitary gland: 51.2821% (minimum 99%, Missing); rectum: 95.2381% (minimum 97%, Missing); retina: 47.6190% (minimum 99%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 86.9565% (minimum 99%, Missing); smooth muscle: 57.1429% (minimum 99%, Missing); spinal cord: 57.1429% (minimum 99%, Missing); stomach: 71.4286% (minimum 97%, Missing); thyroid gland: 46.5116% (minimum 95%, Missing); urinary bladder: 43.4783% (minimum 97%, Missing)",0,80,unavailable,16.7,2.6,2.3,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,ENSG00000185352,HS6ST3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.484884,-0.535217,-0.883048
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,28.5,20.2,10.3,"skeletal muscle: 28.5 nTPM (vital, limit 2); tongue: 20.2 nTPM (protected, limit 2); heart muscle: 16.2 nTPM (vital, limit 2); esophagus: 14.2 nTPM (protected, limit 2); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 2); spinal cord: 12.1 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 2); salivary gland: 9.6 nTPM (protected, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 4); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); small intestine: 7.8 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.1 nTPM (protected, limit 2); pituitary gland: 7 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 2); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); smooth muscle: 5.1 nTPM (vital, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185414,MRPL30,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.5155% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 44.7489% (minimum 99%, Baseline (adaptation disabled)); amygdala: 47.5728% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 51.3089% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 74.8092% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 49.7462% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 44.3439% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.2424% (minimum 99%, Baseline (adaptation disabled)); colon: 50.7772% (minimum 97%, Baseline (adaptation disabled)); duodenum: 59.0361% (minimum 99%, Baseline (adaptation disabled)); esophagus: 40.8333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 37.6923% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.5155% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 46.4455% (minimum 99%, Baseline (adaptation disabled)); kidney: 44.7489% (minimum 99%, Baseline (adaptation disabled)); liver: 42.4242% (minimum 99%, Baseline (adaptation disabled)); lung: 62.8205% (minimum 99%, Baseline (adaptation disabled)); lymph node: 65.7718% (minimum 97%, Baseline (adaptation disabled)); midbrain: 48.2759% (minimum 99%, Baseline (adaptation disabled)); pancreas: 47.3430% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.9882% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.1227% (minimum 97%, Baseline (adaptation disabled)); retina: 62.8205% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.5155% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 25.5875% (minimum 99%, Baseline (adaptation disabled)); skin: 48.7562% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.6818% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.7718% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 44.7489% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.6826% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.6471% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.0361% (minimum 95%, Baseline (adaptation disabled)); tongue: 32.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.1277% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,28.5,20.2,10.3,"skeletal muscle: 28.5 nTPM (vital, limit 1); tongue: 20.2 nTPM (protected, limit 2); heart muscle: 16.2 nTPM (vital, limit 1); esophagus: 14.2 nTPM (protected, limit 2); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); spinal cord: 12.1 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 2); salivary gland: 9.6 nTPM (protected, limit 2); adipose tissue: 9.6 nTPM (manageable, limit 5); hippocampal formation: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 2); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); small intestine: 7.8 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.1 nTPM (protected, limit 2); pituitary gland: 7 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 2); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); smooth muscle: 5.1 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185414,MRPL30,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.462438,-0.643333,-0.734125
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.5155% (minimum 90%, Approved); adrenal gland: 44.7489% (minimum 98%, Approved); amygdala: 47.5728% (minimum 99%, Missing); basal ganglia: 51.3089% (minimum 99%, Missing); bone marrow: 74.8092% (minimum 99%, Missing); cerebellum: 49.7462% (minimum 99%, Missing); cerebral cortex: 44.3439% (minimum 99%, Missing); choroid plexus: 74.2424% (minimum 99%, Missing); colon: 50.7772% (minimum 95%, Approved); duodenum: 59.0361% (minimum 99%, Missing); esophagus: 40.8333% (minimum 97%, Missing); heart muscle: 37.6923% (minimum 98%, Approved); hippocampal formation: 50.5155% (minimum 99%, Missing); hypothalamus: 46.4455% (minimum 99%, Missing); kidney: 44.7489% (minimum 99%, Missing); liver: 42.4242% (minimum 99%, Missing); lung: 62.8205% (minimum 99%, Missing); lymph node: 65.7718% (minimum 97%, Missing); midbrain: 48.2759% (minimum 99%, Missing); pancreas: 47.3430% (minimum 99%, Missing); parathyroid gland: 57.9882% (minimum 97%, Missing); pituitary gland: 58.3333% (minimum 99%, Missing); rectum: 60.1227% (minimum 97%, Missing); retina: 62.8205% (minimum 99%, Missing); salivary gland: 50.5155% (minimum 97%, Missing); skeletal muscle: 25.5875% (minimum 98%, Approved); skin: 48.7562% (minimum 95%, Missing); small intestine: 55.6818% (minimum 99%, Missing); smooth muscle: 65.7718% (minimum 98%, Approved); spinal cord: 44.7489% (minimum 99%, Missing); spleen: 58.6826% (minimum 95%, Missing); stomach: 50.0000% (minimum 97%, Missing); thymus: 57.6471% (minimum 95%, Missing); thyroid gland: 59.0361% (minimum 95%, Missing); tongue: 32.6667% (minimum 97%, Missing); urinary bladder: 52.1277% (minimum 97%, Missing)",0,7,partial,28.5,20.2,10.3,"skeletal muscle: 28.5 nTPM (vital, limit 2); tongue: 20.2 nTPM (protected, limit 2); heart muscle: 16.2 nTPM (vital, limit 2); esophagus: 14.2 nTPM (protected, limit 2); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 2); spinal cord: 12.1 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 2); salivary gland: 9.6 nTPM (protected, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 4); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 2); small intestine: 7.8 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.1 nTPM (protected, limit 2); pituitary gland: 7 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 2); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); smooth muscle: 5.1 nTPM (vital, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185414,MRPL30,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.462438,-0.643333,-0.724125
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000185448,FAM47A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000185448,FAM47A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000185448,FAM47A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,8,partial,9.2,4.1,7.4,"bone marrow: 9.2 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); lymph node: 4.1 nTPM (protected, limit 4); rectum: 3.7 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000185480,PARPBP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.6087% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.3636% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.6829% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.6829% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 29.2308% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.4762% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.3636% (minimum 99%, Baseline (adaptation disabled)); colon: 56.7164% (minimum 97%, Baseline (adaptation disabled)); duodenum: 63.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.0548% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.6829% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.6829% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.5510% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.6087% (minimum 99%, Baseline (adaptation disabled)); liver: 86.3636% (minimum 99%, Baseline (adaptation disabled)); lung: 86.3636% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.1013% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.3721% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.6829% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.6829% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 50.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 95.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.8511% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.6829% (minimum 99%, Baseline (adaptation disabled)); skin: 66.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 58.4615% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.3704% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.4762% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.8571% (minimum 97%, Baseline (adaptation disabled)); thymus: 33.9286% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.3721% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.4762% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.8571% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,9.2,4.1,7.4,"bone marrow: 9.2 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); lymph node: 4.1 nTPM (protected, limit 2); rectum: 3.7 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000185480,PARPBP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.610714,-0.488987,-0.697692
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.6087% (minimum 90%, Approved); adrenal gland: 86.3636% (minimum 99%, Missing); amygdala: 92.6829% (minimum 99%, Missing); basal ganglia: 92.6829% (minimum 99%, Missing); bone marrow: 29.2308% (minimum 99%, Missing); cerebellum: 90.4762% (minimum 99%, Missing); cerebral cortex: 86.3636% (minimum 99%, Missing); colon: 56.7164% (minimum 97%, Missing); duodenum: 63.3333% (minimum 98%, Approved); esophagus: 52.0548% (minimum 97%, Missing); heart muscle: 92.6829% (minimum 99%, Missing); hippocampal formation: 92.6829% (minimum 99%, Missing); hypothalamus: 77.5510% (minimum 99%, Missing); kidney: 82.6087% (minimum 99%, Missing); liver: 86.3636% (minimum 98%, Approved); lung: 86.3636% (minimum 99%, Missing); lymph node: 48.1013% (minimum 95%, Approved); midbrain: 88.3721% (minimum 99%, Missing); pancreas: 92.6829% (minimum 99%, Missing); parathyroid gland: 92.6829% (minimum 97%, Missing); pituitary gland: 95.0000% (minimum 99%, Missing); rectum: 50.6667% (minimum 97%, Missing); retina: 95.0000% (minimum 99%, Missing); salivary gland: 80.8511% (minimum 97%, Missing); skeletal muscle: 92.6829% (minimum 99%, Missing); skin: 66.6667% (minimum 95%, Missing); small intestine: 58.4615% (minimum 99%, Missing); smooth muscle: 70.3704% (minimum 99%, Missing); spinal cord: 90.4762% (minimum 99%, Missing); spleen: 76.0000% (minimum 90%, Approved); stomach: 67.8571% (minimum 97%, Missing); thymus: 33.9286% (minimum 95%, Missing); thyroid gland: 88.3721% (minimum 95%, Missing); tongue: 90.4762% (minimum 97%, Missing); urinary bladder: 67.8571% (minimum 97%, Missing)",0,8,partial,9.2,4.1,7.4,"bone marrow: 9.2 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); lymph node: 4.1 nTPM (protected, limit 4); rectum: 3.7 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); colon: 2.9 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000185480,PARPBP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.610714,-0.468987,-0.697692
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,0.8,0.5,"pancreas: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000185523,SPATA45,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2906% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2906% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.4576% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2906% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2906% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.2906% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.4576% (minimum 99%, Baseline (adaptation disabled)); liver: 96.6387% (minimum 99%, Baseline (adaptation disabled)); lung: 96.6387% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.4959% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.2906% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.8611% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.4576% (minimum 99%, Baseline (adaptation disabled)); retina: 95.8333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.8333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4576% (minimum 99%, Baseline (adaptation disabled)); tongue: 95.8333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,0.8,0.5,"pancreas: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000185523,SPATA45,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00833333,-0.0350407,-0.191389
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2906% (minimum 99%, Missing); basal ganglia: 98.2906% (minimum 99%, Missing); bone marrow: 97.4576% (minimum 99%, Missing); cerebral cortex: 98.2906% (minimum 99%, Missing); hippocampal formation: 98.2906% (minimum 99%, Missing); hypothalamus: 98.2906% (minimum 99%, Missing); kidney: 97.4576% (minimum 99%, Missing); liver: 96.6387% (minimum 99%, Missing); lung: 96.6387% (minimum 99%, Missing); lymph node: 93.4959% (minimum 97%, Missing); midbrain: 98.2906% (minimum 99%, Missing); pancreas: 79.8611% (minimum 99%, Missing); pituitary gland: 97.4576% (minimum 99%, Missing); retina: 95.8333% (minimum 99%, Missing); smooth muscle: 95.8333% (minimum 99%, Missing); spinal cord: 97.4576% (minimum 99%, Missing); tongue: 95.8333% (minimum 97%, Missing)",0,80,unavailable,2.9,0.8,0.5,"pancreas: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000185523,SPATA45,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00833333,-0.0350407,-0.191389
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,15.4,2.7,0.6,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185634,SHC4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.8919% (minimum 99%, Baseline (adaptation disabled)); amygdala: 54.5455% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 50.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.6271% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.4737% (minimum 99%, Baseline (adaptation disabled)); colon: 79.0698% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.1429% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.3271% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.1194% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 48.5714% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.5767% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.1429% (minimum 99%, Baseline (adaptation disabled)); lung: 97.1429% (minimum 99%, Baseline (adaptation disabled)); midbrain: 44.9339% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0769% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.0714% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.3271% (minimum 97%, Baseline (adaptation disabled)); retina: 92.7273% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.6066% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.8919% (minimum 99%, Baseline (adaptation disabled)); skin: 94.4444% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.5780% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.5780% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 39.8437% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.4444% (minimum 97%, Baseline (adaptation disabled)); tongue: 90.2655% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.2264% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,15.4,2.7,0.6,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185634,SHC4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.00555556,-0.179302,-0.591562
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 91.8919% (minimum 99%, Missing); amygdala: 54.5455% (minimum 99%, Missing); basal ganglia: 50.0000% (minimum 99%, Missing); cerebellum: 85.0000% (minimum 99%, Missing); cerebral cortex: 57.6271% (minimum 99%, Missing); choroid plexus: 89.4737% (minimum 99%, Missing); colon: 79.0698% (minimum 97%, Missing); duodenum: 97.1429% (minimum 99%, Missing); esophagus: 95.3271% (minimum 97%, Missing); heart muscle: 76.1194% (minimum 99%, Missing); hippocampal formation: 48.5714% (minimum 99%, Missing); hypothalamus: 62.5767% (minimum 99%, Missing); kidney: 97.1429% (minimum 99%, Missing); lung: 97.1429% (minimum 99%, Missing); midbrain: 44.9339% (minimum 99%, Missing); pancreas: 98.0769% (minimum 99%, Missing); pituitary gland: 91.0714% (minimum 99%, Missing); rectum: 95.3271% (minimum 97%, Missing); retina: 92.7273% (minimum 99%, Missing); salivary gland: 83.6066% (minimum 97%, Missing); skeletal muscle: 91.8919% (minimum 99%, Missing); skin: 94.4444% (minimum 95%, Missing); small intestine: 93.5780% (minimum 99%, Missing); smooth muscle: 93.5780% (minimum 99%, Missing); spinal cord: 39.8437% (minimum 99%, Missing); stomach: 94.4444% (minimum 97%, Missing); tongue: 90.2655% (minimum 97%, Missing); urinary bladder: 96.2264% (minimum 97%, Missing)",0,80,unavailable,15.4,2.7,0.6,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185634,SHC4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.00555556,-0.179302,-0.591562
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,52.8,23.1,19.1,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 2); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 2); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); thymus: 14.5 nTPM (manageable, limit 5); skin: 14.2 nTPM (manageable, limit 5); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (manageable, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 2); colon: 12.1 nTPM (protected, limit 2); urinary bladder: 12 nTPM (protected, limit 2); rectum: 11.9 nTPM (protected, limit 2); stomach: 11.8 nTPM (protected, limit 2); esophagus: 11.6 nTPM (protected, limit 2); salivary gland: 11.3 nTPM (protected, limit 2); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185658,BRWD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.7841% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.7030% (minimum 99%, Baseline (adaptation disabled)); amygdala: 35.4167% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 33.6890% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 54.5679% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.1667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 29.5060% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.4294% (minimum 99%, Baseline (adaptation disabled)); colon: 64.6199% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.9367% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.5786% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.5687% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 38.5017% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 35.4735% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.2493% (minimum 99%, Baseline (adaptation disabled)); liver: 46.9214% (minimum 99%, Baseline (adaptation disabled)); lung: 63.3238% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.9333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 42.5819% (minimum 99%, Baseline (adaptation disabled)); pancreas: 53.3816% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.6888% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.1429% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 37.1429% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.1677% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 51.1574% (minimum 99%, Baseline (adaptation disabled)); skin: 60.8815% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.7674% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.3780% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 51.0393% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.3780% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.1917% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.3825% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.6408% (minimum 95%, Baseline (adaptation disabled)); tongue: 48.8938% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.8094% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,52.8,23.1,19.1,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 2); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 2); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); thymus: 14.5 nTPM (manageable, limit 5); skin: 14.2 nTPM (manageable, limit 5); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (manageable, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 2); colon: 12.1 nTPM (protected, limit 2); urinary bladder: 12 nTPM (protected, limit 2); rectum: 11.9 nTPM (protected, limit 2); stomach: 11.8 nTPM (protected, limit 2); esophagus: 11.6 nTPM (protected, limit 2); salivary gland: 11.3 nTPM (protected, limit 2); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185658,BRWD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.413592,-0.481062,-0.69494
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.7841% (minimum 95%, Missing); adrenal gland: 54.7030% (minimum 99%, Missing); amygdala: 35.4167% (minimum 99%, Missing); basal ganglia: 33.6890% (minimum 99%, Missing); bone marrow: 54.5679% (minimum 99%, Missing); cerebellum: 54.1667% (minimum 99%, Missing); cerebral cortex: 29.5060% (minimum 99%, Missing); choroid plexus: 62.4294% (minimum 99%, Missing); colon: 64.6199% (minimum 97%, Missing); duodenum: 69.9367% (minimum 99%, Missing); esophagus: 65.5786% (minimum 97%, Missing); heart muscle: 59.5687% (minimum 99%, Missing); hippocampal formation: 38.5017% (minimum 99%, Missing); hypothalamus: 35.4735% (minimum 99%, Missing); kidney: 59.2493% (minimum 99%, Missing); liver: 46.9214% (minimum 99%, Missing); lung: 63.3238% (minimum 99%, Missing); lymph node: 58.9333% (minimum 97%, Missing); midbrain: 42.5819% (minimum 99%, Missing); pancreas: 53.3816% (minimum 99%, Missing); parathyroid gland: 63.6888% (minimum 97%, Missing); pituitary gland: 63.1429% (minimum 99%, Missing); rectum: 65.0000% (minimum 97%, Missing); retina: 37.1429% (minimum 99%, Missing); salivary gland: 66.1677% (minimum 97%, Missing); skeletal muscle: 51.1574% (minimum 99%, Missing); skin: 60.8815% (minimum 95%, Missing); small intestine: 66.7674% (minimum 99%, Missing); smooth muscle: 67.3780% (minimum 99%, Missing); spinal cord: 51.0393% (minimum 99%, Missing); spleen: 67.3780% (minimum 95%, Missing); stomach: 65.1917% (minimum 97%, Missing); thymus: 60.3825% (minimum 95%, Missing); thyroid gland: 53.6408% (minimum 95%, Missing); tongue: 48.8938% (minimum 97%, Missing); urinary bladder: 64.8094% (minimum 97%, Missing)",0,1,partial,52.8,23.1,19.1,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 2); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 2); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); thymus: 14.5 nTPM (manageable, limit 5); skin: 14.2 nTPM (manageable, limit 5); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (manageable, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 2); colon: 12.1 nTPM (protected, limit 2); urinary bladder: 12 nTPM (protected, limit 2); rectum: 11.9 nTPM (protected, limit 2); stomach: 11.8 nTPM (protected, limit 2); esophagus: 11.6 nTPM (protected, limit 2); salivary gland: 11.3 nTPM (protected, limit 2); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185658,BRWD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.413592,-0.481062,-0.69494
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000185662,SMIM23,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000185662,SMIM23,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0459016,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000185662,SMIM23,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0459016,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,5.1,1.3,1.3,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185666,SYN3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 86.0465% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.2222% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.9123% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 63.7931% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 62.7119% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 42.0455% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.0952% (minimum 99%, Baseline (adaptation disabled)); colon: 88.0952% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.0465% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.0952% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.2727% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.0714% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.0909% (minimum 99%, Baseline (adaptation disabled)); liver: 90.2439% (minimum 99%, Baseline (adaptation disabled)); lung: 84.0909% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.7234% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.5102% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.0909% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.5000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.8113% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.2439% (minimum 97%, Baseline (adaptation disabled)); retina: 51.3889% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.0952% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.0952% (minimum 99%, Baseline (adaptation disabled)); skin: 77.0833% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.4348% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.0952% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.5490% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.0909% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.2439% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.0465% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.2439% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.8718% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,5.1,1.3,1.3,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185666,SYN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.21,-0.23,-0.569545
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 86.0465% (minimum 95%, Uncertain); adrenal gland: 82.2222% (minimum 99%, Uncertain); amygdala: 64.9123% (minimum 99%, Missing); basal ganglia: 63.7931% (minimum 99%, Missing); bone marrow: 62.7119% (minimum 99%, Uncertain); cerebellum: 74.0000% (minimum 99%, Missing); cerebral cortex: 42.0455% (minimum 99%, Missing); choroid plexus: 88.0952% (minimum 99%, Missing); colon: 88.0952% (minimum 97%, Uncertain); duodenum: 86.0465% (minimum 99%, Uncertain); esophagus: 74.0000% (minimum 97%, Uncertain); heart muscle: 88.0952% (minimum 99%, Uncertain); hippocampal formation: 67.2727% (minimum 99%, Missing); hypothalamus: 66.0714% (minimum 99%, Missing); kidney: 84.0909% (minimum 99%, Uncertain); liver: 90.2439% (minimum 99%, Uncertain); lung: 84.0909% (minimum 99%, Uncertain); lymph node: 78.7234% (minimum 97%, Uncertain); midbrain: 75.5102% (minimum 99%, Missing); pancreas: 84.0909% (minimum 99%, Uncertain); parathyroid gland: 92.5000% (minimum 97%, Uncertain); pituitary gland: 69.8113% (minimum 99%, Missing); rectum: 90.2439% (minimum 97%, Uncertain); retina: 51.3889% (minimum 99%, Missing); salivary gland: 88.0952% (minimum 97%, Uncertain); skeletal muscle: 88.0952% (minimum 99%, Uncertain); skin: 77.0833% (minimum 95%, Uncertain); small intestine: 80.4348% (minimum 99%, Uncertain); smooth muscle: 88.0952% (minimum 99%, Uncertain); spinal cord: 72.5490% (minimum 99%, Missing); spleen: 74.0000% (minimum 95%, Uncertain); stomach: 84.0909% (minimum 97%, Uncertain); thymus: 90.2439% (minimum 95%, Missing); thyroid gland: 86.0465% (minimum 95%, Missing); tongue: 90.2439% (minimum 97%, Missing); urinary bladder: 94.8718% (minimum 97%, Uncertain)",0,2,partial,5.1,1.3,1.3,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185666,SYN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.21,-0.23,-0.569545
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,3,4.8,5.6,"skin: 5.6 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); salivary gland: 3.3 nTPM (protected, limit 2); tongue: 3.1 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185670,ZBTB3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.3636% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.3636% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.3636% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.6842% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.6154% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.6842% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.6364% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 64.6154% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.6250% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.1549% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.2453% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.1864% (minimum 99%, Baseline (adaptation disabled)); liver: 71.1864% (minimum 99%, Baseline (adaptation disabled)); lung: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.6154% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 63.6364% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.7692% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.7419% (minimum 97%, Baseline (adaptation disabled)); retina: 58.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.8696% (minimum 99%, Baseline (adaptation disabled)); skin: 42.8571% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.6250% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.1864% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.4138% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.7419% (minimum 95%, Baseline (adaptation disabled)); stomach: 46.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.8696% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.7647% (minimum 95%, Baseline (adaptation disabled)); tongue: 57.5342% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,3,4.8,5.6,"skin: 5.6 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); salivary gland: 3.3 nTPM (protected, limit 2); tongue: 3.1 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); liver: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185670,ZBTB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.521429,-0.503333,-0.406667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 76.3636% (minimum 95%, Missing); adrenal gland: 76.3636% (minimum 99%, Missing); amygdala: 76.3636% (minimum 99%, Missing); basal ganglia: 73.6842% (minimum 99%, Missing); bone marrow: 64.6154% (minimum 99%, Missing); cerebellum: 73.6842% (minimum 99%, Missing); cerebral cortex: 63.6364% (minimum 99%, Missing); choroid plexus: 84.0000% (minimum 99%, Missing); colon: 64.6154% (minimum 97%, Missing); duodenum: 65.6250% (minimum 99%, Missing); esophagus: 70.0000% (minimum 97%, Missing); heart muscle: 59.1549% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 79.2453% (minimum 99%, Missing); kidney: 71.1864% (minimum 99%, Missing); liver: 71.1864% (minimum 98%, Approved); lung: 60.0000% (minimum 99%, Missing); lymph node: 64.6154% (minimum 97%, Missing); midbrain: 75.0000% (minimum 99%, Missing); pancreas: 63.6364% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 80.7692% (minimum 99%, Missing); rectum: 67.7419% (minimum 97%, Missing); retina: 58.3333% (minimum 99%, Missing); salivary gland: 56.0000% (minimum 97%, Missing); skeletal muscle: 60.8696% (minimum 99%, Missing); skin: 42.8571% (minimum 95%, Missing); small intestine: 65.6250% (minimum 99%, Missing); smooth muscle: 71.1864% (minimum 99%, Missing); spinal cord: 72.4138% (minimum 99%, Missing); spleen: 67.7419% (minimum 90%, Approved); stomach: 46.6667% (minimum 97%, Missing); thymus: 60.8696% (minimum 95%, Missing); thyroid gland: 61.7647% (minimum 95%, Missing); tongue: 57.5342% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,1,partial,3,4.8,5.6,"skin: 5.6 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 2); salivary gland: 3.3 nTPM (protected, limit 2); tongue: 3.1 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185670,ZBTB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.521429,-0.503333,-0.406667
True,compatible,,True,True,False,,0,3,partial,3.6,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185686,PRAME,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.5974% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2692% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,3.6,0.2,0.2,"adrenal gland: 3.6 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185686,PRAME,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0480469,0.0280469,-0.0240265
True,compatible,,True,True,True,,0,3,partial,3.6,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185686,PRAME,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0480469,0.03,0.00319728
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,5.7,19.7,7.4,"lymph node: 19.7 nTPM (protected, limit 2); spleen: 7.4 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185697,MYBL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.9355% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.2149% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.9355% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.9355% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.0144% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.0625% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.3721% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.4359% (minimum 99%, Baseline (adaptation disabled)); colon: 91.9355% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.4762% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.2149% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.5510% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.7638% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.6829% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.6102% (minimum 99%, Baseline (adaptation disabled)); liver: 85.0746% (minimum 99%, Baseline (adaptation disabled)); lung: 83.2117% (minimum 99%, Baseline (adaptation disabled)); lymph node: 36.6559% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.6923% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2759% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.6102% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.6102% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.0625% (minimum 97%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.7983% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.6829% (minimum 99%, Baseline (adaptation disabled)); skin: 90.4762% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.3636% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.8235% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.7203% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.6383% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.7638% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.6087% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.2149% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 91.2000% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,5.7,19.7,7.4,"lymph node: 19.7 nTPM (protected, limit 2); spleen: 7.4 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185697,MYBL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.343617,-0.603441,-0.323333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 91.9355% (minimum 95%, Uncertain); adrenal gland: 94.2149% (minimum 99%, Missing); amygdala: 91.9355% (minimum 99%, Missing); basal ganglia: 91.9355% (minimum 99%, Missing); bone marrow: 82.0144% (minimum 99%, Uncertain); cerebellum: 89.0625% (minimum 99%, Missing); cerebral cortex: 88.3721% (minimum 99%, Missing); choroid plexus: 97.4359% (minimum 99%, Missing); colon: 91.9355% (minimum 97%, Missing); duodenum: 90.4762% (minimum 99%, Missing); esophagus: 94.2149% (minimum 97%, Uncertain); heart muscle: 77.5510% (minimum 99%, Uncertain); hippocampal formation: 89.7638% (minimum 99%, Missing); hypothalamus: 92.6829% (minimum 99%, Missing); kidney: 96.6102% (minimum 99%, Missing); liver: 85.0746% (minimum 99%, Uncertain); lung: 83.2117% (minimum 99%, Uncertain); lymph node: 36.6559% (minimum 97%, Uncertain); midbrain: 87.6923% (minimum 99%, Missing); pancreas: 98.2759% (minimum 99%, Missing); parathyroid gland: 96.6102% (minimum 97%, Uncertain); pituitary gland: 96.6102% (minimum 99%, Missing); rectum: 89.0625% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 95.7983% (minimum 97%, Uncertain); skeletal muscle: 92.6829% (minimum 99%, Missing); skin: 90.4762% (minimum 95%, Uncertain); small intestine: 86.3636% (minimum 99%, Missing); smooth muscle: 83.8235% (minimum 99%, Uncertain); spinal cord: 79.7203% (minimum 99%, Missing); spleen: 60.6383% (minimum 95%, Uncertain); stomach: 89.7638% (minimum 97%, Missing); thymus: 82.6087% (minimum 95%, Missing); tongue: 94.2149% (minimum 97%, Missing); urinary bladder: 91.2000% (minimum 97%, Uncertain)",0,3,partial,5.7,19.7,7.4,"lymph node: 19.7 nTPM (protected, limit 2); spleen: 7.4 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185697,MYBL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.343617,-0.603441,-0.323333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.9,5.5,6.3,"skin: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); spinal cord: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); retina: 3.5 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); tongue: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185730,ZNF696,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.0864% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 51.8072% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 51.8072% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.1282% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 44.3299% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 42.5743% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.8814% (minimum 99%, Baseline (adaptation disabled)); colon: 57.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 42.1569% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.2353% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.5634% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 46.2366% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 48.8636% (minimum 99%, Baseline (adaptation disabled)); lung: 61.4286% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.7500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 53.0864% (minimum 99%, Baseline (adaptation disabled)); pancreas: 46.7391% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.5882% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.1081% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.3548% (minimum 97%, Baseline (adaptation disabled)); retina: 55.1282% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 43.8776% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 53.7500% (minimum 99%, Baseline (adaptation disabled)); skin: 40.5660% (minimum 95%, Baseline (adaptation disabled)); small intestine: 54.4304% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.1538% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 54.4304% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.4390% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.1875% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.4304% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.1515% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.4304% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.9,5.5,6.3,"skin: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); spinal cord: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); retina: 3.5 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); tongue: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185730,ZNF696,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.54434,-0.531224,-0.568431
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.0864% (minimum 95%, Missing); adrenal gland: 57.3333% (minimum 99%, Missing); amygdala: 51.8072% (minimum 99%, Missing); basal ganglia: 51.8072% (minimum 99%, Missing); bone marrow: 55.1282% (minimum 99%, Missing); cerebellum: 44.3299% (minimum 99%, Missing); cerebral cortex: 42.5743% (minimum 99%, Missing); choroid plexus: 72.8814% (minimum 99%, Missing); colon: 57.3333% (minimum 97%, Missing); duodenum: 42.1569% (minimum 99%, Missing); esophagus: 63.2353% (minimum 97%, Missing); heart muscle: 60.5634% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 46.2366% (minimum 99%, Missing); kidney: 57.3333% (minimum 99%, Missing); liver: 48.8636% (minimum 99%, Missing); lung: 61.4286% (minimum 99%, Missing); lymph node: 53.7500% (minimum 97%, Missing); midbrain: 53.0864% (minimum 99%, Missing); pancreas: 46.7391% (minimum 99%, Missing); parathyroid gland: 50.5882% (minimum 97%, Missing); pituitary gland: 58.1081% (minimum 99%, Missing); rectum: 69.3548% (minimum 97%, Missing); retina: 55.1282% (minimum 99%, Missing); salivary gland: 43.8776% (minimum 97%, Missing); skeletal muscle: 53.7500% (minimum 99%, Missing); skin: 40.5660% (minimum 95%, Missing); small intestine: 54.4304% (minimum 99%, Missing); smooth muscle: 66.1538% (minimum 99%, Missing); spinal cord: 54.4304% (minimum 99%, Missing); spleen: 52.4390% (minimum 95%, Missing); stomach: 57.3333% (minimum 97%, Missing); thymus: 67.1875% (minimum 95%, Missing); thyroid gland: 54.4304% (minimum 95%, Missing); tongue: 65.1515% (minimum 97%, Missing); urinary bladder: 54.4304% (minimum 97%, Missing)",0,80,unavailable,5.9,5.5,6.3,"skin: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 2); spinal cord: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); retina: 3.5 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); tongue: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185730,ZNF696,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.54434,-0.531224,-0.568431
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000185775,SPATA31A6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000185775,SPATA31A6,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000185775,SPATA31A6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,False,,0,2,unreliable,0.1,0,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / Langerhans; tonsil / squamous epithelial cells,ENSG00000185792,NLRP9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"bone marrow: 95.2381% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.2381% (minimum 99%, Baseline (adaptation disabled))",0,2,unreliable,0.1,0,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / Langerhans; tonsil / squamous epithelial cells,ENSG00000185792,NLRP9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,0.03,-0.037619
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"bone marrow: 95.2381% (minimum 99%, Missing); kidney: 95.2381% (minimum 99%, Missing)",0,2,unreliable,0.1,0,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / Langerhans; tonsil / squamous epithelial cells,ENSG00000185792,NLRP9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,0.03,-0.037619
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,14.5,12.1,11.8,"bone marrow: 14.5 nTPM (vital, limit 2); skeletal muscle: 12.6 nTPM (vital, limit 2); tongue: 12.1 nTPM (protected, limit 2); thymus: 11.8 nTPM (manageable, limit 5); skin: 11.6 nTPM (manageable, limit 10); choroid plexus: 11.5 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 10); lymph node: 10.3 nTPM (protected, limit 4); liver: 9.7 nTPM (vital, limit 2); parathyroid gland: 9.6 nTPM (protected, limit 2); esophagus: 8.7 nTPM (protected, limit 4); kidney: 8.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 2); colon: 7.8 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 2); adrenal gland: 7.1 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); urinary bladder: 7 nTPM (protected, limit 2); cerebellum: 7 nTPM (vital, limit 2); rectum: 6.9 nTPM (protected, limit 2); thyroid gland: 6.9 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 2); spinal cord: 6.7 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000185798,WDR53,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.5779% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.0354% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.3175% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.3815% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.2564% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.1504% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.4359% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.2440% (minimum 99%, Baseline (adaptation disabled)); colon: 90.2378% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.4954% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.2327% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.2378% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.8471% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.9643% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.3432% (minimum 99%, Baseline (adaptation disabled)); liver: 88.1418% (minimum 99%, Baseline (adaptation disabled)); lung: 91.4975% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.8471% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.6735% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.2497% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.7303% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.2658% (minimum 97%, Baseline (adaptation disabled)); retina: 89.3432% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.3815% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.1240% (minimum 99%, Baseline (adaptation disabled)); skin: 86.1410% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.3509% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.0354% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.4975% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.1826% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.1504% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.9356% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 91.2658% (minimum 95%, Baseline (adaptation disabled)); tongue: 85.6295% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 91.1504% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,14.5,12.1,11.8,"bone marrow: 14.5 nTPM (vital, limit 1); skeletal muscle: 12.6 nTPM (vital, limit 1); tongue: 12.1 nTPM (protected, limit 2); thymus: 11.8 nTPM (manageable, limit 5); skin: 11.6 nTPM (manageable, limit 5); choroid plexus: 11.5 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 2); liver: 9.7 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 2); esophagus: 8.7 nTPM (protected, limit 2); kidney: 8.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 1); colon: 7.8 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); adipose tissue: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.1 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); urinary bladder: 7 nTPM (protected, limit 2); cerebellum: 7 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 2); thyroid gland: 6.9 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000185798,WDR53,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0906436,-0.113705,-0.157436
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.0354% (minimum 99%, Missing); amygdala: 92.3175% (minimum 99%, Missing); basal ganglia: 91.3815% (minimum 99%, Missing); bone marrow: 83.2564% (minimum 98%, Approved); cerebellum: 91.1504% (minimum 98%, Approved); cerebral cortex: 92.4359% (minimum 99%, Missing); choroid plexus: 86.2440% (minimum 99%, Missing); colon: 90.2378% (minimum 97%, Missing); duodenum: 94.4954% (minimum 99%, Missing); esophagus: 89.2327% (minimum 95%, Approved); heart muscle: 90.2378% (minimum 98%, Approved); hippocampal formation: 91.8471% (minimum 99%, Missing); hypothalamus: 91.9643% (minimum 99%, Missing); kidney: 89.3432% (minimum 99%, Missing); liver: 88.1418% (minimum 98%, Approved); lung: 91.4975% (minimum 98%, Approved); lymph node: 87.5000% (minimum 95%, Approved); midbrain: 91.8471% (minimum 99%, Missing); pancreas: 92.6735% (minimum 99%, Missing); parathyroid gland: 88.2497% (minimum 97%, Missing); pituitary gland: 91.7303% (minimum 99%, Missing); rectum: 91.2658% (minimum 97%, Missing); retina: 89.3432% (minimum 99%, Missing); salivary gland: 91.3815% (minimum 97%, Missing); skeletal muscle: 85.1240% (minimum 98%, Approved); skin: 86.1410% (minimum 90%, Approved); small intestine: 90.3509% (minimum 99%, Missing); smooth muscle: 91.0354% (minimum 98%, Approved); spinal cord: 91.4975% (minimum 99%, Missing); spleen: 87.1826% (minimum 90%, Approved); stomach: 91.1504% (minimum 97%, Missing); thymus: 85.9356% (minimum 95%, Missing); thyroid gland: 91.2658% (minimum 95%, Missing); tongue: 85.6295% (minimum 97%, Missing); urinary bladder: 91.1504% (minimum 97%, Missing)",0,5,partial,14.5,12.1,11.8,"bone marrow: 14.5 nTPM (vital, limit 2); skeletal muscle: 12.6 nTPM (vital, limit 2); tongue: 12.1 nTPM (protected, limit 2); thymus: 11.8 nTPM (manageable, limit 5); skin: 11.6 nTPM (manageable, limit 10); choroid plexus: 11.5 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 10); lymph node: 10.3 nTPM (protected, limit 4); liver: 9.7 nTPM (vital, limit 2); parathyroid gland: 9.6 nTPM (protected, limit 2); esophagus: 8.7 nTPM (protected, limit 4); kidney: 8.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 2); colon: 7.8 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 2); adrenal gland: 7.1 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); urinary bladder: 7 nTPM (protected, limit 2); cerebellum: 7 nTPM (vital, limit 2); rectum: 6.9 nTPM (protected, limit 2); thyroid gland: 6.9 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 2); spinal cord: 6.7 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000185798,WDR53,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0906436,-0.113705,-0.147436
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,ENSG00000185823,NPAP1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 87.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.8485% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.5517% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.3226% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.7778% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.5517% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.5517% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.5000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 93.3333% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.5517% (minimum 99%, Baseline (adaptation disabled)); skin: 93.3333% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 93.3333% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.5517% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 84.8485% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.5517% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,ENSG00000185823,NPAP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.101515,-0.00448276,-0.212222
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 84.8485% (minimum 99%, Missing); duodenum: 96.5517% (minimum 99%, Missing); hypothalamus: 90.3226% (minimum 99%, Missing); kidney: 77.7778% (minimum 99%, Missing); lymph node: 96.5517% (minimum 97%, Missing); midbrain: 96.5517% (minimum 99%, Missing); pancreas: 87.5000% (minimum 99%, Missing); pituitary gland: 87.5000% (minimum 99%, Missing); retina: 93.3333% (minimum 99%, Missing); skeletal muscle: 96.5517% (minimum 99%, Missing); skin: 93.3333% (minimum 95%, Missing); spinal cord: 93.3333% (minimum 99%, Missing); stomach: 96.5517% (minimum 97%, Missing); thyroid gland: 84.8485% (minimum 95%, Missing); urinary bladder: 96.5517% (minimum 97%, Missing)",0,80,unavailable,0.8,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,ENSG00000185823,NPAP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.101515,-0.00448276,-0.212222
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,33.6,21.5,19.5,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 2); tongue: 19.8 nTPM (protected, limit 2); thymus: 19.5 nTPM (manageable, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 2); thyroid gland: 18 nTPM (manageable, limit 5); bone marrow: 18 nTPM (vital, limit 1); skin: 17.6 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 2); spleen: 14.4 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); salivary gland: 11 nTPM (protected, limit 2); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); stomach: 10.3 nTPM (protected, limit 2); esophagus: 9.8 nTPM (protected, limit 2); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000185829,ARL17A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.4275% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 77.2277% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.0361% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.4211% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.4463% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.4124% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.6215% (minimum 99%, Baseline (adaptation disabled)); colon: 75.7282% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.2333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.9180% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 78.7879% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.9031% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.8597% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.2896% (minimum 99%, Baseline (adaptation disabled)); liver: 73.3083% (minimum 99%, Baseline (adaptation disabled)); lung: 74.8560% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.7804% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.8383% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.9129% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.4628% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.3012% (minimum 97%, Baseline (adaptation disabled)); retina: 53.7190% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.2718% (minimum 99%, Baseline (adaptation disabled)); skin: 68.9046% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.9129% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.3575% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.9031% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.0337% (minimum 95%, Baseline (adaptation disabled)); stomach: 79.1075% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.4211% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.3265% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.9474% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,33.6,21.5,19.5,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 2); tongue: 19.8 nTPM (protected, limit 2); thymus: 19.5 nTPM (manageable, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 2); thyroid gland: 18 nTPM (manageable, limit 5); bone marrow: 18 nTPM (vital, limit 1); skin: 17.6 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 2); spleen: 14.4 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); salivary gland: 11 nTPM (protected, limit 2); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); stomach: 10.3 nTPM (protected, limit 2); esophagus: 9.8 nTPM (protected, limit 2); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000185829,ARL17A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.283333,-0.325372,-0.45281
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.4275% (minimum 95%, Uncertain); adrenal gland: 77.2277% (minimum 99%, Missing); amygdala: 88.0361% (minimum 99%, Missing); basal ganglia: 86.6667% (minimum 99%, Missing); bone marrow: 68.4211% (minimum 99%, Uncertain); cerebellum: 73.4463% (minimum 99%, Missing); cerebral cortex: 80.4124% (minimum 99%, Missing); choroid plexus: 63.6215% (minimum 99%, Missing); colon: 75.7282% (minimum 97%, Missing); duodenum: 84.2333% (minimum 99%, Missing); esophagus: 79.9180% (minimum 97%, Missing); heart muscle: 78.7879% (minimum 99%, Missing); hippocampal formation: 85.9031% (minimum 99%, Missing); hypothalamus: 86.8597% (minimum 99%, Missing); kidney: 75.2896% (minimum 99%, Missing); liver: 73.3083% (minimum 99%, Missing); lung: 74.8560% (minimum 99%, Missing); lymph node: 70.7804% (minimum 97%, Missing); midbrain: 88.8383% (minimum 99%, Missing); pancreas: 80.9129% (minimum 99%, Missing); parathyroid gland: 64.4628% (minimum 97%, Missing); pituitary gland: 75.0000% (minimum 99%, Missing); rectum: 68.3012% (minimum 97%, Missing); retina: 53.7190% (minimum 99%, Missing); salivary gland: 78.0000% (minimum 97%, Uncertain); skeletal muscle: 69.2718% (minimum 99%, Uncertain); skin: 68.9046% (minimum 95%, Missing); small intestine: 80.9129% (minimum 99%, Missing); smooth muscle: 67.3575% (minimum 99%, Missing); spinal cord: 85.9031% (minimum 99%, Missing); spleen: 73.0337% (minimum 95%, Missing); stomach: 79.1075% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 68.4211% (minimum 95%, Missing); tongue: 66.3265% (minimum 97%, Missing); urinary bladder: 78.9474% (minimum 97%, Missing)",0,6,partial,33.6,21.5,19.5,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 2); tongue: 19.8 nTPM (protected, limit 2); thymus: 19.5 nTPM (manageable, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 2); thyroid gland: 18 nTPM (manageable, limit 5); bone marrow: 18 nTPM (vital, limit 1); skin: 17.6 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 2); spleen: 14.4 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 2); adrenal gland: 11.5 nTPM (vital, limit 1); salivary gland: 11 nTPM (protected, limit 2); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); stomach: 10.3 nTPM (protected, limit 2); esophagus: 9.8 nTPM (protected, limit 2); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000185829,ARL17A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.283333,-0.325372,-0.45281
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,6.4,2.5,4.2,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185842,DNAH14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.3984% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.0736% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.1327% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.2747% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6239% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.0736% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.9582% (minimum 99%, Baseline (adaptation disabled)); colon: 92.2747% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.5556% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.1327% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.2982% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.0736% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.3137% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.2239% (minimum 99%, Baseline (adaptation disabled)); liver: 79.6296% (minimum 99%, Baseline (adaptation disabled)); lung: 90.7173% (minimum 99%, Baseline (adaptation disabled)); midbrain: 92.2747% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.6296% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.8803% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.0609% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.7173% (minimum 97%, Baseline (adaptation disabled)); retina: 89.2116% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.8865% (minimum 97%, Baseline (adaptation disabled)); small intestine: 97.2851% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.5556% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.3984% (minimum 99%, Baseline (adaptation disabled)); stomach: 89.5833% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.2982% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 83.6576% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.2747% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,6.4,2.5,4.2,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185842,DNAH14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.113424,-0.0741667,-0.219391
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.3984% (minimum 99%, Missing); amygdala: 93.0736% (minimum 99%, Missing); basal ganglia: 95.1327% (minimum 99%, Missing); bone marrow: 92.2747% (minimum 99%, Uncertain); cerebellum: 98.6239% (minimum 99%, Uncertain); cerebral cortex: 93.0736% (minimum 99%, Uncertain); choroid plexus: 89.9582% (minimum 99%, Missing); colon: 92.2747% (minimum 97%, Missing); duodenum: 95.5556% (minimum 99%, Uncertain); esophagus: 95.1327% (minimum 97%, Uncertain); heart muscle: 94.2982% (minimum 99%, Uncertain); hippocampal formation: 93.0736% (minimum 99%, Missing); hypothalamus: 84.3137% (minimum 99%, Missing); kidney: 80.2239% (minimum 99%, Missing); liver: 79.6296% (minimum 99%, Uncertain); lung: 90.7173% (minimum 99%, Uncertain); midbrain: 92.2747% (minimum 99%, Missing); pancreas: 79.6296% (minimum 99%, Uncertain); parathyroid gland: 91.8803% (minimum 97%, Uncertain); pituitary gland: 77.0609% (minimum 99%, Missing); rectum: 90.7173% (minimum 97%, Uncertain); retina: 89.2116% (minimum 99%, Missing); salivary gland: 93.8865% (minimum 97%, Uncertain); small intestine: 97.2851% (minimum 99%, Uncertain); smooth muscle: 95.5556% (minimum 99%, Uncertain); spinal cord: 87.3984% (minimum 99%, Missing); stomach: 89.5833% (minimum 97%, Uncertain); thymus: 94.2982% (minimum 95%, Missing); thyroid gland: 83.6576% (minimum 95%, Uncertain); urinary bladder: 92.2747% (minimum 97%, Uncertain)",0,3,partial,6.4,2.5,4.2,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185842,DNAH14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.113424,-0.0741667,-0.219391
True,compatible,,True,True,False,,0,1,partial,0.2,1.4,0,,,55,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000185863,TMEM210,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 98.6301% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.1392% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,0.2,1.4,0,,,55,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000185863,TMEM210,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,0.05,-0.0586076,-0.00369863
True,compatible,,True,True,True,,0,1,partial,0.2,1.4,0,,,55,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000185863,TMEM210,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,589.8,327.5,272.5,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 2); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); skin: 272.5 nTPM (manageable, limit 5); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); spleen: 216.6 nTPM (manageable, limit 5); salivary gland: 207.8 nTPM (protected, limit 2); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (manageable, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 2); colon: 167 nTPM (protected, limit 2); thyroid gland: 161.7 nTPM (manageable, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 2); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 2); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 2); lymph node: 49.6 nTPM (protected, limit 2); thymus: 43.7 nTPM (manageable, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185883,ATP6V0C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.5282% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 45.6176% (minimum 99%, Baseline (adaptation disabled)); amygdala: 35.4634% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 34.0508% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.7020% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 30.4302% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 25.4079% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 47.6857% (minimum 99%, Baseline (adaptation disabled)); colon: 54.6072% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.5432% (minimum 99%, Baseline (adaptation disabled)); esophagus: 38.0204% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 49.5193% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 34.1550% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 32.9398% (minimum 99%, Baseline (adaptation disabled)); kidney: 33.2726% (minimum 99%, Baseline (adaptation disabled)); liver: 49.8759% (minimum 99%, Baseline (adaptation disabled)); lung: 47.3374% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.1996% (minimum 97%, Baseline (adaptation disabled)); midbrain: 38.4424% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.5612% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.7220% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 38.6792% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 65.2273% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 49.1559% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 40.8915% (minimum 99%, Baseline (adaptation disabled)); skin: 42.4377% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.6973% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.4619% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 42.6720% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.1198% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.0926% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.1341% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.4054% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.5014% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.7132% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,589.8,327.5,272.5,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 2); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); skin: 272.5 nTPM (manageable, limit 5); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); spleen: 216.6 nTPM (manageable, limit 5); salivary gland: 207.8 nTPM (protected, limit 2); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (manageable, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 2); colon: 167 nTPM (protected, limit 2); thyroid gland: 161.7 nTPM (manageable, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 2); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 2); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 2); lymph node: 49.6 nTPM (protected, limit 2); thymus: 43.7 nTPM (manageable, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185883,ATP6V0C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.525623,-0.589796,-0.735921
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.5282% (minimum 95%, Missing); adrenal gland: 45.6176% (minimum 99%, Missing); amygdala: 35.4634% (minimum 99%, Missing); basal ganglia: 34.0508% (minimum 99%, Missing); bone marrow: 52.7020% (minimum 99%, Missing); cerebellum: 30.4302% (minimum 99%, Missing); cerebral cortex: 25.4079% (minimum 99%, Missing); choroid plexus: 47.6857% (minimum 99%, Missing); colon: 54.6072% (minimum 97%, Missing); duodenum: 68.5432% (minimum 99%, Missing); esophagus: 38.0204% (minimum 97%, Missing); heart muscle: 49.5193% (minimum 99%, Missing); hippocampal formation: 34.1550% (minimum 99%, Missing); hypothalamus: 32.9398% (minimum 99%, Missing); kidney: 33.2726% (minimum 99%, Missing); liver: 49.8759% (minimum 99%, Missing); lung: 47.3374% (minimum 99%, Missing); lymph node: 80.1996% (minimum 97%, Missing); midbrain: 38.4424% (minimum 99%, Missing); pancreas: 59.5612% (minimum 99%, Missing); parathyroid gland: 66.7220% (minimum 97%, Missing); pituitary gland: 38.6792% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 65.2273% (minimum 99%, Missing); salivary gland: 49.1559% (minimum 97%, Missing); skeletal muscle: 40.8915% (minimum 99%, Missing); skin: 42.4377% (minimum 95%, Missing); small intestine: 55.6973% (minimum 99%, Missing); smooth muscle: 87.4619% (minimum 99%, Missing); spinal cord: 42.6720% (minimum 99%, Missing); spleen: 48.1198% (minimum 95%, Missing); stomach: 54.0926% (minimum 97%, Missing); thymus: 82.1341% (minimum 95%, Missing); thyroid gland: 55.4054% (minimum 95%, Missing); tongue: 79.5014% (minimum 97%, Missing); urinary bladder: 60.7132% (minimum 97%, Missing)",0,80,unavailable,589.8,327.5,272.5,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 2); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); skin: 272.5 nTPM (manageable, limit 5); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); spleen: 216.6 nTPM (manageable, limit 5); salivary gland: 207.8 nTPM (protected, limit 2); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (manageable, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 2); colon: 167 nTPM (protected, limit 2); thyroid gland: 161.7 nTPM (manageable, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 2); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 2); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 2); lymph node: 49.6 nTPM (protected, limit 2); thymus: 43.7 nTPM (manageable, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185883,ATP6V0C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.525623,-0.589796,-0.735921
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000185888,PRSS38,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 97.6190% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000185888,PRSS38,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0138095
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 97.6190% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000185888,PRSS38,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0138095
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000185894,BPY2C,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 84.6154% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000185894,BPY2C,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.143846
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 84.6154% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000185894,BPY2C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.143846
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,14.4,16.2,6.4,"stomach: 16.2 nTPM (protected, limit 2); rectum: 16 nTPM (protected, limit 2); colon: 14.9 nTPM (protected, limit 2); small intestine: 14.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 2); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); adrenal gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185920,PTCH1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.4479% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.1015% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.9945% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.9459% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0663% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.7488% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 82.7506% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.9198% (minimum 99%, Baseline (adaptation disabled)); colon: 70.4365% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.2411% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.1015% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.9319% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.7961% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.7302% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.3747% (minimum 99%, Baseline (adaptation disabled)); liver: 93.4211% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.6893% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.5275% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.3666% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.4948% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.7961% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.9320% (minimum 97%, Baseline (adaptation disabled)); retina: 81.4220% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.8656% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.9319% (minimum 99%, Baseline (adaptation disabled)); skin: 91.0256% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.1423% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.6893% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0663% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.3308% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.6654% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.1759% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.7255% (minimum 95%, Baseline (adaptation disabled)); tongue: 85.1319% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.1319% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,14.4,16.2,6.4,"stomach: 16.2 nTPM (protected, limit 2); rectum: 16 nTPM (protected, limit 2); colon: 14.9 nTPM (protected, limit 2); small intestine: 14.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 2); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); adrenal gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185920,PTCH1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.102745,-0.283346,-0.278577
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 92.4479% (minimum 95%, Missing); adrenal gland: 90.1015% (minimum 99%, Missing); amygdala: 96.9945% (minimum 99%, Missing); basal ganglia: 95.9459% (minimum 99%, Missing); bone marrow: 98.0663% (minimum 99%, Missing); cerebellum: 85.7488% (minimum 99%, Missing); cerebral cortex: 82.7506% (minimum 99%, Missing); choroid plexus: 94.9198% (minimum 99%, Missing); colon: 70.4365% (minimum 97%, Missing); duodenum: 79.2411% (minimum 99%, Missing); esophagus: 90.1015% (minimum 97%, Missing); heart muscle: 92.9319% (minimum 99%, Missing); hippocampal formation: 97.7961% (minimum 99%, Missing); hypothalamus: 96.7302% (minimum 99%, Missing); kidney: 86.3747% (minimum 99%, Missing); liver: 93.4211% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 92.6893% (minimum 97%, Missing); midbrain: 97.5275% (minimum 99%, Missing); pancreas: 82.3666% (minimum 99%, Missing); parathyroid gland: 91.4948% (minimum 97%, Missing); pituitary gland: 97.7961% (minimum 99%, Missing); rectum: 68.9320% (minimum 97%, Missing); retina: 81.4220% (minimum 99%, Missing); salivary gland: 80.8656% (minimum 97%, Missing); skeletal muscle: 92.9319% (minimum 99%, Missing); skin: 91.0256% (minimum 95%, Missing); small intestine: 71.1423% (minimum 99%, Missing); smooth muscle: 92.6893% (minimum 99%, Missing); spinal cord: 98.0663% (minimum 99%, Missing); spleen: 90.3308% (minimum 95%, Missing); stomach: 68.6654% (minimum 97%, Missing); thymus: 93.1759% (minimum 95%, Missing); thyroid gland: 84.7255% (minimum 95%, Missing); tongue: 85.1319% (minimum 97%, Missing); urinary bladder: 85.1319% (minimum 97%, Missing)",0,3,partial,14.4,16.2,6.4,"stomach: 16.2 nTPM (protected, limit 2); rectum: 16 nTPM (protected, limit 2); colon: 14.9 nTPM (protected, limit 2); small intestine: 14.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 2); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 2); urinary bladder: 6.2 nTPM (protected, limit 2); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); adrenal gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 2); lymph node: 2.8 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000185920,PTCH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.102745,-0.283346,-0.278577
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,9.1,1.5,2.5,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185955,SPACDR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.1084% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.7436% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0826% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.1926% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.0070% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.2275% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2275% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.1421% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.7231% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.5185% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8113% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6505% (minimum 99%, Baseline (adaptation disabled)); midbrain: 87.9630% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.9596% (minimum 99%, Baseline (adaptation disabled)); retina: 97.3646% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8113% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.3134% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,9.1,1.5,2.5,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185955,SPACDR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0137681,0.00794118,-0.11037
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.1084% (minimum 99%, Missing); basal ganglia: 89.7436% (minimum 99%, Missing); cerebellum: 94.1926% (minimum 95%, Enhanced); cerebral cortex: 93.0070% (minimum 95%, Enhanced); choroid plexus: 98.2275% (minimum 99%, Missing); hippocampal formation: 89.1421% (minimum 99%, Missing); hypothalamus: 90.7231% (minimum 99%, Missing); midbrain: 87.9630% (minimum 99%, Missing); pituitary gland: 95.9596% (minimum 99%, Missing); retina: 97.3646% (minimum 99%, Missing); spinal cord: 88.3134% (minimum 99%, Missing)",0,2,partial,9.1,1.5,2.5,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000185955,SPACDR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0381129,0.0225373,-0.11037
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.2,0.3,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000185958,FAM186A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8723% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.1831% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.5205% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.5035% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.5205% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.1831% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.1831% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.5035% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.1831% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.8333% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8723% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.8723% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.8723% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.8776% (minimum 99%, Baseline (adaptation disabled)); retina: 95.1724% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 92.6174% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5714% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.2,0.3,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000185958,FAM186A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0287234,0.0157143,-0.0638255
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.8723% (minimum 99%, Missing); amygdala: 97.1831% (minimum 99%, Missing); basal ganglia: 94.5205% (minimum 99%, Missing); bone marrow: 96.5035% (minimum 99%, Missing); cerebellum: 94.5205% (minimum 99%, Missing); cerebral cortex: 97.1831% (minimum 99%, Missing); heart muscle: 97.1831% (minimum 99%, Missing); hippocampal formation: 96.5035% (minimum 99%, Missing); hypothalamus: 97.1831% (minimum 99%, Missing); kidney: 95.8333% (minimum 99%, Missing); liver: 97.8723% (minimum 99%, Missing); midbrain: 97.8723% (minimum 99%, Missing); pancreas: 97.8723% (minimum 99%, Missing); pituitary gland: 93.8776% (minimum 99%, Missing); retina: 95.1724% (minimum 99%, Missing); skeletal muscle: 92.6174% (minimum 99%, Missing); small intestine: 98.5714% (minimum 99%, Missing); spinal cord: 98.5714% (minimum 99%, Missing)",0,80,unavailable,1.1,0.2,0.3,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000185958,FAM186A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0287234,0.0157143,-0.0638255
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.8,0.4,0.4,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix; gallbladder,ENSG00000185972,CCIN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.2409% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.5806% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.8,0.4,0.4,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix; gallbladder,ENSG00000185972,CCIN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0445205,0.0245205,-0.0141935
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.2409% (minimum 99%, Missing); smooth muscle: 97.5806% (minimum 99%, Missing)",0,80,unavailable,1.8,0.4,0.4,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix; gallbladder,ENSG00000185972,CCIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0445205,0.0245205,-0.0141935
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000185982,DEFB128,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000185982,DEFB128,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000185982,DEFB128,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.6,1.8,0.5,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; tonsil,ENSG00000186007,LEMD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 93.7063% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.8930% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7109% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.1685% (minimum 99%, Baseline (adaptation disabled)); retina: 97.6321% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.7509% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.6,1.8,0.5,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; tonsil,ENSG00000186007,LEMD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0407579,-0.00249097,-0.0529371
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 93.7063% (minimum 99%, Missing); duodenum: 98.8930% (minimum 99%, Missing); hypothalamus: 98.7109% (minimum 99%, Missing); kidney: 98.1685% (minimum 99%, Missing); retina: 97.6321% (minimum 99%, Missing); salivary gland: 96.7509% (minimum 97%, Missing)",0,80,unavailable,3.6,1.8,0.5,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; tonsil,ENSG00000186007,LEMD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0407579,-0.00249097,-0.0529371
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.2,1.6,2.8,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186026,ZNF284,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.8462% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 46.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.6364% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 41.1765% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 56.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 53.8462% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.8462% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.8696% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.8519% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.8462% (minimum 99%, Baseline (adaptation disabled)); liver: 58.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 56.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 58.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 48.2759% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 38.8889% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.8519% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 46.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 33.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 58.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 40.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.2759% (minimum 95%, Baseline (adaptation disabled)); tongue: 73.6842% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.2,1.6,2.8,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186026,ZNF284,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.616667,-0.503333,-0.601111
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.8462% (minimum 95%, Missing); adrenal gland: 46.6667% (minimum 99%, Missing); amygdala: 63.6364% (minimum 99%, Missing); basal ganglia: 58.3333% (minimum 99%, Missing); bone marrow: 66.6667% (minimum 99%, Missing); cerebellum: 41.1765% (minimum 99%, Missing); cerebral cortex: 58.3333% (minimum 99%, Missing); choroid plexus: 56.0000% (minimum 99%, Missing); colon: 53.8462% (minimum 97%, Missing); duodenum: 53.8462% (minimum 99%, Missing); esophagus: 60.8696% (minimum 97%, Missing); heart muscle: 51.8519% (minimum 99%, Missing); hippocampal formation: 58.3333% (minimum 99%, Missing); hypothalamus: 58.3333% (minimum 99%, Missing); kidney: 53.8462% (minimum 99%, Missing); liver: 58.3333% (minimum 99%, Missing); lung: 56.0000% (minimum 99%, Missing); lymph node: 46.6667% (minimum 97%, Missing); midbrain: 58.3333% (minimum 99%, Missing); pancreas: 56.0000% (minimum 99%, Missing); parathyroid gland: 58.3333% (minimum 97%, Missing); pituitary gland: 48.2759% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 38.8889% (minimum 99%, Missing); salivary gland: 51.8519% (minimum 97%, Missing); skeletal muscle: 46.6667% (minimum 99%, Missing); skin: 33.3333% (minimum 95%, Missing); small intestine: 50.0000% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 58.3333% (minimum 99%, Missing); spleen: 40.0000% (minimum 95%, Missing); stomach: 56.0000% (minimum 97%, Missing); thymus: 46.6667% (minimum 95%, Missing); thyroid gland: 48.2759% (minimum 95%, Missing); tongue: 73.6842% (minimum 97%, Missing); urinary bladder: 56.0000% (minimum 97%, Missing)",0,80,unavailable,2.2,1.6,2.8,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186026,ZNF284,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.616667,-0.503333,-0.601111
True,compatible,,True,True,False,,0,1,partial,0.5,0.7,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186075,ZPBP2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.5,0.7,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186075,ZPBP2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0478425,0.0224893,0.00462366
True,compatible,,True,True,True,,0,1,partial,0.5,0.7,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186075,ZPBP2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0489201,0.0289201,0.00462366
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.7,0.3,0,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000186086,NBPF6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 89.6552% (minimum 99%, Baseline (adaptation disabled)); duodenum: 92.8571% (minimum 99%, Baseline (adaptation disabled)); liver: 49.0566% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 83.8710% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.6552% (minimum 97%, Baseline (adaptation disabled)); small intestine: 76.4706% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.7,0.3,0,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000186086,NBPF6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,-0.0734483,-0.499434
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 89.6552% (minimum 99%, Missing); duodenum: 92.8571% (minimum 99%, Missing); liver: 49.0566% (minimum 99%, Missing); pituitary gland: 83.8710% (minimum 99%, Missing); rectum: 89.6552% (minimum 97%, Missing); small intestine: 76.4706% (minimum 99%, Missing)",0,80,unavailable,2.7,0.3,0,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,ENSG00000186086,NBPF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,-0.0734483,-0.499434
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,1,0.4,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000186103,ARGFX,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 23.0769% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); pancreas: 50.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 37.5000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 42.8571% (minimum 99%, Baseline (adaptation disabled)); skin: 30.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 42.8571% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 60.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1,0.4,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000186103,ARGFX,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.65,-0.541429,-0.759231
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); bone marrow: 23.0769% (minimum 99%, Missing); cerebral cortex: 60.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 60.0000% (minimum 99%, Missing); esophagus: 60.0000% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); pancreas: 50.0000% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 37.5000% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing); skeletal muscle: 42.8571% (minimum 99%, Missing); skin: 30.0000% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 42.8571% (minimum 97%, Missing); thyroid gland: 60.0000% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,80,unavailable,1,0.4,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000186103,ARGFX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.65,-0.541429,-0.759231
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000186118,TEX38,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.8,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000186118,TEX38,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0492066,0.0284144,0.00788695
True,compatible,,True,True,True,,0,80,unavailable,0.8,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,ENSG00000186118,TEX38,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0492066,0.0284144,0.00788695
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186143,PRR30,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186143,PRR30,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186143,PRR30,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,3.2,0.7,0.3,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000186150,UBL4B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 96.9582% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.9331% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,3.2,0.7,0.3,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000186150,UBL4B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0470674,0.023184,-0.0204183
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 96.9582% (minimum 99%, Missing); pituitary gland: 98.9331% (minimum 99%, Missing)",0,1,partial,3.2,0.7,0.3,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,ENSG00000186150,UBL4B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.023184,-0.0204183
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.5,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000186190,BPIFB3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"choroid plexus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 44.4444% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 44.4444% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000186190,BPIFB3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.15,-0.525556,-0.545556
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"choroid plexus: 80.0000% (minimum 99%, Missing); pituitary gland: 44.4444% (minimum 99%, Missing); salivary gland: 44.4444% (minimum 97%, Missing); thymus: 80.0000% (minimum 95%, Missing)",0,80,unavailable,0.5,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,ENSG00000186190,BPIFB3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.15,-0.525556,-0.545556
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.9,1.7,2.1,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186230,ZNF749,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.1724% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.1429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 66.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.5385% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 53.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 41.0256% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.1905% (minimum 99%, Baseline (adaptation disabled)); colon: 64.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.5385% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 66.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.5385% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.5385% (minimum 99%, Baseline (adaptation disabled)); liver: 51.6129% (minimum 99%, Baseline (adaptation disabled)); lung: 61.5385% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.4848% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.5652% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.2593% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 53.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.5385% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 29.0909% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.6129% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.1724% (minimum 99%, Baseline (adaptation disabled)); skin: 43.2432% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.1429% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.2593% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.1429% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.0588% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.1429% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.9,1.7,2.1,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186230,ZNF749,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.517568,-0.485152,-0.699091
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.1724% (minimum 95%, Missing); adrenal gland: 57.1429% (minimum 99%, Missing); amygdala: 66.6667% (minimum 99%, Missing); basal ganglia: 61.5385% (minimum 99%, Missing); bone marrow: 53.3333% (minimum 99%, Missing); cerebellum: 41.0256% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); choroid plexus: 76.1905% (minimum 99%, Missing); colon: 64.0000% (minimum 97%, Missing); duodenum: 53.3333% (minimum 99%, Missing); esophagus: 53.3333% (minimum 97%, Missing); heart muscle: 61.5385% (minimum 99%, Missing); hippocampal formation: 66.6667% (minimum 99%, Missing); hypothalamus: 61.5385% (minimum 99%, Missing); kidney: 61.5385% (minimum 99%, Missing); liver: 51.6129% (minimum 99%, Missing); lung: 61.5385% (minimum 99%, Missing); lymph node: 48.4848% (minimum 97%, Missing); midbrain: 69.5652% (minimum 99%, Missing); pancreas: 59.2593% (minimum 99%, Missing); parathyroid gland: 53.3333% (minimum 97%, Missing); pituitary gland: 61.5385% (minimum 99%, Missing); rectum: 64.0000% (minimum 97%, Missing); retina: 29.0909% (minimum 99%, Missing); salivary gland: 51.6129% (minimum 97%, Missing); skeletal muscle: 55.1724% (minimum 99%, Missing); skin: 43.2432% (minimum 95%, Missing); small intestine: 57.1429% (minimum 99%, Missing); smooth muscle: 59.2593% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 57.1429% (minimum 97%, Missing); thymus: 47.0588% (minimum 95%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); tongue: 80.0000% (minimum 97%, Missing); urinary bladder: 57.1429% (minimum 97%, Missing)",0,80,unavailable,3.9,1.7,2.1,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186230,ZNF749,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.517568,-0.485152,-0.699091
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,2,0.9,0.7,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000186280,KDM4D,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.1763% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.4756% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.8788% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.2892% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.2892% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.1763% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.2892% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.4756% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.4756% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.4756% (minimum 99%, Baseline (adaptation disabled)); lung: 98.7768% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.7768% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.4756% (minimum 99%, Baseline (adaptation disabled)); retina: 94.1691% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.4756% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.4756% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.4756% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,2,0.9,0.7,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000186280,KDM4D,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0287879,0.00289157,-0.048309
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.4756% (minimum 99%, Missing); basal ganglia: 97.8788% (minimum 99%, Missing); cerebellum: 97.2892% (minimum 99%, Missing); cerebral cortex: 97.2892% (minimum 99%, Missing); choroid plexus: 98.1763% (minimum 99%, Missing); heart muscle: 97.2892% (minimum 98%, Approved); hippocampal formation: 98.4756% (minimum 99%, Missing); hypothalamus: 98.4756% (minimum 99%, Missing); kidney: 98.4756% (minimum 99%, Missing); midbrain: 98.7768% (minimum 99%, Missing); pituitary gland: 98.4756% (minimum 99%, Missing); retina: 94.1691% (minimum 99%, Missing); spinal cord: 98.4756% (minimum 99%, Missing)",0,1,partial,2,0.9,0.7,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000186280,KDM4D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0287879,0.00289157,-0.048309
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.4,4.5,3.9,"retina: 5.4 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186300,ZNF555,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 71.7949% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.6757% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.1594% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.8732% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 67.4699% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.6842% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.3529% (minimum 99%, Baseline (adaptation disabled)); colon: 70.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.6364% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.8824% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.1594% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.1594% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.8824% (minimum 99%, Baseline (adaptation disabled)); liver: 71.7949% (minimum 99%, Baseline (adaptation disabled)); lung: 72.7273% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.8861% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.2927% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.6364% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.6757% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.7123% (minimum 97%, Baseline (adaptation disabled)); retina: 50.9091% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.7949% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.2927% (minimum 99%, Baseline (adaptation disabled)); skin: 73.6842% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.7778% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.7273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.8732% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.4699% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.7273% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.9474% (minimum 95%, Baseline (adaptation disabled)); tongue: 55.4455% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.2927% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.4,4.5,3.9,"retina: 5.4 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186300,ZNF555,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.360526,-0.415545,-0.480909
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 71.7949% (minimum 95%, Missing); adrenal gland: 75.6757% (minimum 99%, Missing); amygdala: 81.1594% (minimum 99%, Missing); basal ganglia: 78.8732% (minimum 99%, Missing); bone marrow: 67.4699% (minimum 99%, Missing); cerebellum: 70.0000% (minimum 99%, Missing); cerebral cortex: 73.6842% (minimum 99%, Missing); choroid plexus: 82.3529% (minimum 99%, Missing); colon: 70.0000% (minimum 97%, Missing); duodenum: 80.0000% (minimum 99%, Missing); esophagus: 63.6364% (minimum 97%, Missing); heart muscle: 65.8824% (minimum 99%, Missing); hippocampal formation: 81.1594% (minimum 99%, Missing); hypothalamus: 81.1594% (minimum 99%, Missing); kidney: 65.8824% (minimum 99%, Missing); liver: 71.7949% (minimum 99%, Missing); lung: 72.7273% (minimum 99%, Missing); lymph node: 70.8861% (minimum 97%, Missing); midbrain: 80.0000% (minimum 99%, Missing); pancreas: 68.2927% (minimum 99%, Missing); parathyroid gland: 63.6364% (minimum 97%, Missing); pituitary gland: 75.6757% (minimum 99%, Missing); rectum: 76.7123% (minimum 97%, Missing); retina: 50.9091% (minimum 99%, Missing); salivary gland: 71.7949% (minimum 97%, Missing); skeletal muscle: 68.2927% (minimum 99%, Missing); skin: 73.6842% (minimum 95%, Missing); small intestine: 77.7778% (minimum 99%, Missing); smooth muscle: 72.7273% (minimum 99%, Missing); spinal cord: 78.8732% (minimum 99%, Missing); spleen: 67.4699% (minimum 95%, Missing); stomach: 72.7273% (minimum 97%, Missing); thymus: 70.0000% (minimum 95%, Missing); thyroid gland: 58.9474% (minimum 95%, Missing); tongue: 55.4455% (minimum 97%, Missing); urinary bladder: 68.2927% (minimum 97%, Missing)",0,80,unavailable,5.4,4.5,3.9,"retina: 5.4 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186300,ZNF555,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.360526,-0.415545,-0.480909
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000186334,SLC36A3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 97.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000186334,SLC36A3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0364865,0.03,-0.0166667
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 97.3333% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000186334,SLC36A3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0364865,0.03,-0.0166667
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,6,partial,0.9,0,5.7,"skin: 5.7 nTPM (manageable, limit 5)",,69,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000186393,KRT26,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 83.3333% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 83.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 35.7143% (minimum 99%, Baseline (adaptation disabled)); skin: 8.0645% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,0.9,0,5.7,"skin: 5.7 nTPM (manageable, limit 5)",,69,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000186393,KRT26,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.869355,0.03,-0.632857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 83.3333% (minimum 95%, Enhanced); choroid plexus: 35.7143% (minimum 99%, Missing); skin: 8.0645% (minimum 95%, Missing)",0,6,partial,0.9,0,5.7,"skin: 5.7 nTPM (manageable, limit 5)",,69,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000186393,KRT26,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.869355,0.03,-0.632857
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.9,1.8,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186446,ZNF501,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 52.6316% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.5556% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.2381% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 51.2821% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.8235% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.2381% (minimum 99%, Baseline (adaptation disabled)); colon: 52.6316% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.9655% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.1429% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.6061% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.8235% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 68.9655% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.4286% (minimum 97%, Baseline (adaptation disabled)); midbrain: 55.5556% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.8235% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 74.0741% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.0741% (minimum 97%, Baseline (adaptation disabled)); retina: 51.2821% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.5161% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 64.5161% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.9655% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.6061% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 54.0541% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.5161% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.5161% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.4286% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.6061% (minimum 95%, Baseline (adaptation disabled)); tongue: 64.5161% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.5556% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.9,1.8,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186446,ZNF501,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.394444,-0.443684,-0.477179
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 95%, Missing); adrenal gland: 80.0000% (minimum 99%, Missing); amygdala: 52.6316% (minimum 99%, Missing); basal ganglia: 55.5556% (minimum 99%, Missing); bone marrow: 95.2381% (minimum 99%, Missing); cerebellum: 51.2821% (minimum 99%, Missing); cerebral cortex: 58.8235% (minimum 99%, Missing); choroid plexus: 95.2381% (minimum 99%, Missing); colon: 52.6316% (minimum 97%, Missing); duodenum: 83.3333% (minimum 99%, Missing); esophagus: 68.9655% (minimum 97%, Missing); heart muscle: 62.5000% (minimum 99%, Missing); hippocampal formation: 57.1429% (minimum 99%, Missing); hypothalamus: 60.6061% (minimum 99%, Missing); kidney: 58.8235% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 68.9655% (minimum 99%, Missing); lymph node: 71.4286% (minimum 97%, Missing); midbrain: 55.5556% (minimum 99%, Missing); pancreas: 58.8235% (minimum 99%, Missing); parathyroid gland: 80.0000% (minimum 97%, Missing); pituitary gland: 74.0741% (minimum 99%, Missing); rectum: 74.0741% (minimum 97%, Missing); retina: 51.2821% (minimum 99%, Missing); salivary gland: 64.5161% (minimum 97%, Missing); skeletal muscle: 62.5000% (minimum 99%, Missing); skin: 64.5161% (minimum 95%, Missing); small intestine: 68.9655% (minimum 99%, Missing); smooth muscle: 60.6061% (minimum 99%, Missing); spinal cord: 54.0541% (minimum 99%, Missing); spleen: 64.5161% (minimum 95%, Missing); stomach: 64.5161% (minimum 97%, Missing); thymus: 71.4286% (minimum 95%, Missing); thyroid gland: 60.6061% (minimum 95%, Missing); tongue: 64.5161% (minimum 97%, Missing); urinary bladder: 55.5556% (minimum 97%, Missing)",0,80,unavailable,1.9,1.8,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186446,ZNF501,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.394444,-0.443684,-0.477179
True,compatible,,True,True,False,,0,3,partial,0.3,0.3,0,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,ENSG00000186451,SPATA12,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.5149% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5149% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.3,0.3,0,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,ENSG00000186451,SPATA12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.0151485,-0.00485149
True,compatible,,True,True,True,,0,3,partial,0.3,0.3,0,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,ENSG00000186451,SPATA12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000186452,TMPRSS12,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000186452,TMPRSS12,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0452607,0.03,0.000566038
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000186452,TMPRSS12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0452607,0.03,0.000566038
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,0.9,1.9,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186453,FAM228A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7222% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.7077% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7865% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.6006% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.7077% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.2514% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.5182% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.6006% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.0563% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.9885% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7077% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.6006% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.8406% (minimum 99%, Baseline (adaptation disabled)); retina: 97.9885% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.5549% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8406% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.8406% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1510% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.7,0.9,1.9,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186453,FAM228A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00277778,0.00428571,-0.037486
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.7222% (minimum 95%, Missing); adrenal gland: 97.7077% (minimum 99%, Missing); amygdala: 95.7865% (minimum 99%, Missing); basal ganglia: 96.6006% (minimum 99%, Missing); cerebellum: 97.7077% (minimum 99%, Missing); cerebral cortex: 95.2514% (minimum 99%, Missing); heart muscle: 95.5182% (minimum 99%, Missing); hippocampal formation: 96.6006% (minimum 99%, Missing); hypothalamus: 96.0563% (minimum 99%, Missing); kidney: 97.9885% (minimum 99%, Missing); lung: 97.7077% (minimum 99%, Missing); midbrain: 96.6006% (minimum 99%, Missing); pituitary gland: 98.8406% (minimum 99%, Missing); retina: 97.9885% (minimum 99%, Missing); skeletal muscle: 98.5549% (minimum 99%, Missing); small intestine: 98.8406% (minimum 99%, Missing); smooth muscle: 98.8406% (minimum 99%, Missing); spinal cord: 97.1510% (minimum 99%, Missing)",0,80,unavailable,1.7,0.9,1.9,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186453,FAM228A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00277778,0.00428571,-0.037486
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,83.4,40.3,57.2,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); thymus: 57.2 nTPM (manageable, limit 5); bone marrow: 57.1 nTPM (vital, limit 1); spleen: 52.3 nTPM (manageable, limit 5); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (manageable, limit 5); lymph node: 40.3 nTPM (protected, limit 2); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 2); urinary bladder: 19.9 nTPM (protected, limit 2); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 2); pituitary gland: 14.5 nTPM (vital, limit 1); stomach: 13.8 nTPM (protected, limit 2); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 2); esophagus: 11.9 nTPM (protected, limit 2); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); skin: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 2); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,ENSG00000186469,GNG2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4841% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.1737% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.7185% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.4566% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.8901% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.0043% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.9437% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.1599% (minimum 99%, Baseline (adaptation disabled)); colon: 82.5599% (minimum 97%, Baseline (adaptation disabled)); duodenum: 89.6748% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.2619% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.7819% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.4378% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.4053% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.5159% (minimum 99%, Baseline (adaptation disabled)); liver: 91.0818% (minimum 99%, Baseline (adaptation disabled)); lung: 86.8504% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.2404% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.8799% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.4349% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 88.3814% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.1937% (minimum 97%, Baseline (adaptation disabled)); retina: 89.2395% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.2735% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.7465% (minimum 99%, Baseline (adaptation disabled)); skin: 94.1126% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.9704% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.9874% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.3358% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.8352% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.8799% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.8507% (minimum 95%, Baseline (adaptation disabled)); tongue: 89.8208% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.7158% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,83.4,40.3,57.2,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); thymus: 57.2 nTPM (manageable, limit 5); bone marrow: 57.1 nTPM (vital, limit 1); spleen: 52.3 nTPM (manageable, limit 5); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (manageable, limit 5); lymph node: 40.3 nTPM (protected, limit 2); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 2); urinary bladder: 19.9 nTPM (protected, limit 2); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 2); pituitary gland: 14.5 nTPM (vital, limit 1); stomach: 13.8 nTPM (protected, limit 2); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 2); esophagus: 11.9 nTPM (protected, limit 2); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); skin: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 2); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,ENSG00000186469,GNG2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.291493,-0.237596,-0.420563
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.4841% (minimum 95%, Missing); adrenal gland: 85.1737% (minimum 99%, Uncertain); amygdala: 59.7185% (minimum 99%, Missing); basal ganglia: 89.4566% (minimum 99%, Missing); bone marrow: 65.8901% (minimum 99%, Uncertain); cerebellum: 95.0043% (minimum 99%, Missing); cerebral cortex: 56.9437% (minimum 99%, Missing); choroid plexus: 80.1599% (minimum 99%, Missing); colon: 82.5599% (minimum 97%, Missing); duodenum: 89.6748% (minimum 99%, Uncertain); esophagus: 90.2619% (minimum 97%, Missing); heart muscle: 90.7819% (minimum 99%, Uncertain); hippocampal formation: 71.4378% (minimum 99%, Missing); hypothalamus: 60.4053% (minimum 99%, Missing); kidney: 94.5159% (minimum 99%, Missing); liver: 91.0818% (minimum 99%, Uncertain); lung: 86.8504% (minimum 99%, Uncertain); lymph node: 73.2404% (minimum 97%, Missing); midbrain: 88.8799% (minimum 99%, Missing); pancreas: 94.4349% (minimum 99%, Missing); pituitary gland: 88.3814% (minimum 99%, Missing); rectum: 87.1937% (minimum 97%, Uncertain); retina: 89.2395% (minimum 99%, Missing); salivary gland: 94.2735% (minimum 97%, Missing); skeletal muscle: 95.7465% (minimum 99%, Uncertain); skin: 94.1126% (minimum 95%, Missing); small intestine: 85.9704% (minimum 99%, Uncertain); smooth muscle: 86.9874% (minimum 99%, Missing); spinal cord: 90.3358% (minimum 99%, Missing); spleen: 67.8352% (minimum 95%, Missing); stomach: 88.8799% (minimum 97%, Missing); thymus: 65.8507% (minimum 95%, Missing); tongue: 89.8208% (minimum 97%, Missing); urinary bladder: 84.7158% (minimum 97%, Uncertain)",0,4,partial,83.4,40.3,57.2,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); thymus: 57.2 nTPM (manageable, limit 5); bone marrow: 57.1 nTPM (vital, limit 1); spleen: 52.3 nTPM (manageable, limit 5); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (manageable, limit 5); lymph node: 40.3 nTPM (protected, limit 2); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 2); urinary bladder: 19.9 nTPM (protected, limit 2); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 2); pituitary gland: 14.5 nTPM (vital, limit 1); stomach: 13.8 nTPM (protected, limit 2); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 2); esophagus: 11.9 nTPM (protected, limit 2); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); skin: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 2); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); parathyroid gland: 2.9 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,ENSG00000186469,GNG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.291493,-0.237596,-0.420563
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,75.1,0.1,0,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),66,not_established,not_triggered,,,ENSG00000186471,AKAP14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.0992% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0746% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7879% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 52.0434% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.2554% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.5476% (minimum 99%, Baseline (adaptation disabled)); lung: 96.3357% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.5490% (minimum 99%, Baseline (adaptation disabled)); retina: 98.6683% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,75.1,0.1,0,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),66,not_established,not_triggered,,,ENSG00000186471,AKAP14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.05,0.0287745,-0.469566
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.0992% (minimum 99%, Missing); basal ganglia: 98.0746% (minimum 99%, Missing); choroid plexus: 52.0434% (minimum 99%, Missing); hippocampal formation: 97.2554% (minimum 99%, Missing); hypothalamus: 94.5476% (minimum 99%, Missing); lung: 96.3357% (minimum 99%, Missing); midbrain: 98.5490% (minimum 99%, Missing); retina: 98.6683% (minimum 99%, Missing)",0,5,partial,75.1,0.1,0,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),66,not_established,not_triggered,,,ENSG00000186471,AKAP14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,0.05,0.03,-0.469566
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,39.4,0.3,0.3,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000186487,MYT1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 81.8182% (minimum 99%, Baseline (adaptation disabled)); amygdala: 23.6842% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 15.8358% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.1818% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 12.9808% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 12.0536% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.4286% (minimum 99%, Baseline (adaptation disabled)); colon: 94.7368% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.1818% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 18.7500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 22.5941% (minimum 99%, Baseline (adaptation disabled)); liver: 96.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1818% (minimum 99%, Baseline (adaptation disabled)); midbrain: 42.5197% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.5254% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 27.2727% (minimum 99%, Baseline (adaptation disabled)); retina: 54.0000% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.1818% (minimum 99%, Baseline (adaptation disabled)); skin: 94.7368% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.4286% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.2857% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.7368% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,39.4,0.3,0.3,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000186487,MYT1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.00263158,-0.0226316,-0.869464
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 81.8182% (minimum 99%, Missing); amygdala: 23.6842% (minimum 99%, Missing); basal ganglia: 15.8358% (minimum 99%, Missing); bone marrow: 98.1818% (minimum 99%, Missing); cerebellum: 12.9808% (minimum 99%, Missing); cerebral cortex: 12.0536% (minimum 99%, Missing); choroid plexus: 96.4286% (minimum 99%, Missing); colon: 94.7368% (minimum 97%, Missing); duodenum: 98.1818% (minimum 99%, Missing); hippocampal formation: 18.7500% (minimum 99%, Missing); hypothalamus: 22.5941% (minimum 99%, Missing); liver: 96.4286% (minimum 99%, Missing); lung: 98.1818% (minimum 99%, Missing); midbrain: 42.5197% (minimum 99%, Missing); pancreas: 91.5254% (minimum 99%, Missing); pituitary gland: 27.2727% (minimum 99%, Missing); retina: 54.0000% (minimum 99%, Missing); skeletal muscle: 98.1818% (minimum 99%, Missing); skin: 94.7368% (minimum 95%, Missing); small intestine: 96.4286% (minimum 99%, Missing); spinal cord: 64.2857% (minimum 99%, Missing); stomach: 94.7368% (minimum 97%, Missing)",0,80,unavailable,39.4,0.3,0.3,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000186487,MYT1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.00263158,-0.0226316,-0.869464
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186513,OR9Q2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186513,OR9Q2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186513,OR9Q2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.6,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000186562,DEFB105A,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.6,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000186562,DEFB105A,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0496683,0.0297512,0.00950257
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.6,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000186562,DEFB105A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0496683,0.0297512,0.00950257
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000186572,DEFB107A,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000186572,DEFB107A,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000186572,DEFB107A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,0,routine_complete,0,0.1,0,,,55,not_established,not_triggered,,,ENSG00000186579,DEFB106A,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,0,routine_complete,0,0.1,0,,,55,not_established,not_triggered,,,ENSG00000186579,DEFB106A,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.0299663,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,0,routine_complete,0,0.1,0,,,55,not_established,not_triggered,,,ENSG00000186579,DEFB106A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.4,0.6,2,"bone marrow: 8.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000186583,SPATC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 81.2918% (minimum 99%, Baseline (adaptation disabled)); lung: 97.8552% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.1183% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.8052% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,8.4,0.6,2,"bone marrow: 8.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000186583,SPATC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,-0.00194805,0.0138275,-0.177082
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 81.2918% (minimum 99%, Missing); lung: 97.8552% (minimum 99%, Missing); small intestine: 98.1183% (minimum 99%, Missing); spleen: 94.8052% (minimum 95%, Missing)",0,80,unavailable,8.4,0.6,2,"bone marrow: 8.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000186583,SPATC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Gong 2021;Loriot 2025,-0.00194805,0.0138275,-0.177082
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186599,DEFB105B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186599,DEFB105B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186599,DEFB105B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.5,1.5,4.2,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186638,KIF24,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.7826% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.7826% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.0826% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.8462% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.3214% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.1624% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.6944% (minimum 99%, Baseline (adaptation disabled)); colon: 91.5966% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.6140% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.1624% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.6140% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.9655% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.9655% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.3729% (minimum 99%, Baseline (adaptation disabled)); liver: 97.3214% (minimum 99%, Baseline (adaptation disabled)); lung: 94.7826% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.6179% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.4602% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.6140% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.9032% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.5966% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.5966% (minimum 97%, Baseline (adaptation disabled)); retina: 96.4602% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 93.9655% (minimum 99%, Baseline (adaptation disabled)); skin: 92.3729% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.6140% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.9655% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.3214% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.7826% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.1854% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 90.8333% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.7826% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.5,1.5,4.2,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186638,KIF24,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.228146,-0.0909677,-0.233056
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.7826% (minimum 99%, Missing); amygdala: 94.7826% (minimum 99%, Missing); basal ganglia: 90.0826% (minimum 99%, Missing); bone marrow: 83.8462% (minimum 99%, Missing); cerebellum: 97.3214% (minimum 99%, Missing); cerebral cortex: 93.1624% (minimum 99%, Missing); choroid plexus: 75.6944% (minimum 99%, Missing); colon: 91.5966% (minimum 97%, Missing); duodenum: 95.6140% (minimum 99%, Missing); esophagus: 93.1624% (minimum 97%, Missing); heart muscle: 95.6140% (minimum 99%, Missing); hippocampal formation: 93.9655% (minimum 99%, Missing); hypothalamus: 93.9655% (minimum 99%, Missing); kidney: 92.3729% (minimum 99%, Missing); liver: 97.3214% (minimum 99%, Missing); lung: 94.7826% (minimum 99%, Missing); lymph node: 88.6179% (minimum 97%, Missing); midbrain: 96.4602% (minimum 99%, Missing); pancreas: 95.6140% (minimum 99%, Missing); parathyroid gland: 87.9032% (minimum 97%, Missing); pituitary gland: 91.5966% (minimum 99%, Missing); rectum: 91.5966% (minimum 97%, Missing); retina: 96.4602% (minimum 99%, Missing); skeletal muscle: 93.9655% (minimum 99%, Missing); skin: 92.3729% (minimum 95%, Missing); small intestine: 95.6140% (minimum 99%, Missing); smooth muscle: 93.9655% (minimum 99%, Missing); spinal cord: 97.3214% (minimum 99%, Missing); stomach: 94.7826% (minimum 97%, Missing); thymus: 72.1854% (minimum 95%, Missing); thyroid gland: 90.8333% (minimum 95%, Missing); tongue: 94.7826% (minimum 97%, Missing)",0,80,unavailable,3.5,1.5,4.2,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186638,KIF24,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.228146,-0.0909677,-0.233056
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,False,,9,3,partial,0,0,0.5,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000186645,SPDYE17,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"skin: 50.0000% (minimum 95%, Baseline (adaptation disabled))",9,3,partial,0,0,0.5,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000186645,SPDYE17,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.45,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"skin: 50.0000% (minimum 80%, Supported)",9,3,partial,0,0,0.5,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000186645,SPDYE17,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.3,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.4,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; tonsil,ENSG00000186714,CCDC73,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.8718% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.8718% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.5000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.3684% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.3684% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.8718% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.3684% (minimum 99%, Baseline (adaptation disabled)); liver: 90.2439% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.3684% (minimum 99%, Baseline (adaptation disabled)); retina: 94.8718% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.3684% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.5000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; tonsil,ENSG00000186714,CCDC73,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.025,0.03,-0.087561
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.8718% (minimum 99%, Missing); bone marrow: 94.8718% (minimum 99%, Missing); cerebellum: 92.5000% (minimum 99%, Missing); cerebral cortex: 97.3684% (minimum 99%, Missing); choroid plexus: 97.3684% (minimum 99%, Missing); hypothalamus: 94.8718% (minimum 99%, Missing); kidney: 97.3684% (minimum 99%, Missing); liver: 90.2439% (minimum 99%, Missing); midbrain: 97.3684% (minimum 99%, Missing); retina: 94.8718% (minimum 99%, Missing); spinal cord: 97.3684% (minimum 99%, Missing); spleen: 92.5000% (minimum 95%, Missing)",0,80,unavailable,0.4,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; tonsil,ENSG00000186714,CCDC73,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.025,0.03,-0.087561
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186788,SPATA31D3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186788,SPATA31D3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000186788,SPATA31D3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,ENSG00000186790,FOXE3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 88.8889% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 53.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 88.8889% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 88.8889% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,ENSG00000186790,FOXE3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.0811111,-0.456667
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 88.8889% (minimum 99%, Missing); basal ganglia: 53.3333% (minimum 99%, Missing); cerebellum: 66.6667% (minimum 99%, Missing); cerebral cortex: 88.8889% (minimum 99%, Missing); colon: 88.8889% (minimum 97%, Missing); hippocampal formation: 88.8889% (minimum 99%, Missing); kidney: 80.0000% (minimum 99%, Missing)",0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,ENSG00000186790,FOXE3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.0811111,-0.456667
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,24.1,15.7,15.6,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 2); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 2); rectum: 13.4 nTPM (protected, limit 2); skin: 13.2 nTPM (manageable, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); hippocampal formation: 12.9 nTPM (vital, limit 1); thymus: 12.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.4 nTPM (protected, limit 2); small intestine: 12.2 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 2); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 2); basal ganglia: 11.3 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 2); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 2); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000186812,ZNF397,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.7143% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.5455% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.3156% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 57.9926% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.0976% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 58.2090% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.8272% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.8679% (minimum 99%, Baseline (adaptation disabled)); colon: 55.7143% (minimum 97%, Baseline (adaptation disabled)); duodenum: 60.2317% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.1514% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.7004% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.7368% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.9375% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.8679% (minimum 99%, Baseline (adaptation disabled)); liver: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 60.7004% (minimum 99%, Baseline (adaptation disabled)); lymph node: 49.8403% (minimum 97%, Baseline (adaptation disabled)); midbrain: 54.3554% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.5217% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.1739% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.1429% (minimum 99%, Baseline (adaptation disabled)); rectum: 53.7931% (minimum 97%, Baseline (adaptation disabled)); retina: 39.2947% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.5217% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.2090% (minimum 99%, Baseline (adaptation disabled)); skin: 54.1667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.1151% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.6466% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.9804% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.7368% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.1237% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.4854% (minimum 95%, Baseline (adaptation disabled)); tongue: 59.5420% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.5646% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,24.1,15.7,15.6,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 2); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 2); rectum: 13.4 nTPM (protected, limit 2); skin: 13.2 nTPM (manageable, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); hippocampal formation: 12.9 nTPM (vital, limit 1); thymus: 12.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.4 nTPM (protected, limit 2); small intestine: 12.2 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 2); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 2); basal ganglia: 11.3 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 2); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 2); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000186812,ZNF397,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.45,-0.471597,-0.597053
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.7143% (minimum 95%, Missing); adrenal gland: 54.5455% (minimum 99%, Missing); amygdala: 59.3156% (minimum 99%, Missing); basal ganglia: 57.9926% (minimum 99%, Missing); bone marrow: 76.0976% (minimum 99%, Missing); cerebellum: 58.2090% (minimum 99%, Missing); cerebral cortex: 51.8272% (minimum 99%, Missing); choroid plexus: 58.8679% (minimum 99%, Missing); colon: 55.7143% (minimum 97%, Missing); duodenum: 60.2317% (minimum 99%, Missing); esophagus: 62.1514% (minimum 97%, Missing); heart muscle: 60.7004% (minimum 99%, Missing); hippocampal formation: 54.7368% (minimum 99%, Missing); hypothalamus: 60.9375% (minimum 99%, Missing); kidney: 58.8679% (minimum 99%, Missing); liver: 60.0000% (minimum 99%, Missing); lung: 60.7004% (minimum 99%, Missing); lymph node: 49.8403% (minimum 97%, Missing); midbrain: 54.3554% (minimum 99%, Missing); pancreas: 56.5217% (minimum 99%, Missing); parathyroid gland: 52.1739% (minimum 97%, Missing); pituitary gland: 57.1429% (minimum 99%, Missing); rectum: 53.7931% (minimum 97%, Missing); retina: 39.2947% (minimum 99%, Missing); salivary gland: 56.5217% (minimum 97%, Missing); skeletal muscle: 58.2090% (minimum 99%, Uncertain); skin: 54.1667% (minimum 95%, Missing); small intestine: 56.1151% (minimum 99%, Missing); smooth muscle: 58.6466% (minimum 99%, Missing); spinal cord: 50.9804% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 54.7368% (minimum 97%, Missing); thymus: 55.1237% (minimum 95%, Missing); thyroid gland: 50.4854% (minimum 95%, Missing); tongue: 59.5420% (minimum 97%, Missing); urinary bladder: 57.5646% (minimum 97%, Missing)",0,2,partial,24.1,15.7,15.6,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 2); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 2); rectum: 13.4 nTPM (protected, limit 2); skin: 13.2 nTPM (manageable, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 2); hippocampal formation: 12.9 nTPM (vital, limit 1); thymus: 12.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.4 nTPM (protected, limit 2); small intestine: 12.2 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 2); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 2); basal ganglia: 11.3 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 2); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 2); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000186812,ZNF397,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.45,-0.471597,-0.597053
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,3.2,2.3,3.5,"bone marrow: 3.2 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000186871,ERCC6L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 17.9487% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.7778% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 43.7500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 38.8889% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 87.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 87.5000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 23.3333% (minimum 97%, Baseline (adaptation disabled)); pancreas: 87.5000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); rectum: 38.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 63.6364% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 53.8462% (minimum 95%, Baseline (adaptation disabled)); small intestine: 53.8462% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 16.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.5000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 77.7778% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,3.2,2.3,3.5,"bone marrow: 3.2 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000186871,ERCC6L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.783333,-0.736667,-0.810513
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 87.5000% (minimum 95%, Missing); adrenal gland: 87.5000% (minimum 99%, Missing); bone marrow: 17.9487% (minimum 99%, Missing); cerebellum: 77.7778% (minimum 98%, Approved); cerebral cortex: 87.5000% (minimum 99%, Missing); colon: 43.7500% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 38.8889% (minimum 97%, Missing); heart muscle: 87.5000% (minimum 99%, Missing); kidney: 87.5000% (minimum 99%, Missing); liver: 87.5000% (minimum 98%, Approved); lung: 87.5000% (minimum 99%, Missing); lymph node: 23.3333% (minimum 97%, Missing); pancreas: 87.5000% (minimum 99%, Missing); pituitary gland: 87.5000% (minimum 99%, Missing); rectum: 38.8889% (minimum 97%, Missing); retina: 63.6364% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 87.5000% (minimum 99%, Missing); skin: 53.8462% (minimum 95%, Missing); small intestine: 53.8462% (minimum 99%, Missing); smooth muscle: 70.0000% (minimum 99%, Missing); spleen: 58.3333% (minimum 90%, Approved); stomach: 50.0000% (minimum 97%, Missing); thymus: 16.6667% (minimum 95%, Missing); thyroid gland: 87.5000% (minimum 95%, Missing); urinary bladder: 77.7778% (minimum 97%, Missing)",0,4,partial,3.2,2.3,3.5,"bone marrow: 3.2 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000186871,ERCC6L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.783333,-0.736667,-0.810513
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.1,0.9,"hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000186897,C1QL4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 80.3922% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.1111% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.6190% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.1111% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.6190% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.1818% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.8462% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 87.2340% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.3488% (minimum 99%, Baseline (adaptation disabled)); retina: 82.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 93.1818% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 97.6190% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 82.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.1,0.9,"hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000186897,C1QL4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.13,0.00619048,-0.201538
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 80.3922% (minimum 99%, Missing); basal ganglia: 91.1111% (minimum 99%, Missing); cerebellum: 97.6190% (minimum 99%, Missing); cerebral cortex: 91.1111% (minimum 99%, Missing); choroid plexus: 97.6190% (minimum 99%, Missing); hippocampal formation: 93.1818% (minimum 99%, Missing); hypothalamus: 78.8462% (minimum 99%, Missing); kidney: 82.0000% (minimum 99%, Missing); midbrain: 87.2340% (minimum 99%, Missing); pituitary gland: 95.3488% (minimum 99%, Missing); retina: 82.0000% (minimum 99%, Missing); skin: 93.1818% (minimum 95%, Missing); spinal cord: 97.6190% (minimum 99%, Missing); thyroid gland: 82.0000% (minimum 95%, Missing)",0,80,unavailable,1.1,0.1,0.9,"hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000186897,C1QL4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.13,0.00619048,-0.201538
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,46,46.3,41.5,"esophagus: 46.3 nTPM (protected, limit 2); pancreas: 46 nTPM (vital, limit 1); skin: 41.5 nTPM (manageable, limit 5); salivary gland: 37.7 nTPM (protected, limit 2); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (manageable, limit 5); retina: 26.3 nTPM (vital, limit 1); heart muscle: 26.3 nTPM (vital, limit 1); stomach: 25.4 nTPM (protected, limit 2); urinary bladder: 25.4 nTPM (protected, limit 2); colon: 24.8 nTPM (protected, limit 2); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); spleen: 21.3 nTPM (manageable, limit 5); lymph node: 20.8 nTPM (protected, limit 2); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thymus: 18.4 nTPM (manageable, limit 5); thyroid gland: 18 nTPM (manageable, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 2); pituitary gland: 16 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 2); tongue: 13.4 nTPM (protected, limit 2); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000186918,ZNF395,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6587% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.1329% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.6810% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.5672% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 58.3618% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.6604% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.9065% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.7011% (minimum 99%, Baseline (adaptation disabled)); colon: 67.4113% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.6480% (minimum 99%, Baseline (adaptation disabled)); esophagus: 52.5615% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.1082% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.8182% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.6535% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.3243% (minimum 99%, Baseline (adaptation disabled)); liver: 58.6957% (minimum 99%, Baseline (adaptation disabled)); lung: 72.8693% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.1512% (minimum 97%, Baseline (adaptation disabled)); midbrain: 82.0800% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.7235% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.2259% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.1667% (minimum 97%, Baseline (adaptation disabled)); retina: 66.1082% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.6404% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.5672% (minimum 99%, Baseline (adaptation disabled)); skin: 55.2802% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.1275% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.7934% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.7934% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.6612% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.8840% (minimum 97%, Baseline (adaptation disabled)); thymus: 73.6011% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 74.0260% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.2890% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.8840% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,46,46.3,41.5,"esophagus: 46.3 nTPM (protected, limit 2); pancreas: 46 nTPM (vital, limit 1); skin: 41.5 nTPM (manageable, limit 5); salivary gland: 37.7 nTPM (protected, limit 2); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (manageable, limit 5); retina: 26.3 nTPM (vital, limit 1); heart muscle: 26.3 nTPM (vital, limit 1); stomach: 25.4 nTPM (protected, limit 2); urinary bladder: 25.4 nTPM (protected, limit 2); colon: 24.8 nTPM (protected, limit 2); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); spleen: 21.3 nTPM (manageable, limit 5); lymph node: 20.8 nTPM (protected, limit 2); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thymus: 18.4 nTPM (manageable, limit 5); thyroid gland: 18 nTPM (manageable, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 2); pituitary gland: 16 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 2); tongue: 13.4 nTPM (protected, limit 2); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000186918,ZNF395,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.397198,-0.444385,-0.462765
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6587% (minimum 95%, Uncertain); adrenal gland: 74.1329% (minimum 99%, Missing); amygdala: 78.6810% (minimum 99%, Missing); basal ganglia: 76.5672% (minimum 99%, Missing); bone marrow: 58.3618% (minimum 99%, Missing); cerebellum: 80.6604% (minimum 99%, Uncertain); cerebral cortex: 79.9065% (minimum 99%, Missing); choroid plexus: 69.7011% (minimum 99%, Missing); colon: 67.4113% (minimum 97%, Missing); duodenum: 71.6480% (minimum 99%, Missing); esophagus: 52.5615% (minimum 97%, Missing); heart muscle: 66.1082% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 84.6535% (minimum 99%, Missing); kidney: 69.3243% (minimum 99%, Missing); liver: 58.6957% (minimum 99%, Missing); lung: 72.8693% (minimum 99%, Missing); lymph node: 71.1512% (minimum 97%, Missing); midbrain: 82.0800% (minimum 99%, Missing); pancreas: 52.7235% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); pituitary gland: 76.2259% (minimum 99%, Missing); rectum: 79.1667% (minimum 97%, Missing); retina: 66.1082% (minimum 99%, Missing); salivary gland: 57.6404% (minimum 97%, Missing); skeletal muscle: 76.5672% (minimum 99%, Uncertain); skin: 55.2802% (minimum 95%, Missing); small intestine: 68.1275% (minimum 99%, Missing); smooth muscle: 84.7934% (minimum 99%, Uncertain); spinal cord: 84.7934% (minimum 99%, Missing); spleen: 70.6612% (minimum 95%, Uncertain); stomach: 66.8840% (minimum 97%, Missing); thymus: 73.6011% (minimum 95%, Missing); thyroid gland: 74.0260% (minimum 95%, Missing); tongue: 79.2890% (minimum 97%, Missing); urinary bladder: 66.8840% (minimum 97%, Missing)",0,3,partial,46,46.3,41.5,"esophagus: 46.3 nTPM (protected, limit 2); pancreas: 46 nTPM (vital, limit 1); skin: 41.5 nTPM (manageable, limit 5); salivary gland: 37.7 nTPM (protected, limit 2); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (manageable, limit 5); retina: 26.3 nTPM (vital, limit 1); heart muscle: 26.3 nTPM (vital, limit 1); stomach: 25.4 nTPM (protected, limit 2); urinary bladder: 25.4 nTPM (protected, limit 2); colon: 24.8 nTPM (protected, limit 2); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); spleen: 21.3 nTPM (manageable, limit 5); lymph node: 20.8 nTPM (protected, limit 2); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thymus: 18.4 nTPM (manageable, limit 5); thyroid gland: 18 nTPM (manageable, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 2); pituitary gland: 16 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 2); tongue: 13.4 nTPM (protected, limit 2); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000186918,ZNF395,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.397198,-0.444385,-0.462765
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.5,2,3.6,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186952,TMEM232,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.1818% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.6201% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2036% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.6077% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.2487% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.0414% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.9064% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6201% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.6077% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.4121% (minimum 99%, Baseline (adaptation disabled)); liver: 95.9064% (minimum 99%, Baseline (adaptation disabled)); lung: 91.1111% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.2529% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.6190% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.1304% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.1818% (minimum 99%, Baseline (adaptation disabled)); retina: 82.4121% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.4706% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.2036% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.6190% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.2529% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.7977% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 82.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.5,2,3.6,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186952,TMEM232,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.13,-0.0786957,-0.165879
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 93.1818% (minimum 99%, Missing); amygdala: 93.7143% (minimum 99%, Missing); basal ganglia: 91.6201% (minimum 99%, Missing); cerebellum: 98.2036% (minimum 99%, Missing); cerebral cortex: 90.6077% (minimum 99%, Missing); choroid plexus: 83.2487% (minimum 99%, Missing); duodenum: 97.0414% (minimum 99%, Missing); heart muscle: 95.9064% (minimum 99%, Missing); hippocampal formation: 91.6201% (minimum 99%, Missing); hypothalamus: 90.6077% (minimum 99%, Missing); kidney: 82.4121% (minimum 99%, Missing); liver: 95.9064% (minimum 99%, Missing); lung: 91.1111% (minimum 99%, Missing); midbrain: 94.2529% (minimum 99%, Missing); pancreas: 97.6190% (minimum 99%, Missing); parathyroid gland: 89.1304% (minimum 97%, Missing); pituitary gland: 93.1818% (minimum 99%, Missing); retina: 82.4121% (minimum 99%, Missing); salivary gland: 96.4706% (minimum 97%, Missing); small intestine: 98.2036% (minimum 99%, Missing); smooth muscle: 97.6190% (minimum 99%, Missing); spinal cord: 94.2529% (minimum 99%, Missing); stomach: 94.7977% (minimum 97%, Missing); thyroid gland: 82.0000% (minimum 95%, Missing)",0,80,unavailable,3.5,2,3.6,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186952,TMEM232,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.13,-0.0786957,-0.165879
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.1,2.3,3,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186976,EFCAB6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.7213% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.1193% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.9350% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7448% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.7213% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.3895% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.7448% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.7213% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.9350% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.7791% (minimum 99%, Baseline (adaptation disabled)); liver: 98.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 95.5466% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.1613% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.1197% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.5490% (minimum 99%, Baseline (adaptation disabled)); retina: 88.7218% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7448% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.7213% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 88.7218% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.1,2.3,3,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186976,EFCAB6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.062782,-0.0588031,-0.106105
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.7213% (minimum 99%, Missing); amygdala: 97.1193% (minimum 99%, Missing); basal ganglia: 95.9350% (minimum 99%, Missing); cerebellum: 98.7448% (minimum 99%, Missing); cerebral cortex: 96.7213% (minimum 99%, Missing); choroid plexus: 88.3895% (minimum 99%, Missing); duodenum: 98.7448% (minimum 99%, Missing); heart muscle: 98.3333% (minimum 99%, Missing); hippocampal formation: 96.7213% (minimum 99%, Missing); hypothalamus: 95.9350% (minimum 99%, Missing); kidney: 94.7791% (minimum 99%, Missing); liver: 98.3333% (minimum 99%, Missing); lung: 95.5466% (minimum 99%, Missing); midbrain: 98.3333% (minimum 99%, Missing); pancreas: 95.1613% (minimum 99%, Missing); parathyroid gland: 91.1197% (minimum 97%, Missing); pituitary gland: 92.5490% (minimum 99%, Missing); retina: 88.7218% (minimum 99%, Missing); smooth muscle: 98.3333% (minimum 99%, Missing); spinal cord: 98.7448% (minimum 99%, Missing); stomach: 96.7213% (minimum 97%, Missing); thyroid gland: 88.7218% (minimum 95%, Missing)",0,80,unavailable,3.1,2.3,3,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000186976,EFCAB6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.062782,-0.0588031,-0.106105
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000187003,ACTL7A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000187003,ACTL7A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000187003,ACTL7A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187005,KRTAP21-1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187005,KRTAP21-1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187005,KRTAP21-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,125.7,33.3,89.6,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); skin: 89.6 nTPM (manageable, limit 30); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 2); bone marrow: 27.6 nTPM (vital, limit 6); colon: 27.3 nTPM (protected, limit 2); parathyroid gland: 26 nTPM (protected, limit 2); cerebellum: 20.5 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); adrenal gland: 5.5 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187017,ESPN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.2432% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.6202% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 87.2986% (minimum 99%, Baseline (adaptation disabled)); colon: 83.7693% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.4747% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.8840% (minimum 97%, Baseline (adaptation disabled)); kidney: 69.6146% (minimum 99%, Baseline (adaptation disabled)); liver: 52.8507% (minimum 99%, Baseline (adaptation disabled)); lung: 97.8472% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.4218% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.5028% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.5254% (minimum 97%, Baseline (adaptation disabled)); retina: 55.1900% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.9333% (minimum 97%, Baseline (adaptation disabled)); skin: 61.1280% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.7712% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,125.7,33.3,89.6,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); skin: 89.6 nTPM (manageable, limit 5); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 2); bone marrow: 27.6 nTPM (vital, limit 1); colon: 27.3 nTPM (protected, limit 2); parathyroid gland: 26 nTPM (protected, limit 2); cerebellum: 20.5 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 2); rectum: 6.6 nTPM (protected, limit 2); adrenal gland: 5.5 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); pancreas: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187017,ESPN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.33872,-0.16116,-0.461493
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.2432% (minimum 99%, Missing); bone marrow: 83.6202% (minimum 95%, Enhanced); cerebellum: 87.2986% (minimum 99%, Missing); colon: 83.7693% (minimum 97%, Missing); duodenum: 61.4747% (minimum 99%, Missing); esophagus: 80.8840% (minimum 97%, Missing); kidney: 69.6146% (minimum 99%, Missing); liver: 52.8507% (minimum 99%, Missing); parathyroid gland: 84.4218% (minimum 97%, Missing); pituitary gland: 77.5028% (minimum 99%, Missing); rectum: 95.5254% (minimum 97%, Missing); retina: 55.1900% (minimum 99%, Missing); small intestine: 61.7712% (minimum 99%, Missing)",0,3,partial,125.7,33.3,89.6,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); skin: 89.6 nTPM (manageable, limit 30); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 2); bone marrow: 27.6 nTPM (vital, limit 6); colon: 27.3 nTPM (protected, limit 2); parathyroid gland: 26 nTPM (protected, limit 2); cerebellum: 20.5 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 2); adrenal gland: 5.5 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187017,ESPN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0112798,-0.16116,-0.461493
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,26,14.1,24,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); skin: 24 nTPM (manageable, limit 5); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (manageable, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (manageable, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 2); urinary bladder: 12.5 nTPM (protected, limit 2); lung: 12.3 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); colon: 11.7 nTPM (protected, limit 2); salivary gland: 11.2 nTPM (protected, limit 2); spinal cord: 10.1 nTPM (vital, limit 1); esophagus: 10.1 nTPM (protected, limit 2); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); tongue: 3.1 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187024,PTRH1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 51.2121% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 40.6250% (minimum 99%, Baseline (adaptation disabled)); amygdala: 46.1749% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 50.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.4762% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.6047% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 47.4719% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.8253% (minimum 99%, Baseline (adaptation disabled)); colon: 59.0909% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.4762% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.5926% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 48.8439% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.7508% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 52.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 39.3939% (minimum 99%, Baseline (adaptation disabled)); liver: 48.9855% (minimum 99%, Baseline (adaptation disabled)); lung: 57.8767% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.0796% (minimum 97%, Baseline (adaptation disabled)); midbrain: 50.2976% (minimum 99%, Baseline (adaptation disabled)); pancreas: 45.4301% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.8347% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 49.4152% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.4817% (minimum 97%, Baseline (adaptation disabled)); retina: 86.2245% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.1423% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 46.8144% (minimum 99%, Baseline (adaptation disabled)); skin: 41.3203% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.5473% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.2512% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.5926% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.8767% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.5161% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.8612% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 46.4286% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.5000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.4830% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,26,14.1,24,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); skin: 24 nTPM (manageable, limit 5); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (manageable, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (manageable, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 2); urinary bladder: 12.5 nTPM (protected, limit 2); lung: 12.3 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); colon: 11.7 nTPM (protected, limit 2); salivary gland: 11.2 nTPM (protected, limit 2); spinal cord: 10.1 nTPM (vital, limit 1); esophagus: 10.1 nTPM (protected, limit 2); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); tongue: 3.1 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187024,PTRH1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.536797,-0.424839,-0.596061
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 51.2121% (minimum 95%, Missing); adrenal gland: 40.6250% (minimum 99%, Missing); amygdala: 46.1749% (minimum 99%, Missing); basal ganglia: 50.0000% (minimum 99%, Missing); bone marrow: 80.4762% (minimum 99%, Missing); cerebellum: 78.6047% (minimum 99%, Missing); cerebral cortex: 47.4719% (minimum 99%, Missing); choroid plexus: 62.8253% (minimum 99%, Missing); colon: 59.0909% (minimum 97%, Missing); duodenum: 80.4762% (minimum 99%, Missing); esophagus: 62.5926% (minimum 97%, Missing); heart muscle: 48.8439% (minimum 99%, Missing); hippocampal formation: 50.7508% (minimum 99%, Missing); hypothalamus: 52.0000% (minimum 99%, Missing); kidney: 39.3939% (minimum 99%, Missing); liver: 48.9855% (minimum 99%, Missing); lung: 57.8767% (minimum 99%, Missing); lymph node: 84.0796% (minimum 97%, Missing); midbrain: 50.2976% (minimum 99%, Missing); pancreas: 45.4301% (minimum 99%, Missing); parathyroid gland: 69.8347% (minimum 97%, Missing); pituitary gland: 49.4152% (minimum 99%, Missing); rectum: 88.4817% (minimum 97%, Missing); retina: 86.2245% (minimum 99%, Missing); salivary gland: 60.1423% (minimum 97%, Missing); skeletal muscle: 46.8144% (minimum 99%, Missing); skin: 41.3203% (minimum 95%, Missing); small intestine: 69.5473% (minimum 99%, Missing); smooth muscle: 83.2512% (minimum 99%, Missing); spinal cord: 62.5926% (minimum 99%, Missing); spleen: 57.8767% (minimum 95%, Missing); stomach: 54.5161% (minimum 97%, Missing); thymus: 80.8612% (minimum 95%, Missing); thyroid gland: 46.4286% (minimum 95%, Missing); tongue: 84.5000% (minimum 97%, Missing); urinary bladder: 57.4830% (minimum 97%, Missing)",0,6,partial,26,14.1,24,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); skin: 24 nTPM (manageable, limit 5); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (manageable, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (manageable, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 2); urinary bladder: 12.5 nTPM (protected, limit 2); lung: 12.3 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); colon: 11.7 nTPM (protected, limit 2); salivary gland: 11.2 nTPM (protected, limit 2); spinal cord: 10.1 nTPM (vital, limit 1); esophagus: 10.1 nTPM (protected, limit 2); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 2); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 2); tongue: 3.1 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187024,PTRH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.536797,-0.424839,-0.596061
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,1.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187026,KRTAP21-2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 55.1724% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,1.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187026,KRTAP21-2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.398276,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 55.1724% (minimum 95%, Missing)",0,80,unavailable,0,0,1.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187026,KRTAP21-2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.398276,0.03,0.01
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,130,0.2,0,"retina: 130 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,ENSG00000187033,SAMD7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"lymph node: 33.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 0.0769% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,130,0.2,0,"retina: 130 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,ENSG00000187033,SAMD7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.636667,-0.989231
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"lymph node: 33.3333% (minimum 97%, Missing); retina: 0.0769% (minimum 99%, Missing)",0,80,unavailable,130,0.2,0,"retina: 130 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,ENSG00000187033,SAMD7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.636667,-0.989231
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187066,TMEM262,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187066,TMEM262,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0451456,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187066,TMEM262,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0451456,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000187080,OR2AK2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 33.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000187080,OR2AK2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.656667
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 33.3333% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000187080,OR2AK2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.656667
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000187082,DEFB106B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000187082,DEFB106B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000187082,DEFB106B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,2.8,1.5,3.4,"retina: 2.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000187105,HEATR4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.5217% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.6897% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.0678% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.2773% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.7328% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.7355% (minimum 99%, Baseline (adaptation disabled)); colon: 96.5217% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.0465% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.6897% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.6897% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.8718% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.6897% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.5217% (minimum 99%, Baseline (adaptation disabled)); liver: 93.2773% (minimum 99%, Baseline (adaptation disabled)); lung: 95.6897% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.0952% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.5217% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.2773% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.6897% (minimum 99%, Baseline (adaptation disabled)); retina: 79.8561% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.2773% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.0465% (minimum 99%, Baseline (adaptation disabled)); skin: 76.5517% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.0678% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.6897% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.5000% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.0678% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.5000% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,2.8,1.5,3.4,"retina: 2.8 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000187105,HEATR4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.184483,-0.0890476,-0.191439
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.6897% (minimum 99%, Missing); basal ganglia: 94.0678% (minimum 99%, Missing); bone marrow: 93.2773% (minimum 95%, Enhanced); cerebellum: 84.7328% (minimum 95%, Enhanced); cerebral cortex: 91.7355% (minimum 95%, Enhanced); colon: 96.5217% (minimum 97%, Missing); duodenum: 86.0465% (minimum 95%, Enhanced); hippocampal formation: 94.8718% (minimum 99%, Missing); hypothalamus: 95.6897% (minimum 99%, Missing); kidney: 96.5217% (minimum 99%, Missing); liver: 93.2773% (minimum 95%, Enhanced); lymph node: 88.0952% (minimum 97%, Missing); midbrain: 96.5217% (minimum 99%, Missing); pancreas: 93.2773% (minimum 95%, Enhanced); pituitary gland: 95.6897% (minimum 99%, Missing); retina: 79.8561% (minimum 99%, Missing); skeletal muscle: 86.0465% (minimum 95%, Enhanced); small intestine: 94.0678% (minimum 95%, Enhanced); spinal cord: 95.6897% (minimum 99%, Missing); stomach: 94.0678% (minimum 97%, Missing)",0,4,partial,2.8,1.5,3.4,"retina: 2.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000187105,HEATR4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,-0.0890476,-0.191439
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,33.9,0.5,2.4,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000187122,SLIT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.9524% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.4444% (minimum 99%, Baseline (adaptation disabled)); amygdala: 8.2524% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 6.8826% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.4737% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.9630% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 4.7753% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.2727% (minimum 99%, Baseline (adaptation disabled)); colon: 77.2727% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.4444% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.4444% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 7.8341% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 10.6250% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.4444% (minimum 99%, Baseline (adaptation disabled)); liver: 94.4444% (minimum 99%, Baseline (adaptation disabled)); lung: 89.4737% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.4444% (minimum 97%, Baseline (adaptation disabled)); midbrain: 23.6111% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.2727% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 11.4865% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.4444% (minimum 97%, Baseline (adaptation disabled)); retina: 70.8333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.4444% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.4444% (minimum 99%, Baseline (adaptation disabled)); small intestine: 89.4737% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.4444% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 45.9459% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.4737% (minimum 97%, Baseline (adaptation disabled)); thymus: 42.5000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 41.4634% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.4444% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,33.9,0.5,2.4,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000187122,SLIT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.535366,-0.197273,-0.942247
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.9524% (minimum 95%, Missing); adrenal gland: 94.4444% (minimum 99%, Missing); amygdala: 8.2524% (minimum 99%, Missing); basal ganglia: 6.8826% (minimum 99%, Missing); bone marrow: 89.4737% (minimum 99%, Missing); cerebellum: 62.9630% (minimum 99%, Missing); cerebral cortex: 4.7753% (minimum 99%, Missing); choroid plexus: 77.2727% (minimum 99%, Missing); colon: 77.2727% (minimum 97%, Missing); duodenum: 94.4444% (minimum 99%, Missing); heart muscle: 94.4444% (minimum 99%, Missing); hippocampal formation: 7.8341% (minimum 99%, Missing); hypothalamus: 10.6250% (minimum 99%, Missing); kidney: 94.4444% (minimum 99%, Missing); liver: 94.4444% (minimum 99%, Missing); lung: 89.4737% (minimum 99%, Missing); lymph node: 94.4444% (minimum 97%, Missing); midbrain: 23.6111% (minimum 99%, Missing); pancreas: 77.2727% (minimum 99%, Missing); pituitary gland: 11.4865% (minimum 99%, Missing); rectum: 94.4444% (minimum 97%, Missing); retina: 70.8333% (minimum 99%, Missing); salivary gland: 94.4444% (minimum 97%, Missing); skeletal muscle: 94.4444% (minimum 99%, Missing); small intestine: 89.4737% (minimum 99%, Missing); smooth muscle: 94.4444% (minimum 99%, Missing); spinal cord: 45.9459% (minimum 99%, Missing); spleen: 85.0000% (minimum 95%, Missing); stomach: 89.4737% (minimum 97%, Missing); thymus: 42.5000% (minimum 95%, Missing); thyroid gland: 41.4634% (minimum 95%, Missing); urinary bladder: 94.4444% (minimum 97%, Missing)",0,80,unavailable,33.9,0.5,2.4,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000187122,SLIT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.535366,-0.197273,-0.942247
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000187144,SPATA21,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.5000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.6667% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.1039% (minimum 99%, Baseline (adaptation disabled)); liver: 96.1039% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.8718% (minimum 99%, Baseline (adaptation disabled)); retina: 90.2439% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.6667% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000187144,SPATA21,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.011039,0.0166667,-0.087561
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.6667% (minimum 99%, Missing); bone marrow: 92.5000% (minimum 99%, Missing); cerebellum: 92.5000% (minimum 99%, Missing); choroid plexus: 98.6667% (minimum 99%, Missing); duodenum: 96.1039% (minimum 99%, Missing); liver: 96.1039% (minimum 99%, Missing); pancreas: 94.8718% (minimum 99%, Missing); retina: 90.2439% (minimum 99%, Missing); small intestine: 98.6667% (minimum 99%, Missing); smooth muscle: 98.6667% (minimum 99%, Missing); spinal cord: 98.6667% (minimum 99%, Missing)",0,80,unavailable,0.8,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000187144,SPATA21,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.011039,0.0166667,-0.087561
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,False,,0,8,partial,0.7,0.4,0.3,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187166,H1-7,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0,8,partial,0.7,0.4,0.3,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187166,H1-7,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0485802,0.0281079,0.00669343
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0,8,partial,0.7,0.4,0.3,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187166,H1-7,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.049053,0.0281079,0.00669343
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,95.6,21.6,13.2,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 6); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 6); cerebellum: 33 nTPM (vital, limit 6); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 6); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 2); kidney: 14.2 nTPM (vital, limit 6); adrenal gland: 9.4 nTPM (vital, limit 6); pancreas: 8.5 nTPM (vital, limit 6); liver: 6.6 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187186,ENSG00000187186,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.7995% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.2260% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.8355% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.5997% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.0381% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.8597% (minimum 99%, Baseline (adaptation disabled)); colon: 96.7336% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.6810% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 91.3267% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.4458% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.7358% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.2429% (minimum 99%, Baseline (adaptation disabled)); liver: 97.7312% (minimum 99%, Baseline (adaptation disabled)); lung: 98.3057% (minimum 99%, Baseline (adaptation disabled)); midbrain: 85.9172% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.0970% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 82.8139% (minimum 99%, Baseline (adaptation disabled)); retina: 97.8321% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 88.9271% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5442% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.4148% (minimum 99%, Baseline (adaptation disabled)); tongue: 92.9389% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,95.6,21.6,13.2,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 1); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 1); cerebellum: 33 nTPM (vital, limit 1); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 1); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 2); kidney: 14.2 nTPM (vital, limit 1); thyroid gland: 13.2 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); adrenal gland: 9.4 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 2); salivary gland: 7.1 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); retina: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 2); stomach: 6.1 nTPM (protected, limit 2); adipose tissue: 5.8 nTPM (manageable, limit 5); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187186,ENSG00000187186,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.00563025,-0.0406113,-0.241645
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 83.2260% (minimum 99%, Missing); basal ganglia: 74.8355% (minimum 99%, Missing); cerebellum: 89.5997% (minimum 95%, Enhanced); cerebral cortex: 79.0381% (minimum 95%, Enhanced); choroid plexus: 90.8597% (minimum 99%, Missing); heart muscle: 91.3267% (minimum 95%, Enhanced); hippocampal formation: 83.4458% (minimum 99%, Missing); hypothalamus: 85.7358% (minimum 99%, Missing); midbrain: 85.9172% (minimum 99%, Missing); pituitary gland: 82.8139% (minimum 99%, Missing); retina: 97.8321% (minimum 99%, Missing); skeletal muscle: 88.9271% (minimum 95%, Enhanced); spinal cord: 91.4148% (minimum 99%, Missing); tongue: 92.9389% (minimum 97%, Missing)",0,2,partial,95.6,21.6,13.2,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 6); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 6); cerebellum: 33 nTPM (vital, limit 6); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 6); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 2); kidney: 14.2 nTPM (vital, limit 6); adrenal gland: 9.4 nTPM (vital, limit 6); pancreas: 8.5 nTPM (vital, limit 6); liver: 6.6 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187186,ENSG00000187186,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0426676,-0.0406113,-0.241645
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.6,2,3.1,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187187,ZNF546,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.4172% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.0189% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.1892% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.5443% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.3504% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.9876% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.8421% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.9577% (minimum 99%, Baseline (adaptation disabled)); colon: 86.8421% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.0588% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.6170% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.6154% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.8421% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.7143% (minimum 99%, Baseline (adaptation disabled)); liver: 78.5714% (minimum 99%, Baseline (adaptation disabled)); lung: 91.0345% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.6170% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.1892% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.0189% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.3504% (minimum 97%, Baseline (adaptation disabled)); retina: 85.1613% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.4110% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.6154% (minimum 99%, Baseline (adaptation disabled)); skin: 92.9577% (minimum 95%, Baseline (adaptation disabled)); small intestine: 88.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.0345% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.9816% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.4110% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.9577% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.1613% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.0345% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.8421% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.6,2,3.1,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187187,ZNF546,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.140184,-0.101579,-0.204286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.4172% (minimum 95%, Missing); adrenal gland: 83.0189% (minimum 99%, Missing); amygdala: 89.1892% (minimum 99%, Missing); basal ganglia: 83.5443% (minimum 99%, Missing); bone marrow: 96.3504% (minimum 99%, Missing); cerebellum: 81.9876% (minimum 99%, Missing); cerebral cortex: 86.8421% (minimum 99%, Missing); choroid plexus: 92.9577% (minimum 99%, Missing); colon: 86.8421% (minimum 97%, Missing); duodenum: 97.0588% (minimum 99%, Missing); esophagus: 93.6170% (minimum 97%, Missing); heart muscle: 84.6154% (minimum 99%, Missing); hippocampal formation: 86.8421% (minimum 99%, Missing); hypothalamus: 88.0000% (minimum 99%, Missing); kidney: 85.7143% (minimum 99%, Missing); liver: 78.5714% (minimum 99%, Missing); lung: 91.0345% (minimum 99%, Missing); lymph node: 93.6170% (minimum 97%, Missing); midbrain: 89.1892% (minimum 99%, Missing); pancreas: 88.0000% (minimum 99%, Missing); parathyroid gland: 91.6667% (minimum 97%, Missing); pituitary gland: 83.0189% (minimum 99%, Missing); rectum: 96.3504% (minimum 97%, Missing); retina: 85.1613% (minimum 99%, Missing); salivary gland: 90.4110% (minimum 97%, Missing); skeletal muscle: 84.6154% (minimum 99%, Missing); skin: 92.9577% (minimum 95%, Missing); small intestine: 88.0000% (minimum 99%, Missing); smooth muscle: 91.0345% (minimum 99%, Missing); spinal cord: 88.0000% (minimum 99%, Missing); spleen: 80.9816% (minimum 95%, Missing); stomach: 90.4110% (minimum 97%, Missing); thymus: 92.9577% (minimum 95%, Missing); thyroid gland: 85.1613% (minimum 95%, Missing); tongue: 91.0345% (minimum 97%, Missing); urinary bladder: 86.8421% (minimum 97%, Missing)",0,80,unavailable,3.6,2,3.1,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187187,ZNF546,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.140184,-0.101579,-0.204286
True,compatible,,True,True,False,,0,1,partial,0,0.6,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187191,DAZ3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 82.3529% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.0000% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,0,0.6,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187191,DAZ3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,-0.126471,-0.27,0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 82.3529% (minimum 90%, Approved); stomach: 70.0000% (minimum 95%, Approved)",0,1,partial,0,0.6,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187191,DAZ3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,-0.0764706,-0.25,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.1,0,147.2,"skin: 147.2 nTPM (manageable, limit 5); skeletal muscle: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,ENSG00000187223,LCE2D,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 98.5507% (minimum 99%, Baseline (adaptation disabled)); liver: 95.7746% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 76.4045% (minimum 99%, Baseline (adaptation disabled)); skin: 4.4156% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2.1,0,147.2,"skin: 147.2 nTPM (manageable, limit 5); skeletal muscle: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,ENSG00000187223,LCE2D,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.905844,0.03,-0.225955
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 98.5507% (minimum 99%, Missing); liver: 95.7746% (minimum 99%, Missing); skeletal muscle: 76.4045% (minimum 99%, Missing); skin: 4.4156% (minimum 95%, Missing)",0,80,unavailable,2.1,0,147.2,"skin: 147.2 nTPM (manageable, limit 5); skeletal muscle: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,ENSG00000187223,LCE2D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.905844,0.03,-0.225955
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.9,0.2,37.2,"spleen: 37.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000187268,FAM9C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.4545% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 82.3529% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6744% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.4545% (minimum 97%, Baseline (adaptation disabled)); pancreas: 93.3333% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.6744% (minimum 99%, Baseline (adaptation disabled)); spleen: 10.1449% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.9,0.2,37.2,"spleen: 37.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000187268,FAM9C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.848551,-0.0154545,-0.166471
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.3333% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); heart muscle: 82.3529% (minimum 99%, Missing); lung: 97.6744% (minimum 99%, Missing); lymph node: 95.4545% (minimum 97%, Missing); pancreas: 93.3333% (minimum 99%, Missing); small intestine: 97.6744% (minimum 99%, Missing); spleen: 10.1449% (minimum 95%, Missing)",0,80,unavailable,0.9,0.2,37.2,"spleen: 37.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000187268,FAM9C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,-0.848551,-0.0154545,-0.166471
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.9,1.4,1.8,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187372,PCDHB13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.6923% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 55.5556% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.4286% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.7500% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.5000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.6923% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.7500% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.1818% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.7241% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.2174% (minimum 99%, Baseline (adaptation disabled)); liver: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 65.2174% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.9474% (minimum 99%, Baseline (adaptation disabled)); pancreas: 44.1176% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 68.1818% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 51.7241% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.4286% (minimum 97%, Baseline (adaptation disabled)); retina: 55.5556% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.7241% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.9474% (minimum 99%, Baseline (adaptation disabled)); skin: 45.4545% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.9474% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.4286% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.2174% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.1818% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.7500% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.2174% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.1818% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.2174% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.9,1.4,1.8,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187372,PCDHB13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.495455,-0.452759,-0.548824
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.6923% (minimum 95%, Missing); adrenal gland: 55.5556% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 71.4286% (minimum 99%, Missing); bone marrow: 93.7500% (minimum 99%, Missing); cerebellum: 62.5000% (minimum 99%, Missing); cerebral cortex: 57.6923% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 93.7500% (minimum 99%, Missing); esophagus: 68.1818% (minimum 97%, Missing); heart muscle: 51.7241% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 65.2174% (minimum 99%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 65.2174% (minimum 99%, Missing); lymph node: 83.3333% (minimum 97%, Missing); midbrain: 78.9474% (minimum 99%, Missing); pancreas: 44.1176% (minimum 99%, Missing); parathyroid gland: 68.1818% (minimum 97%, Missing); pituitary gland: 51.7241% (minimum 99%, Missing); rectum: 71.4286% (minimum 97%, Missing); retina: 55.5556% (minimum 99%, Missing); salivary gland: 51.7241% (minimum 97%, Missing); skeletal muscle: 78.9474% (minimum 99%, Missing); skin: 45.4545% (minimum 95%, Missing); small intestine: 78.9474% (minimum 99%, Missing); smooth muscle: 53.5714% (minimum 99%, Missing); spinal cord: 71.4286% (minimum 99%, Missing); spleen: 65.2174% (minimum 95%, Missing); stomach: 68.1818% (minimum 97%, Missing); thymus: 93.7500% (minimum 95%, Missing); thyroid gland: 65.2174% (minimum 95%, Missing); tongue: 68.1818% (minimum 97%, Missing); urinary bladder: 65.2174% (minimum 97%, Missing)",0,80,unavailable,1.9,1.4,1.8,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187372,PCDHB13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.495455,-0.452759,-0.548824
True,compatible,family_exclusion,True,True,False,,0,1,partial,0.1,0,0,,,54,not_established,required,in_situ_inflammation_review,appendix,ENSG00000187475,H1-6,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;family_exclusion,True,True,True,"choroid plexus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); liver: 90.9091% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 90.9091% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.1,0,0,,,54,not_established,required,in_situ_inflammation_review,appendix,ENSG00000187475,H1-6,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.0809091
False,excluded,reproductive_selectivity_below_threshold;family_exclusion,True,True,True,"choroid plexus: 90.9091% (minimum 99%, Missing); liver: 90.9091% (minimum 95%, Enhanced); skeletal muscle: 90.9091% (minimum 95%, Enhanced)",0,1,partial,0.1,0,0,,,54,not_established,required,in_situ_inflammation_review,appendix,ENSG00000187475,H1-6,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.0809091
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,366,232.2,462.7,"adipose tissue: 462.7 nTPM (manageable, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 2); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 2); colon: 145.8 nTPM (protected, limit 2); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (manageable, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); skin: 94 nTPM (manageable, limit 5); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); pancreas: 58.8 nTPM (vital, limit 1); spleen: 53.1 nTPM (manageable, limit 5); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 2); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 2); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); rectum: 8.1 nTPM (protected, limit 2); lymph node: 6.6 nTPM (protected, limit 2); bone marrow: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000187479,C11orf96,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0456% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.9955% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.5002% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.6606% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.4204% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.2075% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.8620% (minimum 99%, Baseline (adaptation disabled)); colon: 83.2587% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.4466% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.3404% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 73.5918% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.2325% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.2539% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.7708% (minimum 99%, Baseline (adaptation disabled)); liver: 80.5756% (minimum 99%, Baseline (adaptation disabled)); lung: 66.4559% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.8081% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.4990% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 85.4869% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 87.1410% (minimum 99%, Baseline (adaptation disabled)); skin: 88.5240% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.1556% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.3588% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.0589% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.1766% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.7443% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 86.2393% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 80.9625% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,366,232.2,462.7,"adipose tissue: 462.7 nTPM (manageable, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 2); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 2); colon: 145.8 nTPM (protected, limit 2); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (manageable, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); skin: 94 nTPM (manageable, limit 5); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); pancreas: 58.8 nTPM (vital, limit 1); spleen: 53.1 nTPM (manageable, limit 5); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 2); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 2); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); rectum: 8.1 nTPM (protected, limit 2); lymph node: 6.6 nTPM (protected, limit 2); bone marrow: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000187479,C11orf96,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.339544,-0.212557,-0.325441
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0456% (minimum 95%, Missing); adrenal gland: 78.9955% (minimum 99%, Missing); amygdala: 94.5002% (minimum 99%, Missing); basal ganglia: 94.6606% (minimum 99%, Missing); cerebellum: 97.4204% (minimum 99%, Missing); cerebral cortex: 95.2075% (minimum 99%, Missing); choroid plexus: 95.8620% (minimum 99%, Missing); colon: 83.2587% (minimum 97%, Missing); duodenum: 97.4466% (minimum 99%, Missing); esophagus: 94.3404% (minimum 97%, Uncertain); heart muscle: 73.5918% (minimum 99%, Missing); hippocampal formation: 95.2325% (minimum 99%, Missing); hypothalamus: 90.2539% (minimum 99%, Missing); kidney: 76.7708% (minimum 99%, Missing); liver: 80.5756% (minimum 99%, Missing); lung: 66.4559% (minimum 99%, Missing); midbrain: 91.8081% (minimum 99%, Missing); pancreas: 92.4990% (minimum 99%, Missing); pituitary gland: 85.4869% (minimum 99%, Missing); skeletal muscle: 87.1410% (minimum 99%, Uncertain); skin: 88.5240% (minimum 95%, Missing); small intestine: 85.1556% (minimum 99%, Missing); smooth muscle: 96.3588% (minimum 99%, Missing); spinal cord: 94.0589% (minimum 99%, Missing); spleen: 93.1766% (minimum 95%, Missing); stomach: 75.7443% (minimum 97%, Missing); thyroid gland: 86.2393% (minimum 95%, Missing); urinary bladder: 80.9625% (minimum 97%, Missing)",0,4,partial,366,232.2,462.7,"adipose tissue: 462.7 nTPM (manageable, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 2); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 2); colon: 145.8 nTPM (protected, limit 2); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (manageable, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); skin: 94 nTPM (manageable, limit 5); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); pancreas: 58.8 nTPM (vital, limit 1); spleen: 53.1 nTPM (manageable, limit 5); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 2); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 2); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 2); rectum: 8.1 nTPM (protected, limit 2); lymph node: 6.6 nTPM (protected, limit 2); bone marrow: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000187479,C11orf96,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.339544,-0.212557,-0.325441
True,compatible,,True,True,False,,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187516,H2AP,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187516,H2AP,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0453596,0.03,0.00767442
True,compatible,,True,True,True,,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000187516,H2AP,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00767442
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,2,partial,1.1,1071.7,0,"salivary gland: 1071.7 nTPM (protected, limit 2)",salivary gland / glandular cells: High (Enhanced),54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; salivary gland / glandular cells,ENSG00000187533,PRR27,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 83.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); pancreas: 31.2500% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 0.0466% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,1.1,1071.7,0,"salivary gland: 1071.7 nTPM (protected, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; salivary gland / glandular cells,ENSG00000187533,PRR27,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,-0.969534,-0.6775
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 83.3333% (minimum 95%, Enhanced); heart muscle: 71.4286% (minimum 95%, Enhanced); pancreas: 31.2500% (minimum 95%, Enhanced); salivary gland: 0.0466% (minimum 97%, Missing)",0,2,partial,1.1,1071.7,0,"salivary gland: 1071.7 nTPM (protected, limit 2)",salivary gland / glandular cells: High (Enhanced),54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; salivary gland / glandular cells,ENSG00000187533,PRR27,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,-0.969534,-0.6375
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187537,POTEG,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187537,POTEG,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187537,POTEG,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000187569,DPPA3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.8750% (minimum 99%, Baseline (adaptation disabled)); duodenum: 93.9394% (minimum 99%, Baseline (adaptation disabled)); lung: 86.1111% (minimum 99%, Baseline (adaptation disabled)); retina: 96.8750% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.8750% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000187569,DPPA3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.01875,-0.00125,-0.128889
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.8750% (minimum 99%, Missing); duodenum: 93.9394% (minimum 99%, Missing); lung: 86.1111% (minimum 99%, Missing); retina: 96.8750% (minimum 99%, Missing); stomach: 96.8750% (minimum 97%, Missing)",0,80,unavailable,0.5,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000187569,DPPA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.01875,-0.00125,-0.128889
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,0.4,0.1,0,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node / germinal center cells; skin 1 / fibroblasts; skin 2 / epidermal cells; tonsil / germinal center cells,ENSG00000187581,COX8C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0,5,partial,0.4,0.1,0,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node / germinal center cells; skin 1 / fibroblasts; skin 2 / epidermal cells; tonsil / germinal center cells,ENSG00000187581,COX8C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0286523,0.00463087
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0,5,partial,0.4,0.1,0,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node / germinal center cells; skin 1 / fibroblasts; skin 2 / epidermal cells; tonsil / germinal center cells,ENSG00000187581,COX8C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0286523,0.00730821
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,15,13.9,12.6,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 2); thymus: 12.6 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 2); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); lymph node: 8.6 nTPM (protected, limit 2); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.5 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); stomach: 5.1 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187607,ZNF286A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 74.3961% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.9565% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.9858% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.6842% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.7927% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 69.6833% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.5319% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.5439% (minimum 99%, Baseline (adaptation disabled)); colon: 73.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.6283% (minimum 99%, Baseline (adaptation disabled)); esophagus: 61.3546% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 50.6579% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.6422% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.2489% (minimum 99%, Baseline (adaptation disabled)); liver: 79.3814% (minimum 99%, Baseline (adaptation disabled)); lung: 75.8621% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.1667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 67.5439% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.7927% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.5597% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.6842% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 57.4627% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 76.2376% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 79.3814% (minimum 99%, Baseline (adaptation disabled)); skin: 73.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.6283% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.2308% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.6000% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.6842% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.1220% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.3922% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.0968% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.1667% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,15,13.9,12.6,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 2); thymus: 12.6 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 2); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); lymph node: 8.6 nTPM (protected, limit 2); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.5 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); stomach: 5.1 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187607,ZNF286A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4,-0.444403,-0.483421
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 74.3961% (minimum 95%, Missing); adrenal gland: 66.9565% (minimum 99%, Missing); amygdala: 72.9858% (minimum 99%, Missing); basal ganglia: 73.6842% (minimum 99%, Missing); bone marrow: 79.7927% (minimum 99%, Missing); cerebellum: 69.6833% (minimum 99%, Missing); cerebral cortex: 65.5319% (minimum 99%, Missing); choroid plexus: 67.5439% (minimum 99%, Missing); colon: 73.3333% (minimum 97%, Missing); duodenum: 80.6283% (minimum 99%, Missing); esophagus: 61.3546% (minimum 97%, Missing); heart muscle: 50.6579% (minimum 99%, Missing); hippocampal formation: 70.6422% (minimum 99%, Missing); hypothalamus: 73.3333% (minimum 99%, Missing); kidney: 67.2489% (minimum 99%, Missing); liver: 79.3814% (minimum 99%, Missing); lung: 75.8621% (minimum 99%, Missing); lymph node: 64.1667% (minimum 97%, Missing); midbrain: 67.5439% (minimum 99%, Missing); pancreas: 79.7927% (minimum 99%, Missing); parathyroid gland: 52.5597% (minimum 97%, Missing); pituitary gland: 73.6842% (minimum 99%, Missing); rectum: 77.0000% (minimum 97%, Missing); retina: 57.4627% (minimum 99%, Missing); salivary gland: 76.2376% (minimum 97%, Missing); skeletal muscle: 79.3814% (minimum 99%, Missing); skin: 73.3333% (minimum 95%, Missing); small intestine: 80.6283% (minimum 99%, Missing); smooth muscle: 59.2308% (minimum 99%, Missing); spinal cord: 61.6000% (minimum 99%, Missing); spleen: 73.6842% (minimum 95%, Missing); stomach: 75.1220% (minimum 97%, Missing); thymus: 55.0000% (minimum 95%, Missing); thyroid gland: 60.3922% (minimum 95%, Missing); tongue: 62.0968% (minimum 97%, Missing); urinary bladder: 64.1667% (minimum 97%, Missing)",0,80,unavailable,15,13.9,12.6,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 2); thymus: 12.6 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 2); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 2); urinary bladder: 8.6 nTPM (protected, limit 2); lymph node: 8.6 nTPM (protected, limit 2); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.5 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); stomach: 5.1 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); rectum: 4.6 nTPM (protected, limit 2); liver: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187607,ZNF286A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4,-0.444403,-0.483421
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,9.8,3.9,6.7,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 2); colon: 3.9 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 2); esophagus: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187624,LIAT1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.9614% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.7959% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.3731% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.7910% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.5455% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.1951% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.1095% (minimum 99%, Baseline (adaptation disabled)); colon: 93.6170% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.7910% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.8590% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.0789% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.5149% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.7301% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.4618% (minimum 99%, Baseline (adaptation disabled)); liver: 95.6522% (minimum 99%, Baseline (adaptation disabled)); lung: 95.4925% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.9614% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.3333% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.7851% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 89.3750% (minimum 99%, Baseline (adaptation disabled)); retina: 95.6522% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0166% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.7066% (minimum 99%, Baseline (adaptation disabled)); skin: 94.0789% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.9732% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.5455% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.1747% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 89.5149% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.6522% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,9.8,3.9,6.7,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187624,LIAT1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0548513,-0.0338298,-0.136269
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.9614% (minimum 99%, Missing); amygdala: 89.7959% (minimum 99%, Missing); basal ganglia: 85.3731% (minimum 99%, Missing); cerebellum: 94.5455% (minimum 98%, Approved); cerebral cortex: 87.1951% (minimum 99%, Missing); choroid plexus: 92.1095% (minimum 99%, Missing); colon: 93.6170% (minimum 97%, Missing); duodenum: 98.7910% (minimum 99%, Missing); esophagus: 94.8590% (minimum 97%, Missing); heart muscle: 94.0789% (minimum 99%, Missing); hippocampal formation: 89.5149% (minimum 99%, Missing); hypothalamus: 87.7301% (minimum 99%, Missing); kidney: 87.4618% (minimum 99%, Missing); liver: 95.6522% (minimum 99%, Missing); lung: 95.4925% (minimum 99%, Missing); midbrain: 91.9614% (minimum 99%, Missing); pancreas: 95.3333% (minimum 99%, Missing); parathyroid gland: 96.7851% (minimum 97%, Missing); pituitary gland: 89.3750% (minimum 99%, Missing); retina: 95.6522% (minimum 99%, Missing); salivary gland: 95.0166% (minimum 97%, Missing); skeletal muscle: 92.7066% (minimum 98%, Approved); small intestine: 95.9732% (minimum 99%, Missing); spinal cord: 94.5455% (minimum 99%, Missing); stomach: 95.1747% (minimum 97%, Missing); thyroid gland: 89.5149% (minimum 95%, Missing); urinary bladder: 95.6522% (minimum 97%, Missing)",0,3,partial,9.8,3.9,6.7,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 2); colon: 3.9 nTPM (protected, limit 2); heart muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 2); esophagus: 3.1 nTPM (protected, limit 2); salivary gland: 3 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187624,LIAT1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0548513,-0.0338298,-0.136269
True,compatible,,True,True,False,,0,80,unavailable,0.7,1.7,0,,,0,not_established,not_triggered,,,ENSG00000187658,C5orf52,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"colon: 95.3552% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.3099% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.9444% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.0337% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,1.7,0,,,0,not_established,not_triggered,,,ENSG00000187658,C5orf52,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,-0.0164481,-0.00966292
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"colon: 95.3552% (minimum 97%, Missing); duodenum: 98.3099% (minimum 99%, Missing); rectum: 96.9444% (minimum 97%, Missing); small intestine: 98.0337% (minimum 99%, Missing)",0,80,unavailable,0.7,1.7,0,,,0,not_established,not_triggered,,,ENSG00000187658,C5orf52,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,-0.0164481,-0.00966292
True,compatible,,True,True,False,,0,2,partial,1.6,0.1,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000187690,EZHIP,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.6102% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.4426% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.0822% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.9355% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.6102% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.6102% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.6102% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2759% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 85.0746% (minimum 99%, Baseline (adaptation disabled)); retina: 96.6102% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.6102% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.6102% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.9355% (minimum 95%, Baseline (adaptation disabled))",0,2,partial,1.6,0.1,0.5,"cerebellum: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000187690,EZHIP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0306452,0.0127586,-0.209178
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 95.0000% (minimum 99%, Missing); basal ganglia: 93.4426% (minimum 99%, Missing); cerebellum: 78.0822% (minimum 95%, Enhanced); choroid plexus: 91.9355% (minimum 99%, Missing); hippocampal formation: 95.0000% (minimum 99%, Missing); hypothalamus: 95.0000% (minimum 99%, Missing); midbrain: 96.6102% (minimum 99%, Missing); pituitary gland: 85.0746% (minimum 99%, Missing); retina: 96.6102% (minimum 99%, Missing); spinal cord: 96.6102% (minimum 99%, Missing)",0,2,partial,1.6,0.1,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000187690,EZHIP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.05,0.03,-0.169178
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,26.1,2,1.2,"choroid plexus: 26.1 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000187726,DNAJB13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.9868% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.9032% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.1288% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.3660% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.8484% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.7249% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.3704% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2824% (minimum 99%, Baseline (adaptation disabled)); lung: 94.4954% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.2617% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.4704% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.9087% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.8435% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8484% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,26.1,2,1.2,"choroid plexus: 26.1 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000187726,DNAJB13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0272296,-0.00738318,-0.32634
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 96.9868% (minimum 99%, Missing); basal ganglia: 95.9032% (minimum 99%, Missing); bone marrow: 92.1288% (minimum 95%, Enhanced); choroid plexus: 66.3660% (minimum 99%, Missing); hippocampal formation: 95.7249% (minimum 99%, Missing); hypothalamus: 95.3704% (minimum 99%, Missing); lung: 94.4954% (minimum 95%, Enhanced); pituitary gland: 97.9087% (minimum 99%, Missing); small intestine: 94.8435% (minimum 95%, Enhanced); spinal cord: 98.8484% (minimum 99%, Missing)",0,6,partial,26.1,2,1.2,"choroid plexus: 26.1 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000187726,DNAJB13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,0.03,-0.32634
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,16.5,13.6,9.9,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 2); adipose tissue: 9.9 nTPM (manageable, limit 5); rectum: 8.7 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); skin: 8.2 nTPM (manageable, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 2); duodenum: 6.8 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); smooth muscle: 6.2 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187736,NHEJ1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.7761% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.3900% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.4865% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.6561% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 71.1111% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.2105% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 54.0541% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.1754% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.5652% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.7273% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.6561% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.7696% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.1404% (minimum 99%, Baseline (adaptation disabled)); liver: 66.9456% (minimum 99%, Baseline (adaptation disabled)); lung: 70.4846% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.1174% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.1064% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.1157% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.7696% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.5615% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.7773% (minimum 97%, Baseline (adaptation disabled)); retina: 85.1064% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.4186% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 49.2308% (minimum 99%, Baseline (adaptation disabled)); skin: 66.1157% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.5540% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.0721% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.2183% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.4846% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.7773% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.1174% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.0488% (minimum 95%, Baseline (adaptation disabled)); tongue: 72.0721% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.3027% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,16.5,13.6,9.9,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 2); adipose tissue: 9.9 nTPM (manageable, limit 5); rectum: 8.7 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); skin: 8.2 nTPM (manageable, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 2); duodenum: 6.8 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); smooth muscle: 6.2 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187736,NHEJ1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.332239,-0.429459,-0.497692
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.7761% (minimum 95%, Missing); adrenal gland: 66.3900% (minimum 99%, Missing); amygdala: 86.4865% (minimum 99%, Missing); basal ganglia: 84.6561% (minimum 99%, Missing); bone marrow: 83.3333% (minimum 99%, Missing); cerebellum: 71.1111% (minimum 99%, Missing); cerebral cortex: 84.2105% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 54.0541% (minimum 97%, Missing); duodenum: 70.1754% (minimum 99%, Missing); esophagus: 69.5652% (minimum 97%, Missing); heart muscle: 72.7273% (minimum 99%, Missing); hippocampal formation: 84.6561% (minimum 99%, Missing); hypothalamus: 83.7696% (minimum 99%, Missing); kidney: 56.1404% (minimum 99%, Missing); liver: 66.9456% (minimum 99%, Missing); lung: 70.4846% (minimum 99%, Missing); lymph node: 75.1174% (minimum 97%, Missing); midbrain: 85.1064% (minimum 99%, Missing); pancreas: 66.1157% (minimum 99%, Missing); parathyroid gland: 83.7696% (minimum 97%, Missing); pituitary gland: 85.5615% (minimum 99%, Missing); rectum: 64.7773% (minimum 97%, Missing); retina: 85.1064% (minimum 99%, Missing); salivary gland: 74.4186% (minimum 97%, Missing); skeletal muscle: 49.2308% (minimum 99%, Missing); skin: 66.1157% (minimum 95%, Missing); small intestine: 57.5540% (minimum 99%, Missing); smooth muscle: 72.0721% (minimum 99%, Missing); spinal cord: 81.2183% (minimum 99%, Missing); spleen: 70.4846% (minimum 95%, Missing); stomach: 64.7773% (minimum 97%, Missing); thymus: 75.1174% (minimum 95%, Missing); thyroid gland: 78.0488% (minimum 95%, Missing); tongue: 72.0721% (minimum 97%, Missing); urinary bladder: 61.3027% (minimum 97%, Missing)",0,1,partial,16.5,13.6,9.9,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 2); adipose tissue: 9.9 nTPM (manageable, limit 5); rectum: 8.7 nTPM (protected, limit 2); stomach: 8.7 nTPM (protected, limit 2); skin: 8.2 nTPM (manageable, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 2); duodenum: 6.8 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 2); smooth muscle: 6.2 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); thymus: 5.3 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000187736,NHEJ1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.332239,-0.429459,-0.497692
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.3,7.7,6.5,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 2); spleen: 6.5 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 2); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187741,FANCA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.7031% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.1053% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.9091% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.0155% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.1527% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.4198% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.1704% (minimum 99%, Baseline (adaptation disabled)); colon: 84.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.0656% (minimum 99%, Baseline (adaptation disabled)); esophagus: 76.6423% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.5946% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.2353% (minimum 99%, Baseline (adaptation disabled)); liver: 78.0669% (minimum 99%, Baseline (adaptation disabled)); lung: 86.7769% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.1707% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.0226% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.1053% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.7742% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.7031% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.6076% (minimum 97%, Baseline (adaptation disabled)); retina: 97.6744% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.3043% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.7742% (minimum 99%, Baseline (adaptation disabled)); skin: 87.1369% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.2453% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.1704% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.5946% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.3636% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.3617% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.3529% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 92.9204% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 93.7500% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.3,7.7,6.5,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 2); spleen: 6.5 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 2); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187741,FANCA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.186364,-0.238293,-0.339845
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7500% (minimum 95%, Missing); adrenal gland: 91.7031% (minimum 99%, Missing); amygdala: 92.1053% (minimum 99%, Missing); basal ganglia: 90.9091% (minimum 99%, Missing); bone marrow: 65.0155% (minimum 99%, Missing); cerebellum: 80.1527% (minimum 99%, Missing); cerebral cortex: 86.4198% (minimum 99%, Missing); choroid plexus: 94.1704% (minimum 99%, Missing); colon: 84.0000% (minimum 97%, Missing); duodenum: 86.0656% (minimum 99%, Missing); esophagus: 76.6423% (minimum 97%, Missing); heart muscle: 93.3333% (minimum 99%, Missing); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 94.5946% (minimum 99%, Missing); kidney: 88.2353% (minimum 99%, Missing); liver: 78.0669% (minimum 99%, Missing); lung: 86.7769% (minimum 99%, Missing); lymph node: 73.1707% (minimum 97%, Missing); midbrain: 95.0226% (minimum 99%, Missing); pancreas: 92.1053% (minimum 99%, Missing); parathyroid gland: 96.7742% (minimum 97%, Missing); pituitary gland: 91.7031% (minimum 99%, Missing); rectum: 88.6076% (minimum 97%, Missing); retina: 97.6744% (minimum 99%, Missing); salivary gland: 91.3043% (minimum 97%, Missing); skeletal muscle: 96.7742% (minimum 99%, Missing); skin: 87.1369% (minimum 95%, Missing); small intestine: 79.2453% (minimum 99%, Missing); smooth muscle: 94.1704% (minimum 99%, Missing); spinal cord: 94.5946% (minimum 99%, Missing); spleen: 76.3636% (minimum 95%, Missing); stomach: 89.3617% (minimum 97%, Missing); thymus: 82.3529% (minimum 95%, Missing); thyroid gland: 92.9204% (minimum 95%, Missing); urinary bladder: 93.7500% (minimum 97%, Missing)",0,80,unavailable,11.3,7.7,6.5,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 2); spleen: 6.5 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 2); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187741,FANCA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.186364,-0.238293,-0.339845
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.4,0.5,0.3,"bone marrow: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000187753,C9orf153,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.0392% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.2857% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.5222% (minimum 99%, Baseline (adaptation disabled)); retina: 97.0874% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.4,0.5,0.3,"bone marrow: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000187753,C9orf153,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0352217,0.00560976,-0.0971429
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.0392% (minimum 99%, Missing); bone marrow: 89.2857% (minimum 99%, Missing); cerebral cortex: 98.5222% (minimum 99%, Missing); retina: 97.0874% (minimum 99%, Missing)",0,80,unavailable,2.4,0.5,0.3,"bone marrow: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000187753,C9orf153,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0352217,0.00560976,-0.0971429
True,compatible,,True,True,False,,0,2,partial,0.6,0.3,0.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000187754,SSX7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 33.3333% (minimum 99%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 25.0000% (minimum 97%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 14.2857% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 25.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 25.0000% (minimum 95%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,0.6,0.3,0.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000187754,SSX7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.7,-0.72,-0.847143
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 98%, Approved); cerebral cortex: 33.3333% (minimum 98%, Approved); duodenum: 50.0000% (minimum 98%, Approved); esophagus: 25.0000% (minimum 95%, Approved); lung: 50.0000% (minimum 98%, Approved); lymph node: 50.0000% (minimum 95%, Approved); retina: 14.2857% (minimum 99%, Missing); salivary gland: 25.0000% (minimum 95%, Approved); skin: 25.0000% (minimum 90%, Approved); spleen: 50.0000% (minimum 90%, Approved); stomach: 50.0000% (minimum 95%, Approved)",0,2,partial,0.6,0.3,0.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000187754,SSX7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.65,-0.7,-0.847143
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,1.5,0.1,0.2,"retina: 1.5 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000187772,LIN28B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.6816% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,1.5,0.1,0.2,"retina: 1.5 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000187772,LIN28B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,0.0468454,0.0284202,-0.0131839
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.6816% (minimum 99%, Missing)",0,4,partial,1.5,0.1,0.2,"retina: 1.5 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000187772,LIN28B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,-0.0131839
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,2.4,0,0.4,"retina: 2.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000187775,DNAH17,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 96.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1818% (minimum 99%, Baseline (adaptation disabled)); retina: 69.2308% (minimum 99%, Baseline (adaptation disabled)); skin: 93.1034% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,2.4,0,0.4,"retina: 2.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000187775,DNAH17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0189655,0.03,-0.297692
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 99%, Missing)",0,1,partial,2.4,0,0.4,"retina: 2.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000187775,DNAH17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.297692
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.3,1.8,2.6,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187790,FANCM,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.2683% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.0411% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.3265% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.2785% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.0149% (minimum 99%, Baseline (adaptation disabled)); colon: 86.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.2500% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 86.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 84.4156% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.3133% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.8378% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.5263% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 89.0411% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 76.4706% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.2469% (minimum 99%, Baseline (adaptation disabled)); skin: 82.2785% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.4156% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.5263% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.5263% (minimum 99%, Baseline (adaptation disabled)); spleen: 79.2683% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.4286% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.2785% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.4156% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.3,1.8,2.6,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187790,FANCM,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.235714,-0.186867,-0.326735
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.2683% (minimum 95%, Missing); adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 89.0411% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 66.3265% (minimum 99%, Missing); cerebellum: 82.2785% (minimum 99%, Missing); cerebral cortex: 86.6667% (minimum 99%, Missing); choroid plexus: 97.0149% (minimum 99%, Missing); colon: 86.6667% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); esophagus: 81.2500% (minimum 97%, Missing); heart muscle: 83.3333% (minimum 99%, Missing); hippocampal formation: 86.6667% (minimum 99%, Missing); hypothalamus: 86.6667% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 86.6667% (minimum 99%, Missing); lung: 84.4156% (minimum 99%, Missing); lymph node: 78.3133% (minimum 97%, Missing); midbrain: 87.8378% (minimum 99%, Missing); pancreas: 86.6667% (minimum 99%, Missing); parathyroid gland: 85.5263% (minimum 97%, Missing); pituitary gland: 89.0411% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 76.4706% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 80.2469% (minimum 99%, Missing); skin: 82.2785% (minimum 95%, Missing); small intestine: 84.4156% (minimum 99%, Missing); smooth muscle: 85.5263% (minimum 99%, Missing); spinal cord: 85.5263% (minimum 99%, Missing); spleen: 79.2683% (minimum 95%, Missing); stomach: 86.6667% (minimum 97%, Missing); thymus: 71.4286% (minimum 95%, Missing); thyroid gland: 86.6667% (minimum 95%, Missing); tongue: 82.2785% (minimum 97%, Missing); urinary bladder: 84.4156% (minimum 97%, Missing)",0,80,unavailable,3.3,1.8,2.6,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187790,FANCM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.235714,-0.186867,-0.326735
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.7,0.5,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen,ENSG00000187791,SPATA31F3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 97.5694% (minimum 99%, Baseline (adaptation disabled)); retina: 97.5694% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.9437% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.5,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen,ENSG00000187791,SPATA31F3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0394366,0.0125175,-0.0143056
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 97.5694% (minimum 99%, Missing); retina: 97.5694% (minimum 99%, Missing); skeletal muscle: 98.9437% (minimum 99%, Missing)",0,80,unavailable,0.7,0.5,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen,ENSG00000187791,SPATA31F3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0394366,0.0125175,-0.0143056
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,2.1,1.8,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187792,ZNF70,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.4545% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.0930% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.4872% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.9574% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.8889% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.0930% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.4872% (minimum 99%, Baseline (adaptation disabled)); colon: 68.8889% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.4872% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.4872% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.3913% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.6098% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.6098% (minimum 99%, Baseline (adaptation disabled)); liver: 81.5789% (minimum 99%, Baseline (adaptation disabled)); lung: 72.0930% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.8889% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.5833% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.6154% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 65.9574% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.0930% (minimum 97%, Baseline (adaptation disabled)); retina: 51.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.7843% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.3571% (minimum 99%, Baseline (adaptation disabled)); skin: 73.8095% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.0930% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.9574% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.8095% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.4545% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.4545% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.0930% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 63.2653% (minimum 95%, Baseline (adaptation disabled)); tongue: 59.6154% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 70.4545% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,2.1,1.8,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187792,ZNF70,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.317347,-0.373846,-0.473333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.4545% (minimum 95%, Missing); adrenal gland: 72.0930% (minimum 99%, Missing); amygdala: 79.4872% (minimum 99%, Missing); basal ganglia: 77.5000% (minimum 99%, Missing); bone marrow: 65.9574% (minimum 99%, Missing); cerebellum: 68.8889% (minimum 99%, Missing); cerebral cortex: 72.0930% (minimum 99%, Missing); choroid plexus: 79.4872% (minimum 99%, Missing); colon: 68.8889% (minimum 97%, Missing); duodenum: 79.4872% (minimum 99%, Missing); esophagus: 79.4872% (minimum 97%, Missing); heart muscle: 67.3913% (minimum 99%, Missing); hippocampal formation: 75.6098% (minimum 99%, Missing); hypothalamus: 77.5000% (minimum 99%, Missing); kidney: 75.6098% (minimum 99%, Missing); liver: 81.5789% (minimum 99%, Missing); lung: 72.0930% (minimum 99%, Missing); lymph node: 68.8889% (minimum 97%, Missing); midbrain: 77.5000% (minimum 99%, Missing); pancreas: 64.5833% (minimum 99%, Missing); parathyroid gland: 59.6154% (minimum 97%, Missing); pituitary gland: 65.9574% (minimum 99%, Missing); rectum: 72.0930% (minimum 97%, Missing); retina: 51.6667% (minimum 99%, Missing); salivary gland: 60.7843% (minimum 97%, Missing); skeletal muscle: 55.3571% (minimum 99%, Missing); skin: 73.8095% (minimum 95%, Missing); small intestine: 72.0930% (minimum 99%, Missing); smooth muscle: 65.9574% (minimum 99%, Missing); spinal cord: 73.8095% (minimum 99%, Missing); spleen: 70.4545% (minimum 95%, Missing); stomach: 70.4545% (minimum 97%, Missing); thymus: 72.0930% (minimum 95%, Missing); thyroid gland: 63.2653% (minimum 95%, Missing); tongue: 59.6154% (minimum 97%, Missing); urinary bladder: 70.4545% (minimum 97%, Missing)",0,80,unavailable,2.9,2.1,1.8,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); tongue: 2.1 nTPM (protected, limit 2); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187792,ZNF70,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.317347,-0.373846,-0.473333
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187806,TMEM202,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187806,TMEM202,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187806,TMEM202,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.9,2.8,3.1,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187815,ZFP69,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.8148% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.9167% (minimum 99%, Baseline (adaptation disabled)); amygdala: 53.0303% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 52.2388% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.8148% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.3448% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.3448% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.8148% (minimum 99%, Baseline (adaptation disabled)); colon: 57.3770% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.0377% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.8148% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.3077% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.6875% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 64.8148% (minimum 99%, Baseline (adaptation disabled)); lung: 60.3448% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.5556% (minimum 97%, Baseline (adaptation disabled)); midbrain: 53.8462% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.3220% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.3220% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 72.9167% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.8148% (minimum 97%, Baseline (adaptation disabled)); retina: 63.6364% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 67.3077% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 56.4516% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.3448% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 47.2973% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.0303% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.6364% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.6875% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 63.6364% (minimum 95%, Baseline (adaptation disabled)); tongue: 81.3953% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.3770% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.9,2.8,3.1,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187815,ZFP69,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.419697,-0.414444,-0.517027
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.8148% (minimum 95%, Missing); adrenal gland: 72.9167% (minimum 99%, Missing); amygdala: 53.0303% (minimum 99%, Missing); basal ganglia: 52.2388% (minimum 99%, Missing); bone marrow: 64.8148% (minimum 99%, Missing); cerebellum: 60.3448% (minimum 99%, Missing); cerebral cortex: 60.3448% (minimum 99%, Missing); choroid plexus: 64.8148% (minimum 99%, Missing); colon: 57.3770% (minimum 97%, Missing); duodenum: 66.0377% (minimum 99%, Missing); esophagus: 64.8148% (minimum 97%, Missing); heart muscle: 67.3077% (minimum 99%, Missing); hippocampal formation: 54.6875% (minimum 99%, Missing); hypothalamus: 58.3333% (minimum 99%, Missing); kidney: 62.5000% (minimum 99%, Missing); liver: 64.8148% (minimum 99%, Missing); lung: 60.3448% (minimum 99%, Missing); lymph node: 55.5556% (minimum 97%, Missing); midbrain: 53.8462% (minimum 99%, Missing); pancreas: 59.3220% (minimum 99%, Missing); parathyroid gland: 59.3220% (minimum 97%, Missing); pituitary gland: 72.9167% (minimum 99%, Missing); rectum: 64.8148% (minimum 97%, Missing); retina: 63.6364% (minimum 99%, Missing); salivary gland: 67.3077% (minimum 97%, Missing); skeletal muscle: 87.5000% (minimum 99%, Missing); skin: 56.4516% (minimum 95%, Missing); small intestine: 60.3448% (minimum 99%, Missing); smooth muscle: 58.3333% (minimum 99%, Missing); spinal cord: 47.2973% (minimum 99%, Missing); spleen: 53.0303% (minimum 95%, Missing); stomach: 63.6364% (minimum 97%, Missing); thymus: 54.6875% (minimum 95%, Missing); thyroid gland: 63.6364% (minimum 95%, Missing); tongue: 81.3953% (minimum 97%, Missing); urinary bladder: 57.3770% (minimum 97%, Missing)",0,80,unavailable,3.9,2.8,3.1,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); lymph node: 2.8 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); pancreas: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187815,ZFP69,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.419697,-0.414444,-0.517027
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187833,C2orf78,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187833,C2orf78,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187833,C2orf78,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.2,2.2,3.5,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187860,CCDC157,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.3737% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.0130% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.6230% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.3798% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.7063% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 85.8974% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.2121% (minimum 99%, Baseline (adaptation disabled)); colon: 96.7509% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.3737% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.0573% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.4545% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.3503% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.7073% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.2357% (minimum 99%, Baseline (adaptation disabled)); liver: 96.7509% (minimum 99%, Baseline (adaptation disabled)); lung: 92.7336% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.7143% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.4676% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.0556% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.4138% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 84.5426% (minimum 99%, Baseline (adaptation disabled)); retina: 92.4138% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0355% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.4545% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.0573% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5294% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.0355% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.3662% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.0573% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 88.4488% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.7509% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.2,2.2,3.5,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187860,CCDC157,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0655116,-0.0458621,-0.177879
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.3737% (minimum 99%, Missing); amygdala: 87.0130% (minimum 99%, Missing); basal ganglia: 85.6230% (minimum 99%, Missing); bone marrow: 93.3798% (minimum 99%, Missing); cerebellum: 93.7063% (minimum 99%, Missing); cerebral cortex: 85.8974% (minimum 99%, Missing); choroid plexus: 81.2121% (minimum 99%, Missing); colon: 96.7509% (minimum 97%, Missing); duodenum: 95.3737% (minimum 99%, Missing); esophagus: 96.0573% (minimum 97%, Missing); heart muscle: 97.4545% (minimum 99%, Missing); hippocampal formation: 85.3503% (minimum 99%, Missing); hypothalamus: 81.7073% (minimum 99%, Missing); kidney: 90.2357% (minimum 99%, Missing); liver: 96.7509% (minimum 99%, Missing); lung: 92.7336% (minimum 99%, Missing); lymph node: 95.7143% (minimum 97%, Missing); midbrain: 91.4676% (minimum 99%, Missing); pancreas: 93.0556% (minimum 99%, Missing); parathyroid gland: 92.4138% (minimum 97%, Missing); pituitary gland: 84.5426% (minimum 99%, Missing); retina: 92.4138% (minimum 99%, Missing); salivary gland: 95.0355% (minimum 97%, Missing); skeletal muscle: 97.4545% (minimum 99%, Missing); small intestine: 96.0573% (minimum 99%, Missing); smooth muscle: 98.5294% (minimum 99%, Missing); spinal cord: 95.0355% (minimum 99%, Missing); spleen: 94.3662% (minimum 95%, Missing); stomach: 96.0573% (minimum 97%, Missing); thyroid gland: 88.4488% (minimum 95%, Missing); urinary bladder: 96.7509% (minimum 97%, Missing)",0,80,unavailable,6.2,2.2,3.5,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000187860,CCDC157,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0655116,-0.0458621,-0.177879
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187918,OR51I2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187918,OR51I2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000187918,OR51I2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000187969,ZCCHC13,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000187969,ZCCHC13,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000187969,ZCCHC13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,1.2,0.7,0.8,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000187987,ZSCAN23,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.5714% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.5714% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.6154% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 84.6154% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.6154% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.6154% (minimum 99%, Baseline (adaptation disabled)); lung: 84.6154% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.6154% (minimum 97%, Baseline (adaptation disabled)); pancreas: 78.5714% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.1111% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.5714% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.5714% (minimum 97%, Baseline (adaptation disabled)); retina: 47.8261% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.7500% (minimum 97%, Baseline (adaptation disabled)); skin: 91.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.6154% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.5714% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.6154% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.8947% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.6154% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,1.2,0.7,0.8,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000187987,ZSCAN23,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.371053,-0.358889,-0.511739
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Missing); adrenal gland: 78.5714% (minimum 99%, Missing); cerebellum: 78.5714% (minimum 99%, Missing); cerebral cortex: 84.6154% (minimum 99%, Missing); choroid plexus: 91.6667% (minimum 99%, Missing); colon: 84.6154% (minimum 97%, Missing); duodenum: 91.6667% (minimum 99%, Uncertain); esophagus: 91.6667% (minimum 97%, Missing); heart muscle: 84.6154% (minimum 99%, Missing); kidney: 84.6154% (minimum 99%, Missing); lung: 84.6154% (minimum 99%, Missing); lymph node: 84.6154% (minimum 97%, Uncertain); pancreas: 78.5714% (minimum 99%, Missing); parathyroid gland: 61.1111% (minimum 97%, Uncertain); pituitary gland: 78.5714% (minimum 99%, Missing); rectum: 78.5714% (minimum 97%, Missing); retina: 47.8261% (minimum 99%, Missing); salivary gland: 68.7500% (minimum 97%, Missing); skin: 91.6667% (minimum 95%, Missing); small intestine: 84.6154% (minimum 99%, Uncertain); smooth muscle: 78.5714% (minimum 99%, Missing); spinal cord: 91.6667% (minimum 99%, Missing); spleen: 78.5714% (minimum 95%, Uncertain); stomach: 91.6667% (minimum 97%, Missing); thymus: 84.6154% (minimum 95%, Missing); thyroid gland: 57.8947% (minimum 95%, Missing); tongue: 91.6667% (minimum 97%, Missing); urinary bladder: 84.6154% (minimum 97%, Missing)",0,2,partial,1.2,0.7,0.8,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000187987,ZSCAN23,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.371053,-0.358889,-0.511739
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000188032,C19orf67,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 98.4615% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.4615% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.4615% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.9697% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000188032,C19orf67,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Carter 2023;da Silva 2017,0.0346154,-0.00030303,-0.00538462
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 98.4615% (minimum 99%, Missing); pancreas: 98.4615% (minimum 99%, Missing); pituitary gland: 98.4615% (minimum 99%, Missing); stomach: 96.9697% (minimum 97%, Missing)",0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000188032,C19orf67,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Carter 2023;da Silva 2017,0.0346154,-0.00030303,-0.00538462
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2,2,2.3,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188033,ZNF490,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.9655% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.5556% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.0741% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.2821% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.8235% (minimum 99%, Baseline (adaptation disabled)); colon: 64.5161% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.5161% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.4286% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 54.0541% (minimum 99%, Baseline (adaptation disabled)); lung: 60.6061% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.9565% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.8235% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.6316% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.5161% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.9655% (minimum 99%, Baseline (adaptation disabled)); skin: 54.0541% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.9655% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 46.5116% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.5161% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.7805% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 47.6190% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.9655% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2,2,2.3,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188033,ZNF490,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.484884,-0.47,-0.49
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Missing); adrenal gland: 68.9655% (minimum 99%, Missing); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 80.0000% (minimum 99%, Missing); bone marrow: 55.5556% (minimum 99%, Missing); cerebellum: 74.0741% (minimum 99%, Missing); cerebral cortex: 51.2821% (minimum 99%, Missing); choroid plexus: 58.8235% (minimum 99%, Missing); colon: 64.5161% (minimum 97%, Missing); duodenum: 64.5161% (minimum 99%, Missing); esophagus: 71.4286% (minimum 97%, Missing); heart muscle: 71.4286% (minimum 99%, Missing); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 83.3333% (minimum 99%, Missing); kidney: 62.5000% (minimum 99%, Missing); liver: 54.0541% (minimum 99%, Missing); lung: 60.6061% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 86.9565% (minimum 99%, Missing); pancreas: 58.8235% (minimum 99%, Missing); parathyroid gland: 52.6316% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 62.5000% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 64.5161% (minimum 97%, Missing); skeletal muscle: 68.9655% (minimum 99%, Missing); skin: 54.0541% (minimum 95%, Missing); small intestine: 71.4286% (minimum 99%, Missing); smooth muscle: 68.9655% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 46.5116% (minimum 95%, Missing); stomach: 64.5161% (minimum 97%, Missing); thymus: 48.7805% (minimum 95%, Missing); thyroid gland: 47.6190% (minimum 95%, Missing); tongue: 66.6667% (minimum 97%, Missing); urinary bladder: 68.9655% (minimum 97%, Missing)",0,80,unavailable,2,2,2.3,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188033,ZNF490,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.484884,-0.47,-0.49
True,compatible,,True,True,False,,0,80,unavailable,0.4,0.3,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000188050,RNF133,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.4,0.3,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000188050,RNF133,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0451456,0.0227361,0.000338164
True,compatible,,True,True,True,,0,80,unavailable,0.4,0.3,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000188050,RNF133,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0451456,0.0227361,0.000338164
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12,7.1,8.2,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); salivary gland: 7.1 nTPM (protected, limit 2); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); heart muscle: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188092,GPR89B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.3540% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.1053% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 67.1053% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.2727% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.0778% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.1795% (minimum 99%, Baseline (adaptation disabled)); colon: 66.2338% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.4407% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.9682% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.9682% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 45.9459% (minimum 99%, Baseline (adaptation disabled)); liver: 59.3023% (minimum 99%, Baseline (adaptation disabled)); lung: 65.8065% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.9310% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.7500% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.3448% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.2727% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.4564% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.9268% (minimum 97%, Baseline (adaptation disabled)); retina: 83.6066% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.9595% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 54.5455% (minimum 99%, Baseline (adaptation disabled)); skin: 55.4348% (minimum 95%, Baseline (adaptation disabled)); small intestine: 59.6491% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.2655% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.9832% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.5497% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.1951% (minimum 97%, Baseline (adaptation disabled)); thymus: 79.6875% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.9189% (minimum 95%, Baseline (adaptation disabled)); tongue: 64.1509% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.5767% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,12,7.1,8.2,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); salivary gland: 7.1 nTPM (protected, limit 2); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); heart muscle: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188092,GPR89B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.395652,-0.380405,-0.530541
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.3540% (minimum 95%, Missing); adrenal gland: 60.0000% (minimum 99%, Missing); amygdala: 67.1053% (minimum 99%, Missing); basal ganglia: 67.1053% (minimum 99%, Missing); bone marrow: 77.2727% (minimum 99%, Missing); cerebellum: 60.0000% (minimum 99%, Missing); cerebral cortex: 61.0778% (minimum 99%, Missing); choroid plexus: 87.1795% (minimum 99%, Missing); colon: 66.2338% (minimum 97%, Missing); duodenum: 86.4407% (minimum 99%, Missing); esophagus: 64.9682% (minimum 97%, Missing); heart muscle: 64.9682% (minimum 99%, Missing); hippocampal formation: 68.0000% (minimum 99%, Missing); hypothalamus: 60.0000% (minimum 99%, Missing); kidney: 45.9459% (minimum 99%, Missing); liver: 59.3023% (minimum 99%, Missing); lung: 65.8065% (minimum 99%, Missing); lymph node: 87.9310% (minimum 97%, Missing); midbrain: 63.7500% (minimum 99%, Missing); pancreas: 70.3448% (minimum 99%, Missing); parathyroid gland: 77.2727% (minimum 97%, Missing); pituitary gland: 68.4564% (minimum 99%, Missing); rectum: 82.9268% (minimum 97%, Missing); retina: 83.6066% (minimum 99%, Missing); salivary gland: 58.9595% (minimum 97%, Missing); skeletal muscle: 54.5455% (minimum 99%, Missing); skin: 55.4348% (minimum 95%, Missing); small intestine: 59.6491% (minimum 99%, Missing); smooth muscle: 90.2655% (minimum 99%, Missing); spinal cord: 56.9832% (minimum 99%, Missing); spleen: 67.5497% (minimum 95%, Missing); stomach: 62.1951% (minimum 97%, Missing); thymus: 79.6875% (minimum 95%, Missing); thyroid gland: 68.9189% (minimum 95%, Missing); tongue: 64.1509% (minimum 97%, Missing); urinary bladder: 62.5767% (minimum 97%, Missing)",0,80,unavailable,12,7.1,8.2,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); salivary gland: 7.1 nTPM (protected, limit 2); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 2); urinary bladder: 6.1 nTPM (protected, limit 2); adipose tissue: 5.9 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 2); heart muscle: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 2); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 2); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); rectum: 2.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188092,GPR89B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.395652,-0.380405,-0.530541
True,compatible,,True,True,False,,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,ENSG00000188120,DAZ1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"stomach: 90.9091% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,ENSG00000188120,DAZ1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,-0.0609091,0.01
True,compatible,,True,True,True,,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,ENSG00000188120,DAZ1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.00909091,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,2.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000188155,KRTAP10-6,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"skin: 7.4074% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,2.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000188155,KRTAP10-6,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.875926,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"skin: 7.4074% (minimum 95%, Missing)",0,80,unavailable,0,0,2.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000188155,KRTAP10-6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.875926,0.03,0.01
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,1.3,0,0,"pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000188162,OTOG,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"basal ganglia: 88.8889% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 38.0952% (minimum 99%, Baseline (adaptation disabled)); retina: 61.5385% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.3,0,0,"pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000188162,OTOG,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.609048
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"basal ganglia: 88.8889% (minimum 99%, Missing); pituitary gland: 38.0952% (minimum 99%, Missing); retina: 61.5385% (minimum 99%, Missing)",0,80,unavailable,1.3,0,0,"pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000188162,OTOG,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.609048
True,compatible,,True,True,False,,0,3,partial,1.8,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000188163,CIMIP2A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 98.9950% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.3361% (minimum 99%, Baseline (adaptation disabled)); liver: 97.0443% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.5000% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.8,0.4,0.6,"liver: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000188163,CIMIP2A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0399497,0.0232773,-0.0195567
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 98.5000% (minimum 99%, Missing)",0,3,partial,1.8,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000188163,CIMIP2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.005
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,5.4,1.8,1.5,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188167,TMPPE,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.5882% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.7143% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 18.1818% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 54.5455% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.5882% (minimum 99%, Baseline (adaptation disabled)); colon: 57.1429% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.3077% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.3077% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 99%, Baseline (adaptation disabled)); liver: 70.5882% (minimum 99%, Baseline (adaptation disabled)); lung: 54.5455% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.1739% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.3077% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 40.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 50.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 30.7692% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.1579% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); skin: 52.1739% (minimum 95%, Baseline (adaptation disabled)); small intestine: 52.1739% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.3077% (minimum 99%, Baseline (adaptation disabled)); spleen: 44.4444% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.5455% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.1579% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,5.4,1.8,1.5,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188167,TMPPE,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.505556,-0.57,-0.808182
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 70.5882% (minimum 99%, Missing); amygdala: 85.7143% (minimum 99%, Missing); basal ganglia: 85.7143% (minimum 99%, Missing); bone marrow: 18.1818% (minimum 99%, Missing); cerebellum: 80.0000% (minimum 99%, Missing); cerebral cortex: 54.5455% (minimum 99%, Missing); choroid plexus: 70.5882% (minimum 99%, Missing); colon: 57.1429% (minimum 97%, Missing); duodenum: 50.0000% (minimum 99%, Missing); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); hippocampal formation: 92.3077% (minimum 99%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); liver: 70.5882% (minimum 99%, Missing); lung: 54.5455% (minimum 99%, Missing); lymph node: 52.1739% (minimum 97%, Missing); midbrain: 92.3077% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 40.0000% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); rectum: 50.0000% (minimum 97%, Missing); retina: 30.7692% (minimum 99%, Missing); salivary gland: 63.1579% (minimum 97%, Missing); skeletal muscle: 85.7143% (minimum 99%, Missing); skin: 52.1739% (minimum 95%, Missing); small intestine: 52.1739% (minimum 99%, Missing); smooth muscle: 60.0000% (minimum 98%, Approved); spinal cord: 92.3077% (minimum 99%, Missing); spleen: 44.4444% (minimum 95%, Missing); stomach: 48.0000% (minimum 97%, Missing); thymus: 75.0000% (minimum 95%, Missing); thyroid gland: 54.5455% (minimum 95%, Missing); tongue: 80.0000% (minimum 97%, Missing); urinary bladder: 63.1579% (minimum 97%, Missing)",0,1,partial,5.4,1.8,1.5,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188167,TMPPE,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.505556,-0.57,-0.808182
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,10.4,19.3,21.7,"thyroid gland: 21.7 nTPM (manageable, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 2); urinary bladder: 13.8 nTPM (protected, limit 2); lymph node: 11.8 nTPM (protected, limit 2); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); smooth muscle: 8.8 nTPM (vital, limit 1); adrenal gland: 8.5 nTPM (vital, limit 1); thymus: 8.2 nTPM (manageable, limit 5); stomach: 7.8 nTPM (protected, limit 2); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); spleen: 6.7 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 2); tongue: 5.6 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000188171,ZNF626,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.9104% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.0884% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.3061% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.3061% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.9593% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.3162% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.5915% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.6000% (minimum 99%, Baseline (adaptation disabled)); colon: 86.0082% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3036% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.6952% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.7500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.6557% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.9593% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.7732% (minimum 99%, Baseline (adaptation disabled)); liver: 79.7710% (minimum 99%, Baseline (adaptation disabled)); lung: 81.0078% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.9144% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.9593% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.4513% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.9900% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.0082% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.4477% (minimum 97%, Baseline (adaptation disabled)); retina: 74.6429% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.7246% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.9365% (minimum 99%, Baseline (adaptation disabled)); skin: 69.8997% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.0862% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.3704% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.3061% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.7246% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.8223% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.8213% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 49.0610% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.8679% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.2305% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,10.4,19.3,21.7,"thyroid gland: 21.7 nTPM (manageable, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 2); urinary bladder: 13.8 nTPM (protected, limit 2); lymph node: 11.8 nTPM (protected, limit 2); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); smooth muscle: 8.8 nTPM (vital, limit 1); adrenal gland: 8.5 nTPM (vital, limit 1); thymus: 8.2 nTPM (manageable, limit 5); stomach: 7.8 nTPM (protected, limit 2); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); spleen: 6.7 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 2); tongue: 5.6 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000188171,ZNF626,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45939,-0.4501,-0.322268
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.9104% (minimum 95%, Uncertain); adrenal gland: 71.0884% (minimum 99%, Missing); amygdala: 85.3061% (minimum 99%, Missing); basal ganglia: 85.3061% (minimum 99%, Missing); bone marrow: 84.9593% (minimum 99%, Missing); cerebellum: 89.3162% (minimum 99%, Missing); cerebral cortex: 73.5915% (minimum 99%, Missing); choroid plexus: 83.6000% (minimum 99%, Missing); colon: 86.0082% (minimum 97%, Missing); duodenum: 93.3036% (minimum 99%, Missing); esophagus: 77.6952% (minimum 97%, Missing); heart muscle: 68.7500% (minimum 99%, Missing); hippocampal formation: 85.6557% (minimum 99%, Missing); hypothalamus: 84.9593% (minimum 99%, Missing); kidney: 66.7732% (minimum 99%, Uncertain); liver: 79.7710% (minimum 99%, Uncertain); lung: 81.0078% (minimum 99%, Missing); lymph node: 63.9144% (minimum 97%, Uncertain); midbrain: 84.9593% (minimum 99%, Missing); pancreas: 75.4513% (minimum 99%, Missing); parathyroid gland: 51.9900% (minimum 97%, Missing); pituitary gland: 86.0082% (minimum 99%, Missing); rectum: 87.4477% (minimum 97%, Missing); retina: 74.6429% (minimum 99%, Missing); salivary gland: 75.7246% (minimum 97%, Missing); skeletal muscle: 82.9365% (minimum 99%, Missing); skin: 69.8997% (minimum 95%, Missing); small intestine: 90.0862% (minimum 99%, Missing); smooth muscle: 70.3704% (minimum 99%, Missing); spinal cord: 85.3061% (minimum 99%, Missing); spleen: 75.7246% (minimum 95%, Missing); stomach: 72.8223% (minimum 97%, Missing); thymus: 71.8213% (minimum 95%, Missing); thyroid gland: 49.0610% (minimum 95%, Missing); tongue: 78.8679% (minimum 97%, Missing); urinary bladder: 60.2305% (minimum 97%, Missing)",0,3,partial,10.4,19.3,21.7,"thyroid gland: 21.7 nTPM (manageable, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 2); urinary bladder: 13.8 nTPM (protected, limit 2); lymph node: 11.8 nTPM (protected, limit 2); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); smooth muscle: 8.8 nTPM (vital, limit 1); adrenal gland: 8.5 nTPM (vital, limit 1); thymus: 8.2 nTPM (manageable, limit 5); stomach: 7.8 nTPM (protected, limit 2); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 2); spleen: 6.7 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 2); tongue: 5.6 nTPM (protected, limit 2); liver: 5.3 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); pituitary gland: 3.4 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000188171,ZNF626,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45939,-0.4501,-0.322268
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.5,5.3,8.6,"bone marrow: 11.5 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); retina: 4.9 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188295,ZNF669,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.6279% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.6479% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.3030% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.5385% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 31.5476% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.6341% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.3529% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.6479% (minimum 99%, Baseline (adaptation disabled)); colon: 59.5506% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.4321% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.8312% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.8312% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.3030% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.1045% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.5506% (minimum 99%, Baseline (adaptation disabled)); liver: 71.6216% (minimum 99%, Baseline (adaptation disabled)); lung: 62.3529% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.3030% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.3830% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 56.3830% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.9412% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.9195% (minimum 97%, Baseline (adaptation disabled)); retina: 51.9608% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.4321% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 73.6111% (minimum 99%, Baseline (adaptation disabled)); skin: 66.2500% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.7368% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.2273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.1045% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.6087% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.3529% (minimum 97%, Baseline (adaptation disabled)); thymus: 38.1295% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.4752% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.2273% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.0886% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.5,5.3,8.6,"bone marrow: 11.5 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); retina: 4.9 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188295,ZNF669,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.568705,-0.47,-0.674524
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.6279% (minimum 95%, Missing); adrenal gland: 74.6479% (minimum 99%, Missing); amygdala: 80.3030% (minimum 99%, Missing); basal ganglia: 81.5385% (minimum 99%, Missing); bone marrow: 31.5476% (minimum 99%, Missing); cerebellum: 64.6341% (minimum 99%, Missing); cerebral cortex: 62.3529% (minimum 99%, Missing); choroid plexus: 74.6479% (minimum 99%, Missing); colon: 59.5506% (minimum 97%, Missing); duodenum: 65.4321% (minimum 99%, Missing); esophagus: 68.8312% (minimum 97%, Missing); heart muscle: 68.8312% (minimum 99%, Missing); hippocampal formation: 80.3030% (minimum 99%, Missing); hypothalamus: 79.1045% (minimum 99%, Missing); kidney: 59.5506% (minimum 99%, Missing); liver: 71.6216% (minimum 99%, Missing); lung: 62.3529% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 80.3030% (minimum 99%, Missing); pancreas: 56.3830% (minimum 99%, Missing); parathyroid gland: 56.3830% (minimum 97%, Missing); pituitary gland: 77.9412% (minimum 99%, Missing); rectum: 60.9195% (minimum 97%, Missing); retina: 51.9608% (minimum 99%, Missing); salivary gland: 65.4321% (minimum 97%, Missing); skeletal muscle: 73.6111% (minimum 99%, Missing); skin: 66.2500% (minimum 95%, Missing); small intestine: 69.7368% (minimum 99%, Missing); smooth muscle: 60.2273% (minimum 99%, Missing); spinal cord: 79.1045% (minimum 99%, Missing); spleen: 57.6087% (minimum 95%, Missing); stomach: 62.3529% (minimum 97%, Missing); thymus: 38.1295% (minimum 95%, Missing); thyroid gland: 52.4752% (minimum 95%, Missing); tongue: 60.2273% (minimum 97%, Missing); urinary bladder: 67.0886% (minimum 97%, Missing)",0,80,unavailable,11.5,5.3,8.6,"bone marrow: 11.5 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 2); retina: 4.9 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 2); colon: 3.6 nTPM (protected, limit 2); kidney: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); rectum: 3.4 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); lung: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); duodenum: 2.8 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188295,ZNF669,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.568705,-0.47,-0.674524
True,compatible,,True,True,False,,0,80,unavailable,0.4,0.3,0,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland,ENSG00000188306,LRRIQ4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 96.5517% (minimum 99%, Baseline (adaptation disabled)); colon: 90.3226% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.5517% (minimum 97%, Baseline (adaptation disabled)); retina: 93.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.5517% (minimum 97%, Baseline (adaptation disabled)); small intestine: 87.5000% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.3333% (minimum 97%, Baseline (adaptation disabled)); tongue: 96.5517% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.3,0,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland,ENSG00000188306,LRRIQ4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,-0.0667742,-0.115
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 96.5517% (minimum 99%, Missing); colon: 90.3226% (minimum 97%, Missing); duodenum: 93.3333% (minimum 99%, Missing); rectum: 96.5517% (minimum 97%, Missing); retina: 93.3333% (minimum 99%, Missing); salivary gland: 96.5517% (minimum 97%, Missing); small intestine: 87.5000% (minimum 99%, Missing); stomach: 93.3333% (minimum 97%, Missing); tongue: 96.5517% (minimum 97%, Missing)",0,80,unavailable,0.4,0.3,0,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland,ENSG00000188306,LRRIQ4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,-0.0667742,-0.115
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,12.1,5.5,20.9,"skin: 20.9 nTPM (manageable, limit 5); bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); tongue: 4.3 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000188312,CENPP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 59.7222% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.3188% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.9041% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 26.2195% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.1515% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.5789% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.4894% (minimum 99%, Baseline (adaptation disabled)); colon: 65.1515% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.4286% (minimum 99%, Baseline (adaptation disabled)); esophagus: 50.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.4286% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 59.7222% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.2353% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.3548% (minimum 99%, Baseline (adaptation disabled)); liver: 70.4918% (minimum 99%, Baseline (adaptation disabled)); lung: 69.3548% (minimum 99%, Baseline (adaptation disabled)); lymph node: 43.8776% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.1791% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.1875% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.1515% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.3188% (minimum 97%, Baseline (adaptation disabled)); retina: 65.1515% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.1538% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 33.0769% (minimum 99%, Baseline (adaptation disabled)); skin: 17.0635% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.4918% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.7222% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.1875% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.4286% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.4918% (minimum 97%, Baseline (adaptation disabled)); thymus: 38.3929% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 76.7857% (minimum 95%, Baseline (adaptation disabled)); tongue: 50.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.1538% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,12.1,5.5,20.9,"skin: 20.9 nTPM (manageable, limit 5); bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); tongue: 4.3 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000188312,CENPP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.779365,-0.531224,-0.727805
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3333% (minimum 95%, Uncertain); adrenal gland: 59.7222% (minimum 99%, Missing); amygdala: 62.3188% (minimum 99%, Missing); basal ganglia: 58.9041% (minimum 99%, Missing); bone marrow: 26.2195% (minimum 99%, Missing); cerebellum: 65.1515% (minimum 99%, Missing); cerebral cortex: 56.5789% (minimum 99%, Missing); choroid plexus: 91.4894% (minimum 99%, Missing); colon: 65.1515% (minimum 97%, Missing); duodenum: 61.4286% (minimum 99%, Missing); esophagus: 50.0000% (minimum 97%, Missing); heart muscle: 61.4286% (minimum 99%, Uncertain); hippocampal formation: 59.7222% (minimum 99%, Missing); hypothalamus: 63.2353% (minimum 99%, Missing); kidney: 69.3548% (minimum 99%, Missing); liver: 70.4918% (minimum 99%, Missing); lung: 69.3548% (minimum 99%, Missing); lymph node: 43.8776% (minimum 97%, Uncertain); midbrain: 64.1791% (minimum 99%, Missing); pancreas: 67.1875% (minimum 99%, Missing); parathyroid gland: 65.1515% (minimum 97%, Missing); pituitary gland: 71.6667% (minimum 99%, Missing); rectum: 62.3188% (minimum 97%, Missing); retina: 65.1515% (minimum 99%, Missing); salivary gland: 66.1538% (minimum 97%, Missing); skeletal muscle: 33.0769% (minimum 99%, Missing); skin: 17.0635% (minimum 95%, Missing); small intestine: 70.4918% (minimum 99%, Missing); smooth muscle: 59.7222% (minimum 99%, Missing); spinal cord: 67.1875% (minimum 99%, Missing); spleen: 61.4286% (minimum 95%, Uncertain); stomach: 70.4918% (minimum 97%, Missing); thymus: 38.3929% (minimum 95%, Missing); thyroid gland: 76.7857% (minimum 95%, Missing); tongue: 50.0000% (minimum 97%, Missing); urinary bladder: 66.1538% (minimum 97%, Missing)",0,3,partial,12.1,5.5,20.9,"skin: 20.9 nTPM (manageable, limit 5); bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 2); tongue: 4.3 nTPM (protected, limit 2); esophagus: 4.3 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); salivary gland: 2.2 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000188312,CENPP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.779365,-0.531224,-0.727805
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,25.2,21.5,21.9,"pituitary gland: 25.2 nTPM (vital, limit 1); thymus: 21.9 nTPM (manageable, limit 5); spleen: 21.5 nTPM (manageable, limit 5); parathyroid gland: 21.5 nTPM (protected, limit 2); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); heart muscle: 19.1 nTPM (vital, limit 1); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 2); colon: 16.1 nTPM (protected, limit 2); lymph node: 15.6 nTPM (protected, limit 2); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 10); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 2); hypothalamus: 11 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 2); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188321,ZNF559,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.9130% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.8238% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.7554% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.5882% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.0449% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.7589% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.2500% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.6119% (minimum 99%, Baseline (adaptation disabled)); colon: 66.3180% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.6412% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.4910% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.4016% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.2389% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.2389% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.0219% (minimum 99%, Baseline (adaptation disabled)); liver: 74.5882% (minimum 99%, Baseline (adaptation disabled)); lung: 72.3744% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.0190% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.8373% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.4762% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 59.5865% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.7118% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.7642% (minimum 97%, Baseline (adaptation disabled)); retina: 61.5534% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.5400% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.3278% (minimum 99%, Baseline (adaptation disabled)); skin: 75.2969% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.7636% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.1474% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.6563% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.5865% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.5576% (minimum 97%, Baseline (adaptation disabled)); thymus: 59.1418% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.4016% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.6563% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.9044% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,25.2,21.5,21.9,"pituitary gland: 25.2 nTPM (vital, limit 1); thymus: 21.9 nTPM (manageable, limit 5); spleen: 21.5 nTPM (manageable, limit 5); parathyroid gland: 21.5 nTPM (protected, limit 2); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); heart muscle: 19.1 nTPM (vital, limit 1); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 2); colon: 16.1 nTPM (protected, limit 2); lymph node: 15.6 nTPM (protected, limit 2); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 2); hypothalamus: 11 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 2); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188321,ZNF559,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.358582,-0.374135,-0.432882
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.9130% (minimum 90%, Approved); adrenal gland: 69.8238% (minimum 99%, Missing); amygdala: 76.7554% (minimum 99%, Missing); basal ganglia: 74.5882% (minimum 99%, Missing); bone marrow: 89.0449% (minimum 99%, Missing); cerebellum: 70.7589% (minimum 99%, Missing); cerebral cortex: 79.2500% (minimum 99%, Missing); choroid plexus: 60.6119% (minimum 99%, Missing); colon: 66.3180% (minimum 97%, Missing); duodenum: 83.6412% (minimum 99%, Missing); esophagus: 81.4910% (minimum 97%, Missing); heart muscle: 62.4016% (minimum 99%, Missing); hippocampal formation: 74.2389% (minimum 99%, Missing); hypothalamus: 74.2389% (minimum 99%, Missing); kidney: 63.0219% (minimum 99%, Missing); liver: 74.5882% (minimum 99%, Missing); lung: 72.3744% (minimum 99%, Missing); lymph node: 67.0190% (minimum 97%, Missing); midbrain: 75.8373% (minimum 99%, Missing); pancreas: 75.4762% (minimum 99%, Missing); parathyroid gland: 59.5865% (minimum 97%, Missing); pituitary gland: 55.7118% (minimum 99%, Missing); rectum: 74.7642% (minimum 97%, Missing); retina: 61.5534% (minimum 99%, Missing); salivary gland: 72.5400% (minimum 97%, Missing); skeletal muscle: 87.3278% (minimum 99%, Missing); skin: 75.2969% (minimum 95%, Missing); small intestine: 68.7636% (minimum 99%, Missing); smooth muscle: 63.1474% (minimum 99%, Missing); spinal cord: 75.6563% (minimum 99%, Missing); spleen: 59.5865% (minimum 95%, Missing); stomach: 71.5576% (minimum 97%, Missing); thymus: 59.1418% (minimum 95%, Missing); thyroid gland: 62.4016% (minimum 95%, Missing); tongue: 75.6563% (minimum 97%, Missing); urinary bladder: 65.9044% (minimum 97%, Missing)",0,2,partial,25.2,21.5,21.9,"pituitary gland: 25.2 nTPM (vital, limit 1); thymus: 21.9 nTPM (manageable, limit 5); spleen: 21.5 nTPM (manageable, limit 5); parathyroid gland: 21.5 nTPM (protected, limit 2); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); heart muscle: 19.1 nTPM (vital, limit 1); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 2); colon: 16.1 nTPM (protected, limit 2); lymph node: 15.6 nTPM (protected, limit 2); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 10); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 2); lung: 12.1 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 2); hypothalamus: 11 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 2); skin: 10.4 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 2); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 2); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188321,ZNF559,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.358582,-0.374135,-0.432882
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,7.3,0,0,"retina: 7.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,ENSG00000188334,BSPH1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.0835% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,7.3,0,0,"retina: 7.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,ENSG00000188334,BSPH1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.00916514
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.0835% (minimum 99%, Missing)",0,1,partial,7.3,0,0,"retina: 7.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,ENSG00000188334,BSPH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.00916514
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.1,1.1,0.7,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188368,PRR19,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.4545% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.9091% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.6653% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.5172% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.5172% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.1288% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.8904% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.5915% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.0226% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.9204% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.2222% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2222% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5915% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.3303% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1308% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.8904% (minimum 99%, Baseline (adaptation disabled)); retina: 98.1308% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.7742% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.5915% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.1308% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5915% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.2222% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,4.1,1.1,0.7,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188368,PRR19,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0177419,-0.0197738,-0.153347
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.4545% (minimum 99%, Missing); amygdala: 90.9091% (minimum 99%, Missing); basal ganglia: 83.6653% (minimum 99%, Missing); bone marrow: 90.5172% (minimum 99%, Missing); cerebellum: 90.5172% (minimum 99%, Missing); cerebral cortex: 90.1288% (minimum 99%, Missing); choroid plexus: 95.8904% (minimum 99%, Missing); duodenum: 98.5915% (minimum 99%, Missing); esophagus: 95.0226% (minimum 97%, Missing); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 92.9204% (minimum 99%, Missing); kidney: 97.2222% (minimum 99%, Missing); liver: 97.2222% (minimum 99%, Missing); lung: 98.5915% (minimum 99%, Missing); midbrain: 96.3303% (minimum 99%, Missing); pancreas: 98.1308% (minimum 99%, Missing); pituitary gland: 95.8904% (minimum 99%, Missing); retina: 98.1308% (minimum 99%, Missing); salivary gland: 96.7742% (minimum 97%, Missing); skeletal muscle: 98.5915% (minimum 99%, Missing); small intestine: 98.1308% (minimum 99%, Missing); smooth muscle: 98.5915% (minimum 99%, Missing); spinal cord: 97.2222% (minimum 99%, Missing)",0,80,unavailable,4.1,1.1,0.7,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188368,PRR19,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.0177419,-0.0197738,-0.153347
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000188386,PPP3R2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000188386,PPP3R2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00872935
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000188386,PPP3R2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00872935
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,1.6,0.9,0.9,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000188394,GPR21,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 50.0000% (minimum 95%, Baseline (adaptation disabled)); amygdala: 69.2308% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.2857% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 36.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 81.8182% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.2857% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.8182% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.8182% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.8182% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.8182% (minimum 99%, Baseline (adaptation disabled)); lung: 81.8182% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.0000% (minimum 97%, Baseline (adaptation disabled)); rectum: 64.2857% (minimum 97%, Baseline (adaptation disabled)); retina: 69.2308% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 81.8182% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.8182% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.0000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 75.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.6,0.9,0.9,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000188394,GPR21,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.45,-0.47,-0.63
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 50.0000% (minimum 95%, Missing); amygdala: 69.2308% (minimum 99%, Missing); basal ganglia: 64.2857% (minimum 99%, Missing); bone marrow: 90.0000% (minimum 99%, Missing); cerebellum: 90.0000% (minimum 99%, Missing); cerebral cortex: 36.0000% (minimum 99%, Missing); colon: 81.8182% (minimum 97%, Missing); duodenum: 90.0000% (minimum 99%, Missing); esophagus: 64.2857% (minimum 97%, Missing); heart muscle: 81.8182% (minimum 99%, Missing); hippocampal formation: 81.8182% (minimum 99%, Missing); hypothalamus: 81.8182% (minimum 99%, Missing); kidney: 81.8182% (minimum 99%, Missing); lung: 81.8182% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 90.0000% (minimum 99%, Missing); parathyroid gland: 90.0000% (minimum 97%, Missing); rectum: 64.2857% (minimum 97%, Missing); retina: 69.2308% (minimum 99%, Missing); salivary gland: 90.0000% (minimum 97%, Missing); skeletal muscle: 90.0000% (minimum 99%, Missing); skin: 81.8182% (minimum 95%, Missing); small intestine: 90.0000% (minimum 99%, Missing); smooth muscle: 50.0000% (minimum 99%, Missing); spinal cord: 90.0000% (minimum 99%, Missing); spleen: 81.8182% (minimum 95%, Missing); stomach: 90.0000% (minimum 97%, Missing); thyroid gland: 75.0000% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,80,unavailable,1.6,0.9,0.9,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000188394,GPR21,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.45,-0.47,-0.63
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000188408,MAGEB5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000188408,MAGEB5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000188408,MAGEB5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,5,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000188425,NANOS2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 97.2222% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.2222% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.2222% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2222% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.2222% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000188425,NANOS2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0177778
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 97.2222% (minimum 99%, Missing); cerebral cortex: 97.2222% (minimum 98%, Approved); hippocampal formation: 97.2222% (minimum 99%, Missing); hypothalamus: 97.2222% (minimum 99%, Missing); midbrain: 97.2222% (minimum 99%, Missing)",0,5,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000188425,NANOS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0177778
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.6,0.1,8,"skin: 8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000188467,SLC24A5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 94.1176% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.1176% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.1176% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.1176% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.2105% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.1176% (minimum 99%, Baseline (adaptation disabled)); midbrain: 72.7273% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 84.2105% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.1176% (minimum 97%, Baseline (adaptation disabled)); skin: 16.6667% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 88.8889% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.1176% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.1,8,"skin: 8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000188467,SLC24A5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.783333,-0.0288235,-0.262727
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 94.1176% (minimum 99%, Missing); cerebellum: 88.8889% (minimum 99%, Missing); cerebral cortex: 94.1176% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); hippocampal formation: 94.1176% (minimum 99%, Missing); hypothalamus: 84.2105% (minimum 99%, Missing); kidney: 94.1176% (minimum 99%, Missing); midbrain: 72.7273% (minimum 99%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); retina: 84.2105% (minimum 99%, Missing); salivary gland: 94.1176% (minimum 97%, Missing); skin: 16.6667% (minimum 95%, Missing); spinal cord: 88.8889% (minimum 99%, Missing); stomach: 94.1176% (minimum 97%, Missing)",0,80,unavailable,0.6,0.1,8,"skin: 8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000188467,SLC24A5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.783333,-0.0288235,-0.262727
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.5,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000188558,OR2G6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 40.0000% (minimum 99%, Baseline (adaptation disabled)); duodenum: 50.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); pancreas: 40.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 28.5714% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 50.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000188558,OR2G6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.45,-0.47,-0.704286
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 66.6667% (minimum 99%, Missing); bone marrow: 40.0000% (minimum 99%, Missing); duodenum: 50.0000% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); pancreas: 40.0000% (minimum 99%, Missing); retina: 28.5714% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing); skeletal muscle: 66.6667% (minimum 99%, Missing); skin: 50.0000% (minimum 95%, Missing); small intestine: 66.6667% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 50.0000% (minimum 97%, Missing)",0,80,unavailable,0.5,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000188558,OR2G6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.45,-0.47,-0.704286
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.8,1.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000188585,CLEC20A,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 72.4138% (minimum 99%, Baseline (adaptation disabled)); lymph node: 65.6250% (minimum 97%, Baseline (adaptation disabled)); spleen: 80.7692% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.5000% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.3043% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.4545% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.8,1.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000188585,CLEC20A,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,-0.142308,-0.31375,-0.265862
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 72.4138% (minimum 99%, Missing); lymph node: 65.6250% (minimum 97%, Missing); spleen: 80.7692% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thymus: 91.3043% (minimum 95%, Missing); urinary bladder: 95.4545% (minimum 97%, Missing)",0,80,unavailable,0.8,1.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,ENSG00000188585,CLEC20A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,-0.142308,-0.31375,-0.265862
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,42.7,11.8,25.9,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (manageable, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 2); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188687,SLC4A5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.5882% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.6522% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.9024% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.5349% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.3529% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.7711% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 26.5060% (minimum 99%, Baseline (adaptation disabled)); colon: 93.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.6522% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.4785% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.7711% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.4785% (minimum 99%, Baseline (adaptation disabled)); liver: 94.4785% (minimum 99%, Baseline (adaptation disabled)); lung: 86.0335% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.0585% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.7711% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.1243% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 56.6176% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.0056% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.6522% (minimum 97%, Baseline (adaptation disabled)); retina: 27.5000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.5882% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.5349% (minimum 99%, Baseline (adaptation disabled)); skin: 76.6169% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.9024% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.0585% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.4785% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.9024% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 37.2881% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.1243% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 93.9024% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,42.7,11.8,25.9,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (manageable, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 2); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188687,SLC4A5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.577119,-0.403824,-0.72494
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.5882% (minimum 95%, Uncertain); adrenal gland: 95.6522% (minimum 99%, Uncertain); amygdala: 93.3333% (minimum 99%, Missing); basal ganglia: 93.9024% (minimum 99%, Missing); bone marrow: 89.5349% (minimum 99%, Uncertain); cerebellum: 82.3529% (minimum 99%, Missing); cerebral cortex: 92.7711% (minimum 99%, Uncertain); choroid plexus: 26.5060% (minimum 99%, Missing); colon: 93.3333% (minimum 97%, Missing); duodenum: 95.6522% (minimum 99%, Missing); esophagus: 94.4785% (minimum 97%, Missing); heart muscle: 91.6667% (minimum 99%, Uncertain); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 92.7711% (minimum 99%, Missing); kidney: 94.4785% (minimum 99%, Missing); liver: 94.4785% (minimum 99%, Uncertain); lung: 86.0335% (minimum 99%, Uncertain); lymph node: 90.0585% (minimum 97%, Uncertain); midbrain: 92.7711% (minimum 99%, Missing); pancreas: 91.1243% (minimum 99%, Missing); parathyroid gland: 56.6176% (minimum 97%, Missing); pituitary gland: 87.0056% (minimum 99%, Missing); rectum: 95.6522% (minimum 97%, Missing); retina: 27.5000% (minimum 99%, Missing); salivary gland: 90.5882% (minimum 97%, Missing); skeletal muscle: 89.5349% (minimum 99%, Uncertain); skin: 76.6169% (minimum 95%, Uncertain); small intestine: 93.9024% (minimum 99%, Missing); smooth muscle: 91.6667% (minimum 99%, Uncertain); spinal cord: 90.0585% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Uncertain); stomach: 94.4785% (minimum 97%, Missing); thymus: 93.9024% (minimum 95%, Missing); thyroid gland: 37.2881% (minimum 95%, Uncertain); tongue: 91.1243% (minimum 97%, Missing); urinary bladder: 93.9024% (minimum 97%, Missing)",0,1,partial,42.7,11.8,25.9,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (manageable, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 2); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188687,SLC4A5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.577119,-0.403824,-0.72494
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000188691,OR56A5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000188691,OR56A5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000188691,OR56A5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.6,2.5,0.2,"stomach: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,ENSG00000188738,FSIP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.2963% (minimum 99%, Baseline (adaptation disabled)); colon: 78.7879% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.1132% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.2963% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.5455% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.2459% (minimum 97%, Baseline (adaptation disabled)); retina: 89.6552% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.2963% (minimum 99%, Baseline (adaptation disabled)); stomach: 67.5325% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.2963% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.6,2.5,0.2,"stomach: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,ENSG00000188738,FSIP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019;Loriot 2025,0.012963,-0.294675,-0.0934483
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.2963% (minimum 99%, Missing); colon: 78.7879% (minimum 97%, Missing); pancreas: 98.1132% (minimum 99%, Missing); parathyroid gland: 96.2963% (minimum 97%, Missing); pituitary gland: 94.5455% (minimum 99%, Missing); rectum: 85.2459% (minimum 97%, Missing); retina: 89.6552% (minimum 99%, Missing); small intestine: 96.2963% (minimum 99%, Missing); stomach: 67.5325% (minimum 97%, Missing); urinary bladder: 96.2963% (minimum 97%, Missing)",0,80,unavailable,0.6,2.5,0.2,"stomach: 2.5 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,ENSG00000188738,FSIP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019;Loriot 2025,0.012963,-0.294675,-0.0934483
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,35,22.6,17.8,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 2); salivary gland: 19.4 nTPM (protected, limit 2); skeletal muscle: 19 nTPM (vital, limit 1); skin: 17.8 nTPM (manageable, limit 5); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); urinary bladder: 15.1 nTPM (protected, limit 2); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 2); rectum: 13.6 nTPM (protected, limit 2); esophagus: 13.4 nTPM (protected, limit 2); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 2); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188739,RBM34,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6923% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.6471% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.4969% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.1342% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 37.1634% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.9286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.1098% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.3099% (minimum 99%, Baseline (adaptation disabled)); colon: 63.1098% (minimum 97%, Baseline (adaptation disabled)); duodenum: 54.3307% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.7038% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.9832% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.2997% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.0867% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.6452% (minimum 99%, Baseline (adaptation disabled)); liver: 58.9744% (minimum 99%, Baseline (adaptation disabled)); lung: 64.2857% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.8060% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.6071% (minimum 99%, Baseline (adaptation disabled)); pancreas: 61.9760% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.6970% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.8904% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.3499% (minimum 97%, Baseline (adaptation disabled)); retina: 77.2388% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.6209% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 52.1411% (minimum 99%, Baseline (adaptation disabled)); skin: 53.7662% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.3407% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.8903% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.1429% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.5378% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.8266% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.5574% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.6602% (minimum 95%, Baseline (adaptation disabled)); tongue: 64.4860% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.8212% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,35,22.6,17.8,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 2); salivary gland: 19.4 nTPM (protected, limit 2); skeletal muscle: 19 nTPM (vital, limit 1); skin: 17.8 nTPM (manageable, limit 5); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); urinary bladder: 15.1 nTPM (protected, limit 2); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 2); rectum: 13.6 nTPM (protected, limit 2); esophagus: 13.4 nTPM (protected, limit 2); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 2); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188739,RBM34,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.412338,-0.49194,-0.618366
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6923% (minimum 95%, Missing); adrenal gland: 67.6471% (minimum 99%, Missing); amygdala: 63.4969% (minimum 99%, Missing); basal ganglia: 66.1342% (minimum 99%, Missing); bone marrow: 37.1634% (minimum 99%, Missing); cerebellum: 73.9286% (minimum 99%, Missing); cerebral cortex: 63.1098% (minimum 99%, Missing); choroid plexus: 58.3099% (minimum 99%, Missing); colon: 63.1098% (minimum 97%, Missing); duodenum: 54.3307% (minimum 99%, Missing); esophagus: 60.7038% (minimum 97%, Missing); heart muscle: 57.9832% (minimum 99%, Missing); hippocampal formation: 65.2997% (minimum 99%, Missing); hypothalamus: 64.0867% (minimum 99%, Missing); kidney: 55.6452% (minimum 99%, Missing); liver: 58.9744% (minimum 99%, Missing); lung: 64.2857% (minimum 99%, Missing); lymph node: 47.8060% (minimum 97%, Missing); midbrain: 61.6071% (minimum 99%, Missing); pancreas: 61.9760% (minimum 99%, Missing); parathyroid gland: 69.6970% (minimum 97%, Missing); pituitary gland: 70.8904% (minimum 99%, Missing); rectum: 60.3499% (minimum 97%, Missing); retina: 77.2388% (minimum 99%, Missing); salivary gland: 51.6209% (minimum 97%, Missing); skeletal muscle: 52.1411% (minimum 99%, Missing); skin: 53.7662% (minimum 95%, Missing); small intestine: 57.3407% (minimum 99%, Missing); smooth muscle: 64.8903% (minimum 99%, Missing); spinal cord: 59.1429% (minimum 99%, Missing); spleen: 62.5378% (minimum 95%, Missing); stomach: 59.8266% (minimum 97%, Missing); thymus: 56.5574% (minimum 95%, Missing); thyroid gland: 57.6602% (minimum 95%, Missing); tongue: 64.4860% (minimum 97%, Missing); urinary bladder: 57.8212% (minimum 97%, Missing)",0,6,partial,35,22.6,17.8,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 2); salivary gland: 19.4 nTPM (protected, limit 2); skeletal muscle: 19 nTPM (vital, limit 1); skin: 17.8 nTPM (manageable, limit 5); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); urinary bladder: 15.1 nTPM (protected, limit 2); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 2); rectum: 13.6 nTPM (protected, limit 2); esophagus: 13.4 nTPM (protected, limit 2); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 2); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 2); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 2); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188739,RBM34,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.412338,-0.49194,-0.618366
True,compatible,,True,True,False,,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,ENSG00000188782,CATSPER4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 98.1982% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,ENSG00000188782,CATSPER4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.00801802
True,compatible,,True,True,True,,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,ENSG00000188782,CATSPER4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000188784,PLA2G2E,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000188784,PLA2G2E,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000188784,PLA2G2E,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,25.9,23.2,18.4,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 2); spleen: 18.4 nTPM (manageable, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); thymus: 13 nTPM (manageable, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); skin: 10 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 2); urinary bladder: 8.1 nTPM (protected, limit 2); rectum: 7.9 nTPM (protected, limit 2); esophagus: 7.8 nTPM (protected, limit 2); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); pituitary gland: 6.9 nTPM (vital, limit 1); salivary gland: 6.9 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188785,ZNF548,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0356% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.3243% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.3165% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.4568% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 31.4815% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.1250% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.3908% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.6207% (minimum 99%, Baseline (adaptation disabled)); colon: 55.3488% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.3243% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.4061% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.6549% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.4568% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.3750% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.3846% (minimum 99%, Baseline (adaptation disabled)); liver: 64.3243% (minimum 99%, Baseline (adaptation disabled)); lung: 50.6383% (minimum 99%, Baseline (adaptation disabled)); lymph node: 33.9031% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.2821% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.3243% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.9109% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.2979% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.1010% (minimum 97%, Baseline (adaptation disabled)); retina: 49.3776% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.2979% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.9792% (minimum 99%, Baseline (adaptation disabled)); skin: 54.3379% (minimum 95%, Baseline (adaptation disabled)); small intestine: 45.5939% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 51.5152% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.1212% (minimum 99%, Baseline (adaptation disabled)); spleen: 39.2739% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.9630% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.7912% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 51.0730% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.1860% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.5000% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,25.9,23.2,18.4,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 2); spleen: 18.4 nTPM (manageable, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); thymus: 13 nTPM (manageable, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); skin: 10 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 2); urinary bladder: 8.1 nTPM (protected, limit 2); rectum: 7.9 nTPM (protected, limit 2); esophagus: 7.8 nTPM (protected, limit 2); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); pituitary gland: 6.9 nTPM (vital, limit 1); salivary gland: 6.9 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188785,ZNF548,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.557261,-0.630969,-0.675185
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0356% (minimum 95%, Uncertain); adrenal gland: 64.3243% (minimum 99%, Missing); amygdala: 75.3165% (minimum 99%, Missing); basal ganglia: 73.4568% (minimum 99%, Missing); bone marrow: 31.4815% (minimum 99%, Uncertain); cerebellum: 53.1250% (minimum 99%, Missing); cerebral cortex: 68.3908% (minimum 99%, Missing); choroid plexus: 58.6207% (minimum 99%, Missing); colon: 55.3488% (minimum 97%, Missing); duodenum: 64.3243% (minimum 99%, Missing); esophagus: 60.4061% (minimum 97%, Missing); heart muscle: 52.6549% (minimum 99%, Missing); hippocampal formation: 73.4568% (minimum 99%, Missing); hypothalamus: 74.3750% (minimum 99%, Missing); kidney: 65.3846% (minimum 99%, Missing); liver: 64.3243% (minimum 99%, Missing); lung: 50.6383% (minimum 99%, Missing); lymph node: 33.9031% (minimum 97%, Missing); midbrain: 76.2821% (minimum 99%, Missing); pancreas: 64.3243% (minimum 99%, Missing); parathyroid gland: 58.9109% (minimum 97%, Missing); pituitary gland: 63.2979% (minimum 99%, Missing); rectum: 60.1010% (minimum 97%, Missing); retina: 49.3776% (minimum 99%, Missing); salivary gland: 63.2979% (minimum 97%, Missing); skeletal muscle: 61.9792% (minimum 99%, Missing); skin: 54.3379% (minimum 95%, Missing); small intestine: 45.5939% (minimum 99%, Missing); smooth muscle: 51.5152% (minimum 99%, Missing); spinal cord: 72.1212% (minimum 99%, Missing); spleen: 39.2739% (minimum 95%, Missing); stomach: 62.9630% (minimum 97%, Missing); thymus: 47.7912% (minimum 95%, Missing); thyroid gland: 51.0730% (minimum 95%, Missing); tongue: 69.1860% (minimum 97%, Missing); urinary bladder: 59.5000% (minimum 97%, Missing)",0,3,partial,25.9,23.2,18.4,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 2); spleen: 18.4 nTPM (manageable, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); thymus: 13 nTPM (manageable, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); skin: 10 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 2); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 2); urinary bladder: 8.1 nTPM (protected, limit 2); rectum: 7.9 nTPM (protected, limit 2); esophagus: 7.8 nTPM (protected, limit 2); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 2); pituitary gland: 6.9 nTPM (vital, limit 1); salivary gland: 6.9 nTPM (protected, limit 2); liver: 6.6 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000188785,ZNF548,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.557261,-0.630969,-0.675185
True,compatible,,True,True,False,,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,ENSG00000188800,TMCO2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,ENSG00000188800,TMCO2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0291618,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,ENSG00000188800,TMCO2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0291618,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,1.7,1.1,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000188848,BEND4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.8085% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.8495% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.7895% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.8144% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9130% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.8085% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.8144% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9130% (minimum 99%, Baseline (adaptation disabled)); lung: 97.8495% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.2593% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.9192% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.0990% (minimum 99%, Baseline (adaptation disabled)); retina: 90.0990% (minimum 99%, Baseline (adaptation disabled)); small intestine: 89.2157% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.2157% (minimum 95%, Baseline (adaptation disabled)); thymus: 91.9192% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.1,1.7,1.1,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000188848,BEND4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.0578431,-0.127407,-0.0978431
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.8085% (minimum 99%, Missing); basal ganglia: 97.8495% (minimum 99%, Missing); bone marrow: 95.7895% (minimum 99%, Missing); cerebral cortex: 93.8144% (minimum 99%, Missing); duodenum: 98.9130% (minimum 99%, Missing); hippocampal formation: 96.8085% (minimum 99%, Missing); hypothalamus: 93.8144% (minimum 99%, Missing); liver: 98.9130% (minimum 99%, Missing); lung: 97.8495% (minimum 99%, Missing); lymph node: 84.2593% (minimum 97%, Missing); midbrain: 91.9192% (minimum 99%, Missing); pituitary gland: 90.0990% (minimum 99%, Missing); retina: 90.0990% (minimum 99%, Missing); small intestine: 89.2157% (minimum 99%, Missing); spleen: 89.2157% (minimum 95%, Missing); thymus: 91.9192% (minimum 95%, Missing)",0,80,unavailable,1.1,1.7,1.1,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000188848,BEND4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.0578431,-0.127407,-0.0978431
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.7,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000188859,FAM78B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 64.7059% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.6154% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.5714% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.6154% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.6154% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 68.7500% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.6154% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.7059% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.6154% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.6154% (minimum 99%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 99%, Baseline (adaptation disabled)); lung: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.3333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 68.7500% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 57.8947% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 84.6154% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.1111% (minimum 99%, Baseline (adaptation disabled)); skin: 68.7500% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.6154% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.6154% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.6154% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 78.5714% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.1111% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.7,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000188859,FAM78B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.302941,-0.358889,-0.411053
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 64.7059% (minimum 95%, Missing); adrenal gland: 84.6154% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 78.5714% (minimum 99%, Missing); cerebellum: 84.6154% (minimum 99%, Missing); cerebral cortex: 84.6154% (minimum 99%, Missing); choroid plexus: 91.6667% (minimum 99%, Missing); colon: 68.7500% (minimum 97%, Missing); duodenum: 84.6154% (minimum 99%, Missing); esophagus: 73.3333% (minimum 97%, Missing); heart muscle: 64.7059% (minimum 99%, Missing); hippocampal formation: 84.6154% (minimum 99%, Missing); hypothalamus: 91.6667% (minimum 99%, Missing); kidney: 84.6154% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Missing); lung: 91.6667% (minimum 99%, Missing); lymph node: 91.6667% (minimum 97%, Missing); midbrain: 91.6667% (minimum 99%, Missing); pancreas: 73.3333% (minimum 99%, Missing); pituitary gland: 68.7500% (minimum 99%, Missing); rectum: 91.6667% (minimum 97%, Missing); retina: 57.8947% (minimum 99%, Missing); salivary gland: 84.6154% (minimum 97%, Missing); skeletal muscle: 61.1111% (minimum 99%, Missing); skin: 68.7500% (minimum 95%, Missing); small intestine: 91.6667% (minimum 99%, Missing); smooth muscle: 84.6154% (minimum 99%, Missing); spleen: 84.6154% (minimum 95%, Missing); stomach: 84.6154% (minimum 97%, Missing); thyroid gland: 78.5714% (minimum 95%, Missing); tongue: 91.6667% (minimum 97%, Missing); urinary bladder: 61.1111% (minimum 97%, Missing)",0,80,unavailable,0.8,0.7,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000188859,FAM78B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.302941,-0.358889,-0.411053
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000188877,POTEA,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000188877,POTEA,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000188877,POTEA,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000188909,BSX,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"hypothalamus: 18.1818% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000188909,BSX,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.808182
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"hypothalamus: 18.1818% (minimum 99%, Missing)",0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000188909,BSX,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.808182
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,207.8,17.7,25.6,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 6); heart muscle: 38.2 nTPM (vital, limit 6); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 6); esophagus: 17.7 nTPM (protected, limit 12); kidney: 16.1 nTPM (vital, limit 6); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 6); adrenal gland: 12.9 nTPM (vital, limit 6); basal ganglia: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 12); hippocampal formation: 11.1 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 6); duodenum: 10.1 nTPM (vital, limit 6); liver: 9.7 nTPM (vital, limit 6); pancreas: 9.4 nTPM (vital, limit 6); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.5 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188931,CFAP126,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 92.9658% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.9173% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.5232% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.1482% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.0615% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.9725% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 41.3822% (minimum 99%, Baseline (adaptation disabled)); colon: 96.8317% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.5587% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.2336% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.3402% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.9658% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.7797% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.1106% (minimum 99%, Baseline (adaptation disabled)); liver: 93.7980% (minimum 99%, Baseline (adaptation disabled)); lung: 91.5730% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.1362% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.5232% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.9782% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.6698% (minimum 99%, Baseline (adaptation disabled)); retina: 82.1849% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.2642% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 64.3421% (minimum 99%, Baseline (adaptation disabled)); skin: 88.9091% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.1429% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1523% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.1979% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 85.1422% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.5767% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,207.8,17.7,25.6,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 1); heart muscle: 38.2 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); thyroid gland: 25.6 nTPM (manageable, limit 5); skin: 18.3 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 2); kidney: 16.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 1); adrenal gland: 12.9 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 2); adipose tissue: 11.1 nTPM (manageable, limit 5); hippocampal formation: 11.1 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); pancreas: 9.4 nTPM (vital, limit 1); midbrain: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); lymph node: 7.5 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); spleen: 6.2 nTPM (manageable, limit 5); urinary bladder: 5.2 nTPM (protected, limit 2); colon: 4.8 nTPM (protected, limit 2); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188931,CFAP126,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0985781,-0.0776642,-0.576178
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 91.9173% (minimum 95%, Enhanced); amygdala: 94.5232% (minimum 99%, Missing); basal ganglia: 92.1482% (minimum 99%, Missing); cerebral cortex: 83.9725% (minimum 95%, Enhanced); choroid plexus: 41.3822% (minimum 99%, Missing); duodenum: 93.5587% (minimum 95%, Enhanced); heart muscle: 79.3402% (minimum 95%, Enhanced); hippocampal formation: 92.9658% (minimum 99%, Missing); hypothalamus: 90.7797% (minimum 99%, Missing); kidney: 90.1106% (minimum 95%, Enhanced); liver: 93.7980% (minimum 95%, Enhanced); lung: 91.5730% (minimum 95%, Enhanced); midbrain: 94.5232% (minimum 99%, Missing); pancreas: 93.9782% (minimum 95%, Enhanced); pituitary gland: 97.6698% (minimum 99%, Missing); retina: 82.1849% (minimum 99%, Missing); skeletal muscle: 64.3421% (minimum 95%, Enhanced); small intestine: 93.1429% (minimum 95%, Enhanced); spinal cord: 97.1523% (minimum 99%, Missing)",0,4,partial,207.8,17.7,25.6,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 6); heart muscle: 38.2 nTPM (vital, limit 6); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 6); esophagus: 17.7 nTPM (protected, limit 12); kidney: 16.1 nTPM (vital, limit 6); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 6); adrenal gland: 12.9 nTPM (vital, limit 6); basal ganglia: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 12); hippocampal formation: 11.1 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 6); duodenum: 10.1 nTPM (vital, limit 6); liver: 9.7 nTPM (vital, limit 6); pancreas: 9.4 nTPM (vital, limit 6); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.5 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000188931,CFAP126,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.045251,0.0293188,-0.576178
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189023,MAGEB16,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189023,MAGEB16,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189023,MAGEB16,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,ENSG00000189037,DUSP21,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.1132% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.1132% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,ENSG00000189037,DUSP21,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0204762,-0.00886792
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.1132% (minimum 99%, Missing); small intestine: 98.1132% (minimum 99%, Missing)",0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,ENSG00000189037,DUSP21,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0204762,-0.00886792
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,8.4,0.3,0.4,"pituitary gland: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000189052,CGB5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bradley 2020;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 92.9104% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 74.7748% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,8.4,0.3,0.4,"pituitary gland: 8.4 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000189052,CGB5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bradley 2020;Gong 2021;da Silva 2017,0.0341897,0.0180952,-0.242252
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 92.9104% (minimum 97%, Supported); pituitary gland: 74.7748% (minimum 99%, Missing)",0,1,partial,8.4,0.3,0.4,"pituitary gland: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000189052,CGB5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bradley 2020;Gong 2021;da Silva 2017,0.05,0.03,-0.242252
True,compatible,,True,True,False,,0,4,partial,0.8,0,0,,,52,not_established,not_triggered,,,ENSG00000189064,GAGE2A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0.8,0,0,,,52,not_established,not_triggered,,,ENSG00000189064,GAGE2A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.00143469
True,compatible,,True,True,True,,0,4,partial,0.8,0,0,,,52,not_established,not_triggered,,,ENSG00000189064,GAGE2A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.00143469
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,18.1,41.9,"skin: 41.9 nTPM (manageable, limit 5); esophagus: 18.1 nTPM (protected, limit 2); salivary gland: 8.6 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,ENSG00000189090,FAM25G,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 35.8156% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 54.0107% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.0583% (minimum 99%, Baseline (adaptation disabled)); skin: 19.4231% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.3248% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.6,18.1,41.9,"skin: 41.9 nTPM (manageable, limit 5); esophagus: 18.1 nTPM (protected, limit 2); salivary gland: 8.6 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,ENSG00000189090,FAM25G,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.755769,-0.611844,-0.126752
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 35.8156% (minimum 97%, Missing); salivary gland: 54.0107% (minimum 97%, Missing); skeletal muscle: 98.0583% (minimum 99%, Missing); skin: 19.4231% (minimum 95%, Missing); small intestine: 86.3248% (minimum 99%, Missing)",0,80,unavailable,1.6,18.1,41.9,"skin: 41.9 nTPM (manageable, limit 5); esophagus: 18.1 nTPM (protected, limit 2); salivary gland: 8.6 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,ENSG00000189090,FAM25G,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.755769,-0.611844,-0.126752
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,12.2,7.4,12.8,"skin: 12.8 nTPM (manageable, limit 5); bone marrow: 12.2 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); liver: 7.6 nTPM (vital, limit 1); lymph node: 7.4 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); cerebral cortex: 7.4 nTPM (vital, limit 2); small intestine: 6.5 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 2); esophagus: 6.2 nTPM (protected, limit 2); basal ganglia: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); cerebellum: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); salivary gland: 5.5 nTPM (protected, limit 2); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 2); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000189114,BLOC1S3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.8519% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 53.4351% (minimum 99%, Baseline (adaptation disabled)); amygdala: 56.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 53.0303% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 36.4583% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.5556% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.6111% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 55.5556% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.3770% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.0303% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.2636% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 56.4516% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.5556% (minimum 99%, Baseline (adaptation disabled)); liver: 47.9452% (minimum 99%, Baseline (adaptation disabled)); lung: 56.9106% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.6111% (minimum 97%, Baseline (adaptation disabled)); midbrain: 56.9106% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.2636% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.3448% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.9469% (minimum 99%, Baseline (adaptation disabled)); rectum: 62.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 68.6275% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 35.3535% (minimum 95%, Baseline (adaptation disabled)); small intestine: 51.8519% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.2202% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.4351% (minimum 99%, Baseline (adaptation disabled)); spleen: 39.5480% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.6111% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.3448% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.8696% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.6275% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.2388% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,12.2,7.4,12.8,"skin: 12.8 nTPM (manageable, limit 5); bone marrow: 12.2 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); liver: 7.6 nTPM (vital, limit 1); lymph node: 7.4 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); cerebral cortex: 7.4 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.4 nTPM (protected, limit 2); basal ganglia: 6.2 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 2); adrenal gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 2); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000189114,BLOC1S3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.596465,-0.483889,-0.625417
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.8519% (minimum 90%, Approved); adrenal gland: 53.4351% (minimum 99%, Missing); amygdala: 56.0000% (minimum 99%, Missing); basal ganglia: 53.0303% (minimum 99%, Missing); bone marrow: 36.4583% (minimum 99%, Missing); cerebellum: 55.5556% (minimum 99%, Missing); cerebral cortex: 48.6111% (minimum 98%, Approved); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 55.5556% (minimum 97%, Missing); duodenum: 57.3770% (minimum 99%, Missing); esophagus: 53.0303% (minimum 97%, Missing); heart muscle: 58.3333% (minimum 98%, Approved); hippocampal formation: 54.2636% (minimum 99%, Missing); hypothalamus: 56.4516% (minimum 99%, Missing); kidney: 55.5556% (minimum 99%, Missing); liver: 47.9452% (minimum 99%, Missing); lung: 56.9106% (minimum 99%, Missing); lymph node: 48.6111% (minimum 97%, Missing); midbrain: 56.9106% (minimum 99%, Missing); pancreas: 54.2636% (minimum 99%, Missing); parathyroid gland: 60.3448% (minimum 97%, Missing); pituitary gland: 61.9469% (minimum 99%, Missing); rectum: 62.5000% (minimum 97%, Missing); retina: 68.6275% (minimum 99%, Missing); salivary gland: 56.0000% (minimum 97%, Missing); skeletal muscle: 62.5000% (minimum 98%, Approved); skin: 35.3535% (minimum 95%, Missing); small intestine: 51.8519% (minimum 99%, Missing); smooth muscle: 64.2202% (minimum 98%, Approved); spinal cord: 53.4351% (minimum 99%, Missing); spleen: 39.5480% (minimum 95%, Missing); stomach: 48.6111% (minimum 97%, Missing); thymus: 60.3448% (minimum 95%, Missing); thyroid gland: 60.8696% (minimum 95%, Missing); tongue: 68.6275% (minimum 97%, Missing); urinary bladder: 52.2388% (minimum 97%, Missing)",0,5,partial,12.2,7.4,12.8,"skin: 12.8 nTPM (manageable, limit 5); bone marrow: 12.2 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); liver: 7.6 nTPM (vital, limit 1); lymph node: 7.4 nTPM (protected, limit 2); stomach: 7.4 nTPM (protected, limit 2); cerebral cortex: 7.4 nTPM (vital, limit 2); small intestine: 6.5 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 2); esophagus: 6.2 nTPM (protected, limit 2); basal ganglia: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); cerebellum: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 2); salivary gland: 5.5 nTPM (protected, limit 2); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 2); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000189114,BLOC1S3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.596465,-0.483889,-0.625417
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189132,FAM47B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189132,FAM47B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189132,FAM47B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12.2,3.8,1.8,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189134,NKAPL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.5783% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.3190% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.6254% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.8129% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.5783% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.1751% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.4407% (minimum 99%, Baseline (adaptation disabled)); colon: 93.7313% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.5014% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.1751% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.8994% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.2943% (minimum 99%, Baseline (adaptation disabled)); liver: 97.5155% (minimum 99%, Baseline (adaptation disabled)); lung: 97.8193% (minimum 99%, Baseline (adaptation disabled)); midbrain: 89.7143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.4407% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.0120% (minimum 99%, Baseline (adaptation disabled)); retina: 72.0183% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.1515% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.3261% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.8193% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.7317% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.9518% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.6154% (minimum 97%, Baseline (adaptation disabled)); tongue: 89.2045% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.2943% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,12.2,3.8,1.8,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189134,NKAPL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00421687,-0.0779545,-0.269817
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.5783% (minimum 95%, Missing); adrenal gland: 96.3190% (minimum 99%, Missing); amygdala: 92.6254% (minimum 99%, Missing); basal ganglia: 91.8129% (minimum 99%, Missing); cerebellum: 94.5783% (minimum 99%, Missing); cerebral cortex: 93.1751% (minimum 99%, Missing); choroid plexus: 95.4407% (minimum 99%, Missing); colon: 93.7313% (minimum 97%, Missing); heart muscle: 86.5014% (minimum 99%, Missing); hippocampal formation: 93.1751% (minimum 99%, Missing); hypothalamus: 92.8994% (minimum 99%, Missing); kidney: 94.2943% (minimum 99%, Missing); liver: 97.5155% (minimum 99%, Missing); lung: 97.8193% (minimum 99%, Missing); midbrain: 89.7143% (minimum 99%, Missing); pancreas: 95.4407% (minimum 99%, Missing); pituitary gland: 94.0120% (minimum 99%, Missing); retina: 72.0183% (minimum 99%, Missing); salivary gland: 95.1515% (minimum 97%, Missing); skeletal muscle: 85.3261% (minimum 99%, Missing); small intestine: 97.8193% (minimum 99%, Missing); smooth muscle: 95.7317% (minimum 99%, Missing); spinal cord: 88.9518% (minimum 99%, Missing); stomach: 96.6154% (minimum 97%, Missing); tongue: 89.2045% (minimum 97%, Missing); urinary bladder: 94.2943% (minimum 97%, Missing)",0,80,unavailable,12.2,3.8,1.8,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 2); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189134,NKAPL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00421687,-0.0779545,-0.269817
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000189139,FSCB,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000189139,FSCB,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000189139,FSCB,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,2.5,1.9,2.4,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000189144,ZNF573,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.1163% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.7949% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.5745% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.8485% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.2927% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.8485% (minimum 99%, Baseline (adaptation disabled)); colon: 75.6757% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.2927% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.6757% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.3226% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 82.3529% (minimum 99%, Baseline (adaptation disabled)); lung: 68.2927% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.7949% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.7778% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.7949% (minimum 97%, Baseline (adaptation disabled)); retina: 52.8302% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.7778% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 75.6757% (minimum 99%, Baseline (adaptation disabled)); skin: 57.1429% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.6842% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 77.7778% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.3529% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.6364% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.5745% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.7949% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.8462% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.8485% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.0000% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,2.5,1.9,2.4,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000189144,ZNF573,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.411538,-0.374255,-0.461698
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 65.1163% (minimum 95%, Missing); adrenal gland: 71.7949% (minimum 99%, Missing); amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 59.5745% (minimum 99%, Missing); cerebellum: 84.8485% (minimum 99%, Missing); cerebral cortex: 68.2927% (minimum 99%, Missing); choroid plexus: 84.8485% (minimum 99%, Missing); colon: 75.6757% (minimum 97%, Missing); duodenum: 68.2927% (minimum 99%, Missing); esophagus: 80.0000% (minimum 97%, Missing); heart muscle: 75.6757% (minimum 99%, Missing); hippocampal formation: 90.3226% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); kidney: 70.0000% (minimum 99%, Missing); liver: 82.3529% (minimum 99%, Missing); lung: 68.2927% (minimum 99%, Missing); lymph node: 71.7949% (minimum 97%, Missing); midbrain: 87.5000% (minimum 99%, Missing); pancreas: 70.0000% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 77.7778% (minimum 99%, Missing); rectum: 71.7949% (minimum 97%, Missing); retina: 52.8302% (minimum 99%, Missing); salivary gland: 77.7778% (minimum 97%, Missing); skeletal muscle: 75.6757% (minimum 99%, Missing); skin: 57.1429% (minimum 95%, Missing); small intestine: 73.6842% (minimum 99%, Missing); smooth muscle: 77.7778% (minimum 99%, Missing); spinal cord: 82.3529% (minimum 99%, Missing); spleen: 63.6364% (minimum 95%, Missing); stomach: 59.5745% (minimum 97%, Missing); thymus: 71.7949% (minimum 95%, Missing); thyroid gland: 53.8462% (minimum 95%, Missing); tongue: 84.8485% (minimum 97%, Missing); urinary bladder: 80.0000% (minimum 97%, Missing)",0,3,partial,2.5,1.9,2.4,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000189144,ZNF573,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.411538,-0.374255,-0.461698
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.1,2.9,2.4,"retina: 3.1 nTPM (vital, limit 1); tongue: 2.9 nTPM (protected, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); urinary bladder: 2.3 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189164,ZNF527,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.5385% (minimum 99%, Baseline (adaptation disabled)); amygdala: 69.5652% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 58.1818% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.5385% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.3061% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.1905% (minimum 99%, Baseline (adaptation disabled)); colon: 56.1404% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.0513% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.5652% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.2593% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.0851% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.3061% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.3774% (minimum 99%, Baseline (adaptation disabled)); liver: 65.3061% (minimum 99%, Baseline (adaptation disabled)); lung: 69.5652% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.5385% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.0851% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.1724% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.2593% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.5652% (minimum 97%, Baseline (adaptation disabled)); retina: 50.7937% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 59.2593% (minimum 99%, Baseline (adaptation disabled)); skin: 65.3061% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.3061% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.0851% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.7451% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.3061% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.1429% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 95%, Baseline (adaptation disabled)); tongue: 52.4590% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.1818% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.1,2.9,2.4,"retina: 3.1 nTPM (vital, limit 1); tongue: 2.9 nTPM (protected, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); urinary bladder: 2.3 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189164,ZNF527,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.378571,-0.44541,-0.482063
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 95%, Missing); adrenal gland: 61.5385% (minimum 99%, Missing); amygdala: 69.5652% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 58.1818% (minimum 99%, Missing); cerebellum: 61.5385% (minimum 99%, Missing); cerebral cortex: 65.3061% (minimum 99%, Missing); choroid plexus: 76.1905% (minimum 99%, Missing); colon: 56.1404% (minimum 97%, Missing); duodenum: 82.0513% (minimum 99%, Missing); esophagus: 69.5652% (minimum 97%, Missing); heart muscle: 59.2593% (minimum 99%, Missing); hippocampal formation: 68.0851% (minimum 99%, Missing); hypothalamus: 65.3061% (minimum 99%, Missing); kidney: 60.3774% (minimum 99%, Missing); liver: 65.3061% (minimum 99%, Missing); lung: 69.5652% (minimum 99%, Missing); lymph node: 61.5385% (minimum 97%, Missing); midbrain: 68.0851% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 55.1724% (minimum 97%, Missing); pituitary gland: 59.2593% (minimum 99%, Missing); rectum: 69.5652% (minimum 97%, Missing); retina: 50.7937% (minimum 99%, Missing); salivary gland: 64.0000% (minimum 97%, Missing); skeletal muscle: 59.2593% (minimum 99%, Missing); skin: 65.3061% (minimum 95%, Missing); small intestine: 65.3061% (minimum 99%, Missing); smooth muscle: 64.0000% (minimum 99%, Missing); spinal cord: 68.0851% (minimum 99%, Missing); spleen: 62.7451% (minimum 95%, Missing); stomach: 65.3061% (minimum 97%, Missing); thymus: 57.1429% (minimum 95%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); tongue: 52.4590% (minimum 97%, Missing); urinary bladder: 58.1818% (minimum 97%, Missing)",0,80,unavailable,3.1,2.9,2.4,"retina: 3.1 nTPM (vital, limit 1); tongue: 2.9 nTPM (protected, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); urinary bladder: 2.3 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189164,ZNF527,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.378571,-0.44541,-0.482063
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000189167,ZAR1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 87.5000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.5000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000189167,ZAR1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.095,-0.115
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 87.5000% (minimum 99%, Missing); lymph node: 87.5000% (minimum 97%, Missing)",0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000189167,ZAR1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,-0.095,-0.115
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,9.5,"skin: 9.5 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000189169,KRTAP10-12,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,9.5,"skin: 9.5 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000189169,KRTAP10-12,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,9.5,"skin: 9.5 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000189169,KRTAP10-12,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189186,DCAF8L2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189186,DCAF8L2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189186,DCAF8L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000189252,SPANXN3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.3471% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9605% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000189252,SPANXN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00652893
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.3471% (minimum 99%, Missing); small intestine: 98.9605% (minimum 99%, Missing)",0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000189252,SPANXN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00652893
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.8,8.9,3.2,"parathyroid gland: 8.9 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189269,DRICH1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9892% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.4180% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.5739% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6871% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.3675% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.8308% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.7479% (minimum 99%, Baseline (adaptation disabled)); liver: 98.4716% (minimum 99%, Baseline (adaptation disabled)); lung: 97.4082% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.1477% (minimum 97%, Baseline (adaptation disabled)); pancreas: 95.1477% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.5185% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.9892% (minimum 99%, Baseline (adaptation disabled)); retina: 92.2290% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.7811% (minimum 97%, Baseline (adaptation disabled)); skin: 93.3747% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.8308% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.9892% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.8,8.9,3.2,"parathyroid gland: 8.9 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189269,DRICH1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0162526,-0.134815,-0.0677096
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9892% (minimum 99%, Missing); bone marrow: 92.4180% (minimum 99%, Missing); cerebellum: 96.5739% (minimum 99%, Missing); cerebral cortex: 98.6871% (minimum 99%, Missing); choroid plexus: 96.3675% (minimum 99%, Missing); duodenum: 97.8308% (minimum 99%, Missing); kidney: 94.7479% (minimum 99%, Missing); liver: 98.4716% (minimum 99%, Missing); lung: 97.4082% (minimum 99%, Missing); lymph node: 95.1477% (minimum 97%, Missing); pancreas: 95.1477% (minimum 99%, Missing); parathyroid gland: 83.5185% (minimum 97%, Missing); pituitary gland: 96.9892% (minimum 99%, Missing); retina: 92.2290% (minimum 99%, Missing); salivary gland: 96.7811% (minimum 97%, Missing); skin: 93.3747% (minimum 95%, Missing); small intestine: 97.8308% (minimum 99%, Missing); smooth muscle: 96.9892% (minimum 99%, Missing)",0,80,unavailable,3.8,8.9,3.2,"parathyroid gland: 8.9 nTPM (protected, limit 2); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189269,DRICH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0162526,-0.134815,-0.0677096
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,4.5,4.6,4.2,"parathyroid gland: 4.6 nTPM (protected, limit 2); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); retina: 3.7 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); liver: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000189298,ZKSCAN3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.8333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.1053% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.9524% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.6875% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.2581% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.2727% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.8630% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 60.7143% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.8333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.9189% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.9189% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.6875% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.6875% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.4458% (minimum 99%, Baseline (adaptation disabled)); liver: 65.3846% (minimum 99%, Baseline (adaptation disabled)); lung: 62.9630% (minimum 99%, Baseline (adaptation disabled)); lymph node: 63.7500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.4615% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.8630% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.5773% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.2338% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.9545% (minimum 97%, Baseline (adaptation disabled)); retina: 57.9545% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.9189% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 57.9545% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.9189% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.1250% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.1194% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.7143% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.0440% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.8387% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.8387% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.3846% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,4.5,4.6,4.2,"parathyroid gland: 4.6 nTPM (protected, limit 2); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); retina: 3.7 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); liver: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000189298,ZKSCAN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.401613,-0.444227,-0.45875
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.8333% (minimum 90%, Approved); adrenal gland: 67.1053% (minimum 99%, Missing); amygdala: 80.9524% (minimum 99%, Missing); basal ganglia: 79.6875% (minimum 99%, Missing); bone marrow: 82.2581% (minimum 99%, Missing); cerebellum: 77.2727% (minimum 99%, Missing); cerebral cortex: 69.8630% (minimum 99%, Missing); choroid plexus: 68.0000% (minimum 99%, Missing); colon: 60.7143% (minimum 97%, Missing); duodenum: 70.8333% (minimum 99%, Missing); esophagus: 68.9189% (minimum 97%, Missing); heart muscle: 68.9189% (minimum 99%, Missing); hippocampal formation: 79.6875% (minimum 99%, Missing); hypothalamus: 79.6875% (minimum 99%, Missing); kidney: 61.4458% (minimum 99%, Missing); liver: 65.3846% (minimum 99%, Missing); lung: 62.9630% (minimum 99%, Missing); lymph node: 63.7500% (minimum 97%, Missing); midbrain: 78.4615% (minimum 99%, Missing); pancreas: 69.8630% (minimum 99%, Missing); parathyroid gland: 52.5773% (minimum 97%, Missing); pituitary gland: 66.2338% (minimum 99%, Missing); rectum: 57.9545% (minimum 97%, Missing); retina: 57.9545% (minimum 99%, Missing); salivary gland: 68.9189% (minimum 95%, Approved); skeletal muscle: 68.0000% (minimum 99%, Missing); skin: 57.9545% (minimum 95%, Missing); small intestine: 68.9189% (minimum 99%, Missing); smooth muscle: 53.1250% (minimum 99%, Missing); spinal cord: 76.1194% (minimum 99%, Missing); spleen: 60.7143% (minimum 95%, Missing); stomach: 56.0440% (minimum 97%, Missing); thymus: 54.8387% (minimum 95%, Missing); thyroid gland: 54.8387% (minimum 95%, Missing); tongue: 68.0000% (minimum 97%, Missing); urinary bladder: 65.3846% (minimum 97%, Missing)",0,3,partial,4.5,4.6,4.2,"parathyroid gland: 4.6 nTPM (protected, limit 2); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); retina: 3.7 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); liver: 2.7 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); skeletal muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000189298,ZKSCAN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.401613,-0.444227,-0.45875
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189299,FOXR2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189299,FOXR2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189299,FOXR2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189326,SPANXN4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189326,SPANXN4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189326,SPANXN4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189357,SPATA31D4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189357,SPATA31D4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000189357,SPATA31D4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.3,3.6,4.5,"lymph node: 3.6 nTPM (protected, limit 2); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189362,NEMP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.4419% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.4444% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.3158% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.3158% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.4167% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.7692% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.7317% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.3784% (minimum 99%, Baseline (adaptation disabled)); colon: 69.0476% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.3158% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.9091% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 76.3158% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.5000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.3158% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.0476% (minimum 99%, Baseline (adaptation disabled)); liver: 63.0435% (minimum 99%, Baseline (adaptation disabled)); lung: 64.4444% (minimum 99%, Baseline (adaptation disabled)); lymph node: 44.6154% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.7317% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.5000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 74.3590% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.7317% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.3158% (minimum 97%, Baseline (adaptation disabled)); retina: 70.7317% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.1837% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 85.2941% (minimum 99%, Baseline (adaptation disabled)); skin: 59.1837% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.4444% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 72.5000% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.7692% (minimum 95%, Baseline (adaptation disabled)); stomach: 61.7021% (minimum 97%, Baseline (adaptation disabled)); thymus: 39.1892% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.4167% (minimum 95%, Baseline (adaptation disabled)); tongue: 82.8571% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 70.7317% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.3,3.6,4.5,"lymph node: 3.6 nTPM (protected, limit 2); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189362,NEMP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.558108,-0.523846,-0.432308
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.4419% (minimum 95%, Missing); adrenal gland: 64.4444% (minimum 99%, Missing); amygdala: 76.3158% (minimum 99%, Missing); basal ganglia: 76.3158% (minimum 99%, Missing); bone marrow: 60.4167% (minimum 99%, Missing); cerebellum: 55.7692% (minimum 99%, Missing); cerebral cortex: 70.7317% (minimum 99%, Missing); choroid plexus: 78.3784% (minimum 99%, Missing); colon: 69.0476% (minimum 97%, Missing); duodenum: 76.3158% (minimum 99%, Missing); esophagus: 65.9091% (minimum 97%, Missing); heart muscle: 76.3158% (minimum 99%, Missing); hippocampal formation: 72.5000% (minimum 99%, Missing); hypothalamus: 76.3158% (minimum 99%, Missing); kidney: 69.0476% (minimum 99%, Missing); liver: 63.0435% (minimum 99%, Missing); lung: 64.4444% (minimum 99%, Missing); lymph node: 44.6154% (minimum 97%, Missing); midbrain: 70.7317% (minimum 99%, Missing); pancreas: 72.5000% (minimum 99%, Missing); parathyroid gland: 74.3590% (minimum 97%, Missing); pituitary gland: 70.7317% (minimum 99%, Missing); rectum: 76.3158% (minimum 97%, Missing); retina: 70.7317% (minimum 99%, Missing); salivary gland: 59.1837% (minimum 97%, Missing); skeletal muscle: 85.2941% (minimum 99%, Missing); skin: 59.1837% (minimum 95%, Missing); small intestine: 64.4444% (minimum 99%, Missing); smooth muscle: 72.5000% (minimum 99%, Missing); spinal cord: 72.5000% (minimum 99%, Missing); spleen: 55.7692% (minimum 95%, Missing); stomach: 61.7021% (minimum 97%, Missing); thymus: 39.1892% (minimum 95%, Missing); thyroid gland: 60.4167% (minimum 95%, Missing); tongue: 82.8571% (minimum 97%, Missing); urinary bladder: 70.7317% (minimum 97%, Missing)",0,80,unavailable,2.3,3.6,4.5,"lymph node: 3.6 nTPM (protected, limit 2); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000189362,NEMP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.558108,-0.523846,-0.432308
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen; tonsil,ENSG00000189375,TBC1D28,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen; tonsil,ENSG00000189375,TBC1D28,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0407834,0.0253704,0.00078341
True,compatible,,True,True,True,,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen; tonsil,ENSG00000189375,TBC1D28,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0407834,0.0253704,0.00078341
True,compatible,,True,True,False,,0,6,partial,0.7,0.1,0.3,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000189401,OTUD6A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 86.7925% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.8333% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.8723% (minimum 99%, Baseline (adaptation disabled)); retina: 97.8723% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.8723% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 93.8776% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,0.7,0.1,0.3,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000189401,OTUD6A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,-0.0112245,0.0087234,-0.122075
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 86.7925% (minimum 95%, Enhanced); choroid plexus: 95.8333% (minimum 99%, Missing); retina: 97.8723% (minimum 99%, Missing)",0,6,partial,0.7,0.1,0.3,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000189401,OTUD6A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.05,0.03,-0.0820755
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.4,5.9,3.1,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 2); salivary gland: 4.3 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196074,SYCP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.0958% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.1221% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.3134% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.7846% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.9326% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.7220% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8180% (minimum 99%, Baseline (adaptation disabled)); colon: 96.9838% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.3134% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.5701% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.3134% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.3134% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.8696% (minimum 99%, Baseline (adaptation disabled)); liver: 97.4359% (minimum 99%, Baseline (adaptation disabled)); lung: 95.2164% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.3567% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.6522% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.7220% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.6522% (minimum 99%, Baseline (adaptation disabled)); retina: 96.7593% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.6725% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.2093% (minimum 99%, Baseline (adaptation disabled)); skin: 93.9326% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.7846% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.3529% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.7593% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.3036% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.6310% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 94.7846% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.0920% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.4,5.9,3.1,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 2); salivary gland: 4.3 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196074,SYCP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0190423,-0.0936897,-0.12278
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.0958% (minimum 95%, Missing); adrenal gland: 98.1221% (minimum 99%, Missing); amygdala: 96.3134% (minimum 99%, Missing); basal ganglia: 95.0000% (minimum 99%, Missing); bone marrow: 94.7846% (minimum 99%, Missing); cerebellum: 93.9326% (minimum 99%, Missing); cerebral cortex: 93.7220% (minimum 99%, Missing); choroid plexus: 98.8180% (minimum 99%, Missing); colon: 96.9838% (minimum 97%, Missing); duodenum: 96.3134% (minimum 99%, Missing); heart muscle: 94.5701% (minimum 99%, Missing); hippocampal formation: 96.3134% (minimum 99%, Missing); hypothalamus: 96.3134% (minimum 99%, Missing); kidney: 90.8696% (minimum 99%, Missing); liver: 97.4359% (minimum 99%, Missing); lung: 95.2164% (minimum 99%, Missing); lymph node: 94.3567% (minimum 97%, Missing); midbrain: 95.6522% (minimum 99%, Missing); pancreas: 86.7220% (minimum 99%, Missing); pituitary gland: 95.6522% (minimum 99%, Missing); retina: 96.7593% (minimum 99%, Missing); salivary gland: 90.6725% (minimum 97%, Missing); skeletal muscle: 97.2093% (minimum 99%, Missing); skin: 93.9326% (minimum 95%, Missing); small intestine: 94.7846% (minimum 99%, Missing); smooth muscle: 98.3529% (minimum 99%, Missing); spinal cord: 96.7593% (minimum 99%, Missing); spleen: 93.3036% (minimum 95%, Missing); stomach: 87.6310% (minimum 97%, Missing); thyroid gland: 94.7846% (minimum 95%, Missing); urinary bladder: 96.0920% (minimum 97%, Missing)",0,80,unavailable,6.4,5.9,3.1,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 2); salivary gland: 4.3 nTPM (protected, limit 2); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196074,SYCP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0190423,-0.0936897,-0.12278
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,3.6,3.2,"parathyroid gland: 3.6 nTPM (protected, limit 2); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000196109,ZNF676,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 78.7234% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.8718% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.3684% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.8718% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.0833% (minimum 99%, Baseline (adaptation disabled)); colon: 80.4348% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.3684% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.8718% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.8718% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.8718% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.1538% (minimum 99%, Baseline (adaptation disabled)); liver: 97.3684% (minimum 99%, Baseline (adaptation disabled)); lung: 94.8718% (minimum 99%, Baseline (adaptation disabled)); midbrain: 90.2439% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.7234% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.6849% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.0833% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 92.5000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.5000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.3684% (minimum 99%, Baseline (adaptation disabled)); skin: 92.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.7234% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.0952% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.0465% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.8718% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 53.6232% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.5000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 90.2439% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.5,3.6,3.2,"parathyroid gland: 3.6 nTPM (protected, limit 2); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000196109,ZNF676,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.413768,-0.463151,-0.278462
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 78.7234% (minimum 95%, Missing); adrenal gland: 94.8718% (minimum 99%, Missing); amygdala: 97.3684% (minimum 99%, Missing); basal ganglia: 94.8718% (minimum 99%, Missing); cerebral cortex: 77.0833% (minimum 99%, Missing); colon: 80.4348% (minimum 97%, Missing); duodenum: 97.3684% (minimum 99%, Missing); esophagus: 94.8718% (minimum 97%, Missing); heart muscle: 74.0000% (minimum 99%, Missing); hippocampal formation: 94.8718% (minimum 99%, Missing); hypothalamus: 94.8718% (minimum 99%, Missing); kidney: 71.1538% (minimum 99%, Missing); liver: 97.3684% (minimum 99%, Missing); lung: 94.8718% (minimum 99%, Missing); midbrain: 90.2439% (minimum 99%, Missing); pancreas: 78.7234% (minimum 99%, Missing); parathyroid gland: 50.6849% (minimum 97%, Missing); pituitary gland: 77.0833% (minimum 99%, Missing); rectum: 92.5000% (minimum 97%, Missing); retina: 92.5000% (minimum 99%, Missing); salivary gland: 92.5000% (minimum 97%, Missing); skeletal muscle: 97.3684% (minimum 99%, Missing); skin: 92.5000% (minimum 95%, Missing); small intestine: 92.5000% (minimum 99%, Missing); smooth muscle: 78.7234% (minimum 99%, Missing); spinal cord: 88.0952% (minimum 99%, Missing); spleen: 86.0465% (minimum 95%, Missing); stomach: 94.8718% (minimum 97%, Missing); thyroid gland: 53.6232% (minimum 95%, Missing); tongue: 92.5000% (minimum 97%, Missing); urinary bladder: 90.2439% (minimum 97%, Missing)",0,80,unavailable,1.5,3.6,3.2,"parathyroid gland: 3.6 nTPM (protected, limit 2); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000196109,ZNF676,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.413768,-0.463151,-0.278462
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.9,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000196119,OR8A1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 25.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 27.2727% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 97%, Baseline (adaptation disabled)); pancreas: 60.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); rectum: 75.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 37.5000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 33.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.0000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 75.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.9,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000196119,OR8A1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.616667,-0.37,-0.74
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 75.0000% (minimum 95%, Missing); bone marrow: 25.0000% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); liver: 27.2727% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); pancreas: 60.0000% (minimum 99%, Missing); parathyroid gland: 60.0000% (minimum 97%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 37.5000% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 97%, Missing); skin: 33.3333% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spleen: 60.0000% (minimum 95%, Missing); stomach: 75.0000% (minimum 97%, Missing); thyroid gland: 75.0000% (minimum 95%, Missing)",0,80,unavailable,0.9,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000196119,OR8A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.616667,-0.37,-0.74
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.3,2.7,3.8,"lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196172,ZNF681,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.4194% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.5455% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.0638% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.7273% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.8140% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.4194% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.5882% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.4194% (minimum 99%, Baseline (adaptation disabled)); liver: 92.3077% (minimum 99%, Baseline (adaptation disabled)); lung: 72.7273% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.0588% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.4194% (minimum 99%, Baseline (adaptation disabled)); pancreas: 57.1429% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); rectum: 57.1429% (minimum 97%, Baseline (adaptation disabled)); retina: 72.7273% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.7586% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 53.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.1429% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.5882% (minimum 97%, Baseline (adaptation disabled)); thymus: 38.7097% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.3077% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.5385% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.3,2.7,3.8,"lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196172,ZNF681,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.562903,-0.499412,-0.479362
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 80.0000% (minimum 99%, Missing); bone marrow: 77.4194% (minimum 99%, Missing); cerebellum: 54.5455% (minimum 99%, Missing); cerebral cortex: 51.0638% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 72.7273% (minimum 99%, Missing); esophagus: 55.8140% (minimum 97%, Missing); heart muscle: 85.7143% (minimum 99%, Missing); hippocampal formation: 77.4194% (minimum 99%, Missing); hypothalamus: 70.5882% (minimum 99%, Missing); kidney: 77.4194% (minimum 99%, Missing); liver: 92.3077% (minimum 99%, Missing); lung: 72.7273% (minimum 99%, Missing); lymph node: 47.0588% (minimum 97%, Missing); midbrain: 77.4194% (minimum 99%, Missing); pancreas: 57.1429% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 57.1429% (minimum 97%, Missing); retina: 72.7273% (minimum 99%, Missing); salivary gland: 82.7586% (minimum 97%, Missing); skeletal muscle: 96.0000% (minimum 99%, Missing); skin: 53.3333% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 75.0000% (minimum 99%, Missing); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 57.1429% (minimum 95%, Missing); stomach: 70.5882% (minimum 97%, Missing); thymus: 38.7097% (minimum 95%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); tongue: 92.3077% (minimum 97%, Missing); urinary bladder: 61.5385% (minimum 97%, Missing)",0,80,unavailable,2.3,2.7,3.8,"lymph node: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196172,ZNF681,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.562903,-0.499412,-0.479362
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196184,OR10J1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196184,OR10J1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196184,OR10J1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,25.2,8.4,5.8,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 2); rectum: 8.3 nTPM (protected, limit 2); stomach: 8.1 nTPM (protected, limit 2); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 2); urinary bladder: 6.5 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); thymus: 5.8 nTPM (manageable, limit 5); liver: 5.7 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 5.4 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 2); lung: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196233,LCOR,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.5506% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.8554% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.6341% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.6341% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 17.3770% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 45.2991% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.8889% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.7143% (minimum 99%, Baseline (adaptation disabled)); colon: 38.6861% (minimum 97%, Baseline (adaptation disabled)); duodenum: 32.7160% (minimum 99%, Baseline (adaptation disabled)); esophagus: 43.8017% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.5506% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 60.9195% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.3529% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.9615% (minimum 99%, Baseline (adaptation disabled)); liver: 48.1818% (minimum 99%, Baseline (adaptation disabled)); lung: 53.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.4912% (minimum 97%, Baseline (adaptation disabled)); midbrain: 60.9195% (minimum 99%, Baseline (adaptation disabled)); pancreas: 40.1515% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.7895% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 50.9615% (minimum 99%, Baseline (adaptation disabled)); rectum: 38.9706% (minimum 97%, Baseline (adaptation disabled)); retina: 25.7282% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 49.5327% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 37.3239% (minimum 99%, Baseline (adaptation disabled)); skin: 56.9892% (minimum 95%, Baseline (adaptation disabled)); small intestine: 33.7580% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.3529% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 51.4563% (minimum 99%, Baseline (adaptation disabled)); spleen: 49.5327% (minimum 95%, Baseline (adaptation disabled)); stomach: 39.5522% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.7477% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 51.9608% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 44.9153% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,25.2,8.4,5.8,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 2); rectum: 8.3 nTPM (protected, limit 2); stomach: 8.1 nTPM (protected, limit 2); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 2); urinary bladder: 6.5 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); thymus: 5.8 nTPM (manageable, limit 5); liver: 5.7 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 5.4 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 2); lung: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196233,LCOR,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.472523,-0.583139,-0.81623
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.5506% (minimum 95%, Missing); adrenal gland: 63.8554% (minimum 99%, Missing); amygdala: 64.6341% (minimum 99%, Missing); basal ganglia: 64.6341% (minimum 99%, Missing); bone marrow: 17.3770% (minimum 99%, Missing); cerebellum: 45.2991% (minimum 99%, Missing); cerebral cortex: 58.8889% (minimum 99%, Missing); choroid plexus: 75.7143% (minimum 99%, Missing); colon: 38.6861% (minimum 97%, Missing); duodenum: 32.7160% (minimum 99%, Missing); esophagus: 43.8017% (minimum 97%, Missing); heart muscle: 59.5506% (minimum 99%, Missing); hippocampal formation: 60.9195% (minimum 99%, Missing); hypothalamus: 62.3529% (minimum 99%, Missing); kidney: 50.9615% (minimum 99%, Missing); liver: 48.1818% (minimum 99%, Missing); lung: 53.0000% (minimum 99%, Missing); lymph node: 46.4912% (minimum 97%, Missing); midbrain: 60.9195% (minimum 99%, Missing); pancreas: 40.1515% (minimum 99%, Missing); parathyroid gland: 55.7895% (minimum 97%, Missing); pituitary gland: 50.9615% (minimum 99%, Missing); rectum: 38.9706% (minimum 97%, Missing); retina: 25.7282% (minimum 99%, Missing); salivary gland: 49.5327% (minimum 97%, Missing); skeletal muscle: 37.3239% (minimum 99%, Missing); skin: 56.9892% (minimum 95%, Missing); small intestine: 33.7580% (minimum 99%, Missing); smooth muscle: 62.3529% (minimum 99%, Missing); spinal cord: 51.4563% (minimum 99%, Missing); spleen: 49.5327% (minimum 95%, Missing); stomach: 39.5522% (minimum 97%, Missing); thymus: 47.7477% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 51.9608% (minimum 97%, Missing); urinary bladder: 44.9153% (minimum 97%, Missing)",0,2,partial,25.2,8.4,5.8,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 2); rectum: 8.3 nTPM (protected, limit 2); stomach: 8.1 nTPM (protected, limit 2); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 2); urinary bladder: 6.5 nTPM (protected, limit 2); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 2); thymus: 5.8 nTPM (manageable, limit 5); liver: 5.7 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 5.4 nTPM (protected, limit 2); thyroid gland: 5.3 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 2); lung: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 2); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196233,LCOR,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.472523,-0.583139,-0.81623
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000196242,OR2C3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 63.6364% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); thymus: 87.5000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000196242,OR2C3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,-0.075,0.03,-0.353636
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 87.5000% (minimum 99%, Missing); pancreas: 87.5000% (minimum 99%, Missing); retina: 63.6364% (minimum 99%, Missing); skeletal muscle: 87.5000% (minimum 99%, Missing); smooth muscle: 87.5000% (minimum 99%, Missing); thymus: 87.5000% (minimum 95%, Missing)",0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000196242,OR2C3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,-0.075,0.03,-0.353636
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,1.3,0.4,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000196335,STK31,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.2622% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.9528% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,1.3,0.4,0.2,"cerebellum: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000196335,STK31,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0467949,0.0236102,-0.0104724
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 98.2622% (minimum 99%, Missing)",0,4,partial,1.3,0.4,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,ENSG00000196335,STK31,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Loriot 2025;da Silva 2017,0.0467949,0.0236102,-0.00737757
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000196341,OR8D1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 85.7143% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.7143% (minimum 99%, Baseline (adaptation disabled)); retina: 85.7143% (minimum 99%, Baseline (adaptation disabled)); skin: 85.7143% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000196341,OR8D1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,-0.0928571,0.03,-0.132857
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 85.7143% (minimum 99%, Missing); choroid plexus: 85.7143% (minimum 99%, Missing); retina: 85.7143% (minimum 99%, Missing); skin: 85.7143% (minimum 95%, Missing)",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000196341,OR8D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,-0.0928571,0.03,-0.132857
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196350,ZNF729,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196350,ZNF729,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196350,ZNF729,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.2,4.4,3,"tongue: 4.4 nTPM (protected, limit 2); spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); bone marrow: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); lymph node: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196357,ZNF565,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.2128% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.5275% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.0412% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 67.3469% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.7059% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.9677% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.3465% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.0777% (minimum 99%, Baseline (adaptation disabled)); colon: 73.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 76.7442% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.1573% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.1573% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.3469% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.0412% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 69.4737% (minimum 99%, Baseline (adaptation disabled)); lung: 75.8621% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.3333% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.2128% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.7391% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.7391% (minimum 97%, Baseline (adaptation disabled)); retina: 66.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.7059% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.2642% (minimum 99%, Baseline (adaptation disabled)); skin: 68.7500% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.6471% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.2128% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.1111% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.4737% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.8621% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.7500% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.7391% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.2,4.4,3,"tongue: 4.4 nTPM (protected, limit 2); spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); bone marrow: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); lymph node: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196357,ZNF565,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.2625,-0.37,-0.378889
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.2128% (minimum 95%, Missing); adrenal gland: 72.5275% (minimum 99%, Missing); amygdala: 68.0412% (minimum 99%, Missing); basal ganglia: 67.3469% (minimum 99%, Missing); bone marrow: 64.7059% (minimum 99%, Missing); cerebellum: 70.9677% (minimum 99%, Missing); cerebral cortex: 65.3465% (minimum 99%, Missing); choroid plexus: 64.0777% (minimum 99%, Missing); colon: 73.3333% (minimum 97%, Missing); duodenum: 76.7442% (minimum 99%, Missing); esophagus: 74.1573% (minimum 97%, Missing); heart muscle: 74.1573% (minimum 99%, Missing); hippocampal formation: 67.3469% (minimum 99%, Missing); hypothalamus: 68.0412% (minimum 99%, Missing); kidney: 73.3333% (minimum 99%, Missing); liver: 69.4737% (minimum 99%, Missing); lung: 75.8621% (minimum 99%, Missing); lymph node: 75.0000% (minimum 97%, Missing); midbrain: 66.0000% (minimum 99%, Missing); pancreas: 73.3333% (minimum 99%, Missing); parathyroid gland: 70.2128% (minimum 97%, Missing); pituitary gland: 71.7391% (minimum 99%, Missing); rectum: 71.7391% (minimum 97%, Missing); retina: 66.0000% (minimum 99%, Missing); salivary gland: 64.7059% (minimum 97%, Missing); skeletal muscle: 62.2642% (minimum 99%, Missing); skin: 68.7500% (minimum 95%, Missing); small intestine: 77.6471% (minimum 99%, Missing); smooth muscle: 70.2128% (minimum 99%, Missing); spinal cord: 61.1111% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 69.4737% (minimum 97%, Missing); thymus: 75.8621% (minimum 95%, Missing); thyroid gland: 68.7500% (minimum 95%, Missing); tongue: 60.0000% (minimum 97%, Missing); urinary bladder: 71.7391% (minimum 97%, Missing)",0,80,unavailable,4.2,4.4,3,"tongue: 4.4 nTPM (protected, limit 2); spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); bone marrow: 3.6 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); rectum: 2.6 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); heart muscle: 2.3 nTPM (vital, limit 1); esophagus: 2.3 nTPM (protected, limit 2); lymph node: 2.2 nTPM (protected, limit 2); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196357,ZNF565,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.2625,-0.37,-0.378889
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.4,8.3,7.7,"duodenum: 10.4 nTPM (vital, limit 1); skeletal muscle: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 2); thyroid gland: 7.7 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.1 nTPM (manageable, limit 5); cerebral cortex: 6.9 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); esophagus: 4.9 nTPM (protected, limit 2); stomach: 4.8 nTPM (protected, limit 2); tongue: 4.6 nTPM (protected, limit 2); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196388,INCA1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.3089% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.8000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.1176% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.9271% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.6939% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.0544% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.3602% (minimum 99%, Baseline (adaptation disabled)); colon: 93.5484% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.6901% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.4483% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.2129% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.0635% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.6939% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.2465% (minimum 99%, Baseline (adaptation disabled)); liver: 92.6148% (minimum 99%, Baseline (adaptation disabled)); lung: 91.3386% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.8263% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.3602% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.4303% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.8685% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.4733% (minimum 99%, Baseline (adaptation disabled)); retina: 91.5187% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.4027% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.6901% (minimum 99%, Baseline (adaptation disabled)); skin: 85.9259% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.9259% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.6701% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.6148% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.7290% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.6250% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 85.7671% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.9804% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.6939% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.4,8.3,7.7,"duodenum: 10.4 nTPM (vital, limit 1); skeletal muscle: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 2); thyroid gland: 7.7 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.1 nTPM (manageable, limit 5); cerebral cortex: 6.9 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); esophagus: 4.9 nTPM (protected, limit 2); stomach: 4.8 nTPM (protected, limit 2); tongue: 4.6 nTPM (protected, limit 2); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196388,INCA1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.092329,-0.121737,-0.173099
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.3089% (minimum 95%, Missing); adrenal gland: 92.8000% (minimum 99%, Missing); amygdala: 94.1176% (minimum 99%, Missing); basal ganglia: 93.9271% (minimum 99%, Missing); bone marrow: 96.6667% (minimum 99%, Missing); cerebellum: 94.6939% (minimum 99%, Missing); cerebral cortex: 87.0544% (minimum 99%, Missing); choroid plexus: 93.3602% (minimum 99%, Missing); colon: 93.5484% (minimum 97%, Missing); duodenum: 81.6901% (minimum 99%, Missing); esophagus: 90.4483% (minimum 97%, Missing); heart muscle: 88.2129% (minimum 99%, Missing); hippocampal formation: 92.0635% (minimum 99%, Missing); hypothalamus: 94.6939% (minimum 99%, Missing); kidney: 92.2465% (minimum 99%, Missing); liver: 92.6148% (minimum 99%, Missing); lung: 91.3386% (minimum 99%, Missing); lymph node: 84.8263% (minimum 97%, Missing); midbrain: 93.3602% (minimum 99%, Missing); pancreas: 92.4303% (minimum 99%, Missing); parathyroid gland: 96.8685% (minimum 97%, Missing); pituitary gland: 95.4733% (minimum 99%, Missing); retina: 91.5187% (minimum 99%, Missing); salivary gland: 89.4027% (minimum 97%, Missing); skeletal muscle: 81.6901% (minimum 99%, Missing); skin: 85.9259% (minimum 95%, Missing); small intestine: 85.9259% (minimum 99%, Missing); smooth muscle: 95.6701% (minimum 99%, Missing); spinal cord: 92.6148% (minimum 99%, Missing); spleen: 86.7290% (minimum 95%, Missing); stomach: 90.6250% (minimum 97%, Missing); thyroid gland: 85.7671% (minimum 95%, Missing); tongue: 90.9804% (minimum 97%, Missing); urinary bladder: 94.6939% (minimum 97%, Missing)",0,80,unavailable,10.4,8.3,7.7,"duodenum: 10.4 nTPM (vital, limit 1); skeletal muscle: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 2); thyroid gland: 7.7 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.1 nTPM (manageable, limit 5); cerebral cortex: 6.9 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); esophagus: 4.9 nTPM (protected, limit 2); stomach: 4.8 nTPM (protected, limit 2); tongue: 4.6 nTPM (protected, limit 2); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196388,INCA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.092329,-0.121737,-0.173099
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.9,6.9,3,"tongue: 6.9 nTPM (protected, limit 2); rectum: 6.8 nTPM (protected, limit 2); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196391,ZNF774,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.7097% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.9012% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.4286% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.1111% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 51.8868% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 54.4554% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.9375% (minimum 99%, Baseline (adaptation disabled)); colon: 55.5556% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.5128% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.8824% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.0732% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.7059% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.8824% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.3016% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.4286% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.1398% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.7059% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 65.4762% (minimum 99%, Baseline (adaptation disabled)); rectum: 44.7154% (minimum 97%, Baseline (adaptation disabled)); retina: 57.2917% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.1398% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 48.2456% (minimum 99%, Baseline (adaptation disabled)); skin: 64.7059% (minimum 95%, Baseline (adaptation disabled)); small intestine: 73.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.3889% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.3889% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.1639% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.9012% (minimum 97%, Baseline (adaptation disabled)); thymus: 78.5714% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 67.0732% (minimum 95%, Baseline (adaptation disabled)); tongue: 44.3548% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.3425% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.9,6.9,3,"tongue: 6.9 nTPM (protected, limit 2); rectum: 6.8 nTPM (protected, limit 2); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196391,ZNF774,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.302941,-0.526452,-0.507544
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 88.7097% (minimum 95%, Missing); adrenal gland: 67.9012% (minimum 99%, Missing); amygdala: 71.4286% (minimum 99%, Missing); basal ganglia: 61.1111% (minimum 99%, Missing); bone marrow: 83.3333% (minimum 99%, Missing); cerebellum: 51.8868% (minimum 99%, Missing); cerebral cortex: 54.4554% (minimum 99%, Missing); choroid plexus: 85.9375% (minimum 99%, Missing); colon: 55.5556% (minimum 97%, Missing); duodenum: 70.5128% (minimum 99%, Missing); esophagus: 80.8824% (minimum 97%, Missing); heart muscle: 67.0732% (minimum 99%, Missing); hippocampal formation: 73.3333% (minimum 99%, Missing); hypothalamus: 64.7059% (minimum 99%, Missing); kidney: 80.8824% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 87.3016% (minimum 97%, Missing); midbrain: 71.4286% (minimum 99%, Missing); pancreas: 59.1398% (minimum 99%, Missing); parathyroid gland: 64.7059% (minimum 97%, Missing); pituitary gland: 65.4762% (minimum 99%, Missing); rectum: 44.7154% (minimum 97%, Missing); retina: 57.2917% (minimum 99%, Missing); salivary gland: 59.1398% (minimum 97%, Missing); skeletal muscle: 48.2456% (minimum 99%, Missing); skin: 64.7059% (minimum 95%, Missing); small intestine: 73.3333% (minimum 99%, Missing); smooth muscle: 76.3889% (minimum 99%, Missing); spinal cord: 76.3889% (minimum 99%, Missing); spleen: 90.1639% (minimum 95%, Missing); stomach: 67.9012% (minimum 97%, Missing); thymus: 78.5714% (minimum 95%, Missing); thyroid gland: 67.0732% (minimum 95%, Missing); tongue: 44.3548% (minimum 97%, Missing); urinary bladder: 75.3425% (minimum 97%, Missing)",0,80,unavailable,5.9,6.9,3,"tongue: 6.9 nTPM (protected, limit 2); rectum: 6.8 nTPM (protected, limit 2); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 2); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); parathyroid gland: 3 nTPM (protected, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196391,ZNF774,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.302941,-0.526452,-0.507544
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000196406,SPANXD,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000196406,SPANXD,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000196406,SPANXD,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.4,8.5,4.2,"parathyroid gland: 8.5 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196417,ZNF765,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.2381% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.1034% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.0426% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.9462% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 65.8333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.9462% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.9462% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.9462% (minimum 99%, Baseline (adaptation disabled)); colon: 70.5357% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.4771% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.9615% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.6122% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.0426% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.0426% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.5283% (minimum 99%, Baseline (adaptation disabled)); liver: 80.6122% (minimum 99%, Baseline (adaptation disabled)); lung: 72.4771% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.5214% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.1579% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.2276% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 48.1707% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.6122% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.6957% (minimum 97%, Baseline (adaptation disabled)); retina: 79.7980% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.5283% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.2917% (minimum 99%, Baseline (adaptation disabled)); skin: 66.3866% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.5283% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 79.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.7980% (minimum 99%, Baseline (adaptation disabled)); spleen: 71.1712% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.8318% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.2893% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.8182% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.0426% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.2381% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.4,8.5,4.2,"parathyroid gland: 8.5 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196417,ZNF765,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.297107,-0.488293,-0.347724
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.2381% (minimum 95%, Missing); adrenal gland: 68.1034% (minimum 99%, Missing); amygdala: 84.0426% (minimum 99%, Missing); basal ganglia: 84.9462% (minimum 99%, Missing); bone marrow: 65.8333% (minimum 99%, Missing); cerebellum: 84.9462% (minimum 99%, Missing); cerebral cortex: 84.9462% (minimum 99%, Missing); choroid plexus: 84.9462% (minimum 99%, Missing); colon: 70.5357% (minimum 97%, Missing); duodenum: 72.4771% (minimum 99%, Missing); esophagus: 75.9615% (minimum 97%, Missing); heart muscle: 80.6122% (minimum 99%, Missing); hippocampal formation: 84.0426% (minimum 99%, Missing); hypothalamus: 84.0426% (minimum 99%, Missing); kidney: 74.5283% (minimum 99%, Missing); liver: 80.6122% (minimum 99%, Missing); lung: 72.4771% (minimum 99%, Missing); lymph node: 67.5214% (minimum 97%, Missing); midbrain: 83.1579% (minimum 99%, Missing); pancreas: 64.2276% (minimum 99%, Missing); parathyroid gland: 48.1707% (minimum 97%, Missing); pituitary gland: 80.6122% (minimum 99%, Missing); rectum: 68.6957% (minimum 97%, Missing); retina: 79.7980% (minimum 99%, Missing); salivary gland: 74.5283% (minimum 97%, Missing); skeletal muscle: 82.2917% (minimum 99%, Missing); skin: 66.3866% (minimum 95%, Missing); small intestine: 74.5283% (minimum 99%, Missing); smooth muscle: 79.0000% (minimum 99%, Missing); spinal cord: 79.7980% (minimum 99%, Missing); spleen: 71.1712% (minimum 95%, Missing); stomach: 73.8318% (minimum 97%, Missing); thymus: 65.2893% (minimum 95%, Missing); thyroid gland: 71.8182% (minimum 95%, Missing); tongue: 84.0426% (minimum 97%, Missing); urinary bladder: 75.2381% (minimum 97%, Missing)",0,80,unavailable,4.4,8.5,4.2,"parathyroid gland: 8.5 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 2); adrenal gland: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); salivary gland: 2.7 nTPM (protected, limit 2); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); esophagus: 2.5 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196417,ZNF765,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.297107,-0.488293,-0.347724
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.3,6,5.9,"colon: 6 nTPM (protected, limit 2); thymus: 5.9 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); liver: 2.7 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196418,ZNF124,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.7119% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.0714% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.5102% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.0833% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 45.1220% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.5185% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.8113% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.4348% (minimum 99%, Baseline (adaptation disabled)); colon: 38.1443% (minimum 97%, Baseline (adaptation disabled)); duodenum: 41.1111% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.5185% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.5185% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.5490% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.8113% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.6842% (minimum 99%, Baseline (adaptation disabled)); liver: 57.8125% (minimum 99%, Baseline (adaptation disabled)); lung: 52.1127% (minimum 99%, Baseline (adaptation disabled)); lymph node: 42.0455% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.8113% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.8571% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 74.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.7234% (minimum 99%, Baseline (adaptation disabled)); rectum: 40.2174% (minimum 97%, Baseline (adaptation disabled)); retina: 54.4118% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.7931% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.1538% (minimum 99%, Baseline (adaptation disabled)); skin: 55.2239% (minimum 95%, Baseline (adaptation disabled)); small intestine: 41.5730% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.0606% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.0714% (minimum 99%, Baseline (adaptation disabled)); spleen: 44.0476% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 38.5417% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.0606% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.5102% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.8125% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.3,6,5.9,"colon: 6 nTPM (protected, limit 2); thymus: 5.9 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); liver: 2.7 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196418,ZNF124,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.564583,-0.588557,-0.578889
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.7119% (minimum 95%, Missing); adrenal gland: 66.0714% (minimum 99%, Missing); amygdala: 75.5102% (minimum 99%, Missing); basal ganglia: 77.0833% (minimum 99%, Missing); bone marrow: 45.1220% (minimum 99%, Missing); cerebellum: 68.5185% (minimum 99%, Missing); cerebral cortex: 69.8113% (minimum 99%, Missing); choroid plexus: 80.4348% (minimum 99%, Missing); colon: 38.1443% (minimum 97%, Missing); duodenum: 41.1111% (minimum 99%, Missing); esophagus: 68.5185% (minimum 97%, Missing); heart muscle: 68.5185% (minimum 99%, Missing); hippocampal formation: 72.5490% (minimum 99%, Missing); hypothalamus: 69.8113% (minimum 99%, Missing); kidney: 48.6842% (minimum 99%, Missing); liver: 57.8125% (minimum 99%, Missing); lung: 52.1127% (minimum 99%, Missing); lymph node: 42.0455% (minimum 97%, Missing); midbrain: 69.8113% (minimum 99%, Missing); pancreas: 52.8571% (minimum 99%, Missing); parathyroid gland: 74.0000% (minimum 97%, Missing); pituitary gland: 78.7234% (minimum 99%, Missing); rectum: 40.2174% (minimum 97%, Missing); retina: 54.4118% (minimum 99%, Missing); salivary gland: 63.7931% (minimum 97%, Missing); skeletal muscle: 71.1538% (minimum 99%, Missing); skin: 55.2239% (minimum 95%, Missing); small intestine: 41.5730% (minimum 99%, Missing); smooth muscle: 56.0606% (minimum 99%, Missing); spinal cord: 66.0714% (minimum 99%, Missing); spleen: 44.0476% (minimum 95%, Missing); stomach: 50.0000% (minimum 97%, Missing); thymus: 38.5417% (minimum 95%, Missing); thyroid gland: 56.0606% (minimum 95%, Missing); tongue: 75.5102% (minimum 97%, Missing); urinary bladder: 57.8125% (minimum 97%, Missing)",0,80,unavailable,5.3,6,5.9,"colon: 6 nTPM (protected, limit 2); thymus: 5.9 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 2); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 2); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); urinary bladder: 2.7 nTPM (protected, limit 2); liver: 2.7 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196418,ZNF124,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.564583,-0.588557,-0.578889
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,1.1,0.3,0.2,"small intestine: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,ENSG00000196427,NBPF4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 93.4783% (minimum 99%, Baseline (adaptation disabled)); colon: 95.5556% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.7273% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 87.7551% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.4783% (minimum 97%, Baseline (adaptation disabled)); small intestine: 79.6296% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,1.1,0.3,0.2,"small intestine: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,ENSG00000196427,NBPF4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.00555556,-0.0352174,-0.193704
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 93.4783% (minimum 99%, Missing); colon: 95.5556% (minimum 97%, Uncertain); duodenum: 97.7273% (minimum 99%, Uncertain); pituitary gland: 87.7551% (minimum 99%, Missing); rectum: 93.4783% (minimum 97%, Uncertain); small intestine: 79.6296% (minimum 99%, Uncertain)",0,1,partial,1.1,0.3,0.2,"small intestine: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,ENSG00000196427,NBPF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.00555556,-0.0352174,-0.193704
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,0.2,0.1,0.2,,eye / lens fiber cells: High (Supported),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; spleen; thymus; tonsil,ENSG00000196431,CRYBA4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 93.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.3333% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 87.5000% (minimum 95%, Baseline (adaptation disabled)); thymus: 93.3333% (minimum 95%, Baseline (adaptation disabled))",0,0,routine_complete,0.2,0.1,0.2,,eye / lens fiber cells: High (Supported),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; spleen; thymus; tonsil,ENSG00000196431,CRYBA4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.075,-0.0366667,-0.115
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.3333% (minimum 99%, Missing); basal ganglia: 93.3333% (minimum 99%, Missing); bone marrow: 93.3333% (minimum 97%, Supported); cerebral cortex: 93.3333% (minimum 97%, Supported); duodenum: 87.5000% (minimum 97%, Supported); hippocampal formation: 93.3333% (minimum 99%, Missing); hypothalamus: 93.3333% (minimum 99%, Missing); midbrain: 93.3333% (minimum 99%, Missing); thymus: 93.3333% (minimum 95%, Missing)",0,0,routine_complete,0.2,0.1,0.2,,eye / lens fiber cells: High (Supported),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; spleen; thymus; tonsil,ENSG00000196431,CRYBA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0166667,0.03,-0.095
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,13.3,4.5,5.4,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); hypothalamus: 4.4 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); urinary bladder: 2.1 nTPM (protected, limit 2); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196437,ZNF569,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.8116% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.6027% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.1773% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.1259% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 70.1987% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.8385% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.2810% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.3030% (minimum 99%, Baseline (adaptation disabled)); colon: 82.8125% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.6033% (minimum 99%, Baseline (adaptation disabled)); esophagus: 82.8125% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.1088% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.3723% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.7143% (minimum 99%, Baseline (adaptation disabled)); liver: 76.8116% (minimum 99%, Baseline (adaptation disabled)); lung: 81.5385% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.1034% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.1773% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.4839% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.1409% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.8116% (minimum 99%, Baseline (adaptation disabled)); rectum: 86.1789% (minimum 97%, Baseline (adaptation disabled)); retina: 44.3515% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.8125% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.6216% (minimum 99%, Baseline (adaptation disabled)); skin: 77.3723% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.1789% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.2590% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.6479% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.2590% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.8125% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.9487% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 66.2500% (minimum 95%, Baseline (adaptation disabled)); tongue: 70.1987% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.4646% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,13.3,4.5,5.4,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); hypothalamus: 4.4 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); urinary bladder: 2.1 nTPM (protected, limit 2); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196437,ZNF569,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.2875,-0.268013,-0.546485
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.8116% (minimum 95%, Missing); adrenal gland: 72.6027% (minimum 99%, Missing); amygdala: 75.1773% (minimum 99%, Missing); basal ganglia: 74.1259% (minimum 99%, Missing); bone marrow: 70.1987% (minimum 99%, Missing); cerebellum: 65.8385% (minimum 99%, Missing); cerebral cortex: 69.2810% (minimum 99%, Missing); choroid plexus: 80.3030% (minimum 99%, Missing); colon: 82.8125% (minimum 97%, Missing); duodenum: 87.6033% (minimum 99%, Missing); esophagus: 82.8125% (minimum 97%, Missing); heart muscle: 72.1088% (minimum 99%, Missing); hippocampal formation: 77.3723% (minimum 99%, Missing); hypothalamus: 70.6667% (minimum 99%, Missing); kidney: 75.7143% (minimum 99%, Missing); liver: 76.8116% (minimum 99%, Missing); lung: 81.5385% (minimum 99%, Missing); lymph node: 73.1034% (minimum 97%, Missing); midbrain: 75.1773% (minimum 99%, Missing); pancreas: 85.4839% (minimum 99%, Missing); parathyroid gland: 71.1409% (minimum 97%, Missing); pituitary gland: 76.8116% (minimum 99%, Missing); rectum: 86.1789% (minimum 97%, Missing); retina: 44.3515% (minimum 99%, Missing); salivary gland: 82.8125% (minimum 97%, Missing); skeletal muscle: 71.6216% (minimum 99%, Missing); skin: 77.3723% (minimum 95%, Missing); small intestine: 86.1789% (minimum 99%, Missing); smooth muscle: 76.2590% (minimum 99%, Missing); spinal cord: 74.6479% (minimum 99%, Missing); spleen: 76.2590% (minimum 95%, Missing); stomach: 82.8125% (minimum 97%, Missing); thymus: 67.9487% (minimum 95%, Missing); thyroid gland: 66.2500% (minimum 95%, Missing); tongue: 70.1987% (minimum 97%, Missing); urinary bladder: 83.4646% (minimum 97%, Missing)",0,80,unavailable,13.3,4.5,5.4,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 2); hypothalamus: 4.4 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); urinary bladder: 2.1 nTPM (protected, limit 2); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196437,ZNF569,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.2875,-0.268013,-0.546485
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.7,0.3,0.7,"bone marrow: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000196460,RFX8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.7059% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 22.9167% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.6667% (minimum 99%, Baseline (adaptation disabled)); duodenum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.6154% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.5714% (minimum 97%, Baseline (adaptation disabled)); parathyroid gland: 91.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.6667% (minimum 97%, Baseline (adaptation disabled)); skin: 84.6154% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); thymus: 61.1111% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.7500% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.7,0.3,0.7,"bone marrow: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000196460,RFX8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.338889,-0.184286,-0.760833
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.7059% (minimum 95%, Missing); adrenal gland: 91.6667% (minimum 99%, Missing); basal ganglia: 91.6667% (minimum 99%, Missing); bone marrow: 22.9167% (minimum 99%, Missing); cerebral cortex: 91.6667% (minimum 99%, Missing); duodenum: 91.6667% (minimum 99%, Missing); esophagus: 91.6667% (minimum 97%, Missing); heart muscle: 84.6154% (minimum 99%, Missing); hypothalamus: 91.6667% (minimum 99%, Missing); kidney: 91.6667% (minimum 99%, Missing); lung: 91.6667% (minimum 99%, Missing); lymph node: 78.5714% (minimum 97%, Missing); parathyroid gland: 91.6667% (minimum 97%, Missing); pituitary gland: 91.6667% (minimum 99%, Missing); salivary gland: 91.6667% (minimum 97%, Missing); skin: 84.6154% (minimum 95%, Missing); smooth muscle: 91.6667% (minimum 99%, Missing); thymus: 61.1111% (minimum 95%, Missing); thyroid gland: 68.7500% (minimum 95%, Missing)",0,80,unavailable,3.7,0.3,0.7,"bone marrow: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000196460,RFX8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.338889,-0.184286,-0.760833
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,3.7,2.6,3.1,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); lymph node: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); tongue: 2.2 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196466,ZNF799,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.1622% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.1622% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.0159% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.8750% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.4098% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.7692% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.3103% (minimum 99%, Baseline (adaptation disabled)); colon: 64.7887% (minimum 97%, Baseline (adaptation disabled)); duodenum: 68.6567% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.8750% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.6970% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.7692% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.0159% (minimum 99%, Baseline (adaptation disabled)); kidney: 58.2278% (minimum 99%, Baseline (adaptation disabled)); liver: 55.4217% (minimum 99%, Baseline (adaptation disabled)); lung: 62.1622% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.7887% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.7692% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.6567% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.1429% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.7887% (minimum 97%, Baseline (adaptation disabled)); retina: 75.4098% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.6567% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.8750% (minimum 99%, Baseline (adaptation disabled)); skin: 66.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.7692% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.7692% (minimum 97%, Baseline (adaptation disabled)); thymus: 59.7403% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 70.7692% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.6471% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.8889% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,3.7,2.6,3.1,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); lymph node: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); tongue: 2.2 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196466,ZNF799,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.352597,-0.331111,-0.435783
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.1622% (minimum 95%, Missing); adrenal gland: 62.1622% (minimum 99%, Missing); amygdala: 73.0159% (minimum 99%, Missing); basal ganglia: 71.8750% (minimum 99%, Missing); bone marrow: 75.4098% (minimum 99%, Missing); cerebellum: 70.7692% (minimum 99%, Missing); cerebral cortex: 76.6667% (minimum 99%, Missing); choroid plexus: 79.3103% (minimum 99%, Missing); colon: 64.7887% (minimum 97%, Missing); duodenum: 68.6567% (minimum 99%, Missing); esophagus: 71.8750% (minimum 97%, Missing); heart muscle: 69.6970% (minimum 99%, Missing); hippocampal formation: 70.7692% (minimum 99%, Missing); hypothalamus: 73.0159% (minimum 99%, Missing); kidney: 58.2278% (minimum 99%, Missing); liver: 55.4217% (minimum 99%, Missing); lung: 62.1622% (minimum 99%, Missing); lymph node: 64.7887% (minimum 97%, Missing); midbrain: 70.7692% (minimum 99%, Missing); pancreas: 68.6567% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 82.1429% (minimum 99%, Missing); rectum: 64.7887% (minimum 97%, Missing); retina: 75.4098% (minimum 99%, Missing); salivary gland: 68.6567% (minimum 97%, Missing); skeletal muscle: 71.8750% (minimum 99%, Missing); skin: 66.6667% (minimum 95%, Missing); small intestine: 65.7143% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 70.7692% (minimum 99%, Missing); spleen: 61.3333% (minimum 95%, Missing); stomach: 70.7692% (minimum 97%, Missing); thymus: 59.7403% (minimum 95%, Missing); thyroid gland: 70.7692% (minimum 95%, Missing); tongue: 67.6471% (minimum 97%, Missing); urinary bladder: 63.8889% (minimum 97%, Missing)",0,3,partial,3.7,2.6,3.1,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); urinary bladder: 2.6 nTPM (protected, limit 2); colon: 2.5 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); lymph node: 2.5 nTPM (protected, limit 2); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); tongue: 2.2 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196466,ZNF799,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.352597,-0.331111,-0.435783
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,27.8,16.6,22.5,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); liver: 22 nTPM (vital, limit 1); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (manageable, limit 5); tongue: 16.6 nTPM (protected, limit 2); small intestine: 15.8 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 2); colon: 15.5 nTPM (protected, limit 2); duodenum: 15.5 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); stomach: 15.3 nTPM (protected, limit 2); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); kidney: 14.1 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 2); hippocampal formation: 14.1 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.7 nTPM (protected, limit 2); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 2); esophagus: 13.6 nTPM (protected, limit 2); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); spleen: 13.1 nTPM (manageable, limit 5); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196470,SIAH1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.2652% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 77.9388% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.6992% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.6053% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 63.5171% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.1930% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.9812% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.5924% (minimum 99%, Baseline (adaptation disabled)); colon: 75.7433% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.7433% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.0645% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.0701% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.4400% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.4441% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.4400% (minimum 99%, Baseline (adaptation disabled)); liver: 68.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 73.8931% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.0645% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.5714% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.9388% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.4400% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.7350% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.4400% (minimum 97%, Baseline (adaptation disabled)); retina: 72.3468% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.6250% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.9422% (minimum 99%, Baseline (adaptation disabled)); skin: 69.1429% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.3894% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 77.5641% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.8254% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.6992% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.9812% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.9388% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 74.0061% (minimum 95%, Baseline (adaptation disabled)); tongue: 74.4615% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 77.9388% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,27.8,16.6,22.5,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); liver: 22 nTPM (vital, limit 1); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (manageable, limit 5); tongue: 16.6 nTPM (protected, limit 2); small intestine: 15.8 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 2); colon: 15.5 nTPM (protected, limit 2); duodenum: 15.5 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); stomach: 15.3 nTPM (protected, limit 2); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); kidney: 14.1 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 2); hippocampal formation: 14.1 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.7 nTPM (protected, limit 2); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 2); esophagus: 13.6 nTPM (protected, limit 2); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); spleen: 13.1 nTPM (manageable, limit 5); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196470,SIAH1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.267348,-0.225385,-0.354829
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 68.2652% (minimum 95%, Missing); adrenal gland: 77.9388% (minimum 99%, Missing); amygdala: 78.6992% (minimum 99%, Missing); basal ganglia: 79.6053% (minimum 99%, Missing); bone marrow: 63.5171% (minimum 99%, Missing); cerebellum: 77.1930% (minimum 99%, Missing); cerebral cortex: 75.9812% (minimum 99%, Missing); choroid plexus: 83.5924% (minimum 99%, Missing); colon: 75.7433% (minimum 97%, Missing); duodenum: 75.7433% (minimum 99%, Missing); esophagus: 78.0645% (minimum 97%, Missing); heart muscle: 77.0701% (minimum 99%, Missing); hippocampal formation: 77.4400% (minimum 99%, Missing); hypothalamus: 78.4441% (minimum 99%, Missing); kidney: 77.4400% (minimum 99%, Missing); liver: 68.7500% (minimum 99%, Missing); lung: 73.8931% (minimum 99%, Missing); lymph node: 78.0645% (minimum 97%, Missing); midbrain: 78.5714% (minimum 99%, Missing); pancreas: 77.9388% (minimum 99%, Missing); parathyroid gland: 77.4400% (minimum 97%, Missing); pituitary gland: 82.7350% (minimum 99%, Missing); rectum: 77.4400% (minimum 97%, Missing); retina: 72.3468% (minimum 99%, Missing); salivary gland: 75.6250% (minimum 97%, Missing); skeletal muscle: 69.9422% (minimum 99%, Missing); skin: 69.1429% (minimum 95%, Missing); small intestine: 75.3894% (minimum 99%, Missing); smooth muscle: 77.5641% (minimum 99%, Missing); spinal cord: 76.8254% (minimum 99%, Missing); spleen: 78.6992% (minimum 95%, Missing); stomach: 75.9812% (minimum 97%, Missing); thymus: 77.9388% (minimum 95%, Missing); thyroid gland: 74.0061% (minimum 95%, Missing); tongue: 74.4615% (minimum 97%, Missing); urinary bladder: 77.9388% (minimum 97%, Missing)",0,4,partial,27.8,16.6,22.5,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); liver: 22 nTPM (vital, limit 1); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (manageable, limit 5); tongue: 16.6 nTPM (protected, limit 2); small intestine: 15.8 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 2); colon: 15.5 nTPM (protected, limit 2); duodenum: 15.5 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); stomach: 15.3 nTPM (protected, limit 2); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 2); kidney: 14.1 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 2); hippocampal formation: 14.1 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.7 nTPM (protected, limit 2); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 2); esophagus: 13.6 nTPM (protected, limit 2); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); spleen: 13.1 nTPM (manageable, limit 5); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196470,SIAH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.267348,-0.225385,-0.354829
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196475,GK2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196475,GK2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196475,GK2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,7.9,4.7,4.5,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); pancreas: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); stomach: 4.2 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); salivary gland: 2.9 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000196505,GDAP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.9661% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.9661% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 36.8000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.1935% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.6970% (minimum 99%, Baseline (adaptation disabled)); colon: 56.0976% (minimum 97%, Baseline (adaptation disabled)); duodenum: 54.1176% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.5263% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.7143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.9661% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 48.4211% (minimum 99%, Baseline (adaptation disabled)); lung: 58.2278% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.7901% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 51.6854% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.4624% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.6854% (minimum 97%, Baseline (adaptation disabled)); retina: 62.1622% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.8750% (minimum 99%, Baseline (adaptation disabled)); skin: 62.1622% (minimum 95%, Baseline (adaptation disabled)); small intestine: 50.5495% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.1622% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.4098% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.8736% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.2727% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.1176% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.5495% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.6970% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.6854% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,7.9,4.7,4.5,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 2); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); rectum: 4.3 nTPM (protected, limit 2); pancreas: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); lymph node: 3.5 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); salivary gland: 2.9 nTPM (protected, limit 2); retina: 2.8 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000196505,GDAP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.444505,-0.475376,-0.622
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.3333% (minimum 95%, Missing); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 77.9661% (minimum 99%, Missing); basal ganglia: 77.9661% (minimum 99%, Missing); bone marrow: 36.8000% (minimum 99%, Missing); cerebellum: 76.6667% (minimum 99%, Missing); cerebral cortex: 74.1935% (minimum 99%, Missing); choroid plexus: 69.6970% (minimum 99%, Missing); colon: 56.0976% (minimum 97%, Missing); duodenum: 54.1176% (minimum 99%, Missing); esophagus: 60.5263% (minimum 97%, Missing); heart muscle: 65.7143% (minimum 99%, Missing); hippocampal formation: 77.9661% (minimum 99%, Missing); hypothalamus: 76.6667% (minimum 99%, Missing); kidney: 50.0000% (minimum 99%, Missing); liver: 48.4211% (minimum 98%, Approved); lung: 58.2278% (minimum 99%, Missing); lymph node: 56.7901% (minimum 95%, Approved); midbrain: 76.6667% (minimum 99%, Missing); pancreas: 51.6854% (minimum 99%, Missing); parathyroid gland: 49.4624% (minimum 95%, Approved); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 51.6854% (minimum 97%, Missing); retina: 62.1622% (minimum 99%, Missing); salivary gland: 61.3333% (minimum 97%, Missing); skeletal muscle: 71.8750% (minimum 98%, Approved); skin: 62.1622% (minimum 95%, Missing); small intestine: 50.5495% (minimum 99%, Missing); smooth muscle: 62.1622% (minimum 98%, Approved); spinal cord: 75.4098% (minimum 99%, Missing); spleen: 52.8736% (minimum 90%, Approved); stomach: 52.2727% (minimum 97%, Missing); thymus: 54.1176% (minimum 95%, Missing); thyroid gland: 50.5495% (minimum 95%, Missing); tongue: 69.6970% (minimum 97%, Missing); urinary bladder: 51.6854% (minimum 97%, Missing)",0,4,partial,7.9,4.7,4.5,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); pancreas: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 2); stomach: 4.2 nTPM (protected, limit 2); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); esophagus: 3 nTPM (protected, limit 2); salivary gland: 2.9 nTPM (protected, limit 2); smooth muscle: 2.8 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000196505,GDAP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.444505,-0.455376,-0.622
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,13.6,6.1,7.7,"duodenum: 13.6 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); lymph node: 5.6 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196511,TPK1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.9451% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.2410% (minimum 99%, Baseline (adaptation disabled)); amygdala: 69.4444% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.4286% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.9351% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.6269% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.2410% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 51.5464% (minimum 99%, Baseline (adaptation disabled)); colon: 45.0450% (minimum 97%, Baseline (adaptation disabled)); duodenum: 26.8817% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.5294% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.7284% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.4286% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.9351% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.8182% (minimum 99%, Baseline (adaptation disabled)); liver: 54.3478% (minimum 99%, Baseline (adaptation disabled)); lung: 50.5051% (minimum 99%, Baseline (adaptation disabled)); lymph node: 47.1698% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.4444% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.4638% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 74.6269% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.1250% (minimum 99%, Baseline (adaptation disabled)); rectum: 46.2963% (minimum 97%, Baseline (adaptation disabled)); retina: 69.4444% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 58.8235% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 75.7576% (minimum 99%, Baseline (adaptation disabled)); skin: 79.3651% (minimum 95%, Baseline (adaptation disabled)); small intestine: 40.9836% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 59.5238% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.5676% (minimum 99%, Baseline (adaptation disabled)); spleen: 39.3701% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.4225% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.9351% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.5000% (minimum 95%, Baseline (adaptation disabled)); tongue: 64.1026% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.1798% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,13.6,6.1,7.7,"duodenum: 13.6 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); lymph node: 5.6 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196511,TPK1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.556299,-0.51955,-0.721183
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.9451% (minimum 95%, Missing); adrenal gland: 60.2410% (minimum 99%, Missing); amygdala: 69.4444% (minimum 99%, Missing); basal ganglia: 71.4286% (minimum 99%, Missing); bone marrow: 64.9351% (minimum 99%, Missing); cerebellum: 74.6269% (minimum 99%, Missing); cerebral cortex: 60.2410% (minimum 99%, Missing); choroid plexus: 51.5464% (minimum 99%, Missing); colon: 45.0450% (minimum 97%, Missing); duodenum: 26.8817% (minimum 99%, Missing); esophagus: 73.5294% (minimum 97%, Missing); heart muscle: 61.7284% (minimum 99%, Missing); hippocampal formation: 71.4286% (minimum 99%, Missing); hypothalamus: 64.9351% (minimum 99%, Missing); kidney: 56.8182% (minimum 99%, Missing); liver: 54.3478% (minimum 99%, Missing); lung: 50.5051% (minimum 99%, Missing); lymph node: 47.1698% (minimum 97%, Missing); midbrain: 69.4444% (minimum 99%, Missing); pancreas: 72.4638% (minimum 99%, Missing); parathyroid gland: 74.6269% (minimum 97%, Missing); pituitary gland: 78.1250% (minimum 99%, Missing); rectum: 46.2963% (minimum 97%, Missing); retina: 69.4444% (minimum 99%, Missing); salivary gland: 58.8235% (minimum 97%, Missing); skeletal muscle: 75.7576% (minimum 99%, Missing); skin: 79.3651% (minimum 95%, Missing); small intestine: 40.9836% (minimum 99%, Missing); smooth muscle: 59.5238% (minimum 99%, Missing); spinal cord: 67.5676% (minimum 99%, Missing); spleen: 39.3701% (minimum 95%, Missing); stomach: 70.4225% (minimum 97%, Missing); thymus: 64.9351% (minimum 95%, Missing); thyroid gland: 62.5000% (minimum 95%, Missing); tongue: 64.1026% (minimum 97%, Missing); urinary bladder: 56.1798% (minimum 97%, Missing)",0,2,partial,13.6,6.1,7.7,"duodenum: 13.6 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 2); rectum: 5.8 nTPM (protected, limit 2); lymph node: 5.6 nTPM (protected, limit 2); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); tongue: 2.8 nTPM (protected, limit 2); hypothalamus: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196511,TPK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.556299,-0.51955,-0.721183
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.5,10.7,8.4,"lymph node: 10.7 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); spleen: 6.1 nTPM (manageable, limit 5); skin: 5.9 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); hippocampal formation: 2.4 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196550,FAM72A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.8889% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.1765% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 44.8052% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.6452% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.3103% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.1463% (minimum 99%, Baseline (adaptation disabled)); colon: 75.8242% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.4082% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.4043% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.2500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.1935% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.3103% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.1463% (minimum 99%, Baseline (adaptation disabled)); liver: 77.5281% (minimum 99%, Baseline (adaptation disabled)); lung: 72.6316% (minimum 99%, Baseline (adaptation disabled)); lymph node: 39.2045% (minimum 97%, Baseline (adaptation disabled)); midbrain: 72.6316% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.1429% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.1429% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 89.6104% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 97.1831% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.3418% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.2432% (minimum 99%, Baseline (adaptation disabled)); skin: 53.9062% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.4082% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.4091% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.8750% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.0769% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.1765% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.0980% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 89.6104% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.3418% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.1429% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.5,10.7,8.4,"lymph node: 10.7 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); spleen: 6.1 nTPM (manageable, limit 5); skin: 5.9 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); hippocampal formation: 2.4 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196550,FAM72A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.49902,-0.577955,-0.541948
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.8889% (minimum 95%, Missing); adrenal gland: 69.0000% (minimum 99%, Missing); amygdala: 76.6667% (minimum 99%, Missing); basal ganglia: 81.1765% (minimum 99%, Missing); bone marrow: 44.8052% (minimum 99%, Missing); cerebellum: 55.6452% (minimum 99%, Missing); cerebral cortex: 79.3103% (minimum 99%, Missing); choroid plexus: 84.1463% (minimum 99%, Missing); colon: 75.8242% (minimum 97%, Missing); duodenum: 70.4082% (minimum 99%, Missing); esophagus: 73.4043% (minimum 97%, Missing); heart muscle: 86.2500% (minimum 99%, Missing); hippocampal formation: 74.1935% (minimum 99%, Missing); hypothalamus: 79.3103% (minimum 99%, Missing); kidney: 84.1463% (minimum 99%, Missing); liver: 77.5281% (minimum 99%, Missing); lung: 72.6316% (minimum 99%, Missing); lymph node: 39.2045% (minimum 97%, Missing); midbrain: 72.6316% (minimum 99%, Missing); pancreas: 82.1429% (minimum 99%, Missing); parathyroid gland: 82.1429% (minimum 97%, Missing); pituitary gland: 89.6104% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 97.1831% (minimum 99%, Missing); salivary gland: 87.3418% (minimum 97%, Missing); skeletal muscle: 93.2432% (minimum 99%, Missing); skin: 53.9062% (minimum 95%, Missing); small intestine: 70.4082% (minimum 99%, Missing); smooth muscle: 78.4091% (minimum 99%, Missing); spinal cord: 71.8750% (minimum 99%, Missing); spleen: 53.0769% (minimum 95%, Missing); stomach: 81.1765% (minimum 97%, Missing); thymus: 45.0980% (minimum 95%, Missing); thyroid gland: 89.6104% (minimum 95%, Missing); tongue: 87.3418% (minimum 97%, Missing); urinary bladder: 82.1429% (minimum 97%, Missing)",0,80,unavailable,8.5,10.7,8.4,"lymph node: 10.7 nTPM (protected, limit 2); bone marrow: 8.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); spleen: 6.1 nTPM (manageable, limit 5); skin: 5.9 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); hippocampal formation: 2.4 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196550,FAM72A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.49902,-0.577955,-0.541948
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000196553,CCDC196,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.1481% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000196553,CCDC196,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021;Loriot 2025,0.05,0.03,-0.00851852
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.1481% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000196553,CCDC196,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021;Loriot 2025,0.05,0.03,-0.00851852
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,77,3.7,26.7,"bone marrow: 77 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 10); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 2); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 2); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 2); skeletal muscle: 4 nTPM (vital, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 2); cerebellum: 2.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196565,HBG2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0,2,partial,77,3.7,26.7,"bone marrow: 77 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); adipose tissue: 6.6 nTPM (manageable, limit 5); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 2); hypothalamus: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196565,HBG2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0473241,0.0296283,0.00232181
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0,2,partial,77,3.7,26.7,"bone marrow: 77 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 10); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 2); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 2); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 2); skeletal muscle: 4 nTPM (vital, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 2); cerebellum: 2.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196565,HBG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0497689,0.0299498,0.00232181
True,compatible,,True,True,False,,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000196570,PFN3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 96.5251% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000196570,PFN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,-0.024749
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 96.5251% (minimum 99%, Missing)",0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000196570,PFN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,-0.024749
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196578,OR5AC2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196578,OR5AC2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000196578,OR5AC2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.7,3.1,3.8,"bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196584,XRCC2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.8421% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 36.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.8421% (minimum 99%, Baseline (adaptation disabled)); colon: 73.3333% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.7059% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.7391% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.8421% (minimum 99%, Baseline (adaptation disabled)); liver: 82.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 84.6154% (minimum 99%, Baseline (adaptation disabled)); lymph node: 51.5625% (minimum 97%, Baseline (adaptation disabled)); pancreas: 91.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 84.6154% (minimum 97%, Baseline (adaptation disabled)); rectum: 63.4615% (minimum 97%, Baseline (adaptation disabled)); retina: 62.2642% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.1892% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.2857% (minimum 99%, Baseline (adaptation disabled)); skin: 61.1111% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.3469% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.5000% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.4789% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.5000% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.8421% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.8421% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.7,3.1,3.8,"bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196584,XRCC2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.485211,-0.454375,-0.623333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.8421% (minimum 95%, Missing); adrenal gland: 91.6667% (minimum 99%, Missing); bone marrow: 36.6667% (minimum 99%, Missing); cerebral cortex: 78.5714% (minimum 99%, Missing); choroid plexus: 86.8421% (minimum 99%, Missing); colon: 73.3333% (minimum 97%, Missing); duodenum: 64.7059% (minimum 99%, Missing); esophagus: 73.3333% (minimum 97%, Missing); heart muscle: 71.7391% (minimum 99%, Missing); kidney: 86.8421% (minimum 99%, Missing); liver: 82.5000% (minimum 99%, Missing); lung: 84.6154% (minimum 99%, Missing); lymph node: 51.5625% (minimum 97%, Missing); pancreas: 91.6667% (minimum 99%, Missing); parathyroid gland: 84.6154% (minimum 97%, Missing); rectum: 63.4615% (minimum 97%, Missing); retina: 62.2642% (minimum 99%, Missing); salivary gland: 89.1892% (minimum 97%, Missing); skeletal muscle: 94.2857% (minimum 99%, Missing); skin: 61.1111% (minimum 95%, Missing); small intestine: 67.3469% (minimum 99%, Missing); smooth muscle: 82.5000% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 73.3333% (minimum 97%, Missing); thymus: 46.4789% (minimum 95%, Missing); thyroid gland: 82.5000% (minimum 95%, Missing); tongue: 86.8421% (minimum 97%, Missing); urinary bladder: 86.8421% (minimum 97%, Missing)",0,80,unavailable,5.7,3.1,3.8,"bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196584,XRCC2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.485211,-0.454375,-0.623333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,9,3.1,3.9,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); stomach: 2.7 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196597,ZNF782,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.9474% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.5070% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.4157% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.1818% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.9231% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.1707% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.9474% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.5070% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.5070% (minimum 99%, Baseline (adaptation disabled)); kidney: 69.7674% (minimum 99%, Baseline (adaptation disabled)); liver: 77.9221% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.9655% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.7143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.6038% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.9341% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.9231% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.1818% (minimum 97%, Baseline (adaptation disabled)); retina: 40.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.1707% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 73.1707% (minimum 99%, Baseline (adaptation disabled)); skin: 60.6061% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.4157% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.1707% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.5070% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.1707% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.9655% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.5161% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.5161% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 80.0000% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,9,3.1,3.9,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); stomach: 2.7 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196597,ZNF782,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.343939,-0.310659,-0.59
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 78.9474% (minimum 99%, Missing); amygdala: 84.5070% (minimum 99%, Missing); basal ganglia: 83.3333% (minimum 99%, Missing); bone marrow: 80.0000% (minimum 99%, Missing); cerebellum: 67.4157% (minimum 99%, Missing); cerebral cortex: 68.1818% (minimum 99%, Missing); choroid plexus: 76.9231% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 73.1707% (minimum 99%, Missing); esophagus: 78.9474% (minimum 97%, Missing); heart muscle: 85.7143% (minimum 99%, Missing); hippocampal formation: 84.5070% (minimum 99%, Missing); hypothalamus: 84.5070% (minimum 99%, Missing); kidney: 69.7674% (minimum 99%, Missing); liver: 77.9221% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 68.9655% (minimum 97%, Missing); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 56.6038% (minimum 99%, Missing); parathyroid gland: 65.9341% (minimum 97%, Missing); pituitary gland: 76.9231% (minimum 99%, Missing); rectum: 68.1818% (minimum 97%, Missing); retina: 40.0000% (minimum 99%, Missing); salivary gland: 73.1707% (minimum 97%, Missing); skeletal muscle: 73.1707% (minimum 99%, Missing); skin: 60.6061% (minimum 95%, Missing); small intestine: 67.4157% (minimum 99%, Missing); smooth muscle: 73.1707% (minimum 99%, Missing); spinal cord: 84.5070% (minimum 99%, Missing); spleen: 73.1707% (minimum 95%, Missing); stomach: 68.9655% (minimum 97%, Missing); thymus: 64.5161% (minimum 95%, Missing); thyroid gland: 64.5161% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 80.0000% (minimum 97%, Missing)",0,2,partial,9,3.1,3.9,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); stomach: 2.7 nTPM (protected, limit 2); lymph node: 2.7 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000196597,ZNF782,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.343939,-0.310659,-0.59
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000196604,POTEF,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 89.4737% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000196604,POTEF,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,-0.0952632
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 89.4737% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000196604,POTEF,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,-0.0952632
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,10.1,12.7,7.6,"urinary bladder: 12.7 nTPM (protected, limit 2); smooth muscle: 10.1 nTPM (vital, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); colon: 7.9 nTPM (protected, limit 2); heart muscle: 7.9 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 4); thymus: 7.3 nTPM (manageable, limit 5); skin: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 4); salivary gland: 6.9 nTPM (protected, limit 2); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 4); retina: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 2); adrenal gland: 6.1 nTPM (vital, limit 2); hypothalamus: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 2); cerebellum: 3.9 nTPM (vital, limit 2); pancreas: 3.7 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000196605,ZNF846,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3125% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.6888% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.1707% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.5957% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.3571% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.1918% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.5862% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.2892% (minimum 99%, Baseline (adaptation disabled)); colon: 69.4981% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.4480% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.4981% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.1707% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.3138% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.6026% (minimum 99%, Baseline (adaptation disabled)); liver: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 73.1707% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.7674% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.7674% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.9493% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 72.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.9231% (minimum 99%, Baseline (adaptation disabled)); rectum: 72.5806% (minimum 97%, Baseline (adaptation disabled)); retina: 72.8745% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.2892% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.2609% (minimum 99%, Baseline (adaptation disabled)); skin: 71.1462% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.9221% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.0569% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.6934% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.3138% (minimum 95%, Baseline (adaptation disabled)); stomach: 74.0741% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.1462% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 73.1707% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.2532% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.6319% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,10.1,12.7,7.6,"urinary bladder: 12.7 nTPM (protected, limit 2); smooth muscle: 10.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); colon: 7.9 nTPM (protected, limit 2); heart muscle: 7.9 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 2); midbrain: 7.8 nTPM (vital, limit 1); adipose tissue: 7.6 nTPM (manageable, limit 5); thymus: 7.3 nTPM (manageable, limit 5); skin: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 2); salivary gland: 6.9 nTPM (protected, limit 2); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 2); retina: 6.7 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); hippocampal formation: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 2); adrenal gland: 6.1 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000196605,ZNF846,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.246875,-0.383681,-0.349431
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3125% (minimum 90%, Approved); adrenal gland: 74.6888% (minimum 98%, Approved); amygdala: 73.1707% (minimum 99%, Missing); basal ganglia: 76.5957% (minimum 99%, Missing); bone marrow: 80.3571% (minimum 99%, Missing); cerebellum: 82.1918% (minimum 98%, Approved); cerebral cortex: 77.5862% (minimum 99%, Missing); choroid plexus: 72.2892% (minimum 99%, Missing); colon: 69.4981% (minimum 97%, Missing); duodenum: 81.4480% (minimum 98%, Approved); esophagus: 66.6667% (minimum 97%, Missing); heart muscle: 69.4981% (minimum 99%, Missing); hippocampal formation: 73.1707% (minimum 99%, Missing); hypothalamus: 75.3138% (minimum 99%, Missing); kidney: 78.6026% (minimum 99%, Missing); liver: 80.0000% (minimum 98%, Approved); lung: 73.1707% (minimum 99%, Missing); lymph node: 69.7674% (minimum 95%, Approved); midbrain: 69.7674% (minimum 99%, Missing); pancreas: 82.9493% (minimum 98%, Approved); parathyroid gland: 72.0000% (minimum 95%, Approved); pituitary gland: 76.9231% (minimum 99%, Missing); rectum: 72.5806% (minimum 95%, Approved); retina: 72.8745% (minimum 99%, Missing); salivary gland: 72.2892% (minimum 97%, Missing); skeletal muscle: 78.2609% (minimum 99%, Missing); skin: 71.1462% (minimum 95%, Missing); small intestine: 77.9221% (minimum 99%, Missing); smooth muscle: 64.0569% (minimum 98%, Approved); spinal cord: 65.6934% (minimum 99%, Missing); spleen: 75.3138% (minimum 90%, Approved); stomach: 74.0741% (minimum 97%, Missing); thymus: 71.1462% (minimum 95%, Missing); thyroid gland: 73.1707% (minimum 90%, Approved); tongue: 77.2532% (minimum 97%, Missing); urinary bladder: 58.6319% (minimum 97%, Missing)",0,1,partial,10.1,12.7,7.6,"urinary bladder: 12.7 nTPM (protected, limit 2); smooth muscle: 10.1 nTPM (vital, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); colon: 7.9 nTPM (protected, limit 2); heart muscle: 7.9 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 4); thymus: 7.3 nTPM (manageable, limit 5); skin: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 4); salivary gland: 6.9 nTPM (protected, limit 2); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 4); retina: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 2); adrenal gland: 6.1 nTPM (vital, limit 2); hypothalamus: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 2); cerebellum: 3.9 nTPM (vital, limit 2); pancreas: 3.7 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000196605,ZNF846,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.238538,-0.383681,-0.339431
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,3.5,0.9,0.6,"liver: 3.5 nTPM (vital, limit 2); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196632,WNK3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 82.7338% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.2698% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.2698% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.4959% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.1473% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.0413% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.2906% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.2623% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.7419% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.7863% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.7419% (minimum 99%, Baseline (adaptation disabled)); liver: 76.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 97.4576% (minimum 99%, Baseline (adaptation disabled)); midbrain: 92.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.4576% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.7419% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.7338% (minimum 99%, Baseline (adaptation disabled)); retina: 78.2313% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2906% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.8333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.2623% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.0413% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.8333% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,3.5,0.9,0.6,"liver: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196632,WNK3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.000413223,-0.0425806,-0.223333
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 82.7338% (minimum 98%, Approved); amygdala: 91.2698% (minimum 99%, Missing); basal ganglia: 91.2698% (minimum 99%, Missing); cerebellum: 93.4959% (minimum 98%, Approved); cerebral cortex: 89.1473% (minimum 98%, Approved); choroid plexus: 95.0413% (minimum 99%, Missing); heart muscle: 94.2623% (minimum 98%, Approved); hippocampal formation: 92.7419% (minimum 99%, Missing); hypothalamus: 87.7863% (minimum 99%, Missing); kidney: 92.7419% (minimum 98%, Approved); liver: 76.6667% (minimum 98%, Approved); lung: 97.4576% (minimum 98%, Approved); midbrain: 92.0000% (minimum 99%, Missing); pancreas: 97.4576% (minimum 98%, Approved); parathyroid gland: 92.7419% (minimum 95%, Approved); pituitary gland: 82.7338% (minimum 99%, Missing); retina: 78.2313% (minimum 99%, Missing); smooth muscle: 95.8333% (minimum 98%, Approved); spinal cord: 94.2623% (minimum 99%, Missing)",0,1,partial,3.5,0.9,0.6,"liver: 3.5 nTPM (vital, limit 2); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196632,WNK3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0413793,-0.0225806,-0.213333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,5.1,4.9,7.9,"retina: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 3); choroid plexus: 4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 3); rectum: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196659,IFT70B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 86.2069% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.9565% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.4956% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.4701% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.5926% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.2381% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 71.4286% (minimum 99%, Baseline (adaptation disabled)); colon: 75.7576% (minimum 97%, Baseline (adaptation disabled)); duodenum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.0336% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.2069% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.4956% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.4956% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.0272% (minimum 99%, Baseline (adaptation disabled)); liver: 80.6452% (minimum 99%, Baseline (adaptation disabled)); lung: 76.3359% (minimum 99%, Baseline (adaptation disabled)); lymph node: 82.6446% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.0901% (minimum 99%, Baseline (adaptation disabled)); pancreas: 81.3008% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 67.1141% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 86.2069% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.5194% (minimum 97%, Baseline (adaptation disabled)); retina: 66.2252% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.0741% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); skin: 80.6452% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.1250% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.6452% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.2857% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.9672% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.4638% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.7576% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.8659% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.1538% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 84.7458% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,5.1,4.9,7.9,"thyroid gland: 7.9 nTPM (manageable, limit 5); retina: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.9 nTPM (protected, limit 2); kidney: 4.7 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196659,IFT70B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.391341,-0.298859,-0.327748
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 86.9565% (minimum 97%, Supported); amygdala: 88.4956% (minimum 99%, Missing); basal ganglia: 85.4701% (minimum 99%, Missing); bone marrow: 92.5926% (minimum 97%, Supported); cerebellum: 95.2381% (minimum 97%, Supported); cerebral cortex: 83.3333% (minimum 97%, Supported); choroid plexus: 71.4286% (minimum 99%, Missing); colon: 75.7576% (minimum 97%, Missing); duodenum: 80.0000% (minimum 99%, Missing); esophagus: 84.0336% (minimum 90%, Supported); heart muscle: 86.2069% (minimum 97%, Supported); hippocampal formation: 88.4956% (minimum 99%, Missing); hypothalamus: 88.4956% (minimum 99%, Missing); kidney: 68.0272% (minimum 97%, Supported); liver: 80.6452% (minimum 97%, Supported); lung: 76.3359% (minimum 97%, Supported); lymph node: 82.6446% (minimum 90%, Supported); midbrain: 90.0901% (minimum 99%, Missing); pancreas: 81.3008% (minimum 97%, Supported); parathyroid gland: 67.1141% (minimum 90%, Supported); pituitary gland: 86.2069% (minimum 99%, Missing); rectum: 77.5194% (minimum 97%, Missing); retina: 66.2252% (minimum 99%, Missing); salivary gland: 74.0741% (minimum 90%, Supported); skeletal muscle: 96.1538% (minimum 97%, Supported); small intestine: 78.1250% (minimum 99%, Missing); smooth muscle: 80.6452% (minimum 97%, Supported); spinal cord: 89.2857% (minimum 99%, Missing); stomach: 72.4638% (minimum 90%, Supported); thymus: 75.7576% (minimum 95%, Missing); thyroid gland: 55.8659% (minimum 80%, Supported); tongue: 96.1538% (minimum 97%, Missing); urinary bladder: 84.7458% (minimum 90%, Supported)",0,8,partial,5.1,4.9,7.9,"retina: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 3); choroid plexus: 4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 3); rectum: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196659,IFT70B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.241341,-0.228859,-0.327748
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,24,5.7,5.7,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 2); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); colon: 5.5 nTPM (protected, limit 2); skin: 5.3 nTPM (manageable, limit 5); urinary bladder: 4.8 nTPM (protected, limit 2); adrenal gland: 4.8 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196689,TRPV1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.4615% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.3469% (minimum 99%, Baseline (adaptation disabled)); amygdala: 61.4907% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.4907% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.8257% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.2314% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.7362% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.6106% (minimum 99%, Baseline (adaptation disabled)); colon: 64.2857% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.2353% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.5725% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.5581% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.9286% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.8750% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.6180% (minimum 99%, Baseline (adaptation disabled)); liver: 29.2035% (minimum 99%, Baseline (adaptation disabled)); lung: 76.1538% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.1475% (minimum 97%, Baseline (adaptation disabled)); midbrain: 58.9286% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.5714% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.4615% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.1475% (minimum 97%, Baseline (adaptation disabled)); retina: 44.1964% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.2128% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.1111% (minimum 99%, Baseline (adaptation disabled)); skin: 65.1316% (minimum 95%, Baseline (adaptation disabled)); small intestine: 54.0984% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.0870% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.6386% (minimum 99%, Baseline (adaptation disabled)); spleen: 70.2128% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.4615% (minimum 97%, Baseline (adaptation disabled)); thymus: 83.8983% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.7500% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.0870% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.3469% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,24,5.7,5.7,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 2); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); colon: 5.5 nTPM (protected, limit 2); skin: 5.3 nTPM (manageable, limit 5); urinary bladder: 4.8 nTPM (protected, limit 2); adrenal gland: 4.8 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196689,TRPV1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.315385,-0.335385,-0.697965
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.4615% (minimum 95%, Missing); adrenal gland: 67.3469% (minimum 99%, Missing); amygdala: 61.4907% (minimum 99%, Missing); basal ganglia: 61.4907% (minimum 99%, Missing); bone marrow: 90.8257% (minimum 99%, Missing); cerebellum: 43.2314% (minimum 99%, Missing); cerebral cortex: 60.7362% (minimum 99%, Missing); choroid plexus: 87.6106% (minimum 99%, Missing); colon: 64.2857% (minimum 97%, Missing); duodenum: 58.2353% (minimum 99%, Missing); esophagus: 75.5725% (minimum 97%, Missing); heart muscle: 57.5581% (minimum 99%, Missing); hippocampal formation: 58.9286% (minimum 99%, Missing); hypothalamus: 61.8750% (minimum 99%, Missing); kidney: 55.6180% (minimum 99%, Missing); liver: 29.2035% (minimum 99%, Missing); lung: 76.1538% (minimum 99%, Missing); lymph node: 81.1475% (minimum 97%, Missing); midbrain: 58.9286% (minimum 99%, Missing); pancreas: 56.5714% (minimum 99%, Missing); parathyroid gland: 90.0000% (minimum 97%, Missing); pituitary gland: 63.4615% (minimum 99%, Missing); rectum: 81.1475% (minimum 97%, Missing); retina: 44.1964% (minimum 99%, Missing); salivary gland: 70.2128% (minimum 97%, Missing); skeletal muscle: 61.1111% (minimum 99%, Missing); skin: 65.1316% (minimum 95%, Missing); small intestine: 54.0984% (minimum 99%, Missing); smooth muscle: 86.0870% (minimum 99%, Missing); spinal cord: 59.6386% (minimum 99%, Missing); spleen: 70.2128% (minimum 95%, Missing); stomach: 63.4615% (minimum 97%, Missing); thymus: 83.8983% (minimum 95%, Missing); thyroid gland: 68.7500% (minimum 95%, Missing); tongue: 86.0870% (minimum 97%, Missing); urinary bladder: 67.3469% (minimum 97%, Missing)",0,80,unavailable,24,5.7,5.7,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 2); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); colon: 5.5 nTPM (protected, limit 2); skin: 5.3 nTPM (manageable, limit 5); urinary bladder: 4.8 nTPM (protected, limit 2); adrenal gland: 4.8 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 2); esophagus: 3.2 nTPM (protected, limit 2); lung: 3.1 nTPM (vital, limit 1); rectum: 2.3 nTPM (protected, limit 2); lymph node: 2.3 nTPM (protected, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196689,TRPV1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.315385,-0.335385,-0.697965
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,26.1,18.3,20.2,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (manageable, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 2); thymus: 16.6 nTPM (manageable, limit 5); kidney: 13.7 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 2); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 2); salivary gland: 11.3 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 2); colon: 9.9 nTPM (protected, limit 2); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 2); choroid plexus: 9.5 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); small intestine: 8.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000196712,NF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.8099% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.7947% (minimum 99%, Baseline (adaptation disabled)); amygdala: 61.7886% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.2903% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.2834% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.8736% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 44.3149% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 61.5385% (minimum 99%, Baseline (adaptation disabled)); colon: 60.5578% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.5172% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.3704% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.8736% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.7886% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.2951% (minimum 99%, Baseline (adaptation disabled)); kidney: 52.5952% (minimum 99%, Baseline (adaptation disabled)); liver: 55.8824% (minimum 99%, Baseline (adaptation disabled)); lung: 65.2361% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.2903% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.0408% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.4615% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 45.3731% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.0791% (minimum 97%, Baseline (adaptation disabled)); retina: 36.8039% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.3585% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.2951% (minimum 99%, Baseline (adaptation disabled)); skin: 58.2375% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.5983% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.0442% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 58.9147% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.1350% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.5514% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.7987% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 42.9379% (minimum 95%, Baseline (adaptation disabled)); tongue: 55.2727% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 56.7164% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,26.1,18.3,20.2,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (manageable, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 2); thymus: 16.6 nTPM (manageable, limit 5); kidney: 13.7 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 2); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 2); salivary gland: 11.3 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 2); colon: 9.9 nTPM (protected, limit 2); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 2); choroid plexus: 9.5 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); small intestine: 8.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000196712,NF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.520621,-0.516269,-0.621961
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.8099% (minimum 95%, Uncertain); adrenal gland: 57.7947% (minimum 99%, Missing); amygdala: 61.7886% (minimum 99%, Missing); basal ganglia: 61.2903% (minimum 99%, Missing); bone marrow: 81.2834% (minimum 99%, Missing); cerebellum: 54.8736% (minimum 99%, Missing); cerebral cortex: 44.3149% (minimum 99%, Missing); choroid plexus: 61.5385% (minimum 99%, Missing); colon: 60.5578% (minimum 97%, Missing); duodenum: 65.5172% (minimum 99%, Missing); esophagus: 70.3704% (minimum 97%, Missing); heart muscle: 54.8736% (minimum 99%, Missing); hippocampal formation: 61.7886% (minimum 99%, Missing); hypothalamus: 62.2951% (minimum 99%, Missing); kidney: 52.5952% (minimum 99%, Missing); liver: 55.8824% (minimum 99%, Missing); lung: 65.2361% (minimum 99%, Missing); lymph node: 61.2903% (minimum 97%, Missing); midbrain: 62.0408% (minimum 99%, Missing); pancreas: 58.4615% (minimum 99%, Missing); parathyroid gland: 45.3731% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); rectum: 60.0791% (minimum 97%, Missing); retina: 36.8039% (minimum 99%, Missing); salivary gland: 57.3585% (minimum 97%, Missing); skeletal muscle: 62.2951% (minimum 99%, Missing); skin: 58.2375% (minimum 95%, Missing); small intestine: 63.5983% (minimum 99%, Missing); smooth muscle: 61.0442% (minimum 99%, Missing); spinal cord: 58.9147% (minimum 99%, Missing); spleen: 64.1350% (minimum 95%, Missing); stomach: 62.5514% (minimum 97%, Missing); thymus: 47.7987% (minimum 95%, Missing); thyroid gland: 42.9379% (minimum 95%, Missing); tongue: 55.2727% (minimum 97%, Missing); urinary bladder: 56.7164% (minimum 97%, Missing)",0,6,partial,26.1,18.3,20.2,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (manageable, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 2); thymus: 16.6 nTPM (manageable, limit 5); kidney: 13.7 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 2); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 2); salivary gland: 11.3 nTPM (protected, limit 2); adrenal gland: 11.1 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 2); colon: 9.9 nTPM (protected, limit 2); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 2); choroid plexus: 9.5 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 2); adipose tissue: 9 nTPM (manageable, limit 5); small intestine: 8.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 2); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000196712,NF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.520621,-0.516269,-0.621961
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,5,1.6,0.2,"pancreas: 5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells,ENSG00000196748,CLPSL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0,3,partial,5,1.6,0.2,"pancreas: 5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells,ENSG00000196748,CLPSL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0496143,0.0269231,0.000447077
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0,3,partial,5,1.6,0.2,"pancreas: 5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells,ENSG00000196748,CLPSL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0498071,0.0269231,0.00922899
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000196772,OR14A16,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 50.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000196772,OR14A16,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.49
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 50.0000% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000196772,OR14A16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.49
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,False,,9,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000196832,OR11G2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000196832,OR11G2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000196832,OR11G2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000196834,POTEI,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.9697% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.9697% (minimum 99%, Baseline (adaptation disabled)); retina: 96.9697% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.1176% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000196834,POTEI,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.019697,-0.0288235,-0.101111
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 88.8889% (minimum 99%, Missing); pancreas: 96.9697% (minimum 99%, Missing); pituitary gland: 96.9697% (minimum 99%, Missing); retina: 96.9697% (minimum 99%, Missing); stomach: 94.1176% (minimum 97%, Missing)",0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000196834,POTEI,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.019697,-0.0288235,-0.101111
True,compatible,,True,True,False,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000196844,PATE2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
True,compatible,,True,True,True,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000196844,PATE2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,0.03,0.00909112
True,compatible,,True,True,True,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000196844,PATE2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,0.03,0.00909112
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,4,partial,0.4,0.5,0.5,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; tonsil,ENSG00000196860,TOMM20L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 97.2477% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.2477% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.1481% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.3636% (minimum 99%, Baseline (adaptation disabled)); liver: 98.1481% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.4955% (minimum 97%, Baseline (adaptation disabled)); retina: 96.3636% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.2477% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.3636% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,0.4,0.5,0.5,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; tonsil,ENSG00000196860,TOMM20L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00495495,-0.015045,-0.0263636
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 97.2477% (minimum 99%, Missing); retina: 96.3636% (minimum 99%, Missing); small intestine: 97.2477% (minimum 99%, Missing)",0,4,partial,0.4,0.5,0.5,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; tonsil,ENSG00000196860,TOMM20L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.0263636
True,compatible,,True,True,False,,0,80,unavailable,1,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000196862,RGPD4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.7368% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.2973% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.7368% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.7368% (minimum 99%, Baseline (adaptation disabled)); duodenum: 94.7368% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.2973% (minimum 99%, Baseline (adaptation disabled)); liver: 97.2973% (minimum 99%, Baseline (adaptation disabled)); lung: 97.2973% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.7368% (minimum 97%, Baseline (adaptation disabled)); retina: 78.2609% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 94.7368% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.7368% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.7368% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.3077% (minimum 97%, Baseline (adaptation disabled)); thymus: 92.3077% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000196862,RGPD4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,-0.0269231,-0.0469231,-0.207391
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 94.7368% (minimum 99%, Missing); bone marrow: 97.2973% (minimum 99%, Missing); cerebral cortex: 94.7368% (minimum 99%, Missing); choroid plexus: 94.7368% (minimum 99%, Missing); duodenum: 94.7368% (minimum 99%, Missing); kidney: 97.2973% (minimum 99%, Missing); liver: 97.2973% (minimum 99%, Missing); lung: 97.2973% (minimum 99%, Missing); lymph node: 94.7368% (minimum 97%, Missing); retina: 78.2609% (minimum 99%, Missing); skeletal muscle: 94.7368% (minimum 99%, Missing); small intestine: 94.7368% (minimum 99%, Missing); spleen: 94.7368% (minimum 95%, Missing); stomach: 92.3077% (minimum 97%, Missing); thymus: 92.3077% (minimum 95%, Missing)",0,80,unavailable,1,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000196862,RGPD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,-0.0269231,-0.0469231,-0.207391
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.6,0,,,0,not_established,not_triggered,,,ENSG00000196900,SPMIP10,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0.6,0,,,0,not_established,not_triggered,,,ENSG00000196900,SPMIP10,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.00424893,0.00126638
True,compatible,,True,True,True,,0,80,unavailable,0.2,0.6,0,,,0,not_established,not_triggered,,,ENSG00000196900,SPMIP10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.00424893,0.00126638
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,19.5,12.4,11.1,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 2); thyroid gland: 11.1 nTPM (manageable, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); cerebellum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 2); smooth muscle: 6.6 nTPM (vital, limit 6); adrenal gland: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); salivary gland: 4.2 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in granular layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000196911,KPNA5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 90.6459% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.9050% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.1350% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.1350% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.0442% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.6154% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.6477% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.3162% (minimum 99%, Baseline (adaptation disabled)); colon: 92.7107% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.5632% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.6459% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.2439% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.1350% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.1350% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.4783% (minimum 99%, Baseline (adaptation disabled)); liver: 93.9954% (minimum 99%, Baseline (adaptation disabled)); lung: 87.3391% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.2375% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.9224% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.6512% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.3249% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.0442% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 67.6080% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.6459% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.2172% (minimum 99%, Baseline (adaptation disabled)); skin: 90.8482% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.7107% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.0465% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.9224% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.7917% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.9145% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.5714% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.6478% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.6476% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,19.5,12.4,11.1,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 2); thyroid gland: 11.1 nTPM (manageable, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 9.4 nTPM (protected, limit 2); cerebellum: 7.4 nTPM (vital, limit 1); spleen: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 2); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); bone marrow: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); salivary gland: 4.2 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in granular layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000196911,KPNA5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.164286,-0.203522,-0.31392
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.9050% (minimum 99%, Missing); amygdala: 93.1350% (minimum 99%, Missing); basal ganglia: 93.1350% (minimum 99%, Missing); bone marrow: 90.0442% (minimum 99%, Missing); cerebellum: 84.6154% (minimum 99%, Missing); cerebral cortex: 79.6477% (minimum 99%, Missing); choroid plexus: 95.3162% (minimum 99%, Missing); colon: 92.7107% (minimum 97%, Missing); duodenum: 93.5632% (minimum 99%, Missing); esophagus: 90.6459% (minimum 97%, Missing); heart muscle: 90.2439% (minimum 99%, Missing); hippocampal formation: 93.1350% (minimum 99%, Missing); hypothalamus: 93.1350% (minimum 99%, Missing); kidney: 88.4783% (minimum 99%, Missing); liver: 93.9954% (minimum 95%, Enhanced); lung: 87.3391% (minimum 95%, Enhanced); midbrain: 92.9224% (minimum 99%, Missing); pancreas: 94.6512% (minimum 95%, Enhanced); parathyroid gland: 85.3249% (minimum 97%, Missing); pituitary gland: 90.0442% (minimum 99%, Missing); rectum: 92.5000% (minimum 97%, Missing); retina: 67.6080% (minimum 99%, Missing); salivary gland: 90.6459% (minimum 97%, Missing); skeletal muscle: 76.2172% (minimum 99%, Missing); skin: 90.8482% (minimum 95%, Missing); small intestine: 92.7107% (minimum 99%, Missing); smooth muscle: 86.0465% (minimum 95%, Enhanced); spinal cord: 92.9224% (minimum 99%, Missing); stomach: 91.6667% (minimum 97%, Missing); thymus: 80.9145% (minimum 95%, Missing); thyroid gland: 78.5714% (minimum 95%, Missing); tongue: 76.6478% (minimum 97%, Missing)",0,8,partial,19.5,12.4,11.1,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 2); thyroid gland: 11.1 nTPM (manageable, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); cerebellum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 2); smooth muscle: 6.6 nTPM (vital, limit 6); adrenal gland: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); salivary gland: 4.2 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); rectum: 3.3 nTPM (protected, limit 2); colon: 3.2 nTPM (protected, limit 2); small intestine: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in granular layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000196911,KPNA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.164286,-0.203522,-0.31392
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.9,3.6,3,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); hypothalamus: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196912,ANKRD36B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 56.7164% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.0769% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.3175% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 33.6283% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 29.9213% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.3175% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.4762% (minimum 99%, Baseline (adaptation disabled)); colon: 60.3175% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.6087% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.0769% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 59.3750% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.4068% (minimum 99%, Baseline (adaptation disabled)); kidney: 71.6981% (minimum 99%, Baseline (adaptation disabled)); liver: 82.6087% (minimum 99%, Baseline (adaptation disabled)); lung: 64.4068% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.4068% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 48.1013% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.6087% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.2903% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.5172% (minimum 97%, Baseline (adaptation disabled)); retina: 55.8824% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.3514% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 84.4444% (minimum 99%, Baseline (adaptation disabled)); skin: 55.8824% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.2951% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 55.8824% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.4068% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.2951% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.4068% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.9,3.6,3,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); hypothalamus: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196912,ANKRD36B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.391176,-0.456486,-0.690787
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 56.7164% (minimum 95%, Missing); adrenal gland: 73.0769% (minimum 99%, Missing); amygdala: 63.3333% (minimum 99%, Missing); basal ganglia: 60.3175% (minimum 99%, Missing); bone marrow: 33.6283% (minimum 99%, Missing); cerebellum: 29.9213% (minimum 99%, Missing); cerebral cortex: 60.3175% (minimum 99%, Missing); choroid plexus: 90.4762% (minimum 99%, Missing); colon: 60.3175% (minimum 97%, Missing); duodenum: 82.6087% (minimum 99%, Missing); esophagus: 73.0769% (minimum 97%, Missing); heart muscle: 66.6667% (minimum 99%, Missing); hippocampal formation: 59.3750% (minimum 99%, Missing); hypothalamus: 64.4068% (minimum 99%, Missing); kidney: 71.6981% (minimum 99%, Missing); liver: 82.6087% (minimum 99%, Missing); lung: 64.4068% (minimum 99%, Missing); lymph node: 64.4068% (minimum 97%, Missing); midbrain: 63.3333% (minimum 99%, Missing); pancreas: 48.1013% (minimum 99%, Missing); parathyroid gland: 82.6087% (minimum 97%, Missing); pituitary gland: 61.2903% (minimum 99%, Missing); rectum: 65.5172% (minimum 97%, Missing); retina: 55.8824% (minimum 99%, Missing); salivary gland: 51.3514% (minimum 97%, Missing); skeletal muscle: 84.4444% (minimum 99%, Missing); skin: 55.8824% (minimum 95%, Missing); small intestine: 62.2951% (minimum 99%, Missing); smooth muscle: 76.0000% (minimum 99%, Missing); spinal cord: 55.8824% (minimum 99%, Missing); spleen: 64.4068% (minimum 95%, Missing); stomach: 63.3333% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 62.2951% (minimum 95%, Missing); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 64.4068% (minimum 97%, Missing)",0,80,unavailable,8.9,3.6,3,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2); retina: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); urinary bladder: 2.1 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); hypothalamus: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000196912,ANKRD36B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.391176,-0.456486,-0.690787
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.4,0.6,1.2,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000196946,ZNF705A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.1852% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.1622% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.3103% (minimum 99%, Baseline (adaptation disabled)); colon: 88.4615% (minimum 97%, Baseline (adaptation disabled)); esophagus: 88.4615% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.4615% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.4615% (minimum 99%, Baseline (adaptation disabled)); lung: 88.4615% (minimum 99%, Baseline (adaptation disabled)); lymph node: 79.3103% (minimum 97%, Baseline (adaptation disabled)); parathyroid gland: 79.3103% (minimum 97%, Baseline (adaptation disabled)); rectum: 88.4615% (minimum 97%, Baseline (adaptation disabled)); retina: 85.1852% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.1852% (minimum 97%, Baseline (adaptation disabled)); skin: 92.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.8333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 74.1935% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.8333% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.1852% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.7143% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 85.1852% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.4,0.6,1.2,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000196946,ZNF705A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.292857,-0.176897,-0.368378
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 85.1852% (minimum 99%, Missing); cerebral cortex: 62.1622% (minimum 99%, Missing); choroid plexus: 79.3103% (minimum 99%, Missing); colon: 88.4615% (minimum 97%, Missing); esophagus: 88.4615% (minimum 97%, Missing); heart muscle: 88.4615% (minimum 99%, Missing); kidney: 88.4615% (minimum 99%, Missing); lung: 88.4615% (minimum 99%, Missing); lymph node: 79.3103% (minimum 97%, Missing); parathyroid gland: 79.3103% (minimum 97%, Missing); rectum: 88.4615% (minimum 97%, Missing); retina: 85.1852% (minimum 99%, Missing); salivary gland: 85.1852% (minimum 97%, Missing); skin: 92.0000% (minimum 95%, Missing); small intestine: 95.8333% (minimum 99%, Missing); smooth muscle: 74.1935% (minimum 99%, Missing); stomach: 95.8333% (minimum 97%, Missing); thymus: 85.1852% (minimum 95%, Missing); thyroid gland: 65.7143% (minimum 95%, Missing); urinary bladder: 85.1852% (minimum 97%, Missing)",0,80,unavailable,1.4,0.6,1.2,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000196946,ZNF705A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.292857,-0.176897,-0.368378
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,6.7,4.6,5.2,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4.6 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 2); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197054,ZNF763,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0526% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.9091% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.3247% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.3590% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.3158% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.2353% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.3247% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 65.1685% (minimum 99%, Baseline (adaptation disabled)); colon: 63.7363% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.5000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.3247% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.4167% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.4177% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.4348% (minimum 99%, Baseline (adaptation disabled)); liver: 70.7317% (minimum 99%, Baseline (adaptation disabled)); lung: 67.4419% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.3656% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.6049% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.8627% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.7692% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.4419% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 46.4000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.4444% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 75.3247% (minimum 99%, Baseline (adaptation disabled)); skin: 68.2353% (minimum 95%, Baseline (adaptation disabled)); small intestine: 58.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.4177% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.3590% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.7273% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.0435% (minimum 97%, Baseline (adaptation disabled)); thymus: 58.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.2381% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.4521% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 63.0435% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,6.7,4.6,5.2,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4.6 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197054,ZNF763,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.422727,-0.412308,-0.526
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0526% (minimum 95%, Missing); adrenal gland: 65.9091% (minimum 99%, Missing); amygdala: 75.3247% (minimum 99%, Missing); basal ganglia: 74.3590% (minimum 99%, Missing); bone marrow: 76.3158% (minimum 98%, Approved); cerebellum: 68.2353% (minimum 98%, Approved); cerebral cortex: 75.3247% (minimum 99%, Missing); choroid plexus: 65.1685% (minimum 99%, Missing); colon: 63.7363% (minimum 97%, Missing); duodenum: 72.5000% (minimum 99%, Missing); esophagus: 75.3247% (minimum 97%, Missing); heart muscle: 60.4167% (minimum 99%, Missing); hippocampal formation: 73.4177% (minimum 99%, Missing); hypothalamus: 77.3333% (minimum 99%, Missing); kidney: 50.4348% (minimum 99%, Missing); liver: 70.7317% (minimum 99%, Missing); lung: 67.4419% (minimum 99%, Missing); lymph node: 62.3656% (minimum 97%, Missing); midbrain: 71.6049% (minimum 99%, Missing); pancreas: 56.8627% (minimum 99%, Missing); parathyroid gland: 55.7692% (minimum 97%, Missing); pituitary gland: 67.4419% (minimum 99%, Missing); rectum: 66.6667% (minimum 97%, Missing); retina: 46.4000% (minimum 99%, Missing); salivary gland: 64.4444% (minimum 97%, Missing); skeletal muscle: 75.3247% (minimum 98%, Approved); skin: 68.2353% (minimum 95%, Missing); small intestine: 58.0000% (minimum 99%, Missing); smooth muscle: 73.4177% (minimum 99%, Missing); spinal cord: 74.3590% (minimum 99%, Missing); spleen: 52.7273% (minimum 95%, Missing); stomach: 63.0435% (minimum 97%, Missing); thymus: 58.0000% (minimum 95%, Missing); thyroid gland: 55.2381% (minimum 95%, Missing); tongue: 79.4521% (minimum 97%, Missing); urinary bladder: 63.0435% (minimum 97%, Missing)",0,5,partial,6.7,4.6,5.2,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4.6 nTPM (protected, limit 2); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 2); stomach: 3.4 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); colon: 3.3 nTPM (protected, limit 2); salivary gland: 3.2 nTPM (protected, limit 2); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); rectum: 2.9 nTPM (protected, limit 2); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 2); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197054,ZNF763,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.422727,-0.412308,-0.526
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,6,partial,0,0.6,56.3,"skin: 56.3 nTPM (manageable, limit 30)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; spleen,ENSG00000197079,KRT35,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 5.0000% (minimum 95%, Baseline (adaptation disabled)); salivary gland: 14.2857% (minimum 97%, Baseline (adaptation disabled)); skin: 0.1773% (minimum 95%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,0,0.6,56.3,"skin: 56.3 nTPM (manageable, limit 5)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; spleen,ENSG00000197079,KRT35,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.948227,-0.827143,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 5.0000% (minimum 60%, Enhanced); salivary gland: 14.2857% (minimum 80%, Enhanced); skin: 0.1773% (minimum 60%, Enhanced); spleen: 50.0000% (minimum 60%, Enhanced)",0,6,partial,0,0.6,56.3,"skin: 56.3 nTPM (manageable, limit 30)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; spleen,ENSG00000197079,KRT35,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.598227,-0.657143,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197123,ZNF679,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197123,ZNF679,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197123,ZNF679,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.1,2.5,2.2,"bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197134,ZNF257,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.8710% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.8710% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.8571% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.6552% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.8060% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.8571% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.4706% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.8710% (minimum 99%, Baseline (adaptation disabled)); colon: 78.7879% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.6552% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.2500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.8571% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.8571% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.2500% (minimum 99%, Baseline (adaptation disabled)); liver: 86.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 76.4706% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.9804% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.3191% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 72.2222% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.8571% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.8710% (minimum 97%, Baseline (adaptation disabled)); retina: 78.7879% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.6552% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); skin: 74.2857% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.4706% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.2500% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.9048% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.9048% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.1667% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 72.2222% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.1,2.5,2.2,"bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197134,ZNF257,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.408333,-0.460196,-0.60194
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.8710% (minimum 95%, Missing); adrenal gland: 83.8710% (minimum 99%, Missing); amygdala: 92.8571% (minimum 99%, Missing); basal ganglia: 89.6552% (minimum 99%, Missing); bone marrow: 38.8060% (minimum 99%, Missing); cerebellum: 92.8571% (minimum 99%, Missing); cerebral cortex: 76.4706% (minimum 99%, Missing); choroid plexus: 83.8710% (minimum 99%, Missing); colon: 78.7879% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); esophagus: 89.6552% (minimum 97%, Missing); heart muscle: 81.2500% (minimum 99%, Missing); hippocampal formation: 92.8571% (minimum 99%, Missing); hypothalamus: 92.8571% (minimum 99%, Missing); kidney: 81.2500% (minimum 99%, Missing); liver: 86.6667% (minimum 99%, Missing); lung: 76.4706% (minimum 99%, Missing); lymph node: 50.9804% (minimum 97%, Missing); midbrain: 86.6667% (minimum 99%, Missing); pancreas: 55.3191% (minimum 99%, Missing); parathyroid gland: 72.2222% (minimum 97%, Missing); pituitary gland: 92.8571% (minimum 99%, Missing); rectum: 83.8710% (minimum 97%, Missing); retina: 78.7879% (minimum 99%, Missing); salivary gland: 89.6552% (minimum 97%, Missing); skeletal muscle: 92.8571% (minimum 99%, Missing); skin: 74.2857% (minimum 95%, Missing); small intestine: 86.6667% (minimum 99%, Missing); smooth muscle: 76.4706% (minimum 99%, Missing); spinal cord: 81.2500% (minimum 99%, Missing); spleen: 61.9048% (minimum 95%, Missing); stomach: 65.0000% (minimum 97%, Missing); thymus: 61.9048% (minimum 95%, Missing); thyroid gland: 54.1667% (minimum 95%, Missing); urinary bladder: 72.2222% (minimum 97%, Missing)",0,80,unavailable,4.1,2.5,2.2,"bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197134,ZNF257,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.408333,-0.460196,-0.60194
True,compatible,,True,True,False,,0,6,partial,1.7,0.5,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000197140,ADAM32,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.7273% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.1550% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5185% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.5185% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1550% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.4359% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.4359% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.7941% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.7273% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8848% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.1550% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.9929% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.5185% (minimum 99%, Baseline (adaptation disabled)); retina: 96.7273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5185% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,1.7,0.5,0.9,"pancreas: 1.7 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000197140,ADAM32,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0172727,0.0115498,-0.0500707
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.1550% (minimum 99%, Missing); basal ganglia: 98.5185% (minimum 99%, Missing); hippocampal formation: 97.7941% (minimum 99%, Missing); hypothalamus: 96.7273% (minimum 99%, Missing); midbrain: 98.1550% (minimum 99%, Missing); pancreas: 93.9929% (minimum 95%, Enhanced); pituitary gland: 98.5185% (minimum 99%, Missing); retina: 96.7273% (minimum 99%, Missing); spinal cord: 98.5185% (minimum 99%, Missing)",0,6,partial,1.7,0.5,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000197140,ADAM32,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0262547,-0.0227273
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,False,,0,7,partial,1.2,1,1.1,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197153,H3C12,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"amygdala: 50.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 20.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); esophagus: 75.0000% (minimum 97%, Baseline (adaptation disabled)); liver: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 23.0769% (minimum 97%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 42.8571% (minimum 95%, Baseline (adaptation disabled)); thymus: 21.4286% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,1.2,1,1.1,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197153,H3C12,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.735714,-0.739231,-0.79
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"amygdala: 50.0000% (minimum 99%, Missing); bone marrow: 20.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); esophagus: 75.0000% (minimum 97%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 23.0769% (minimum 97%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); spleen: 42.8571% (minimum 95%, Missing); thymus: 21.4286% (minimum 95%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,7,partial,1.2,1,1.1,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197153,H3C12,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.735714,-0.739231,-0.79
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000197172,MAGEA6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.5714% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000197172,MAGEA6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.021831,0.03,-0.00428571
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.5714% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000197172,MAGEA6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.021831,0.03,-0.00428571
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.8,1.4,1.1,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197181,PIWIL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2394% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.5524% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.8750% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.5866% (minimum 99%, Baseline (adaptation disabled)); colon: 96.8750% (minimum 97%, Baseline (adaptation disabled)); duodenum: 82.7893% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2394% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.8947% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.5398% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.9362% (minimum 99%, Baseline (adaptation disabled)); liver: 96.5398% (minimum 99%, Baseline (adaptation disabled)); lung: 98.9362% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.5524% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.3841% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.8980% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.8750% (minimum 97%, Baseline (adaptation disabled)); retina: 96.8750% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 92.0792% (minimum 99%, Baseline (adaptation disabled)); small intestine: 93.9394% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.2394% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2394% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.2218% (minimum 97%, Baseline (adaptation disabled)); tongue: 96.5398% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.8,1.4,1.1,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197181,PIWIL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.012069,-0.0177816,-0.162107
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.2394% (minimum 99%, Missing); basal ganglia: 97.5524% (minimum 99%, Missing); cerebellum: 96.8750% (minimum 99%, Missing); cerebral cortex: 98.5866% (minimum 99%, Missing); colon: 96.8750% (minimum 97%, Missing); duodenum: 82.7893% (minimum 99%, Missing); heart muscle: 98.2394% (minimum 99%, Missing); hippocampal formation: 97.8947% (minimum 99%, Missing); hypothalamus: 96.5398% (minimum 99%, Missing); kidney: 98.9362% (minimum 99%, Missing); liver: 96.5398% (minimum 99%, Missing); lung: 98.9362% (minimum 99%, Missing); midbrain: 97.5524% (minimum 99%, Missing); pancreas: 92.3841% (minimum 99%, Missing); pituitary gland: 94.8980% (minimum 99%, Missing); rectum: 96.8750% (minimum 97%, Missing); retina: 96.8750% (minimum 99%, Missing); skeletal muscle: 92.0792% (minimum 99%, Missing); small intestine: 93.9394% (minimum 99%, Missing); smooth muscle: 98.2394% (minimum 99%, Missing); spinal cord: 98.2394% (minimum 99%, Missing); stomach: 95.2218% (minimum 97%, Missing); tongue: 96.5398% (minimum 97%, Missing)",0,80,unavailable,5.8,1.4,1.1,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197181,PIWIL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,0.012069,-0.0177816,-0.162107
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,48,16.6,15.4,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 6); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 2); thymus: 15.4 nTPM (manageable, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 2); amygdala: 13 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); lung: 12.7 nTPM (vital, limit 1); spleen: 12.6 nTPM (manageable, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 2); basal ganglia: 9.3 nTPM (vital, limit 1); thyroid gland: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 2); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 6); lymph node: 8.1 nTPM (protected, limit 2); liver: 6.7 nTPM (vital, limit 6); smooth muscle: 6.3 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000197183,NOL4L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.2144% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.2685% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.7025% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.1497% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 67.1900% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 69.1438% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.6770% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.4663% (minimum 99%, Baseline (adaptation disabled)); colon: 72.0539% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.7068% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.6903% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.1667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.5645% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.1022% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.3521% (minimum 99%, Baseline (adaptation disabled)); liver: 86.4646% (minimum 99%, Baseline (adaptation disabled)); lung: 77.1171% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.0864% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.1022% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.6780% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.4596% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.4286% (minimum 97%, Baseline (adaptation disabled)); retina: 47.1366% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 81.8356% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.6140% (minimum 99%, Baseline (adaptation disabled)); skin: 92.8416% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.5897% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.1690% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.4016% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.2563% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.7025% (minimum 97%, Baseline (adaptation disabled)); thymus: 73.5395% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.1497% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.3964% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.1497% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,48,16.6,15.4,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 1); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 2); thymus: 15.4 nTPM (manageable, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 2); amygdala: 13 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); lung: 12.7 nTPM (vital, limit 1); spleen: 12.6 nTPM (manageable, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 2); thyroid gland: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 2); basal ganglia: 9.3 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 2); liver: 6.7 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 2); esophagus: 2.4 nTPM (protected, limit 2); skeletal muscle: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000197183,NOL4L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.214605,-0.249461,-0.518634
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.2144% (minimum 95%, Missing); adrenal gland: 83.2685% (minimum 95%, Enhanced); amygdala: 76.7025% (minimum 99%, Missing); basal ganglia: 82.1497% (minimum 99%, Missing); bone marrow: 67.1900% (minimum 95%, Enhanced); cerebellum: 69.1438% (minimum 99%, Missing); cerebral cortex: 77.6770% (minimum 99%, Missing); choroid plexus: 82.4663% (minimum 99%, Missing); colon: 72.0539% (minimum 97%, Missing); duodenum: 69.7068% (minimum 99%, Missing); esophagus: 94.6903% (minimum 97%, Missing); heart muscle: 89.1667% (minimum 95%, Enhanced); hippocampal formation: 74.5645% (minimum 99%, Missing); hypothalamus: 78.1022% (minimum 99%, Missing); kidney: 75.3521% (minimum 99%, Missing); liver: 86.4646% (minimum 95%, Enhanced); lung: 77.1171% (minimum 99%, Missing); lymph node: 84.0864% (minimum 97%, Missing); midbrain: 78.1022% (minimum 99%, Missing); pancreas: 80.0000% (minimum 99%, Missing); pituitary gland: 66.4596% (minimum 99%, Missing); rectum: 76.4286% (minimum 97%, Missing); retina: 47.1366% (minimum 99%, Missing); salivary gland: 81.8356% (minimum 97%, Missing); skin: 92.8416% (minimum 95%, Missing); small intestine: 68.5897% (minimum 99%, Missing); smooth muscle: 87.1690% (minimum 99%, Missing); spinal cord: 67.4016% (minimum 99%, Missing); spleen: 77.2563% (minimum 95%, Missing); stomach: 76.7025% (minimum 97%, Missing); thymus: 73.5395% (minimum 95%, Missing); thyroid gland: 82.1497% (minimum 95%, Missing); tongue: 96.3964% (minimum 97%, Missing); urinary bladder: 82.1497% (minimum 97%, Missing)",0,4,partial,48,16.6,15.4,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 6); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 2); thymus: 15.4 nTPM (manageable, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 2); amygdala: 13 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 2); lung: 12.7 nTPM (vital, limit 1); spleen: 12.6 nTPM (manageable, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 2); basal ganglia: 9.3 nTPM (vital, limit 1); thyroid gland: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 2); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 6); lymph node: 8.1 nTPM (protected, limit 2); liver: 6.7 nTPM (vital, limit 6); smooth muscle: 6.3 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2)",adipose tissue / adipocytes: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000197183,NOL4L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.214605,-0.249461,-0.518634
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,1,partial,0.3,0,0.1,,cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells,ENSG00000197213,ZSCAN5B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 89.4737% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.4444% (minimum 99%, Baseline (adaptation disabled)); skin: 94.4444% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,0.3,0,0.1,,cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells,ENSG00000197213,ZSCAN5B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.00555556,0.03,-0.14
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 89.4737% (minimum 99%, Missing); basal ganglia: 85.0000% (minimum 99%, Missing); cerebral cortex: 94.4444% (minimum 99%, Missing); skin: 94.4444% (minimum 95%, Missing)",0,1,partial,0.3,0,0.1,,cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells,ENSG00000197213,ZSCAN5B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.00555556,0.03,-0.14
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,13,partial,31.7,28.6,24.8,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 2); parathyroid gland: 26.2 nTPM (protected, limit 2); small intestine: 25.5 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); salivary gland: 21.4 nTPM (protected, limit 2); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 3); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 2); rectum: 19.6 nTPM (protected, limit 2); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 2); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 2); smooth muscle: 15.9 nTPM (vital, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 15); tongue: 15.3 nTPM (protected, limit 2); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (manageable, limit 5); thymus: 14.1 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 3); esophagus: 12.2 nTPM (protected, limit 6); skin: 12.1 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197217,ENTPD4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.1429% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.4868% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.1979% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.6833% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.9899% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.0616% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 49.1094% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.7820% (minimum 99%, Baseline (adaptation disabled)); colon: 50.2604% (minimum 97%, Baseline (adaptation disabled)); duodenum: 52.4457% (minimum 99%, Baseline (adaptation disabled)); esophagus: 61.2698% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 48.6146% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.6964% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.2027% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.0579% (minimum 99%, Baseline (adaptation disabled)); liver: 59.0214% (minimum 99%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 40.2923% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 48.1297% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 42.4176% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 52.0216% (minimum 99%, Baseline (adaptation disabled)); rectum: 49.6144% (minimum 97%, Baseline (adaptation disabled)); retina: 37.8431% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 47.4201% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 56.7647% (minimum 99%, Baseline (adaptation disabled)); skin: 61.4650% (minimum 95%, Baseline (adaptation disabled)); small intestine: 43.0804% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 54.8295% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.1196% (minimum 99%, Baseline (adaptation disabled)); spleen: 43.7642% (minimum 95%, Baseline (adaptation disabled)); stomach: 49.4872% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.7844% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.6119% (minimum 95%, Baseline (adaptation disabled)); tongue: 55.7803% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.5198% (minimum 97%, Baseline (adaptation disabled))",0,13,partial,31.7,28.6,24.8,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 2); parathyroid gland: 26.2 nTPM (protected, limit 2); small intestine: 25.5 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); salivary gland: 21.4 nTPM (protected, limit 2); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 2); rectum: 19.6 nTPM (protected, limit 2); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 2); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 2); smooth muscle: 15.9 nTPM (vital, limit 1); adipose tissue: 15.7 nTPM (manageable, limit 5); tongue: 15.3 nTPM (protected, limit 2); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (manageable, limit 5); thymus: 14.1 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); esophagus: 12.2 nTPM (protected, limit 2); skin: 12.1 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197217,ENTPD4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.512358,-0.567077,-0.611569
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.1429% (minimum 80%, Supported); adrenal gland: 63.4868% (minimum 99%, Missing); amygdala: 68.1979% (minimum 99%, Missing); basal ganglia: 68.6833% (minimum 99%, Missing); bone marrow: 38.9899% (minimum 99%, Missing); cerebellum: 54.0616% (minimum 99%, Missing); cerebral cortex: 49.1094% (minimum 99%, Missing); choroid plexus: 66.7820% (minimum 99%, Missing); colon: 50.2604% (minimum 97%, Missing); duodenum: 52.4457% (minimum 99%, Missing); esophagus: 61.2698% (minimum 90%, Supported); heart muscle: 48.6146% (minimum 97%, Supported); hippocampal formation: 63.6964% (minimum 99%, Missing); hypothalamus: 65.2027% (minimum 99%, Missing); kidney: 62.0579% (minimum 99%, Missing); liver: 59.0214% (minimum 97%, Supported); lung: 50.0000% (minimum 99%, Missing); lymph node: 40.2923% (minimum 97%, Missing); midbrain: 64.3333% (minimum 99%, Missing); pancreas: 48.1297% (minimum 99%, Missing); parathyroid gland: 42.4176% (minimum 97%, Missing); pituitary gland: 52.0216% (minimum 99%, Missing); rectum: 49.6144% (minimum 97%, Missing); retina: 37.8431% (minimum 99%, Missing); salivary gland: 47.4201% (minimum 97%, Missing); skeletal muscle: 56.7647% (minimum 99%, Missing); skin: 61.4650% (minimum 95%, Missing); small intestine: 43.0804% (minimum 99%, Missing); smooth muscle: 54.8295% (minimum 97%, Supported); spinal cord: 64.1196% (minimum 99%, Missing); spleen: 43.7642% (minimum 95%, Missing); stomach: 49.4872% (minimum 97%, Missing); thymus: 57.7844% (minimum 95%, Missing); thyroid gland: 57.6119% (minimum 95%, Missing); tongue: 55.7803% (minimum 97%, Missing); urinary bladder: 54.5198% (minimum 97%, Missing)",0,13,partial,31.7,28.6,24.8,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 2); parathyroid gland: 26.2 nTPM (protected, limit 2); small intestine: 25.5 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); salivary gland: 21.4 nTPM (protected, limit 2); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 3); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 2); rectum: 19.6 nTPM (protected, limit 2); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 2); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 2); smooth muscle: 15.9 nTPM (vital, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 15); tongue: 15.3 nTPM (protected, limit 2); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (manageable, limit 5); thymus: 14.1 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 3); esophagus: 12.2 nTPM (protected, limit 6); skin: 12.1 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197217,ENTPD4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.512358,-0.567077,-0.611569
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197233,OR1J2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197233,OR1J2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197233,OR1J2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,6.8,2.7,4.1,"retina: 6.8 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197275,RAD54B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.0909% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.7407% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.0909% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 71.0145% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.0909% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.0909% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.1233% (minimum 99%, Baseline (adaptation disabled)); colon: 76.5625% (minimum 97%, Baseline (adaptation disabled)); duodenum: 77.7778% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.0323% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 89.0909% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.4528% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.0909% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.9649% (minimum 99%, Baseline (adaptation disabled)); liver: 77.7778% (minimum 99%, Baseline (adaptation disabled)); lung: 87.5000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.4737% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.9649% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.0909% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 81.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.0145% (minimum 97%, Baseline (adaptation disabled)); retina: 41.8803% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.9649% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.2308% (minimum 99%, Baseline (adaptation disabled)); skin: 73.1343% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.3279% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.0508% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.5000% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.4828% (minimum 95%, Baseline (adaptation disabled)); stomach: 76.5625% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.4444% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.2308% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 81.6667% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,6.8,2.7,4.1,"retina: 6.8 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197275,RAD54B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.405556,-0.325263,-0.571197
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 89.0909% (minimum 95%, Missing); adrenal gland: 87.5000% (minimum 95%, Enhanced); amygdala: 90.7407% (minimum 99%, Missing); basal ganglia: 89.0909% (minimum 99%, Missing); bone marrow: 71.0145% (minimum 99%, Missing); cerebellum: 89.0909% (minimum 99%, Missing); cerebral cortex: 89.0909% (minimum 99%, Missing); choroid plexus: 67.1233% (minimum 99%, Missing); colon: 76.5625% (minimum 97%, Missing); duodenum: 77.7778% (minimum 99%, Missing); esophagus: 79.0323% (minimum 97%, Missing); heart muscle: 89.0909% (minimum 95%, Enhanced); hippocampal formation: 92.4528% (minimum 99%, Missing); hypothalamus: 89.0909% (minimum 99%, Missing); kidney: 85.9649% (minimum 99%, Missing); liver: 77.7778% (minimum 99%, Missing); lung: 87.5000% (minimum 99%, Missing); lymph node: 64.4737% (minimum 97%, Missing); midbrain: 87.5000% (minimum 99%, Missing); pancreas: 85.9649% (minimum 99%, Missing); parathyroid gland: 89.0909% (minimum 97%, Missing); pituitary gland: 81.6667% (minimum 99%, Missing); rectum: 71.0145% (minimum 97%, Missing); retina: 41.8803% (minimum 99%, Missing); salivary gland: 85.9649% (minimum 97%, Missing); skeletal muscle: 94.2308% (minimum 95%, Enhanced); skin: 73.1343% (minimum 95%, Missing); small intestine: 80.3279% (minimum 99%, Missing); smooth muscle: 83.0508% (minimum 95%, Enhanced); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 84.4828% (minimum 95%, Missing); stomach: 76.5625% (minimum 97%, Missing); thymus: 54.4444% (minimum 95%, Missing); thyroid gland: 81.6667% (minimum 95%, Missing); tongue: 94.2308% (minimum 97%, Missing); urinary bladder: 81.6667% (minimum 97%, Missing)",0,4,partial,6.8,2.7,4.1,"retina: 6.8 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197275,RAD54B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.405556,-0.325263,-0.571197
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.9,6.2,3.9,"parathyroid gland: 6.2 nTPM (protected, limit 2); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); pituitary gland: 3.7 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); colon: 3 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197279,ZNF165,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.4824% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.9697% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.8660% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.9697% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.4824% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.6680% (minimum 99%, Baseline (adaptation disabled)); colon: 86.4865% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.8778% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.7196% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.4824% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.9697% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.5224% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.3559% (minimum 99%, Baseline (adaptation disabled)); liver: 88.8889% (minimum 99%, Baseline (adaptation disabled)); lung: 88.4793% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.3077% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.9697% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.6723% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.5906% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.8428% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.7021% (minimum 97%, Baseline (adaptation disabled)); retina: 89.7196% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.9953% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.5224% (minimum 99%, Baseline (adaptation disabled)); skin: 93.6585% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.3023% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.4824% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.9592% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.1176% (minimum 95%, Baseline (adaptation disabled)); stomach: 85.7143% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 83.1169% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 85.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.9,6.2,3.9,"parathyroid gland: 6.2 nTPM (protected, limit 2); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); pituitary gland: 3.7 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); colon: 3 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197279,ZNF165,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.118831,-0.214094,-0.19332
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.4824% (minimum 99%, Missing); amygdala: 96.9697% (minimum 99%, Missing); basal ganglia: 96.0000% (minimum 99%, Missing); bone marrow: 91.8660% (minimum 99%, Missing); cerebellum: 96.9697% (minimum 99%, Missing); cerebral cortex: 96.4824% (minimum 99%, Missing); choroid plexus: 79.6680% (minimum 99%, Missing); colon: 86.4865% (minimum 97%, Missing); duodenum: 86.8778% (minimum 99%, Missing); esophagus: 89.7196% (minimum 97%, Missing); heart muscle: 96.4824% (minimum 99%, Missing); hippocampal formation: 96.9697% (minimum 99%, Missing); hypothalamus: 95.5224% (minimum 99%, Missing); kidney: 81.3559% (minimum 99%, Missing); liver: 88.8889% (minimum 99%, Missing); lung: 88.4793% (minimum 99%, Missing); lymph node: 92.3077% (minimum 97%, Missing); midbrain: 96.9697% (minimum 99%, Missing); pancreas: 80.6723% (minimum 99%, Missing); parathyroid gland: 75.5906% (minimum 97%, Missing); pituitary gland: 83.8428% (minimum 99%, Missing); rectum: 81.7021% (minimum 97%, Missing); retina: 89.7196% (minimum 99%, Missing); salivary gland: 90.9953% (minimum 97%, Missing); skeletal muscle: 95.5224% (minimum 99%, Missing); skin: 93.6585% (minimum 95%, Missing); small intestine: 89.3023% (minimum 99%, Missing); smooth muscle: 96.4824% (minimum 99%, Missing); spinal cord: 97.9592% (minimum 99%, Missing); spleen: 94.1176% (minimum 95%, Missing); stomach: 85.7143% (minimum 97%, Missing); thyroid gland: 83.1169% (minimum 95%, Missing); urinary bladder: 85.3333% (minimum 97%, Missing)",0,80,unavailable,4.9,6.2,3.9,"parathyroid gland: 6.2 nTPM (protected, limit 2); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 2); pituitary gland: 3.7 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 2); stomach: 3.2 nTPM (protected, limit 2); colon: 3 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197279,ZNF165,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.118831,-0.214094,-0.19332
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197309,OR10D3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197309,OR10D3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197309,OR10D3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,20.5,26.2,22,"esophagus: 26.2 nTPM (protected, limit 2); thymus: 22 nTPM (manageable, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 2); urinary bladder: 18.1 nTPM (protected, limit 2); skin: 17.9 nTPM (manageable, limit 5); stomach: 17.5 nTPM (protected, limit 2); salivary gland: 16.2 nTPM (protected, limit 2); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 2); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 2); spleen: 13.8 nTPM (manageable, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 2); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); adrenal gland: 11.5 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); rectum: 11.4 nTPM (protected, limit 2); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197343,ZNF655,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.2500% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 55.5985% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.7168% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.4545% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 62.0690% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 63.4361% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 55.1724% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.5366% (minimum 99%, Baseline (adaptation disabled)); colon: 48.9796% (minimum 97%, Baseline (adaptation disabled)); duodenum: 48.4848% (minimum 99%, Baseline (adaptation disabled)); esophagus: 35.4680% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.7168% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.1579% (minimum 99%, Baseline (adaptation disabled)); kidney: 51.9856% (minimum 99%, Baseline (adaptation disabled)); liver: 50.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 49.3151% (minimum 99%, Baseline (adaptation disabled)); lymph node: 42.8571% (minimum 97%, Baseline (adaptation disabled)); midbrain: 57.6000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 41.2607% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.8834% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.2857% (minimum 99%, Baseline (adaptation disabled)); rectum: 55.8140% (minimum 97%, Baseline (adaptation disabled)); retina: 63.7168% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 47.0588% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 54.1353% (minimum 99%, Baseline (adaptation disabled)); skin: 44.5820% (minimum 95%, Baseline (adaptation disabled)); small intestine: 51.6129% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.0311% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 51.6129% (minimum 99%, Baseline (adaptation disabled)); spleen: 51.0638% (minimum 95%, Baseline (adaptation disabled)); stomach: 45.1411% (minimum 97%, Baseline (adaptation disabled)); thymus: 39.5604% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.5985% (minimum 95%, Baseline (adaptation disabled)); tongue: 52.5547% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 44.3077% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,20.5,26.2,22,"esophagus: 26.2 nTPM (protected, limit 2); thymus: 22 nTPM (manageable, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 2); urinary bladder: 18.1 nTPM (protected, limit 2); skin: 17.9 nTPM (manageable, limit 5); stomach: 17.5 nTPM (protected, limit 2); salivary gland: 16.2 nTPM (protected, limit 2); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 2); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 2); spleen: 13.8 nTPM (manageable, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 2); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); adrenal gland: 11.5 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); rectum: 11.4 nTPM (protected, limit 2); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197343,ZNF655,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.554396,-0.61532,-0.577393
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.2500% (minimum 95%, Missing); adrenal gland: 55.5985% (minimum 99%, Missing); amygdala: 63.7168% (minimum 99%, Missing); basal ganglia: 65.4545% (minimum 99%, Missing); bone marrow: 62.0690% (minimum 99%, Missing); cerebellum: 63.4361% (minimum 99%, Missing); cerebral cortex: 55.1724% (minimum 99%, Missing); choroid plexus: 58.5366% (minimum 99%, Missing); colon: 48.9796% (minimum 97%, Missing); duodenum: 48.4848% (minimum 99%, Missing); esophagus: 35.4680% (minimum 97%, Missing); heart muscle: 64.0000% (minimum 99%, Missing); hippocampal formation: 63.7168% (minimum 99%, Missing); hypothalamus: 63.1579% (minimum 99%, Missing); kidney: 51.9856% (minimum 99%, Missing); liver: 50.0000% (minimum 99%, Uncertain); lung: 49.3151% (minimum 99%, Missing); lymph node: 42.8571% (minimum 97%, Missing); midbrain: 57.6000% (minimum 99%, Missing); pancreas: 41.2607% (minimum 99%, Missing); parathyroid gland: 50.8834% (minimum 97%, Uncertain); pituitary gland: 64.2857% (minimum 99%, Missing); rectum: 55.8140% (minimum 97%, Missing); retina: 63.7168% (minimum 99%, Missing); salivary gland: 47.0588% (minimum 97%, Missing); skeletal muscle: 54.1353% (minimum 99%, Missing); skin: 44.5820% (minimum 95%, Missing); small intestine: 51.6129% (minimum 99%, Missing); smooth muscle: 56.0311% (minimum 99%, Missing); spinal cord: 51.6129% (minimum 99%, Missing); spleen: 51.0638% (minimum 95%, Missing); stomach: 45.1411% (minimum 97%, Missing); thymus: 39.5604% (minimum 95%, Missing); thyroid gland: 55.5985% (minimum 95%, Missing); tongue: 52.5547% (minimum 97%, Missing); urinary bladder: 44.3077% (minimum 97%, Missing)",0,2,partial,20.5,26.2,22,"esophagus: 26.2 nTPM (protected, limit 2); thymus: 22 nTPM (manageable, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 2); urinary bladder: 18.1 nTPM (protected, limit 2); skin: 17.9 nTPM (manageable, limit 5); stomach: 17.5 nTPM (protected, limit 2); salivary gland: 16.2 nTPM (protected, limit 2); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 2); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 2); spleen: 13.8 nTPM (manageable, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 2); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); adrenal gland: 11.5 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); rectum: 11.4 nTPM (protected, limit 2); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197343,ZNF655,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.554396,-0.61532,-0.577393
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,35.9,3.7,4.5,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000197360,ZNF98,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.0990% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.7917% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.0990% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.5390% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.8495% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.8495% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.9837% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9130% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9130% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 93.8144% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.2157% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.8144% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.9820% (minimum 99%, Baseline (adaptation disabled)); lung: 97.8495% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.7895% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.2157% (minimum 99%, Baseline (adaptation disabled)); pancreas: 20.2222% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.0937% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.8085% (minimum 99%, Baseline (adaptation disabled)); retina: 93.8144% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.9192% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.9130% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.3495% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.7895% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.8085% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 66.9118% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.7917% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,35.9,3.7,4.5,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000197360,ZNF98,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.280882,-0.259063,-0.787778
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.0990% (minimum 95%, Missing); adrenal gland: 94.7917% (minimum 99%, Missing); amygdala: 90.0990% (minimum 99%, Missing); basal ganglia: 64.5390% (minimum 99%, Missing); bone marrow: 97.8495% (minimum 99%, Missing); cerebellum: 97.8495% (minimum 99%, Missing); cerebral cortex: 73.9837% (minimum 99%, Missing); choroid plexus: 98.9130% (minimum 99%, Missing); duodenum: 98.9130% (minimum 99%, Missing); heart muscle: 93.8144% (minimum 99%, Missing); hippocampal formation: 89.2157% (minimum 99%, Missing); hypothalamus: 93.8144% (minimum 99%, Missing); kidney: 81.9820% (minimum 99%, Missing); lung: 97.8495% (minimum 99%, Missing); lymph node: 95.7895% (minimum 97%, Missing); midbrain: 89.2157% (minimum 99%, Missing); pancreas: 20.2222% (minimum 99%, Missing); parathyroid gland: 71.0937% (minimum 97%, Missing); pituitary gland: 96.8085% (minimum 99%, Missing); retina: 93.8144% (minimum 99%, Missing); salivary gland: 91.9192% (minimum 97%, Missing); small intestine: 98.9130% (minimum 99%, Missing); smooth muscle: 88.3495% (minimum 99%, Missing); spinal cord: 95.7895% (minimum 99%, Missing); stomach: 96.8085% (minimum 97%, Missing); thyroid gland: 66.9118% (minimum 95%, Missing); urinary bladder: 94.7917% (minimum 97%, Missing)",0,80,unavailable,35.9,3.7,4.5,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000197360,ZNF98,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.280882,-0.259063,-0.787778
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,11.2,12.6,10.2,"lymph node: 12.6 nTPM (protected, limit 2); rectum: 11.8 nTPM (protected, limit 2); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); skin: 9.5 nTPM (manageable, limit 5); spleen: 9.2 nTPM (manageable, limit 5); stomach: 8.8 nTPM (protected, limit 2); thyroid gland: 8.3 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 2); pancreas: 7.4 nTPM (vital, limit 1); adipose tissue: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); esophagus: 5.8 nTPM (protected, limit 2); urinary bladder: 5.3 nTPM (protected, limit 2); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197372,ZNF675,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.3564% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.0383% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.0337% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.1445% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 53.7190% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.2222% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 54.8523% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.3810% (minimum 99%, Baseline (adaptation disabled)); colon: 61.9048% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.1489% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.2469% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.4286% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.8636% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.2222% (minimum 99%, Baseline (adaptation disabled)); liver: 67.3575% (minimum 99%, Baseline (adaptation disabled)); lung: 66.3265% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.7812% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.8443% (minimum 99%, Baseline (adaptation disabled)); pancreas: 63.7255% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.3564% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.2483% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.4194% (minimum 97%, Baseline (adaptation disabled)); retina: 55.7940% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.3265% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 79.7546% (minimum 99%, Baseline (adaptation disabled)); skin: 57.7778% (minimum 95%, Baseline (adaptation disabled)); small intestine: 69.1489% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.4706% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.1445% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.5586% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.6330% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.0345% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.0329% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.7879% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.0383% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,11.2,12.6,10.2,"lymph node: 12.6 nTPM (protected, limit 2); rectum: 11.8 nTPM (protected, limit 2); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); skin: 9.5 nTPM (manageable, limit 5); spleen: 9.2 nTPM (manageable, limit 5); stomach: 8.8 nTPM (protected, limit 2); thyroid gland: 8.3 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 2); pancreas: 7.4 nTPM (vital, limit 1); adipose tissue: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); esophagus: 5.8 nTPM (protected, limit 2); urinary bladder: 5.3 nTPM (protected, limit 2); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197372,ZNF675,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.389655,-0.462187,-0.45281
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.3564% (minimum 95%, Missing); adrenal gland: 71.0383% (minimum 99%, Missing); amygdala: 73.0337% (minimum 99%, Missing); basal ganglia: 75.1445% (minimum 99%, Missing); bone marrow: 53.7190% (minimum 99%, Missing); cerebellum: 72.2222% (minimum 99%, Missing); cerebral cortex: 54.8523% (minimum 99%, Missing); choroid plexus: 77.3810% (minimum 99%, Missing); colon: 61.9048% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 69.1489% (minimum 97%, Missing); heart muscle: 80.2469% (minimum 99%, Missing); hippocampal formation: 71.4286% (minimum 99%, Missing); hypothalamus: 73.8636% (minimum 99%, Missing); kidney: 72.2222% (minimum 99%, Missing); liver: 67.3575% (minimum 99%, Missing); lung: 66.3265% (minimum 99%, Missing); lymph node: 50.7812% (minimum 97%, Missing); midbrain: 77.8443% (minimum 99%, Missing); pancreas: 63.7255% (minimum 99%, Missing); parathyroid gland: 64.3564% (minimum 97%, Missing); pituitary gland: 87.2483% (minimum 99%, Missing); rectum: 52.4194% (minimum 97%, Missing); retina: 55.7940% (minimum 99%, Missing); salivary gland: 66.3265% (minimum 97%, Missing); skeletal muscle: 79.7546% (minimum 99%, Missing); skin: 57.7778% (minimum 95%, Missing); small intestine: 69.1489% (minimum 99%, Missing); smooth muscle: 76.4706% (minimum 99%, Missing); spinal cord: 75.1445% (minimum 99%, Missing); spleen: 58.5586% (minimum 95%, Missing); stomach: 59.6330% (minimum 97%, Missing); thymus: 56.0345% (minimum 95%, Missing); thyroid gland: 61.0329% (minimum 95%, Missing); tongue: 78.7879% (minimum 97%, Missing); urinary bladder: 71.0383% (minimum 97%, Missing)",0,80,unavailable,11.2,12.6,10.2,"lymph node: 12.6 nTPM (protected, limit 2); rectum: 11.8 nTPM (protected, limit 2); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); skin: 9.5 nTPM (manageable, limit 5); spleen: 9.2 nTPM (manageable, limit 5); stomach: 8.8 nTPM (protected, limit 2); thyroid gland: 8.3 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 2); pancreas: 7.4 nTPM (vital, limit 1); adipose tissue: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 2); salivary gland: 6.6 nTPM (protected, limit 2); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); esophagus: 5.8 nTPM (protected, limit 2); urinary bladder: 5.3 nTPM (protected, limit 2); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197372,ZNF675,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.389655,-0.462187,-0.45281
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.2,1.7,0.2,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000197410,DCHS2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.8571% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.2222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 37.1429% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.8571% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 43.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 43.3333% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 68.4211% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.9048% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.8571% (minimum 99%, Baseline (adaptation disabled)); lung: 92.8571% (minimum 99%, Baseline (adaptation disabled)); midbrain: 68.4211% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 72.2222% (minimum 99%, Baseline (adaptation disabled)); retina: 92.8571% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.8571% (minimum 97%, Baseline (adaptation disabled)); skin: 86.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.2500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.4706% (minimum 99%, Baseline (adaptation disabled)); stomach: 52.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.4211% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.2,1.7,0.2,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000197410,DCHS2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0833333,-0.536667,-0.618571
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.8571% (minimum 99%, Missing); amygdala: 72.2222% (minimum 99%, Missing); basal ganglia: 37.1429% (minimum 99%, Missing); cerebellum: 92.8571% (minimum 99%, Missing); cerebral cortex: 43.3333% (minimum 99%, Missing); colon: 43.3333% (minimum 97%, Missing); hippocampal formation: 68.4211% (minimum 99%, Missing); hypothalamus: 61.9048% (minimum 99%, Missing); kidney: 92.8571% (minimum 99%, Missing); lung: 92.8571% (minimum 99%, Missing); midbrain: 68.4211% (minimum 99%, Missing); pituitary gland: 72.2222% (minimum 99%, Missing); retina: 92.8571% (minimum 99%, Missing); salivary gland: 92.8571% (minimum 97%, Missing); skin: 86.6667% (minimum 95%, Missing); small intestine: 81.2500% (minimum 99%, Missing); smooth muscle: 92.8571% (minimum 99%, Missing); spinal cord: 76.4706% (minimum 99%, Missing); stomach: 52.0000% (minimum 97%, Missing); urinary bladder: 68.4211% (minimum 97%, Missing)",0,80,unavailable,2.2,1.7,0.2,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000197410,DCHS2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0833333,-0.536667,-0.618571
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,54.5,2.4,0,"retina: 54.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000197416,FABP12,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 98.6301% (minimum 99%, Baseline (adaptation disabled)); duodenum: 94.7368% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.0000% (minimum 97%, Baseline (adaptation disabled)); lung: 96.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.7368% (minimum 99%, Baseline (adaptation disabled)); retina: 11.6694% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.7368% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,54.5,2.4,0,"retina: 54.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000197416,FABP12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,-0.22,-0.873306
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 98.6301% (minimum 99%, Missing); duodenum: 94.7368% (minimum 95%, Enhanced); esophagus: 75.0000% (minimum 80%, Enhanced); pituitary gland: 94.7368% (minimum 99%, Missing); retina: 11.6694% (minimum 99%, Missing)",0,3,partial,54.5,2.4,0,"retina: 54.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000197416,FABP12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,-0.05,-0.873306
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197437,OR13G1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197437,OR13G1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197437,OR13G1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,8,partial,8,5.5,6.9,"retina: 8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 3); heart muscle: 3.2 nTPM (vital, limit 3); pancreas: 3.2 nTPM (vital, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197557,IFT70A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.0513% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.2105% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.2727% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.4783% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.2039% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.4194% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.5906% (minimum 99%, Baseline (adaptation disabled)); colon: 79.3388% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.7143% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.4865% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.0734% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.4865% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 77.4194% (minimum 99%, Baseline (adaptation disabled)); lung: 79.3388% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8889% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.2727% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.5762% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.7586% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 54.5455% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.5906% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.4865% (minimum 99%, Baseline (adaptation disabled)); skin: 89.7196% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.6885% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.7196% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.8889% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.0488% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.7143% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.1818% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.8889% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.8889% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,8,5.5,6.9,"retina: 8 nTPM (vital, limit 1); thyroid gland: 6.9 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 2); kidney: 4.8 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); liver: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); stomach: 2.7 nTPM (protected, limit 2); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197557,IFT70A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.368182,-0.334238,-0.444545
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 84.2105% (minimum 97%, Supported); amygdala: 87.2727% (minimum 99%, Missing); basal ganglia: 83.4783% (minimum 99%, Missing); bone marrow: 96.0000% (minimum 97%, Supported); cerebellum: 93.2039% (minimum 97%, Supported); cerebral cortex: 77.4194% (minimum 97%, Supported); choroid plexus: 75.5906% (minimum 99%, Missing); colon: 79.3388% (minimum 97%, Missing); duodenum: 85.7143% (minimum 99%, Missing); esophagus: 86.4865% (minimum 90%, Supported); heart muscle: 75.0000% (minimum 97%, Supported); hippocampal formation: 88.0734% (minimum 99%, Missing); hypothalamus: 86.4865% (minimum 99%, Missing); kidney: 66.6667% (minimum 97%, Supported); liver: 77.4194% (minimum 97%, Supported); lung: 79.3388% (minimum 97%, Supported); lymph node: 88.8889% (minimum 90%, Supported); midbrain: 87.2727% (minimum 99%, Missing); pancreas: 75.0000% (minimum 97%, Supported); parathyroid gland: 63.5762% (minimum 90%, Supported); pituitary gland: 82.7586% (minimum 99%, Missing); rectum: 80.0000% (minimum 97%, Missing); retina: 54.5455% (minimum 99%, Missing); salivary gland: 75.5906% (minimum 90%, Supported); skeletal muscle: 86.4865% (minimum 97%, Supported); small intestine: 85.7143% (minimum 99%, Missing); smooth muscle: 78.6885% (minimum 97%, Supported); spinal cord: 89.7196% (minimum 99%, Missing); stomach: 78.0488% (minimum 90%, Supported); thymus: 85.7143% (minimum 95%, Missing); thyroid gland: 58.1818% (minimum 80%, Supported); tongue: 88.8889% (minimum 97%, Missing); urinary bladder: 88.8889% (minimum 90%, Supported)",0,8,partial,8,5.5,6.9,"retina: 8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 3); heart muscle: 3.2 nTPM (vital, limit 3); pancreas: 3.2 nTPM (vital, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); colon: 2.5 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197557,IFT70A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.218182,-0.264238,-0.444545
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,2.6,2.4,3.4,"retina: 2.6 nTPM (vital, limit 1); lymph node: 2.4 nTPM (protected, limit 2); parathyroid gland: 2.4 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197566,ZNF624,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.6032% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.0370% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.4561% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.4561% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.0345% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.4545% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.3077% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 73.4375% (minimum 97%, Baseline (adaptation disabled)); duodenum: 78.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.6610% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.0492% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.4561% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.9286% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.3077% (minimum 99%, Baseline (adaptation disabled)); liver: 85.4545% (minimum 99%, Baseline (adaptation disabled)); lung: 71.2121% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.1972% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.0345% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.4545% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.1972% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.1569% (minimum 99%, Baseline (adaptation disabled)); rectum: 73.4375% (minimum 97%, Baseline (adaptation disabled)); retina: 64.3836% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.4545% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.1569% (minimum 99%, Baseline (adaptation disabled)); skin: 75.8065% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.2121% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.4375% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.0247% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.3077% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.0390% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 67.1429% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.9286% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.3333% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,2.6,2.4,3.4,"retina: 2.6 nTPM (vital, limit 1); lymph node: 2.4 nTPM (protected, limit 2); parathyroid gland: 2.4 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197566,ZNF624,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.369753,-0.308028,-0.346164
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.6032% (minimum 95%, Missing); adrenal gland: 87.0370% (minimum 99%, Missing); amygdala: 82.4561% (minimum 99%, Missing); basal ganglia: 82.4561% (minimum 99%, Missing); bone marrow: 81.0345% (minimum 99%, Missing); cerebellum: 85.4545% (minimum 99%, Missing); cerebral cortex: 72.3077% (minimum 99%, Missing); choroid plexus: 94.0000% (minimum 99%, Missing); colon: 73.4375% (minimum 97%, Missing); duodenum: 78.3333% (minimum 99%, Missing); esophagus: 79.6610% (minimum 97%, Missing); heart muscle: 77.0492% (minimum 99%, Missing); hippocampal formation: 82.4561% (minimum 99%, Missing); hypothalamus: 83.9286% (minimum 99%, Missing); kidney: 72.3077% (minimum 99%, Missing); liver: 85.4545% (minimum 99%, Missing); lung: 71.2121% (minimum 99%, Missing); lymph node: 66.1972% (minimum 97%, Missing); midbrain: 81.0345% (minimum 99%, Missing); pancreas: 85.4545% (minimum 99%, Missing); parathyroid gland: 66.1972% (minimum 97%, Missing); pituitary gland: 92.1569% (minimum 99%, Missing); rectum: 73.4375% (minimum 97%, Missing); retina: 64.3836% (minimum 99%, Missing); salivary gland: 85.4545% (minimum 97%, Missing); skeletal muscle: 92.1569% (minimum 99%, Missing); skin: 75.8065% (minimum 95%, Missing); small intestine: 78.3333% (minimum 99%, Missing); smooth muscle: 71.2121% (minimum 99%, Missing); spinal cord: 73.4375% (minimum 99%, Missing); spleen: 58.0247% (minimum 95%, Missing); stomach: 72.3077% (minimum 97%, Missing); thymus: 61.0390% (minimum 95%, Missing); thyroid gland: 67.1429% (minimum 95%, Missing); tongue: 83.9286% (minimum 97%, Missing); urinary bladder: 78.3333% (minimum 97%, Missing)",0,1,partial,2.6,2.4,3.4,"retina: 2.6 nTPM (vital, limit 1); lymph node: 2.4 nTPM (protected, limit 2); parathyroid gland: 2.4 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197566,ZNF624,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.369753,-0.308028,-0.346164
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,0,routine_complete,5.6,2.9,1.2,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197584,KCNMB2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.3418% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.3141% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.1003% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2906% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.7863% (minimum 99%, Baseline (adaptation disabled)); colon: 96.9101% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.5714% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 86.0349% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.5635% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.9919% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.2698% (minimum 99%, Baseline (adaptation disabled)); lung: 96.9101% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.4959% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.8438% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.8333% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5714% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.0413% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.3039% (minimum 99%, Baseline (adaptation disabled)); stomach: 92.2460% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,5.6,2.9,1.2,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197584,KCNMB2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0163866,-0.0475401,-0.129651
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.3418% (minimum 99%, Missing); amygdala: 90.3141% (minimum 99%, Missing); basal ganglia: 96.1003% (minimum 99%, Missing); cerebellum: 98.2906% (minimum 99%, Missing); cerebral cortex: 87.7863% (minimum 99%, Missing); colon: 96.9101% (minimum 97%, Missing); duodenum: 98.5714% (minimum 99%, Missing); heart muscle: 86.0349% (minimum 99%, Missing); hippocampal formation: 87.5635% (minimum 99%, Missing); hypothalamus: 92.9919% (minimum 99%, Missing); kidney: 91.2698% (minimum 99%, Missing); lung: 96.9101% (minimum 99%, Missing); midbrain: 93.4959% (minimum 99%, Missing); pancreas: 89.8438% (minimum 99%, Missing); pituitary gland: 95.8333% (minimum 99%, Missing); small intestine: 98.5714% (minimum 99%, Missing); smooth muscle: 95.0413% (minimum 99%, Uncertain); spinal cord: 95.3039% (minimum 99%, Missing); stomach: 92.2460% (minimum 97%, Missing)",0,0,routine_complete,5.6,2.9,1.2,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197584,KCNMB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0163866,-0.0475401,-0.129651
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000197587,DMBX1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 90.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 69.2308% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 56.2500% (minimum 99%, Baseline (adaptation disabled)); skin: 90.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.8182% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 81.8182% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000197587,DMBX1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.131818,-0.151818,-0.4275
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"bone marrow: 90.0000% (minimum 99%, Missing); choroid plexus: 90.0000% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); midbrain: 69.2308% (minimum 99%, Missing); parathyroid gland: 90.0000% (minimum 97%, Missing); pituitary gland: 60.0000% (minimum 99%, Missing); retina: 56.2500% (minimum 99%, Missing); skin: 90.0000% (minimum 95%, Missing); thyroid gland: 81.8182% (minimum 95%, Missing); urinary bladder: 81.8182% (minimum 97%, Missing)",0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000197587,DMBX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.131818,-0.151818,-0.4275
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,False,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000197617,VN1R5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000197617,VN1R5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000197617,VN1R5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197651,CCER1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197651,CCER1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000197651,CCER1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,6,partial,1.2,0.1,0.1,,adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000197653,DNAH10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.0233% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.1064% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 76.9231% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.9565% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.5610% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.5610% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.5610% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.9565% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.1064% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5610% (minimum 99%, Baseline (adaptation disabled)); lung: 78.4314% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.2381% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.5610% (minimum 99%, Baseline (adaptation disabled)); retina: 95.2381% (minimum 99%, Baseline (adaptation disabled)); small intestine: 93.0233% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 85.1064% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000197653,DNAH10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0256098,0.00560976,-0.220769
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.0233% (minimum 99%, Missing); basal ganglia: 85.1064% (minimum 99%, Missing); bone marrow: 76.9231% (minimum 95%, Enhanced); cerebellum: 86.9565% (minimum 95%, Enhanced); choroid plexus: 90.9091% (minimum 99%, Missing); hippocampal formation: 86.9565% (minimum 99%, Missing); hypothalamus: 85.1064% (minimum 99%, Missing); kidney: 97.5610% (minimum 99%, Missing); lung: 78.4314% (minimum 95%, Enhanced); midbrain: 95.2381% (minimum 99%, Missing); pituitary gland: 97.5610% (minimum 99%, Missing); retina: 95.2381% (minimum 99%, Missing); small intestine: 93.0233% (minimum 95%, Enhanced); spinal cord: 85.1064% (minimum 99%, Missing)",0,6,partial,1.2,0.1,0.1,,adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000197653,DNAH10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,0.03,-0.180769
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,18.7,"skin: 18.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000197683,KRTAP26-1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 76.4706% (minimum 95%, Baseline (adaptation disabled)); skin: 6.5000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,18.7,"skin: 18.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000197683,KRTAP26-1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.885,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 76.4706% (minimum 95%, Missing); skin: 6.5000% (minimum 95%, Missing)",0,80,unavailable,0,0,18.7,"skin: 18.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000197683,KRTAP26-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.885,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.9,1.3,1.8,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197714,ZNF460,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 31.4286% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.8621% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 27.1605% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.7059% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 68.7500% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 70.9677% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.7059% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.1111% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.8621% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.5714% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 61.1111% (minimum 99%, Baseline (adaptation disabled)); lung: 62.8571% (minimum 99%, Baseline (adaptation disabled)); lymph node: 73.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.5714% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.7500% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 62.8571% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.8947% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.5714% (minimum 97%, Baseline (adaptation disabled)); retina: 46.8085% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.8571% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 59.4595% (minimum 99%, Baseline (adaptation disabled)); skin: 55.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.8621% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.9677% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.1111% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.9677% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.7500% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.1111% (minimum 95%, Baseline (adaptation disabled)); tongue: 64.7059% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.6667% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.9,1.3,1.8,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197714,ZNF460,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4,-0.341429,-0.718395
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 95%, Missing); adrenal gland: 31.4286% (minimum 99%, Missing); amygdala: 75.8621% (minimum 99%, Missing); basal ganglia: 73.3333% (minimum 99%, Missing); bone marrow: 27.1605% (minimum 99%, Missing); cerebellum: 64.7059% (minimum 99%, Missing); cerebral cortex: 68.7500% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 70.9677% (minimum 97%, Missing); duodenum: 88.0000% (minimum 99%, Missing); esophagus: 64.7059% (minimum 97%, Missing); heart muscle: 61.1111% (minimum 99%, Missing); hippocampal formation: 75.8621% (minimum 99%, Missing); hypothalamus: 78.5714% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 61.1111% (minimum 99%, Missing); lung: 62.8571% (minimum 99%, Missing); lymph node: 73.3333% (minimum 97%, Missing); midbrain: 78.5714% (minimum 99%, Missing); pancreas: 68.7500% (minimum 99%, Missing); parathyroid gland: 62.8571% (minimum 97%, Missing); pituitary gland: 57.8947% (minimum 99%, Missing); rectum: 78.5714% (minimum 97%, Missing); retina: 46.8085% (minimum 99%, Missing); salivary gland: 62.8571% (minimum 97%, Missing); skeletal muscle: 59.4595% (minimum 99%, Missing); skin: 55.0000% (minimum 95%, Missing); small intestine: 75.8621% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 70.9677% (minimum 99%, Missing); spleen: 61.1111% (minimum 95%, Missing); stomach: 70.9677% (minimum 97%, Missing); thymus: 68.7500% (minimum 95%, Missing); thyroid gland: 61.1111% (minimum 95%, Missing); tongue: 64.7059% (minimum 97%, Missing); urinary bladder: 66.6667% (minimum 97%, Missing)",0,80,unavailable,5.9,1.3,1.8,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197714,ZNF460,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4,-0.341429,-0.718395
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,96.9,3.6,5.2,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197748,CFAP43,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4071% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.4474% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.8855% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.5816% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.0332% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 36.4590% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.6703% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.3704% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.7015% (minimum 99%, Baseline (adaptation disabled)); lung: 87.5591% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.3688% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.3605% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 93.9189% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.0153% (minimum 99%, Baseline (adaptation disabled)); retina: 84.2424% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9324% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.5326% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 91.4474% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,96.9,3.6,5.2,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197748,CFAP43,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0355263,-0.0308108,-0.62541
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4071% (minimum 99%, Missing); amygdala: 91.4474% (minimum 99%, Missing); basal ganglia: 84.8855% (minimum 99%, Missing); cerebellum: 98.5816% (minimum 99%, Missing); cerebral cortex: 97.0332% (minimum 99%, Missing); choroid plexus: 36.4590% (minimum 99%, Missing); hippocampal formation: 85.6703% (minimum 99%, Missing); hypothalamus: 82.3704% (minimum 99%, Missing); kidney: 90.7015% (minimum 99%, Missing); lung: 87.5591% (minimum 99%, Missing); midbrain: 95.3688% (minimum 99%, Missing); pancreas: 96.3605% (minimum 99%, Missing); parathyroid gland: 93.9189% (minimum 97%, Missing); pituitary gland: 85.0153% (minimum 99%, Missing); retina: 84.2424% (minimum 99%, Missing); small intestine: 98.9324% (minimum 99%, Missing); spinal cord: 95.5326% (minimum 99%, Missing); thyroid gland: 91.4474% (minimum 95%, Missing)",0,80,unavailable,96.9,3.6,5.2,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000197748,CFAP43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0355263,-0.0308108,-0.62541
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.8,1.3,1.3,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000197768,STPG3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 91.5743% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.4057% (minimum 99%, Baseline (adaptation disabled)); liver: 96.4953% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.1765% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.3333% (minimum 99%, Baseline (adaptation disabled)); retina: 96.4953% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.9484% (minimum 97%, Baseline (adaptation disabled)); small intestine: 93.6508% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.8,1.3,1.3,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000197768,STPG3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0194836,-0.000516432,-0.0742572
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 91.5743% (minimum 99%, Missing); kidney: 97.4057% (minimum 99%, Missing); liver: 96.4953% (minimum 99%, Missing); pancreas: 97.1765% (minimum 99%, Missing); pituitary gland: 98.3333% (minimum 99%, Missing); retina: 96.4953% (minimum 99%, Missing); salivary gland: 96.9484% (minimum 97%, Missing); small intestine: 93.6508% (minimum 99%, Missing)",0,80,unavailable,3.8,1.3,1.3,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000197768,STPG3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0194836,-0.000516432,-0.0742572
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,4.2,3.4,3.5,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 2); rectum: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197779,ZNF81,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.5238% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.1395% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.7895% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.7895% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 43.8596% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 56.8182% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 54.3478% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 59.5238% (minimum 99%, Baseline (adaptation disabled)); colon: 52.0833% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.5000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 54.3478% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 42.3729% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.5676% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.4444% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 62.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 56.8182% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.1915% (minimum 97%, Baseline (adaptation disabled)); midbrain: 60.9756% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.5238% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 42.3729% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 53.1915% (minimum 99%, Baseline (adaptation disabled)); rectum: 47.1698% (minimum 97%, Baseline (adaptation disabled)); retina: 37.3134% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.1395% (minimum 99%, Baseline (adaptation disabled)); skin: 41.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.9756% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 53.1915% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 60.9756% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.0769% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.5238% (minimum 97%, Baseline (adaptation disabled)); thymus: 46.2963% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 47.1698% (minimum 95%, Baseline (adaptation disabled)); tongue: 73.5294% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.5556% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,4.2,3.4,3.5,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 1); rectum: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197779,ZNF81,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.533333,-0.546271,-0.616866
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.5238% (minimum 90%, Approved); adrenal gland: 58.1395% (minimum 99%, Missing); amygdala: 65.7895% (minimum 99%, Missing); basal ganglia: 65.7895% (minimum 99%, Missing); bone marrow: 43.8596% (minimum 98%, Approved); cerebellum: 56.8182% (minimum 99%, Missing); cerebral cortex: 54.3478% (minimum 99%, Missing); choroid plexus: 59.5238% (minimum 99%, Missing); colon: 52.0833% (minimum 97%, Missing); duodenum: 62.5000% (minimum 99%, Missing); esophagus: 54.3478% (minimum 97%, Missing); heart muscle: 42.3729% (minimum 99%, Missing); hippocampal formation: 67.5676% (minimum 99%, Missing); hypothalamus: 69.4444% (minimum 99%, Missing); kidney: 50.0000% (minimum 99%, Missing); liver: 62.5000% (minimum 99%, Missing); lung: 56.8182% (minimum 99%, Missing); lymph node: 53.1915% (minimum 97%, Missing); midbrain: 60.9756% (minimum 99%, Missing); pancreas: 59.5238% (minimum 99%, Missing); parathyroid gland: 42.3729% (minimum 97%, Missing); pituitary gland: 53.1915% (minimum 99%, Missing); rectum: 47.1698% (minimum 97%, Missing); retina: 37.3134% (minimum 99%, Missing); salivary gland: 62.5000% (minimum 97%, Missing); skeletal muscle: 58.1395% (minimum 99%, Missing); skin: 41.6667% (minimum 95%, Missing); small intestine: 60.9756% (minimum 99%, Missing); smooth muscle: 53.1915% (minimum 98%, Approved); spinal cord: 60.9756% (minimum 99%, Missing); spleen: 48.0769% (minimum 95%, Missing); stomach: 59.5238% (minimum 97%, Missing); thymus: 46.2963% (minimum 95%, Missing); thyroid gland: 47.1698% (minimum 95%, Missing); tongue: 73.5294% (minimum 97%, Missing); urinary bladder: 55.5556% (minimum 97%, Missing)",0,2,partial,4.2,3.4,3.5,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 2); bone marrow: 3.2 nTPM (vital, limit 2); rectum: 2.8 nTPM (protected, limit 2); kidney: 2.5 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197779,ZNF81,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.533333,-0.546271,-0.616866
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,29.8,23.2,13.7,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 2); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 2); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 2); lung: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 2); amygdala: 14.2 nTPM (vital, limit 1); smooth muscle: 13.7 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.1 nTPM (protected, limit 2); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 2); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); adrenal gland: 10.2 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pituitary gland: 8.8 nTPM (vital, limit 1); retina: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197798,FAM118B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.7987% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.0968% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.4286% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 47.4886% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.2000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.7879% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.9387% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 41.1067% (minimum 99%, Baseline (adaptation disabled)); colon: 47.2727% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.6082% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.7589% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.1667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.6086% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.8228% (minimum 99%, Baseline (adaptation disabled)); kidney: 67.5325% (minimum 99%, Baseline (adaptation disabled)); liver: 70.5085% (minimum 99%, Baseline (adaptation disabled)); lung: 56.9863% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.6506% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.0875% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.7589% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.2703% (minimum 99%, Baseline (adaptation disabled)); rectum: 47.5973% (minimum 97%, Baseline (adaptation disabled)); retina: 70.2703% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.7273% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 49.5238% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.0896% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.2899% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.0303% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.0968% (minimum 95%, Baseline (adaptation disabled)); stomach: 58.9235% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.2899% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 67.7524% (minimum 95%, Baseline (adaptation disabled)); tongue: 56.9863% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.3569% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,29.8,23.2,13.7,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 2); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 2); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 2); lung: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 2); amygdala: 14.2 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); smooth muscle: 13.7 nTPM (vital, limit 1); urinary bladder: 13.1 nTPM (protected, limit 2); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 2); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); adipose tissue: 9 nTPM (manageable, limit 5); pituitary gland: 8.8 nTPM (vital, limit 1); retina: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197798,FAM118B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.347101,-0.497273,-0.578933
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.7987% (minimum 90%, Approved); adrenal gland: 67.0968% (minimum 99%, Missing); amygdala: 59.4286% (minimum 99%, Missing); basal ganglia: 47.4886% (minimum 99%, Missing); bone marrow: 83.2000% (minimum 99%, Missing); cerebellum: 78.7879% (minimum 99%, Missing); cerebral cortex: 57.9387% (minimum 99%, Missing); choroid plexus: 41.1067% (minimum 99%, Missing); colon: 47.2727% (minimum 97%, Missing); duodenum: 53.6082% (minimum 99%, Missing); esophagus: 73.7589% (minimum 97%, Missing); heart muscle: 54.1667% (minimum 99%, Missing); hippocampal formation: 63.6086% (minimum 99%, Missing); hypothalamus: 65.8228% (minimum 99%, Missing); kidney: 67.5325% (minimum 99%, Missing); liver: 70.5085% (minimum 99%, Missing); lung: 56.9863% (minimum 99%, Missing); lymph node: 62.6506% (minimum 97%, Missing); midbrain: 64.0000% (minimum 99%, Missing); pancreas: 79.0875% (minimum 99%, Missing); parathyroid gland: 73.7589% (minimum 97%, Missing); pituitary gland: 70.2703% (minimum 99%, Missing); rectum: 47.5973% (minimum 97%, Missing); retina: 70.2703% (minimum 99%, Missing); salivary gland: 72.7273% (minimum 97%, Missing); skeletal muscle: 49.5238% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 62.0896% (minimum 99%, Missing); smooth muscle: 60.2899% (minimum 99%, Missing); spinal cord: 63.0303% (minimum 99%, Missing); spleen: 67.0968% (minimum 95%, Missing); stomach: 58.9235% (minimum 97%, Missing); thymus: 60.2899% (minimum 95%, Missing); thyroid gland: 67.7524% (minimum 95%, Missing); tongue: 56.9863% (minimum 97%, Missing); urinary bladder: 61.3569% (minimum 97%, Missing)",0,6,partial,29.8,23.2,13.7,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 2); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 2); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 2); lung: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 2); amygdala: 14.2 nTPM (vital, limit 1); smooth muscle: 13.7 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.1 nTPM (protected, limit 2); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 2); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); adrenal gland: 10.2 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pituitary gland: 8.8 nTPM (vital, limit 1); retina: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 2); parathyroid gland: 7.4 nTPM (protected, limit 2); esophagus: 7.4 nTPM (protected, limit 2); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197798,FAM118B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.347101,-0.497273,-0.578933
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,5.1,0.1,0.5,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,ENSG00000197826,CFAP299,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.9929% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.7241% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.3768% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.8848% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.9117% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.4762% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.1695% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8848% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.5185% (minimum 99%, Baseline (adaptation disabled)); retina: 97.4359% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.1550% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,5.1,0.1,0.5,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,ENSG00000197826,CFAP299,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0315498,0.0262547,-0.150883
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 93.9929% (minimum 99%, Missing); basal ganglia: 91.7241% (minimum 99%, Missing); cerebellum: 96.3768% (minimum 98%, Approved); choroid plexus: 83.9117% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 90.1695% (minimum 99%, Missing); lung: 95.0000% (minimum 98%, Approved); midbrain: 98.5185% (minimum 99%, Missing); retina: 97.4359% (minimum 99%, Missing); spinal cord: 98.1550% (minimum 99%, Missing)",0,6,partial,5.1,0.1,0.5,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,ENSG00000197826,CFAP299,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0462547,0.03,-0.150883
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000197849,OR8G1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 66.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000197849,OR8G1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.323333
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 66.6667% (minimum 99%, Missing); retina: 66.6667% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000197849,OR8G1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.323333
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,8.5,5.6,9.2,"skin: 9.2 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 2); lymph node: 5.3 nTPM (protected, limit 2); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); tongue: 4.8 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197863,ZNF790,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.8865% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.4805% (minimum 99%, Baseline (adaptation disabled)); amygdala: 74.3056% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.8252% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.5938% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.9784% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.3947% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.1529% (minimum 99%, Baseline (adaptation disabled)); colon: 78.1022% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.7931% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.8121% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.8750% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.4286% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.9784% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.2439% (minimum 99%, Baseline (adaptation disabled)); liver: 55.7292% (minimum 99%, Baseline (adaptation disabled)); lung: 74.8252% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.8750% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.3521% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.3333% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.6442% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.6765% (minimum 99%, Baseline (adaptation disabled)); rectum: 81.0606% (minimum 97%, Baseline (adaptation disabled)); retina: 57.8378% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.6765% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.0323% (minimum 99%, Baseline (adaptation disabled)); skin: 53.7688% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.8252% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.9784% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.1022% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.9346% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.4805% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.8121% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.8378% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.0323% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.3521% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,8.5,5.6,9.2,"skin: 9.2 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 2); lymph node: 5.3 nTPM (protected, limit 2); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); tongue: 4.8 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197863,ZNF790,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.412312,-0.313558,-0.432708
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 75.8865% (minimum 95%, Missing); adrenal gland: 69.4805% (minimum 99%, Missing); amygdala: 74.3056% (minimum 99%, Missing); basal ganglia: 74.8252% (minimum 99%, Missing); bone marrow: 83.5938% (minimum 99%, Missing); cerebellum: 76.9784% (minimum 99%, Missing); cerebral cortex: 70.3947% (minimum 99%, Missing); choroid plexus: 68.1529% (minimum 99%, Missing); colon: 78.1022% (minimum 97%, Missing); duodenum: 73.7931% (minimum 99%, Missing); esophagus: 71.8121% (minimum 97%, Uncertain); heart muscle: 66.8750% (minimum 99%, Uncertain); hippocampal formation: 76.4286% (minimum 99%, Missing); hypothalamus: 76.9784% (minimum 99%, Missing); kidney: 65.2439% (minimum 99%, Missing); liver: 55.7292% (minimum 99%, Missing); lung: 74.8252% (minimum 99%, Missing); lymph node: 66.8750% (minimum 97%, Missing); midbrain: 75.3521% (minimum 99%, Missing); pancreas: 71.3333% (minimum 99%, Missing); parathyroid gland: 65.6442% (minimum 97%, Uncertain); pituitary gland: 78.6765% (minimum 99%, Missing); rectum: 81.0606% (minimum 97%, Missing); retina: 57.8378% (minimum 99%, Missing); salivary gland: 78.6765% (minimum 97%, Missing); skeletal muscle: 69.0323% (minimum 99%, Missing); skin: 53.7688% (minimum 95%, Missing); small intestine: 74.8252% (minimum 99%, Missing); smooth muscle: 76.9784% (minimum 99%, Missing); spinal cord: 78.1022% (minimum 99%, Missing); spleen: 69.9346% (minimum 95%, Uncertain); stomach: 69.4805% (minimum 97%, Missing); thymus: 71.8121% (minimum 95%, Missing); thyroid gland: 57.8378% (minimum 95%, Missing); tongue: 69.0323% (minimum 97%, Missing); urinary bladder: 75.3521% (minimum 97%, Missing)",0,2,partial,8.5,5.6,9.2,"skin: 9.2 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 2); lymph node: 5.3 nTPM (protected, limit 2); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); tongue: 4.8 nTPM (protected, limit 2); skeletal muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 2); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 2); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); salivary gland: 2.9 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000197863,ZNF790,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.412312,-0.313558,-0.432708
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.2,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000197889,MEIG1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.0588% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.1165% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.3962% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.2857% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.8257% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.0588% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0198% (minimum 99%, Baseline (adaptation disabled)); lung: 96.1165% (minimum 99%, Baseline (adaptation disabled)); midbrain: 90.8257% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0198% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.5234% (minimum 99%, Baseline (adaptation disabled)); retina: 96.1165% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.3962% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.2,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000197889,MEIG1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.030198,0.010198,-0.09
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.0588% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 90.0000% (minimum 99%, Missing); cerebellum: 96.1165% (minimum 99%, Missing); cerebral cortex: 93.3962% (minimum 99%, Missing); choroid plexus: 94.2857% (minimum 99%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 90.8257% (minimum 99%, Missing); kidney: 97.0588% (minimum 99%, Missing); liver: 98.0198% (minimum 99%, Missing); lung: 96.1165% (minimum 99%, Missing); midbrain: 90.8257% (minimum 99%, Missing); pancreas: 98.0198% (minimum 99%, Missing); pituitary gland: 92.5234% (minimum 99%, Missing); retina: 96.1165% (minimum 99%, Missing); spinal cord: 93.3962% (minimum 99%, Missing)",0,80,unavailable,1.1,0.2,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000197889,MEIG1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.030198,0.010198,-0.09
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,11.3,9.3,11.5,"thyroid gland: 11.5 nTPM (manageable, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 2); thymus: 9 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); skin: 8.7 nTPM (manageable, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); salivary gland: 7.6 nTPM (protected, limit 2); urinary bladder: 7.5 nTPM (protected, limit 2); tongue: 6.9 nTPM (protected, limit 2); colon: 6.6 nTPM (protected, limit 2); kidney: 6.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 4); lung: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 2); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000197928,ZNF677,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.1740% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 87.7016% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.7722% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.5789% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.9571% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.8142% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.9609% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.1610% (minimum 99%, Baseline (adaptation disabled)); colon: 86.8263% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.7505% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.1393% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 79.8165% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.9662% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.3476% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.5252% (minimum 99%, Baseline (adaptation disabled)); liver: 94.1558% (minimum 99%, Baseline (adaptation disabled)); lung: 87.7016% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.5252% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.3476% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.3224% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 82.3864% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.2490% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.7722% (minimum 97%, Baseline (adaptation disabled)); retina: 79.3796% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 85.1272% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.5062% (minimum 99%, Baseline (adaptation disabled)); skin: 83.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.9487% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.4366% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.3224% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.8571% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 79.0909% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.3095% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 85.2941% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,11.3,9.3,11.5,"thyroid gland: 11.5 nTPM (manageable, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 2); thymus: 9 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); skin: 8.7 nTPM (manageable, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); salivary gland: 7.6 nTPM (protected, limit 2); urinary bladder: 7.5 nTPM (protected, limit 2); tongue: 6.9 nTPM (protected, limit 2); colon: 6.6 nTPM (protected, limit 2); kidney: 6.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 2); lung: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); stomach: 5.2 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000197928,ZNF677,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.159091,-0.146136,-0.196204
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.1740% (minimum 90%, Approved); adrenal gland: 87.7016% (minimum 99%, Missing); amygdala: 91.7722% (minimum 99%, Missing); basal ganglia: 91.5789% (minimum 99%, Missing); bone marrow: 88.9571% (minimum 99%, Missing); cerebellum: 90.8142% (minimum 99%, Missing); cerebral cortex: 84.9609% (minimum 99%, Missing); choroid plexus: 92.1610% (minimum 99%, Missing); colon: 86.8263% (minimum 97%, Missing); duodenum: 92.7505% (minimum 99%, Missing); esophagus: 89.1393% (minimum 97%, Missing); heart muscle: 79.8165% (minimum 99%, Missing); hippocampal formation: 91.9662% (minimum 99%, Missing); hypothalamus: 93.3476% (minimum 99%, Missing); kidney: 87.5252% (minimum 99%, Missing); liver: 94.1558% (minimum 99%, Missing); lung: 87.7016% (minimum 99%, Missing); lymph node: 87.5252% (minimum 95%, Approved); midbrain: 93.3476% (minimum 99%, Missing); pancreas: 89.3224% (minimum 99%, Missing); parathyroid gland: 82.3864% (minimum 97%, Missing); pituitary gland: 90.2490% (minimum 99%, Missing); rectum: 91.7722% (minimum 97%, Missing); retina: 79.3796% (minimum 99%, Missing); salivary gland: 85.1272% (minimum 97%, Missing); skeletal muscle: 89.5062% (minimum 99%, Missing); skin: 83.3333% (minimum 95%, Missing); small intestine: 92.9487% (minimum 99%, Missing); smooth muscle: 82.8571% (minimum 99%, Missing); spinal cord: 90.4366% (minimum 99%, Missing); spleen: 83.3333% (minimum 90%, Approved); stomach: 89.3224% (minimum 97%, Missing); thymus: 82.8571% (minimum 95%, Missing); thyroid gland: 79.0909% (minimum 95%, Missing); tongue: 86.3095% (minimum 97%, Missing); urinary bladder: 85.2941% (minimum 97%, Missing)",0,6,partial,11.3,9.3,11.5,"thyroid gland: 11.5 nTPM (manageable, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 2); thymus: 9 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); skin: 8.7 nTPM (manageable, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); salivary gland: 7.6 nTPM (protected, limit 2); urinary bladder: 7.5 nTPM (protected, limit 2); tongue: 6.9 nTPM (protected, limit 2); colon: 6.6 nTPM (protected, limit 2); kidney: 6.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 4); lung: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 2); pancreas: 5.2 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 2); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 2); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000197928,ZNF677,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.159091,-0.146136,-0.196204
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,2,partial,1,0.7,1.1,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000197935,ZNF311,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.7586% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.7586% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.3077% (minimum 99%, Baseline (adaptation disabled)); colon: 77.4194% (minimum 97%, Baseline (adaptation disabled)); esophagus: 80.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 85.7143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.5882% (minimum 99%, Baseline (adaptation disabled)); liver: 77.4194% (minimum 99%, Baseline (adaptation disabled)); lung: 88.8889% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 85.7143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.7586% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.3077% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 82.7586% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.7586% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 82.7586% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 68.5714% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 77.4194% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,1,0.7,1.1,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000197935,ZNF311,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.264286,-0.195806,-0.284118
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 82.7586% (minimum 90%, Approved); adrenal gland: 82.7586% (minimum 98%, Approved); amygdala: 85.7143% (minimum 99%, Missing); basal ganglia: 85.7143% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 99%, Missing); cerebral cortex: 92.3077% (minimum 99%, Missing); colon: 77.4194% (minimum 95%, Approved); esophagus: 80.0000% (minimum 95%, Approved); heart muscle: 88.8889% (minimum 98%, Approved); hippocampal formation: 85.7143% (minimum 99%, Missing); hypothalamus: 85.7143% (minimum 99%, Missing); kidney: 70.5882% (minimum 98%, Approved); liver: 77.4194% (minimum 98%, Approved); lung: 88.8889% (minimum 98%, Approved); midbrain: 85.7143% (minimum 99%, Missing); pancreas: 82.7586% (minimum 98%, Approved); pituitary gland: 88.8889% (minimum 99%, Missing); rectum: 92.3077% (minimum 95%, Approved); salivary gland: 80.0000% (minimum 95%, Approved); skeletal muscle: 96.0000% (minimum 98%, Approved); skin: 82.7586% (minimum 90%, Approved); small intestine: 82.7586% (minimum 98%, Approved); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 80.0000% (minimum 90%, Approved); stomach: 82.7586% (minimum 95%, Approved); thyroid gland: 68.5714% (minimum 90%, Approved); urinary bladder: 77.4194% (minimum 95%, Approved)",0,2,partial,1,0.7,1.1,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000197935,ZNF311,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.214286,-0.175806,-0.274118
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,50.9,9.4,1.7,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 2); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000197977,ELOVL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7077% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.7778% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.0193% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 85.4637% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.2458% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.4286% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.7670% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.5482% (minimum 99%, Baseline (adaptation disabled)); liver: 40.1176% (minimum 99%, Baseline (adaptation disabled)); midbrain: 81.3842% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.1694% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.3908% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.1622% (minimum 99%, Baseline (adaptation disabled)); retina: 55.8101% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.1510% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.9885% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.5688% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 94.4598% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,50.9,9.4,1.7,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 2); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000197977,ELOVL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.00251397,-0.186092,-0.588824
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7077% (minimum 99%, Missing); amygdala: 75.7778% (minimum 99%, Missing); basal ganglia: 73.0193% (minimum 99%, Missing); cerebellum: 85.4637% (minimum 99%, Missing); cerebral cortex: 72.2458% (minimum 99%, Missing); choroid plexus: 97.4286% (minimum 99%, Missing); heart muscle: 91.6667% (minimum 99%, Missing); hippocampal formation: 82.7670% (minimum 99%, Missing); hypothalamus: 86.5482% (minimum 99%, Missing); liver: 40.1176% (minimum 99%, Missing); midbrain: 81.3842% (minimum 99%, Missing); pancreas: 93.1694% (minimum 99%, Missing); parathyroid gland: 78.3908% (minimum 97%, Missing); pituitary gland: 92.1622% (minimum 99%, Missing); retina: 55.8101% (minimum 99%, Missing); skeletal muscle: 97.1510% (minimum 99%, Missing); smooth muscle: 97.9885% (minimum 99%, Missing); spinal cord: 62.5688% (minimum 99%, Missing); urinary bladder: 94.4598% (minimum 97%, Missing)",0,80,unavailable,50.9,9.4,1.7,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 2); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000197977,ELOVL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.00251397,-0.186092,-0.588824
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000198021,SPANXA1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000198021,SPANXA1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000198021,SPANXA1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2,0,0,"retina: 2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000198028,ZNF560,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 75.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2,0,0,"retina: 2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000198028,ZNF560,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,-0.24
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 75.0000% (minimum 99%, Missing)",0,80,unavailable,2,0,0,"retina: 2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000198028,ZNF560,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,-0.24
True,compatible,family_exclusion,True,True,False,,0,80,unavailable,0.2,0.5,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000198033,TUBA3C,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,family_exclusion,True,True,True,,0,80,unavailable,0.2,0.5,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000198033,TUBA3C,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.049746,0.0287313,0.00949213
True,compatible,family_exclusion,True,True,True,,0,80,unavailable,0.2,0.5,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000198033,TUBA3C,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.049746,0.0287313,0.00949213
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198062,POTEH,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198062,POTEH,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198062,POTEH,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,13.4,4,9.7,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 2); parathyroid gland: 4 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000198088,NUP62CL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.7756% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.1264% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.4134% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.4817% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2558% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 61.9048% (minimum 99%, Baseline (adaptation disabled)); colon: 86.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.3535% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.8571% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.3743% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.4802% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.8889% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.7788% (minimum 99%, Baseline (adaptation disabled)); liver: 90.3743% (minimum 99%, Baseline (adaptation disabled)); lung: 91.3514% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.3702% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.5714% (minimum 99%, Baseline (adaptation disabled)); pancreas: 80.0948% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.8612% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.1134% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 94.4134% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.4180% (minimum 97%, Baseline (adaptation disabled)); skin: 91.8478% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.3535% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.2558% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2558% (minimum 99%, Baseline (adaptation disabled)); stomach: 90.8602% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.4180% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 63.5338% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.9438% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,13.4,4,9.7,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000198088,NUP62CL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.314662,-0.161388,-0.432244
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.7756% (minimum 99%, Missing); amygdala: 97.1264% (minimum 99%, Missing); basal ganglia: 94.4134% (minimum 99%, Missing); bone marrow: 88.4817% (minimum 98%, Approved); choroid plexus: 61.9048% (minimum 99%, Missing); colon: 86.6667% (minimum 97%, Missing); duodenum: 85.3535% (minimum 99%, Missing); esophagus: 92.8571% (minimum 95%, Approved); heart muscle: 90.3743% (minimum 98%, Approved); hippocampal formation: 95.4802% (minimum 99%, Missing); hypothalamus: 93.8889% (minimum 99%, Missing); kidney: 74.7788% (minimum 99%, Missing); liver: 90.3743% (minimum 98%, Approved); lung: 91.3514% (minimum 99%, Missing); lymph node: 93.3702% (minimum 95%, Approved); midbrain: 96.5714% (minimum 99%, Missing); pancreas: 80.0948% (minimum 98%, Approved); parathyroid gland: 80.8612% (minimum 97%, Missing); pituitary gland: 87.1134% (minimum 99%, Missing); rectum: 84.5000% (minimum 97%, Missing); retina: 94.4134% (minimum 99%, Missing); salivary gland: 89.4180% (minimum 95%, Approved); small intestine: 85.3535% (minimum 99%, Missing); spinal cord: 98.2558% (minimum 99%, Missing); stomach: 90.8602% (minimum 97%, Missing); thymus: 89.4180% (minimum 95%, Missing); thyroid gland: 63.5338% (minimum 95%, Missing); urinary bladder: 94.9438% (minimum 97%, Missing)",0,2,partial,13.4,4,9.7,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 2); parathyroid gland: 4 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000198088,NUP62CL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.314662,-0.161388,-0.432244
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0,14.7,9,"esophagus: 14.7 nTPM (protected, limit 2); skin: 9 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000198092,TMPRSS11F,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 24.2268% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 82.4561% (minimum 97%, Baseline (adaptation disabled)); skin: 34.3066% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,14.7,9,"esophagus: 14.7 nTPM (protected, limit 2); skin: 9 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000198092,TMPRSS11F,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.606934,-0.727732,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 24.2268% (minimum 97%, Missing); salivary gland: 82.4561% (minimum 97%, Missing); skin: 34.3066% (minimum 95%, Missing)",0,80,unavailable,0,14.7,9,"esophagus: 14.7 nTPM (protected, limit 2); skin: 9 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,ENSG00000198092,TMPRSS11F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.606934,-0.727732,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000198129,DEFB107B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000198129,DEFB107B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000198129,DEFB107B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000198173,FAM47C,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 96.5517% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000198173,FAM47C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0244828
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 96.5517% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000198173,FAM47C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0244828
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,1.5,5.3,3.7,"lymph node: 5.3 nTPM (protected, limit 2); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198178,CLEC4C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.2500% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 46.4286% (minimum 99%, Baseline (adaptation disabled)); colon: 92.8571% (minimum 97%, Baseline (adaptation disabled)); esophagus: 86.6667% (minimum 97%, Baseline (adaptation disabled)); liver: 86.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 68.4211% (minimum 99%, Baseline (adaptation disabled)); lymph node: 19.6970% (minimum 97%, Baseline (adaptation disabled)); rectum: 92.8571% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); skin: 92.8571% (minimum 95%, Baseline (adaptation disabled)); small intestine: 86.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); spleen: 26.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 39.3939% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 56.5217% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,1.5,5.3,3.7,"lymph node: 5.3 nTPM (protected, limit 2); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198178,CLEC4C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.69,-0.77303,-0.525714
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 81.2500% (minimum 95%, Missing); bone marrow: 46.4286% (minimum 99%, Missing); colon: 92.8571% (minimum 97%, Missing); esophagus: 86.6667% (minimum 97%, Missing); liver: 86.6667% (minimum 99%, Missing); lung: 68.4211% (minimum 99%, Missing); lymph node: 19.6970% (minimum 97%, Missing); rectum: 92.8571% (minimum 97%, Missing); skeletal muscle: 92.8571% (minimum 99%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 86.6667% (minimum 99%, Missing); smooth muscle: 92.8571% (minimum 99%, Missing); spleen: 26.0000% (minimum 95%, Missing); stomach: 86.6667% (minimum 97%, Missing); thymus: 39.3939% (minimum 95%, Missing); urinary bladder: 56.5217% (minimum 97%, Missing)",0,3,partial,1.5,5.3,3.7,"lymph node: 5.3 nTPM (protected, limit 2); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198178,CLEC4C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.69,-0.77303,-0.525714
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.7,5,3.8,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 2); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); amygdala: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198182,ZNF607,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.0189% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.8621% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.2137% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.7273% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 94.6237% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.6897% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.4000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.1311% (minimum 99%, Baseline (adaptation disabled)); colon: 74.5763% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.6154% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.5763% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.8621% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.7273% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 81.4815% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.8761% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 76.5217% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 63.7681% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.4113% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.2430% (minimum 97%, Baseline (adaptation disabled)); retina: 65.6716% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.2793% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.0189% (minimum 99%, Baseline (adaptation disabled)); skin: 73.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.1930% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.9677% (minimum 99%, Baseline (adaptation disabled)); spleen: 74.5763% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.5714% (minimum 97%, Baseline (adaptation disabled)); thymus: 77.1930% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 69.8413% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.0189% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.2137% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.7,5,3.8,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 2); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); amygdala: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198182,ZNF607,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.251587,-0.332319,-0.383103
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 83.0189% (minimum 95%, Missing); adrenal gland: 75.8621% (minimum 99%, Missing); amygdala: 75.2137% (minimum 99%, Missing); basal ganglia: 72.7273% (minimum 99%, Missing); bone marrow: 94.6237% (minimum 99%, Missing); cerebellum: 60.6897% (minimum 99%, Missing); cerebral cortex: 70.4000% (minimum 99%, Missing); choroid plexus: 72.1311% (minimum 99%, Missing); colon: 74.5763% (minimum 97%, Missing); duodenum: 84.6154% (minimum 99%, Missing); esophagus: 74.5763% (minimum 97%, Missing); heart muscle: 75.8621% (minimum 99%, Missing); hippocampal formation: 73.3333% (minimum 99%, Missing); hypothalamus: 72.7273% (minimum 99%, Missing); kidney: 73.3333% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 81.4815% (minimum 99%, Missing); lymph node: 77.8761% (minimum 97%, Missing); midbrain: 73.3333% (minimum 99%, Missing); pancreas: 76.5217% (minimum 99%, Missing); parathyroid gland: 63.7681% (minimum 97%, Missing); pituitary gland: 62.4113% (minimum 99%, Missing); rectum: 82.2430% (minimum 97%, Missing); retina: 65.6716% (minimum 99%, Missing); salivary gland: 79.2793% (minimum 97%, Missing); skeletal muscle: 83.0189% (minimum 99%, Missing); skin: 73.3333% (minimum 95%, Missing); small intestine: 77.1930% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spinal cord: 70.9677% (minimum 99%, Missing); spleen: 74.5763% (minimum 95%, Missing); stomach: 78.5714% (minimum 97%, Missing); thymus: 77.1930% (minimum 95%, Missing); thyroid gland: 69.8413% (minimum 95%, Missing); tongue: 83.0189% (minimum 97%, Missing); urinary bladder: 75.2137% (minimum 97%, Missing)",0,80,unavailable,5.7,5,3.8,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 2); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); esophagus: 3 nTPM (protected, limit 2); urinary bladder: 2.9 nTPM (protected, limit 2); amygdala: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lymph node: 2.5 nTPM (protected, limit 2); stomach: 2.4 nTPM (protected, limit 2); salivary gland: 2.3 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198182,ZNF607,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.251587,-0.332319,-0.383103
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,17.7,3.6,0.7,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1)",nasopharynx / respiratory epithelial cells: Medium (Supported),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,ENSG00000198183,BPIFA1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lung: 25.3165% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 33.7079% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.5000% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.5522% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 86.9565% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,17.7,3.6,0.7,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 2)",nasopharynx / respiratory epithelial cells: Medium (Supported),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,ENSG00000198183,BPIFA1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0544776,-0.345,-0.736835
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lung: 25.3165% (minimum 99%, Missing); pituitary gland: 33.7079% (minimum 99%, Missing); salivary gland: 62.5000% (minimum 90%, Supported); thymus: 89.5522% (minimum 95%, Missing); urinary bladder: 86.9565% (minimum 90%, Supported)",0,2,partial,17.7,3.6,0.7,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1)",nasopharynx / respiratory epithelial cells: Medium (Supported),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,ENSG00000198183,BPIFA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0544776,-0.275,-0.736835
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,3,2.9,3.1,"skeletal muscle: 3 nTPM (vital, limit 1); tongue: 2.9 nTPM (protected, limit 2); bone marrow: 2.8 nTPM (vital, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000198205,ZXDA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.8148% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.3953% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.5556% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.9167% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 59.3220% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.7436% (minimum 99%, Baseline (adaptation disabled)); colon: 67.3077% (minimum 97%, Baseline (adaptation disabled)); duodenum: 72.9167% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.9167% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.3953% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.6364% (minimum 99%, Baseline (adaptation disabled)); liver: 67.3077% (minimum 99%, Baseline (adaptation disabled)); lung: 66.0377% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.6875% (minimum 97%, Baseline (adaptation disabled)); midbrain: 83.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.3448% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.3770% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.0870% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 67.3077% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.6275% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 53.8462% (minimum 99%, Baseline (adaptation disabled)); skin: 68.6275% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.9167% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 79.5455% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.0303% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.3220% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.4035% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.6875% (minimum 95%, Baseline (adaptation disabled)); tongue: 54.6875% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.3077% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,3,2.9,3.1,"skeletal muscle: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); tongue: 2.9 nTPM (protected, limit 2); bone marrow: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000198205,ZXDA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.419697,-0.423125,-0.451538
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 90%, Approved); adrenal gland: 64.8148% (minimum 98%, Approved); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 81.3953% (minimum 99%, Missing); bone marrow: 55.5556% (minimum 98%, Approved); cerebellum: 72.9167% (minimum 99%, Missing); cerebral cortex: 59.3220% (minimum 99%, Missing); choroid plexus: 89.7436% (minimum 99%, Missing); colon: 67.3077% (minimum 97%, Missing); duodenum: 72.9167% (minimum 99%, Missing); esophagus: 72.9167% (minimum 95%, Approved); heart muscle: 62.5000% (minimum 99%, Missing); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 81.3953% (minimum 99%, Missing); kidney: 63.6364% (minimum 99%, Missing); liver: 67.3077% (minimum 99%, Missing); lung: 66.0377% (minimum 98%, Approved); lymph node: 54.6875% (minimum 95%, Approved); midbrain: 83.3333% (minimum 99%, Missing); pancreas: 60.3448% (minimum 99%, Missing); parathyroid gland: 57.3770% (minimum 97%, Missing); pituitary gland: 76.0870% (minimum 99%, Missing); rectum: 70.0000% (minimum 97%, Missing); retina: 67.3077% (minimum 99%, Missing); salivary gland: 68.6275% (minimum 97%, Missing); skeletal muscle: 53.8462% (minimum 99%, Missing); skin: 68.6275% (minimum 90%, Approved); small intestine: 72.9167% (minimum 99%, Missing); smooth muscle: 62.5000% (minimum 98%, Approved); spinal cord: 79.5455% (minimum 99%, Missing); spleen: 53.0303% (minimum 90%, Approved); stomach: 59.3220% (minimum 97%, Missing); thymus: 61.4035% (minimum 95%, Missing); thyroid gland: 54.6875% (minimum 95%, Missing); tongue: 54.6875% (minimum 97%, Missing); urinary bladder: 67.3077% (minimum 97%, Missing)",0,5,partial,3,2.9,3.1,"skeletal muscle: 3 nTPM (vital, limit 1); tongue: 2.9 nTPM (protected, limit 2); bone marrow: 2.8 nTPM (vital, limit 2); parathyroid gland: 2.6 nTPM (protected, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); stomach: 2.4 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000198205,ZXDA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.403125,-0.423125,-0.451538
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198283,OR5B21,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198283,OR5B21,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198283,OR5B21,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4,3.1,3.2,"pancreas: 4 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198298,ZNF485,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 74.5098% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.3704% (minimum 99%, Baseline (adaptation disabled)); amygdala: 76.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.5098% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 86.3636% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 71.6981% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.5098% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 82.6087% (minimum 99%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.3704% (minimum 99%, Baseline (adaptation disabled)); esophagus: 67.8571% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.5098% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 74.5098% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.5172% (minimum 99%, Baseline (adaptation disabled)); liver: 69.0909% (minimum 99%, Baseline (adaptation disabled)); lung: 76.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.0725% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.0769% (minimum 99%, Baseline (adaptation disabled)); pancreas: 48.7179% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.0769% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.8511% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.8571% (minimum 97%, Baseline (adaptation disabled)); retina: 77.5510% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.0909% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.8824% (minimum 99%, Baseline (adaptation disabled)); skin: 54.2857% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.6981% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.0769% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.0769% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.4068% (minimum 95%, Baseline (adaptation disabled)); stomach: 63.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 69.0909% (minimum 95%, Baseline (adaptation disabled)); tongue: 61.2903% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 70.3704% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4,3.1,3.2,"pancreas: 4 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198298,ZNF485,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.407143,-0.419275,-0.502821
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 74.5098% (minimum 95%, Missing); adrenal gland: 70.3704% (minimum 99%, Missing); amygdala: 76.0000% (minimum 99%, Missing); basal ganglia: 74.5098% (minimum 99%, Missing); bone marrow: 86.3636% (minimum 99%, Missing); cerebellum: 71.6981% (minimum 99%, Missing); cerebral cortex: 74.5098% (minimum 99%, Missing); choroid plexus: 82.6087% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 70.3704% (minimum 99%, Missing); esophagus: 67.8571% (minimum 97%, Missing); heart muscle: 74.5098% (minimum 99%, Missing); hippocampal formation: 74.5098% (minimum 99%, Missing); hypothalamus: 76.0000% (minimum 99%, Missing); kidney: 65.5172% (minimum 99%, Missing); liver: 69.0909% (minimum 99%, Missing); lung: 76.0000% (minimum 99%, Missing); lymph node: 55.0725% (minimum 97%, Missing); midbrain: 73.0769% (minimum 99%, Missing); pancreas: 48.7179% (minimum 99%, Missing); parathyroid gland: 73.0769% (minimum 97%, Missing); pituitary gland: 80.8511% (minimum 99%, Missing); rectum: 67.8571% (minimum 97%, Missing); retina: 77.5510% (minimum 99%, Missing); salivary gland: 69.0909% (minimum 97%, Missing); skeletal muscle: 55.8824% (minimum 99%, Missing); skin: 54.2857% (minimum 95%, Missing); small intestine: 71.6981% (minimum 99%, Missing); smooth muscle: 73.0769% (minimum 99%, Missing); spinal cord: 73.0769% (minimum 99%, Missing); spleen: 64.4068% (minimum 95%, Missing); stomach: 63.3333% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 69.0909% (minimum 95%, Missing); tongue: 61.2903% (minimum 97%, Missing); urinary bladder: 70.3704% (minimum 97%, Missing)",0,80,unavailable,4,3.1,3.2,"pancreas: 4 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 2); skeletal muscle: 3 nTPM (vital, limit 1); tongue: 2.4 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198298,ZNF485,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.407143,-0.419275,-0.502821
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000198326,TMEM239,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000198326,TMEM239,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.00232246
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000198326,TMEM239,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.00232246
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,2.3,2.1,"parathyroid gland: 2.3 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198346,ZNF813,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.6610% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.4561% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.1569% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.3846% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 78.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.9167% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 87.0370% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.1569% (minimum 99%, Baseline (adaptation disabled)); colon: 73.4375% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.4375% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.0345% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.6792% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.1569% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.1569% (minimum 99%, Baseline (adaptation disabled)); kidney: 79.6610% (minimum 99%, Baseline (adaptation disabled)); liver: 88.6792% (minimum 99%, Baseline (adaptation disabled)); lung: 78.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 69.1176% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.3846% (minimum 99%, Baseline (adaptation disabled)); pancreas: 79.6610% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 67.1429% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.6792% (minimum 99%, Baseline (adaptation disabled)); rectum: 73.4375% (minimum 97%, Baseline (adaptation disabled)); retina: 88.6792% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.6610% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 71.2121% (minimum 95%, Baseline (adaptation disabled)); small intestine: 74.6032% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.9286% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 88.6792% (minimum 99%, Baseline (adaptation disabled)); spleen: 72.3077% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.2121% (minimum 97%, Baseline (adaptation disabled)); thymus: 69.1176% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 72.3077% (minimum 95%, Baseline (adaptation disabled)); tongue: 90.3846% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.7,2.3,2.1,"parathyroid gland: 2.3 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198346,ZNF813,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.258824,-0.298571,-0.255625
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 79.6610% (minimum 95%, Missing); adrenal gland: 82.4561% (minimum 99%, Missing); amygdala: 92.1569% (minimum 99%, Missing); basal ganglia: 90.3846% (minimum 99%, Missing); bone marrow: 78.3333% (minimum 99%, Missing); cerebellum: 97.9167% (minimum 99%, Missing); cerebral cortex: 87.0370% (minimum 99%, Missing); choroid plexus: 92.1569% (minimum 99%, Missing); colon: 73.4375% (minimum 97%, Missing); duodenum: 73.4375% (minimum 99%, Missing); esophagus: 81.0345% (minimum 97%, Missing); heart muscle: 88.6792% (minimum 99%, Missing); hippocampal formation: 92.1569% (minimum 99%, Missing); hypothalamus: 92.1569% (minimum 99%, Missing); kidney: 79.6610% (minimum 99%, Missing); liver: 88.6792% (minimum 99%, Missing); lung: 78.3333% (minimum 99%, Missing); lymph node: 69.1176% (minimum 97%, Missing); midbrain: 90.3846% (minimum 99%, Missing); pancreas: 79.6610% (minimum 99%, Missing); parathyroid gland: 67.1429% (minimum 97%, Missing); pituitary gland: 88.6792% (minimum 99%, Missing); rectum: 73.4375% (minimum 97%, Missing); retina: 88.6792% (minimum 99%, Missing); salivary gland: 79.6610% (minimum 97%, Missing); skeletal muscle: 94.0000% (minimum 99%, Missing); skin: 71.2121% (minimum 95%, Missing); small intestine: 74.6032% (minimum 99%, Missing); smooth muscle: 83.9286% (minimum 99%, Missing); spinal cord: 88.6792% (minimum 99%, Missing); spleen: 72.3077% (minimum 95%, Missing); stomach: 71.2121% (minimum 97%, Missing); thymus: 69.1176% (minimum 95%, Missing); thyroid gland: 72.3077% (minimum 95%, Missing); tongue: 90.3846% (minimum 97%, Missing); urinary bladder: 78.3333% (minimum 97%, Missing)",0,80,unavailable,1.7,2.3,2.1,"parathyroid gland: 2.3 nTPM (protected, limit 2); lymph node: 2.1 nTPM (protected, limit 2); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198346,ZNF813,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.258824,-0.298571,-0.255625
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000198390,KRTAP13-1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); skin: 2.2472% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000198390,KRTAP13-1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.927528,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 66.6667% (minimum 95%, Missing); skin: 2.2472% (minimum 95%, Missing)",0,80,unavailable,0,0,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000198390,KRTAP13-1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.927528,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4,3.9,3.3,"cerebellum: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198440,ZNF583,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.6078% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.5319% (minimum 99%, Baseline (adaptation disabled)); amygdala: 69.6078% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.2970% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 87.6543% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 63.9640% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.7407% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.6092% (minimum 99%, Baseline (adaptation disabled)); colon: 77.1739% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.5238% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.5294% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 78.0220% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.9320% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.2970% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.4490% (minimum 99%, Baseline (adaptation disabled)); liver: 73.9583% (minimum 99%, Baseline (adaptation disabled)); lung: 72.4490% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.6818% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.9320% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.9583% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.5455% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.1959% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.5294% (minimum 97%, Baseline (adaptation disabled)); retina: 64.5455% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.7500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.1739% (minimum 99%, Baseline (adaptation disabled)); skin: 89.8734% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.5422% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.9583% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.6190% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.5319% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.6092% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.4490% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.2692% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.6078% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.0220% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4,3.9,3.3,"cerebellum: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198440,ZNF583,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.267308,-0.324545,-0.35036
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.6078% (minimum 95%, Missing); adrenal gland: 75.5319% (minimum 99%, Missing); amygdala: 69.6078% (minimum 99%, Missing); basal ganglia: 70.2970% (minimum 99%, Missing); bone marrow: 87.6543% (minimum 99%, Missing); cerebellum: 63.9640% (minimum 99%, Missing); cerebral cortex: 65.7407% (minimum 99%, Missing); choroid plexus: 81.6092% (minimum 99%, Missing); colon: 77.1739% (minimum 97%, Missing); duodenum: 84.5238% (minimum 99%, Missing); esophagus: 83.5294% (minimum 97%, Missing); heart muscle: 78.0220% (minimum 99%, Missing); hippocampal formation: 68.9320% (minimum 99%, Missing); hypothalamus: 70.2970% (minimum 99%, Missing); kidney: 72.4490% (minimum 99%, Missing); liver: 73.9583% (minimum 99%, Missing); lung: 72.4490% (minimum 99%, Missing); lymph node: 80.6818% (minimum 97%, Missing); midbrain: 68.9320% (minimum 99%, Missing); pancreas: 73.9583% (minimum 99%, Missing); parathyroid gland: 64.5455% (minimum 97%, Missing); pituitary gland: 73.1959% (minimum 99%, Missing); rectum: 83.5294% (minimum 97%, Missing); retina: 64.5455% (minimum 99%, Missing); salivary gland: 88.7500% (minimum 97%, Missing); skeletal muscle: 77.1739% (minimum 99%, Missing); skin: 89.8734% (minimum 95%, Missing); small intestine: 85.5422% (minimum 99%, Missing); smooth muscle: 73.9583% (minimum 99%, Missing); spinal cord: 67.6190% (minimum 99%, Missing); spleen: 75.5319% (minimum 95%, Missing); stomach: 81.6092% (minimum 97%, Missing); thymus: 72.4490% (minimum 95%, Missing); thyroid gland: 68.2692% (minimum 95%, Missing); tongue: 69.6078% (minimum 97%, Missing); urinary bladder: 78.0220% (minimum 97%, Missing)",0,80,unavailable,4,3.9,3.3,"cerebellum: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 2); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 2); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198440,ZNF583,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.267308,-0.324545,-0.35036
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198445,CCT8L2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198445,CCT8L2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198445,CCT8L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.4,5.9,5.3,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198453,ZNF568,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7363% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 56.8627% (minimum 99%, Baseline (adaptation disabled)); amygdala: 54.2056% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 75.3247% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 49.5726% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 57.4257% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.7363% (minimum 99%, Baseline (adaptation disabled)); colon: 62.3656% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.4521% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.8795% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 65.9091% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.7692% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 51.7857% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.1685% (minimum 99%, Baseline (adaptation disabled)); liver: 73.4177% (minimum 99%, Baseline (adaptation disabled)); lung: 69.0476% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 52.7273% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.9091% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.5726% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.3158% (minimum 97%, Baseline (adaptation disabled)); retina: 40.8451% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 62.3656% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 41.7266% (minimum 99%, Baseline (adaptation disabled)); skin: 63.0435% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.6049% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.4257% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 58.5859% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.4419% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.4444% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.2523% (minimum 95%, Baseline (adaptation disabled)); tongue: 57.4257% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.7021% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8.4,5.9,5.3,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198453,ZNF568,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.427477,-0.474274,-0.581549
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7363% (minimum 95%, Missing); adrenal gland: 56.8627% (minimum 99%, Missing); amygdala: 54.2056% (minimum 99%, Missing); basal ganglia: 58.0000% (minimum 99%, Missing); bone marrow: 75.3247% (minimum 99%, Missing); cerebellum: 49.5726% (minimum 99%, Missing); cerebral cortex: 57.4257% (minimum 99%, Missing); choroid plexus: 63.7363% (minimum 99%, Missing); colon: 62.3656% (minimum 97%, Missing); duodenum: 79.4521% (minimum 99%, Missing); esophagus: 69.8795% (minimum 97%, Missing); heart muscle: 65.9091% (minimum 99%, Missing); hippocampal formation: 55.7692% (minimum 99%, Missing); hypothalamus: 51.7857% (minimum 99%, Missing); kidney: 65.1685% (minimum 99%, Missing); liver: 73.4177% (minimum 99%, Missing); lung: 69.0476% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 52.7273% (minimum 99%, Missing); pancreas: 65.9091% (minimum 99%, Missing); parathyroid gland: 49.5726% (minimum 97%, Missing); pituitary gland: 58.0000% (minimum 99%, Missing); rectum: 76.3158% (minimum 97%, Missing); retina: 40.8451% (minimum 99%, Missing); salivary gland: 62.3656% (minimum 97%, Missing); skeletal muscle: 41.7266% (minimum 99%, Missing); skin: 63.0435% (minimum 95%, Missing); small intestine: 71.6049% (minimum 99%, Missing); smooth muscle: 57.4257% (minimum 99%, Missing); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 58.5859% (minimum 95%, Missing); stomach: 67.4419% (minimum 97%, Missing); thymus: 64.4444% (minimum 95%, Missing); thyroid gland: 52.2523% (minimum 95%, Missing); tongue: 57.4257% (minimum 97%, Missing); urinary bladder: 61.7021% (minimum 97%, Missing)",0,80,unavailable,8.4,5.9,5.3,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 2); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 2); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 2); salivary gland: 3.5 nTPM (protected, limit 2); colon: 3.5 nTPM (protected, limit 2); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); stomach: 2.8 nTPM (protected, limit 2); lung: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198453,ZNF568,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.427477,-0.474274,-0.581549
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,11.2,12.7,7.5,"rectum: 12.7 nTPM (protected, limit 2); salivary gland: 11.7 nTPM (protected, limit 2); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); esophagus: 6 nTPM (protected, limit 2); spleen: 6 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); parathyroid gland: 4.8 nTPM (protected, limit 2); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000198466,ZNF587,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.8966% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.9864% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.9323% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.5405% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 59.1463% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 58.7879% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 69.2857% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.8029% (minimum 99%, Baseline (adaptation disabled)); colon: 53.8889% (minimum 97%, Baseline (adaptation disabled)); duodenum: 54.8023% (minimum 99%, Baseline (adaptation disabled)); esophagus: 61.7834% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.5806% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 69.7842% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.3099% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.6250% (minimum 99%, Baseline (adaptation disabled)); liver: 61.3924% (minimum 99%, Baseline (adaptation disabled)); lung: 61.7834% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 75.1938% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.4324% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.8966% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 46.4115% (minimum 99%, Baseline (adaptation disabled)); rectum: 43.3036% (minimum 97%, Baseline (adaptation disabled)); retina: 46.4115% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 45.3271% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 69.2857% (minimum 99%, Baseline (adaptation disabled)); skin: 62.5806% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.7471% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.2857% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.7834% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.7174% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.3953% (minimum 95%, Baseline (adaptation disabled)); tongue: 70.8029% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.7834% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,11.2,12.7,7.5,"rectum: 12.7 nTPM (protected, limit 2); salivary gland: 11.7 nTPM (protected, limit 2); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); esophagus: 6 nTPM (protected, limit 2); spleen: 6 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); parathyroid gland: 4.8 nTPM (protected, limit 2); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000198466,ZNF587,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.386047,-0.536964,-0.525885
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 66.8966% (minimum 95%, Missing); adrenal gland: 65.9864% (minimum 99%, Missing); amygdala: 72.9323% (minimum 99%, Missing); basal ganglia: 65.5405% (minimum 99%, Missing); bone marrow: 59.1463% (minimum 99%, Missing); cerebellum: 58.7879% (minimum 99%, Missing); cerebral cortex: 69.2857% (minimum 99%, Missing); choroid plexus: 70.8029% (minimum 99%, Missing); colon: 53.8889% (minimum 97%, Missing); duodenum: 54.8023% (minimum 99%, Missing); esophagus: 61.7834% (minimum 97%, Missing); heart muscle: 62.5806% (minimum 99%, Missing); hippocampal formation: 69.7842% (minimum 99%, Missing); hypothalamus: 68.3099% (minimum 99%, Missing); kidney: 60.6250% (minimum 99%, Missing); liver: 61.3924% (minimum 99%, Missing); lung: 61.7834% (minimum 99%, Missing); lymph node: 64.6667% (minimum 97%, Uncertain); midbrain: 75.1938% (minimum 99%, Missing); pancreas: 52.4324% (minimum 99%, Missing); parathyroid gland: 66.8966% (minimum 97%, Missing); pituitary gland: 46.4115% (minimum 99%, Missing); rectum: 43.3036% (minimum 97%, Missing); retina: 46.4115% (minimum 99%, Missing); salivary gland: 45.3271% (minimum 97%, Missing); skeletal muscle: 69.2857% (minimum 99%, Missing); skin: 62.5806% (minimum 95%, Missing); small intestine: 55.7471% (minimum 99%, Missing); smooth muscle: 64.6667% (minimum 99%, Missing); spinal cord: 69.2857% (minimum 99%, Missing); spleen: 61.7834% (minimum 95%, Uncertain); stomach: 52.7174% (minimum 97%, Missing); thymus: 64.6667% (minimum 95%, Missing); thyroid gland: 56.3953% (minimum 95%, Missing); tongue: 70.8029% (minimum 97%, Missing); urinary bladder: 61.7834% (minimum 97%, Missing)",0,3,partial,11.2,12.7,7.5,"rectum: 12.7 nTPM (protected, limit 2); salivary gland: 11.7 nTPM (protected, limit 2); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 2); colon: 8.3 nTPM (protected, limit 2); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 2); esophagus: 6 nTPM (protected, limit 2); spleen: 6 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 2); smooth muscle: 5.3 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); parathyroid gland: 4.8 nTPM (protected, limit 2); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 2); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000198466,ZNF587,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.386047,-0.536964,-0.525885
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.9,0,0,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000198471,RTP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 38.7097% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.9,0,0,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000198471,RTP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,0.03,-0.602903
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 38.7097% (minimum 99%, Missing)",0,80,unavailable,1.9,0,0,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000198471,RTP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,0.03,-0.602903
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.7,8.1,9.8,"bone marrow: 10.7 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.5 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 2); skin: 7.2 nTPM (manageable, limit 5); retina: 6.7 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); parathyroid gland: 6.4 nTPM (protected, limit 2); cerebral cortex: 5.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 2); kidney: 4.9 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); heart muscle: 4.8 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198521,ZNF43,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.0588% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 71.5328% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.4000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.3279% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 47.8049% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.5926% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.8205% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.9649% (minimum 99%, Baseline (adaptation disabled)); colon: 69.5035% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.5328% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.6842% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.1233% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.4000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.1654% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 85.9649% (minimum 99%, Baseline (adaptation disabled)); lung: 70.5036% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.7486% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.7778% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.1654% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.4938% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 79.6748% (minimum 99%, Baseline (adaptation disabled)); rectum: 65.7718% (minimum 97%, Baseline (adaptation disabled)); retina: 59.3939% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 73.6842% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 70.5036% (minimum 99%, Baseline (adaptation disabled)); skin: 57.6471% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 69.5035% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.8092% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.1227% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.1233% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.5519% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.5862% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.6842% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.7,8.1,9.8,"bone marrow: 10.7 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.5 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 2); skin: 7.2 nTPM (manageable, limit 5); retina: 6.7 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); parathyroid gland: 6.4 nTPM (protected, limit 2); cerebral cortex: 5.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 2); kidney: 4.9 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); heart muscle: 4.8 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198521,ZNF43,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.422514,-0.511951
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.0588% (minimum 95%, Missing); adrenal gland: 71.5328% (minimum 99%, Missing); amygdala: 78.4000% (minimum 99%, Missing); basal ganglia: 80.3279% (minimum 99%, Missing); bone marrow: 47.8049% (minimum 99%, Missing); cerebellum: 72.5926% (minimum 99%, Missing); cerebral cortex: 62.8205% (minimum 99%, Missing); choroid plexus: 85.9649% (minimum 99%, Missing); colon: 69.5035% (minimum 97%, Missing); duodenum: 71.5328% (minimum 99%, Missing); esophagus: 73.6842% (minimum 97%, Missing); heart muscle: 67.1233% (minimum 99%, Missing); hippocampal formation: 78.4000% (minimum 99%, Missing); hypothalamus: 77.1654% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); liver: 85.9649% (minimum 99%, Missing); lung: 70.5036% (minimum 99%, Missing); lymph node: 54.7486% (minimum 97%, Missing); midbrain: 77.7778% (minimum 99%, Missing); pancreas: 77.1654% (minimum 99%, Missing); parathyroid gland: 60.4938% (minimum 97%, Missing); pituitary gland: 79.6748% (minimum 99%, Missing); rectum: 65.7718% (minimum 97%, Missing); retina: 59.3939% (minimum 99%, Missing); salivary gland: 73.6842% (minimum 97%, Missing); skeletal muscle: 70.5036% (minimum 99%, Missing); skin: 57.6471% (minimum 95%, Missing); small intestine: 70.0000% (minimum 99%, Missing); smooth muscle: 69.5035% (minimum 99%, Missing); spinal cord: 74.8092% (minimum 99%, Missing); spleen: 60.1227% (minimum 95%, Missing); stomach: 67.1233% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing); thyroid gland: 53.5519% (minimum 95%, Missing); tongue: 67.5862% (minimum 97%, Missing); urinary bladder: 73.6842% (minimum 97%, Missing)",0,80,unavailable,10.7,8.1,9.8,"bone marrow: 10.7 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.5 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 2); skin: 7.2 nTPM (manageable, limit 5); retina: 6.7 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); parathyroid gland: 6.4 nTPM (protected, limit 2); cerebral cortex: 5.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 2); kidney: 4.9 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 2); heart muscle: 4.8 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 2); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 2); small intestine: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 2); urinary bladder: 3.5 nTPM (protected, limit 2); esophagus: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198521,ZNF43,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.422514,-0.511951
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,7.1,5.4,7.8,"thymus: 7.8 nTPM (manageable, limit 5); bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); esophagus: 2.4 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198554,WDHD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 80.9524% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 86.4407% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.0714% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 41.8033% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 83.6066% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.6875% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.4444% (minimum 99%, Baseline (adaptation disabled)); colon: 65.3846% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.9130% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.4407% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.4737% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.7273% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.6066% (minimum 99%, Baseline (adaptation disabled)); liver: 82.2581% (minimum 99%, Baseline (adaptation disabled)); lung: 79.6875% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.5714% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.7273% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 78.4615% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.4444% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.9310% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.4737% (minimum 99%, Baseline (adaptation disabled)); skin: 71.8310% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.1194% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.1053% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.0714% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.2727% (minimum 97%, Baseline (adaptation disabled)); thymus: 39.5349% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.4407% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.1194% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,7.1,5.4,7.8,"thymus: 7.8 nTPM (manageable, limit 5); bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); smooth muscle: 2.5 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198554,WDHD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.554651,-0.484286,-0.571967
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 86.4407% (minimum 95%, Enhanced); amygdala: 91.0714% (minimum 99%, Missing); basal ganglia: 85.0000% (minimum 99%, Missing); bone marrow: 41.8033% (minimum 99%, Missing); cerebellum: 83.6066% (minimum 95%, Enhanced); cerebral cortex: 79.6875% (minimum 95%, Enhanced); choroid plexus: 94.4444% (minimum 99%, Missing); colon: 65.3846% (minimum 97%, Missing); duodenum: 73.9130% (minimum 99%, Missing); esophagus: 68.0000% (minimum 97%, Missing); heart muscle: 86.4407% (minimum 95%, Enhanced); hippocampal formation: 89.4737% (minimum 99%, Missing); hypothalamus: 92.7273% (minimum 99%, Missing); kidney: 83.6066% (minimum 99%, Missing); liver: 82.2581% (minimum 95%, Enhanced); lung: 79.6875% (minimum 99%, Missing); lymph node: 48.5714% (minimum 97%, Missing); midbrain: 92.7273% (minimum 99%, Missing); pancreas: 85.0000% (minimum 99%, Missing); parathyroid gland: 78.4615% (minimum 97%, Missing); pituitary gland: 94.4444% (minimum 99%, Missing); rectum: 56.6667% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); salivary gland: 87.9310% (minimum 97%, Missing); skeletal muscle: 89.4737% (minimum 95%, Enhanced); skin: 71.8310% (minimum 95%, Missing); small intestine: 76.1194% (minimum 99%, Missing); smooth muscle: 67.1053% (minimum 95%, Enhanced); spinal cord: 91.0714% (minimum 99%, Missing); spleen: 75.0000% (minimum 95%, Missing); stomach: 77.2727% (minimum 97%, Missing); thymus: 39.5349% (minimum 95%, Missing); tongue: 86.4407% (minimum 97%, Missing); urinary bladder: 76.1194% (minimum 97%, Missing)",0,7,partial,7.1,5.4,7.8,"thymus: 7.8 nTPM (manageable, limit 5); bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 2); rectum: 3.9 nTPM (protected, limit 2); colon: 2.7 nTPM (protected, limit 2); esophagus: 2.4 nTPM (protected, limit 2); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198554,WDHD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.554651,-0.484286,-0.571967
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000198573,SPANXC,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000198573,SPANXC,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000198573,SPANXC,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,15.7,17.5,17.1,"parathyroid gland: 17.5 nTPM (protected, limit 2); thyroid gland: 17.1 nTPM (manageable, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 2); liver: 14.3 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 2); cerebral cortex: 13 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); colon: 12.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 2); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 2); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); salivary gland: 8.9 nTPM (protected, limit 2); skin: 8.3 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198586,TLK1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.7959% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 61.7329% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.8676% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.0714% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.7069% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.8106% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.4000% (minimum 99%, Baseline (adaptation disabled)); colon: 57.5758% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.0190% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.5172% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.8487% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 62.4088% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.2857% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.7703% (minimum 99%, Baseline (adaptation disabled)); liver: 54.4586% (minimum 99%, Baseline (adaptation disabled)); lung: 67.8571% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.7736% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.5108% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.8676% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.4220% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 74.0260% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.9655% (minimum 97%, Baseline (adaptation disabled)); retina: 52.7778% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.7692% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 52.1341% (minimum 99%, Baseline (adaptation disabled)); skin: 67.3228% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.2113% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.1906% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.6225% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.0656% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.3393% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.2113% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,15.7,17.5,17.1,"parathyroid gland: 17.5 nTPM (protected, limit 2); thyroid gland: 17.1 nTPM (manageable, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 2); liver: 14.3 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 2); cerebral cortex: 13 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); colon: 12.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 2); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 2); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); salivary gland: 8.9 nTPM (protected, limit 2); skin: 8.3 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198586,TLK1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.45,-0.47578,-0.468659
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 69.7959% (minimum 95%, Missing); adrenal gland: 63.3333% (minimum 99%, Missing); amygdala: 61.7329% (minimum 99%, Missing); basal ganglia: 62.8676% (minimum 99%, Missing); bone marrow: 61.0714% (minimum 99%, Missing); cerebellum: 73.7069% (minimum 99%, Missing); cerebral cortex: 56.8106% (minimum 99%, Missing); choroid plexus: 68.4000% (minimum 99%, Missing); colon: 57.5758% (minimum 97%, Missing); duodenum: 65.0190% (minimum 99%, Missing); esophagus: 65.5172% (minimum 97%, Missing); heart muscle: 71.8487% (minimum 99%, Missing); hippocampal formation: 62.4088% (minimum 99%, Missing); hypothalamus: 64.2857% (minimum 99%, Missing); kidney: 57.7703% (minimum 99%, Missing); liver: 54.4586% (minimum 99%, Missing); lung: 67.8571% (minimum 99%, Missing); lymph node: 53.7736% (minimum 97%, Missing); midbrain: 61.5108% (minimum 99%, Missing); pancreas: 62.8676% (minimum 99%, Missing); parathyroid gland: 49.4220% (minimum 97%, Missing); pituitary gland: 74.0260% (minimum 99%, Missing); rectum: 58.9655% (minimum 97%, Missing); retina: 52.7778% (minimum 99%, Missing); salivary gland: 65.7692% (minimum 97%, Missing); skeletal muscle: 52.1341% (minimum 99%, Missing); skin: 67.3228% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 60.2113% (minimum 99%, Missing); spinal cord: 63.3333% (minimum 99%, Missing); spleen: 57.1906% (minimum 95%, Missing); stomach: 56.6225% (minimum 97%, Missing); thymus: 56.0656% (minimum 95%, Missing); thyroid gland: 50.0000% (minimum 95%, Missing); tongue: 76.3393% (minimum 97%, Missing); urinary bladder: 60.2113% (minimum 97%, Missing)",0,4,partial,15.7,17.5,17.1,"parathyroid gland: 17.5 nTPM (protected, limit 2); thyroid gland: 17.1 nTPM (manageable, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 2); liver: 14.3 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 2); cerebral cortex: 13 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); colon: 12.6 nTPM (protected, limit 2); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 2); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 2); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 2); salivary gland: 8.9 nTPM (protected, limit 2); skin: 8.3 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198586,TLK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.45,-0.47578,-0.468659
True,compatible,,True,True,False,,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000198681,MAGEA1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000198681,MAGEA1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000198681,MAGEA1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,343.6,0.2,0.4,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000198691,ABCA4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 98.0769% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 5.1829% (minimum 99%, Baseline (adaptation disabled)); duodenum: 80.9524% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.2338% (minimum 99%, Baseline (adaptation disabled)); liver: 96.2264% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0769% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.2264% (minimum 97%, Baseline (adaptation disabled)); retina: 1.4626% (minimum 99%, Baseline (adaptation disabled)); skin: 92.7273% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.4615% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,343.6,0.2,0.4,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000198691,ABCA4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0227273,-0.00773585,-0.975374
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 5.1829% (minimum 99%, Missing); duodenum: 80.9524% (minimum 95%, Enhanced); kidney: 66.2338% (minimum 99%, Missing); retina: 1.4626% (minimum 99%, Missing); small intestine: 78.4615% (minimum 95%, Enhanced)",0,3,partial,343.6,0.2,0.4,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000198691,ABCA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0122642,0.03,-0.975374
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198704,GPX6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198704,GPX6,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000198704,GPX6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,0.3,1.3,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000198723,SAXO5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.5610% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5222% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5222% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.5926% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.5222% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5222% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.0392% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.2381% (minimum 99%, Baseline (adaptation disabled)); retina: 93.8967% (minimum 99%, Baseline (adaptation disabled)); skin: 93.8967% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.6184% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.5610% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.6,0.3,1.3,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000198723,SAXO5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,-0.0110329,0.0152217,-0.0640741
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.5610% (minimum 99%, Missing); amygdala: 98.5222% (minimum 99%, Missing); basal ganglia: 98.5222% (minimum 99%, Missing); bone marrow: 92.5926% (minimum 99%, Missing); cerebral cortex: 98.5222% (minimum 99%, Missing); hippocampal formation: 98.5222% (minimum 99%, Missing); midbrain: 98.0392% (minimum 99%, Missing); pituitary gland: 95.2381% (minimum 99%, Missing); retina: 93.8967% (minimum 99%, Missing); skin: 93.8967% (minimum 95%, Missing); small intestine: 96.6184% (minimum 99%, Missing); spinal cord: 97.5610% (minimum 99%, Missing)",0,80,unavailable,1.6,0.3,1.3,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000198723,SAXO5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Loriot 2025;da Silva 2017,-0.0110329,0.0152217,-0.0640741
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,6.3,0.9,3.8,"heart muscle: 6.3 nTPM (vital, limit 6); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198754,OXCT2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.8858% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.7483% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.5275% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.9310% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 91.8499% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.4743% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.7483% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.3380% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.4743% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.6111% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.4743% (minimum 99%, Baseline (adaptation disabled)); thymus: 94.9198% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,6.3,0.9,3.8,"heart muscle: 6.3 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198754,OXCT2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.000802139,0.0174826,-0.0715006
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.7483% (minimum 99%, Missing); heart muscle: 91.8499% (minimum 95%, Enhanced); hippocampal formation: 98.4743% (minimum 99%, Missing); midbrain: 98.7483% (minimum 99%, Missing); pituitary gland: 98.4743% (minimum 99%, Missing); spinal cord: 98.4743% (minimum 99%, Missing); thymus: 94.9198% (minimum 95%, Missing)",0,4,partial,6.3,0.9,3.8,"heart muscle: 6.3 nTPM (vital, limit 6); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198754,OXCT2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.000802139,0.03,-0.0315006
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,24.8,10.3,19.5,"lung: 24.8 nTPM (vital, limit 6); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198759,EGFL6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1158/0008-5472.CAN-16-0225,Bai 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 96.1758% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,24.8,10.3,19.5,"lung: 24.8 nTPM (vital, limit 1); adipose tissue: 19.5 nTPM (manageable, limit 5); urinary bladder: 10.3 nTPM (protected, limit 2); esophagus: 4.2 nTPM (protected, limit 2); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198759,EGFL6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1158/0008-5472.CAN-16-0225,Bai 2016,0.0196828,0.0137539,-0.0282421
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,2,partial,24.8,10.3,19.5,"lung: 24.8 nTPM (vital, limit 6); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198759,EGFL6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1158/0008-5472.CAN-16-0225,Bai 2016,0.0496794,0.0274412,0.00600767
True,compatible,,True,True,False,,0,4,partial,0,0,0.1,,,52,not_established,not_triggered,,,ENSG00000198765,SYCP1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0.1,,,52,not_established,not_triggered,,,ENSG00000198765,SYCP1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0474425,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0.1,,,52,not_established,not_triggered,,,ENSG00000198765,SYCP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.4,0.4,0.7,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198785,GRIN3A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 56.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.3529% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 15.9091% (minimum 99%, Baseline (adaptation disabled)); colon: 87.5000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 42.4242% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 87.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 93.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.7778% (minimum 97%, Baseline (adaptation disabled)); midbrain: 58.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.3333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 87.5000% (minimum 97%, Baseline (adaptation disabled)); retina: 63.6364% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.5000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 82.3529% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.7778% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7.4,0.4,0.7,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198785,GRIN3A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.283333,-0.192222,-0.830909
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Missing); adrenal gland: 93.3333% (minimum 99%, Missing); amygdala: 56.0000% (minimum 99%, Missing); basal ganglia: 82.3529% (minimum 99%, Missing); bone marrow: 93.3333% (minimum 99%, Missing); cerebral cortex: 15.9091% (minimum 99%, Missing); colon: 87.5000% (minimum 97%, Missing); duodenum: 93.3333% (minimum 99%, Missing); esophagus: 93.3333% (minimum 97%, Missing); heart muscle: 70.0000% (minimum 99%, Missing); hippocampal formation: 58.3333% (minimum 99%, Missing); hypothalamus: 42.4242% (minimum 99%, Missing); kidney: 93.3333% (minimum 99%, Missing); liver: 87.5000% (minimum 99%, Missing); lung: 93.3333% (minimum 99%, Missing); lymph node: 77.7778% (minimum 97%, Missing); midbrain: 58.3333% (minimum 99%, Missing); pancreas: 93.3333% (minimum 99%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); rectum: 87.5000% (minimum 97%, Missing); retina: 63.6364% (minimum 99%, Missing); salivary gland: 87.5000% (minimum 97%, Missing); skeletal muscle: 93.3333% (minimum 99%, Missing); skin: 82.3529% (minimum 95%, Missing); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spinal cord: 77.7778% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 93.3333% (minimum 97%, Missing); thymus: 93.3333% (minimum 95%, Missing); thyroid gland: 93.3333% (minimum 95%, Missing); tongue: 93.3333% (minimum 97%, Missing)",0,80,unavailable,7.4,0.4,0.7,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198785,GRIN3A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.283333,-0.192222,-0.830909
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000198798,MAGEB3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000198798,MAGEB3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000198798,MAGEB3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,40.6,28,22.4,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 2); adipose tissue: 22.4 nTPM (manageable, limit 5); skin: 22.2 nTPM (manageable, limit 5); thymus: 21.6 nTPM (manageable, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (manageable, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 2); rectum: 17.6 nTPM (protected, limit 2); lymph node: 17.4 nTPM (protected, limit 2); colon: 17.2 nTPM (protected, limit 2); smooth muscle: 17.1 nTPM (vital, limit 1); small intestine: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 2); hippocampal formation: 16.9 nTPM (vital, limit 1); spleen: 16.7 nTPM (manageable, limit 5); pituitary gland: 16.6 nTPM (vital, limit 1); salivary gland: 16.4 nTPM (protected, limit 2); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 2); amygdala: 14.7 nTPM (vital, limit 1); kidney: 13 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198815,FOXJ3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 49.3213% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.5569% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.7260% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.7739% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 42.2481% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.0830% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 54.0943% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.3068% (minimum 99%, Baseline (adaptation disabled)); colon: 55.8974% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.7601% (minimum 99%, Baseline (adaptation disabled)); esophagus: 59.2391% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.9126% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 56.3307% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.1333% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.6437% (minimum 99%, Baseline (adaptation disabled)); liver: 57.9787% (minimum 99%, Baseline (adaptation disabled)); lung: 54.7739% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.6122% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.6884% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.2289% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.2941% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.7708% (minimum 99%, Baseline (adaptation disabled)); rectum: 55.3299% (minimum 97%, Baseline (adaptation disabled)); retina: 53.6946% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.0681% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 34.9359% (minimum 99%, Baseline (adaptation disabled)); skin: 49.5455% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.0411% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.0411% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.7427% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.6234% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.1856% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.2304% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.9604% (minimum 95%, Baseline (adaptation disabled)); tongue: 43.7751% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.1899% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,40.6,28,22.4,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 2); adipose tissue: 22.4 nTPM (manageable, limit 5); skin: 22.2 nTPM (manageable, limit 5); thymus: 21.6 nTPM (manageable, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (manageable, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 2); rectum: 17.6 nTPM (protected, limit 2); lymph node: 17.4 nTPM (protected, limit 2); colon: 17.2 nTPM (protected, limit 2); smooth muscle: 17.1 nTPM (vital, limit 1); small intestine: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 2); hippocampal formation: 16.9 nTPM (vital, limit 1); spleen: 16.7 nTPM (manageable, limit 5); pituitary gland: 16.6 nTPM (vital, limit 1); salivary gland: 16.4 nTPM (protected, limit 2); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 2); amygdala: 14.7 nTPM (vital, limit 1); kidney: 13 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198815,FOXJ3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.456787,-0.532249,-0.640641
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 49.3213% (minimum 95%, Missing); adrenal gland: 63.5569% (minimum 99%, Missing); amygdala: 59.7260% (minimum 99%, Missing); basal ganglia: 54.7739% (minimum 99%, Missing); bone marrow: 42.2481% (minimum 99%, Missing); cerebellum: 43.0830% (minimum 99%, Missing); cerebral cortex: 54.0943% (minimum 99%, Missing); choroid plexus: 64.3068% (minimum 99%, Missing); colon: 55.8974% (minimum 97%, Missing); duodenum: 58.7601% (minimum 99%, Missing); esophagus: 59.2391% (minimum 97%, Missing); heart muscle: 52.9126% (minimum 99%, Missing); hippocampal formation: 56.3307% (minimum 99%, Missing); hypothalamus: 58.1333% (minimum 99%, Missing); kidney: 62.6437% (minimum 99%, Missing); liver: 57.9787% (minimum 99%, Missing); lung: 54.7739% (minimum 99%, Missing); lymph node: 55.6122% (minimum 97%, Missing); midbrain: 64.6884% (minimum 99%, Missing); pancreas: 54.2289% (minimum 99%, Missing); parathyroid gland: 51.2941% (minimum 97%, Missing); pituitary gland: 56.7708% (minimum 99%, Missing); rectum: 55.3299% (minimum 97%, Missing); retina: 53.6946% (minimum 99%, Missing); salivary gland: 57.0681% (minimum 97%, Missing); skeletal muscle: 34.9359% (minimum 99%, Missing); skin: 49.5455% (minimum 95%, Missing); small intestine: 56.0411% (minimum 99%, Missing); smooth muscle: 56.0411% (minimum 99%, Missing); spinal cord: 63.7427% (minimum 99%, Missing); spleen: 56.6234% (minimum 95%, Missing); stomach: 56.1856% (minimum 97%, Missing); thymus: 50.2304% (minimum 95%, Missing); thyroid gland: 53.9604% (minimum 95%, Missing); tongue: 43.7751% (minimum 97%, Missing); urinary bladder: 55.1899% (minimum 97%, Missing)",0,80,unavailable,40.6,28,22.4,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 2); adipose tissue: 22.4 nTPM (manageable, limit 5); skin: 22.2 nTPM (manageable, limit 5); thymus: 21.6 nTPM (manageable, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (manageable, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 2); rectum: 17.6 nTPM (protected, limit 2); lymph node: 17.4 nTPM (protected, limit 2); colon: 17.2 nTPM (protected, limit 2); smooth muscle: 17.1 nTPM (vital, limit 1); small intestine: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 2); hippocampal formation: 16.9 nTPM (vital, limit 1); spleen: 16.7 nTPM (manageable, limit 5); pituitary gland: 16.6 nTPM (vital, limit 1); salivary gland: 16.4 nTPM (protected, limit 2); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 2); amygdala: 14.7 nTPM (vital, limit 1); kidney: 13 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198815,FOXJ3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.456787,-0.532249,-0.640641
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,169.4,141.1,68.4,"skeletal muscle: 169.4 nTPM (vital, limit 2); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 2); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 2); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 2); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (manageable, limit 10); stomach: 65.9 nTPM (protected, limit 2); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (manageable, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); salivary gland: 49.7 nTPM (protected, limit 4); lung: 49.1 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 4); small intestine: 46.5 nTPM (vital, limit 1); spleen: 38.6 nTPM (manageable, limit 5); skin: 37.5 nTPM (manageable, limit 5); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 2); esophagus: 31 nTPM (protected, limit 2); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 2); thymus: 13.7 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198816,ZNF358,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6420% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.6789% (minimum 99%, Baseline (adaptation disabled)); amygdala: 42.6653% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 50.4113% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 52.4450% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 37.0787% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 69.6429% (minimum 99%, Baseline (adaptation disabled)); colon: 45.1341% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.4589% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 44.7574% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 43.8650% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 51.5315% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.5364% (minimum 99%, Baseline (adaptation disabled)); liver: 56.7460% (minimum 99%, Baseline (adaptation disabled)); lung: 63.6027% (minimum 99%, Baseline (adaptation disabled)); lymph node: 89.2820% (minimum 97%, Baseline (adaptation disabled)); midbrain: 49.7680% (minimum 99%, Baseline (adaptation disabled)); pancreas: 63.6027% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.1735% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.1316% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.8986% (minimum 97%, Baseline (adaptation disabled)); retina: 88.2716% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.3210% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 33.6207% (minimum 99%, Baseline (adaptation disabled)); skin: 69.5864% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.8526% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.4433% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.9343% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.9711% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.5590% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.2312% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.6247% (minimum 95%, Baseline (adaptation disabled)); tongue: 37.8140% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 50.0876% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,169.4,141.1,68.4,"skeletal muscle: 169.4 nTPM (vital, limit 1); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 2); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 2); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 2); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (manageable, limit 5); stomach: 65.9 nTPM (protected, limit 2); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (manageable, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); salivary gland: 49.7 nTPM (protected, limit 2); lung: 49.1 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 2); small intestine: 46.5 nTPM (vital, limit 1); spleen: 38.6 nTPM (manageable, limit 5); skin: 37.5 nTPM (manageable, limit 5); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 1); esophagus: 31 nTPM (protected, limit 2); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 2); thymus: 13.7 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198816,ZNF358,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.39358,-0.59186,-0.653793
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6420% (minimum 90%, Approved); adrenal gland: 60.6789% (minimum 99%, Missing); amygdala: 42.6653% (minimum 99%, Missing); basal ganglia: 50.4113% (minimum 99%, Missing); bone marrow: 97.5000% (minimum 99%, Missing); cerebellum: 52.4450% (minimum 99%, Missing); cerebral cortex: 37.0787% (minimum 99%, Missing); choroid plexus: 69.6429% (minimum 99%, Missing); colon: 45.1341% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 73.4589% (minimum 97%, Missing); heart muscle: 44.7574% (minimum 99%, Missing); hippocampal formation: 43.8650% (minimum 99%, Missing); hypothalamus: 51.5315% (minimum 99%, Missing); kidney: 62.5364% (minimum 99%, Missing); liver: 56.7460% (minimum 99%, Missing); lung: 63.6027% (minimum 99%, Missing); lymph node: 89.2820% (minimum 97%, Missing); midbrain: 49.7680% (minimum 99%, Missing); pancreas: 63.6027% (minimum 99%, Missing); parathyroid gland: 64.1735% (minimum 95%, Approved); pituitary gland: 59.1316% (minimum 99%, Missing); rectum: 82.8986% (minimum 97%, Missing); retina: 88.2716% (minimum 99%, Missing); salivary gland: 63.3210% (minimum 95%, Approved); skeletal muscle: 33.6207% (minimum 98%, Approved); skin: 69.5864% (minimum 95%, Missing); small intestine: 64.8526% (minimum 99%, Missing); smooth muscle: 70.4433% (minimum 98%, Approved); spinal cord: 56.9343% (minimum 99%, Missing); spleen: 68.9711% (minimum 95%, Missing); stomach: 56.5590% (minimum 97%, Missing); thymus: 86.2312% (minimum 95%, Missing); thyroid gland: 59.6247% (minimum 95%, Missing); tongue: 37.8140% (minimum 97%, Missing); urinary bladder: 50.0876% (minimum 97%, Missing)",0,3,partial,169.4,141.1,68.4,"skeletal muscle: 169.4 nTPM (vital, limit 2); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 2); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 2); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 2); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (manageable, limit 10); stomach: 65.9 nTPM (protected, limit 2); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (manageable, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); salivary gland: 49.7 nTPM (protected, limit 4); lung: 49.1 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 4); small intestine: 46.5 nTPM (vital, limit 1); spleen: 38.6 nTPM (manageable, limit 5); skin: 37.5 nTPM (manageable, limit 5); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 2); esophagus: 31 nTPM (protected, limit 2); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 2); thymus: 13.7 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198816,ZNF358,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.353753,-0.59186,-0.643793
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,8,partial,23.5,12.9,25.3,"thymus: 25.3 nTPM (manageable, limit 5); bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 2); rectum: 8.4 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); smooth muscle: 4.6 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); midbrain: 2.9 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198826,ARHGAP11A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 84.0426% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 89.7727% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.8696% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.7640% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 25.1592% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.3415% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.8046% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.3415% (minimum 99%, Baseline (adaptation disabled)); colon: 52.3179% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.0882% (minimum 99%, Baseline (adaptation disabled)); esophagus: 61.2403% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.8605% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.9462% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.8696% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.9412% (minimum 99%, Baseline (adaptation disabled)); liver: 86.8132% (minimum 99%, Baseline (adaptation disabled)); lung: 83.1579% (minimum 99%, Baseline (adaptation disabled)); lymph node: 37.9808% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.1481% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.4510% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.7778% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.9412% (minimum 99%, Baseline (adaptation disabled)); rectum: 48.4663% (minimum 97%, Baseline (adaptation disabled)); retina: 95.1807% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 86.8132% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.8046% (minimum 99%, Baseline (adaptation disabled)); skin: 65.8333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 52.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.2000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 55.2448% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.2381% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.9115% (minimum 97%, Baseline (adaptation disabled)); thymus: 23.7952% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.7778% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.1807% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.9615% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,23.5,12.9,25.3,"thymus: 25.3 nTPM (manageable, limit 5); bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 2); rectum: 8.4 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); smooth muscle: 4.6 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); midbrain: 2.9 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198826,ARHGAP11A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.712048,-0.590192,-0.738408
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 84.0426% (minimum 95%, Missing); adrenal gland: 89.7727% (minimum 99%, Missing); amygdala: 85.8696% (minimum 99%, Missing); basal ganglia: 88.7640% (minimum 99%, Missing); bone marrow: 25.1592% (minimum 99%, Missing); cerebellum: 96.3415% (minimum 99%, Missing); cerebral cortex: 90.8046% (minimum 99%, Missing); choroid plexus: 96.3415% (minimum 99%, Missing); colon: 52.3179% (minimum 97%, Missing); duodenum: 58.0882% (minimum 99%, Missing); esophagus: 61.2403% (minimum 97%, Missing); heart muscle: 91.8605% (minimum 99%, Missing); hippocampal formation: 84.9462% (minimum 99%, Missing); hypothalamus: 85.8696% (minimum 99%, Missing); kidney: 92.9412% (minimum 95%, Enhanced); liver: 86.8132% (minimum 95%, Enhanced); lung: 83.1579% (minimum 99%, Missing); lymph node: 37.9808% (minimum 97%, Missing); midbrain: 73.1481% (minimum 99%, Missing); pancreas: 77.4510% (minimum 99%, Missing); pituitary gland: 92.9412% (minimum 99%, Missing); rectum: 48.4663% (minimum 97%, Missing); retina: 95.1807% (minimum 99%, Missing); salivary gland: 86.8132% (minimum 97%, Missing); skeletal muscle: 90.8046% (minimum 99%, Missing); skin: 65.8333% (minimum 95%, Missing); small intestine: 52.6667% (minimum 99%, Missing); smooth muscle: 63.2000% (minimum 99%, Missing); spinal cord: 55.2448% (minimum 99%, Missing); stomach: 69.9115% (minimum 97%, Missing); thymus: 23.7952% (minimum 95%, Missing); thyroid gland: 87.7778% (minimum 95%, Missing); tongue: 95.1807% (minimum 97%, Missing); urinary bladder: 75.9615% (minimum 97%, Missing)",0,8,partial,23.5,12.9,25.3,"thymus: 25.3 nTPM (manageable, limit 5); bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 2); rectum: 8.4 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 2); smooth muscle: 4.6 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 2); midbrain: 2.9 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198826,ARHGAP11A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.712048,-0.590192,-0.738408
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,173.9,7.2,14.6,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); spleen: 14.6 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 2); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); stomach: 4.3 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198865,CCDC152,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.2876% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 59.2593% (minimum 99%, Baseline (adaptation disabled)); amygdala: 60.6061% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.3942% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.2105% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 86.9565% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.7273% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.7664% (minimum 99%, Baseline (adaptation disabled)); colon: 61.0687% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.7966% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.4314% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.6129% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.1429% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 48.7805% (minimum 99%, Baseline (adaptation disabled)); liver: 4.3980% (minimum 99%, Baseline (adaptation disabled)); lung: 57.5540% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.6316% (minimum 97%, Baseline (adaptation disabled)); midbrain: 41.2371% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.2269% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 51.6129% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.3855% (minimum 97%, Baseline (adaptation disabled)); retina: 78.4314% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.4717% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.4742% (minimum 99%, Baseline (adaptation disabled)); skin: 71.4286% (minimum 95%, Baseline (adaptation disabled)); small intestine: 38.0952% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 29.9625% (minimum 99%, Baseline (adaptation disabled)); spleen: 35.3982% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.0407% (minimum 97%, Baseline (adaptation disabled)); thymus: 67.2269% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.4286% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.0233% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.4717% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,173.9,7.2,14.6,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); spleen: 14.6 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 2); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); stomach: 4.3 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198865,CCDC152,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.596018,-0.443684,-0.94602
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.2876% (minimum 95%, Missing); adrenal gland: 59.2593% (minimum 99%, Missing); amygdala: 60.6061% (minimum 99%, Missing); basal ganglia: 58.3942% (minimum 99%, Missing); bone marrow: 84.2105% (minimum 99%, Missing); cerebellum: 86.9565% (minimum 99%, Missing); cerebral cortex: 72.7273% (minimum 99%, Missing); choroid plexus: 74.7664% (minimum 99%, Missing); colon: 61.0687% (minimum 97%, Missing); duodenum: 67.7966% (minimum 99%, Missing); esophagus: 78.4314% (minimum 97%, Missing); heart muscle: 51.6129% (minimum 99%, Missing); hippocampal formation: 57.1429% (minimum 99%, Missing); hypothalamus: 53.3333% (minimum 99%, Missing); kidney: 48.7805% (minimum 99%, Missing); liver: 4.3980% (minimum 99%, Missing); lung: 57.5540% (minimum 99%, Missing); lymph node: 52.6316% (minimum 97%, Missing); midbrain: 41.2371% (minimum 99%, Missing); pancreas: 67.2269% (minimum 99%, Missing); pituitary gland: 51.6129% (minimum 99%, Missing); rectum: 96.3855% (minimum 97%, Missing); retina: 78.4314% (minimum 99%, Missing); salivary gland: 75.4717% (minimum 97%, Missing); skeletal muscle: 82.4742% (minimum 99%, Missing); skin: 71.4286% (minimum 95%, Missing); small intestine: 38.0952% (minimum 99%, Missing); smooth muscle: 95.2381% (minimum 99%, Missing); spinal cord: 29.9625% (minimum 99%, Missing); spleen: 35.3982% (minimum 95%, Missing); stomach: 65.0407% (minimum 97%, Missing); thymus: 67.2269% (minimum 95%, Missing); thyroid gland: 71.4286% (minimum 95%, Missing); tongue: 93.0233% (minimum 97%, Missing); urinary bladder: 75.4717% (minimum 97%, Missing)",0,4,partial,173.9,7.2,14.6,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); spleen: 14.6 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 2); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 2); stomach: 4.3 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); retina: 2.2 nTPM (vital, limit 1); esophagus: 2.2 nTPM (protected, limit 2); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000198865,CCDC152,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.596018,-0.443684,-0.94602
True,compatible,,True,True,False,,0,80,unavailable,0.6,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000198870,STKLD1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.9798% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.0396% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.9796% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.1748% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.1748% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9796% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.9796% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.0396% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.9798% (minimum 99%, Baseline (adaptation disabled)); liver: 97.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 98.9796% (minimum 99%, Baseline (adaptation disabled)); midbrain: 96.0396% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.9796% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.9798% (minimum 99%, Baseline (adaptation disabled)); retina: 98.9796% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.9798% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9796% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.0980% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000198870,STKLD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.029798,0.00979798,-0.0482524
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 97.9798% (minimum 99%, Missing); amygdala: 97.0000% (minimum 99%, Missing); basal ganglia: 96.0396% (minimum 99%, Missing); bone marrow: 98.9796% (minimum 99%, Missing); cerebellum: 94.1748% (minimum 99%, Missing); cerebral cortex: 94.1748% (minimum 99%, Missing); duodenum: 98.9796% (minimum 99%, Missing); heart muscle: 98.9796% (minimum 99%, Missing); hippocampal formation: 96.0396% (minimum 99%, Missing); hypothalamus: 97.0000% (minimum 99%, Missing); kidney: 97.9798% (minimum 99%, Missing); liver: 97.0000% (minimum 99%, Missing); lung: 98.9796% (minimum 99%, Missing); midbrain: 96.0396% (minimum 99%, Missing); pancreas: 98.9796% (minimum 99%, Missing); pituitary gland: 97.9798% (minimum 99%, Missing); retina: 98.9796% (minimum 99%, Missing); skeletal muscle: 97.9798% (minimum 99%, Missing); small intestine: 98.9796% (minimum 99%, Missing); spinal cord: 95.0980% (minimum 99%, Missing)",0,80,unavailable,0.6,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000198870,STKLD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.029798,0.00979798,-0.0482524
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,21.7,0.1,0.5,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000198883,PNMA5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 54.1401% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 33.7302% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.2955% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7011% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.3846% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 28.1457% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.3978% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.4255% (minimum 99%, Baseline (adaptation disabled)); retina: 98.8372% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.7011% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.4066% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.4444% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,21.7,0.1,0.5,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000198883,PNMA5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00555556,0.0183721,-0.708543
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 54.1401% (minimum 99%, Missing); basal ganglia: 33.7302% (minimum 99%, Missing); cerebral cortex: 48.2955% (minimum 99%, Missing); choroid plexus: 97.7011% (minimum 99%, Missing); hippocampal formation: 65.3846% (minimum 99%, Missing); hypothalamus: 28.1457% (minimum 99%, Missing); midbrain: 91.3978% (minimum 99%, Missing); pituitary gland: 90.4255% (minimum 99%, Missing); retina: 98.8372% (minimum 99%, Missing); spinal cord: 93.4066% (minimum 99%, Missing)",0,1,partial,21.7,0.1,0.5,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000198883,PNMA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0183721,-0.708543
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.2,7.3,5,"salivary gland: 7.3 nTPM (protected, limit 2); lymph node: 3.8 nTPM (protected, limit 2); cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198885,ITPRIPL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.1089% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.5401% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.1818% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.0854% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 89.4040% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.1818% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9011% (minimum 99%, Baseline (adaptation disabled)); colon: 96.7742% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.7447% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.7368% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.7447% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5401% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.1818% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.1818% (minimum 99%, Baseline (adaptation disabled)); liver: 98.1818% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0704% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.6623% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.5401% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.4064% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.5401% (minimum 99%, Baseline (adaptation disabled)); retina: 96.7742% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.7172% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.7368% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.4056% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.7742% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1223% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.5254% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.0854% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.3750% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.4256% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.0704% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.2,7.3,5,"salivary gland: 7.3 nTPM (protected, limit 2); lymph node: 3.8 nTPM (protected, limit 2); cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198885,ITPRIPL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.10625,-0.182828,-0.0959603
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.1089% (minimum 95%, Missing); adrenal gland: 98.5401% (minimum 99%, Missing); amygdala: 98.1818% (minimum 99%, Missing); bone marrow: 96.0854% (minimum 99%, Missing); cerebellum: 89.4040% (minimum 99%, Missing); cerebral cortex: 98.1818% (minimum 99%, Missing); choroid plexus: 98.9011% (minimum 99%, Missing); colon: 96.7742% (minimum 97%, Missing); duodenum: 95.7447% (minimum 99%, Missing); esophagus: 94.7368% (minimum 97%, Missing); heart muscle: 95.7447% (minimum 99%, Missing); hippocampal formation: 98.5401% (minimum 99%, Missing); hypothalamus: 98.1818% (minimum 99%, Missing); kidney: 98.1818% (minimum 99%, Missing); liver: 98.1818% (minimum 99%, Missing); lung: 95.0704% (minimum 99%, Missing); lymph node: 87.6623% (minimum 97%, Missing); midbrain: 98.5401% (minimum 99%, Missing); pancreas: 95.4064% (minimum 99%, Missing); pituitary gland: 98.5401% (minimum 99%, Missing); retina: 96.7742% (minimum 99%, Missing); salivary gland: 78.7172% (minimum 97%, Missing); skeletal muscle: 94.7368% (minimum 99%, Missing); small intestine: 94.4056% (minimum 99%, Missing); smooth muscle: 96.7742% (minimum 99%, Missing); spinal cord: 97.1223% (minimum 99%, Missing); spleen: 91.5254% (minimum 95%, Missing); stomach: 96.0854% (minimum 97%, Missing); thymus: 84.3750% (minimum 95%, Missing); tongue: 93.4256% (minimum 97%, Missing); urinary bladder: 95.0704% (minimum 97%, Missing)",0,80,unavailable,3.2,7.3,5,"salivary gland: 7.3 nTPM (protected, limit 2); lymph node: 3.8 nTPM (protected, limit 2); cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198885,ITPRIPL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.10625,-0.182828,-0.0959603
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,1.5,0.8,1,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / germinal center cells,ENSG00000198889,DCAF12L1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 98.3607% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.3607% (minimum 99%, Baseline (adaptation disabled)); kidney: 80.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.7742% (minimum 99%, Baseline (adaptation disabled)); spleen: 85.7143% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.2353% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.7742% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,1.5,0.8,1,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / germinal center cells,ENSG00000198889,DCAF12L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0928571,-0.0876471,-0.19
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 98.3607% (minimum 99%, Missing); hypothalamus: 98.3607% (minimum 99%, Missing); kidney: 80.0000% (minimum 99%, Missing); pituitary gland: 96.7742% (minimum 99%, Missing); spleen: 85.7143% (minimum 90%, Approved); stomach: 88.2353% (minimum 97%, Missing); urinary bladder: 96.7742% (minimum 97%, Missing)",0,5,partial,1.5,0.8,1,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / germinal center cells,ENSG00000198889,DCAF12L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.0428571,-0.0876471,-0.19
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,28.9,15.6,12.4,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 2); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (manageable, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 2); adrenal gland: 9.4 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 4); stomach: 6.4 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 4); rectum: 4.5 nTPM (protected, limit 2); liver: 4.1 nTPM (vital, limit 2); small intestine: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000198919,DZIP3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.0466% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 78.1395% (minimum 99%, Baseline (adaptation disabled)); amygdala: 74.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 67.8788% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.8396% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.2929% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 59.7865% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.7595% (minimum 99%, Baseline (adaptation disabled)); colon: 87.0466% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.8033% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.0804% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 72.4138% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.3696% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.1905% (minimum 99%, Baseline (adaptation disabled)); liver: 89.1247% (minimum 99%, Baseline (adaptation disabled)); lung: 84.2105% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.2414% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.8879% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.5979% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 81.7518% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.4348% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.1890% (minimum 97%, Baseline (adaptation disabled)); retina: 53.7600% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.8108% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 73.8462% (minimum 99%, Baseline (adaptation disabled)); skin: 90.5660% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.8396% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.0466% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.3828% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.5755% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.1909% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 73.0435% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.2927% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 87.0466% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,28.9,15.6,12.4,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 2); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (manageable, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 2); adrenal gland: 9.4 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); spleen: 8.1 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 2); stomach: 6.4 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 2); rectum: 4.5 nTPM (protected, limit 2); liver: 4.1 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000198919,DZIP3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.219565,-0.287073,-0.4524
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 87.0466% (minimum 90%, Approved); adrenal gland: 78.1395% (minimum 99%, Missing); amygdala: 74.6667% (minimum 99%, Missing); basal ganglia: 67.8788% (minimum 99%, Missing); bone marrow: 89.8396% (minimum 99%, Missing); cerebellum: 70.2929% (minimum 99%, Missing); cerebral cortex: 59.7865% (minimum 99%, Missing); choroid plexus: 60.7595% (minimum 99%, Missing); colon: 87.0466% (minimum 97%, Missing); duodenum: 91.8033% (minimum 99%, Missing); esophagus: 90.0804% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); hippocampal formation: 72.4138% (minimum 99%, Missing); hypothalamus: 65.3696% (minimum 99%, Missing); kidney: 76.1905% (minimum 99%, Missing); liver: 89.1247% (minimum 98%, Approved); lung: 84.2105% (minimum 99%, Missing); lymph node: 77.2414% (minimum 97%, Missing); midbrain: 76.8879% (minimum 99%, Missing); pancreas: 86.5979% (minimum 99%, Missing); parathyroid gland: 81.7518% (minimum 95%, Approved); pituitary gland: 58.4348% (minimum 99%, Missing); rectum: 88.1890% (minimum 97%, Missing); retina: 53.7600% (minimum 99%, Missing); salivary gland: 90.8108% (minimum 97%, Missing); skeletal muscle: 73.8462% (minimum 99%, Missing); skin: 90.5660% (minimum 95%, Missing); small intestine: 89.8396% (minimum 99%, Missing); smooth muscle: 87.0466% (minimum 99%, Missing); spinal cord: 80.3828% (minimum 99%, Missing); spleen: 80.5755% (minimum 90%, Approved); stomach: 84.0000% (minimum 97%, Missing); thymus: 80.1909% (minimum 95%, Missing); thyroid gland: 73.0435% (minimum 95%, Missing); tongue: 68.2927% (minimum 97%, Missing); urinary bladder: 87.0466% (minimum 95%, Approved)",0,4,partial,28.9,15.6,12.4,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 2); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (manageable, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 2); adrenal gland: 9.4 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 4); stomach: 6.4 nTPM (protected, limit 2); lung: 6.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); urinary bladder: 5 nTPM (protected, limit 4); rectum: 4.5 nTPM (protected, limit 2); liver: 4.1 nTPM (vital, limit 2); small intestine: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000198919,DZIP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.219565,-0.287073,-0.4524
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1.9,0.3,0.1,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,ENSG00000198930,CSAG1,reproductive_required,False,True,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 43.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 40.6250% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.4706% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 44.8276% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 44.8276% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 56.5217% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.2500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 44.8276% (minimum 99%, Baseline (adaptation disabled)); small intestine: 92.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 68.4211% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 92.8571% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.9,0.3,0.1,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,ENSG00000198930,CSAG1,current_fixed,False,True,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,10.1038/ncomms10499,Wang 2016,-0.0214286,-0.1575,-0.58375
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 43.3333% (minimum 99%, Missing); basal ganglia: 40.6250% (minimum 99%, Missing); cerebellum: 76.4706% (minimum 99%, Missing); cerebral cortex: 44.8276% (minimum 99%, Missing); hippocampal formation: 44.8276% (minimum 99%, Missing); hypothalamus: 56.5217% (minimum 99%, Missing); lymph node: 81.2500% (minimum 97%, Missing); midbrain: 44.8276% (minimum 99%, Missing); small intestine: 92.8571% (minimum 99%, Missing); spinal cord: 68.4211% (minimum 99%, Missing); thyroid gland: 92.8571% (minimum 95%, Missing)",0,80,unavailable,1.9,0.3,0.1,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,ENSG00000198930,CSAG1,current_adaptive,False,True,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,10.1038/ncomms10499,Wang 2016,-0.0214286,-0.1575,-0.58375
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,41.1,9.8,23.8,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198948,MFAP3L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.1677% (minimum 99%, Baseline (adaptation disabled)); amygdala: 69.6594% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 63.0252% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.5551% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.5827% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.7711% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 52.2648% (minimum 99%, Baseline (adaptation disabled)); colon: 94.5378% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.9011% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.3597% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.7023% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.8752% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.8108% (minimum 99%, Baseline (adaptation disabled)); liver: 55.3506% (minimum 99%, Baseline (adaptation disabled)); lung: 94.5378% (minimum 99%, Baseline (adaptation disabled)); midbrain: 65.5977% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7742% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.7193% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.8367% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.9488% (minimum 97%, Baseline (adaptation disabled)); retina: 65.0289% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.7447% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.1804% (minimum 99%, Baseline (adaptation disabled)); skin: 65.4070% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.0392% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.8367% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.7656% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 94.3396% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.3390% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 82.1168% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,41.1,9.8,23.8,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); skin: 23.8 nTPM (manageable, limit 5); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 2); parathyroid gland: 6.3 nTPM (protected, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); tongue: 2.2 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198948,MFAP3L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.29593,-0.148832,-0.467352
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.1677% (minimum 99%, Missing); amygdala: 69.6594% (minimum 99%, Missing); basal ganglia: 63.0252% (minimum 99%, Missing); bone marrow: 93.5551% (minimum 95%, Enhanced); cerebellum: 88.5827% (minimum 95%, Enhanced); cerebral cortex: 67.7711% (minimum 99%, Missing); choroid plexus: 52.2648% (minimum 99%, Missing); heart muscle: 96.3597% (minimum 99%, Missing); hippocampal formation: 68.7023% (minimum 99%, Missing); hypothalamus: 74.8752% (minimum 99%, Missing); kidney: 60.8108% (minimum 99%, Missing); liver: 55.3506% (minimum 99%, Missing); lung: 94.5378% (minimum 95%, Enhanced); midbrain: 65.5977% (minimum 99%, Missing); pituitary gland: 91.8367% (minimum 99%, Missing); retina: 65.0289% (minimum 99%, Missing); skeletal muscle: 90.1804% (minimum 99%, Missing); small intestine: 98.0392% (minimum 99%, Missing); smooth muscle: 91.8367% (minimum 95%, Enhanced); spinal cord: 66.7656% (minimum 99%, Missing); tongue: 95.3390% (minimum 97%, Missing)",0,2,partial,41.1,9.8,23.8,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); tongue: 2.2 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000198948,MFAP3L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0368421,-0.0166102,-0.467352
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6,13.6,8.2,"parathyroid gland: 13.6 nTPM (protected, limit 2); skin: 8.2 nTPM (manageable, limit 5); lymph node: 7.7 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); spleen: 6.2 nTPM (manageable, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203326,ZNF525,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.3953% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 68.6275% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.8148% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.6774% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.9474% (minimum 99%, Baseline (adaptation disabled)); colon: 73.4266% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.4266% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.9178% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.0312% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.0312% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 82.6772% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.6364% (minimum 99%, Baseline (adaptation disabled)); liver: 82.0312% (minimum 99%, Baseline (adaptation disabled)); lung: 76.0870% (minimum 99%, Baseline (adaptation disabled)); lymph node: 57.6923% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.6774% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.0244% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 43.5685% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.0377% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.7419% (minimum 97%, Baseline (adaptation disabled)); retina: 68.6275% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.4698% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.3043% (minimum 99%, Baseline (adaptation disabled)); skin: 56.1497% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.8790% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.7692% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.6772% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.8743% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.0377% (minimum 97%, Baseline (adaptation disabled)); thymus: 62.5000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 67.3077% (minimum 95%, Baseline (adaptation disabled)); tongue: 86.0656% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.0789% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6,13.6,8.2,"parathyroid gland: 13.6 nTPM (protected, limit 2); skin: 8.2 nTPM (manageable, limit 5); lymph node: 7.7 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); spleen: 6.2 nTPM (manageable, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203326,ZNF525,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.388503,-0.534315,-0.353636
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.7778% (minimum 95%, Missing); adrenal gland: 70.0000% (minimum 99%, Missing); amygdala: 83.3333% (minimum 99%, Missing); basal ganglia: 81.3953% (minimum 99%, Missing); bone marrow: 68.6275% (minimum 99%, Missing); cerebellum: 64.8148% (minimum 99%, Missing); cerebral cortex: 84.6774% (minimum 99%, Missing); choroid plexus: 78.9474% (minimum 99%, Missing); colon: 73.4266% (minimum 97%, Missing); duodenum: 73.4266% (minimum 99%, Missing); esophagus: 71.9178% (minimum 97%, Missing); heart muscle: 82.0312% (minimum 99%, Missing); hippocampal formation: 82.0312% (minimum 99%, Missing); hypothalamus: 82.6772% (minimum 99%, Missing); kidney: 63.6364% (minimum 99%, Missing); liver: 82.0312% (minimum 99%, Missing); lung: 76.0870% (minimum 99%, Missing); lymph node: 57.6923% (minimum 97%, Missing); midbrain: 84.6774% (minimum 99%, Missing); pancreas: 64.0244% (minimum 99%, Missing); parathyroid gland: 43.5685% (minimum 97%, Missing); pituitary gland: 66.0377% (minimum 99%, Missing); rectum: 67.7419% (minimum 97%, Missing); retina: 68.6275% (minimum 99%, Missing); salivary gland: 70.4698% (minimum 97%, Missing); skeletal muscle: 91.3043% (minimum 99%, Missing); skin: 56.1497% (minimum 95%, Missing); small intestine: 66.8790% (minimum 99%, Missing); smooth muscle: 80.7692% (minimum 99%, Missing); spinal cord: 82.6772% (minimum 99%, Missing); spleen: 62.8743% (minimum 95%, Missing); stomach: 66.0377% (minimum 97%, Missing); thymus: 62.5000% (minimum 95%, Missing); thyroid gland: 67.3077% (minimum 95%, Missing); tongue: 86.0656% (minimum 97%, Missing); urinary bladder: 69.0789% (minimum 97%, Missing)",0,80,unavailable,6,13.6,8.2,"parathyroid gland: 13.6 nTPM (protected, limit 2); skin: 8.2 nTPM (manageable, limit 5); lymph node: 7.7 nTPM (protected, limit 2); thymus: 6.3 nTPM (manageable, limit 5); spleen: 6.2 nTPM (manageable, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 2); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 2); esophagus: 4.1 nTPM (protected, limit 2); duodenum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203326,ZNF525,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.388503,-0.534315,-0.353636
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,20.3,10.8,21.4,"thyroid gland: 21.4 nTPM (manageable, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 2); rectum: 10.8 nTPM (protected, limit 2); spinal cord: 10.1 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 2); lung: 10 nTPM (vital, limit 1); adipose tissue: 9.5 nTPM (manageable, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 2); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); salivary gland: 7.2 nTPM (protected, limit 2); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.1 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000203666,EFCAB2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3125% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 73.7705% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.2508% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.7918% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 62.6741% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.9328% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 74.5033% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 52.5701% (minimum 99%, Baseline (adaptation disabled)); colon: 81.2274% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.5486% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.4286% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.2308% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.2899% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.7918% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.5033% (minimum 99%, Baseline (adaptation disabled)); liver: 85.5513% (minimum 99%, Baseline (adaptation disabled)); lung: 69.2308% (minimum 99%, Baseline (adaptation disabled)); lymph node: 72.8155% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.5329% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.7576% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.2308% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 79.2254% (minimum 99%, Baseline (adaptation disabled)); rectum: 67.5676% (minimum 97%, Baseline (adaptation disabled)); retina: 59.2105% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.7576% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.4187% (minimum 99%, Baseline (adaptation disabled)); skin: 78.9474% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.2254% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.6561% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.0184% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.5862% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.9779% (minimum 97%, Baseline (adaptation disabled)); thymus: 80.3571% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 51.2528% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.6452% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.6713% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,20.3,10.8,21.4,"thyroid gland: 21.4 nTPM (manageable, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 2); spinal cord: 10.1 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 2); lung: 10 nTPM (vital, limit 1); adipose tissue: 9.5 nTPM (manageable, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 2); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); salivary gland: 7.2 nTPM (protected, limit 2); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.1 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000203666,EFCAB2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.437472,-0.294324,-0.464299
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 70.3125% (minimum 95%, Missing); adrenal gland: 73.7705% (minimum 99%, Missing); amygdala: 75.2508% (minimum 99%, Missing); basal ganglia: 76.7918% (minimum 99%, Missing); bone marrow: 62.6741% (minimum 98%, Approved); cerebellum: 88.9328% (minimum 99%, Missing); cerebral cortex: 74.5033% (minimum 99%, Missing); choroid plexus: 52.5701% (minimum 99%, Missing); colon: 81.2274% (minimum 97%, Missing); duodenum: 87.5486% (minimum 99%, Missing); esophagus: 71.4286% (minimum 97%, Missing); heart muscle: 69.2308% (minimum 99%, Missing); hippocampal formation: 73.2899% (minimum 99%, Missing); hypothalamus: 76.7918% (minimum 99%, Missing); kidney: 74.5033% (minimum 99%, Missing); liver: 85.5513% (minimum 99%, Missing); lung: 69.2308% (minimum 99%, Missing); lymph node: 72.8155% (minimum 97%, Missing); midbrain: 70.5329% (minimum 99%, Missing); pancreas: 75.7576% (minimum 99%, Missing); parathyroid gland: 69.2308% (minimum 97%, Missing); pituitary gland: 79.2254% (minimum 99%, Missing); rectum: 67.5676% (minimum 97%, Missing); retina: 59.2105% (minimum 99%, Missing); salivary gland: 75.7576% (minimum 97%, Missing); skeletal muscle: 55.4187% (minimum 99%, Missing); skin: 78.9474% (minimum 95%, Missing); small intestine: 79.2254% (minimum 99%, Missing); smooth muscle: 71.6561% (minimum 99%, Missing); spinal cord: 69.0184% (minimum 99%, Missing); spleen: 77.5862% (minimum 95%, Missing); stomach: 70.9779% (minimum 97%, Missing); thymus: 80.3571% (minimum 95%, Missing); thyroid gland: 51.2528% (minimum 95%, Missing); tongue: 80.6452% (minimum 97%, Missing); urinary bladder: 78.6713% (minimum 97%, Missing)",0,1,partial,20.3,10.8,21.4,"thyroid gland: 21.4 nTPM (manageable, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 2); rectum: 10.8 nTPM (protected, limit 2); spinal cord: 10.1 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 2); lung: 10 nTPM (vital, limit 1); adipose tissue: 9.5 nTPM (manageable, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 2); esophagus: 9 nTPM (protected, limit 2); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 2); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); salivary gland: 7.2 nTPM (protected, limit 2); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.1 nTPM (protected, limit 2); skin: 6 nTPM (manageable, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 2); colon: 5.2 nTPM (protected, limit 2); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000203666,EFCAB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.437472,-0.294324,-0.464299
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,25.1,3.5,4.6,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000203772,SPRN,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 47.3684% (minimum 99%, Baseline (adaptation disabled)); amygdala: 27.6923% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 29.2683% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 17.7340% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 12.5436% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.2973% (minimum 99%, Baseline (adaptation disabled)); colon: 61.0169% (minimum 97%, Baseline (adaptation disabled)); duodenum: 87.8049% (minimum 99%, Baseline (adaptation disabled)); esophagus: 56.2500% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.9245% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 21.3018% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 35.6436% (minimum 99%, Baseline (adaptation disabled)); kidney: 40.4494% (minimum 99%, Baseline (adaptation disabled)); liver: 17.2249% (minimum 99%, Baseline (adaptation disabled)); lung: 69.2308% (minimum 99%, Baseline (adaptation disabled)); midbrain: 45.5696% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.3846% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.7368% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 41.8605% (minimum 99%, Baseline (adaptation disabled)); retina: 85.7143% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.1579% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.4545% (minimum 99%, Baseline (adaptation disabled)); skin: 66.6667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 52.9412% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.3077% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 52.1739% (minimum 99%, Baseline (adaptation disabled)); spleen: 43.9024% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.7042% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 51.4286% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 69.2308% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,25.1,3.5,4.6,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000203772,SPRN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.510976,-0.462958,-0.864564
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.0000% (minimum 95%, Missing); adrenal gland: 47.3684% (minimum 99%, Missing); amygdala: 27.6923% (minimum 99%, Missing); basal ganglia: 29.2683% (minimum 99%, Missing); cerebellum: 17.7340% (minimum 99%, Missing); cerebral cortex: 12.5436% (minimum 99%, Missing); choroid plexus: 97.2973% (minimum 99%, Missing); colon: 61.0169% (minimum 97%, Missing); duodenum: 87.8049% (minimum 99%, Missing); esophagus: 56.2500% (minimum 97%, Missing); heart muscle: 67.9245% (minimum 99%, Missing); hippocampal formation: 21.3018% (minimum 99%, Missing); hypothalamus: 35.6436% (minimum 99%, Missing); kidney: 40.4494% (minimum 99%, Missing); liver: 17.2249% (minimum 99%, Missing); lung: 69.2308% (minimum 99%, Missing); midbrain: 45.5696% (minimum 99%, Missing); pancreas: 55.3846% (minimum 99%, Missing); parathyroid gland: 94.7368% (minimum 97%, Missing); pituitary gland: 41.8605% (minimum 99%, Missing); retina: 85.7143% (minimum 99%, Missing); salivary gland: 63.1579% (minimum 97%, Missing); skeletal muscle: 65.4545% (minimum 99%, Missing); skin: 66.6667% (minimum 95%, Missing); small intestine: 52.9412% (minimum 99%, Missing); smooth muscle: 92.3077% (minimum 99%, Missing); spinal cord: 52.1739% (minimum 99%, Missing); spleen: 43.9024% (minimum 95%, Missing); stomach: 50.7042% (minimum 97%, Missing); thyroid gland: 51.4286% (minimum 95%, Missing); urinary bladder: 69.2308% (minimum 97%, Missing)",0,80,unavailable,25.1,3.5,4.6,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); colon: 2.3 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000203772,SPRN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.510976,-0.462958,-0.864564
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,101.6,42,20.4,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 2); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); colon: 20.4 nTPM (protected, limit 2); urinary bladder: 18.4 nTPM (protected, limit 2); stomach: 18.1 nTPM (protected, limit 2); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (manageable, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 13.2 nTPM (vital, limit 1); thymus: 10.6 nTPM (manageable, limit 5); salivary gland: 8.7 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 2); rectum: 5.2 nTPM (protected, limit 2); spleen: 5.1 nTPM (manageable, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203778,FAM229B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.4008% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.4285% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.8156% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.9020% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.0890% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.0871% (minimum 99%, Baseline (adaptation disabled)); colon: 95.5263% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 86.5488% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.0330% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.1210% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.8793% (minimum 99%, Baseline (adaptation disabled)); liver: 94.7368% (minimum 99%, Baseline (adaptation disabled)); lung: 96.7140% (minimum 99%, Baseline (adaptation disabled)); midbrain: 82.8294% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1302% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.2060% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 87.1374% (minimum 99%, Baseline (adaptation disabled)); retina: 92.7006% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.0588% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.3740% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.0953% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.2990% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.0106% (minimum 97%, Baseline (adaptation disabled)); tongue: 96.7355% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.9471% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,101.6,42,20.4,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 2); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); colon: 20.4 nTPM (protected, limit 2); urinary bladder: 18.4 nTPM (protected, limit 2); stomach: 18.1 nTPM (protected, limit 2); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (manageable, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 13.2 nTPM (vital, limit 1); thymus: 10.6 nTPM (manageable, limit 5); salivary gland: 8.7 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 2); rectum: 5.2 nTPM (protected, limit 2); spleen: 5.1 nTPM (manageable, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203778,FAM229B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00526316,-0.0579397,-0.179129
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 95.4008% (minimum 99%, Missing); amygdala: 85.4285% (minimum 99%, Missing); basal ganglia: 85.8156% (minimum 99%, Missing); cerebellum: 94.9020% (minimum 99%, Missing); cerebral cortex: 88.0890% (minimum 99%, Missing); choroid plexus: 81.0871% (minimum 99%, Missing); colon: 95.5263% (minimum 97%, Missing); heart muscle: 86.5488% (minimum 99%, Missing); hippocampal formation: 87.0330% (minimum 99%, Missing); hypothalamus: 86.1210% (minimum 99%, Missing); kidney: 93.8793% (minimum 99%, Missing); liver: 94.7368% (minimum 99%, Missing); lung: 96.7140% (minimum 99%, Missing); midbrain: 82.8294% (minimum 99%, Missing); pancreas: 98.1302% (minimum 99%, Missing); parathyroid gland: 91.2060% (minimum 97%, Missing); pituitary gland: 87.1374% (minimum 99%, Missing); retina: 92.7006% (minimum 99%, Missing); skeletal muscle: 97.0588% (minimum 99%, Missing); small intestine: 98.3740% (minimum 99%, Missing); smooth muscle: 96.0953% (minimum 99%, Missing); spinal cord: 81.2990% (minimum 99%, Missing); stomach: 96.0106% (minimum 97%, Missing); tongue: 96.7355% (minimum 97%, Missing); urinary bladder: 95.9471% (minimum 97%, Missing)",0,80,unavailable,101.6,42,20.4,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 2); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); colon: 20.4 nTPM (protected, limit 2); urinary bladder: 18.4 nTPM (protected, limit 2); stomach: 18.1 nTPM (protected, limit 2); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (manageable, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 2); skeletal muscle: 13.2 nTPM (vital, limit 1); thymus: 10.6 nTPM (manageable, limit 5); salivary gland: 8.7 nTPM (protected, limit 2); pancreas: 8.3 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 2); rectum: 5.2 nTPM (protected, limit 2); spleen: 5.1 nTPM (manageable, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203778,FAM229B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00526316,-0.0579397,-0.179129
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,66.4,5.2,8,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); lung: 5.5 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 2); amygdala: 5.2 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); cerebral cortex: 2.9 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203780,FANK1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.0068% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.3478% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.1220% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.2111% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9189% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.9827% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 45.2597% (minimum 99%, Baseline (adaptation disabled)); colon: 94.8187% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.9790% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.0068% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.7410% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.8350% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.2484% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.5941% (minimum 99%, Baseline (adaptation disabled)); lung: 90.8940% (minimum 99%, Baseline (adaptation disabled)); midbrain: 92.7365% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.0508% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.7365% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.4058% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.4242% (minimum 97%, Baseline (adaptation disabled)); retina: 78.2051% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.9790% (minimum 97%, Baseline (adaptation disabled)); skin: 90.7438% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.4851% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.6868% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.4923% (minimum 99%, Baseline (adaptation disabled)); stomach: 91.3478% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 87.2814% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.1471% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,66.4,5.2,8,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); lung: 5.5 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 2); amygdala: 5.2 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); cerebral cortex: 2.9 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203780,FANK1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.077186,-0.0565225,-0.537403
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.0068% (minimum 99%, Missing); amygdala: 91.3478% (minimum 99%, Missing); basal ganglia: 88.1220% (minimum 99%, Missing); bone marrow: 98.2111% (minimum 99%, Missing); cerebellum: 98.9189% (minimum 99%, Missing); cerebral cortex: 94.9827% (minimum 99%, Missing); choroid plexus: 45.2597% (minimum 99%, Missing); colon: 94.8187% (minimum 97%, Missing); duodenum: 95.9790% (minimum 99%, Missing); esophagus: 94.0068% (minimum 97%, Missing); heart muscle: 98.7410% (minimum 99%, Missing); hippocampal formation: 88.8350% (minimum 99%, Missing); hypothalamus: 85.2484% (minimum 99%, Missing); kidney: 90.5941% (minimum 99%, Missing); lung: 90.8940% (minimum 99%, Missing); midbrain: 92.7365% (minimum 99%, Missing); pancreas: 93.0508% (minimum 99%, Missing); parathyroid gland: 92.7365% (minimum 97%, Missing); pituitary gland: 88.4058% (minimum 99%, Missing); rectum: 92.4242% (minimum 97%, Missing); retina: 78.2051% (minimum 99%, Missing); salivary gland: 95.9790% (minimum 97%, Missing); skin: 90.7438% (minimum 95%, Missing); small intestine: 96.4851% (minimum 99%, Missing); smooth muscle: 97.6868% (minimum 99%, Missing); spinal cord: 94.4923% (minimum 99%, Missing); stomach: 91.3478% (minimum 97%, Missing); thyroid gland: 87.2814% (minimum 95%, Missing); urinary bladder: 96.1471% (minimum 97%, Missing)",0,80,unavailable,66.4,5.2,8,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); lung: 5.5 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 2); amygdala: 5.2 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 2); pancreas: 4.1 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 2); spinal cord: 3.2 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); cerebral cortex: 2.9 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); urinary bladder: 2.2 nTPM (protected, limit 2); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203780,FANK1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.077186,-0.0565225,-0.537403
True,compatible,,True,True,False,,0,1,partial,0.4,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000203784,LELP1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.4,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000203784,LELP1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.049724,0.029908,0.00963201
True,compatible,,True,True,True,,0,1,partial,0.4,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000203784,LELP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.049908,0.03,0.00990798
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000203795,FAM24A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000203795,FAM24A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000203795,FAM24A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,8.4,0.4,4.3,"small intestine: 8.4 nTPM (vital, limit 3); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000203857,HSD3B1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.4293% (minimum 99%, Baseline (adaptation disabled)); liver: 98.4293% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.5583% (minimum 99%, Baseline (adaptation disabled)); skin: 94.5912% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.9522% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,8.4,0.4,4.3,"small intestine: 8.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000203857,HSD3B1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.00408805,0.024709,-0.0904785
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.4293% (minimum 99%, Missing); small intestine: 89.9522% (minimum 97%, Supported)",0,5,partial,8.4,0.4,4.3,"small intestine: 8.4 nTPM (vital, limit 3); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000203857,HSD3B1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.0704785
True,compatible,,True,True,False,,0,4,partial,0.9,1.7,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000203907,OOEP,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.5714% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.5035% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.1831% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8723% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5714% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.8776% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.0323% (minimum 97%, Baseline (adaptation disabled)); skin: 93.8776% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.5035% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,0.9,1.7,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000203907,OOEP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025,-0.0112245,-0.0796774,-0.0512245
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 96.5035% (minimum 99%, Missing); kidney: 97.1831% (minimum 98%, Approved); liver: 97.8723% (minimum 98%, Approved); pancreas: 93.8776% (minimum 98%, Approved); salivary gland: 89.0323% (minimum 95%, Approved)",0,4,partial,0.9,1.7,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000203907,OOEP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Bruggeman 2018;Loriot 2025,0.0387755,-0.0596774,-0.0412245
True,compatible,,True,True,False,,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000203909,DPPA5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 95.2381% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000203909,DPPA5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.00238095,0.03,-0.19
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 95.2381% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing)",0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000203909,DPPA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.00238095,0.03,-0.19
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2,0.2,0.6,"retina: 2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin,ENSG00000203910,C1orf146,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.6486% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6486% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.3333% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.0526% (minimum 99%, Baseline (adaptation disabled)); retina: 78.4946% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.6486% (minimum 99%, Baseline (adaptation disabled)); skin: 92.4051% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2,0.2,0.6,"retina: 2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin,ENSG00000203910,C1orf146,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0259494,0.00333333,-0.205054
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.6486% (minimum 99%, Missing); cerebellum: 98.6486% (minimum 99%, Missing); cerebral cortex: 97.3333% (minimum 99%, Missing); pancreas: 96.0526% (minimum 99%, Missing); retina: 78.4946% (minimum 99%, Missing); skeletal muscle: 98.6486% (minimum 99%, Missing); skin: 92.4051% (minimum 95%, Missing)",0,80,unavailable,2,0.2,0.6,"retina: 2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin,ENSG00000203910,C1orf146,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0259494,0.00333333,-0.205054
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000203923,SPANXN1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000203923,SPANXN1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000203923,SPANXN1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000203926,SPANXA2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000203926,SPANXA2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000203926,SPANXA2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000203933,CXorf66,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 95.5882% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000203933,CXorf66,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0341176
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 95.5882% (minimum 99%, Missing)",0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000203933,CXorf66,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0341176
True,compatible,,True,True,False,,0,5,partial,0.8,0.2,0.1,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000203942,C10orf62,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,5,partial,0.8,0.2,0.1,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000203942,C10orf62,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.04963,0.0292604,0.00704797
True,compatible,,True,True,True,,0,5,partial,0.8,0.2,0.1,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000203942,C10orf62,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.0292604,0.00815294
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.1,0.1,0,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000203963,C1orf141,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.1290% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.3038% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.0263% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.6591% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.5128% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.3038% (minimum 99%, Baseline (adaptation disabled)); lung: 93.7107% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.0263% (minimum 99%, Baseline (adaptation disabled)); retina: 82.7778% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.6755% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.1,0.1,0,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000203963,C1orf141,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.0233333,-0.162222
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.1290% (minimum 99%, Missing); basal ganglia: 94.3038% (minimum 99%, Missing); cerebral cortex: 98.0263% (minimum 99%, Missing); choroid plexus: 84.6591% (minimum 99%, Missing); hippocampal formation: 95.5128% (minimum 99%, Missing); hypothalamus: 94.3038% (minimum 99%, Missing); lung: 93.7107% (minimum 99%, Missing); midbrain: 98.0263% (minimum 99%, Missing); retina: 82.7778% (minimum 99%, Missing); spinal cord: 98.6755% (minimum 99%, Missing)",0,80,unavailable,3.1,0.1,0,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000203963,C1orf141,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.0233333,-0.162222
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000203970,DEFB110,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000203970,DEFB110,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000203970,DEFB110,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000203989,RHOXF2B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000203989,RHOXF2B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00516908
True,compatible,,True,True,True,,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,ENSG00000203989,RHOXF2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.8,0.6,2.2,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203995,ZYG11A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.3684% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.8718% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 92.5000% (minimum 99%, Baseline (adaptation disabled)); duodenum: 94.8718% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.0465% (minimum 97%, Baseline (adaptation disabled)); kidney: 56.9231% (minimum 99%, Baseline (adaptation disabled)); liver: 75.5102% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.8718% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.3684% (minimum 99%, Baseline (adaptation disabled)); retina: 94.8718% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.3684% (minimum 99%, Baseline (adaptation disabled)); skin: 94.8718% (minimum 95%, Baseline (adaptation disabled)); thymus: 92.5000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.7119% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2.8,0.6,2.2,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203995,ZYG11A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.322881,-0.109535,-0.420769
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.3684% (minimum 99%, Missing); cerebellum: 94.8718% (minimum 99%, Missing); choroid plexus: 92.5000% (minimum 99%, Missing); duodenum: 94.8718% (minimum 99%, Missing); esophagus: 86.0465% (minimum 97%, Missing); kidney: 56.9231% (minimum 99%, Missing); liver: 75.5102% (minimum 99%, Missing); lymph node: 94.8718% (minimum 97%, Missing); pituitary gland: 97.3684% (minimum 99%, Missing); retina: 94.8718% (minimum 99%, Missing); skeletal muscle: 97.3684% (minimum 99%, Missing); skin: 94.8718% (minimum 95%, Missing); thymus: 92.5000% (minimum 95%, Missing); thyroid gland: 62.7119% (minimum 95%, Missing)",0,80,unavailable,2.8,0.6,2.2,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000203995,ZYG11A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.322881,-0.109535,-0.420769
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.1,,,0,not_established,not_triggered,,,ENSG00000204006,C1orf185,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,not_triggered,,,ENSG00000204006,C1orf185,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0459677,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,not_triggered,,,ENSG00000204006,C1orf185,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0459677,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204007,GLT6D1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204007,GLT6D1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204007,GLT6D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0,2.6,0,"salivary gland: 2.6 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000204019,CT83,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 95.9877% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0,2.6,0,"salivary gland: 2.6 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000204019,CT83,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,-0.0101235,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 95.9877% (minimum 97%, Missing)",0,80,unavailable,0,2.6,0,"salivary gland: 2.6 nTPM (protected, limit 2)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000204019,CT83,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,-0.0101235,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204022,LIPJ,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.5507% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5507% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.1507% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.1429% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.1429% (minimum 99%, Baseline (adaptation disabled)); duodenum: 95.7746% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5507% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.1429% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.1429% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.1429% (minimum 99%, Baseline (adaptation disabled)); liver: 93.1507% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5507% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.7746% (minimum 97%, Baseline (adaptation disabled)); pancreas: 95.7746% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.5507% (minimum 99%, Baseline (adaptation disabled)); retina: 98.5507% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.7746% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.1429% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5507% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.1429% (minimum 99%, Baseline (adaptation disabled)); thymus: 94.4444% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 93.1507% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204022,LIPJ,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0184932,-0.0122535,-0.0584932
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.5507% (minimum 99%, Missing); basal ganglia: 98.5507% (minimum 99%, Missing); cerebellum: 93.1507% (minimum 99%, Missing); cerebral cortex: 97.1429% (minimum 99%, Missing); choroid plexus: 97.1429% (minimum 99%, Missing); duodenum: 95.7746% (minimum 99%, Missing); heart muscle: 98.5507% (minimum 99%, Missing); hippocampal formation: 97.1429% (minimum 99%, Missing); hypothalamus: 97.1429% (minimum 99%, Missing); kidney: 97.1429% (minimum 99%, Missing); liver: 93.1507% (minimum 99%, Missing); lung: 98.5507% (minimum 99%, Missing); lymph node: 95.7746% (minimum 97%, Missing); pancreas: 95.7746% (minimum 99%, Missing); pituitary gland: 98.5507% (minimum 99%, Missing); retina: 98.5507% (minimum 99%, Missing); salivary gland: 95.7746% (minimum 97%, Missing); skeletal muscle: 97.1429% (minimum 99%, Missing); small intestine: 98.5507% (minimum 99%, Missing); smooth muscle: 97.1429% (minimum 99%, Missing); thymus: 94.4444% (minimum 95%, Missing); thyroid gland: 93.1507% (minimum 95%, Missing)",0,80,unavailable,0.5,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204022,LIPJ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0184932,-0.0122535,-0.0584932
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000204025,TRPC5OS,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000204025,TRPC5OS,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.000521327
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000204025,TRPC5OS,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.000521327
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,12,partial,12.5,3.5,1,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 6); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000204052,LRRC73,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.3984% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.8283% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.4394% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.9227% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.4775% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.7551% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.3982% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.6292% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.6576% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.6598% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.5055% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8506% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1735% (minimum 99%, Baseline (adaptation disabled)); midbrain: 93.8865% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.5057% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.4731% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.3361% (minimum 99%, Baseline (adaptation disabled)); retina: 96.6292% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.1735% (minimum 99%, Baseline (adaptation disabled))",0,12,partial,12.5,3.5,1,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 2); midbrain: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000204052,LRRC73,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0272727,-0.0452688,-0.215225
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 87.3984% (minimum 95%, Enhanced); amygdala: 85.8283% (minimum 99%, Missing); basal ganglia: 81.4394% (minimum 99%, Missing); cerebellum: 94.9227% (minimum 99%, Missing); cerebral cortex: 77.4775% (minimum 99%, Missing); choroid plexus: 87.7551% (minimum 99%, Missing); hippocampal formation: 83.6576% (minimum 99%, Missing); hypothalamus: 88.6598% (minimum 99%, Missing); kidney: 94.5055% (minimum 95%, Enhanced); midbrain: 93.8865% (minimum 99%, Missing); pituitary gland: 90.3361% (minimum 99%, Missing); retina: 96.6292% (minimum 99%, Missing); spinal cord: 98.1735% (minimum 99%, Missing)",0,12,partial,12.5,3.5,1,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 6); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,ENSG00000204052,LRRC73,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0207834,-0.215225
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,0.4,0.2,0.4,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000204086,RPA4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.1176% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.8889% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 94.1176% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.1176% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.1176% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.2105% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.1176% (minimum 99%, Baseline (adaptation disabled)); liver: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 84.2105% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.1176% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.1176% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 94.1176% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); skin: 94.1176% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.1176% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.1176% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.1176% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.1176% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 94.1176% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 88.8889% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,0.4,0.2,0.4,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000204086,RPA4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.15,-0.0811111,-0.19
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 94.1176% (minimum 99%, Missing); bone marrow: 88.8889% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 94.1176% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); esophagus: 94.1176% (minimum 97%, Missing); heart muscle: 84.2105% (minimum 99%, Missing); kidney: 94.1176% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lung: 84.2105% (minimum 99%, Missing); pancreas: 94.1176% (minimum 99%, Missing); rectum: 94.1176% (minimum 97%, Missing); salivary gland: 94.1176% (minimum 97%, Missing); skeletal muscle: 88.8889% (minimum 99%, Missing); skin: 94.1176% (minimum 95%, Missing); small intestine: 94.1176% (minimum 99%, Missing); spinal cord: 94.1176% (minimum 99%, Missing); spleen: 94.1176% (minimum 95%, Missing); stomach: 94.1176% (minimum 97%, Missing); thyroid gland: 94.1176% (minimum 95%, Missing); urinary bladder: 88.8889% (minimum 97%, Missing)",0,2,partial,0.4,0.2,0.4,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000204086,RPA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.15,-0.0811111,-0.19
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,173.3,1.5,0.1,"pancreas: 173.3 nTPM (vital, limit 6); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000204140,CLPSL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 77.3553% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,173.3,1.5,0.1,"pancreas: 173.3 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000204140,CLPSL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0498311,0.0274726,-0.216447
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 77.3553% (minimum 95%, Enhanced)",0,1,partial,173.3,1.5,0.1,"pancreas: 173.3 nTPM (vital, limit 6); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000204140,CLPSL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.176447
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.2,2.2,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000204165,CXorf65,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.3214% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1982% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.1965% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.8333% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.2,2.2,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000204165,CXorf65,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0416667,0.0209091,-0.0380349
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 97.3214% (minimum 99%, Missing); lung: 98.1982% (minimum 99%, Missing); small intestine: 95.1965% (minimum 99%, Missing); spleen: 90.8333% (minimum 95%, Missing)",0,80,unavailable,1.1,0.2,2.2,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000204165,CXorf65,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0416667,0.0209091,-0.0380349
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000204193,TXNDC8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000204193,TXNDC8,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0453271,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000204193,TXNDC8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0453271,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204246,OR13C3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204246,OR13C3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204246,OR13C3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204279,PAGE3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204279,PAGE3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204279,PAGE3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0.1,0.2,0.1,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000204296,TSBP1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0.2,0.1,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000204296,TSBP1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.0470326,0.0240828,0.00703264
True,compatible,,True,True,True,,0,1,partial,0.1,0.2,0.1,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000204296,TSBP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204300,TMEM225,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204300,TMEM225,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204300,TMEM225,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.2,2.7,4.1,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204311,PJVK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.1695% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.4089% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.3721% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.8065% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.6620% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.2617% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.6478% (minimum 99%, Baseline (adaptation disabled)); colon: 90.7850% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.6835% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.9929% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.7888% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.3721% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.6450% (minimum 99%, Baseline (adaptation disabled)); liver: 86.9281% (minimum 99%, Baseline (adaptation disabled)); lung: 94.3262% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.6620% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.0841% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.3262% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.0289% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 82.3529% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.0289% (minimum 97%, Baseline (adaptation disabled)); retina: 81.0976% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 91.0959% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.9632% (minimum 99%, Baseline (adaptation disabled)); skin: 86.6450% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.9929% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.5000% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.6620% (minimum 95%, Baseline (adaptation disabled)); stomach: 93.6620% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 88.0795% (minimum 95%, Baseline (adaptation disabled)); tongue: 96.7273% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 91.0959% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.2,2.7,4.1,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204311,PJVK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0835505,-0.0621502,-0.179024
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 90.1695% (minimum 95%, Missing); adrenal gland: 91.4089% (minimum 99%, Missing); amygdala: 88.3721% (minimum 99%, Missing); basal ganglia: 85.8065% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 93.6620% (minimum 99%, Missing); cerebral cortex: 89.2617% (minimum 99%, Missing); choroid plexus: 83.6478% (minimum 99%, Missing); colon: 90.7850% (minimum 97%, Missing); duodenum: 95.6835% (minimum 99%, Missing); esophagus: 93.9929% (minimum 97%, Missing); heart muscle: 93.3333% (minimum 99%, Missing); hippocampal formation: 87.7888% (minimum 99%, Missing); hypothalamus: 88.3721% (minimum 99%, Missing); kidney: 86.6450% (minimum 99%, Missing); liver: 86.9281% (minimum 99%, Missing); lung: 94.3262% (minimum 99%, Missing); lymph node: 93.6620% (minimum 97%, Missing); midbrain: 86.0841% (minimum 99%, Missing); pancreas: 94.3262% (minimum 99%, Missing); parathyroid gland: 96.0289% (minimum 97%, Missing); pituitary gland: 82.3529% (minimum 99%, Missing); rectum: 96.0289% (minimum 97%, Missing); retina: 81.0976% (minimum 99%, Missing); salivary gland: 91.0959% (minimum 97%, Missing); skeletal muscle: 88.9632% (minimum 99%, Missing); skin: 86.6450% (minimum 95%, Missing); small intestine: 93.9929% (minimum 99%, Missing); smooth muscle: 93.3333% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 93.6620% (minimum 95%, Missing); stomach: 93.6620% (minimum 97%, Missing); thyroid gland: 88.0795% (minimum 95%, Missing); tongue: 96.7273% (minimum 97%, Missing); urinary bladder: 91.0959% (minimum 97%, Missing)",0,80,unavailable,6.2,2.7,4.1,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204311,PJVK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0835505,-0.0621502,-0.179024
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,46.7,6.3,10.4,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); tongue: 2.4 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000204334,ERICH2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6386% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.5520% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.9115% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.6118% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.3411% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.3344% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2132% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.3138% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.7315% (minimum 99%, Baseline (adaptation disabled)); liver: 97.9717% (minimum 99%, Baseline (adaptation disabled)); lung: 94.4873% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.7315% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.6118% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.1979% (minimum 97%, Baseline (adaptation disabled)); retina: 96.6646% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.6386% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 93.8751% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,46.7,6.3,10.4,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); tongue: 2.4 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000204334,ERICH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.0112485,-0.00802052,-0.216589
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6386% (minimum 99%, Missing); amygdala: 97.5520% (minimum 99%, Missing); basal ganglia: 97.9115% (minimum 99%, Missing); cerebral cortex: 97.6118% (minimum 99%, Missing); choroid plexus: 77.3411% (minimum 99%, Missing); heart muscle: 98.3344% (minimum 99%, Missing); hippocampal formation: 98.2132% (minimum 99%, Missing); hypothalamus: 97.3138% (minimum 99%, Missing); kidney: 97.7315% (minimum 99%, Missing); liver: 97.9717% (minimum 99%, Missing); lung: 94.4873% (minimum 99%, Missing); midbrain: 97.7315% (minimum 99%, Missing); pancreas: 97.6118% (minimum 99%, Missing); parathyroid gland: 96.1979% (minimum 97%, Missing); retina: 96.6646% (minimum 99%, Missing); spinal cord: 98.6386% (minimum 99%, Missing); thyroid gland: 93.8751% (minimum 95%, Missing)",0,80,unavailable,46.7,6.3,10.4,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 2); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); stomach: 2.8 nTPM (protected, limit 2); heart muscle: 2.7 nTPM (vital, limit 1); salivary gland: 2.6 nTPM (protected, limit 2); tongue: 2.4 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000204334,ERICH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.0112485,-0.00802052,-0.216589
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204363,SPANXN5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204363,SPANXN5,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204363,SPANXN5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000204379,XAGE1A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000204379,XAGE1A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.0478166,0.0278166,0.00781659
True,compatible,,True,True,True,,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,ENSG00000204379,XAGE1A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.0478166,0.0278166,0.00781659
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,0.5,0.6,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000204382,XAGE1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 97.2527% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7901% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.5,0.5,0.6,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000204382,XAGE1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,0.0388268,0.0206716,-0.0174725
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 97.2527% (minimum 99%, Missing); lung: 97.7901% (minimum 99%, Missing)",0,80,unavailable,1.5,0.5,0.6,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000204382,XAGE1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,0.0388268,0.0206716,-0.0174725
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,3.8,1.7,2.4,"basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000204390,HSPA1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.7707% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.4899% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.0464% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.9375% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.8995% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.7707% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.0876% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.2382% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.7707% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0831% (minimum 99%, Baseline (adaptation disabled)); lung: 97.9266% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.7878% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.5554% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.3059% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 94.1718% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.7707% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.3416% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,3.8,1.7,2.4,"skeletal muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000204390,HSPA1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0123824,0.00305864,-0.0482822
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.4899% (minimum 99%, Missing); basal ganglia: 95.0464% (minimum 99%, Missing); cerebral cortex: 94.8995% (minimum 95%, Enhanced); hippocampal formation: 96.0876% (minimum 99%, Missing); hypothalamus: 96.2382% (minimum 99%, Missing); midbrain: 95.7878% (minimum 99%, Missing); pituitary gland: 97.3059% (minimum 99%, Missing); skeletal muscle: 94.1718% (minimum 95%, Enhanced); spinal cord: 95.3416% (minimum 99%, Missing)",0,4,partial,3.8,1.7,2.4,"basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000204390,HSPA1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,0.028374,-0.0395356
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,3,partial,0.8,0.3,0.2,,pituitary gland / cells in anterior : High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,ENSG00000204414,CSHL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,3,partial,0.8,0.3,0.2,,pituitary gland / cells in anterior : High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,ENSG00000204414,CSHL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0486254,0.0279396,0.0045243
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,3,partial,0.8,0.3,0.2,,pituitary gland / cells in anterior : High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,ENSG00000204414,CSHL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0486254,0.03,0.0045243
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204449,TRIM49C,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204449,TRIM49C,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204449,TRIM49C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204478,PRAMEF20,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204478,PRAMEF20,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204478,PRAMEF20,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000204480,PRAMEF19,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000204480,PRAMEF19,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000204480,PRAMEF19,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204481,PRAMEF14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204481,PRAMEF14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204481,PRAMEF14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000204501,PRAMEF15,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000204501,PRAMEF15,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000204501,PRAMEF15,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,32.1,0.5,0.3,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000204505,PRAMEF9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 80.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.0000% (minimum 99%, Baseline (adaptation disabled)); duodenum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 44.4444% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 40.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); pancreas: 80.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 57.1429% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 1.2308% (minimum 99%, Baseline (adaptation disabled)); skin: 57.1429% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 80.0000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 57.1429% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 80.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,32.1,0.5,0.3,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000204505,PRAMEF9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.378571,-0.525556,-0.977692
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 66.6667% (minimum 95%, Missing); bone marrow: 80.0000% (minimum 99%, Missing); cerebral cortex: 80.0000% (minimum 99%, Missing); duodenum: 80.0000% (minimum 99%, Missing); esophagus: 44.4444% (minimum 97%, Missing); heart muscle: 40.0000% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); pancreas: 80.0000% (minimum 99%, Missing); retina: 57.1429% (minimum 99%, Missing); salivary gland: 80.0000% (minimum 97%, Missing); skeletal muscle: 1.2308% (minimum 99%, Missing); skin: 57.1429% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); spleen: 66.6667% (minimum 95%, Missing); stomach: 80.0000% (minimum 97%, Missing); thyroid gland: 57.1429% (minimum 95%, Missing); urinary bladder: 80.0000% (minimum 97%, Missing)",0,80,unavailable,32.1,0.5,0.3,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000204505,PRAMEF9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.378571,-0.525556,-0.977692
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,6.6,2.1,2.1,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000204524,ZNF805,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 52.5000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 84.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 80.7692% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 24.1379% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.7778% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 65.6250% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 63.6364% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.7419% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.6250% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 58.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.7647% (minimum 99%, Baseline (adaptation disabled)); liver: 52.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 58.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 58.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 80.7692% (minimum 99%, Baseline (adaptation disabled)); pancreas: 61.7647% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.7647% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 44.6809% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.2632% (minimum 99%, Baseline (adaptation disabled)); skin: 52.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.6250% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.2632% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.7778% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 58.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.7568% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.7568% (minimum 95%, Baseline (adaptation disabled)); tongue: 51.2195% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.7647% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,6.6,2.1,2.1,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000204524,ZNF805,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.47,-0.748621
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.3333% (minimum 95%, Uncertain); adrenal gland: 52.5000% (minimum 99%, Missing); amygdala: 84.0000% (minimum 99%, Missing); basal ganglia: 80.7692% (minimum 99%, Missing); bone marrow: 24.1379% (minimum 99%, Missing); cerebellum: 77.7778% (minimum 99%, Missing); cerebral cortex: 65.6250% (minimum 99%, Missing); choroid plexus: 60.0000% (minimum 99%, Missing); colon: 63.6364% (minimum 97%, Missing); duodenum: 67.7419% (minimum 99%, Missing); esophagus: 65.6250% (minimum 97%, Missing); heart muscle: 58.3333% (minimum 99%, Missing); hippocampal formation: 84.0000% (minimum 99%, Missing); hypothalamus: 84.0000% (minimum 99%, Missing); kidney: 61.7647% (minimum 99%, Missing); liver: 52.5000% (minimum 99%, Missing); lung: 58.3333% (minimum 99%, Missing); lymph node: 58.3333% (minimum 97%, Missing); midbrain: 80.7692% (minimum 99%, Missing); pancreas: 61.7647% (minimum 99%, Missing); parathyroid gland: 50.0000% (minimum 97%, Missing); pituitary gland: 61.7647% (minimum 99%, Missing); rectum: 58.3333% (minimum 97%, Missing); retina: 44.6809% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 97%, Missing); skeletal muscle: 55.2632% (minimum 99%, Missing); skin: 52.5000% (minimum 95%, Missing); small intestine: 65.6250% (minimum 99%, Missing); smooth muscle: 55.2632% (minimum 99%, Missing); spinal cord: 77.7778% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 58.3333% (minimum 97%, Missing); thymus: 56.7568% (minimum 95%, Missing); thyroid gland: 56.7568% (minimum 95%, Missing); tongue: 51.2195% (minimum 97%, Missing); urinary bladder: 61.7647% (minimum 97%, Missing)",0,7,partial,6.6,2.1,2.1,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000204524,ZNF805,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.47,-0.748621
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,19.1,15.7,16.9,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 2); thyroid gland: 15.6 nTPM (manageable, limit 5); esophagus: 14.7 nTPM (protected, limit 2); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); urinary bladder: 12.9 nTPM (protected, limit 2); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); salivary gland: 11.1 nTPM (protected, limit 2); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); hypothalamus: 9.6 nTPM (vital, limit 1); duodenum: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204536,CCHCR1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.0441% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.8736% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.5596% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.7885% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.9401% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.9800% (minimum 99%, Baseline (adaptation disabled)); colon: 89.5889% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3656% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.1869% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.2814% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.9499% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.3656% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.6135% (minimum 99%, Baseline (adaptation disabled)); liver: 91.9048% (minimum 99%, Baseline (adaptation disabled)); lung: 93.9499% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.2079% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.2777% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.5496% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.7543% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.4077% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.8985% (minimum 99%, Baseline (adaptation disabled)); skin: 88.8816% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.4284% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.9019% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.9403% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.2221% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.9152% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 89.6483% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 91.2838% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,19.1,15.7,16.9,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 2); thyroid gland: 15.6 nTPM (manageable, limit 5); esophagus: 14.7 nTPM (protected, limit 2); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); urinary bladder: 12.9 nTPM (protected, limit 2); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); salivary gland: 11.1 nTPM (protected, limit 2); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); hypothalamus: 9.6 nTPM (vital, limit 1); duodenum: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204536,CCHCR1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0611842,-0.0741114,-0.113865
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.0441% (minimum 95%, Missing); adrenal gland: 94.8736% (minimum 99%, Missing); amygdala: 93.5596% (minimum 99%, Missing); basal ganglia: 92.7885% (minimum 99%, Missing); cerebellum: 88.9401% (minimum 99%, Missing); cerebral cortex: 92.9800% (minimum 99%, Missing); colon: 89.5889% (minimum 97%, Missing); duodenum: 93.3656% (minimum 99%, Missing); esophagus: 90.1869% (minimum 97%, Missing); heart muscle: 92.2814% (minimum 99%, Missing); hippocampal formation: 93.9499% (minimum 99%, Missing); hypothalamus: 93.3656% (minimum 99%, Missing); kidney: 87.6135% (minimum 99%, Missing); liver: 91.9048% (minimum 99%, Missing); lung: 93.9499% (minimum 99%, Missing); lymph node: 95.2079% (minimum 97%, Missing); midbrain: 94.2777% (minimum 99%, Missing); pancreas: 90.5496% (minimum 99%, Missing); pituitary gland: 93.7543% (minimum 99%, Missing); salivary gland: 92.4077% (minimum 97%, Missing); skeletal muscle: 87.8985% (minimum 99%, Missing); skin: 88.8816% (minimum 95%, Missing); small intestine: 90.4284% (minimum 99%, Missing); smooth muscle: 98.9019% (minimum 99%, Missing); spinal cord: 94.9403% (minimum 99%, Missing); spleen: 91.2221% (minimum 95%, Missing); stomach: 90.9152% (minimum 97%, Missing); thyroid gland: 89.6483% (minimum 95%, Missing); urinary bladder: 91.2838% (minimum 97%, Missing)",0,80,unavailable,19.1,15.7,16.9,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 2); thyroid gland: 15.6 nTPM (manageable, limit 5); esophagus: 14.7 nTPM (protected, limit 2); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 2); spleen: 13 nTPM (manageable, limit 5); urinary bladder: 12.9 nTPM (protected, limit 2); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); salivary gland: 11.1 nTPM (protected, limit 2); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); hypothalamus: 9.6 nTPM (vital, limit 1); duodenum: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204536,CCHCR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0611842,-0.0741114,-0.113865
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.8,1.5,3.2,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000204540,PSORS1C1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8889% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.9805% (minimum 99%, Baseline (adaptation disabled)); lung: 98.4332% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.3425% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.8,1.5,3.2,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000204540,PSORS1C1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0209091,0.0161496,-0.00657459
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.8889% (minimum 99%, Missing); cerebral cortex: 98.9805% (minimum 99%, Missing); lung: 98.4332% (minimum 99%, Missing); small intestine: 98.3425% (minimum 99%, Missing)",0,80,unavailable,1.8,1.5,3.2,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000204540,PSORS1C1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0209091,0.0161496,-0.00657459
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000204548,DEFB121,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000204548,DEFB121,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000204548,DEFB121,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,2,0,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000204614,TRIM40,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 41.1765% (minimum 97%, Baseline (adaptation disabled)); kidney: 87.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 48.2759% (minimum 99%, Baseline (adaptation disabled)); small intestine: 32.5581% (minimum 99%, Baseline (adaptation disabled)); stomach: 93.3333% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,2,0,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000204614,TRIM40,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,-0.558235,-0.664419
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 41.1765% (minimum 97%, Missing); kidney: 87.5000% (minimum 99%, Missing); liver: 48.2759% (minimum 99%, Missing); small intestine: 32.5581% (minimum 99%, Missing); stomach: 93.3333% (minimum 97%, Missing)",0,80,unavailable,2.9,2,0,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,ENSG00000204614,TRIM40,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,-0.558235,-0.664419
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.8,0.1,0,,,0,not_established,not_triggered,,,ENSG00000204640,NMS,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"hypothalamus: 27.2727% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 42.8571% (minimum 99%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.1,0,,,0,not_established,not_triggered,,,ENSG00000204640,NMS,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.22,-0.717273
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"hypothalamus: 27.2727% (minimum 99%, Missing); spinal cord: 42.8571% (minimum 99%, Missing); tongue: 75.0000% (minimum 97%, Missing)",0,80,unavailable,0.8,0.1,0,,,0,not_established,not_triggered,,,ENSG00000204640,NMS,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.22,-0.717273
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3,0.6,0.6,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000204659,CBY3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.4026% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.3614% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.9091% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.1677% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.7500% (minimum 99%, Baseline (adaptation disabled)); colon: 96.1538% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.4026% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.3614% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.8204% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.0392% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6842% (minimum 99%, Baseline (adaptation disabled)); lung: 98.6842% (minimum 99%, Baseline (adaptation disabled)); midbrain: 84.2697% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.3396% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.3396% (minimum 99%, Baseline (adaptation disabled)); retina: 97.4026% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.7742% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.4026% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.7742% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 83.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3,0.6,0.6,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000204659,CBY3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0115385,-0.00846154,-0.156667
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.4026% (minimum 99%, Missing); amygdala: 90.3614% (minimum 99%, Missing); basal ganglia: 90.9091% (minimum 99%, Missing); cerebellum: 93.1677% (minimum 99%, Missing); cerebral cortex: 93.7500% (minimum 99%, Missing); colon: 96.1538% (minimum 97%, Missing); heart muscle: 97.4026% (minimum 99%, Missing); hippocampal formation: 90.3614% (minimum 99%, Missing); hypothalamus: 89.8204% (minimum 99%, Missing); kidney: 98.0392% (minimum 99%, Missing); liver: 98.6842% (minimum 99%, Missing); lung: 98.6842% (minimum 99%, Missing); midbrain: 84.2697% (minimum 99%, Missing); pancreas: 94.3396% (minimum 99%, Missing); pituitary gland: 94.3396% (minimum 99%, Missing); retina: 97.4026% (minimum 99%, Missing); salivary gland: 96.7742% (minimum 97%, Missing); skeletal muscle: 97.4026% (minimum 99%, Missing); small intestine: 96.7742% (minimum 99%, Missing); spinal cord: 83.3333% (minimum 99%, Missing)",0,80,unavailable,3,0.6,0.6,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000204659,CBY3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0115385,-0.00846154,-0.156667
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,False,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000204661,SPATA31J1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000204661,SPATA31J1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000204661,SPATA31J1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000204669,C9orf57,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000204669,C9orf57,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.0021875
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000204669,C9orf57,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.0021875
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204671,IL31,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204671,IL31,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204671,IL31,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204688,OR2H1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204688,OR2H1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204688,OR2H1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204694,OR11A1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204694,OR11A1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204694,OR11A1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,1.8,0.3,0.7,"retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204695,OR14J1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 40.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.7143% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 54.5455% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); pancreas: 85.7143% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.7143% (minimum 97%, Baseline (adaptation disabled)); retina: 25.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 46.1538% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 85.7143% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.7143% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 85.7143% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.8,0.3,0.7,"retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204695,OR14J1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.488462,-0.303333,-0.74
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 75.0000% (minimum 99%, Missing); bone marrow: 40.0000% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 85.7143% (minimum 97%, Missing); heart muscle: 85.7143% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 54.5455% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); pancreas: 85.7143% (minimum 99%, Missing); rectum: 85.7143% (minimum 97%, Missing); retina: 25.0000% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 60.0000% (minimum 99%, Missing); skin: 46.1538% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 85.7143% (minimum 99%, Missing); spleen: 60.0000% (minimum 95%, Missing); stomach: 66.6667% (minimum 97%, Missing); thymus: 85.7143% (minimum 95%, Missing); thyroid gland: 75.0000% (minimum 95%, Missing); urinary bladder: 85.7143% (minimum 97%, Missing)",0,80,unavailable,1.8,0.3,0.7,"retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204695,OR14J1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.488462,-0.303333,-0.74
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000204700,OR2J2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 66.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000204700,OR2J2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.15,0.03,-0.323333
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 66.6667% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing)",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000204700,OR2J2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.15,0.03,-0.323333
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000204701,OR2J3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 75.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000204701,OR2J3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.24
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 75.0000% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000204701,OR2J3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.24
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204704,OR2W1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204704,OR2W1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204704,OR2W1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.3,0.8,1,"pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000204764,RANBP17,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 92.8571% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.8571% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.8571% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.2500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.4706% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.4706% (minimum 99%, Baseline (adaptation disabled)); colon: 86.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.6667% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 86.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.8571% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.4706% (minimum 99%, Baseline (adaptation disabled)); liver: 81.2500% (minimum 99%, Baseline (adaptation disabled)); lung: 65.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 81.2500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.8571% (minimum 99%, Baseline (adaptation disabled)); pancreas: 50.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.9048% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.4706% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.4706% (minimum 97%, Baseline (adaptation disabled)); retina: 61.9048% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.9048% (minimum 97%, Baseline (adaptation disabled)); skin: 92.8571% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.2500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.2500% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.2500% (minimum 99%, Baseline (adaptation disabled)); stomach: 81.2500% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.5217% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.8571% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.3,0.8,1,"pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000204764,RANBP17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.384783,-0.350952,-0.49
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.6667% (minimum 95%, Missing); adrenal gland: 65.0000% (minimum 99%, Missing); amygdala: 92.8571% (minimum 99%, Missing); basal ganglia: 92.8571% (minimum 99%, Missing); bone marrow: 92.8571% (minimum 99%, Missing); cerebellum: 81.2500% (minimum 99%, Missing); cerebral cortex: 76.4706% (minimum 99%, Missing); choroid plexus: 76.4706% (minimum 99%, Missing); colon: 86.6667% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); heart muscle: 86.6667% (minimum 99%, Missing); hippocampal formation: 92.8571% (minimum 99%, Missing); hypothalamus: 86.6667% (minimum 99%, Missing); kidney: 76.4706% (minimum 99%, Missing); liver: 81.2500% (minimum 99%, Missing); lung: 65.0000% (minimum 99%, Missing); lymph node: 81.2500% (minimum 97%, Missing); midbrain: 92.8571% (minimum 99%, Missing); pancreas: 50.0000% (minimum 99%, Missing); parathyroid gland: 61.9048% (minimum 97%, Missing); pituitary gland: 76.4706% (minimum 99%, Missing); rectum: 76.4706% (minimum 97%, Missing); retina: 61.9048% (minimum 99%, Missing); salivary gland: 61.9048% (minimum 97%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 81.2500% (minimum 99%, Missing); smooth muscle: 81.2500% (minimum 99%, Missing); spinal cord: 81.2500% (minimum 99%, Missing); stomach: 81.2500% (minimum 97%, Missing); thymus: 86.6667% (minimum 95%, Missing); thyroid gland: 56.5217% (minimum 95%, Missing); urinary bladder: 92.8571% (minimum 97%, Missing)",0,80,unavailable,1.3,0.8,1,"pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000204764,RANBP17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.384783,-0.350952,-0.49
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204849,SPATA31A1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204849,SPATA31A1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204849,SPATA31A1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,0.1,0.2,108.8,"skin: 108.8 nTPM (manageable, limit 5)",,71,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000204897,KRT25,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 95%, Baseline (adaptation disabled)); cerebellum: 96.2963% (minimum 99%, Baseline (adaptation disabled)); colon: 92.8571% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.2963% (minimum 99%, Baseline (adaptation disabled)); skin: 2.3339% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 96.2963% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,0.1,0.2,108.8,"skin: 108.8 nTPM (manageable, limit 5)",,71,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000204897,KRT25,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.926661,-0.0414286,-0.027037
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 60%, Enhanced); pituitary gland: 96.2963% (minimum 99%, Missing); skin: 2.3339% (minimum 95%, Missing)",0,4,partial,0.1,0.2,108.8,"skin: 108.8 nTPM (manageable, limit 5)",,71,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,ENSG00000204897,KRT25,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.926661,0.03,-0.027037
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204918,PRR20B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204918,PRR20B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204918,PRR20B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204919,PRR20A,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204919,PRR20A,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204919,PRR20A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,5,partial,2.8,0.5,0.3,,kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000204930,FAM221B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 98.9583% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.9583% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.9583% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 77.2358% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9583% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.9583% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9583% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9583% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.9388% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9583% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9583% (minimum 99%, Baseline (adaptation disabled)); liver: 98.9583% (minimum 99%, Baseline (adaptation disabled)); lung: 98.9583% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.0000% (minimum 97%, Baseline (adaptation disabled)); pancreas: 98.9583% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 95.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.9388% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.9583% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.9381% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.9388% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 96.9388% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,2.8,0.5,0.3,"bone marrow: 2.8 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000204930,FAM221B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0193878,-0.02,-0.217642
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.9583% (minimum 99%, Missing); basal ganglia: 98.9583% (minimum 99%, Missing); bone marrow: 77.2358% (minimum 95%, Enhanced); choroid plexus: 98.9583% (minimum 99%, Missing); hippocampal formation: 98.9583% (minimum 99%, Missing); hypothalamus: 98.9583% (minimum 99%, Missing); lung: 98.9583% (minimum 99%, Missing); lymph node: 95.0000% (minimum 97%, Missing); retina: 95.0000% (minimum 99%, Missing); spinal cord: 97.9381% (minimum 99%, Missing); stomach: 96.9388% (minimum 97%, Missing)",0,5,partial,2.8,0.5,0.3,,kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000204930,FAM221B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0193878,-0.02,-0.177642
True,compatible,,True,True,False,,0,2,partial,0.8,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000204941,PSG5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,,True,True,True,,0,2,partial,0.8,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000204941,PSG5,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.045417,0.0272452,0.00268739
True,compatible,,True,True,True,,0,2,partial,0.8,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000204941,PSG5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.00724518
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.6,2.3,2.4,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204947,ZNF425,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 82.0513% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.7273% (minimum 99%, Baseline (adaptation disabled)); amygdala: 56.1404% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.2373% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.2105% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 48.4848% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.4848% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.0851% (minimum 99%, Baseline (adaptation disabled)); colon: 61.5385% (minimum 97%, Baseline (adaptation disabled)); duodenum: 78.0488% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.3774% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.1818% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.1818% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.2593% (minimum 99%, Baseline (adaptation disabled)); liver: 76.1905% (minimum 99%, Baseline (adaptation disabled)); lung: 76.1905% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.5385% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.5652% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.1818% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.5652% (minimum 99%, Baseline (adaptation disabled)); rectum: 82.0513% (minimum 97%, Baseline (adaptation disabled)); retina: 71.1111% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 65.3061% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 47.0588% (minimum 99%, Baseline (adaptation disabled)); skin: 57.1429% (minimum 95%, Baseline (adaptation disabled)); small intestine: 78.0488% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 65.3061% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.7451% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.0488% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.0851% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.0851% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.7451% (minimum 95%, Baseline (adaptation disabled)); tongue: 64.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.6,2.3,2.4,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204947,ZNF425,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.378571,-0.388182,-0.519412
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 82.0513% (minimum 95%, Missing); adrenal gland: 72.7273% (minimum 99%, Missing); amygdala: 56.1404% (minimum 99%, Missing); basal ganglia: 54.2373% (minimum 99%, Missing); bone marrow: 84.2105% (minimum 99%, Missing); cerebellum: 48.4848% (minimum 99%, Missing); cerebral cortex: 48.4848% (minimum 99%, Missing); choroid plexus: 68.0851% (minimum 99%, Missing); colon: 61.5385% (minimum 97%, Missing); duodenum: 78.0488% (minimum 99%, Missing); esophagus: 60.3774% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 58.1818% (minimum 99%, Missing); hypothalamus: 58.1818% (minimum 99%, Missing); kidney: 59.2593% (minimum 99%, Missing); liver: 76.1905% (minimum 99%, Missing); lung: 76.1905% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 61.5385% (minimum 99%, Missing); pancreas: 69.5652% (minimum 99%, Missing); parathyroid gland: 58.1818% (minimum 97%, Missing); pituitary gland: 69.5652% (minimum 99%, Missing); rectum: 82.0513% (minimum 97%, Missing); retina: 71.1111% (minimum 99%, Missing); salivary gland: 65.3061% (minimum 97%, Missing); skeletal muscle: 47.0588% (minimum 99%, Missing); skin: 57.1429% (minimum 95%, Missing); small intestine: 78.0488% (minimum 99%, Missing); smooth muscle: 65.3061% (minimum 99%, Missing); spinal cord: 62.7451% (minimum 99%, Missing); spleen: 78.0488% (minimum 95%, Missing); stomach: 68.0851% (minimum 97%, Missing); thymus: 68.0851% (minimum 95%, Missing); thyroid gland: 62.7451% (minimum 95%, Missing); tongue: 64.0000% (minimum 97%, Missing); urinary bladder: 64.0000% (minimum 97%, Missing)",0,80,unavailable,3.6,2.3,2.4,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); esophagus: 2.1 nTPM (protected, limit 2); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204947,ZNF425,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.378571,-0.388182,-0.519412
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204952,FBXO47,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204952,FBXO47,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204952,FBXO47,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.8,0.5,0.3,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204956,PCDHGA1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.9231% (minimum 99%, Baseline (adaptation disabled)); amygdala: 58.8235% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 40.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.9091% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.4783% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 35.7143% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.9091% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 45.4545% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.5556% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 76.9231% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.9091% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.9091% (minimum 97%, Baseline (adaptation disabled)); retina: 47.6190% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 76.9231% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.9091% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 71.4286% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.9091% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.9091% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.9091% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 83.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 76.9231% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.4286% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.8,0.5,0.3,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204956,PCDHGA1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.180769,-0.303333,-0.632857
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.9231% (minimum 95%, Missing); adrenal gland: 76.9231% (minimum 99%, Missing); amygdala: 58.8235% (minimum 99%, Missing); basal ganglia: 40.0000% (minimum 99%, Missing); bone marrow: 90.9091% (minimum 99%, Missing); cerebellum: 43.4783% (minimum 99%, Missing); cerebral cortex: 35.7143% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 90.9091% (minimum 99%, Missing); esophagus: 83.3333% (minimum 97%, Missing); heart muscle: 45.4545% (minimum 99%, Missing); hippocampal formation: 55.5556% (minimum 99%, Missing); hypothalamus: 62.5000% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); lung: 76.9231% (minimum 99%, Missing); lymph node: 90.9091% (minimum 97%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 66.6667% (minimum 97%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); rectum: 90.9091% (minimum 97%, Missing); retina: 47.6190% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 62.5000% (minimum 99%, Missing); skin: 76.9231% (minimum 95%, Missing); small intestine: 90.9091% (minimum 99%, Missing); smooth muscle: 71.4286% (minimum 99%, Missing); spinal cord: 71.4286% (minimum 99%, Missing); spleen: 90.9091% (minimum 95%, Missing); stomach: 90.9091% (minimum 97%, Missing); thymus: 90.9091% (minimum 95%, Missing); thyroid gland: 83.3333% (minimum 95%, Missing); tongue: 76.9231% (minimum 97%, Missing); urinary bladder: 71.4286% (minimum 97%, Missing)",0,80,unavailable,1.8,0.5,0.3,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000204956,PCDHGA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.180769,-0.303333,-0.632857
True,compatible,,True,True,False,,0,80,unavailable,0.8,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000204961,PCDHA9,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.8947% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.6667% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 61.1111% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 78.5714% (minimum 99%, Baseline (adaptation disabled)); skin: 91.6667% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 73.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000204961,PCDHA9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.0333333,0.03,-0.411053
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 91.6667% (minimum 95%, Missing); adrenal gland: 91.6667% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 91.6667% (minimum 99%, Missing); bone marrow: 91.6667% (minimum 99%, Missing); cerebellum: 57.8947% (minimum 99%, Missing); cerebral cortex: 73.3333% (minimum 99%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 91.6667% (minimum 99%, Missing); midbrain: 91.6667% (minimum 99%, Missing); pancreas: 61.1111% (minimum 99%, Missing); pituitary gland: 91.6667% (minimum 99%, Missing); retina: 78.5714% (minimum 99%, Missing); skin: 91.6667% (minimum 95%, Missing); spinal cord: 73.3333% (minimum 99%, Missing)",0,80,unavailable,0.8,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000204961,PCDHA9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.0333333,0.03,-0.411053
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,1.8,0,0,"cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000204962,PCDHA8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 50.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 14.2857% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 37.5000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 50.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 50.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 60.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 37.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.8,0,0,"cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000204962,PCDHA8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.847143
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adrenal gland: 75.0000% (minimum 99%, Missing); amygdala: 50.0000% (minimum 99%, Missing); basal ganglia: 60.0000% (minimum 99%, Missing); cerebellum: 14.2857% (minimum 99%, Missing); cerebral cortex: 37.5000% (minimum 99%, Missing); hippocampal formation: 50.0000% (minimum 99%, Missing); hypothalamus: 50.0000% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); midbrain: 60.0000% (minimum 99%, Missing); pancreas: 75.0000% (minimum 99%, Missing); pituitary gland: 50.0000% (minimum 99%, Missing); retina: 37.5000% (minimum 99%, Missing); spinal cord: 50.0000% (minimum 99%, Missing)",0,80,unavailable,1.8,0,0,"cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000204962,PCDHA8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.847143
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,1.7,0.2,0.2,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; spleen,ENSG00000204963,PCDHA7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.7273% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 32.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 80.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.5385% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.7273% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 61.5385% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.7273% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 88.8889% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 88.8889% (minimum 97%, Baseline (adaptation disabled)); small intestine: 88.8889% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 40.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.8889% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.8889% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 88.8889% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 88.8889% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.7,0.2,0.2,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; spleen,ENSG00000204963,PCDHA7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.15,-0.17,-0.67
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 80.0000% (minimum 95%, Missing); adrenal gland: 88.8889% (minimum 99%, Missing); amygdala: 72.7273% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); cerebellum: 32.0000% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); duodenum: 88.8889% (minimum 99%, Missing); hippocampal formation: 61.5385% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 72.7273% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); midbrain: 61.5385% (minimum 99%, Missing); pancreas: 72.7273% (minimum 99%, Missing); parathyroid gland: 88.8889% (minimum 97%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 88.8889% (minimum 97%, Missing); small intestine: 88.8889% (minimum 99%, Missing); smooth muscle: 88.8889% (minimum 99%, Missing); spinal cord: 40.0000% (minimum 99%, Missing); spleen: 88.8889% (minimum 95%, Missing); stomach: 88.8889% (minimum 97%, Missing); thyroid gland: 88.8889% (minimum 95%, Missing); urinary bladder: 88.8889% (minimum 97%, Missing)",0,80,unavailable,1.7,0.2,0.2,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; spleen,ENSG00000204963,PCDHA7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.15,-0.17,-0.67
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,0,routine_complete,2.8,0.1,0.1,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),55,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000204965,PCDHA5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 27.2727% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 37.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 9.6774% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 12.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 30.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 30.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 37.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 37.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 42.8571% (minimum 99%, Baseline (adaptation disabled))",0,0,routine_complete,2.8,0.1,0.1,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),55,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000204965,PCDHA5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.2,-0.22,-0.893226
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 75.0000% (minimum 90%, Approved); adrenal gland: 75.0000% (minimum 98%, Approved); amygdala: 27.2727% (minimum 99%, Missing); basal ganglia: 37.5000% (minimum 99%, Missing); cerebellum: 9.6774% (minimum 99%, Missing); cerebral cortex: 12.5000% (minimum 99%, Missing); colon: 75.0000% (minimum 95%, Approved); hippocampal formation: 30.0000% (minimum 99%, Missing); hypothalamus: 30.0000% (minimum 99%, Missing); kidney: 75.0000% (minimum 98%, Approved); lung: 75.0000% (minimum 98%, Approved); midbrain: 37.5000% (minimum 99%, Missing); pancreas: 60.0000% (minimum 98%, Approved); pituitary gland: 37.5000% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing); spinal cord: 42.8571% (minimum 99%, Missing)",0,0,routine_complete,2.8,0.1,0.1,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),55,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000204965,PCDHA5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.15,-0.2,-0.893226
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,2,0.3,0.4,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000204967,PCDHA4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4286% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 38.4615% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 33.3333% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 38.4615% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 22.7273% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 20.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 71.4286% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.4286% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.3333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 38.4615% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 35.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.5556% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 55.5556% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 29.4118% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.5000% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.4286% (minimum 97%, Baseline (adaptation disabled)); retina: 38.4615% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.4286% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.4286% (minimum 99%, Baseline (adaptation disabled)); skin: 55.5556% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.4286% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 71.4286% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.4286% (minimum 97%, Baseline (adaptation disabled)); thymus: 83.3333% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.4286% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.3333% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 71.4286% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,2,0.3,0.4,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000204967,PCDHA4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.394444,-0.345,-0.79
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 71.4286% (minimum 90%, Approved); adrenal gland: 83.3333% (minimum 98%, Approved); amygdala: 38.4615% (minimum 99%, Missing); basal ganglia: 33.3333% (minimum 99%, Missing); bone marrow: 38.4615% (minimum 98%, Approved); cerebellum: 22.7273% (minimum 99%, Missing); cerebral cortex: 20.0000% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 71.4286% (minimum 97%, Missing); duodenum: 71.4286% (minimum 99%, Missing); esophagus: 83.3333% (minimum 95%, Approved); heart muscle: 83.3333% (minimum 98%, Approved); hippocampal formation: 38.4615% (minimum 99%, Missing); hypothalamus: 35.7143% (minimum 99%, Missing); kidney: 55.5556% (minimum 99%, Missing); liver: 83.3333% (minimum 98%, Approved); lung: 55.5556% (minimum 98%, Approved); lymph node: 62.5000% (minimum 95%, Approved); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 29.4118% (minimum 99%, Missing); parathyroid gland: 83.3333% (minimum 95%, Approved); pituitary gland: 62.5000% (minimum 99%, Missing); rectum: 71.4286% (minimum 97%, Missing); retina: 38.4615% (minimum 99%, Missing); salivary gland: 71.4286% (minimum 95%, Approved); skeletal muscle: 71.4286% (minimum 98%, Approved); skin: 55.5556% (minimum 90%, Approved); small intestine: 71.4286% (minimum 99%, Missing); smooth muscle: 62.5000% (minimum 98%, Approved); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 71.4286% (minimum 90%, Approved); stomach: 71.4286% (minimum 97%, Missing); thymus: 83.3333% (minimum 95%, Missing); thyroid gland: 71.4286% (minimum 90%, Approved); tongue: 83.3333% (minimum 97%, Missing); urinary bladder: 71.4286% (minimum 97%, Missing)",0,3,partial,2,0.3,0.4,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000204967,PCDHA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.344444,-0.325,-0.79
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,2.4,0.2,0.1,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000204969,PCDHA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 88.8889% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); amygdala: 53.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 57.1429% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 25.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 80.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 53.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 57.1429% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.7273% (minimum 99%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 72.7273% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 32.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 61.5385% (minimum 99%, Baseline (adaptation disabled)); small intestine: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.5385% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.8889% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.8889% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 88.8889% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,2.4,0.2,0.1,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000204969,PCDHA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0611111,-0.17,-0.74
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 88.8889% (minimum 95%, Missing); adrenal gland: 88.8889% (minimum 99%, Missing); amygdala: 53.3333% (minimum 99%, Missing); basal ganglia: 57.1429% (minimum 99%, Missing); cerebellum: 25.0000% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); colon: 80.0000% (minimum 97%, Missing); heart muscle: 88.8889% (minimum 99%, Missing); hippocampal formation: 53.3333% (minimum 99%, Missing); hypothalamus: 57.1429% (minimum 99%, Missing); kidney: 72.7273% (minimum 99%, Missing); lung: 80.0000% (minimum 99%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 72.7273% (minimum 99%, Missing); pituitary gland: 32.0000% (minimum 99%, Missing); retina: 61.5385% (minimum 99%, Missing); small intestine: 88.8889% (minimum 99%, Missing); spinal cord: 61.5385% (minimum 99%, Missing); spleen: 88.8889% (minimum 95%, Missing); stomach: 88.8889% (minimum 97%, Missing); thyroid gland: 88.8889% (minimum 95%, Missing)",0,80,unavailable,2.4,0.2,0.1,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000204969,PCDHA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0611111,-0.17,-0.74
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,2.8,0.1,0,"spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),53,not_established,not_triggered,,,ENSG00000204970,PCDHA1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 40.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 32.2581% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 30.3030% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 31.2500% (minimum 99%, Baseline (adaptation disabled)); colon: 90.9091% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.9091% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 35.7143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 35.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.9091% (minimum 99%, Baseline (adaptation disabled)); midbrain: 41.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 90.9091% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 76.9231% (minimum 99%, Baseline (adaptation disabled)); small intestine: 90.9091% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 26.3158% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,2.8,0.1,0,"spinal cord: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),53,not_established,not_triggered,,,ENSG00000204970,PCDHA1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,0.05,-0.0609091,-0.726842
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 83.3333% (minimum 95%, Enhanced); amygdala: 40.0000% (minimum 99%, Missing); basal ganglia: 32.2581% (minimum 99%, Missing); cerebellum: 30.3030% (minimum 95%, Enhanced); cerebral cortex: 31.2500% (minimum 99%, Missing); duodenum: 90.9091% (minimum 95%, Enhanced); hippocampal formation: 35.7143% (minimum 99%, Missing); hypothalamus: 35.7143% (minimum 99%, Missing); kidney: 90.9091% (minimum 95%, Enhanced); midbrain: 41.6667% (minimum 99%, Missing); pancreas: 90.9091% (minimum 95%, Enhanced); pituitary gland: 50.0000% (minimum 99%, Missing); retina: 76.9231% (minimum 99%, Missing); small intestine: 90.9091% (minimum 95%, Enhanced); spinal cord: 26.3158% (minimum 99%, Missing)",0,1,partial,2.8,0.1,0,"spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),53,not_established,not_triggered,,,ENSG00000204970,PCDHA1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,0.05,0.03,-0.726842
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204979,MS4A13,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204979,MS4A13,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000204979,MS4A13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.1,4.9,3.3,"salivary gland: 4.9 nTPM (protected, limit 2); kidney: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205078,SYCE1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.7638% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.2149% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.4118% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.9355% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 90.4762% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.9355% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 91.9355% (minimum 99%, Baseline (adaptation disabled)); colon: 93.0612% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.0213% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.8272% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.6058% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.1186% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.0309% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.0309% (minimum 99%, Baseline (adaptation disabled)); liver: 94.2149% (minimum 99%, Baseline (adaptation disabled)); lung: 94.2149% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.2025% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.9355% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.3077% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.5663% (minimum 99%, Baseline (adaptation disabled)); retina: 89.4118% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.3105% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.6102% (minimum 99%, Baseline (adaptation disabled)); skin: 89.0625% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.5663% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.2759% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.2000% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.9355% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.3975% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 87.3563% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 90.8367% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.1,4.9,3.3,"salivary gland: 4.9 nTPM (protected, limit 2); kidney: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205078,SYCE1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0764368,-0.146895,-0.109691
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.7638% (minimum 95%, Missing); adrenal gland: 94.2149% (minimum 99%, Missing); amygdala: 89.4118% (minimum 99%, Missing); basal ganglia: 91.9355% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 90.4762% (minimum 99%, Missing); cerebral cortex: 91.9355% (minimum 99%, Missing); choroid plexus: 91.9355% (minimum 99%, Missing); colon: 93.0612% (minimum 97%, Missing); duodenum: 97.0213% (minimum 99%, Missing); esophagus: 93.8272% (minimum 97%, Missing); heart muscle: 94.6058% (minimum 99%, Missing); hippocampal formation: 90.1186% (minimum 99%, Missing); hypothalamus: 88.0309% (minimum 99%, Missing); kidney: 88.0309% (minimum 99%, Missing); liver: 94.2149% (minimum 99%, Missing); lung: 94.2149% (minimum 99%, Missing); lymph node: 96.2025% (minimum 97%, Missing); midbrain: 91.9355% (minimum 99%, Missing); pancreas: 92.3077% (minimum 99%, Missing); pituitary gland: 91.5663% (minimum 99%, Missing); retina: 89.4118% (minimum 99%, Missing); salivary gland: 82.3105% (minimum 97%, Missing); skeletal muscle: 96.6102% (minimum 99%, Missing); skin: 89.0625% (minimum 95%, Missing); small intestine: 91.5663% (minimum 99%, Missing); smooth muscle: 98.2759% (minimum 99%, Missing); spinal cord: 91.2000% (minimum 99%, Missing); spleen: 91.9355% (minimum 95%, Missing); stomach: 95.3975% (minimum 97%, Missing); thyroid gland: 87.3563% (minimum 95%, Missing); urinary bladder: 90.8367% (minimum 97%, Missing)",0,80,unavailable,3.1,4.9,3.3,"salivary gland: 4.9 nTPM (protected, limit 2); kidney: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205078,SYCE1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,-0.0764368,-0.146895,-0.109691
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,4.3,2.3,2.6,"pituitary gland: 4.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205085,GARIN1A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 94.6524% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.6702% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.9350% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.1489% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.2527% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.7098% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.1579% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7901% (minimum 99%, Baseline (adaptation disabled)); colon: 95.9350% (minimum 97%, Baseline (adaptation disabled)); esophagus: 96.7213% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 91.4729% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.9350% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.9350% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.9481% (minimum 99%, Baseline (adaptation disabled)); liver: 95.6757% (minimum 99%, Baseline (adaptation disabled)); lung: 96.7213% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.6757% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.4178% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 89.1688% (minimum 99%, Baseline (adaptation disabled)); retina: 95.1613% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.8992% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.6757% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.4578% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.4178% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.1579% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.9350% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 94.6524% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.1957% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,4.3,2.3,2.6,"pituitary gland: 4.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205085,GARIN1A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0184211,-0.031008,-0.0983123
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.6702% (minimum 95%, Enhanced); amygdala: 95.9350% (minimum 99%, Missing); basal ganglia: 94.1489% (minimum 99%, Missing); cerebellum: 91.7098% (minimum 95%, Enhanced); cerebral cortex: 93.1579% (minimum 95%, Enhanced); choroid plexus: 97.7901% (minimum 99%, Missing); heart muscle: 91.4729% (minimum 95%, Enhanced); hippocampal formation: 95.9350% (minimum 99%, Missing); hypothalamus: 95.9350% (minimum 99%, Missing); kidney: 91.9481% (minimum 95%, Enhanced); midbrain: 95.6757% (minimum 99%, Missing); pituitary gland: 89.1688% (minimum 99%, Missing); retina: 95.1613% (minimum 99%, Missing); spinal cord: 95.4178% (minimum 99%, Missing)",0,1,partial,4.3,2.3,2.6,"pituitary gland: 4.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205085,GARIN1A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0471831,0.03,-0.0983123
True,compatible,,True,True,False,,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205108,SPATA31F1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205108,SPATA31F1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0458678,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205108,SPATA31F1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.7,0.1,0.1,,,0,not_established,not_triggered,,,ENSG00000205111,CDKL4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.2381% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.9091% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.9091% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 74.0741% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.2381% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.9565% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.2381% (minimum 99%, Baseline (adaptation disabled)); lung: 95.2381% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.2381% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.2381% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 95.2381% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.2381% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.1,0.1,,,0,not_established,not_triggered,,,ENSG00000205111,CDKL4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00238095,-0.017619,-0.249259
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 95.2381% (minimum 99%, Missing); basal ganglia: 90.9091% (minimum 99%, Missing); cerebral cortex: 90.9091% (minimum 99%, Missing); choroid plexus: 74.0741% (minimum 99%, Missing); heart muscle: 95.2381% (minimum 99%, Missing); hippocampal formation: 95.2381% (minimum 99%, Missing); hypothalamus: 86.9565% (minimum 99%, Missing); kidney: 95.2381% (minimum 99%, Missing); lung: 95.2381% (minimum 99%, Missing); midbrain: 95.2381% (minimum 99%, Missing); parathyroid gland: 95.2381% (minimum 97%, Missing); pituitary gland: 80.0000% (minimum 99%, Missing); retina: 95.2381% (minimum 99%, Missing); skeletal muscle: 95.2381% (minimum 99%, Missing); spinal cord: 95.2381% (minimum 99%, Missing)",0,80,unavailable,0.7,0.1,0.1,,,0,not_established,not_triggered,,,ENSG00000205111,CDKL4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00238095,-0.017619,-0.249259
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,30.8,0.5,4.1,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205129,CFAP96,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 97.4790% (minimum 99%, Baseline (adaptation disabled)); amygdala: 85.2941% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.6049% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.4790% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.8000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.8000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 27.3585% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 92.8000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.9116% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.6901% (minimum 99%, Baseline (adaptation disabled)); liver: 97.4790% (minimum 99%, Baseline (adaptation disabled)); lung: 87.2180% (minimum 99%, Baseline (adaptation disabled)); midbrain: 89.2308% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.3089% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.8678% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 80.5556% (minimum 99%, Baseline (adaptation disabled)); retina: 46.9636% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.8678% (minimum 97%, Baseline (adaptation disabled)); skin: 92.8000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 98.3051% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.4790% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.8788% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 73.8854% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,30.8,0.5,4.1,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205129,CFAP96,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.211146,-0.0113223,-0.716415
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 85.2941% (minimum 99%, Missing); basal ganglia: 71.6049% (minimum 99%, Missing); cerebellum: 92.8000% (minimum 95%, Enhanced); cerebral cortex: 92.8000% (minimum 95%, Enhanced); choroid plexus: 27.3585% (minimum 99%, Missing); heart muscle: 92.8000% (minimum 95%, Enhanced); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 78.9116% (minimum 99%, Missing); kidney: 81.6901% (minimum 95%, Enhanced); lung: 87.2180% (minimum 95%, Enhanced); midbrain: 89.2308% (minimum 99%, Missing); pancreas: 94.3089% (minimum 95%, Enhanced); pituitary gland: 80.5556% (minimum 99%, Missing); retina: 46.9636% (minimum 99%, Missing); spinal cord: 87.8788% (minimum 99%, Missing)",0,4,partial,30.8,0.5,4.1,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205129,CFAP96,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,0.0330508,0.021453,-0.716415
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,30.4,20.3,22.7,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 2); colon: 20 nTPM (protected, limit 2); parathyroid gland: 19.9 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 2); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 2); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); adipose tissue: 12.3 nTPM (manageable, limit 5); amygdala: 12.3 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); salivary gland: 10.8 nTPM (protected, limit 2); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 2); choroid plexus: 8.1 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 2); lymph node: 5.2 nTPM (protected, limit 2); skeletal muscle: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205133,TRIQK,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.5769% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 47.1322% (minimum 99%, Baseline (adaptation disabled)); amygdala: 60.5769% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.0831% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 56.9277% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.6243% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 51.7808% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 48.5861% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.1650% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.5493% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 49.3473% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.7647% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.9672% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.2660% (minimum 99%, Baseline (adaptation disabled)); liver: 38.3367% (minimum 99%, Baseline (adaptation disabled)); lung: 53.3898% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.4232% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.3762% (minimum 99%, Baseline (adaptation disabled)); pancreas: 52.0661% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 48.7113% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 64.5051% (minimum 99%, Baseline (adaptation disabled)); rectum: 48.2143% (minimum 97%, Baseline (adaptation disabled)); retina: 61.1650% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.6364% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.1509% (minimum 99%, Baseline (adaptation disabled)); skin: 77.4590% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.5635% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.2107% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 54.7826% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.6215% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.6462% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.6923% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 45.4327% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.7778% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.9172% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,30.4,20.3,22.7,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 2); colon: 20 nTPM (protected, limit 2); parathyroid gland: 19.9 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 2); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 2); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); adipose tissue: 12.3 nTPM (manageable, limit 5); amygdala: 12.3 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); salivary gland: 10.8 nTPM (protected, limit 2); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 2); choroid plexus: 8.1 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 2); lymph node: 5.2 nTPM (protected, limit 2); skeletal muscle: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205133,TRIQK,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.495673,-0.487857,-0.606633
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.5769% (minimum 95%, Missing); adrenal gland: 47.1322% (minimum 99%, Missing); amygdala: 60.5769% (minimum 99%, Missing); basal ganglia: 56.0831% (minimum 99%, Missing); bone marrow: 56.9277% (minimum 99%, Missing); cerebellum: 54.6243% (minimum 99%, Missing); cerebral cortex: 51.7808% (minimum 99%, Missing); choroid plexus: 70.0000% (minimum 99%, Missing); colon: 48.5861% (minimum 97%, Missing); duodenum: 61.1650% (minimum 99%, Missing); esophagus: 66.5493% (minimum 97%, Missing); heart muscle: 49.3473% (minimum 99%, Missing); hippocampal formation: 61.7647% (minimum 99%, Missing); hypothalamus: 61.9672% (minimum 99%, Missing); kidney: 50.2660% (minimum 99%, Missing); liver: 38.3367% (minimum 99%, Missing); lung: 53.3898% (minimum 99%, Missing); lymph node: 78.4232% (minimum 97%, Missing); midbrain: 62.3762% (minimum 99%, Missing); pancreas: 52.0661% (minimum 99%, Missing); parathyroid gland: 48.7113% (minimum 97%, Missing); pituitary gland: 64.5051% (minimum 99%, Missing); rectum: 48.2143% (minimum 97%, Missing); retina: 61.1650% (minimum 99%, Missing); salivary gland: 63.6364% (minimum 97%, Missing); skeletal muscle: 89.1509% (minimum 99%, Missing); skin: 77.4590% (minimum 95%, Missing); small intestine: 61.5635% (minimum 99%, Missing); smooth muscle: 63.2107% (minimum 99%, Missing); spinal cord: 54.7826% (minimum 99%, Missing); spleen: 59.6215% (minimum 95%, Missing); stomach: 52.6462% (minimum 97%, Missing); thymus: 72.6923% (minimum 95%, Missing); thyroid gland: 45.4327% (minimum 95%, Missing); tongue: 77.7778% (minimum 97%, Missing); urinary bladder: 55.9172% (minimum 97%, Missing)",0,80,unavailable,30.4,20.3,22.7,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 2); colon: 20 nTPM (protected, limit 2); parathyroid gland: 19.9 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 2); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 2); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); adipose tissue: 12.3 nTPM (manageable, limit 5); amygdala: 12.3 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); salivary gland: 10.8 nTPM (protected, limit 2); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 2); choroid plexus: 8.1 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 2); lymph node: 5.2 nTPM (protected, limit 2); skeletal muscle: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205133,TRIQK,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.495673,-0.487857,-0.606633
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,2.9,4.6,"esophagus: 2.9 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000205177,C11orf91,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.9065% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 97.8947% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.8763% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.8750% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 90.2913% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9362% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.8750% (minimum 99%, Baseline (adaptation disabled)); colon: 95.8763% (minimum 97%, Baseline (adaptation disabled)); esophagus: 76.2295% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.0792% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.8947% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.8763% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.7358% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8947% (minimum 99%, Baseline (adaptation disabled)); lung: 89.4231% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.8763% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.1111% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.9362% (minimum 99%, Baseline (adaptation disabled)); retina: 98.9362% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.8980% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.8980% (minimum 99%, Baseline (adaptation disabled)); skin: 90.2913% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.8750% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.8947% (minimum 99%, Baseline (adaptation disabled)); stomach: 82.3009% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 86.9159% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.5,2.9,4.6,"esophagus: 2.9 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000205177,C11orf91,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.280935,-0.207705,-0.128889
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.9065% (minimum 95%, Missing); adrenal gland: 97.8947% (minimum 99%, Missing); amygdala: 95.8763% (minimum 99%, Missing); basal ganglia: 96.8750% (minimum 99%, Missing); bone marrow: 90.2913% (minimum 99%, Missing); cerebellum: 98.9362% (minimum 99%, Missing); cerebral cortex: 96.8750% (minimum 99%, Missing); colon: 95.8763% (minimum 97%, Missing); esophagus: 76.2295% (minimum 97%, Missing); heart muscle: 92.0792% (minimum 99%, Missing); hippocampal formation: 97.8947% (minimum 99%, Missing); hypothalamus: 95.8763% (minimum 99%, Missing); kidney: 87.7358% (minimum 99%, Missing); liver: 97.8947% (minimum 99%, Missing); lung: 89.4231% (minimum 99%, Missing); midbrain: 95.8763% (minimum 99%, Missing); pancreas: 86.1111% (minimum 99%, Missing); pituitary gland: 98.9362% (minimum 99%, Missing); retina: 98.9362% (minimum 99%, Missing); salivary gland: 94.8980% (minimum 97%, Missing); skeletal muscle: 94.8980% (minimum 99%, Missing); skin: 90.2913% (minimum 95%, Missing); small intestine: 96.8750% (minimum 99%, Missing); smooth muscle: 93.0000% (minimum 99%, Missing); spinal cord: 97.8947% (minimum 99%, Missing); stomach: 82.3009% (minimum 97%, Missing); urinary bladder: 86.9159% (minimum 97%, Missing)",0,80,unavailable,1.5,2.9,4.6,"esophagus: 2.9 nTPM (protected, limit 2); pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000205177,C11orf91,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.280935,-0.207705,-0.128889
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,14.3,5.9,9.9,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 2); tongue: 5.8 nTPM (protected, limit 2); rectum: 4 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000205208,C4orf46,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.7838% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 84.3537% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.5714% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 89.8551% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 46.4419% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.3537% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.9315% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.8750% (minimum 99%, Baseline (adaptation disabled)); colon: 79.4872% (minimum 97%, Baseline (adaptation disabled)); duodenum: 81.0458% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.5789% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.9874% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.9433% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 89.8551% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.7133% (minimum 99%, Baseline (adaptation disabled)); liver: 89.2086% (minimum 99%, Baseline (adaptation disabled)); lung: 83.2215% (minimum 99%, Baseline (adaptation disabled)); lymph node: 67.7596% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.9433% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.3537% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.9433% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.8519% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.6098% (minimum 97%, Baseline (adaptation disabled)); retina: 57.4074% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.9433% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.1111% (minimum 99%, Baseline (adaptation disabled)); skin: 81.5789% (minimum 95%, Baseline (adaptation disabled)); small intestine: 82.1192% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.0736% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.1192% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 83.2215% (minimum 97%, Baseline (adaptation disabled)); thymus: 55.6054% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.1515% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.1319% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.2215% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,14.3,5.9,9.9,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 2); tongue: 5.8 nTPM (protected, limit 2); rectum: 4 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000205208,C4orf46,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.393946,-0.292404,-0.525581
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 83.7838% (minimum 95%, Uncertain); adrenal gland: 84.3537% (minimum 99%, Uncertain); amygdala: 88.5714% (minimum 99%, Missing); basal ganglia: 89.8551% (minimum 99%, Missing); bone marrow: 46.4419% (minimum 99%, Uncertain); cerebellum: 84.3537% (minimum 99%, Uncertain); cerebral cortex: 84.9315% (minimum 99%, Missing); choroid plexus: 96.8750% (minimum 99%, Missing); colon: 79.4872% (minimum 97%, Missing); duodenum: 81.0458% (minimum 99%, Uncertain); esophagus: 81.5789% (minimum 97%, Uncertain); heart muscle: 77.9874% (minimum 99%, Missing); hippocampal formation: 87.9433% (minimum 99%, Missing); hypothalamus: 89.8551% (minimum 99%, Missing); kidney: 86.7133% (minimum 99%, Missing); liver: 89.2086% (minimum 99%, Uncertain); lung: 83.2215% (minimum 99%, Uncertain); lymph node: 67.7596% (minimum 97%, Missing); midbrain: 87.9433% (minimum 99%, Missing); pancreas: 84.3537% (minimum 99%, Uncertain); parathyroid gland: 87.9433% (minimum 97%, Uncertain); pituitary gland: 91.8519% (minimum 99%, Missing); rectum: 75.6098% (minimum 97%, Uncertain); retina: 57.4074% (minimum 99%, Missing); salivary gland: 87.9433% (minimum 97%, Uncertain); skeletal muscle: 86.1111% (minimum 99%, Missing); skin: 81.5789% (minimum 95%, Missing); small intestine: 82.1192% (minimum 99%, Missing); smooth muscle: 76.0736% (minimum 99%, Uncertain); spinal cord: 82.1192% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 83.2215% (minimum 97%, Uncertain); thymus: 55.6054% (minimum 95%, Missing); thyroid gland: 75.1515% (minimum 95%, Uncertain); tongue: 68.1319% (minimum 97%, Missing); urinary bladder: 83.2215% (minimum 97%, Uncertain)",0,1,partial,14.3,5.9,9.9,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 2); tongue: 5.8 nTPM (protected, limit 2); rectum: 4 nTPM (protected, limit 2); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 2); duodenum: 2.9 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); urinary bladder: 2.5 nTPM (protected, limit 2); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000205208,C4orf46,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.393946,-0.292404,-0.525581
True,compatible,,True,True,False,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000205301,MGAT4D,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000205301,MGAT4D,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00547511
True,compatible,,True,True,True,,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,ENSG00000205301,MGAT4D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000205359,SLCO6A1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000205359,SLCO6A1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,ENSG00000205359,SLCO6A1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205409,OR52E6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205409,OR52E6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205409,OR52E6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205442,IZUMO3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205442,IZUMO3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205442,IZUMO3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,14.6,"skin: 14.6 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205445,KRTAP10-2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,14.6,"skin: 14.6 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205445,KRTAP10-2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,14.6,"skin: 14.6 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205445,KRTAP10-2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2,0.7,0.2,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus,ENSG00000205456,TP53TG3D,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 83.0189% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.6154% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.7500% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.6154% (minimum 99%, Baseline (adaptation disabled)); colon: 95.6522% (minimum 97%, Baseline (adaptation disabled)); esophagus: 86.2745% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.6170% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 84.6154% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.7959% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7778% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.6170% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7778% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 89.7959% (minimum 99%, Baseline (adaptation disabled)); retina: 97.7778% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.7778% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.7778% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.4815% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 95.6522% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2,0.7,0.2,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus,ENSG00000205456,TP53TG3D,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.00652174,-0.107255,-0.3025
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 83.0189% (minimum 99%, Missing); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 84.6154% (minimum 99%, Missing); cerebellum: 68.7500% (minimum 99%, Missing); cerebral cortex: 84.6154% (minimum 99%, Missing); colon: 95.6522% (minimum 97%, Missing); esophagus: 86.2745% (minimum 97%, Missing); heart muscle: 93.6170% (minimum 99%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 84.6154% (minimum 99%, Missing); kidney: 89.7959% (minimum 99%, Missing); lung: 97.7778% (minimum 99%, Missing); lymph node: 93.6170% (minimum 97%, Missing); midbrain: 88.0000% (minimum 99%, Missing); pancreas: 97.7778% (minimum 99%, Missing); pituitary gland: 89.7959% (minimum 99%, Missing); retina: 97.7778% (minimum 99%, Missing); small intestine: 97.7778% (minimum 99%, Missing); smooth muscle: 97.7778% (minimum 99%, Missing); spinal cord: 81.4815% (minimum 99%, Missing); urinary bladder: 95.6522% (minimum 97%, Missing)",0,80,unavailable,2,0.7,0.2,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus,ENSG00000205456,TP53TG3D,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.00652174,-0.107255,-0.3025
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000205457,TP53TG3C,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000205457,TP53TG3C,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.39
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"kidney: 75.0000% (minimum 99%, Missing); pancreas: 60.0000% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000205457,TP53TG3C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.39
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,11.7,0,0.3,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; spleen / cells in red pulp; tonsil; tonsil / germinal center cells,ENSG00000205639,MFSD2B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.4286% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 4.0984% (minimum 99%, Baseline (adaptation disabled)); duodenum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 71.4286% (minimum 99%, Baseline (adaptation disabled)); retina: 83.3333% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,11.7,0,0.3,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; spleen / cells in red pulp; tonsil; tonsil / germinal center cells,ENSG00000205639,MFSD2B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.325,0.03,-0.949016
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.4286% (minimum 99%, Missing); bone marrow: 4.0984% (minimum 99%, Missing); duodenum: 83.3333% (minimum 95%, Enhanced); lung: 71.4286% (minimum 95%, Enhanced); retina: 83.3333% (minimum 99%, Missing); skeletal muscle: 83.3333% (minimum 95%, Enhanced); spleen: 62.5000% (minimum 95%, Missing)",0,4,partial,11.7,0,0.3,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; spleen / cells in red pulp; tonsil; tonsil / germinal center cells,ENSG00000205639,MFSD2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.325,0.03,-0.949016
True,compatible,,True,True,False,,0,7,partial,0.4,0,0.1,,,50,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205642,VCX3B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 97.2414% (minimum 99%, Baseline (adaptation disabled))",0,7,partial,0.4,0,0.1,,,50,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205642,VCX3B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0429577,0.03,-0.0175862
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 97.2414% (minimum 99%, Missing)",0,7,partial,0.4,0,0.1,,,50,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205642,VCX3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0429577,0.03,-0.0175862
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,119.5,131918,9.7,"salivary gland: 131918 nTPM (protected, limit 2); pancreas: 119.5 nTPM (vital, limit 6); heart muscle: 25.2 nTPM (vital, limit 6); bone marrow: 18.7 nTPM (vital, limit 6); pituitary gland: 1.7 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000205649,HTN3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 40.2556% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.9231% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.4375% (minimum 99%, Baseline (adaptation disabled)); colon: 84.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.6744% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 33.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 98.4375% (minimum 99%, Baseline (adaptation disabled)); pancreas: 9.5382% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 88.1119% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.7468% (minimum 97%, Baseline (adaptation disabled)); retina: 95.4545% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 0.0096% (minimum 97%, Baseline (adaptation disabled)); skin: 56.5022% (minimum 95%, Baseline (adaptation disabled))",0,1,partial,119.5,131918,9.7,"salivary gland: 131918 nTPM (protected, limit 2); pancreas: 119.5 nTPM (vital, limit 1); heart muscle: 25.2 nTPM (vital, limit 1); bone marrow: 18.7 nTPM (vital, limit 1); skin: 9.7 nTPM (manageable, limit 5); rectum: 3.2 nTPM (protected, limit 2); colon: 2.4 nTPM (protected, limit 2); pituitary gland: 1.7 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000205649,HTN3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.384978,-0.969904,-0.894618
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 40.2556% (minimum 95%, Enhanced); choroid plexus: 98.4375% (minimum 99%, Missing); heart muscle: 33.3333% (minimum 95%, Enhanced); pancreas: 9.5382% (minimum 95%, Enhanced); pituitary gland: 88.1119% (minimum 99%, Missing); rectum: 79.7468% (minimum 80%, Enhanced); retina: 95.4545% (minimum 99%, Missing); salivary gland: 0.0096% (minimum 97%, Missing); skin: 56.5022% (minimum 60%, Enhanced)",0,1,partial,119.5,131918,9.7,"salivary gland: 131918 nTPM (protected, limit 2); pancreas: 119.5 nTPM (vital, limit 6); heart muscle: 25.2 nTPM (vital, limit 6); bone marrow: 18.7 nTPM (vital, limit 6); pituitary gland: 1.7 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000205649,HTN3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0349776,-0.969904,-0.854618
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,117.6,97.6,41.9,"liver: 117.6 nTPM (vital, limit 2); tongue: 97.6 nTPM (protected, limit 2); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 2); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 2); thyroid gland: 41.9 nTPM (manageable, limit 10); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 4); duodenum: 32.5 nTPM (vital, limit 2); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 2); stomach: 29.5 nTPM (protected, limit 2); salivary gland: 29.5 nTPM (protected, limit 4); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (manageable, limit 10); hypothalamus: 26.1 nTPM (vital, limit 1); skin: 23.6 nTPM (manageable, limit 5); pancreas: 23.3 nTPM (vital, limit 2); small intestine: 23.2 nTPM (vital, limit 2); esophagus: 21.8 nTPM (protected, limit 2); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 4); thymus: 18.4 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 10); smooth muscle: 17.6 nTPM (vital, limit 2); lymph node: 17.5 nTPM (protected, limit 4); urinary bladder: 17.4 nTPM (protected, limit 4); colon: 17.3 nTPM (protected, limit 2); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 2); cerebellum: 10.1 nTPM (vital, limit 2)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000205707,ETFRF1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 66.7482% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.9296% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.1214% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.4676% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.0089% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.3895% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.0094% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.0587% (minimum 99%, Baseline (adaptation disabled)); colon: 75.9388% (minimum 97%, Baseline (adaptation disabled)); duodenum: 62.6866% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.4660% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.6068% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.5623% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.6580% (minimum 99%, Baseline (adaptation disabled)); kidney: 50.3690% (minimum 99%, Baseline (adaptation disabled)); liver: 31.7073% (minimum 99%, Baseline (adaptation disabled)); lung: 72.2222% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.7282% (minimum 97%, Baseline (adaptation disabled)); midbrain: 58.5837% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.0899% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.2649% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.7879% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.3869% (minimum 97%, Baseline (adaptation disabled)); retina: 64.9227% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.9227% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 38.8612% (minimum 99%, Baseline (adaptation disabled)); skin: 69.8210% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.1799% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.6233% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 43.7150% (minimum 99%, Baseline (adaptation disabled)); spleen: 75.4144% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.9227% (minimum 97%, Baseline (adaptation disabled)); thymus: 74.7945% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.5803% (minimum 95%, Baseline (adaptation disabled)); tongue: 35.8739% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.8333% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,117.6,97.6,41.9,"liver: 117.6 nTPM (vital, limit 1); tongue: 97.6 nTPM (protected, limit 2); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 1); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 1); thyroid gland: 41.9 nTPM (manageable, limit 5); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 2); duodenum: 32.5 nTPM (vital, limit 1); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 2); salivary gland: 29.5 nTPM (protected, limit 2); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (manageable, limit 5); hypothalamus: 26.1 nTPM (vital, limit 1); skin: 23.6 nTPM (manageable, limit 5); pancreas: 23.3 nTPM (vital, limit 1); small intestine: 23.2 nTPM (vital, limit 1); esophagus: 21.8 nTPM (protected, limit 2); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 2); thymus: 18.4 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); smooth muscle: 17.6 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 2); urinary bladder: 17.4 nTPM (protected, limit 2); colon: 17.3 nTPM (protected, limit 2); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000205707,ETFRF1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.384197,-0.611261,-0.672927
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 66.7482% (minimum 90%, Approved); adrenal gland: 54.9296% (minimum 98%, Approved); amygdala: 63.1214% (minimum 99%, Missing); basal ganglia: 65.4676% (minimum 99%, Missing); bone marrow: 81.0089% (minimum 98%, Approved); cerebellum: 84.3895% (minimum 98%, Approved); cerebral cortex: 64.0094% (minimum 98%, Approved); choroid plexus: 80.0587% (minimum 99%, Missing); colon: 75.9388% (minimum 97%, Missing); duodenum: 62.6866% (minimum 98%, Approved); esophagus: 71.4660% (minimum 97%, Missing); heart muscle: 51.6068% (minimum 99%, Missing); hippocampal formation: 63.5623% (minimum 99%, Missing); hypothalamus: 67.6580% (minimum 99%, Missing); kidney: 50.3690% (minimum 98%, Approved); liver: 31.7073% (minimum 98%, Approved); lung: 72.2222% (minimum 99%, Missing); lymph node: 75.7282% (minimum 95%, Approved); midbrain: 58.5837% (minimum 99%, Missing); pancreas: 70.0899% (minimum 98%, Approved); parathyroid gland: 60.2649% (minimum 95%, Approved); pituitary gland: 78.7879% (minimum 99%, Missing); rectum: 74.3869% (minimum 95%, Approved); retina: 64.9227% (minimum 99%, Missing); salivary gland: 64.9227% (minimum 95%, Approved); skeletal muscle: 38.8612% (minimum 99%, Missing); skin: 69.8210% (minimum 95%, Missing); small intestine: 70.1799% (minimum 98%, Approved); smooth muscle: 75.6233% (minimum 98%, Approved); spinal cord: 43.7150% (minimum 99%, Missing); spleen: 75.4144% (minimum 90%, Approved); stomach: 64.9227% (minimum 97%, Missing); thymus: 74.7945% (minimum 95%, Missing); thyroid gland: 56.5803% (minimum 90%, Approved); tongue: 35.8739% (minimum 97%, Missing); urinary bladder: 75.8333% (minimum 95%, Approved)",0,3,partial,117.6,97.6,41.9,"liver: 117.6 nTPM (vital, limit 2); tongue: 97.6 nTPM (protected, limit 2); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 2); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 2); thyroid gland: 41.9 nTPM (manageable, limit 10); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 4); duodenum: 32.5 nTPM (vital, limit 2); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 2); stomach: 29.5 nTPM (protected, limit 2); salivary gland: 29.5 nTPM (protected, limit 4); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (manageable, limit 10); hypothalamus: 26.1 nTPM (vital, limit 1); skin: 23.6 nTPM (manageable, limit 5); pancreas: 23.3 nTPM (vital, limit 2); small intestine: 23.2 nTPM (vital, limit 2); esophagus: 21.8 nTPM (protected, limit 2); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 4); thymus: 18.4 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 10); smooth muscle: 17.6 nTPM (vital, limit 2); lymph node: 17.5 nTPM (protected, limit 4); urinary bladder: 17.4 nTPM (protected, limit 4); colon: 17.3 nTPM (protected, limit 2); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 2); cerebellum: 10.1 nTPM (vital, limit 2)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000205707,ETFRF1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.334197,-0.611261,-0.662927
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205718,MBD3L4,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205718,MBD3L4,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205718,MBD3L4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,4,partial,0.5,0,0,,,52,not_established,not_triggered,,,ENSG00000205777,GAGE1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Seager 2024;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 78.2609% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,0.5,0,0,,,52,not_established,not_triggered,,,ENSG00000205777,GAGE1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,-0.207391
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 78.2609% (minimum 99%, Missing)",0,4,partial,0.5,0,0,,,52,not_established,not_triggered,,,ENSG00000205777,GAGE1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,-0.207391
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,1.7,2.1,"bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205784,ARRDC5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.1602% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.0588% (minimum 99%, Baseline (adaptation disabled)); lung: 97.0588% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.6593% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.8024% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.8276% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2143% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.7097% (minimum 95%, Baseline (adaptation disabled)); thymus: 91.1602% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.6,1.7,2.1,"bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205784,ARRDC5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0629032,-0.0634066,-0.0783978
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 91.1602% (minimum 99%, Missing); choroid plexus: 97.0588% (minimum 99%, Missing); lung: 97.0588% (minimum 99%, Missing); lymph node: 90.6593% (minimum 97%, Missing); midbrain: 98.8024% (minimum 99%, Missing); small intestine: 94.8276% (minimum 99%, Missing); spinal cord: 98.2143% (minimum 99%, Missing); spleen: 88.7097% (minimum 95%, Missing); thymus: 91.1602% (minimum 95%, Missing)",0,80,unavailable,1.6,1.7,2.1,"bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205784,ARRDC5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0629032,-0.0634066,-0.0783978
True,compatible,,True,True,False,,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000205832,C16orf96,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 96.2264% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.3271% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0769% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.2264% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.2264% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.2264% (minimum 99%, Baseline (adaptation disabled)); liver: 97.1429% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.3271% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.2264% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.0769% (minimum 99%, Baseline (adaptation disabled)); retina: 96.2264% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.4444% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000205832,C16orf96,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,0.0214286,0.0202913,-0.0455556
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 96.2264% (minimum 99%, Missing); basal ganglia: 95.3271% (minimum 99%, Missing); cerebellum: 98.0769% (minimum 99%, Missing); cerebral cortex: 96.2264% (minimum 99%, Missing); hippocampal formation: 96.2264% (minimum 99%, Missing); hypothalamus: 96.2264% (minimum 99%, Missing); liver: 97.1429% (minimum 99%, Missing); midbrain: 95.3271% (minimum 99%, Missing); pancreas: 96.2264% (minimum 99%, Missing); pituitary gland: 98.0769% (minimum 99%, Missing); retina: 96.2264% (minimum 99%, Missing); spinal cord: 94.4444% (minimum 99%, Missing)",0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000205832,C16orf96,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,0.0214286,0.0202913,-0.0455556
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4,0,0,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000205835,GMNC,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.7342% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.8972% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.7342% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.7342% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.1220% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.2500% (minimum 99%, Baseline (adaptation disabled)); liver: 66.1017% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.1220% (minimum 99%, Baseline (adaptation disabled)); retina: 96.2963% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,4,0,0,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000205835,GMNC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,0.03,-0.328983
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.7342% (minimum 99%, Missing); choroid plexus: 72.8972% (minimum 99%, Missing); heart muscle: 98.7342% (minimum 99%, Missing); hippocampal formation: 98.7342% (minimum 99%, Missing); hypothalamus: 95.1220% (minimum 99%, Missing); kidney: 81.2500% (minimum 99%, Missing); liver: 66.1017% (minimum 99%, Missing); pancreas: 95.1220% (minimum 99%, Missing); retina: 96.2963% (minimum 99%, Missing); smooth muscle: 92.8571% (minimum 99%, Missing)",0,80,unavailable,4,0,0,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000205835,GMNC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,0.03,-0.328983
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,1.4,0.8,0.9,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205838,TTC23L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.8037% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.6959% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.6959% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.2222% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.6047% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.1481% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.6959% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6047% (minimum 99%, Baseline (adaptation disabled)); lung: 98.6047% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.3636% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.3636% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.3636% (minimum 99%, Baseline (adaptation disabled)); retina: 93.8053% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.2477% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,1.4,0.8,0.9,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205838,TTC23L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00927602,-0.00636364,-0.0519469
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 97.6959% (minimum 99%, Missing); choroid plexus: 94.2222% (minimum 99%, Missing); hippocampal formation: 98.1481% (minimum 99%, Missing); hypothalamus: 97.6959% (minimum 99%, Missing); pituitary gland: 96.3636% (minimum 99%, Missing); retina: 93.8053% (minimum 99%, Missing)",0,2,partial,1.4,0.8,0.9,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000205838,TTC23L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0406542,0.03,-0.0519469
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,9.3,0.3,0,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),53,not_established,not_triggered,,,ENSG00000205856,C22orf42,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 52.5510% (minimum 99%, Baseline (adaptation disabled)); midbrain: 94.4954% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.2617% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.7928% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0952% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,9.3,0.3,0,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),53,not_established,not_triggered,,,ENSG00000205856,C22orf42,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,0.05,0.00169811,-0.46449
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 52.5510% (minimum 99%, Missing); midbrain: 94.4954% (minimum 99%, Missing); pituitary gland: 92.7928% (minimum 99%, Missing); spinal cord: 98.0952% (minimum 99%, Missing)",0,3,partial,9.3,0.3,0,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),53,not_established,not_triggered,,,ENSG00000205856,C22orf42,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.46449
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205858,LRRC72,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205858,LRRC72,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000205858,LRRC72,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.3,0,,,0,not_established,not_triggered,,,ENSG00000205882,DEFB134,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.7903% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.7903% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.3,0,,,0,not_established,not_triggered,,,ENSG00000205882,DEFB134,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,0.05,0.0179032,-0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.7903% (minimum 99%, Missing); pancreas: 98.0000% (minimum 99%, Missing); pituitary gland: 98.7903% (minimum 99%, Missing)",0,80,unavailable,0.5,0.3,0,,,0,not_established,not_triggered,,,ENSG00000205882,DEFB134,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,0.05,0.0179032,-0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000205883,DEFB135,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000205883,DEFB135,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00819495
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000205883,DEFB135,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00819495
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,0.1,25.2,0.4,"stomach: 25.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205916,DAZ4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 30.7692% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,0.1,25.2,0.4,"stomach: 25.2 nTPM (protected, limit 2)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205916,DAZ4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.0155172,-0.662308,0.00115044
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 30.7692% (minimum 95%, Approved)",0,1,partial,0.1,25.2,0.4,"stomach: 25.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205916,DAZ4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,-0.642308,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,0,5.2,0.2,"stomach: 5.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205944,DAZ2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 93.5484% (minimum 95%, Baseline (adaptation disabled)); stomach: 35.8025% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,0,5.2,0.2,"stomach: 5.2 nTPM (protected, limit 2)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205944,DAZ2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,-0.0145161,-0.611975,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 35.8025% (minimum 95%, Approved)",0,1,partial,0,5.2,0.2,"stomach: 5.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000205944,DAZ2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.0354839,-0.591975,0.01
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000206026,SMIM21,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000206026,SMIM21,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000206026,SMIM21,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000206043,C18orf63,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000206043,C18orf63,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000206043,C18orf63,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,21.6,12.1,2.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 4); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 2); liver: 2.3 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000206052,DOK6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.8235% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.4762% (minimum 99%, Baseline (adaptation disabled)); amygdala: 25.9091% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 44.8819% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.2759% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 52.7778% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 24.3590% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.0625% (minimum 99%, Baseline (adaptation disabled)); colon: 90.4762% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.0625% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 48.7179% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 30.1587% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 44.5312% (minimum 99%, Baseline (adaptation disabled)); kidney: 54.8077% (minimum 99%, Baseline (adaptation disabled)); liver: 71.2500% (minimum 99%, Baseline (adaptation disabled)); lung: 71.2500% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.9355% (minimum 97%, Baseline (adaptation disabled)); midbrain: 38.2550% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.6102% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 32.0225% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.4762% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.9355% (minimum 97%, Baseline (adaptation disabled)); retina: 20.8791% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.6923% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.2759% (minimum 99%, Baseline (adaptation disabled)); skin: 93.4426% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.9355% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.3704% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 75.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.3636% (minimum 95%, Baseline (adaptation disabled)); stomach: 89.0625% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 72.1519% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.9355% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.5172% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,21.6,12.1,2.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 2); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); smooth muscle: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000206052,DOK6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.228481,-0.649775,-0.781209
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 83.8235% (minimum 90%, Approved); adrenal gland: 90.4762% (minimum 99%, Missing); amygdala: 25.9091% (minimum 99%, Missing); basal ganglia: 44.8819% (minimum 99%, Missing); cerebellum: 52.7778% (minimum 99%, Missing); cerebral cortex: 24.3590% (minimum 99%, Missing); choroid plexus: 89.0625% (minimum 99%, Missing); colon: 90.4762% (minimum 97%, Missing); duodenum: 95.0000% (minimum 98%, Approved); esophagus: 89.0625% (minimum 95%, Approved); heart muscle: 48.7179% (minimum 99%, Missing); hippocampal formation: 30.1587% (minimum 99%, Missing); hypothalamus: 44.5312% (minimum 99%, Missing); kidney: 54.8077% (minimum 99%, Missing); liver: 71.2500% (minimum 98%, Approved); lung: 71.2500% (minimum 99%, Missing); lymph node: 91.9355% (minimum 97%, Missing); midbrain: 38.2550% (minimum 99%, Missing); pancreas: 96.6102% (minimum 98%, Approved); parathyroid gland: 32.0225% (minimum 95%, Approved); pituitary gland: 90.4762% (minimum 99%, Missing); rectum: 91.9355% (minimum 95%, Approved); retina: 20.8791% (minimum 99%, Missing); salivary gland: 87.6923% (minimum 95%, Approved); skin: 93.4426% (minimum 95%, Missing); small intestine: 91.9355% (minimum 98%, Approved); smooth muscle: 70.3704% (minimum 98%, Approved); spinal cord: 75.0000% (minimum 99%, Missing); spleen: 86.3636% (minimum 95%, Missing); stomach: 89.0625% (minimum 95%, Approved); thyroid gland: 72.1519% (minimum 90%, Approved); tongue: 91.9355% (minimum 97%, Missing); urinary bladder: 65.5172% (minimum 95%, Approved)",0,0,routine_complete,21.6,12.1,2.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 4); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 2); liver: 2.3 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000206052,DOK6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.178481,-0.629775,-0.781209
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000206102,KRTAP19-8,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 66.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000206102,KRTAP19-8,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.15,0.03,-0.323333
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 66.6667% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing)",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000206102,KRTAP19-8,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.15,0.03,-0.323333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.5,0.1,0.2,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000206113,CFAP99,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 87.9310% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.2264% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.7273% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.4444% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.0769% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.1053% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.7273% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.0714% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.2264% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0769% (minimum 99%, Baseline (adaptation disabled)); lung: 89.4737% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.4444% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 87.9310% (minimum 99%, Baseline (adaptation disabled)); retina: 78.4615% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.0769% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.5,0.1,0.2,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000206113,CFAP99,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0122642,0.0107692,-0.318947
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 87.9310% (minimum 99%, Missing); amygdala: 96.2264% (minimum 99%, Missing); basal ganglia: 92.7273% (minimum 99%, Missing); cerebellum: 94.4444% (minimum 99%, Missing); cerebral cortex: 98.0769% (minimum 99%, Missing); choroid plexus: 67.1053% (minimum 99%, Missing); hippocampal formation: 92.7273% (minimum 99%, Missing); hypothalamus: 91.0714% (minimum 99%, Missing); kidney: 96.2264% (minimum 99%, Missing); liver: 98.0769% (minimum 99%, Missing); lung: 89.4737% (minimum 99%, Missing); pancreas: 94.4444% (minimum 99%, Missing); pituitary gland: 87.9310% (minimum 99%, Missing); retina: 78.4615% (minimum 99%, Missing); spinal cord: 98.0769% (minimum 99%, Missing)",0,80,unavailable,2.5,0.1,0.2,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000206113,CFAP99,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0122642,0.0107692,-0.318947
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.8,2.9,0.5,"salivary gland: 2.9 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000206150,RNASE13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,0.8,2.9,0.5,"salivary gland: 2.9 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000206150,RNASE13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.0483339,0.0204132,0.00733688
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,0.8,2.9,0.5,"salivary gland: 2.9 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000206150,RNASE13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.0483339,0.0204132,0.00733688
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,2,partial,0,0,0,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / germinal center cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000206181,ELOA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,0,0,0,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / germinal center cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000206181,ELOA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,2,partial,0,0,0,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / germinal center cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,ENSG00000206181,ELOA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000206203,TSSK2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000206203,TSSK2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0492436,0.03,0.00622926
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,ENSG00000206203,TSSK2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0492436,0.03,0.00622926
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000206260,PRR23A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 93.7500% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000206260,PRR23A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.0525
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 93.7500% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000206260,PRR23A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.0525
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,8.4,4.8,3.1,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); pancreas: 3.6 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000206530,CFAP44,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 80.4878% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.1892% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.6154% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.1892% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.9677% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.8421% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 52.8000% (minimum 99%, Baseline (adaptation disabled)); colon: 71.7391% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.4110% (minimum 99%, Baseline (adaptation disabled)); esophagus: 80.4878% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.4878% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 84.6154% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 83.5443% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.5714% (minimum 99%, Baseline (adaptation disabled)); liver: 76.7442% (minimum 99%, Baseline (adaptation disabled)); lung: 73.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.6154% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.9577% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.7059% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 77.6471% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 51.9685% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 44.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 57.8947% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.5443% (minimum 99%, Baseline (adaptation disabled)); skin: 74.1573% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.2128% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.4110% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.1892% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.6471% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.4737% (minimum 97%, Baseline (adaptation disabled)); thymus: 82.5000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 68.0412% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.6522% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 74.1573% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,8.4,4.8,3.1,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); pancreas: 3.6 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000206530,CFAP44,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.269588,-0.391053,-0.55
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 80.4878% (minimum 95%, Uncertain); adrenal gland: 85.7143% (minimum 99%, Uncertain); amygdala: 89.1892% (minimum 99%, Missing); basal ganglia: 84.6154% (minimum 99%, Missing); bone marrow: 89.1892% (minimum 99%, Uncertain); cerebellum: 70.9677% (minimum 99%, Uncertain); cerebral cortex: 86.8421% (minimum 99%, Missing); choroid plexus: 52.8000% (minimum 99%, Missing); colon: 71.7391% (minimum 97%, Uncertain); duodenum: 90.4110% (minimum 99%, Uncertain); esophagus: 80.4878% (minimum 97%, Uncertain); heart muscle: 80.4878% (minimum 99%, Uncertain); hippocampal formation: 84.6154% (minimum 99%, Missing); hypothalamus: 83.5443% (minimum 99%, Missing); kidney: 78.5714% (minimum 99%, Uncertain); liver: 76.7442% (minimum 99%, Uncertain); lung: 73.3333% (minimum 99%, Uncertain); lymph node: 84.6154% (minimum 97%, Uncertain); midbrain: 92.9577% (minimum 99%, Missing); pancreas: 64.7059% (minimum 99%, Uncertain); parathyroid gland: 77.6471% (minimum 97%, Uncertain); pituitary gland: 51.9685% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Uncertain); retina: 44.0000% (minimum 99%, Missing); salivary gland: 57.8947% (minimum 97%, Uncertain); skeletal muscle: 83.5443% (minimum 99%, Uncertain); skin: 74.1573% (minimum 95%, Missing); small intestine: 70.2128% (minimum 99%, Uncertain); smooth muscle: 90.4110% (minimum 99%, Uncertain); spinal cord: 89.1892% (minimum 99%, Missing); spleen: 77.6471% (minimum 95%, Missing); stomach: 69.4737% (minimum 97%, Uncertain); thymus: 82.5000% (minimum 95%, Missing); thyroid gland: 68.0412% (minimum 95%, Uncertain); tongue: 95.6522% (minimum 97%, Missing); urinary bladder: 74.1573% (minimum 97%, Uncertain)",0,1,partial,8.4,4.8,3.1,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 2); pancreas: 3.6 nTPM (vital, limit 1); stomach: 2.9 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); rectum: 2.2 nTPM (protected, limit 2); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,ENSG00000206530,CFAP44,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.269588,-0.391053,-0.55
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000206531,CD200R1L,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000206531,CD200R1L,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000206531,CD200R1L,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000206557,TRIM71,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 94.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.0370% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.9184% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.9184% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.4545% (minimum 99%, Baseline (adaptation disabled)); lung: 87.0370% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 95.9184% (minimum 99%, Baseline (adaptation disabled)); retina: 94.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000206557,TRIM71,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,0.05,0.03,-0.135455
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 94.0000% (minimum 99%, Missing); basal ganglia: 87.0370% (minimum 99%, Missing); bone marrow: 95.9184% (minimum 99%, Missing); cerebral cortex: 94.0000% (minimum 99%, Missing); hippocampal formation: 95.9184% (minimum 99%, Missing); hypothalamus: 94.0000% (minimum 99%, Missing); kidney: 85.4545% (minimum 99%, Missing); lung: 87.0370% (minimum 99%, Missing); pituitary gland: 95.9184% (minimum 99%, Missing); retina: 94.0000% (minimum 99%, Missing)",0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,ENSG00000206557,TRIM71,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;da Silva 2017,0.05,0.03,-0.135455
True,compatible,,True,True,False,,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000212122,TSSK1B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000212122,TSSK1B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0461759,0.03,0.00808429
True,compatible,,True,True,True,,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000212122,TSSK1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00808429
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,5,partial,11.6,4.9,6.3,"liver: 11.6 nTPM (vital, limit 6); kidney: 6.9 nTPM (vital, limit 6); pancreas: 6.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); pituitary gland: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000212123,PRR22,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.9318% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.0154% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.0605% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.2451% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.5631% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.2950% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7912% (minimum 99%, Baseline (adaptation disabled)); colon: 92.7619% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.3033% (minimum 99%, Baseline (adaptation disabled)); esophagus: 91.0280% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.1172% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.2950% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.7471% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.5899% (minimum 99%, Baseline (adaptation disabled)); liver: 80.7629% (minimum 99%, Baseline (adaptation disabled)); lung: 95.6778% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.1172% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.8686% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.9389% (minimum 99%, Baseline (adaptation disabled)); retina: 98.5830% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 90.8582% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 97.4000% (minimum 99%, Baseline (adaptation disabled)); skin: 89.3578% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.5221% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.5631% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.5455% (minimum 95%, Baseline (adaptation disabled)); stomach: 92.5856% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 89.1941% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.4902% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,11.6,4.9,6.3,"liver: 11.6 nTPM (vital, limit 1); kidney: 6.9 nTPM (vital, limit 1); spleen: 6.3 nTPM (manageable, limit 5); pancreas: 6.1 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 4.9 nTPM (protected, limit 2); esophagus: 4.8 nTPM (protected, limit 2); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 2); colon: 3.8 nTPM (protected, limit 2); pituitary gland: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000212123,PRR22,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.0645455,-0.0614179,-0.182371
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.9318% (minimum 95%, Enhanced); amygdala: 94.0154% (minimum 99%, Missing); basal ganglia: 92.0605% (minimum 99%, Missing); cerebellum: 94.5631% (minimum 95%, Enhanced); cerebral cortex: 93.2950% (minimum 95%, Enhanced); choroid plexus: 97.7912% (minimum 99%, Missing); colon: 92.7619% (minimum 97%, Missing); hippocampal formation: 93.2950% (minimum 99%, Missing); hypothalamus: 94.7471% (minimum 99%, Missing); kidney: 87.5899% (minimum 95%, Enhanced); liver: 80.7629% (minimum 95%, Enhanced); midbrain: 95.1172% (minimum 99%, Missing); pancreas: 88.8686% (minimum 99%, Missing); pituitary gland: 92.9389% (minimum 99%, Missing); retina: 98.5830% (minimum 99%, Missing); small intestine: 89.5221% (minimum 95%, Enhanced); spinal cord: 94.5631% (minimum 99%, Missing)",0,5,partial,11.6,4.9,6.3,"liver: 11.6 nTPM (vital, limit 6); kidney: 6.9 nTPM (vital, limit 6); pancreas: 6.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); pituitary gland: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000212123,PRR22,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.0338384,-0.042381,-0.142371
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000212710,CTAGE1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000212710,CTAGE1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000212710,CTAGE1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,2.8,2.2,3.1,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 2); lymph node: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000212916,MAP10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.2857% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 76.4706% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.7879% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 68.4211% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.2500% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 76.4706% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 55.3191% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.2963% (minimum 99%, Baseline (adaptation disabled)); colon: 76.4706% (minimum 97%, Baseline (adaptation disabled)); duodenum: 70.2703% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.6667% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 55.3191% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 76.4706% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.2857% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.2857% (minimum 99%, Baseline (adaptation disabled)); liver: 54.1667% (minimum 99%, Baseline (adaptation disabled)); lung: 72.2222% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.1667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.2500% (minimum 99%, Baseline (adaptation disabled)); pancreas: 60.4651% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 81.2500% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 78.7879% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.7879% (minimum 97%, Baseline (adaptation disabled)); retina: 48.1481% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 55.3191% (minimum 99%, Baseline (adaptation disabled)); skin: 89.6552% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.4146% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.2222% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 81.2500% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.4211% (minimum 95%, Baseline (adaptation disabled)); stomach: 66.6667% (minimum 97%, Baseline (adaptation disabled)); thymus: 45.6140% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.0909% (minimum 95%, Baseline (adaptation disabled)); tongue: 68.4211% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.4706% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,2.8,2.2,3.1,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000212916,MAP10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.49386,-0.428333,-0.508519
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 74.2857% (minimum 90%, Approved); adrenal gland: 76.4706% (minimum 99%, Missing); amygdala: 78.7879% (minimum 99%, Missing); basal ganglia: 68.4211% (minimum 99%, Missing); bone marrow: 81.2500% (minimum 99%, Missing); cerebellum: 76.4706% (minimum 99%, Missing); cerebral cortex: 55.3191% (minimum 99%, Missing); choroid plexus: 96.2963% (minimum 99%, Missing); colon: 76.4706% (minimum 97%, Missing); duodenum: 70.2703% (minimum 99%, Missing); esophagus: 86.6667% (minimum 97%, Missing); heart muscle: 55.3191% (minimum 99%, Missing); hippocampal formation: 76.4706% (minimum 99%, Missing); hypothalamus: 74.2857% (minimum 99%, Missing); kidney: 74.2857% (minimum 99%, Missing); liver: 54.1667% (minimum 98%, Approved); lung: 72.2222% (minimum 99%, Missing); lymph node: 54.1667% (minimum 97%, Missing); midbrain: 81.2500% (minimum 99%, Missing); pancreas: 60.4651% (minimum 99%, Missing); parathyroid gland: 81.2500% (minimum 97%, Missing); pituitary gland: 78.7879% (minimum 99%, Missing); rectum: 78.7879% (minimum 97%, Missing); retina: 48.1481% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 55.3191% (minimum 99%, Missing); skin: 89.6552% (minimum 95%, Missing); small intestine: 63.4146% (minimum 99%, Missing); smooth muscle: 72.2222% (minimum 99%, Missing); spinal cord: 81.2500% (minimum 99%, Missing); spleen: 68.4211% (minimum 90%, Approved); stomach: 66.6667% (minimum 97%, Missing); thymus: 45.6140% (minimum 95%, Missing); thyroid gland: 59.0909% (minimum 95%, Missing); tongue: 68.4211% (minimum 97%, Missing); urinary bladder: 76.4706% (minimum 97%, Missing)",0,2,partial,2.8,2.2,3.1,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 2); lymph node: 2.2 nTPM (protected, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000212916,MAP10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.49386,-0.428333,-0.508519
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000212933,KRTAP12-4,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000212933,KRTAP12-4,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000212933,KRTAP12-4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.1,3.4,4.2,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213020,ZNF611,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.7917% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.7073% (minimum 99%, Baseline (adaptation disabled)); amygdala: 80.7229% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.0430% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.3366% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.0430% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.5263% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.8101% (minimum 99%, Baseline (adaptation disabled)); colon: 72.0430% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.4444% (minimum 99%, Baseline (adaptation disabled)); esophagus: 81.7073% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.5263% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.8235% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.9070% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.8095% (minimum 99%, Baseline (adaptation disabled)); liver: 79.7619% (minimum 99%, Baseline (adaptation disabled)); lung: 69.7917% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.3366% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.7073% (minimum 99%, Baseline (adaptation disabled)); pancreas: 62.0370% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 70.5263% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.2809% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.0722% (minimum 97%, Baseline (adaptation disabled)); retina: 62.0370% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.0115% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.7073% (minimum 99%, Baseline (adaptation disabled)); skin: 79.7619% (minimum 95%, Baseline (adaptation disabled)); small intestine: 77.9070% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.3673% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.9070% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.6863% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.0430% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.4679% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 63.8095% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.8235% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 73.6264% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.1,3.4,4.2,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213020,ZNF611,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.335321,-0.306634,-0.36963
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 69.7917% (minimum 95%, Missing); adrenal gland: 81.7073% (minimum 99%, Missing); amygdala: 80.7229% (minimum 99%, Missing); basal ganglia: 72.0430% (minimum 99%, Missing); bone marrow: 66.3366% (minimum 99%, Missing); cerebellum: 72.0430% (minimum 99%, Missing); cerebral cortex: 70.5263% (minimum 99%, Missing); choroid plexus: 84.8101% (minimum 99%, Missing); colon: 72.0430% (minimum 97%, Missing); duodenum: 74.4444% (minimum 99%, Missing); esophagus: 81.7073% (minimum 97%, Missing); heart muscle: 70.5263% (minimum 99%, Missing); hippocampal formation: 78.8235% (minimum 99%, Missing); hypothalamus: 77.9070% (minimum 99%, Missing); kidney: 63.8095% (minimum 99%, Missing); liver: 79.7619% (minimum 99%, Missing); lung: 69.7917% (minimum 99%, Missing); lymph node: 66.3366% (minimum 97%, Missing); midbrain: 81.7073% (minimum 99%, Missing); pancreas: 62.0370% (minimum 99%, Missing); parathyroid gland: 70.5263% (minimum 97%, Missing); pituitary gland: 75.2809% (minimum 99%, Missing); rectum: 69.0722% (minimum 97%, Missing); retina: 62.0370% (minimum 99%, Missing); salivary gland: 77.0115% (minimum 97%, Missing); skeletal muscle: 81.7073% (minimum 99%, Missing); skin: 79.7619% (minimum 95%, Missing); small intestine: 77.9070% (minimum 99%, Missing); smooth muscle: 68.3673% (minimum 99%, Missing); spinal cord: 77.9070% (minimum 99%, Missing); spleen: 65.6863% (minimum 95%, Missing); stomach: 72.0430% (minimum 97%, Missing); thymus: 61.4679% (minimum 95%, Missing); thyroid gland: 63.8095% (minimum 95%, Missing); tongue: 78.8235% (minimum 97%, Missing); urinary bladder: 73.6264% (minimum 97%, Missing)",0,80,unavailable,4.1,3.4,4.2,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); rectum: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); parathyroid gland: 2.8 nTPM (protected, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); colon: 2.6 nTPM (protected, limit 2); urinary bladder: 2.4 nTPM (protected, limit 2); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213020,ZNF611,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.335321,-0.306634,-0.36963
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,32.4,37.3,39.7,"thymus: 39.7 nTPM (manageable, limit 5); lymph node: 37.3 nTPM (protected, limit 2); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); spleen: 28.7 nTPM (manageable, limit 5); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 2); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 2); duodenum: 22.8 nTPM (vital, limit 1); skin: 22.5 nTPM (manageable, limit 5); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 2); salivary gland: 21.1 nTPM (protected, limit 2); tongue: 20.8 nTPM (protected, limit 2); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 2); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (manageable, limit 5); stomach: 18.8 nTPM (protected, limit 2); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 2); thyroid gland: 15.8 nTPM (manageable, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000213024,NUP62,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.3433% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.7297% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.4020% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.1391% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.8575% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.9776% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.9726% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.6071% (minimum 99%, Baseline (adaptation disabled)); colon: 68.7770% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.7054% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.3889% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.8148% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.0083% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.4800% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.7549% (minimum 99%, Baseline (adaptation disabled)); liver: 60.7370% (minimum 99%, Baseline (adaptation disabled)); lung: 72.0965% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.1692% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.5341% (minimum 99%, Baseline (adaptation disabled)); pancreas: 70.1909% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.6518% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.2857% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.7101% (minimum 97%, Baseline (adaptation disabled)); retina: 82.9861% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.3759% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 59.6010% (minimum 99%, Baseline (adaptation disabled)); skin: 67.9943% (minimum 95%, Baseline (adaptation disabled)); small intestine: 66.9468% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.2473% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.9726% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.4837% (minimum 95%, Baseline (adaptation disabled)); stomach: 71.7718% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.6286% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.1572% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.6793% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.1348% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,32.4,37.3,39.7,"thymus: 39.7 nTPM (manageable, limit 5); lymph node: 37.3 nTPM (protected, limit 2); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); spleen: 28.7 nTPM (manageable, limit 5); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 2); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 2); duodenum: 22.8 nTPM (vital, limit 1); skin: 22.5 nTPM (manageable, limit 5); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 2); salivary gland: 21.1 nTPM (protected, limit 2); tongue: 20.8 nTPM (protected, limit 2); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 2); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (manageable, limit 5); stomach: 18.8 nTPM (protected, limit 2); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 2); thyroid gland: 15.8 nTPM (manageable, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000213024,NUP62,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.403714,-0.408308,-0.39399
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 71.3433% (minimum 95%, Missing); adrenal gland: 62.7297% (minimum 99%, Missing); amygdala: 79.4020% (minimum 99%, Missing); basal ganglia: 79.1391% (minimum 99%, Missing); bone marrow: 64.8575% (minimum 99%, Missing); cerebellum: 62.9776% (minimum 99%, Missing); cerebral cortex: 76.9726% (minimum 99%, Missing); choroid plexus: 80.6071% (minimum 99%, Missing); colon: 68.7770% (minimum 97%, Missing); duodenum: 67.7054% (minimum 99%, Missing); esophagus: 66.3889% (minimum 97%, Missing); heart muscle: 70.8148% (minimum 99%, Missing); hippocampal formation: 79.0083% (minimum 99%, Missing); hypothalamus: 76.4800% (minimum 99%, Missing); kidney: 72.7549% (minimum 99%, Missing); liver: 60.7370% (minimum 99%, Missing); lung: 72.0965% (minimum 99%, Missing); lymph node: 56.1692% (minimum 97%, Missing); midbrain: 79.5341% (minimum 99%, Missing); pancreas: 70.1909% (minimum 99%, Missing); parathyroid gland: 73.6518% (minimum 97%, Missing); pituitary gland: 68.2857% (minimum 99%, Missing); rectum: 70.7101% (minimum 97%, Missing); retina: 82.9861% (minimum 99%, Missing); salivary gland: 69.3759% (minimum 97%, Missing); skeletal muscle: 59.6010% (minimum 99%, Missing); skin: 67.9943% (minimum 95%, Missing); small intestine: 66.9468% (minimum 99%, Missing); smooth muscle: 64.2473% (minimum 99%, Missing); spinal cord: 76.9726% (minimum 99%, Missing); spleen: 62.4837% (minimum 95%, Missing); stomach: 71.7718% (minimum 97%, Missing); thymus: 54.6286% (minimum 95%, Missing); thyroid gland: 75.1572% (minimum 95%, Missing); tongue: 69.6793% (minimum 97%, Missing); urinary bladder: 67.1348% (minimum 97%, Missing)",0,6,partial,32.4,37.3,39.7,"thymus: 39.7 nTPM (manageable, limit 5); lymph node: 37.3 nTPM (protected, limit 2); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); spleen: 28.7 nTPM (manageable, limit 5); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 2); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 2); duodenum: 22.8 nTPM (vital, limit 1); skin: 22.5 nTPM (manageable, limit 5); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 2); salivary gland: 21.1 nTPM (protected, limit 2); tongue: 20.8 nTPM (protected, limit 2); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 2); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (manageable, limit 5); stomach: 18.8 nTPM (protected, limit 2); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 2); thyroid gland: 15.8 nTPM (manageable, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000213024,NUP62,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.403714,-0.408308,-0.39399
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,2.3,0,0,"pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,ENSG00000213030,CGB8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 88.7255% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,2.3,0,0,"pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,ENSG00000213030,CGB8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.102745
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 88.7255% (minimum 99%, Missing)",0,1,partial,2.3,0,0,"pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,ENSG00000213030,CGB8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.102745
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,303.5,131.6,291.8,"small intestine: 303.5 nTPM (vital, limit 1); skin: 291.8 nTPM (manageable, limit 5); adipose tissue: 256.4 nTPM (manageable, limit 5); heart muscle: 253.9 nTPM (vital, limit 2); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (manageable, limit 5); salivary gland: 131.6 nTPM (protected, limit 4); colon: 129.9 nTPM (protected, limit 2); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 4); urinary bladder: 110 nTPM (protected, limit 4); kidney: 106.5 nTPM (vital, limit 1); spleen: 92.2 nTPM (manageable, limit 5); stomach: 91.6 nTPM (protected, limit 2); lymph node: 81.8 nTPM (protected, limit 2); thymus: 77.5 nTPM (manageable, limit 5); rectum: 53.5 nTPM (protected, limit 2); tongue: 48.1 nTPM (protected, limit 2); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 2); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 2); hippocampal formation: 28 nTPM (vital, limit 1); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 2); parathyroid gland: 20.5 nTPM (protected, limit 4); pancreas: 17.7 nTPM (vital, limit 2); liver: 17.4 nTPM (vital, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000213145,CRIP1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.0175% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 90.5660% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.0459% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.1595% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 87.4241% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.5055% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.8604% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.8182% (minimum 99%, Baseline (adaptation disabled)); colon: 60.8145% (minimum 97%, Baseline (adaptation disabled)); duodenum: 63.0788% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.5962% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 44.2591% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.8049% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.3484% (minimum 99%, Baseline (adaptation disabled)); kidney: 65.4333% (minimum 99%, Baseline (adaptation disabled)); liver: 92.0548% (minimum 99%, Baseline (adaptation disabled)); lung: 44.9599% (minimum 99%, Baseline (adaptation disabled)); lymph node: 71.1362% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.8217% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.9289% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.7699% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.3058% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.0278% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 60.5042% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.3529% (minimum 99%, Baseline (adaptation disabled)); skin: 40.8593% (minimum 95%, Baseline (adaptation disabled)); small intestine: 39.9129% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.1683% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.2013% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.6181% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.7585% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.2322% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.3051% (minimum 95%, Baseline (adaptation disabled)); tongue: 80.7369% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.6983% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,303.5,131.6,291.8,"small intestine: 303.5 nTPM (vital, limit 1); skin: 291.8 nTPM (manageable, limit 5); adipose tissue: 256.4 nTPM (manageable, limit 5); heart muscle: 253.9 nTPM (vital, limit 1); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (manageable, limit 5); salivary gland: 131.6 nTPM (protected, limit 2); colon: 129.9 nTPM (protected, limit 2); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 2); urinary bladder: 110 nTPM (protected, limit 2); kidney: 106.5 nTPM (vital, limit 1); spleen: 92.2 nTPM (manageable, limit 5); stomach: 91.6 nTPM (protected, limit 2); lymph node: 81.8 nTPM (protected, limit 2); thymus: 77.5 nTPM (manageable, limit 5); rectum: 53.5 nTPM (protected, limit 2); tongue: 48.1 nTPM (protected, limit 2); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 1); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 1); hippocampal formation: 28 nTPM (vital, limit 1); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 2); pancreas: 17.7 nTPM (vital, limit 1); liver: 17.4 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000213145,CRIP1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.541407,-0.364958,-0.590871
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.0175% (minimum 95%, Missing); adrenal gland: 90.5660% (minimum 98%, Approved); amygdala: 89.0459% (minimum 99%, Missing); basal ganglia: 87.1595% (minimum 99%, Missing); bone marrow: 87.4241% (minimum 98%, Approved); cerebellum: 96.5055% (minimum 98%, Approved); cerebral cortex: 92.8604% (minimum 99%, Missing); choroid plexus: 81.8182% (minimum 99%, Missing); colon: 60.8145% (minimum 97%, Missing); duodenum: 63.0788% (minimum 99%, Missing); esophagus: 63.5962% (minimum 95%, Approved); heart muscle: 44.2591% (minimum 98%, Approved); hippocampal formation: 87.8049% (minimum 99%, Missing); hypothalamus: 87.3484% (minimum 99%, Missing); kidney: 65.4333% (minimum 99%, Missing); liver: 92.0548% (minimum 98%, Approved); lung: 44.9599% (minimum 99%, Missing); lymph node: 71.1362% (minimum 97%, Missing); midbrain: 86.8217% (minimum 99%, Missing); pancreas: 91.9289% (minimum 98%, Approved); parathyroid gland: 90.7699% (minimum 95%, Approved); pituitary gland: 83.3058% (minimum 99%, Missing); rectum: 79.0278% (minimum 97%, Missing); salivary gland: 60.5042% (minimum 95%, Approved); skeletal muscle: 82.3529% (minimum 98%, Approved); skin: 40.8593% (minimum 95%, Missing); small intestine: 39.9129% (minimum 99%, Missing); smooth muscle: 83.1683% (minimum 99%, Missing); spinal cord: 90.2013% (minimum 99%, Missing); spleen: 68.6181% (minimum 95%, Missing); stomach: 68.7585% (minimum 97%, Missing); thymus: 72.2322% (minimum 95%, Missing); thyroid gland: 53.3051% (minimum 95%, Missing); tongue: 80.7369% (minimum 97%, Missing); urinary bladder: 64.6983% (minimum 95%, Approved)",0,7,partial,303.5,131.6,291.8,"small intestine: 303.5 nTPM (vital, limit 1); skin: 291.8 nTPM (manageable, limit 5); adipose tissue: 256.4 nTPM (manageable, limit 5); heart muscle: 253.9 nTPM (vital, limit 2); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (manageable, limit 5); salivary gland: 131.6 nTPM (protected, limit 4); colon: 129.9 nTPM (protected, limit 2); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 4); urinary bladder: 110 nTPM (protected, limit 4); kidney: 106.5 nTPM (vital, limit 1); spleen: 92.2 nTPM (manageable, limit 5); stomach: 91.6 nTPM (protected, limit 2); lymph node: 81.8 nTPM (protected, limit 2); thymus: 77.5 nTPM (manageable, limit 5); rectum: 53.5 nTPM (protected, limit 2); tongue: 48.1 nTPM (protected, limit 2); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 2); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 2); hippocampal formation: 28 nTPM (vital, limit 1); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 2); parathyroid gland: 20.5 nTPM (protected, limit 4); pancreas: 17.7 nTPM (vital, limit 2); liver: 17.4 nTPM (vital, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000213145,CRIP1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.541407,-0.361855,-0.590871
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,17,11.8,13.3,"bone marrow: 17 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); lymph node: 11.8 nTPM (protected, limit 2); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); amygdala: 5 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); hypothalamus: 4.2 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213186,TRIM59,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3077% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.3077% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.6866% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.7568% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 33.0709% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 87.5000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 44.6809% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.3820% (minimum 99%, Baseline (adaptation disabled)); colon: 76.3636% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.6757% (minimum 99%, Baseline (adaptation disabled)); esophagus: 64.1221% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.3077% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 48.8372% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 89.3617% (minimum 99%, Baseline (adaptation disabled)); lung: 81.5534% (minimum 99%, Baseline (adaptation disabled)); lymph node: 41.5842% (minimum 97%, Baseline (adaptation disabled)); midbrain: 48.2759% (minimum 99%, Baseline (adaptation disabled)); pancreas: 84.8485% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.1683% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 88.4211% (minimum 99%, Baseline (adaptation disabled)); rectum: 77.0642% (minimum 97%, Baseline (adaptation disabled)); retina: 85.7143% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 84.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); skin: 61.3139% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 75.6757% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 45.6522% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.6866% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.0642% (minimum 97%, Baseline (adaptation disabled)); thymus: 38.7097% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 80.7692% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 73.6842% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,17,11.8,13.3,"bone marrow: 17 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); lymph node: 11.8 nTPM (protected, limit 2); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); amygdala: 5 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); hypothalamus: 4.2 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213186,TRIM59,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.562903,-0.554158,-0.659291
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 92.3077% (minimum 95%, Missing); adrenal gland: 92.3077% (minimum 99%, Missing); amygdala: 62.6866% (minimum 99%, Missing); basal ganglia: 56.7568% (minimum 99%, Missing); bone marrow: 33.0709% (minimum 99%, Missing); cerebellum: 87.5000% (minimum 99%, Missing); cerebral cortex: 44.6809% (minimum 99%, Missing); choroid plexus: 94.3820% (minimum 99%, Missing); colon: 76.3636% (minimum 97%, Missing); duodenum: 75.6757% (minimum 99%, Missing); esophagus: 64.1221% (minimum 97%, Missing); heart muscle: 92.3077% (minimum 99%, Missing); hippocampal formation: 48.8372% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 87.5000% (minimum 99%, Missing); liver: 89.3617% (minimum 99%, Missing); lung: 81.5534% (minimum 99%, Missing); lymph node: 41.5842% (minimum 97%, Missing); midbrain: 48.2759% (minimum 99%, Missing); pancreas: 84.8485% (minimum 99%, Missing); parathyroid gland: 83.1683% (minimum 97%, Missing); pituitary gland: 88.4211% (minimum 99%, Missing); rectum: 77.0642% (minimum 97%, Missing); retina: 85.7143% (minimum 99%, Missing); salivary gland: 84.0000% (minimum 97%, Missing); skeletal muscle: 87.5000% (minimum 99%, Missing); skin: 61.3139% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 75.6757% (minimum 99%, Missing); spinal cord: 45.6522% (minimum 99%, Missing); spleen: 62.6866% (minimum 95%, Missing); stomach: 77.0642% (minimum 97%, Missing); thymus: 38.7097% (minimum 95%, Missing); thyroid gland: 80.7692% (minimum 95%, Missing); urinary bladder: 73.6842% (minimum 97%, Missing)",0,80,unavailable,17,11.8,13.3,"bone marrow: 17 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); lymph node: 11.8 nTPM (protected, limit 2); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); amygdala: 5 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 2); hypothalamus: 4.2 nTPM (vital, limit 1); urinary bladder: 3 nTPM (protected, limit 2); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); colon: 2.6 nTPM (protected, limit 2); rectum: 2.5 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213186,TRIM59,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.562903,-0.554158,-0.659291
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,1.1,1.4,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213213,CCDC183,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7169% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6175% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.3964% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.8326% (minimum 99%, Baseline (adaptation disabled)); colon: 95.9641% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.6175% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.8326% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6175% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1651% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.5357% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.1111% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.8326% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.1111% (minimum 97%, Baseline (adaptation disabled)); retina: 93.0435% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.6175% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.6175% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6175% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.8326% (minimum 97%, Baseline (adaptation disabled)); thymus: 93.8596% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.6,1.1,1.4,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213213,CCDC183,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,-0.0114035,-0.0188889,-0.0595652
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7169% (minimum 99%, Missing); bone marrow: 98.6175% (minimum 99%, Missing); cerebral cortex: 96.3964% (minimum 99%, Missing); choroid plexus: 96.8326% (minimum 99%, Missing); colon: 95.9641% (minimum 97%, Missing); duodenum: 98.6175% (minimum 99%, Missing); heart muscle: 96.8326% (minimum 99%, Missing); kidney: 98.6175% (minimum 99%, Missing); lung: 98.1651% (minimum 99%, Missing); pancreas: 95.5357% (minimum 99%, Missing); parathyroid gland: 95.1111% (minimum 97%, Missing); pituitary gland: 96.8326% (minimum 99%, Missing); rectum: 95.1111% (minimum 97%, Missing); retina: 93.0435% (minimum 99%, Missing); skeletal muscle: 98.6175% (minimum 99%, Missing); small intestine: 98.6175% (minimum 99%, Missing); smooth muscle: 98.6175% (minimum 99%, Missing); stomach: 96.8326% (minimum 97%, Missing); thymus: 93.8596% (minimum 95%, Missing)",0,80,unavailable,1.6,1.1,1.4,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213213,CCDC183,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,-0.0114035,-0.0188889,-0.0595652
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000213215,OR2F1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000213215,OR2F1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000213215,OR2F1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,14.6,5,8.4,"smooth muscle: 14.6 nTPM (vital, limit 3); lung: 3.4 nTPM (vital, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,ENSG00000213218,CSH2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,14.6,5,8.4,"smooth muscle: 14.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 2); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,ENSG00000213218,CSH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.0473803,0.028439,0.00545554
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,1,partial,14.6,5,8.4,"smooth muscle: 14.6 nTPM (vital, limit 3); lung: 3.4 nTPM (vital, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,ENSG00000213218,CSH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.0496874,0.03,0.00940625
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,2.1,0.7,"lymph node: 2.1 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000213231,TCL1B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 69.4444% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 54.3478% (minimum 97%, Baseline (adaptation disabled)); small intestine: 96.1538% (minimum 99%, Baseline (adaptation disabled)); spleen: 78.1250% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.1,2.1,0.7,"lymph node: 2.1 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000213231,TCL1B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.16875,-0.426522,-0.295556
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 69.4444% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); lymph node: 54.3478% (minimum 97%, Missing); small intestine: 96.1538% (minimum 99%, Missing); spleen: 78.1250% (minimum 95%, Missing)",0,80,unavailable,1.1,2.1,0.7,"lymph node: 2.1 nTPM (protected, limit 2); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000213231,TCL1B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.16875,-0.426522,-0.295556
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000213265,TSGA13,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000213265,TSGA13,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000213265,TSGA13,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000213401,MAGEA12,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 90.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 84.3750% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.4286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.1034% (minimum 99%, Baseline (adaptation disabled)); midbrain: 90.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.4286% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000213401,MAGEA12,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,-0.14625
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 90.0000% (minimum 99%, Missing); basal ganglia: 84.3750% (minimum 99%, Missing); cerebellum: 96.4286% (minimum 99%, Missing); cerebral cortex: 90.0000% (minimum 99%, Missing); hippocampal formation: 90.0000% (minimum 99%, Missing); hypothalamus: 93.1034% (minimum 99%, Missing); midbrain: 90.0000% (minimum 99%, Missing); spinal cord: 96.4286% (minimum 99%, Missing)",0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000213401,MAGEA12,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,-0.14625
True,compatible,,True,True,False,,0,4,partial,0.1,0.1,0,,,49,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000213471,TTLL13,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.7500% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7500% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,0.1,0.1,0,,,49,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000213471,TTLL13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.0175,-0.0025
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.7500% (minimum 99%, Missing)",0,4,partial,0.1,0.1,0,,,49,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000213471,TTLL13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.0025
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.7,3.7,3.7,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213588,ZBTB9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.7273% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.4545% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.8182% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.8989% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 72.7273% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.7273% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.4694% (minimum 99%, Baseline (adaptation disabled)); colon: 75.7895% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.7895% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.0550% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.2871% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.2609% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 73.4694% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.6087% (minimum 99%, Baseline (adaptation disabled)); liver: 69.9029% (minimum 99%, Baseline (adaptation disabled)); lung: 75.7895% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 76.5957% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.2871% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.3077% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 42.6036% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.7209% (minimum 97%, Baseline (adaptation disabled)); retina: 80.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.8989% (minimum 99%, Baseline (adaptation disabled)); skin: 66.0550% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.7273% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 91.1392% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.4194% (minimum 99%, Baseline (adaptation disabled)); spleen: 67.9245% (minimum 95%, Baseline (adaptation disabled)); stomach: 73.4694% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 77.4194% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.8049% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.7,3.7,3.7,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213588,ZBTB9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.28945,-0.30945,-0.563964
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.7273% (minimum 95%, Missing); adrenal gland: 65.4545% (minimum 99%, Missing); amygdala: 81.8182% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 80.8989% (minimum 99%, Missing); cerebellum: 72.7273% (minimum 99%, Missing); cerebral cortex: 72.7273% (minimum 99%, Missing); choroid plexus: 73.4694% (minimum 99%, Missing); colon: 75.7895% (minimum 97%, Missing); duodenum: 75.7895% (minimum 99%, Missing); esophagus: 66.0550% (minimum 97%, Missing); heart muscle: 71.2871% (minimum 99%, Missing); hippocampal formation: 78.2609% (minimum 99%, Missing); hypothalamus: 73.4694% (minimum 99%, Missing); kidney: 62.6087% (minimum 99%, Missing); liver: 69.9029% (minimum 99%, Missing); lung: 75.7895% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 76.5957% (minimum 99%, Missing); pancreas: 71.2871% (minimum 99%, Missing); parathyroid gland: 92.3077% (minimum 97%, Missing); pituitary gland: 42.6036% (minimum 99%, Missing); rectum: 83.7209% (minimum 97%, Missing); retina: 80.0000% (minimum 99%, Missing); salivary gland: 72.0000% (minimum 97%, Missing); skeletal muscle: 80.8989% (minimum 99%, Missing); skin: 66.0550% (minimum 95%, Missing); small intestine: 72.7273% (minimum 99%, Missing); smooth muscle: 91.1392% (minimum 99%, Missing); spinal cord: 77.4194% (minimum 99%, Missing); spleen: 67.9245% (minimum 95%, Missing); stomach: 73.4694% (minimum 97%, Missing); thyroid gland: 77.4194% (minimum 95%, Missing); tongue: 87.8049% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,80,unavailable,9.7,3.7,3.7,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 2); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); salivary gland: 2.8 nTPM (protected, limit 2); cerebral cortex: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213588,ZBTB9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.28945,-0.30945,-0.563964
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,11.6,1.3,2.5,"bone marrow: 11.6 nTPM (vital, limit 6)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213714,FAM209B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.5537% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,11.6,1.3,2.5,"bone marrow: 11.6 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213714,FAM209B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.0280123,0.0184444,-0.0844625
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.5537% (minimum 95%, Enhanced)",0,3,partial,11.6,1.3,2.5,"bone marrow: 11.6 nTPM (vital, limit 6)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213714,FAM209B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.0446333,0.0273094,-0.0444625
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,1,partial,43,45.9,34.6,"urinary bladder: 45.9 nTPM (protected, limit 2); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 2); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 2); choroid plexus: 35.1 nTPM (vital, limit 1); thymus: 34.6 nTPM (manageable, limit 5); thyroid gland: 32.3 nTPM (manageable, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 2); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); skin: 29.6 nTPM (manageable, limit 5); stomach: 28.5 nTPM (protected, limit 2); colon: 28.4 nTPM (protected, limit 2); esophagus: 28.3 nTPM (protected, limit 2); adipose tissue: 27.9 nTPM (manageable, limit 10); rectum: 25.5 nTPM (protected, limit 2); lung: 24.1 nTPM (vital, limit 1); salivary gland: 23.7 nTPM (protected, limit 2); adrenal gland: 23.4 nTPM (vital, limit 1); spleen: 22.8 nTPM (manageable, limit 10); heart muscle: 22.3 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000213782,DDX47,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9937% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 60.2716% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.7407% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.0183% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 46.6491% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 62.6102% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.6630% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 50.2833% (minimum 99%, Baseline (adaptation disabled)); colon: 55.5556% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.7293% (minimum 99%, Baseline (adaptation disabled)); esophagus: 55.6426% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 61.4187% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 65.4982% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.7407% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.4639% (minimum 99%, Baseline (adaptation disabled)); liver: 49.1690% (minimum 99%, Baseline (adaptation disabled)); lung: 59.5638% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.6706% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.6630% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.2813% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.1412% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.4905% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.1967% (minimum 97%, Baseline (adaptation disabled)); retina: 68.4008% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.9662% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 45.2229% (minimum 99%, Baseline (adaptation disabled)); skin: 54.5315% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.7208% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 52.4372% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 63.8489% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.8919% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.4688% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.6419% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.3599% (minimum 95%, Baseline (adaptation disabled)); tongue: 47.0199% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 43.6118% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,43,45.9,34.6,"urinary bladder: 45.9 nTPM (protected, limit 2); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 2); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 2); choroid plexus: 35.1 nTPM (vital, limit 1); thymus: 34.6 nTPM (manageable, limit 5); thyroid gland: 32.3 nTPM (manageable, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 2); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); skin: 29.6 nTPM (manageable, limit 5); stomach: 28.5 nTPM (protected, limit 2); colon: 28.4 nTPM (protected, limit 2); esophagus: 28.3 nTPM (protected, limit 2); adipose tissue: 27.9 nTPM (manageable, limit 5); rectum: 25.5 nTPM (protected, limit 2); lung: 24.1 nTPM (vital, limit 1); salivary gland: 23.7 nTPM (protected, limit 2); adrenal gland: 23.4 nTPM (vital, limit 1); spleen: 22.8 nTPM (manageable, limit 5); heart muscle: 22.3 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000213782,DDX47,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.443581,-0.533882,-0.537771
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9937% (minimum 90%, Approved); adrenal gland: 60.2716% (minimum 99%, Missing); amygdala: 65.7407% (minimum 99%, Missing); basal ganglia: 65.0183% (minimum 99%, Missing); bone marrow: 46.6491% (minimum 99%, Missing); cerebellum: 62.6102% (minimum 99%, Missing); cerebral cortex: 64.6630% (minimum 99%, Missing); choroid plexus: 50.2833% (minimum 99%, Missing); colon: 55.5556% (minimum 97%, Missing); duodenum: 66.7293% (minimum 99%, Missing); esophagus: 55.6426% (minimum 97%, Missing); heart muscle: 61.4187% (minimum 99%, Missing); hippocampal formation: 65.4982% (minimum 99%, Missing); hypothalamus: 65.7407% (minimum 99%, Missing); kidney: 53.4639% (minimum 99%, Missing); liver: 49.1690% (minimum 99%, Missing); lung: 59.5638% (minimum 99%, Missing); lymph node: 52.6706% (minimum 97%, Missing); midbrain: 64.6630% (minimum 99%, Missing); pancreas: 54.2813% (minimum 99%, Missing); parathyroid gland: 50.1412% (minimum 97%, Missing); pituitary gland: 67.4905% (minimum 99%, Missing); rectum: 58.1967% (minimum 97%, Missing); retina: 68.4008% (minimum 99%, Missing); salivary gland: 59.9662% (minimum 97%, Missing); skeletal muscle: 45.2229% (minimum 99%, Missing); skin: 54.5315% (minimum 95%, Missing); small intestine: 62.7208% (minimum 99%, Missing); smooth muscle: 52.4372% (minimum 99%, Missing); spinal cord: 63.8489% (minimum 99%, Missing); spleen: 60.8919% (minimum 90%, Approved); stomach: 55.4688% (minimum 97%, Missing); thymus: 50.6419% (minimum 95%, Missing); thyroid gland: 52.3599% (minimum 95%, Missing); tongue: 47.0199% (minimum 97%, Missing); urinary bladder: 43.6118% (minimum 97%, Missing)",0,1,partial,43,45.9,34.6,"urinary bladder: 45.9 nTPM (protected, limit 2); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 2); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 2); choroid plexus: 35.1 nTPM (vital, limit 1); thymus: 34.6 nTPM (manageable, limit 5); thyroid gland: 32.3 nTPM (manageable, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 2); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); skin: 29.6 nTPM (manageable, limit 5); stomach: 28.5 nTPM (protected, limit 2); colon: 28.4 nTPM (protected, limit 2); esophagus: 28.3 nTPM (protected, limit 2); adipose tissue: 27.9 nTPM (manageable, limit 10); rectum: 25.5 nTPM (protected, limit 2); lung: 24.1 nTPM (vital, limit 1); salivary gland: 23.7 nTPM (protected, limit 2); adrenal gland: 23.4 nTPM (vital, limit 1); spleen: 22.8 nTPM (manageable, limit 10); heart muscle: 22.3 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000213782,DDX47,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.443581,-0.533882,-0.537771
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.9,4.2,4.1,"bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213799,ZNF845,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9375% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.6429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.2500% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 81.2500% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 44.3182% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.9091% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.4706% (minimum 99%, Baseline (adaptation disabled)); colon: 58.2090% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.9048% (minimum 99%, Baseline (adaptation disabled)); esophagus: 61.9048% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.1017% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 81.2500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.2500% (minimum 99%, Baseline (adaptation disabled)); kidney: 61.9048% (minimum 99%, Baseline (adaptation disabled)); liver: 72.2222% (minimum 99%, Baseline (adaptation disabled)); lung: 58.2090% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.1481% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.2500% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.1017% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.7027% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 81.2500% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.5217% (minimum 97%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.1017% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 56.5217% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.9375% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 67.2414% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.7027% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.7027% (minimum 97%, Baseline (adaptation disabled)); thymus: 48.7500% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.2414% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.9,4.2,4.1,"bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213799,ZNF845,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4625,-0.488519,-0.546818
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9375% (minimum 95%, Missing); adrenal gland: 69.6429% (minimum 99%, Missing); amygdala: 81.2500% (minimum 99%, Missing); basal ganglia: 81.2500% (minimum 99%, Missing); bone marrow: 44.3182% (minimum 99%, Missing); cerebellum: 70.9091% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); choroid plexus: 76.4706% (minimum 99%, Missing); colon: 58.2090% (minimum 97%, Missing); duodenum: 61.9048% (minimum 99%, Missing); esophagus: 61.9048% (minimum 97%, Missing); heart muscle: 66.1017% (minimum 99%, Missing); hippocampal formation: 81.2500% (minimum 99%, Missing); hypothalamus: 81.2500% (minimum 99%, Missing); kidney: 61.9048% (minimum 99%, Missing); liver: 72.2222% (minimum 99%, Missing); lung: 58.2090% (minimum 99%, Missing); lymph node: 48.1481% (minimum 97%, Missing); midbrain: 81.2500% (minimum 99%, Missing); pancreas: 66.1017% (minimum 99%, Missing); parathyroid gland: 52.7027% (minimum 97%, Missing); pituitary gland: 81.2500% (minimum 99%, Missing); rectum: 56.5217% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); salivary gland: 66.1017% (minimum 97%, Missing); skeletal muscle: 86.6667% (minimum 99%, Missing); skin: 56.5217% (minimum 95%, Missing); small intestine: 60.9375% (minimum 99%, Missing); smooth muscle: 67.2414% (minimum 99%, Missing); spinal cord: 78.0000% (minimum 99%, Missing); spleen: 52.7027% (minimum 95%, Missing); stomach: 52.7027% (minimum 97%, Missing); thymus: 48.7500% (minimum 95%, Missing); thyroid gland: 52.0000% (minimum 95%, Missing); tongue: 67.2414% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",0,80,unavailable,4.9,4.2,4.1,"bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 2); stomach: 3.5 nTPM (protected, limit 2); parathyroid gland: 3.5 nTPM (protected, limit 2); rectum: 3 nTPM (protected, limit 2); lung: 2.8 nTPM (vital, limit 1); colon: 2.8 nTPM (protected, limit 2); urinary bladder: 2.6 nTPM (protected, limit 2); small intestine: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); esophagus: 2.4 nTPM (protected, limit 2); duodenum: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000213799,ZNF845,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.4625,-0.488519,-0.546818
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,6,partial,1.6,0.7,470.5,"skin: 470.5 nTPM (manageable, limit 5); bone marrow: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); spleen / cells in red pulp: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in spinous layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000213927,CCL27,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 94.3262% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.0803% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.8848% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.7941% (minimum 99%, Baseline (adaptation disabled)); retina: 97.0803% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.3405% (minimum 99%, Baseline (adaptation disabled)); skin: 5.3510% (minimum 95%, Baseline (adaptation disabled)); thymus: 85.8065% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,1.6,0.7,470.5,"skin: 470.5 nTPM (manageable, limit 5); bone marrow: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); spleen / cells in red pulp: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in spinous layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000213927,CCL27,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.89649,0.00435897,-0.0467376
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 94.3262% (minimum 99%, Missing); choroid plexus: 97.0803% (minimum 99%, Missing); retina: 97.0803% (minimum 99%, Missing); skin: 5.3510% (minimum 95%, Missing); thymus: 85.8065% (minimum 95%, Missing)",0,6,partial,1.6,0.7,470.5,"skin: 470.5 nTPM (manageable, limit 5); bone marrow: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); spleen / cells in red pulp: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in spinous layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000213927,CCL27,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.89649,0.0188476,-0.0467376
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000214107,MAGEB1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000214107,MAGEB1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000214107,MAGEB1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000214216,IQCJ,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 88.8889% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.8889% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.8889% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 61.5385% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000214216,IQCJ,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,0.03,-0.374615
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 88.8889% (minimum 99%, Missing); cerebral cortex: 88.8889% (minimum 99%, Missing); heart muscle: 88.8889% (minimum 99%, Missing); hippocampal formation: 88.8889% (minimum 99%, Missing); pituitary gland: 61.5385% (minimum 99%, Missing)",0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000214216,IQCJ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,0.03,-0.374615
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,1,partial,2.2,1.5,5.3,"thymus: 5.3 nTPM (manageable, limit 5); liver: 2.2 nTPM (vital, limit 2); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000214226,C17orf67,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3750% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.6087% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.5172% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.3704% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.1667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 67.8571% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.8571% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.0769% (minimum 99%, Baseline (adaptation disabled)); colon: 59.3750% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.0769% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.3704% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 67.8571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 57.5758% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.3704% (minimum 99%, Baseline (adaptation disabled)); liver: 46.3415% (minimum 99%, Baseline (adaptation disabled)); lung: 55.8824% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.8824% (minimum 97%, Baseline (adaptation disabled)); midbrain: 65.5172% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.2857% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 79.1667% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.3750% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.1667% (minimum 97%, Baseline (adaptation disabled)); retina: 70.3704% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 67.8571% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 76.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 79.1667% (minimum 95%, Baseline (adaptation disabled)); small intestine: 54.2857% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 57.5758% (minimum 99%, Baseline (adaptation disabled)); spleen: 42.2222% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.8571% (minimum 97%, Baseline (adaptation disabled)); thymus: 26.3889% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.3750% (minimum 95%, Baseline (adaptation disabled)); tongue: 70.3704% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 57.5758% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,2.2,1.5,5.3,"thymus: 5.3 nTPM (manageable, limit 5); liver: 2.2 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000214226,C17orf67,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.686111,-0.411176,-0.526585
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3750% (minimum 90%, Approved); adrenal gland: 82.6087% (minimum 98%, Approved); amygdala: 65.5172% (minimum 99%, Missing); basal ganglia: 70.3704% (minimum 99%, Missing); bone marrow: 79.1667% (minimum 98%, Approved); cerebellum: 67.8571% (minimum 98%, Approved); cerebral cortex: 67.8571% (minimum 99%, Missing); choroid plexus: 73.0769% (minimum 99%, Missing); colon: 59.3750% (minimum 97%, Missing); duodenum: 73.0769% (minimum 99%, Missing); esophagus: 70.3704% (minimum 97%, Missing); heart muscle: 67.8571% (minimum 98%, Approved); hippocampal formation: 63.3333% (minimum 99%, Missing); hypothalamus: 57.5758% (minimum 99%, Missing); kidney: 70.3704% (minimum 98%, Approved); liver: 46.3415% (minimum 98%, Approved); lung: 55.8824% (minimum 98%, Approved); lymph node: 55.8824% (minimum 95%, Approved); midbrain: 65.5172% (minimum 99%, Missing); pancreas: 54.2857% (minimum 98%, Approved); parathyroid gland: 79.1667% (minimum 95%, Approved); pituitary gland: 59.3750% (minimum 99%, Missing); rectum: 79.1667% (minimum 97%, Missing); retina: 70.3704% (minimum 99%, Missing); salivary gland: 67.8571% (minimum 95%, Approved); skeletal muscle: 76.0000% (minimum 98%, Approved); skin: 79.1667% (minimum 90%, Approved); small intestine: 54.2857% (minimum 99%, Missing); smooth muscle: 63.3333% (minimum 98%, Approved); spinal cord: 57.5758% (minimum 99%, Missing); spleen: 42.2222% (minimum 90%, Approved); stomach: 67.8571% (minimum 97%, Missing); thymus: 26.3889% (minimum 95%, Missing); thyroid gland: 59.3750% (minimum 90%, Approved); tongue: 70.3704% (minimum 97%, Missing); urinary bladder: 57.5758% (minimum 95%, Approved)",0,1,partial,2.2,1.5,5.3,"thymus: 5.3 nTPM (manageable, limit 5); liver: 2.2 nTPM (vital, limit 2); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000214226,C17orf67,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.686111,-0.391176,-0.516585
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2920.4,56.6,36.4,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 2); salivary gland: 51 nTPM (protected, limit 2); rectum: 44.2 nTPM (protected, limit 2); adipose tissue: 36.4 nTPM (manageable, limit 5); colon: 31.5 nTPM (protected, limit 2); pancreas: 29.9 nTPM (vital, limit 1); skin: 26.5 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 2); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 2); esophagus: 9.5 nTPM (protected, limit 2); thyroid gland: 8.5 nTPM (manageable, limit 5); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 2); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000214274,ANG,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6911% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 95.0931% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7411% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.4160% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.2517% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.9094% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.2329% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 70.6918% (minimum 99%, Baseline (adaptation disabled)); colon: 64.0821% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.4104% (minimum 99%, Baseline (adaptation disabled)); esophagus: 85.5403% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 77.5172% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.9324% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.9044% (minimum 99%, Baseline (adaptation disabled)); kidney: 76.0487% (minimum 99%, Baseline (adaptation disabled)); liver: 1.8881% (minimum 99%, Baseline (adaptation disabled)); lung: 75.7412% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.2953% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.0931% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.2729% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.6803% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 92.1311% (minimum 99%, Baseline (adaptation disabled)); rectum: 55.9761% (minimum 97%, Baseline (adaptation disabled)); retina: 96.3979% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 52.4254% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.3537% (minimum 99%, Baseline (adaptation disabled)); skin: 67.9565% (minimum 95%, Baseline (adaptation disabled)); small intestine: 68.1212% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.7662% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.5108% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.6435% (minimum 95%, Baseline (adaptation disabled)); stomach: 49.8227% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 86.8624% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.7662% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 70.0748% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2920.4,56.6,36.4,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 2); salivary gland: 51 nTPM (protected, limit 2); rectum: 44.2 nTPM (protected, limit 2); adipose tissue: 36.4 nTPM (manageable, limit 5); colon: 31.5 nTPM (protected, limit 2); pancreas: 29.9 nTPM (vital, limit 1); skin: 26.5 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 2); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 2); esophagus: 9.5 nTPM (protected, limit 2); thyroid gland: 8.5 nTPM (manageable, limit 5); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 2); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000214274,ANG,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.343089,-0.471773,-0.971119
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6911% (minimum 95%, Missing); adrenal gland: 95.0931% (minimum 99%, Missing); amygdala: 95.7411% (minimum 99%, Missing); basal ganglia: 95.4160% (minimum 99%, Missing); bone marrow: 98.2517% (minimum 99%, Missing); cerebellum: 97.9094% (minimum 99%, Missing); cerebral cortex: 96.2329% (minimum 99%, Missing); choroid plexus: 70.6918% (minimum 99%, Missing); colon: 64.0821% (minimum 97%, Missing); duodenum: 71.4104% (minimum 99%, Missing); esophagus: 85.5403% (minimum 97%, Missing); heart muscle: 77.5172% (minimum 99%, Missing); hippocampal formation: 94.9324% (minimum 99%, Missing); hypothalamus: 95.9044% (minimum 99%, Missing); kidney: 76.0487% (minimum 99%, Missing); liver: 1.8881% (minimum 99%, Missing); lung: 75.7412% (minimum 99%, Missing); lymph node: 94.2953% (minimum 97%, Missing); midbrain: 95.0931% (minimum 99%, Missing); pancreas: 65.2729% (minimum 99%, Missing); parathyroid gland: 91.6803% (minimum 97%, Missing); pituitary gland: 92.1311% (minimum 99%, Missing); rectum: 55.9761% (minimum 97%, Missing); retina: 96.3979% (minimum 99%, Missing); salivary gland: 52.4254% (minimum 97%, Missing); skeletal muscle: 90.3537% (minimum 99%, Missing); skin: 67.9565% (minimum 95%, Missing); small intestine: 68.1212% (minimum 99%, Missing); smooth muscle: 84.7662% (minimum 99%, Missing); spinal cord: 93.5108% (minimum 99%, Missing); spleen: 88.6435% (minimum 95%, Missing); stomach: 49.8227% (minimum 97%, Missing); thyroid gland: 86.8624% (minimum 95%, Missing); tongue: 84.7662% (minimum 97%, Missing); urinary bladder: 70.0748% (minimum 97%, Missing)",0,80,unavailable,2920.4,56.6,36.4,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 2); salivary gland: 51 nTPM (protected, limit 2); rectum: 44.2 nTPM (protected, limit 2); adipose tissue: 36.4 nTPM (manageable, limit 5); colon: 31.5 nTPM (protected, limit 2); pancreas: 29.9 nTPM (vital, limit 1); skin: 26.5 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 2); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 2); esophagus: 9.5 nTPM (protected, limit 2); thyroid gland: 8.5 nTPM (manageable, limit 5); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 2); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 2); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000214274,ANG,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.343089,-0.471773,-0.971119
True,compatible,,True,True,False,,0,3,partial,0.1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000214300,SPDYE3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 96.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.0000% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000214300,SPDYE3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.01,-0.01,-0.03
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.0000% (minimum 97%, Supported); cerebellum: 96.0000% (minimum 97%, Supported); kidney: 96.0000% (minimum 97%, Supported); liver: 96.0000% (minimum 97%, Supported); pituitary gland: 96.0000% (minimum 99%, Missing)",0,3,partial,0.1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,ENSG00000214300,SPDYE3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.05,0.03,-0.03
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000214324,PRR23E,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000214324,PRR23E,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000214324,PRR23E,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8,2.2,1,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000214338,MTCL3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 42.3077% (minimum 99%, Baseline (adaptation disabled)); amygdala: 64.7059% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.5714% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 78.5714% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 12.0879% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 73.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 64.7059% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.7059% (minimum 99%, Baseline (adaptation disabled)); esophagus: 47.8261% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 78.5714% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.1111% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.1111% (minimum 99%, Baseline (adaptation disabled)); kidney: 84.6154% (minimum 99%, Baseline (adaptation disabled)); liver: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 32.3529% (minimum 99%, Baseline (adaptation disabled)); lymph node: 68.7500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 37.9310% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.0000% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 36.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.7059% (minimum 97%, Baseline (adaptation disabled)); retina: 25.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.7500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.5714% (minimum 99%, Baseline (adaptation disabled)); skin: 64.7059% (minimum 95%, Baseline (adaptation disabled)); small intestine: 47.8261% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.5714% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 23.4043% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.3810% (minimum 95%, Baseline (adaptation disabled)); stomach: 33.3333% (minimum 97%, Baseline (adaptation disabled)); thymus: 91.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.6154% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.7059% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8,2.2,1,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000214338,MTCL3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.42619,-0.636667,-0.869121
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 73.3333% (minimum 95%, Missing); adrenal gland: 42.3077% (minimum 99%, Missing); amygdala: 64.7059% (minimum 99%, Missing); basal ganglia: 78.5714% (minimum 99%, Missing); bone marrow: 78.5714% (minimum 99%, Missing); cerebellum: 73.3333% (minimum 99%, Missing); cerebral cortex: 12.0879% (minimum 99%, Missing); choroid plexus: 73.3333% (minimum 99%, Missing); colon: 64.7059% (minimum 97%, Missing); duodenum: 64.7059% (minimum 99%, Missing); esophagus: 47.8261% (minimum 97%, Missing); heart muscle: 78.5714% (minimum 99%, Missing); hippocampal formation: 61.1111% (minimum 99%, Missing); hypothalamus: 61.1111% (minimum 99%, Missing); kidney: 84.6154% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 32.3529% (minimum 99%, Missing); lymph node: 68.7500% (minimum 97%, Missing); midbrain: 37.9310% (minimum 99%, Missing); pancreas: 55.0000% (minimum 99%, Missing); pituitary gland: 36.6667% (minimum 99%, Missing); rectum: 64.7059% (minimum 97%, Missing); retina: 25.0000% (minimum 99%, Missing); salivary gland: 68.7500% (minimum 97%, Missing); skeletal muscle: 78.5714% (minimum 99%, Missing); skin: 64.7059% (minimum 95%, Missing); small intestine: 47.8261% (minimum 99%, Missing); smooth muscle: 78.5714% (minimum 99%, Missing); spinal cord: 23.4043% (minimum 99%, Missing); spleen: 52.3810% (minimum 95%, Missing); stomach: 33.3333% (minimum 97%, Missing); thymus: 91.6667% (minimum 95%, Missing); thyroid gland: 55.0000% (minimum 95%, Missing); tongue: 84.6154% (minimum 97%, Missing); urinary bladder: 64.7059% (minimum 97%, Missing)",0,80,unavailable,8,2.2,1,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); stomach: 2.2 nTPM (protected, limit 2); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000214338,MTCL3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.42619,-0.636667,-0.869121
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000214360,EFCAB9,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 97.9798% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000214360,EFCAB9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.010202
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 97.9798% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000214360,EFCAB9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.010202
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,10,partial,1.7,0,0.2,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),70,not_established,not_triggered,,,ENSG00000214415,GNAT3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 60.0000% (minimum 95%, Baseline (adaptation disabled)); duodenum: 15.0000% (minimum 99%, Baseline (adaptation disabled)); small intestine: 20.0000% (minimum 99%, Baseline (adaptation disabled))",0,10,partial,1.7,0,0.2,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),70,not_established,not_triggered,,,ENSG00000214415,GNAT3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.35,0.03,-0.84
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"duodenum: 15.0000% (minimum 99%, Missing); small intestine: 20.0000% (minimum 99%, Missing)",0,10,partial,1.7,0,0.2,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),70,not_established,not_triggered,,,ENSG00000214415,GNAT3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0,0.03,-0.84
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.8,0.4,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000214511,HIGD1C,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adipose tissue: 50.0000% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); liver: 33.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); pancreas: 27.2727% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 50.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 75.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 60.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 42.8571% (minimum 99%, Baseline (adaptation disabled)); skin: 42.8571% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 42.8571% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 42.8571% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.4,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000214511,HIGD1C,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.521429,-0.541429,-0.717273
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adipose tissue: 50.0000% (minimum 95%, Missing); bone marrow: 75.0000% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); liver: 33.3333% (minimum 99%, Missing); lung: 60.0000% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); pancreas: 27.2727% (minimum 99%, Missing); parathyroid gland: 50.0000% (minimum 97%, Missing); pituitary gland: 75.0000% (minimum 99%, Missing); rectum: 75.0000% (minimum 97%, Missing); retina: 60.0000% (minimum 99%, Missing); salivary gland: 60.0000% (minimum 97%, Missing); skeletal muscle: 42.8571% (minimum 99%, Missing); skin: 42.8571% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 60.0000% (minimum 99%, Missing); spleen: 60.0000% (minimum 95%, Missing); stomach: 42.8571% (minimum 97%, Missing); thyroid gland: 42.8571% (minimum 95%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",0,80,unavailable,0.8,0.4,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000214511,HIGD1C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.521429,-0.541429,-0.717273
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000214681,IQCF5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000214681,IQCF5,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000214681,IQCF5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,ENSG00000214686,IQCF6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 98.5849% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,ENSG00000214686,IQCF6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.0252381,-0.00415094
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 98.5849% (minimum 99%, Missing)",0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,ENSG00000214686,IQCF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.0252381,-0.00415094
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,False,,0,3,partial,18.1,0.2,0,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),53,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000214782,MS4A18,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"duodenum: 24.2678% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 98.3051% (minimum 99%, Baseline (adaptation disabled)); small intestine: 65.9091% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,18.1,0.2,0,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),53,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000214782,MS4A18,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.00333333,-0.747322
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"duodenum: 24.2678% (minimum 99%, Missing); retina: 98.3051% (minimum 99%, Missing); small intestine: 65.9091% (minimum 99%, Missing)",0,3,partial,18.1,0.2,0,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),53,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000214782,MS4A18,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.0166667,-0.747322
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,9,partial,4.4,42,2.2,"stomach: 42 nTPM (protected, limit 2); rectum: 10.4 nTPM (protected, limit 2); colon: 4.9 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),70,not_established,required,in_situ_inflammation_review,appendix; appendix / goblet cells,ENSG00000214814,FER1L6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 96.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 32.8767% (minimum 97%, Baseline (adaptation disabled)); duodenum: 46.1538% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 43.6364% (minimum 99%, Baseline (adaptation disabled)); lung: 96.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 18.7500% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.0000% (minimum 99%, Baseline (adaptation disabled)); small intestine: 35.2941% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.0000% (minimum 99%, Baseline (adaptation disabled)); stomach: 5.4054% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 52.1739% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.0000% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,4.4,42,2.2,"stomach: 42 nTPM (protected, limit 2); rectum: 10.4 nTPM (protected, limit 2); colon: 4.9 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),70,not_established,required,in_situ_inflammation_review,appendix; appendix / goblet cells,ENSG00000214814,FER1L6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.428261,-0.915946,-0.637059
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 32.8767% (minimum 97%, Missing); duodenum: 46.1538% (minimum 99%, Missing); kidney: 43.6364% (minimum 95%, Enhanced); rectum: 18.7500% (minimum 97%, Missing); skeletal muscle: 96.0000% (minimum 99%, Missing); small intestine: 35.2941% (minimum 99%, Missing); stomach: 5.4054% (minimum 97%, Missing); thyroid gland: 52.1739% (minimum 95%, Missing)",0,9,partial,4.4,42,2.2,"stomach: 42 nTPM (protected, limit 2); rectum: 10.4 nTPM (protected, limit 2); colon: 4.9 nTPM (protected, limit 2); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),70,not_established,required,in_situ_inflammation_review,appendix; appendix / goblet cells,ENSG00000214814,FER1L6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.428261,-0.915946,-0.637059
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.2,0.1,0,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,ENSG00000214819,CDRT15L2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hippocampal formation: 87.2832% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.2,0.1,0,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,ENSG00000214819,CDRT15L2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.0234211,-0.117168
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hippocampal formation: 87.2832% (minimum 99%, Missing)",0,80,unavailable,2.2,0.1,0,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,ENSG00000214819,CDRT15L2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.0234211,-0.117168
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000214842,RAD51AP2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.9130% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.8495% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.8085% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.8495% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.9130% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9130% (minimum 99%, Baseline (adaptation disabled)); liver: 97.8495% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.8495% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000214842,RAD51AP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0391304,0.00849462,-0.0219149
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.9130% (minimum 99%, Missing); cerebellum: 97.8495% (minimum 99%, Missing); cerebral cortex: 96.8085% (minimum 99%, Missing); heart muscle: 97.8495% (minimum 99%, Missing); hippocampal formation: 98.9130% (minimum 99%, Missing); hypothalamus: 98.9130% (minimum 99%, Missing); liver: 97.8495% (minimum 99%, Missing); pancreas: 97.8495% (minimum 99%, Missing)",0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000214842,RAD51AP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0391304,0.00849462,-0.0219149
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.2,0.1,0.2,"choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,ENSG00000214866,DCDC2C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.9091% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.9231% (minimum 99%, Baseline (adaptation disabled)); lung: 97.5610% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.5610% (minimum 99%, Baseline (adaptation disabled)); retina: 93.0233% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.2381% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.2,0.1,0.2,"choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,ENSG00000214866,DCDC2C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,0.00238095,0.00560976,-0.220769
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 90.9091% (minimum 99%, Missing); choroid plexus: 76.9231% (minimum 99%, Missing); lung: 97.5610% (minimum 99%, Missing); pituitary gland: 97.5610% (minimum 99%, Missing); retina: 93.0233% (minimum 99%, Missing); skeletal muscle: 95.2381% (minimum 99%, Missing)",0,80,unavailable,1.2,0.1,0.2,"choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,ENSG00000214866,DCDC2C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,0.00238095,0.00560976,-0.220769
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000214897,PNMA6E,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 98.3051% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.4790% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000214897,PNMA6E,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.041453,0.03,-0.0152101
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 98.3051% (minimum 99%, Missing); pituitary gland: 97.4790% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000214897,PNMA6E,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.041453,0.03,-0.0152101
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000214929,SPATA31D1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000214929,SPATA31D1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000214929,SPATA31D1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.2,0.1,0.1,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000214946,TBC1D26,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 89.0173% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 78.5714% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7179% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.7711% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.6957% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.4684% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.4684% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.7179% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.4684% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,4.2,0.1,0.1,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000214946,TBC1D26,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0435484,0.0235484,-0.204286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 89.0173% (minimum 99%, Missing); basal ganglia: 78.5714% (minimum 99%, Missing); cerebellum: 98.7179% (minimum 99%, Missing); cerebral cortex: 92.7711% (minimum 99%, Missing); hippocampal formation: 83.6957% (minimum 99%, Missing); hypothalamus: 97.4684% (minimum 99%, Missing); midbrain: 97.4684% (minimum 99%, Missing); pituitary gland: 98.7179% (minimum 99%, Missing); spinal cord: 97.4684% (minimum 99%, Missing)",0,80,unavailable,4.2,0.1,0.1,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000214946,TBC1D26,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0435484,0.0235484,-0.204286
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.4,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen,ENSG00000215009,ACSM4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 88.8889% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 88.8889% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.8889% (minimum 99%, Baseline (adaptation disabled)); duodenum: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); small intestine: 72.7273% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.5385% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen,ENSG00000215009,ACSM4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.334615,-0.0811111,-0.323333
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 88.8889% (minimum 95%, Missing); adrenal gland: 88.8889% (minimum 99%, Missing); cerebral cortex: 88.8889% (minimum 99%, Missing); duodenum: 80.0000% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); small intestine: 72.7273% (minimum 99%, Missing); spleen: 61.5385% (minimum 95%, Missing)",0,80,unavailable,0.4,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen,ENSG00000215009,ACSM4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.334615,-0.0811111,-0.323333
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215113,CXorf49B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215113,CXorf49B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215113,CXorf49B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215115,CXorf49,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215115,CXorf49,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215115,CXorf49,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,7,partial,7.1,2.8,2.1,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 2); spinal cord: 2.1 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000215126,ZNG1F,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8140% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 32.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 53.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.5385% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.1739% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.5714% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.5366% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 85.7143% (minimum 99%, Baseline (adaptation disabled)); colon: 57.1429% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 46.1538% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 42.8571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 66.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.8140% (minimum 99%, Baseline (adaptation disabled)); kidney: 42.1053% (minimum 99%, Baseline (adaptation disabled)); liver: 25.2632% (minimum 99%, Baseline (adaptation disabled)); lung: 55.8140% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8889% (minimum 97%, Baseline (adaptation disabled)); midbrain: 54.5455% (minimum 99%, Baseline (adaptation disabled)); pancreas: 42.1053% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.3077% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 48.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 88.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 58.5366% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 40.6780% (minimum 99%, Baseline (adaptation disabled)); skin: 63.1579% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.1429% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.7586% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.5455% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.1739% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.8889% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 53.3333% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 68.5714% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,7.1,2.8,2.1,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000215126,ZNG1F,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.416667,-0.508462,-0.737368
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8140% (minimum 90%, Approved); adrenal gland: 32.0000% (minimum 99%, Missing); amygdala: 53.3333% (minimum 99%, Missing); basal ganglia: 61.5385% (minimum 99%, Missing); bone marrow: 52.1739% (minimum 98%, Approved); cerebellum: 68.5714% (minimum 99%, Missing); cerebral cortex: 58.5366% (minimum 99%, Missing); choroid plexus: 85.7143% (minimum 99%, Missing); colon: 57.1429% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 46.1538% (minimum 97%, Missing); heart muscle: 42.8571% (minimum 99%, Missing); hippocampal formation: 66.6667% (minimum 99%, Missing); hypothalamus: 55.8140% (minimum 99%, Missing); kidney: 42.1053% (minimum 99%, Missing); liver: 25.2632% (minimum 99%, Missing); lung: 55.8140% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); midbrain: 54.5455% (minimum 99%, Missing); pancreas: 42.1053% (minimum 99%, Missing); parathyroid gland: 92.3077% (minimum 97%, Missing); pituitary gland: 48.0000% (minimum 99%, Missing); rectum: 88.8889% (minimum 97%, Missing); retina: 58.5366% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing); skeletal muscle: 40.6780% (minimum 98%, Approved); skin: 63.1579% (minimum 95%, Missing); small intestine: 57.1429% (minimum 99%, Missing); smooth muscle: 82.7586% (minimum 98%, Approved); spinal cord: 53.3333% (minimum 99%, Missing); spleen: 54.5455% (minimum 95%, Missing); stomach: 52.1739% (minimum 97%, Missing); thymus: 88.8889% (minimum 95%, Missing); thyroid gland: 53.3333% (minimum 95%, Missing); urinary bladder: 68.5714% (minimum 97%, Missing)",0,7,partial,7.1,2.8,2.1,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); esophagus: 2.8 nTPM (protected, limit 2); pituitary gland: 2.6 nTPM (vital, limit 1); salivary gland: 2.4 nTPM (protected, limit 2); stomach: 2.2 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 2); spinal cord: 2.1 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000215126,ZNG1F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.416667,-0.508462,-0.737368
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215131,C16orf90,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215131,C16orf90,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00787686
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215131,C16orf90,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00787686
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.4,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000215148,PRSS41,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 92.3077% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); stomach: 80.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.4,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000215148,PRSS41,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.22,-0.0669231
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 92.3077% (minimum 99%, Missing); salivary gland: 75.0000% (minimum 97%, Missing); stomach: 80.0000% (minimum 97%, Missing)",0,80,unavailable,0.1,0.4,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000215148,PRSS41,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.22,-0.0669231
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,1,partial,4.2,0,0.2,"liver: 4.2 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000215186,GOLGA6B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 98.5915% (minimum 99%, Baseline (adaptation disabled)); liver: 62.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 94.5946% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.8904% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,4.2,0,0.2,"liver: 4.2 nTPM (vital, limit 1)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000215186,GOLGA6B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0222222,0.03,-0.365
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 62.5000% (minimum 97%, Supported); retina: 94.5946% (minimum 99%, Missing); skeletal muscle: 95.8904% (minimum 97%, Supported)",0,1,partial,4.2,0,0.2,"liver: 4.2 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000215186,GOLGA6B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.05,0.03,-0.345
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000215203,GRXCR1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"thymus: 88.8889% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000215203,GRXCR1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.0611111,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"thymus: 88.8889% (minimum 95%, Missing)",0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000215203,GRXCR1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.0611111,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215262,KCNU1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.5507% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215262,KCNU1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00449275
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 98.5507% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215262,KCNU1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.00449275
True,compatible,,True,True,False,,0,4,partial,1,5.9,0,,,52,not_established,not_triggered,,,ENSG00000215269,GAGE12G,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.3633% (minimum 99%, Baseline (adaptation disabled)); stomach: 91.0606% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,1,5.9,0,"stomach: 5.9 nTPM (protected, limit 2)",,52,not_established,not_triggered,,,ENSG00000215269,GAGE12G,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,-0.0593939,-0.00636661
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.3633% (minimum 99%, Missing)",0,4,partial,1,5.9,0,,,52,not_established,not_triggered,,,ENSG00000215269,GAGE12G,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.0106061,-0.00636661
True,compatible,,True,True,False,,0,4,partial,0.8,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000215274,GAGE10,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0,Seager 2024,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 88.8889% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 76.1905% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 88.8889% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.1176% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.2105% (minimum 99%, Baseline (adaptation disabled)); colon: 94.1176% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.1176% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.1176% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.1176% (minimum 97%, Baseline (adaptation disabled)); midbrain: 94.1176% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.1176% (minimum 97%, Baseline (adaptation disabled)); retina: 76.1905% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.1176% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.1176% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.1176% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 88.8889% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.1176% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,0.8,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000215274,GAGE10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0,Seager 2024,-0.0611111,-0.0288235,-0.323333
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 88.8889% (minimum 99%, Missing); basal ganglia: 76.1905% (minimum 99%, Missing); cerebellum: 88.8889% (minimum 97%, Supported); cerebral cortex: 94.1176% (minimum 97%, Supported); choroid plexus: 84.2105% (minimum 99%, Missing); colon: 94.1176% (minimum 97%, Missing); heart muscle: 94.1176% (minimum 97%, Supported); hippocampal formation: 94.1176% (minimum 99%, Missing); hypothalamus: 94.1176% (minimum 99%, Missing); midbrain: 94.1176% (minimum 99%, Missing); pituitary gland: 66.6667% (minimum 99%, Missing); retina: 76.1905% (minimum 99%, Missing); skeletal muscle: 94.1176% (minimum 97%, Supported); small intestine: 94.1176% (minimum 97%, Supported); smooth muscle: 88.8889% (minimum 97%, Supported); spinal cord: 94.1176% (minimum 99%, Missing)",0,4,partial,0.8,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000215274,GAGE10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0,Seager 2024,0.05,-0.0288235,-0.323333
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,25,0.2,0.4,"kidney: 25 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,ENSG00000215277,RNF212B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 98.1132% (minimum 99%, Baseline (adaptation disabled)); kidney: 17.2185% (minimum 99%, Baseline (adaptation disabled)); liver: 98.1132% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.2963% (minimum 97%, Baseline (adaptation disabled)); retina: 92.8571% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.1132% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.2963% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 92.8571% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,25,0.2,0.4,"kidney: 25 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,ENSG00000215277,RNF212B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,-0.0214286,-0.00703704,-0.817815
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 98.1132% (minimum 99%, Missing); kidney: 17.2185% (minimum 99%, Missing); liver: 98.1132% (minimum 99%, Missing); lymph node: 96.2963% (minimum 97%, Missing); retina: 92.8571% (minimum 99%, Missing); small intestine: 98.1132% (minimum 99%, Missing); stomach: 96.2963% (minimum 97%, Missing); thyroid gland: 92.8571% (minimum 95%, Missing)",0,80,unavailable,25,0.2,0.4,"kidney: 25 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,ENSG00000215277,RNF212B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019;da Silva 2017,-0.0214286,-0.00703704,-0.817815
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215343,ZNF705D,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215343,ZNF705D,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215343,ZNF705D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215356,ZNF705B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215356,ZNF705B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000215356,ZNF705B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215372,ZNF705G,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"retina: 85.7143% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215372,ZNF705G,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.132857
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"retina: 85.7143% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215372,ZNF705G,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.132857
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,5.1,3.6,5,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000215421,ZNF407,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.4068% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.8571% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.5510% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.5098% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 42.6966% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.4068% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 58.4615% (minimum 97%, Baseline (adaptation disabled)); duodenum: 65.5172% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.2951% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 55.8824% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 77.5510% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.1667% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 64.4068% (minimum 99%, Baseline (adaptation disabled)); lung: 63.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 55.0725% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.1667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.5172% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.3514% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.6981% (minimum 99%, Baseline (adaptation disabled)); rectum: 64.4068% (minimum 97%, Baseline (adaptation disabled)); retina: 58.4615% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 50.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 63.3333% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.7164% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 74.5098% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.2857% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.4068% (minimum 97%, Baseline (adaptation disabled)); thymus: 43.1818% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.7778% (minimum 95%, Baseline (adaptation disabled)); tongue: 54.2857% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.2951% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,5.1,3.6,5,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000215421,ZNF407,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.518182,-0.456486,-0.563034
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.4068% (minimum 95%, Uncertain); adrenal gland: 67.8571% (minimum 99%, Missing); amygdala: 77.5510% (minimum 99%, Missing); basal ganglia: 74.5098% (minimum 99%, Missing); bone marrow: 42.6966% (minimum 99%, Missing); cerebellum: 64.4068% (minimum 99%, Missing); cerebral cortex: 63.3333% (minimum 99%, Missing); choroid plexus: 76.0000% (minimum 99%, Missing); colon: 58.4615% (minimum 97%, Missing); duodenum: 65.5172% (minimum 99%, Missing); esophagus: 62.2951% (minimum 97%, Missing); heart muscle: 55.8824% (minimum 99%, Missing); hippocampal formation: 77.5510% (minimum 99%, Missing); hypothalamus: 79.1667% (minimum 99%, Missing); kidney: 63.3333% (minimum 99%, Missing); liver: 64.4068% (minimum 99%, Missing); lung: 63.3333% (minimum 99%, Missing); lymph node: 55.0725% (minimum 97%, Missing); midbrain: 79.1667% (minimum 99%, Missing); pancreas: 65.5172% (minimum 99%, Missing); parathyroid gland: 51.3514% (minimum 97%, Missing); pituitary gland: 71.6981% (minimum 99%, Missing); rectum: 64.4068% (minimum 97%, Missing); retina: 58.4615% (minimum 99%, Missing); salivary gland: 63.3333% (minimum 97%, Missing); skeletal muscle: 50.0000% (minimum 99%, Missing); skin: 63.3333% (minimum 95%, Missing); small intestine: 63.3333% (minimum 99%, Missing); smooth muscle: 56.7164% (minimum 99%, Missing); spinal cord: 74.5098% (minimum 99%, Missing); spleen: 54.2857% (minimum 95%, Missing); stomach: 64.4068% (minimum 97%, Missing); thymus: 43.1818% (minimum 95%, Missing); thyroid gland: 52.7778% (minimum 95%, Missing); tongue: 54.2857% (minimum 97%, Missing); urinary bladder: 62.2951% (minimum 97%, Missing)",0,5,partial,5.1,3.6,5,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 2); tongue: 3.2 nTPM (protected, limit 2); lymph node: 3.1 nTPM (protected, limit 2); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); colon: 2.7 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); esophagus: 2.3 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); salivary gland: 2.2 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); cerebellum: 2.1 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000215421,ZNF407,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.518182,-0.456486,-0.563034
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,10.1,"skin: 10.1 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000215455,KRTAP10-1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,10.1,"skin: 10.1 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000215455,KRTAP10-1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,10.1,"skin: 10.1 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000215455,KRTAP10-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000215474,SKOR2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"cerebellum: 70.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 77.7778% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.5000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000215474,SKOR2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.29
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"cerebellum: 70.0000% (minimum 99%, Missing); hypothalamus: 87.5000% (minimum 99%, Missing); retina: 77.7778% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000215474,SKOR2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.29
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000215529,EFCAB8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.0588% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.0588% (minimum 99%, Baseline (adaptation disabled)); liver: 97.0588% (minimum 99%, Baseline (adaptation disabled)); lung: 97.0588% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.0588% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.6667% (minimum 99%, Baseline (adaptation disabled)); small intestine: 91.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.2857% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000215529,EFCAB8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,-0.0333333,0.000588235,-0.0733333
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.0588% (minimum 99%, Missing); choroid plexus: 97.0588% (minimum 99%, Missing); liver: 97.0588% (minimum 99%, Missing); lung: 97.0588% (minimum 99%, Missing); pancreas: 97.0588% (minimum 99%, Missing); pituitary gland: 91.6667% (minimum 99%, Missing); small intestine: 91.6667% (minimum 99%, Missing); spleen: 91.6667% (minimum 95%, Missing); thyroid gland: 94.2857% (minimum 95%, Missing)",0,80,unavailable,0.3,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,ENSG00000215529,EFCAB8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,-0.0333333,0.000588235,-0.0733333
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215568,GAB4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"spinal cord: 95.2381% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215568,GAB4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.037619
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"spinal cord: 95.2381% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000215568,GAB4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.037619
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000215817,ZC3H11B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 96.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.9592% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.9592% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.9592% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.9592% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.9592% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 96.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 97.9592% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.9592% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.9592% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.9592% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000215817,ZC3H11B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.01,-0.01,-0.0488235
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 96.0000% (minimum 99%, Missing); amygdala: 97.9592% (minimum 99%, Missing); basal ganglia: 97.9592% (minimum 99%, Missing); cerebellum: 96.0000% (minimum 99%, Missing); cerebral cortex: 97.9592% (minimum 99%, Missing); heart muscle: 94.1176% (minimum 99%, Missing); hippocampal formation: 97.9592% (minimum 99%, Missing); hypothalamus: 97.9592% (minimum 99%, Missing); kidney: 96.0000% (minimum 99%, Missing); liver: 96.0000% (minimum 99%, Missing); lung: 97.9592% (minimum 99%, Missing); midbrain: 97.9592% (minimum 99%, Missing); pancreas: 97.9592% (minimum 99%, Missing); pituitary gland: 96.0000% (minimum 99%, Missing); salivary gland: 96.0000% (minimum 97%, Missing); skeletal muscle: 94.1176% (minimum 99%, Missing); small intestine: 96.0000% (minimum 99%, Missing); spinal cord: 97.9592% (minimum 99%, Missing)",0,80,unavailable,0.3,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,ENSG00000215817,ZC3H11B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.01,-0.01,-0.0488235
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,7,partial,4.3,3.1,3.2,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); stomach: 3 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000215883,CYB5RL,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 41.0959% (minimum 99%, Baseline (adaptation disabled)); amygdala: 61.2245% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 58.8235% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.2245% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.8235% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.8235% (minimum 99%, Baseline (adaptation disabled)); colon: 57.6923% (minimum 97%, Baseline (adaptation disabled)); duodenum: 55.5556% (minimum 99%, Baseline (adaptation disabled)); esophagus: 61.2245% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 52.6316% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.8235% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.2174% (minimum 99%, Baseline (adaptation disabled)); kidney: 55.5556% (minimum 99%, Baseline (adaptation disabled)); liver: 50.8475% (minimum 99%, Baseline (adaptation disabled)); lung: 63.8298% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.6038% (minimum 97%, Baseline (adaptation disabled)); midbrain: 60.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 42.2535% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.1803% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 45.4545% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.6038% (minimum 97%, Baseline (adaptation disabled)); retina: 54.5455% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.5714% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 43.4783% (minimum 99%, Baseline (adaptation disabled)); skin: 48.3871% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 60.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.1818% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.5556% (minimum 95%, Baseline (adaptation disabled)); tongue: 52.6316% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 61.2245% (minimum 97%, Baseline (adaptation disabled))",0,7,partial,4.3,3.1,3.2,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); stomach: 3 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000215883,CYB5RL,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.466129,-0.478197,-0.579041
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0000% (minimum 90%, Approved); adrenal gland: 41.0959% (minimum 99%, Missing); amygdala: 61.2245% (minimum 99%, Missing); basal ganglia: 62.5000% (minimum 99%, Missing); bone marrow: 58.8235% (minimum 99%, Missing); cerebellum: 61.2245% (minimum 99%, Missing); cerebral cortex: 58.8235% (minimum 99%, Missing); choroid plexus: 58.8235% (minimum 99%, Missing); colon: 57.6923% (minimum 97%, Missing); duodenum: 55.5556% (minimum 99%, Missing); esophagus: 61.2245% (minimum 97%, Missing); heart muscle: 52.6316% (minimum 99%, Missing); hippocampal formation: 58.8235% (minimum 99%, Missing); hypothalamus: 65.2174% (minimum 99%, Missing); kidney: 55.5556% (minimum 99%, Missing); liver: 50.8475% (minimum 99%, Missing); lung: 63.8298% (minimum 99%, Missing); lymph node: 56.6038% (minimum 97%, Missing); midbrain: 60.0000% (minimum 99%, Missing); pancreas: 42.2535% (minimum 99%, Missing); parathyroid gland: 49.1803% (minimum 97%, Missing); pituitary gland: 45.4545% (minimum 99%, Missing); rectum: 56.6038% (minimum 97%, Missing); retina: 54.5455% (minimum 99%, Missing); salivary gland: 53.5714% (minimum 97%, Missing); skeletal muscle: 43.4783% (minimum 99%, Missing); skin: 48.3871% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 60.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 90%, Approved); stomach: 50.0000% (minimum 97%, Missing); thymus: 68.1818% (minimum 95%, Missing); thyroid gland: 55.5556% (minimum 95%, Missing); tongue: 52.6316% (minimum 97%, Missing); urinary bladder: 61.2245% (minimum 97%, Missing)",0,7,partial,4.3,3.1,3.2,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 2); stomach: 3 nTPM (protected, limit 2); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); tongue: 2.7 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); retina: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); lymph node: 2.3 nTPM (protected, limit 2); rectum: 2.3 nTPM (protected, limit 2); colon: 2.2 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000215883,CYB5RL,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.466129,-0.478197,-0.579041
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,3.8,0,0,"retina: 3.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000215906,LACTBL1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"retina: 5.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.8,0,0,"retina: 3.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000215906,LACTBL1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.94
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"retina: 5.0000% (minimum 99%, Missing)",0,80,unavailable,3.8,0,0,"retina: 3.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000215906,LACTBL1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.94
True,compatible,,True,True,False,,0,6,partial,0.5,0.1,0.3,,,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / hair follicles; spleen,ENSG00000215910,C1orf167,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 98.5612% (minimum 99%, Baseline (adaptation disabled)); lung: 98.2079% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.2079% (minimum 99%, Baseline (adaptation disabled))",0,6,partial,0.5,0.1,0.3,,,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / hair follicles; spleen,ENSG00000215910,C1orf167,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0391697,0.0263636,-0.00792115
True,compatible,,True,True,True,,0,6,partial,0.5,0.1,0.3,,,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / hair follicles; spleen,ENSG00000215910,C1orf167,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0463636,0.0263636,0.00636364
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000216649,GAGE12E,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000216649,GAGE12E,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000216649,GAGE12E,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.6,1.5,1.6,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000216937,CCDC7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41388-018-0357-2,Chang 2019;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8432% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.8372% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.8432% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.7163% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.8432% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2120% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.5897% (minimum 99%, Baseline (adaptation disabled)); retina: 96.7296% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9704% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5897% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.6,1.5,1.6,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000216937,CCDC7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41388-018-0357-2,Chang 2019;Bruggeman 2018,0.0296178,0.0108673,-0.0227044
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8432% (minimum 99%, Missing); bone marrow: 97.8372% (minimum 99%, Missing); duodenum: 98.8432% (minimum 99%, Missing); heart muscle: 98.7163% (minimum 99%, Missing); kidney: 98.8432% (minimum 99%, Missing); pancreas: 98.2120% (minimum 99%, Missing); pituitary gland: 98.5897% (minimum 99%, Missing); retina: 96.7296% (minimum 99%, Missing); small intestine: 98.9704% (minimum 99%, Missing); smooth muscle: 98.5897% (minimum 99%, Missing)",0,80,unavailable,2.6,1.5,1.6,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000216937,CCDC7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41388-018-0357-2,Chang 2019;Bruggeman 2018,0.0296178,0.0108673,-0.0227044
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.7,0.6,1.7,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000217442,SYCE3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.4319% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2918% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6429% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8547% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5724% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.0824% (minimum 99%, Baseline (adaptation disabled)); liver: 98.7840% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2219% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.9964% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.7,0.6,1.7,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000217442,SYCE3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0378398,0.0256741,-0.00917614
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.4319% (minimum 99%, Missing); basal ganglia: 98.2918% (minimum 99%, Missing); cerebral cortex: 98.6429% (minimum 99%, Missing); hippocampal formation: 98.8547% (minimum 99%, Missing); hypothalamus: 98.5724% (minimum 99%, Missing); kidney: 98.0824% (minimum 99%, Missing); liver: 98.7840% (minimum 99%, Missing); midbrain: 98.2219% (minimum 99%, Missing); spinal cord: 98.9964% (minimum 99%, Missing)",0,80,unavailable,2.7,0.6,1.7,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000217442,SYCE3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0378398,0.0256741,-0.00917614
True,compatible,,True,True,False,,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000218819,TDRD15,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 85.4839% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000218819,TDRD15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.135161
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 85.4839% (minimum 99%, Missing)",0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,ENSG00000218819,TDRD15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.135161
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000218823,PAPOLB,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000218823,PAPOLB,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00315068
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000218823,PAPOLB,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00315068
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,48049.2,16.7,8.7,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 6); salivary gland: 9.5 nTPM (protected, limit 6); heart muscle: 8.1 nTPM (vital, limit 3); duodenum: 6.3 nTPM (vital, limit 3); liver: 4.9 nTPM (vital, limit 3); pituitary gland: 2.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000219073,CELA3B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.2258% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.3448% (minimum 99%, Baseline (adaptation disabled)); amygdala: 91.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 85.3448% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.5234% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.8182% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 86.0870% (minimum 99%, Baseline (adaptation disabled)); colon: 84.6154% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.1111% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.8387% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 55.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.2857% (minimum 99%, Baseline (adaptation disabled)); kidney: 86.8421% (minimum 99%, Baseline (adaptation disabled)); liver: 66.8919% (minimum 99%, Baseline (adaptation disabled)); lung: 89.1892% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.8257% (minimum 99%, Baseline (adaptation disabled)); pancreas: 0.0206% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 81.8182% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.0309% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 86.8421% (minimum 99%, Baseline (adaptation disabled)); skin: 83.8983% (minimum 95%, Baseline (adaptation disabled)); small intestine: 79.2000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 81.8182% (minimum 95%, Baseline (adaptation disabled)); stomach: 37.2180% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 89.1892% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 90.8257% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,48049.2,16.7,8.7,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 2); salivary gland: 9.5 nTPM (protected, limit 2); adipose tissue: 8.7 nTPM (manageable, limit 5); heart muscle: 8.1 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); esophagus: 2.5 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000219073,CELA3B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.417742,-0.59782,-0.989794
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.2258% (minimum 80%, Supported); adrenal gland: 85.3448% (minimum 97%, Supported); amygdala: 91.6667% (minimum 99%, Missing); basal ganglia: 85.3448% (minimum 99%, Missing); bone marrow: 92.5234% (minimum 97%, Supported); cerebellum: 81.8182% (minimum 97%, Supported); cerebral cortex: 86.0870% (minimum 97%, Supported); colon: 84.6154% (minimum 90%, Supported); duodenum: 61.1111% (minimum 97%, Supported); esophagus: 79.8387% (minimum 90%, Supported); heart muscle: 55.0000% (minimum 97%, Supported); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 94.2857% (minimum 99%, Missing); kidney: 86.8421% (minimum 97%, Supported); liver: 66.8919% (minimum 97%, Supported); lung: 89.1892% (minimum 97%, Supported); midbrain: 90.8257% (minimum 99%, Missing); pancreas: 0.0206% (minimum 99%, Missing); pituitary gland: 81.8182% (minimum 99%, Missing); salivary gland: 51.0309% (minimum 90%, Supported); skeletal muscle: 86.8421% (minimum 97%, Supported); small intestine: 79.2000% (minimum 97%, Supported); spinal cord: 91.6667% (minimum 99%, Missing); stomach: 37.2180% (minimum 90%, Supported)",0,4,partial,48049.2,16.7,8.7,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 6); salivary gland: 9.5 nTPM (protected, limit 6); heart muscle: 8.1 nTPM (vital, limit 3); duodenum: 6.3 nTPM (vital, limit 3); liver: 4.9 nTPM (vital, limit 3); pituitary gland: 2.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000219073,CELA3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.267742,-0.52782,-0.989794
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.3,0.5,1.2,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000219435,CATSPERZ,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,3.3,0.5,1.2,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000219435,CATSPERZ,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0478992,0.0291236,0.00424385
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,3.3,0.5,1.2,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000219435,CATSPERZ,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0478992,0.0291236,0.00424385
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,470.8,175.2,115.1,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 2); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); skin: 115.1 nTPM (manageable, limit 5); spleen: 112.7 nTPM (manageable, limit 5); thyroid gland: 99 nTPM (manageable, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 2); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (manageable, limit 5); stomach: 85.6 nTPM (protected, limit 2); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 2); choroid plexus: 75 nTPM (vital, limit 1); salivary gland: 70 nTPM (protected, limit 2); thymus: 69.6 nTPM (manageable, limit 5); lymph node: 68.6 nTPM (protected, limit 2); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 2); esophagus: 59.1 nTPM (protected, limit 2); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 2); duodenum: 41.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000220205,VAMP2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 65.8838% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.4254% (minimum 99%, Baseline (adaptation disabled)); amygdala: 33.6656% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 35.8303% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.3147% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 30.4676% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 26.0097% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.8150% (minimum 99%, Baseline (adaptation disabled)); colon: 64.1971% (minimum 97%, Baseline (adaptation disabled)); duodenum: 79.7975% (minimum 99%, Baseline (adaptation disabled)); esophagus: 73.6866% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 63.0957% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 33.6861% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 36.6556% (minimum 99%, Baseline (adaptation disabled)); kidney: 56.5812% (minimum 99%, Baseline (adaptation disabled)); liver: 73.9500% (minimum 99%, Baseline (adaptation disabled)); lung: 66.6801% (minimum 99%, Baseline (adaptation disabled)); lymph node: 70.6963% (minimum 97%, Baseline (adaptation disabled)); midbrain: 39.2087% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.9114% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 48.5765% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 42.7759% (minimum 99%, Baseline (adaptation disabled)); rectum: 76.9052% (minimum 97%, Baseline (adaptation disabled)); retina: 27.4598% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.2760% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 63.4829% (minimum 99%, Baseline (adaptation disabled)); skin: 58.9808% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.0295% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.7693% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 49.2413% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.4896% (minimum 95%, Baseline (adaptation disabled)); stomach: 65.9100% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.3956% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.5709% (minimum 95%, Baseline (adaptation disabled)); tongue: 73.0362% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.4167% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,470.8,175.2,115.1,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 2); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); skin: 115.1 nTPM (manageable, limit 5); spleen: 112.7 nTPM (manageable, limit 5); thyroid gland: 99 nTPM (manageable, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 2); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (manageable, limit 5); stomach: 85.6 nTPM (protected, limit 2); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 2); choroid plexus: 75 nTPM (vital, limit 1); salivary gland: 70 nTPM (protected, limit 2); thymus: 69.6 nTPM (manageable, limit 5); lymph node: 68.6 nTPM (protected, limit 2); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 2); esophagus: 59.1 nTPM (protected, limit 2); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 2); duodenum: 41.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000220205,VAMP2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.360192,-0.484235,-0.729903
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 65.8838% (minimum 95%, Missing); adrenal gland: 57.4254% (minimum 99%, Missing); amygdala: 33.6656% (minimum 99%, Missing); basal ganglia: 35.8303% (minimum 99%, Missing); bone marrow: 49.3147% (minimum 99%, Missing); cerebellum: 30.4676% (minimum 99%, Missing); cerebral cortex: 26.0097% (minimum 99%, Missing); choroid plexus: 68.8150% (minimum 99%, Missing); colon: 64.1971% (minimum 97%, Missing); duodenum: 79.7975% (minimum 99%, Missing); esophagus: 73.6866% (minimum 97%, Missing); heart muscle: 63.0957% (minimum 99%, Missing); hippocampal formation: 33.6861% (minimum 99%, Missing); hypothalamus: 36.6556% (minimum 99%, Missing); kidney: 56.5812% (minimum 99%, Missing); liver: 73.9500% (minimum 99%, Missing); lung: 66.6801% (minimum 99%, Missing); lymph node: 70.6963% (minimum 97%, Missing); midbrain: 39.2087% (minimum 99%, Missing); pancreas: 67.9114% (minimum 99%, Missing); parathyroid gland: 48.5765% (minimum 97%, Missing); pituitary gland: 42.7759% (minimum 99%, Missing); rectum: 76.9052% (minimum 97%, Missing); retina: 27.4598% (minimum 99%, Missing); salivary gland: 70.2760% (minimum 97%, Missing); skeletal muscle: 63.4829% (minimum 99%, Missing); skin: 58.9808% (minimum 95%, Missing); small intestine: 65.0295% (minimum 99%, Missing); smooth muscle: 71.7693% (minimum 99%, Missing); spinal cord: 49.2413% (minimum 99%, Missing); spleen: 59.4896% (minimum 95%, Missing); stomach: 65.9100% (minimum 97%, Missing); thymus: 70.3956% (minimum 95%, Missing); thyroid gland: 62.5709% (minimum 95%, Missing); tongue: 73.0362% (minimum 97%, Missing); urinary bladder: 68.4167% (minimum 97%, Missing)",0,80,unavailable,470.8,175.2,115.1,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 2); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); skin: 115.1 nTPM (manageable, limit 5); spleen: 112.7 nTPM (manageable, limit 5); thyroid gland: 99 nTPM (manageable, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 2); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (manageable, limit 5); stomach: 85.6 nTPM (protected, limit 2); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 2); choroid plexus: 75 nTPM (vital, limit 1); salivary gland: 70 nTPM (protected, limit 2); thymus: 69.6 nTPM (manageable, limit 5); lymph node: 68.6 nTPM (protected, limit 2); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 2); esophagus: 59.1 nTPM (protected, limit 2); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 2); duodenum: 41.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000220205,VAMP2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.360192,-0.484235,-0.729903
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000221813,OR6B1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 28.5714% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000221813,OR6B1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.704286
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 66.6667% (minimum 99%, Missing); pancreas: 28.5714% (minimum 99%, Missing)",0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000221813,OR6B1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.704286
True,compatible,,True,True,False,,0,2,partial,0.6,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000221826,PSG3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.6,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000221826,PSG3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0478214,0.0292727,0.00565217
True,compatible,,True,True,True,,0,2,partial,0.6,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000221826,PSG3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.5,0.2,0.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000221843,SPATA31H1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2143% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.2143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.2143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.4912% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.8276% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.2143% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2143% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.2143% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2143% (minimum 99%, Baseline (adaptation disabled)); liver: 94.8276% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2143% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2143% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.2203% (minimum 99%, Baseline (adaptation disabled)); retina: 78.5714% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2143% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.2143% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.4912% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.5,0.2,0.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000221843,SPATA31H1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,0.0149123,-0.00508772,-0.204286
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2143% (minimum 99%, Missing); amygdala: 98.2143% (minimum 99%, Missing); basal ganglia: 98.2143% (minimum 99%, Missing); cerebellum: 96.4912% (minimum 99%, Missing); cerebral cortex: 94.8276% (minimum 99%, Missing); duodenum: 98.2143% (minimum 99%, Missing); heart muscle: 98.2143% (minimum 99%, Missing); hippocampal formation: 98.2143% (minimum 99%, Missing); hypothalamus: 98.2143% (minimum 99%, Missing); kidney: 98.2143% (minimum 99%, Missing); liver: 94.8276% (minimum 99%, Missing); midbrain: 98.2143% (minimum 99%, Missing); pancreas: 98.2143% (minimum 99%, Missing); pituitary gland: 93.2203% (minimum 99%, Missing); retina: 78.5714% (minimum 99%, Missing); small intestine: 98.2143% (minimum 99%, Missing); spinal cord: 98.2143% (minimum 99%, Missing); stomach: 96.4912% (minimum 97%, Missing)",0,80,unavailable,1.5,0.2,0.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000221843,SPATA31H1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,0.0149123,-0.00508772,-0.204286
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000221855,TAS2R41,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000221855,TAS2R41,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000221855,TAS2R41,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,,True,True,False,,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,ENSG00000221867,MAGEA3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,ENSG00000221867,MAGEA3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,0.025,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,ENSG00000221867,MAGEA3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021;Carter 2023;Seager 2024;Loriot 2025;da Silva 2017,0.025,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0.5,0,1.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000221878,PSG7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 76.9231% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 88.8889% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.5,0,1.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000221878,PSG7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.180769,0.03,-0.101111
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 76.9231% (minimum 80%, Supported); smooth muscle: 88.8889% (minimum 97%, Supported)",0,2,partial,0.5,0,1.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000221878,PSG7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.0307692,0.03,-0.0811111
False,unresolved,incomplete_routine_rna,True,True,False,,9,80,unavailable,0.9,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000221882,OR3A2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna,True,True,True,"cerebral cortex: 87.5000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.5517% (minimum 99%, Baseline (adaptation disabled)); lung: 96.5517% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.3226% (minimum 97%, Baseline (adaptation disabled)); retina: 75.6757% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 90.3226% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.3333% (minimum 95%, Baseline (adaptation disabled)); thymus: 90.3226% (minimum 95%, Baseline (adaptation disabled))",9,80,unavailable,0.9,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000221882,OR3A2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,-0.0467742,-0.0667742,-0.233243
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna,True,True,True,"cerebral cortex: 87.5000% (minimum 99%, Missing); choroid plexus: 96.5517% (minimum 99%, Missing); lung: 96.5517% (minimum 99%, Missing); lymph node: 90.3226% (minimum 97%, Missing); retina: 75.6757% (minimum 99%, Missing); skeletal muscle: 90.3226% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Missing); thymus: 90.3226% (minimum 95%, Missing)",9,80,unavailable,0.9,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,ENSG00000221882,OR3A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Chang 2019;Wang 2016;Carter 2023,-0.0467742,-0.0667742,-0.233243
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000221888,OR1C1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.1538% (minimum 99%, Baseline (adaptation disabled)); retina: 92.5926% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000221888,OR1C1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0640741
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.1538% (minimum 99%, Missing); retina: 92.5926% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000221888,OR1C1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0640741
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000221900,POM121L12,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000221900,POM121L12,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000221900,POM121L12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000221910,OR2F2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000221910,OR2F2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000221910,OR2F2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,35.5,141.8,43.5,"esophagus: 141.8 nTPM (protected, limit 2); skin: 43.5 nTPM (manageable, limit 5); salivary gland: 36.9 nTPM (protected, limit 2); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 2); stomach: 32 nTPM (protected, limit 2); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 2); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (manageable, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 2); hypothalamus: 10.8 nTPM (vital, limit 1); thymus: 10.1 nTPM (manageable, limit 5); lymph node: 9.8 nTPM (protected, limit 2); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000221926,TRIM16,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 79.3706% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 68.3049% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.7233% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.0983% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.2782% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.0328% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.6053% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.5585% (minimum 99%, Baseline (adaptation disabled)); colon: 83.3537% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.1656% (minimum 99%, Baseline (adaptation disabled)); esophagus: 32.4440% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.3319% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.3183% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.3118% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.1361% (minimum 99%, Baseline (adaptation disabled)); liver: 92.1516% (minimum 99%, Baseline (adaptation disabled)); lung: 82.8467% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.4198% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.8070% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.0270% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.7149% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 94.0608% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.5528% (minimum 97%, Baseline (adaptation disabled)); retina: 93.8017% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.8571% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 65.7336% (minimum 99%, Baseline (adaptation disabled)); skin: 61.0215% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.5963% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.6448% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.1472% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.0270% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.0320% (minimum 97%, Baseline (adaptation disabled)); thymus: 87.0844% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.9108% (minimum 95%, Baseline (adaptation disabled)); tongue: 69.3483% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 66.1808% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,35.5,141.8,43.5,"esophagus: 141.8 nTPM (protected, limit 2); skin: 43.5 nTPM (manageable, limit 5); salivary gland: 36.9 nTPM (protected, limit 2); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 2); stomach: 32 nTPM (protected, limit 2); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 2); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (manageable, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 2); hypothalamus: 10.8 nTPM (vital, limit 1); thymus: 10.1 nTPM (manageable, limit 5); lymph node: 9.8 nTPM (protected, limit 2); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000221926,TRIM16,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.339785,-0.64556,-0.332664
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 79.3706% (minimum 95%, Uncertain); adrenal gland: 68.3049% (minimum 99%, Uncertain); amygdala: 89.7233% (minimum 99%, Missing); basal ganglia: 88.0983% (minimum 99%, Missing); bone marrow: 79.2782% (minimum 99%, Missing); cerebellum: 93.0328% (minimum 99%, Uncertain); cerebral cortex: 89.6053% (minimum 99%, Uncertain); choroid plexus: 90.5585% (minimum 99%, Missing); colon: 83.3537% (minimum 97%, Uncertain); duodenum: 75.1656% (minimum 99%, Uncertain); esophagus: 32.4440% (minimum 97%, Missing); heart muscle: 75.3319% (minimum 99%, Uncertain); hippocampal formation: 90.3183% (minimum 99%, Missing); hypothalamus: 86.3118% (minimum 99%, Missing); kidney: 89.1361% (minimum 99%, Missing); liver: 92.1516% (minimum 99%, Uncertain); lung: 82.8467% (minimum 99%, Uncertain); lymph node: 87.4198% (minimum 97%, Missing); midbrain: 84.8070% (minimum 99%, Missing); pancreas: 92.0270% (minimum 99%, Uncertain); parathyroid gland: 94.7149% (minimum 97%, Missing); pituitary gland: 94.0608% (minimum 99%, Missing); rectum: 85.5528% (minimum 97%, Uncertain); retina: 93.8017% (minimum 99%, Missing); salivary gland: 64.8571% (minimum 97%, Missing); skeletal muscle: 65.7336% (minimum 99%, Uncertain); skin: 61.0215% (minimum 95%, Missing); small intestine: 84.5963% (minimum 99%, Uncertain); smooth muscle: 87.6448% (minimum 99%, Uncertain); spinal cord: 82.1472% (minimum 99%, Missing); spleen: 92.0270% (minimum 95%, Uncertain); stomach: 68.0320% (minimum 97%, Missing); thymus: 87.0844% (minimum 95%, Missing); thyroid gland: 78.9108% (minimum 95%, Missing); tongue: 69.3483% (minimum 97%, Missing); urinary bladder: 66.1808% (minimum 97%, Missing)",0,3,partial,35.5,141.8,43.5,"esophagus: 141.8 nTPM (protected, limit 2); skin: 43.5 nTPM (manageable, limit 5); salivary gland: 36.9 nTPM (protected, limit 2); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 2); stomach: 32 nTPM (protected, limit 2); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 2); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (manageable, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 2); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 2); hypothalamus: 10.8 nTPM (vital, limit 1); thymus: 10.1 nTPM (manageable, limit 5); lymph node: 9.8 nTPM (protected, limit 2); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 2)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000221926,TRIM16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.339785,-0.64556,-0.332664
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,5.2,1.6,0.9,"small intestine: 5.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000221947,XKR9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 86.5854% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.9459% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2603% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.2603% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.6111% (minimum 99%, Baseline (adaptation disabled)); colon: 89.8734% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.1959% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.4211% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.2603% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.2603% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.9459% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 68.9320% (minimum 99%, Baseline (adaptation disabled)); lung: 92.2078% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.4211% (minimum 97%, Baseline (adaptation disabled)); midbrain: 95.9459% (minimum 99%, Baseline (adaptation disabled)); pancreas: 95.9459% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 92.2078% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.4211% (minimum 97%, Baseline (adaptation disabled)); retina: 78.0220% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.4211% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.6111% (minimum 99%, Baseline (adaptation disabled)); skin: 88.7500% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.7236% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.2603% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.9459% (minimum 99%, Baseline (adaptation disabled)); stomach: 81.6092% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.6667% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.9459% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.7500% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,5.2,1.6,0.9,"small intestine: 5.2 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000221947,XKR9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0625,-0.153908,-0.412764
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 86.5854% (minimum 99%, Missing); amygdala: 95.9459% (minimum 99%, Missing); basal ganglia: 97.2603% (minimum 99%, Missing); bone marrow: 97.2603% (minimum 99%, Missing); cerebral cortex: 94.6667% (minimum 99%, Missing); choroid plexus: 98.6111% (minimum 99%, Missing); colon: 89.8734% (minimum 97%, Missing); duodenum: 73.1959% (minimum 99%, Missing); esophagus: 93.4211% (minimum 97%, Missing); heart muscle: 97.2603% (minimum 99%, Missing); hippocampal formation: 97.2603% (minimum 99%, Missing); hypothalamus: 95.9459% (minimum 99%, Missing); kidney: 94.6667% (minimum 99%, Missing); liver: 68.9320% (minimum 95%, Enhanced); lung: 92.2078% (minimum 99%, Missing); midbrain: 95.9459% (minimum 99%, Missing); pancreas: 95.9459% (minimum 99%, Missing); pituitary gland: 92.2078% (minimum 99%, Missing); retina: 78.0220% (minimum 99%, Missing); salivary gland: 93.4211% (minimum 97%, Missing); skeletal muscle: 98.6111% (minimum 99%, Missing); skin: 88.7500% (minimum 95%, Missing); small intestine: 57.7236% (minimum 99%, Missing); spinal cord: 95.9459% (minimum 99%, Missing); stomach: 81.6092% (minimum 97%, Missing); thymus: 94.6667% (minimum 95%, Missing); thyroid gland: 94.6667% (minimum 95%, Missing); tongue: 95.9459% (minimum 97%, Missing); urinary bladder: 88.7500% (minimum 97%, Missing)",0,2,partial,5.2,1.6,0.9,"small intestine: 5.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000221947,XKR9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.0625,-0.153908,-0.412764
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000221977,OR4E2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000221977,OR4E2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000221977,OR4E2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,False,,0,4,partial,0,0,29.8,"thymus: 29.8 nTPM (manageable, limit 5)",thymus / cortical cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; thymus / cortical cells,ENSG00000222028,PSMB11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"thymus: 0.9967% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,0,0,29.8,"thymus: 29.8 nTPM (manageable, limit 5)",thymus / cortical cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; thymus / cortical cells,ENSG00000222028,PSMB11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.940033,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence,False,False,True,"thymus: 0.9967% (minimum 95%, Missing)",0,4,partial,0,0,29.8,"thymus: 29.8 nTPM (manageable, limit 5)",thymus / cortical cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; thymus / cortical cells,ENSG00000222028,PSMB11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.940033,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.8,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000222036,POTEM,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.9071% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.9071% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.9071% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.3696% (minimum 99%, Baseline (adaptation disabled)); lung: 98.9071% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.9071% (minimum 99%, Baseline (adaptation disabled)); retina: 95.7672% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000222036,POTEM,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0179144,0.0136957,-0.032328
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 98.9071% (minimum 99%, Missing); bone marrow: 98.9071% (minimum 99%, Missing); duodenum: 98.9071% (minimum 99%, Missing); heart muscle: 98.3696% (minimum 99%, Missing); lung: 98.9071% (minimum 99%, Missing); pancreas: 98.9071% (minimum 99%, Missing); retina: 95.7672% (minimum 99%, Missing)",0,80,unavailable,0.8,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000222036,POTEM,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0179144,0.0136957,-0.032328
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.8,2.6,3.2,"lymph node: 2.6 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000223510,CDRT15,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5437% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.1292% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 98.0676% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5437% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.6463% (minimum 97%, Baseline (adaptation disabled)); retina: 98.0676% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.6667% (minimum 97%, Baseline (adaptation disabled)); skin: 86.3830% (minimum 95%, Baseline (adaptation disabled)); small intestine: 96.2085% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.8,2.6,3.2,"lymph node: 2.6 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000223510,CDRT15,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,-0.0861702,-0.0835371,-0.0279147
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5437% (minimum 99%, Missing); bone marrow: 97.1292% (minimum 99%, Missing); duodenum: 96.6667% (minimum 99%, Missing); liver: 98.0676% (minimum 99%, Missing); lung: 98.5437% (minimum 99%, Missing); lymph node: 88.6463% (minimum 97%, Missing); retina: 98.0676% (minimum 99%, Missing); salivary gland: 96.6667% (minimum 97%, Missing); skin: 86.3830% (minimum 95%, Missing); small intestine: 96.2085% (minimum 99%, Missing)",0,80,unavailable,0.8,2.6,3.2,"lymph node: 2.6 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000223510,CDRT15,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,-0.0861702,-0.0835371,-0.0279147
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000223591,CENPVL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 55.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 22.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.7059% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.7500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 22.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 64.7059% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 84.6154% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.5714% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000223591,CENPVL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.05,0.03,-0.77
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 55.0000% (minimum 99%, Missing); basal ganglia: 22.0000% (minimum 99%, Missing); cerebral cortex: 64.7059% (minimum 99%, Missing); hippocampal formation: 68.7500% (minimum 99%, Missing); hypothalamus: 22.0000% (minimum 99%, Missing); midbrain: 64.7059% (minimum 99%, Missing); pituitary gland: 84.6154% (minimum 99%, Missing); spinal cord: 78.5714% (minimum 99%, Missing)",0,80,unavailable,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000223591,CENPVL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.05,0.03,-0.77
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000223601,EBLN1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 96.4286% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.4286% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.4286% (minimum 99%, Baseline (adaptation disabled)); retina: 96.4286% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.4286% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000223601,EBLN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,-0.00571429,-0.0257143
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 96.4286% (minimum 99%, Missing); lymph node: 96.4286% (minimum 97%, Missing); pituitary gland: 96.4286% (minimum 99%, Missing); retina: 96.4286% (minimum 99%, Missing); skeletal muscle: 96.4286% (minimum 99%, Missing)",0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000223601,EBLN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,-0.00571429,-0.0257143
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000223614,ZNF735,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000223614,ZNF735,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000223614,ZNF735,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,10,partial,166.6,11.3,1,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 6); skeletal muscle: 17.5 nTPM (vital, limit 6); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 2); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil,ENSG00000223802,CERS1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.4762% (minimum 99%, Baseline (adaptation disabled)); amygdala: 17.4099% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 14.6079% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 33.0243% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 16.9240% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.4336% (minimum 99%, Baseline (adaptation disabled)); colon: 89.3417% (minimum 97%, Baseline (adaptation disabled)); esophagus: 96.6102% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.1560% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 16.7549% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 21.1581% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.2696% (minimum 99%, Baseline (adaptation disabled)); lung: 98.2759% (minimum 99%, Baseline (adaptation disabled)); midbrain: 15.2081% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.2696% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 91.3462% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.6822% (minimum 99%, Baseline (adaptation disabled)); retina: 86.1027% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.9388% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 61.9565% (minimum 99%, Baseline (adaptation disabled)); small intestine: 96.9388% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.3177% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 14.9764% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.9596% (minimum 97%, Baseline (adaptation disabled)); tongue: 71.6080% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.6844% (minimum 97%, Baseline (adaptation disabled))",0,10,partial,166.6,11.3,1,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 1); skeletal muscle: 17.5 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 2); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2); adrenal gland: 3 nTPM (vital, limit 1); parathyroid gland: 2.7 nTPM (protected, limit 2); smooth muscle: 1.4 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil,ENSG00000223802,CERS1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0161017,-0.25392,-0.843921
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 90.4762% (minimum 95%, Enhanced); amygdala: 17.4099% (minimum 99%, Missing); basal ganglia: 14.6079% (minimum 99%, Missing); cerebellum: 33.0243% (minimum 95%, Enhanced); cerebral cortex: 16.9240% (minimum 99%, Missing); choroid plexus: 66.4336% (minimum 99%, Missing); colon: 89.3417% (minimum 97%, Missing); heart muscle: 87.1560% (minimum 99%, Missing); hippocampal formation: 16.7549% (minimum 99%, Missing); hypothalamus: 21.1581% (minimum 99%, Missing); midbrain: 15.2081% (minimum 99%, Missing); pituitary gland: 69.6822% (minimum 99%, Missing); retina: 86.1027% (minimum 99%, Missing); skeletal muscle: 61.9565% (minimum 95%, Enhanced); small intestine: 96.9388% (minimum 99%, Missing); spinal cord: 14.9764% (minimum 99%, Missing); tongue: 71.6080% (minimum 97%, Missing)",0,10,partial,166.6,11.3,1,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 6); skeletal muscle: 17.5 nTPM (vital, limit 6); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 2); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 2)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil,ENSG00000223802,CERS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.0395833,-0.25392,-0.843921
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000224089,CT47A10,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000224089,CT47A10,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000224089,CT47A10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000224107,ETDB,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 98.2456% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.3913% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2456% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000224107,ETDB,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.016087
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 98.2456% (minimum 99%, Missing); bone marrow: 97.3913% (minimum 99%, Missing); cerebral cortex: 98.2456% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000224107,ETDB,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.016087
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000224440,CXorf51A,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000224440,CXorf51A,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000224440,CXorf51A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000224586,GPX5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000224586,GPX5,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000224586,GPX5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,2.2,0.2,0,"retina: 2.2 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000224659,GAGE12J,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Seager 2024;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 91.0931% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,2.2,0.2,0,"retina: 2.2 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000224659,GAGE12J,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.0211894,-0.0790688
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 91.0931% (minimum 99%, Missing)",0,4,partial,2.2,0.2,0,"retina: 2.2 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000224659,GAGE12J,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Gong 2021;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,-0.0790688
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000224902,GAGE12H,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000224902,GAGE12H,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000224902,GAGE12H,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000224960,PPP4R3C,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000224960,PPP4R3C,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000224960,PPP4R3C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.4,0.9,0.9,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000225614,ZNF469,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.9677% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 81.4815% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.8571% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.6522% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.8571% (minimum 99%, Baseline (adaptation disabled)); colon: 88.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.6522% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.6154% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 61.1111% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 70.9677% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.6522% (minimum 99%, Baseline (adaptation disabled)); liver: 95.6522% (minimum 99%, Baseline (adaptation disabled)); lung: 88.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.5714% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.9677% (minimum 99%, Baseline (adaptation disabled)); pancreas: 88.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.6522% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.6522% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 84.6154% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.5714% (minimum 99%, Baseline (adaptation disabled)); skin: 88.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.6154% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.9677% (minimum 99%, Baseline (adaptation disabled)); spleen: 73.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.6154% (minimum 97%, Baseline (adaptation disabled)); thymus: 84.6154% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.6522% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 70.9677% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.4,0.9,0.9,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000225614,ZNF469,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.240323,-0.260323,-0.378889
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.9677% (minimum 95%, Missing); adrenal gland: 81.4815% (minimum 99%, Missing); amygdala: 62.8571% (minimum 99%, Missing); basal ganglia: 66.6667% (minimum 99%, Missing); bone marrow: 95.6522% (minimum 99%, Missing); cerebellum: 91.6667% (minimum 99%, Missing); cerebral cortex: 62.8571% (minimum 99%, Missing); colon: 88.0000% (minimum 97%, Missing); duodenum: 91.6667% (minimum 99%, Missing); esophagus: 95.6522% (minimum 97%, Missing); heart muscle: 84.6154% (minimum 99%, Missing); hippocampal formation: 61.1111% (minimum 99%, Missing); hypothalamus: 70.9677% (minimum 99%, Missing); kidney: 95.6522% (minimum 99%, Missing); liver: 95.6522% (minimum 99%, Missing); lung: 88.0000% (minimum 99%, Missing); lymph node: 78.5714% (minimum 97%, Missing); midbrain: 70.9677% (minimum 99%, Missing); pancreas: 88.0000% (minimum 99%, Missing); parathyroid gland: 95.6522% (minimum 97%, Missing); pituitary gland: 95.6522% (minimum 99%, Missing); salivary gland: 84.6154% (minimum 97%, Missing); skeletal muscle: 78.5714% (minimum 99%, Missing); skin: 88.0000% (minimum 95%, Missing); small intestine: 84.6154% (minimum 99%, Missing); smooth muscle: 73.3333% (minimum 99%, Missing); spinal cord: 70.9677% (minimum 99%, Missing); spleen: 73.3333% (minimum 95%, Missing); stomach: 84.6154% (minimum 97%, Missing); thymus: 84.6154% (minimum 95%, Missing); tongue: 95.6522% (minimum 97%, Missing); urinary bladder: 70.9677% (minimum 97%, Missing)",0,80,unavailable,1.4,0.9,0.9,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000225614,ZNF469,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.240323,-0.260323,-0.378889
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000225781,OR6V1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000225781,OR6V1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000225781,OR6V1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.7,4.5,8.5,"liver: 9.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); spinal cord: 4.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); pituitary gland: 3.9 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000225828,FAM229A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.7111% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.0226% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.9429% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.2278% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.5691% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.4098% (minimum 99%, Baseline (adaptation disabled)); colon: 96.9192% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 97.3244% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.3317% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.4881% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.1946% (minimum 99%, Baseline (adaptation disabled)); liver: 92.3077% (minimum 99%, Baseline (adaptation disabled)); lung: 96.5174% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.0204% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.1619% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.7581% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 96.7581% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.5605% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.5665% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.9604% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.1946% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.6777% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 94.8655% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.2779% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.7,4.5,8.5,"liver: 9.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); spinal cord: 4.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); pituitary gland: 3.9 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000225828,FAM229A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.0180544,-0.00722084,-0.0669231
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.7111% (minimum 99%, Missing); amygdala: 94.0226% (minimum 99%, Missing); basal ganglia: 94.9429% (minimum 99%, Missing); bone marrow: 98.2278% (minimum 99%, Missing); cerebellum: 93.5691% (minimum 99%, Missing); cerebral cortex: 95.4098% (minimum 99%, Missing); colon: 96.9192% (minimum 97%, Missing); heart muscle: 97.3244% (minimum 99%, Missing); hippocampal formation: 95.3317% (minimum 99%, Missing); hypothalamus: 95.4881% (minimum 99%, Missing); kidney: 93.1946% (minimum 99%, Missing); liver: 92.3077% (minimum 99%, Missing); lung: 96.5174% (minimum 99%, Missing); midbrain: 95.0204% (minimum 99%, Missing); pancreas: 97.1619% (minimum 99%, Missing); pituitary gland: 96.7581% (minimum 99%, Missing); salivary gland: 96.7581% (minimum 97%, Missing); skeletal muscle: 98.5605% (minimum 99%, Missing); small intestine: 95.5665% (minimum 99%, Missing); spinal cord: 95.9604% (minimum 99%, Missing); spleen: 93.1946% (minimum 95%, Missing); stomach: 96.6777% (minimum 97%, Missing); thyroid gland: 94.8655% (minimum 95%, Missing); urinary bladder: 96.2779% (minimum 97%, Missing)",0,80,unavailable,9.7,4.5,8.5,"liver: 9.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); spinal cord: 4.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 2); lung: 4.2 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 2); pituitary gland: 3.9 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 2); colon: 3.7 nTPM (protected, limit 2); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); esophagus: 2.7 nTPM (protected, limit 2); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000225828,FAM229A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.0180544,-0.00722084,-0.0669231
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226023,CT47A6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226023,CT47A6,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226023,CT47A6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,3,partial,0,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),52,not_established,not_triggered,,,ENSG00000226372,DCAF8L1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,3,partial,0,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),52,not_established,not_triggered,,,ENSG00000226372,DCAF8L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted,True,True,True,,0,3,partial,0,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),52,not_established,not_triggered,,,ENSG00000226372,DCAF8L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226600,CT47A9,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226600,CT47A9,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226600,CT47A9,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000226650,KIF4B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000226650,KIF4B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000226650,KIF4B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226685,CT47A12,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226685,CT47A12,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226685,CT47A12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226929,CT47A11,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226929,CT47A11,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000226929,CT47A11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000226941,RBMY1J,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000226941,RBMY1J,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000226941,RBMY1J,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000227059,ANHX,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000227059,ANHX,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000227059,ANHX,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.6,8.1,9.7,"skin: 9.7 nTPM (manageable, limit 5); kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 2); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); salivary gland: 7 nTPM (protected, limit 2); spleen: 6.9 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 2); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 2); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000227124,ZNF717,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.3769% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 72.8155% (minimum 99%, Baseline (adaptation disabled)); amygdala: 77.3196% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 74.6269% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.7458% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 78.5340% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 77.7202% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 78.9474% (minimum 99%, Baseline (adaptation disabled)); colon: 75.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.1707% (minimum 99%, Baseline (adaptation disabled)); esophagus: 74.2574% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 72.4638% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.7576% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 74.2574% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.9756% (minimum 99%, Baseline (adaptation disabled)); liver: 66.0793% (minimum 99%, Baseline (adaptation disabled)); lung: 76.9231% (minimum 99%, Baseline (adaptation disabled)); lymph node: 76.1421% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.8916% (minimum 99%, Baseline (adaptation disabled)); pancreas: 63.2911% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 64.9351% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.5000% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.7674% (minimum 97%, Baseline (adaptation disabled)); retina: 66.6667% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.1818% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.5340% (minimum 99%, Baseline (adaptation disabled)); skin: 60.7287% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 78.5340% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.7547% (minimum 99%, Baseline (adaptation disabled)); spleen: 68.4932% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.5676% (minimum 97%, Baseline (adaptation disabled)); thymus: 76.1421% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.9835% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.1250% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 72.8155% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,9.6,8.1,9.7,"skin: 9.7 nTPM (manageable, limit 5); kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 2); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); salivary gland: 7 nTPM (protected, limit 2); spleen: 6.9 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 2); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 2); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000227124,ZNF717,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.342713,-0.320649,-0.380244
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 75.3769% (minimum 95%, Missing); adrenal gland: 72.8155% (minimum 99%, Missing); amygdala: 77.3196% (minimum 99%, Missing); basal ganglia: 74.6269% (minimum 99%, Missing); bone marrow: 84.7458% (minimum 99%, Missing); cerebellum: 78.5340% (minimum 99%, Missing); cerebral cortex: 77.7202% (minimum 99%, Missing); choroid plexus: 78.9474% (minimum 99%, Missing); colon: 75.0000% (minimum 97%, Missing); duodenum: 73.1707% (minimum 99%, Missing); esophagus: 74.2574% (minimum 97%, Missing); heart muscle: 72.4638% (minimum 99%, Missing); hippocampal formation: 75.7576% (minimum 99%, Missing); hypothalamus: 74.2574% (minimum 99%, Missing); kidney: 60.9756% (minimum 99%, Missing); liver: 66.0793% (minimum 99%, Missing); lung: 76.9231% (minimum 99%, Missing); lymph node: 76.1421% (minimum 97%, Missing); midbrain: 73.8916% (minimum 99%, Missing); pancreas: 63.2911% (minimum 99%, Missing); parathyroid gland: 64.9351% (minimum 97%, Missing); pituitary gland: 62.5000% (minimum 99%, Missing); rectum: 69.7674% (minimum 97%, Missing); retina: 66.6667% (minimum 99%, Missing); salivary gland: 68.1818% (minimum 97%, Missing); skeletal muscle: 78.5340% (minimum 99%, Missing); skin: 60.7287% (minimum 95%, Missing); small intestine: 75.0000% (minimum 99%, Missing); smooth muscle: 78.5340% (minimum 99%, Missing); spinal cord: 70.7547% (minimum 99%, Missing); spleen: 68.4932% (minimum 95%, Missing); stomach: 67.5676% (minimum 97%, Missing); thymus: 76.1421% (minimum 95%, Missing); thyroid gland: 61.9835% (minimum 95%, Missing); tongue: 78.1250% (minimum 97%, Missing); urinary bladder: 72.8155% (minimum 97%, Missing)",0,80,unavailable,9.6,8.1,9.7,"skin: 9.7 nTPM (manageable, limit 5); kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 2); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); salivary gland: 7 nTPM (protected, limit 2); spleen: 6.9 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 2); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 2); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 2); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 2); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000227124,ZNF717,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.342713,-0.320649,-0.380244
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000227151,PRR20D,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000227151,PRR20D,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000227151,PRR20D,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,3,partial,0.3,1,0.6,,,51,not_established,not_triggered,,,ENSG00000227234,SPANXB1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0.3,1,0.6,,,51,not_established,not_triggered,,,ENSG00000227234,SPANXB1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,0.0430955,0.0185452,0.0065358
True,compatible,,True,True,True,,0,3,partial,0.3,1,0.6,,,51,not_established,not_triggered,,,ENSG00000227234,SPANXB1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.0185452,0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000227488,GAGE12D,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000227488,GAGE12D,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000227488,GAGE12D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.6,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,ENSG00000227868,TEX46,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.6,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,ENSG00000227868,TEX46,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.042629,0.0263009,0.00262899
True,compatible,,True,True,True,,0,80,unavailable,0.6,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,ENSG00000227868,TEX46,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.042629,0.0263009,0.00262899
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000228075,BOD1L2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000228075,BOD1L2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00962798
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000228075,BOD1L2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.00962798
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,False,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000228372,SMIM10L2B-AS1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000228372,SMIM10L2B-AS1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000228372,SMIM10L2B-AS1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000228517,CT47A7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000228517,CT47A7,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000228517,CT47A7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000228567,VN1R4,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000228567,VN1R4,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000228567,VN1R4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,1,partial,4.8,0.1,0.1,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000228836,CT45A5,reproductive_required,False,True,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 86.2069% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 51.0204% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 92.5926% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.3396% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.0392% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.0392% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.5926% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.7576% (minimum 99%, Baseline (adaptation disabled)); lung: 98.0392% (minimum 99%, Baseline (adaptation disabled)); midbrain: 92.5926% (minimum 99%, Baseline (adaptation disabled)); pancreas: 87.7193% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 72.4638% (minimum 99%, Baseline (adaptation disabled)); retina: 83.3333% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.0392% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.0392% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.9091% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,4.8,0.1,0.1,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000228836,CT45A5,current_fixed,False,True,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.0303922,0.0103922,-0.479796
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 86.2069% (minimum 99%, Missing); basal ganglia: 51.0204% (minimum 99%, Missing); bone marrow: 92.5926% (minimum 97%, Supported); cerebral cortex: 94.3396% (minimum 97%, Supported); hippocampal formation: 92.5926% (minimum 99%, Missing); hypothalamus: 75.7576% (minimum 99%, Missing); midbrain: 92.5926% (minimum 99%, Missing); pancreas: 87.7193% (minimum 97%, Supported); pituitary gland: 72.4638% (minimum 99%, Missing); retina: 83.3333% (minimum 99%, Missing); spinal cord: 90.9091% (minimum 99%, Missing)",0,1,partial,4.8,0.1,0.1,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000228836,CT45A5,current_adaptive,False,True,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.479796
True,compatible,,True,True,False,,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,ENSG00000228927,TSPY3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 93.5484% (minimum 97%, Baseline (adaptation disabled))",0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,ENSG00000228927,TSPY3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,-0.0345161,0.01
True,compatible,,True,True,True,,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,ENSG00000228927,TSPY3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.6,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000229292,RFPL4AL1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"amygdala: 66.6667% (minimum 99%, Baseline (adaptation disabled)); liver: 25.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 40.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000229292,RFPL4AL1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.55,0.03,-0.74
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"amygdala: 66.6667% (minimum 99%, Missing); liver: 25.0000% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); spleen: 40.0000% (minimum 95%, Missing)",0,80,unavailable,0.6,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000229292,RFPL4AL1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.55,0.03,-0.74
True,compatible,,True,True,False,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000229549,TSPY8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000229549,TSPY8,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000229549,TSPY8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000229665,PRR20C,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000229665,PRR20C,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000229665,PRR20C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.5,0.3,0.7,"bone marrow: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000229676,ZNF492,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.3636% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 43.1818% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.4762% (minimum 99%, Baseline (adaptation disabled)); colon: 90.4762% (minimum 97%, Baseline (adaptation disabled)); esophagus: 90.4762% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.4762% (minimum 99%, Baseline (adaptation disabled)); lung: 95.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 86.3636% (minimum 97%, Baseline (adaptation disabled)); pancreas: 90.4762% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.3636% (minimum 97%, Baseline (adaptation disabled)); rectum: 86.3636% (minimum 97%, Baseline (adaptation disabled)); retina: 90.4762% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 82.6087% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 90.4762% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.4762% (minimum 95%, Baseline (adaptation disabled)); stomach: 95.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 73.0769% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 86.3636% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.5,0.3,0.7,"bone marrow: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000229676,ZNF492,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.219231,-0.106364,-0.558182
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 86.3636% (minimum 95%, Missing); bone marrow: 43.1818% (minimum 99%, Missing); cerebral cortex: 90.4762% (minimum 99%, Missing); colon: 90.4762% (minimum 97%, Missing); esophagus: 90.4762% (minimum 97%, Missing); heart muscle: 95.0000% (minimum 99%, Missing); kidney: 90.4762% (minimum 99%, Missing); lung: 95.0000% (minimum 99%, Missing); lymph node: 86.3636% (minimum 97%, Missing); pancreas: 90.4762% (minimum 99%, Missing); parathyroid gland: 86.3636% (minimum 97%, Missing); rectum: 86.3636% (minimum 97%, Missing); retina: 90.4762% (minimum 99%, Missing); salivary gland: 95.0000% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); skin: 82.6087% (minimum 95%, Missing); small intestine: 95.0000% (minimum 99%, Missing); smooth muscle: 90.4762% (minimum 99%, Missing); spleen: 90.4762% (minimum 95%, Missing); stomach: 95.0000% (minimum 97%, Missing); thymus: 73.0769% (minimum 95%, Missing); thyroid gland: 86.3636% (minimum 95%, Missing); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 95.0000% (minimum 97%, Missing)",0,80,unavailable,2.5,0.3,0.7,"bone marrow: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000229676,ZNF492,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.219231,-0.106364,-0.558182
True,compatible,,True,True,False,,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000229894,GK3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Jamin 2021;Bruggeman 2018;Gong 2021;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.9466% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000229894,GK3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Jamin 2021;Bruggeman 2018;Gong 2021;Carter 2023,0.0421875,0.03,-0.0205344
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.9466% (minimum 99%, Missing)",0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000229894,GK3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Jamin 2021;Bruggeman 2018;Gong 2021;Carter 2023,0.0421875,0.03,-0.0205344
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000229937,PRPS1L1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000229937,PRPS1L1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000229937,PRPS1L1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000229972,IQCF3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000229972,IQCF3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00612403
True,compatible,,True,True,True,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000229972,IQCF3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.00612403
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230031,POTEB2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230031,POTEB2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230031,POTEB2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.3,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000230054,TEX53,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.3,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000230054,TEX53,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.044003,0.028494,0.0054955
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.3,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000230054,TEX53,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.044003,0.028494,0.0054955
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230178,OR4F3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230178,OR4F3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230178,OR4F3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna,True,True,False,,9,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000230246,SPATA31C1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna,True,True,True,"bone marrow: 92.2078% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6111% (minimum 99%, Baseline (adaptation disabled))",9,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000230246,SPATA31C1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.0679221
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna,True,True,True,"bone marrow: 92.2078% (minimum 99%, Missing); cerebral cortex: 98.6111% (minimum 99%, Missing)",9,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000230246,SPATA31C1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.0679221
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230268,SSU72L6,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230268,SSU72L6,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230268,SSU72L6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230301,OR5H6,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230301,OR5H6,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230301,OR5H6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000230347,CT47A8,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000230347,CT47A8,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000230347,CT47A8,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230522,MBD3L2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230522,MBD3L2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000230522,MBD3L2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000230594,CT47A4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000230594,CT47A4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000230594,CT47A4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000230601,TEX48,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000230601,TEX48,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.00227799
True,compatible,,True,True,True,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000230601,TEX48,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.00227799
True,compatible,,True,True,False,,0,3,partial,0.5,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000231256,CFAP97D1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.9925% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7273% (minimum 99%, Baseline (adaptation disabled)); retina: 97.7273% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.2687% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.5,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000231256,CFAP97D1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0272727,0.0223077,-0.0273134
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 96.9925% (minimum 98%, Approved); pancreas: 97.7273% (minimum 98%, Approved); retina: 97.7273% (minimum 99%, Missing); skeletal muscle: 96.2687% (minimum 98%, Approved)",0,3,partial,0.5,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000231256,CFAP97D1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.0173134
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.8,229.6,1.3,"salivary gland: 229.6 nTPM (protected, limit 2); esophagus: 10.7 nTPM (protected, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,ENSG00000231887,PRH1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.6190% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.6254% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.6254% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1197% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.6254% (minimum 99%, Baseline (adaptation disabled)); esophagus: 84.2878% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.2877% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.9522% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.6190% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.9522% (minimum 99%, Baseline (adaptation disabled)); liver: 96.9595% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1197% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.6190% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6254% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.7908% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 20.0000% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.6254% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.6330% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.8,229.6,1.3,"salivary gland: 229.6 nTPM (protected, limit 2); esophagus: 10.7 nTPM (protected, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,ENSG00000231887,PRH1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0278535,-0.77,-0.0520915
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.6190% (minimum 99%, Missing); amygdala: 98.6254% (minimum 99%, Missing); basal ganglia: 98.6254% (minimum 99%, Missing); cerebellum: 98.1197% (minimum 99%, Missing); cerebral cortex: 98.6254% (minimum 99%, Missing); esophagus: 84.2878% (minimum 97%, Missing); heart muscle: 98.2877% (minimum 99%, Missing); hippocampal formation: 97.9522% (minimum 99%, Missing); hypothalamus: 97.6190% (minimum 99%, Missing); kidney: 97.9522% (minimum 99%, Missing); liver: 96.9595% (minimum 99%, Missing); lung: 98.1197% (minimum 99%, Missing); midbrain: 97.6190% (minimum 99%, Missing); pancreas: 98.6254% (minimum 99%, Missing); pituitary gland: 93.7908% (minimum 99%, Missing); salivary gland: 20.0000% (minimum 97%, Missing); small intestine: 98.6254% (minimum 99%, Missing); spinal cord: 96.6330% (minimum 99%, Missing)",0,80,unavailable,3.8,229.6,1.3,"salivary gland: 229.6 nTPM (protected, limit 2); esophagus: 10.7 nTPM (protected, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,ENSG00000231887,PRH1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0278535,-0.77,-0.0520915
True,compatible,,True,True,False,,0,2,partial,0.5,0.4,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000231924,PSG1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,,True,True,True,,0,2,partial,0.5,0.4,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000231924,PSG1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0476303,0.028419,0.0080245
True,compatible,,True,True,True,,0,2,partial,0.5,0.4,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000231924,PSG1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.00960427
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000231989,PPP1R2B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000231989,PPP1R2B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,0.05,0.03,0.0053271
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000231989,PPP1R2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021,0.05,0.03,0.0053271
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232030,MAGEB6B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232030,MAGEB6B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232030,MAGEB6B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.9,0.9,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000232040,SCAND3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.4444% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.5909% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.4066% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.8372% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 81.7308% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.3913% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.7011% (minimum 99%, Baseline (adaptation disabled)); colon: 95.5056% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.7011% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.7011% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.5909% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.3913% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.3978% (minimum 99%, Baseline (adaptation disabled)); liver: 88.5417% (minimum 99%, Baseline (adaptation disabled)); lung: 95.5056% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.7011% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.3978% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.4255% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.4066% (minimum 99%, Baseline (adaptation disabled)); rectum: 94.4444% (minimum 97%, Baseline (adaptation disabled)); retina: 85.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.3913% (minimum 97%, Baseline (adaptation disabled)); small intestine: 97.7011% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.5909% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8372% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.5909% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 84.1584% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.9,0.9,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000232040,SCAND3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.108416,-0.0657447,-0.172692
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 94.4444% (minimum 99%, Missing); amygdala: 96.5909% (minimum 99%, Missing); basal ganglia: 93.4066% (minimum 99%, Missing); bone marrow: 98.8372% (minimum 99%, Missing); cerebellum: 81.7308% (minimum 99%, Missing); cerebral cortex: 92.3913% (minimum 99%, Missing); choroid plexus: 97.7011% (minimum 99%, Missing); colon: 95.5056% (minimum 97%, Missing); duodenum: 97.7011% (minimum 99%, Missing); heart muscle: 97.7011% (minimum 99%, Missing); hippocampal formation: 96.5909% (minimum 99%, Missing); hypothalamus: 92.3913% (minimum 99%, Missing); kidney: 91.3978% (minimum 99%, Missing); liver: 88.5417% (minimum 99%, Missing); lung: 95.5056% (minimum 99%, Missing); midbrain: 97.7011% (minimum 99%, Missing); pancreas: 91.3978% (minimum 99%, Missing); parathyroid gland: 90.4255% (minimum 97%, Missing); pituitary gland: 93.4066% (minimum 99%, Missing); rectum: 94.4444% (minimum 97%, Missing); retina: 85.0000% (minimum 99%, Missing); salivary gland: 92.3913% (minimum 97%, Missing); small intestine: 97.7011% (minimum 99%, Missing); smooth muscle: 96.5909% (minimum 99%, Missing); spinal cord: 98.8372% (minimum 99%, Missing); stomach: 96.5909% (minimum 97%, Missing); thyroid gland: 84.1584% (minimum 95%, Missing)",0,80,unavailable,1.9,0.9,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,ENSG00000232040,SCAND3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Jamin 2021;Chang 2019;Wang 2016,-0.108416,-0.0657447,-0.172692
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232113,TEX50,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232113,TEX50,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232113,TEX50,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232423,PRAMEF6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232423,PRAMEF6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232423,PRAMEF6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232948,DEFB130A,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232948,DEFB130A,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000232948,DEFB130A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233050,DEFB130B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233050,DEFB130B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233050,DEFB130B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;incomplete_routine_rna,True,True,False,,9,80,unavailable,1.5,0.4,1.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000233056,ERVH48-1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"retina: 98.9967% (minimum 99%, Baseline (adaptation disabled))",9,80,unavailable,1.5,0.4,1.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000233056,ERVH48-1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0419571,0.0273046,-3.34448e-05
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"retina: 98.9967% (minimum 99%, Missing)",9,80,unavailable,1.5,0.4,1.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000233056,ERVH48-1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0419571,0.0273046,-3.34448e-05
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233412,OR5H15,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233412,OR5H15,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233412,OR5H15,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000233436,BTBD18,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 95.4545% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.4545% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.3043% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.4545% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.4545% (minimum 99%, Baseline (adaptation disabled)); retina: 95.4545% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.4545% (minimum 99%, Baseline (adaptation disabled)); skin: 91.3043% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000233436,BTBD18,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0369565,0.03,-0.0769565
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 95.4545% (minimum 99%, Missing); bone marrow: 95.4545% (minimum 99%, Missing); cerebellum: 91.3043% (minimum 99%, Missing); cerebral cortex: 95.4545% (minimum 99%, Missing); kidney: 95.4545% (minimum 99%, Missing); retina: 95.4545% (minimum 99%, Missing); skeletal muscle: 95.4545% (minimum 99%, Missing); skin: 91.3043% (minimum 95%, Missing)",0,80,unavailable,0.2,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000233436,BTBD18,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.0369565,0.03,-0.0769565
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000233701,PRR23C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 90.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000233701,PRR23C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,0.05,0.03,-0.09
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"retina: 90.0000% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000233701,PRR23C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Wang 2016;Gong 2021,0.05,0.03,-0.09
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233802,TRIM49D2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233802,TRIM49D2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233802,TRIM49D2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000233803,TSPY4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000233803,TSPY4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.04375,0.03,0.0068652
True,compatible,,True,True,True,,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000233803,TSPY4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233917,POTEB,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233917,POTEB,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000233917,POTEB,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,2,partial,0.2,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus; tonsil,ENSG00000234068,PAGE2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.2,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus; tonsil,ENSG00000234068,PAGE2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.0318841,0.0190511,0.00267399
True,compatible,,True,True,True,,0,2,partial,0.2,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus; tonsil,ENSG00000234068,PAGE2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Carter 2023;Loriot 2025;da Silva 2017,0.042674,0.03,0.00632353
True,compatible,,True,True,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000234186,C16orf82,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000234186,C16orf82,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.00888476
True,compatible,,True,True,True,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000234186,C16orf82,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.00888476
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000234278,PRR20E,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000234278,PRR20E,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000234278,PRR20E,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,6.9,3,3.6,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); lymph node: 3 nTPM (protected, limit 2); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000234284,ZNF879,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 73.1707% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.9474% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 77.9221% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.2353% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.1429% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 74.0741% (minimum 97%, Baseline (adaptation disabled)); duodenum: 84.5070% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.9494% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.7674% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 78.9474% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.1707% (minimum 99%, Baseline (adaptation disabled)); liver: 81.0811% (minimum 99%, Baseline (adaptation disabled)); lung: 75.9494% (minimum 99%, Baseline (adaptation disabled)); lymph node: 66.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 77.9221% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.9474% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.4286% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.5882% (minimum 99%, Baseline (adaptation disabled)); rectum: 84.5070% (minimum 97%, Baseline (adaptation disabled)); retina: 46.5116% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.0741% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 74.0741% (minimum 99%, Baseline (adaptation disabled)); skin: 63.8298% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.9231% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.1707% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 76.9231% (minimum 99%, Baseline (adaptation disabled)); spleen: 65.9341% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.9221% (minimum 97%, Baseline (adaptation disabled)); thymus: 64.5161% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.5000% (minimum 95%, Baseline (adaptation disabled)); tongue: 66.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.9231% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,6.9,3,3.6,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); lymph node: 3 nTPM (protected, limit 2); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000234284,ZNF879,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.325,-0.303333,-0.524884
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 73.1707% (minimum 95%, Missing); adrenal gland: 80.0000% (minimum 99%, Missing); amygdala: 78.9474% (minimum 99%, Missing); basal ganglia: 77.9221% (minimum 99%, Missing); bone marrow: 88.2353% (minimum 99%, Missing); cerebellum: 57.1429% (minimum 99%, Missing); cerebral cortex: 75.0000% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 74.0741% (minimum 97%, Missing); duodenum: 84.5070% (minimum 99%, Missing); esophagus: 75.9494% (minimum 97%, Missing); heart muscle: 69.7674% (minimum 99%, Missing); hippocampal formation: 78.9474% (minimum 99%, Missing); hypothalamus: 80.0000% (minimum 99%, Missing); kidney: 73.1707% (minimum 99%, Missing); liver: 81.0811% (minimum 99%, Missing); lung: 75.9494% (minimum 99%, Missing); lymph node: 66.6667% (minimum 97%, Missing); midbrain: 77.9221% (minimum 99%, Missing); pancreas: 78.9474% (minimum 99%, Missing); parathyroid gland: 71.4286% (minimum 97%, Missing); pituitary gland: 70.5882% (minimum 99%, Missing); rectum: 84.5070% (minimum 97%, Missing); retina: 46.5116% (minimum 99%, Missing); salivary gland: 74.0741% (minimum 97%, Missing); skeletal muscle: 74.0741% (minimum 99%, Uncertain); skin: 63.8298% (minimum 95%, Missing); small intestine: 76.9231% (minimum 99%, Missing); smooth muscle: 73.1707% (minimum 99%, Uncertain); spinal cord: 76.9231% (minimum 99%, Missing); spleen: 65.9341% (minimum 95%, Uncertain); stomach: 77.9221% (minimum 97%, Missing); thymus: 64.5161% (minimum 95%, Missing); thyroid gland: 62.5000% (minimum 95%, Missing); tongue: 66.6667% (minimum 97%, Missing); urinary bladder: 76.9231% (minimum 97%, Missing)",0,6,partial,6.9,3,3.6,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); lymph node: 3 nTPM (protected, limit 2); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); colon: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000234284,ZNF879,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.325,-0.303333,-0.524884
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,False,,0,3,partial,1.9,1.4,1.5,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000234289,H2BC12L,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"adipose tissue: 60.8696% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 70.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 93.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.5000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 51.8519% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 73.6842% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.5000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 42.4242% (minimum 99%, Baseline (adaptation disabled)); lung: 60.8696% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.3333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 82.3529% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 70.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.6364% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.3529% (minimum 99%, Baseline (adaptation disabled)); spleen: 48.2759% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.0000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 66.6667% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 82.3529% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,1.9,1.4,1.5,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000234289,H2BC12L,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.467241,-0.47,-0.565758
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"adipose tissue: 60.8696% (minimum 95%, Missing); adrenal gland: 70.0000% (minimum 99%, Missing); amygdala: 93.3333% (minimum 99%, Missing); basal ganglia: 87.5000% (minimum 99%, Missing); bone marrow: 93.3333% (minimum 99%, Missing); cerebral cortex: 93.3333% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); duodenum: 93.3333% (minimum 99%, Missing); esophagus: 51.8519% (minimum 97%, Missing); heart muscle: 73.6842% (minimum 99%, Missing); hippocampal formation: 87.5000% (minimum 99%, Missing); hypothalamus: 93.3333% (minimum 99%, Missing); kidney: 87.5000% (minimum 99%, Missing); liver: 42.4242% (minimum 99%, Missing); lung: 60.8696% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 87.5000% (minimum 99%, Missing); pancreas: 58.3333% (minimum 99%, Missing); pituitary gland: 82.3529% (minimum 99%, Missing); salivary gland: 70.0000% (minimum 97%, Missing); skeletal muscle: 93.3333% (minimum 99%, Missing); skin: 70.0000% (minimum 95%, Missing); small intestine: 63.6364% (minimum 99%, Missing); spinal cord: 82.3529% (minimum 99%, Missing); spleen: 48.2759% (minimum 95%, Missing); stomach: 70.0000% (minimum 97%, Missing); thyroid gland: 66.6667% (minimum 95%, Missing); urinary bladder: 82.3529% (minimum 97%, Missing)",0,3,partial,1.9,1.4,1.5,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000234289,H2BC12L,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,-0.467241,-0.47,-0.565758
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,9.3,0.7,1.5,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000234409,CCDC188,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4887% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.7374% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2637% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.7374% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.9904% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.5432% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.9950% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.2412% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.4887% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.2412% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.0952% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7500% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.7500% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.7374% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 80.7851% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.4887% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.4887% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7374% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,9.3,0.7,1.5,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000234409,CCDC188,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0130542,0.0124121,-0.182149
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.4887% (minimum 99%, Missing); amygdala: 98.7374% (minimum 99%, Missing); basal ganglia: 97.2637% (minimum 99%, Missing); bone marrow: 98.7374% (minimum 99%, Missing); cerebellum: 93.9904% (minimum 99%, Missing); cerebral cortex: 96.5432% (minimum 99%, Missing); choroid plexus: 97.9950% (minimum 99%, Missing); duodenum: 98.2412% (minimum 99%, Missing); heart muscle: 98.4887% (minimum 99%, Missing); hippocampal formation: 98.2412% (minimum 99%, Missing); hypothalamus: 93.0952% (minimum 99%, Missing); kidney: 97.7500% (minimum 99%, Missing); lung: 97.7500% (minimum 99%, Missing); midbrain: 97.7500% (minimum 99%, Missing); pancreas: 98.7374% (minimum 99%, Missing); pituitary gland: 80.7851% (minimum 99%, Missing); skeletal muscle: 98.4887% (minimum 99%, Missing); small intestine: 98.4887% (minimum 99%, Missing); spinal cord: 98.7374% (minimum 99%, Missing)",0,80,unavailable,9.3,0.7,1.5,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000234409,CCDC188,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0130542,0.0124121,-0.182149
True,compatible,,True,True,False,,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,ENSG00000234414,RBMY1A1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,ENSG00000234414,RBMY1A1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,ENSG00000234414,RBMY1A1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000234469,CLDN34,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 94.1176% (minimum 97%, Baseline (adaptation disabled)); kidney: 94.1176% (minimum 99%, Baseline (adaptation disabled)); liver: 94.1176% (minimum 99%, Baseline (adaptation disabled)); lung: 94.1176% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.1176% (minimum 99%, Baseline (adaptation disabled)); retina: 76.1905% (minimum 99%, Baseline (adaptation disabled)); skin: 88.8889% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.1176% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000234469,CLDN34,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.0611111,-0.0288235,-0.228095
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 94.1176% (minimum 97%, Missing); kidney: 94.1176% (minimum 99%, Missing); liver: 94.1176% (minimum 99%, Missing); lung: 94.1176% (minimum 99%, Missing); pancreas: 94.1176% (minimum 99%, Missing); retina: 76.1905% (minimum 99%, Missing); skin: 88.8889% (minimum 95%, Missing); urinary bladder: 94.1176% (minimum 97%, Missing)",0,80,unavailable,0.5,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000234469,CLDN34,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,-0.0611111,-0.0288235,-0.228095
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.5,2.2,3.5,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000234511,C5orf58,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.9359% (minimum 99%, Baseline (adaptation disabled)); lung: 97.7528% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.9105% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.5326% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,7.5,2.2,3.5,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000234511,C5orf58,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0335139,0.0195735,-0.0246741
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 96.9359% (minimum 99%, Missing); lung: 97.7528% (minimum 99%, Missing); midbrain: 98.9105% (minimum 99%, Missing); spinal cord: 96.5326% (minimum 99%, Missing)",0,80,unavailable,7.5,2.2,3.5,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000234511,C5orf58,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0335139,0.0195735,-0.0246741
True,compatible,,True,True,False,,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,ENSG00000234776,FREY1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,ENSG00000234776,FREY1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.0243925,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,ENSG00000234776,FREY1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.0243925,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,ENSG00000234828,IQCM,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"colon: 93.6170% (minimum 97%, Baseline (adaptation disabled)); rectum: 93.6170% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,ENSG00000234828,IQCM,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,-0.0338298,0.01
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"colon: 93.6170% (minimum 97%, Missing); rectum: 93.6170% (minimum 97%, Missing)",0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,ENSG00000234828,IQCM,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,-0.0338298,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000235608,NKX1-1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"pituitary gland: 83.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000235608,NKX1-1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.156667
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"pituitary gland: 83.3333% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000235608,NKX1-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.156667
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.4,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000235631,RNF148,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.9669% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.4,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000235631,RNF148,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.045842,0.0217184,-0.000330579
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 98.9669% (minimum 99%, Missing)",0,80,unavailable,0.5,0.4,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,ENSG00000235631,RNF148,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.045842,0.0217184,-0.000330579
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000235699,CXorf51B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000235699,CXorf51B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000235699,CXorf51B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000236027,PATE3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000236027,PATE3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000236027,PATE3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000236032,OR5H14,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 60.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000236032,OR5H14,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.2,0.03,-0.39
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"bone marrow: 60.0000% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); retina: 75.0000% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing)",0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000236032,OR5H14,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.2,0.03,-0.39
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000236126,CT47A3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000236126,CT47A3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000236126,CT47A3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,1.7,8.3,0,"stomach: 8.3 nTPM (protected, limit 6); retina: 1.7 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000236362,GAGE12F,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.3810% (minimum 99%, Baseline (adaptation disabled)); stomach: 92.5627% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,1.7,8.3,0,"stomach: 8.3 nTPM (protected, limit 2); retina: 1.7 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000236362,GAGE12F,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,-0.0443728,-0.00619048
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.3810% (minimum 99%, Missing)",0,4,partial,1.7,8.3,0,"stomach: 8.3 nTPM (protected, limit 6); retina: 1.7 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000236362,GAGE12F,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.0256272,-0.00619048
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000236371,CT47A1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000236371,CT47A1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000236371,CT47A1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000236396,SLC35G4,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000236396,SLC35G4,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000236396,SLC35G4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,1,partial,0,0,0.1,,,55,not_established,not_triggered,,,ENSG00000236424,TSPY10,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0.1,,,55,not_established,not_triggered,,,ENSG00000236424,TSPY10,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0.1,,,55,not_established,not_triggered,,,ENSG00000236424,TSPY10,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000236446,CT47B1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000236446,CT47B1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000236446,CT47B1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3,2.5,1.2,"basal ganglia: 3 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000236737,GAGE12B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 97.8678% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9935% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8514% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.9224% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3,2.5,1.2,"basal ganglia: 3 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000236737,GAGE12B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0413607,0.0121683,-0.011322
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 97.8678% (minimum 99%, Missing); cerebellum: 98.9935% (minimum 99%, Missing); hypothalamus: 98.8514% (minimum 99%, Missing); pituitary gland: 98.9224% (minimum 99%, Missing)",0,80,unavailable,3,2.5,1.2,"basal ganglia: 3 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000236737,GAGE12B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.0413607,0.0121683,-0.011322
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000236761,CTAGE9,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"small intestine: 98.7805% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000236761,CTAGE9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Gong 2021;Carter 2023;da Silva 2017,0.0378049,0.00590361,-0.00219512
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"small intestine: 98.7805% (minimum 99%, Missing)",0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000236761,CTAGE9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Gong 2021;Carter 2023;da Silva 2017,0.0378049,0.00590361,-0.00219512
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000236980,CIMIP7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000236980,CIMIP7,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000236980,CIMIP7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000237136,C4orf51,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000237136,C4orf51,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000237136,C4orf51,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000237247,MBD3L5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000237247,MBD3L5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000237247,MBD3L5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000237452,MEIOSIN,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 95.9459% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000237452,MEIOSIN,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.0305405
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 95.9459% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000237452,MEIOSIN,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,-0.0305405
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000237521,OR7E24,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000237521,OR7E24,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000237521,OR7E24,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000237524,TEX51,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,,,
True,compatible,,True,True,True,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000237524,TEX51,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.05,0.03,0.00488055
True,compatible,,True,True,True,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000237524,TEX51,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.05,0.03,0.00488055
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000237671,GAGE12C,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000237671,GAGE12C,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,ENSG00000237671,GAGE12C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000237957,CT47A5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000237957,CT47A5,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000237957,CT47A5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,False,,9,2,partial,0,0.2,0.1,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000238074,TSPY9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,,,
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,9,2,partial,0,0.2,0.1,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000238074,TSPY9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.0431507,0.0163946,0.01
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,9,2,partial,0,0.2,0.1,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000238074,TSPY9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.05,0.0163946,0.01
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,9,partial,0.7,0.6,0.7,,small intestine / enterocytes - Gradient: Ascending (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000238083,LRRC37A2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 94.3662% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 98.5294% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.7143% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 94.3662% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 94.3662% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 93.0556% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.7143% (minimum 99%, Baseline (adaptation disabled)); colon: 95.7143% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.5294% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.7143% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.7143% (minimum 99%, Baseline (adaptation disabled)); kidney: 91.7808% (minimum 99%, Baseline (adaptation disabled)); liver: 98.5294% (minimum 99%, Baseline (adaptation disabled)); lung: 94.3662% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.5294% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.1014% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 90.5405% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.0556% (minimum 97%, Baseline (adaptation disabled)); retina: 94.3662% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 91.7808% (minimum 99%, Baseline (adaptation disabled)); skin: 91.7808% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.7143% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 95.7143% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.1014% (minimum 99%, Baseline (adaptation disabled)); thymus: 90.5405% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.7808% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.3662% (minimum 97%, Baseline (adaptation disabled))",0,9,partial,0.7,0.6,0.7,,small intestine / enterocytes - Gradient: Ascending (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000238083,LRRC37A2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0445946,-0.0521918,-0.0845946
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.7143% (minimum 99%, Missing); basal ganglia: 94.3662% (minimum 99%, Missing); bone marrow: 95.7143% (minimum 97%, Supported); cerebellum: 94.3662% (minimum 97%, Supported); cerebral cortex: 93.0556% (minimum 97%, Supported); choroid plexus: 95.7143% (minimum 99%, Missing); colon: 95.7143% (minimum 97%, Missing); hippocampal formation: 95.7143% (minimum 99%, Missing); hypothalamus: 95.7143% (minimum 99%, Missing); kidney: 91.7808% (minimum 97%, Supported); lung: 94.3662% (minimum 97%, Supported); midbrain: 98.5294% (minimum 99%, Missing); pituitary gland: 90.5405% (minimum 99%, Missing); rectum: 93.0556% (minimum 97%, Missing); retina: 94.3662% (minimum 99%, Missing); skeletal muscle: 91.7808% (minimum 97%, Supported); small intestine: 95.7143% (minimum 99%, Missing); smooth muscle: 95.7143% (minimum 97%, Supported); spinal cord: 97.1014% (minimum 99%, Missing); thymus: 90.5405% (minimum 95%, Missing); tongue: 91.7808% (minimum 97%, Missing)",0,9,partial,0.7,0.6,0.7,,small intestine / enterocytes - Gradient: Ascending (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000238083,LRRC37A2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0445946,-0.0521918,-0.0845946
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000238205,MPC1L,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000238205,MPC1L,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000238205,MPC1L,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,4,0.6,0.7,"bone marrow: 4 nTPM (vital, limit 3)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000238269,PAGE2B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.2203% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,4,0.6,0.7,"bone marrow: 4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000238269,PAGE2B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0374327,0.0192086,-0.0577966
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 93.2203% (minimum 97%, Supported)",0,2,partial,4,0.6,0.7,"bone marrow: 4 nTPM (vital, limit 3)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000238269,PAGE2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0463768,0.0192086,-0.0377966
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,5,partial,49.1,33,39.4,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); spleen: 39.4 nTPM (manageable, limit 5); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 2); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 2); stomach: 29.2 nTPM (protected, limit 2); choroid plexus: 28.6 nTPM (vital, limit 1); skeletal muscle: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 2); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 2); thyroid gland: 27.6 nTPM (manageable, limit 5); skin: 27.5 nTPM (manageable, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (manageable, limit 5); thymus: 25 nTPM (manageable, limit 5); salivary gland: 24.5 nTPM (protected, limit 2); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 2); parathyroid gland: 16.9 nTPM (protected, limit 2); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000239306,RBM14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.6973% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.5007% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.1267% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.0739% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 57.5000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 47.8118% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.5263% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.4426% (minimum 99%, Baseline (adaptation disabled)); colon: 60.6103% (minimum 97%, Baseline (adaptation disabled)); duodenum: 74.1935% (minimum 99%, Baseline (adaptation disabled)); esophagus: 56.9752% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 57.5758% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.6450% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 64.9331% (minimum 99%, Baseline (adaptation disabled)); kidney: 47.0905% (minimum 99%, Baseline (adaptation disabled)); liver: 52.5240% (minimum 99%, Baseline (adaptation disabled)); lung: 62.3395% (minimum 99%, Baseline (adaptation disabled)); lymph node: 61.2903% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.3126% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.9010% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 72.1122% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.5330% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.2887% (minimum 97%, Baseline (adaptation disabled)); retina: 55.7398% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 64.0762% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 60.4426% (minimum 99%, Baseline (adaptation disabled)); skin: 61.3764% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.6944% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 74.3197% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.4383% (minimum 99%, Baseline (adaptation disabled)); spleen: 52.5872% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.9451% (minimum 97%, Baseline (adaptation disabled)); thymus: 63.6099% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 61.2903% (minimum 95%, Baseline (adaptation disabled)); tongue: 79.7445% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.7811% (minimum 97%, Baseline (adaptation disabled))",0,5,partial,49.1,33,39.4,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); spleen: 39.4 nTPM (manageable, limit 5); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 2); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 2); stomach: 29.2 nTPM (protected, limit 2); choroid plexus: 28.6 nTPM (vital, limit 1); skeletal muscle: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 2); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 2); thyroid gland: 27.6 nTPM (manageable, limit 5); skin: 27.5 nTPM (manageable, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (manageable, limit 5); thymus: 25 nTPM (manageable, limit 5); salivary gland: 24.5 nTPM (protected, limit 2); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 2); parathyroid gland: 16.9 nTPM (protected, limit 2); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000239306,RBM14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.424128,-0.400248,-0.519095
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.6973% (minimum 95%, Missing); adrenal gland: 58.5007% (minimum 99%, Missing); amygdala: 65.1267% (minimum 99%, Missing); basal ganglia: 62.0739% (minimum 99%, Missing); bone marrow: 57.5000% (minimum 99%, Missing); cerebellum: 47.8118% (minimum 99%, Missing); cerebral cortex: 60.5263% (minimum 99%, Missing); choroid plexus: 60.4426% (minimum 99%, Missing); colon: 60.6103% (minimum 97%, Missing); duodenum: 74.1935% (minimum 99%, Missing); esophagus: 56.9752% (minimum 97%, Missing); heart muscle: 57.5758% (minimum 99%, Missing); hippocampal formation: 64.6450% (minimum 99%, Missing); hypothalamus: 64.9331% (minimum 99%, Missing); kidney: 47.0905% (minimum 99%, Missing); liver: 52.5240% (minimum 99%, Missing); lung: 62.3395% (minimum 99%, Missing); lymph node: 61.2903% (minimum 97%, Missing); midbrain: 66.3126% (minimum 99%, Missing); pancreas: 56.9010% (minimum 99%, Missing); parathyroid gland: 72.1122% (minimum 97%, Missing); pituitary gland: 56.5330% (minimum 99%, Missing); rectum: 71.2887% (minimum 97%, Missing); retina: 55.7398% (minimum 99%, Missing); salivary gland: 64.0762% (minimum 97%, Missing); skeletal muscle: 60.4426% (minimum 99%, Missing); skin: 61.3764% (minimum 95%, Missing); small intestine: 60.6944% (minimum 99%, Missing); smooth muscle: 74.3197% (minimum 99%, Missing); spinal cord: 67.4383% (minimum 99%, Missing); spleen: 52.5872% (minimum 95%, Missing); stomach: 59.9451% (minimum 97%, Missing); thymus: 63.6099% (minimum 95%, Missing); thyroid gland: 61.2903% (minimum 95%, Missing); tongue: 79.7445% (minimum 97%, Missing); urinary bladder: 59.7811% (minimum 97%, Missing)",0,5,partial,49.1,33,39.4,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); spleen: 39.4 nTPM (manageable, limit 5); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 2); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 2); stomach: 29.2 nTPM (protected, limit 2); choroid plexus: 28.6 nTPM (vital, limit 1); skeletal muscle: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 2); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 2); thyroid gland: 27.6 nTPM (manageable, limit 5); skin: 27.5 nTPM (manageable, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (manageable, limit 5); thymus: 25 nTPM (manageable, limit 5); salivary gland: 24.5 nTPM (protected, limit 2); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 2); parathyroid gland: 16.9 nTPM (protected, limit 2); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 2)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000239306,RBM14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.424128,-0.400248,-0.519095
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,27.1,17.3,0.8,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 2); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000239388,ASB14,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 50.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 66.6667% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 24.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.5455% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 60.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 13.9535% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); kidney: 75.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 66.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 54.5455% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.1538% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 28.5714% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 27.2727% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 2.1661% (minimum 99%, Baseline (adaptation disabled)); skin: 42.8571% (minimum 95%, Baseline (adaptation disabled)); small intestine: 54.5455% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.5455% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 60.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 3.3520% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,27.1,17.3,0.8,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 2); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000239388,ASB14,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.521429,-0.93648,-0.968339
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 50.0000% (minimum 95%, Missing); adrenal gland: 66.6667% (minimum 99%, Missing); amygdala: 75.0000% (minimum 99%, Missing); basal ganglia: 75.0000% (minimum 99%, Missing); bone marrow: 24.0000% (minimum 99%, Missing); cerebellum: 54.5455% (minimum 99%, Missing); cerebral cortex: 60.0000% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 60.0000% (minimum 97%, Missing); heart muscle: 13.9535% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 66.6667% (minimum 99%, Missing); kidney: 75.0000% (minimum 99%, Missing); liver: 66.6667% (minimum 99%, Missing); lung: 54.5455% (minimum 99%, Missing); lymph node: 46.1538% (minimum 97%, Missing); midbrain: 66.6667% (minimum 99%, Missing); pancreas: 28.5714% (minimum 99%, Missing); pituitary gland: 60.0000% (minimum 99%, Missing); retina: 27.2727% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing); skeletal muscle: 2.1661% (minimum 99%, Missing); skin: 42.8571% (minimum 95%, Missing); small intestine: 54.5455% (minimum 99%, Missing); spinal cord: 66.6667% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 54.5455% (minimum 97%, Missing); thyroid gland: 60.0000% (minimum 95%, Missing); tongue: 3.3520% (minimum 97%, Missing); urinary bladder: 60.0000% (minimum 97%, Missing)",0,80,unavailable,27.1,17.3,0.8,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 2); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000239388,ASB14,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.521429,-0.93648,-0.968339
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,1.8,3.4,0.2,"parathyroid gland: 3.4 nTPM (protected, limit 2); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland,ENSG00000239389,PCDHA13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 71.4286% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 33.3333% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 31.2500% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 21.7391% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 26.3158% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 31.2500% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 38.4615% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 71.4286% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.3333% (minimum 97%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 45.4545% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 12.8205% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 55.5556% (minimum 99%, Baseline (adaptation disabled)); retina: 31.2500% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); smooth muscle: 83.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 55.5556% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 71.4286% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.8,3.4,0.2,"parathyroid gland: 3.4 nTPM (protected, limit 2); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland,ENSG00000239389,PCDHA13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.235714,-0.841795,-0.772609
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 71.4286% (minimum 95%, Missing); adrenal gland: 83.3333% (minimum 99%, Missing); amygdala: 33.3333% (minimum 99%, Missing); basal ganglia: 31.2500% (minimum 99%, Missing); cerebellum: 21.7391% (minimum 99%, Missing); cerebral cortex: 26.3158% (minimum 99%, Missing); hippocampal formation: 31.2500% (minimum 99%, Missing); hypothalamus: 38.4615% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 71.4286% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 83.3333% (minimum 97%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 45.4545% (minimum 99%, Missing); parathyroid gland: 12.8205% (minimum 97%, Missing); pituitary gland: 55.5556% (minimum 99%, Missing); retina: 31.2500% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); smooth muscle: 83.3333% (minimum 99%, Missing); spinal cord: 55.5556% (minimum 99%, Missing); thyroid gland: 71.4286% (minimum 95%, Missing)",0,80,unavailable,1.8,3.4,0.2,"parathyroid gland: 3.4 nTPM (protected, limit 2); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland,ENSG00000239389,PCDHA13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.235714,-0.841795,-0.772609
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000239590,OR1J4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000239590,OR1J4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000239590,OR1J4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,4,partial,0.1,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000239605,STPG4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0.1,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000239605,STPG4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0430556,0.0162069,0.00305556
True,compatible,,True,True,True,,0,4,partial,0.1,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000239605,STPG4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019;Wang 2016;da Silva 2017,0.0430556,0.03,0.00305556
False,unresolved,incomplete_routine_rna,True,True,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000239620,PRR20G,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,,,
False,unresolved,incomplete_routine_rna,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000239620,PRR20G,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000239620,PRR20G,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,2,partial,30.1,9.6,14.5,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (manageable, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 9.8 nTPM (manageable, limit 5); basal ganglia: 9.7 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); esophagus: 6.5 nTPM (protected, limit 2); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); lymph node: 2.5 nTPM (protected, limit 2); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000239704,CDRT4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.2581% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 56.8773% (minimum 99%, Baseline (adaptation disabled)); amygdala: 68.6099% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.2000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 83.6066% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 57.9545% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 66.2338% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 50.4950% (minimum 99%, Baseline (adaptation disabled)); colon: 69.5455% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.7097% (minimum 99%, Baseline (adaptation disabled)); esophagus: 70.1835% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.7027% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 67.1053% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 60.2362% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.0734% (minimum 99%, Baseline (adaptation disabled)); liver: 70.1835% (minimum 99%, Baseline (adaptation disabled)); lung: 75.3695% (minimum 99%, Baseline (adaptation disabled)); lymph node: 85.9551% (minimum 97%, Baseline (adaptation disabled)); midbrain: 69.2308% (minimum 99%, Baseline (adaptation disabled)); pancreas: 55.8394% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.8354% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 33.7004% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.4749% (minimum 97%, Baseline (adaptation disabled)); retina: 72.1698% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 61.4458% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.6250% (minimum 99%, Baseline (adaptation disabled)); skin: 60.9562% (minimum 95%, Baseline (adaptation disabled)); small intestine: 67.1053% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.2927% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.8333% (minimum 99%, Baseline (adaptation disabled)); spleen: 59.5331% (minimum 95%, Baseline (adaptation disabled)); stomach: 68.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 89.4737% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 51.3423% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 73.9130% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,30.1,9.6,14.5,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (manageable, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 9.8 nTPM (manageable, limit 5); basal ganglia: 9.7 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); esophagus: 6.5 nTPM (protected, limit 2); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); lymph node: 2.5 nTPM (protected, limit 2); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000239704,CDRT4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.436577,-0.355542,-0.652996
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 82.2581% (minimum 95%, Uncertain); adrenal gland: 56.8773% (minimum 99%, Missing); amygdala: 68.6099% (minimum 99%, Missing); basal ganglia: 61.2000% (minimum 99%, Missing); bone marrow: 83.6066% (minimum 99%, Uncertain); cerebellum: 57.9545% (minimum 99%, Missing); cerebral cortex: 66.2338% (minimum 99%, Uncertain); choroid plexus: 50.4950% (minimum 99%, Missing); colon: 69.5455% (minimum 97%, Missing); duodenum: 98.7097% (minimum 99%, Missing); esophagus: 70.1835% (minimum 97%, Uncertain); heart muscle: 82.7027% (minimum 99%, Missing); hippocampal formation: 67.1053% (minimum 99%, Missing); hypothalamus: 60.2362% (minimum 99%, Missing); kidney: 59.0734% (minimum 99%, Uncertain); liver: 70.1835% (minimum 99%, Missing); lung: 75.3695% (minimum 99%, Missing); lymph node: 85.9551% (minimum 97%, Uncertain); midbrain: 69.2308% (minimum 99%, Missing); pancreas: 55.8394% (minimum 99%, Uncertain); parathyroid gland: 96.8354% (minimum 97%, Missing); pituitary gland: 33.7004% (minimum 99%, Missing); rectum: 85.4749% (minimum 97%, Missing); retina: 72.1698% (minimum 99%, Missing); salivary gland: 61.4458% (minimum 97%, Missing); skeletal muscle: 95.6250% (minimum 99%, Missing); skin: 60.9562% (minimum 95%, Uncertain); small intestine: 67.1053% (minimum 99%, Missing); smooth muscle: 93.2927% (minimum 99%, Missing); spinal cord: 70.8333% (minimum 99%, Missing); spleen: 59.5331% (minimum 95%, Uncertain); stomach: 68.0000% (minimum 97%, Missing); thymus: 89.4737% (minimum 95%, Missing); thyroid gland: 51.3423% (minimum 95%, Missing); urinary bladder: 73.9130% (minimum 97%, Missing)",0,2,partial,30.1,9.6,14.5,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (manageable, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 9.8 nTPM (manageable, limit 5); basal ganglia: 9.7 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 2); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 2); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 2); esophagus: 6.5 nTPM (protected, limit 2); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 2); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); rectum: 2.6 nTPM (protected, limit 2); lymph node: 2.5 nTPM (protected, limit 2); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,ENSG00000239704,CDRT4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.436577,-0.355542,-0.652996
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,4,partial,31.7,31.3,9.9,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 2); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 2); colon: 12.6 nTPM (protected, limit 2); cerebellum: 12.5 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 2); urinary bladder: 10.6 nTPM (protected, limit 2); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 2); parathyroid gland: 9.3 nTPM (protected, limit 4); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 8.8 nTPM (protected, limit 2); salivary gland: 8.7 nTPM (protected, limit 2); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thyroid gland: 7.9 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000239789,MRPS17,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.2885% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 46.7480% (minimum 99%, Baseline (adaptation disabled)); amygdala: 46.5587% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 45.4545% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 53.7383% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 47.9167% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 41.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.5263% (minimum 99%, Baseline (adaptation disabled)); colon: 47.7178% (minimum 97%, Baseline (adaptation disabled)); duodenum: 57.2139% (minimum 99%, Baseline (adaptation disabled)); esophagus: 46.7480% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 37.2168% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 46.3710% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 47.9167% (minimum 99%, Baseline (adaptation disabled)); kidney: 41.3669% (minimum 99%, Baseline (adaptation disabled)); liver: 34.7432% (minimum 99%, Baseline (adaptation disabled)); lung: 63.1868% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.6502% (minimum 97%, Baseline (adaptation disabled)); midbrain: 54.2453% (minimum 99%, Baseline (adaptation disabled)); pancreas: 46.5587% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.2885% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 58.6735% (minimum 99%, Baseline (adaptation disabled)); rectum: 54.7619% (minimum 97%, Baseline (adaptation disabled)); retina: 68.0473% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 56.9307% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 26.6204% (minimum 99%, Baseline (adaptation disabled)); skin: 58.9744% (minimum 95%, Baseline (adaptation disabled)); small intestine: 56.3725% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.0976% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 59.8958% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.7383% (minimum 95%, Baseline (adaptation disabled)); stomach: 50.6608% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.3725% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.2784% (minimum 95%, Baseline (adaptation disabled)); tongue: 26.8692% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 52.0362% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,31.7,31.3,9.9,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 2); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 2); colon: 12.6 nTPM (protected, limit 2); cerebellum: 12.5 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 2); urinary bladder: 10.6 nTPM (protected, limit 2); spleen: 9.9 nTPM (manageable, limit 5); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 2); parathyroid gland: 9.3 nTPM (protected, limit 2); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 8.8 nTPM (protected, limit 2); salivary gland: 8.7 nTPM (protected, limit 2); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thyroid gland: 7.9 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000239789,MRPS17,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.412617,-0.701308,-0.723796
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.2885% (minimum 90%, Approved); adrenal gland: 46.7480% (minimum 99%, Missing); amygdala: 46.5587% (minimum 99%, Missing); basal ganglia: 45.4545% (minimum 99%, Missing); bone marrow: 53.7383% (minimum 99%, Missing); cerebellum: 47.9167% (minimum 99%, Missing); cerebral cortex: 41.6667% (minimum 99%, Missing); choroid plexus: 60.5263% (minimum 99%, Missing); colon: 47.7178% (minimum 97%, Missing); duodenum: 57.2139% (minimum 99%, Missing); esophagus: 46.7480% (minimum 97%, Missing); heart muscle: 37.2168% (minimum 99%, Missing); hippocampal formation: 46.3710% (minimum 99%, Missing); hypothalamus: 47.9167% (minimum 99%, Missing); kidney: 41.3669% (minimum 99%, Missing); liver: 34.7432% (minimum 99%, Missing); lung: 63.1868% (minimum 99%, Missing); lymph node: 56.6502% (minimum 97%, Missing); midbrain: 54.2453% (minimum 99%, Missing); pancreas: 46.5587% (minimum 99%, Missing); parathyroid gland: 55.2885% (minimum 95%, Approved); pituitary gland: 58.6735% (minimum 99%, Missing); rectum: 54.7619% (minimum 97%, Missing); retina: 68.0473% (minimum 99%, Missing); salivary gland: 56.9307% (minimum 97%, Missing); skeletal muscle: 26.6204% (minimum 99%, Missing); skin: 58.9744% (minimum 95%, Missing); small intestine: 56.3725% (minimum 99%, Missing); smooth muscle: 56.0976% (minimum 99%, Missing); spinal cord: 59.8958% (minimum 99%, Missing); spleen: 53.7383% (minimum 90%, Approved); stomach: 50.6608% (minimum 97%, Missing); thymus: 56.3725% (minimum 95%, Missing); thyroid gland: 59.2784% (minimum 95%, Missing); tongue: 26.8692% (minimum 97%, Missing); urinary bladder: 52.0362% (minimum 97%, Missing)",0,4,partial,31.7,31.3,9.9,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 2); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 2); colon: 12.6 nTPM (protected, limit 2); cerebellum: 12.5 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 2); urinary bladder: 10.6 nTPM (protected, limit 2); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 2); parathyroid gland: 9.3 nTPM (protected, limit 4); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 8.8 nTPM (protected, limit 2); salivary gland: 8.7 nTPM (protected, limit 2); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thyroid gland: 7.9 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000239789,MRPS17,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.386275,-0.701308,-0.723796
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000239810,PRAMEF11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000239810,PRAMEF11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000239810,PRAMEF11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,31.7,"skin: 31.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000239886,KRTAP9-2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"skin: 0.3145% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,31.7,"skin: 31.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000239886,KRTAP9-2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.946855,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"skin: 0.3145% (minimum 95%, Missing)",0,80,unavailable,0,0,31.7,"skin: 31.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000239886,KRTAP9-2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.946855,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,21.4,9.4,5.1,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 2); stomach: 8.4 nTPM (protected, limit 2); salivary gland: 8.3 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); esophagus: 4 nTPM (protected, limit 2); parathyroid gland: 3.9 nTPM (protected, limit 2); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000239887,C1orf226,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.4433% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 45.9302% (minimum 99%, Baseline (adaptation disabled)); amygdala: 81.4433% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.2917% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.7980% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.8611% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 76.6990% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 71.1712% (minimum 99%, Baseline (adaptation disabled)); colon: 46.7456% (minimum 97%, Baseline (adaptation disabled)); duodenum: 59.3985% (minimum 99%, Baseline (adaptation disabled)); esophagus: 66.3866% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.5357% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.2381% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.2982% (minimum 99%, Baseline (adaptation disabled)); kidney: 41.7989% (minimum 99%, Baseline (adaptation disabled)); liver: 26.9625% (minimum 99%, Baseline (adaptation disabled)); lung: 76.6990% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.3415% (minimum 97%, Baseline (adaptation disabled)); midbrain: 73.8318% (minimum 99%, Baseline (adaptation disabled)); pancreas: 69.2982% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.9492% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 45.1429% (minimum 99%, Baseline (adaptation disabled)); rectum: 45.6647% (minimum 97%, Baseline (adaptation disabled)); retina: 53.7415% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 48.7654% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.9412% (minimum 99%, Baseline (adaptation disabled)); skin: 60.7692% (minimum 95%, Baseline (adaptation disabled)); small intestine: 50.6410% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 76.6990% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.5357% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.9412% (minimum 95%, Baseline (adaptation disabled)); stomach: 48.4663% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 91.8605% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.9412% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.6990% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,21.4,9.4,5.1,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 2); stomach: 8.4 nTPM (protected, limit 2); salivary gland: 8.3 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); esophagus: 4 nTPM (protected, limit 2); parathyroid gland: 3.9 nTPM (protected, limit 2); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000239887,C1orf226,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.342308,-0.513353,-0.720375
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 81.4433% (minimum 90%, Approved); adrenal gland: 45.9302% (minimum 99%, Missing); amygdala: 81.4433% (minimum 99%, Missing); basal ganglia: 82.2917% (minimum 99%, Missing); bone marrow: 79.7980% (minimum 99%, Missing); cerebellum: 54.8611% (minimum 99%, Missing); cerebral cortex: 76.6990% (minimum 99%, Missing); choroid plexus: 71.1712% (minimum 99%, Missing); colon: 46.7456% (minimum 97%, Missing); duodenum: 59.3985% (minimum 99%, Missing); esophagus: 66.3866% (minimum 97%, Missing); heart muscle: 70.5357% (minimum 99%, Missing); hippocampal formation: 75.2381% (minimum 99%, Missing); hypothalamus: 69.2982% (minimum 99%, Missing); kidney: 41.7989% (minimum 99%, Missing); liver: 26.9625% (minimum 99%, Missing); lung: 76.6990% (minimum 99%, Missing); lymph node: 96.3415% (minimum 97%, Missing); midbrain: 73.8318% (minimum 99%, Missing); pancreas: 69.2982% (minimum 99%, Missing); parathyroid gland: 66.9492% (minimum 97%, Missing); pituitary gland: 45.1429% (minimum 99%, Missing); rectum: 45.6647% (minimum 97%, Missing); retina: 53.7415% (minimum 99%, Missing); salivary gland: 48.7654% (minimum 97%, Missing); skeletal muscle: 92.9412% (minimum 99%, Missing); skin: 60.7692% (minimum 95%, Missing); small intestine: 50.6410% (minimum 99%, Missing); smooth muscle: 76.6990% (minimum 99%, Missing); spinal cord: 70.5357% (minimum 99%, Missing); spleen: 92.9412% (minimum 95%, Missing); stomach: 48.4663% (minimum 97%, Missing); thyroid gland: 91.8605% (minimum 95%, Missing); tongue: 92.9412% (minimum 97%, Missing); urinary bladder: 76.6990% (minimum 97%, Missing)",0,2,partial,21.4,9.4,5.1,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 2); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 2); stomach: 8.4 nTPM (protected, limit 2); salivary gland: 8.3 nTPM (protected, limit 2); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); esophagus: 4 nTPM (protected, limit 2); parathyroid gland: 3.9 nTPM (protected, limit 2); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); urinary bladder: 2.4 nTPM (protected, limit 2); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000239887,C1orf226,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.342308,-0.513353,-0.720375
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,1.8,1.4,1.5,"retina: 1.5 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240021,TEX35,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 98.4549% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.7941% (minimum 99%, Baseline (adaptation disabled)); retina: 98.7091% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.8,1.4,1.5,"bone marrow: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240021,TEX35,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0370912,0.0179414,-0.00545064
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.7091% (minimum 99%, Missing)",0,3,partial,1.8,1.4,1.5,"retina: 1.5 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240021,TEX35,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0482594,0.0273913,-0.00290878
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10,6.2,0.7,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 2); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240204,SMKR1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.0032% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 92.3136% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6853% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.7908% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9292% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.0800% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.2340% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2011% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2011% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.0911% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.3175% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,10,6.2,0.7,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 2); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240204,SMKR1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.0442053,-0.0190895,-0.066864
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.0032% (minimum 99%, Missing); basal ganglia: 92.3136% (minimum 99%, Missing); cerebellum: 98.6853% (minimum 99%, Missing); cerebral cortex: 94.7908% (minimum 99%, Missing); choroid plexus: 98.9292% (minimum 99%, Missing); hippocampal formation: 96.0800% (minimum 99%, Missing); hypothalamus: 96.2340% (minimum 99%, Missing); midbrain: 98.2011% (minimum 99%, Missing); pancreas: 98.2011% (minimum 99%, Missing); parathyroid gland: 95.0911% (minimum 97%, Missing); pituitary gland: 95.3175% (minimum 99%, Missing)",0,80,unavailable,10,6.2,0.7,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 2); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240204,SMKR1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.0442053,-0.0190895,-0.066864
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,12,partial,100.5,8.6,15.6,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 6); bone marrow: 7.7 nTPM (vital, limit 6); adrenal gland: 7.4 nTPM (vital, limit 6); colon: 7.4 nTPM (protected, limit 2); smooth muscle: 6.1 nTPM (vital, limit 6); spinal cord: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); hypothalamus: 3.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),93,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240303,ACAD11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 38.0952% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 56.4706% (minimum 99%, Baseline (adaptation disabled)); amygdala: 73.2824% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.5652% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.4913% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 69.5652% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 70.0730% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 17.2043% (minimum 99%, Baseline (adaptation disabled)); colon: 56.4706% (minimum 97%, Baseline (adaptation disabled)); duodenum: 36.6412% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.1111% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 39.1837% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 73.2824% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 13.3891% (minimum 99%, Baseline (adaptation disabled)); liver: 8.7193% (minimum 99%, Baseline (adaptation disabled)); lung: 63.1579% (minimum 99%, Baseline (adaptation disabled)); lymph node: 75.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.5882% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.8571% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.7473% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 50.2618% (minimum 99%, Baseline (adaptation disabled)); rectum: 74.4186% (minimum 97%, Baseline (adaptation disabled)); retina: 45.9330% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.5762% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 70.0730% (minimum 99%, Baseline (adaptation disabled)); skin: 61.1465% (minimum 95%, Baseline (adaptation disabled)); small intestine: 38.5542% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.1465% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.1329% (minimum 99%, Baseline (adaptation disabled)); spleen: 69.5652% (minimum 95%, Baseline (adaptation disabled)); stomach: 67.6056% (minimum 97%, Baseline (adaptation disabled)); thymus: 68.0851% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 60.7595% (minimum 95%, Baseline (adaptation disabled)); tongue: 83.4783% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 64.4295% (minimum 97%, Baseline (adaptation disabled))",0,12,partial,100.5,8.6,15.6,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); adipose tissue: 15.6 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); parathyroid gland: 8.6 nTPM (protected, limit 2); pancreas: 7.9 nTPM (vital, limit 1); bone marrow: 7.7 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 2); adrenal gland: 7.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6.1 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 2); urinary bladder: 5.3 nTPM (protected, limit 2); spinal cord: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 2); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); lymph node: 3.2 nTPM (protected, limit 2); hypothalamus: 3.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),93,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240303,ACAD11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.569048,-0.442527,-0.902807
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 38.0952% (minimum 60%, Enhanced); adrenal gland: 56.4706% (minimum 95%, Enhanced); amygdala: 73.2824% (minimum 99%, Missing); basal ganglia: 69.5652% (minimum 99%, Missing); bone marrow: 55.4913% (minimum 95%, Enhanced); cerebellum: 69.5652% (minimum 99%, Missing); cerebral cortex: 70.0730% (minimum 99%, Missing); choroid plexus: 17.2043% (minimum 99%, Missing); colon: 56.4706% (minimum 97%, Missing); duodenum: 36.6412% (minimum 99%, Missing); esophagus: 71.1111% (minimum 80%, Enhanced); heart muscle: 39.1837% (minimum 99%, Missing); hippocampal formation: 73.2824% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 13.3891% (minimum 99%, Missing); liver: 8.7193% (minimum 99%, Missing); lung: 63.1579% (minimum 95%, Enhanced); lymph node: 75.0000% (minimum 80%, Enhanced); midbrain: 70.5882% (minimum 99%, Missing); pancreas: 54.8571% (minimum 95%, Enhanced); parathyroid gland: 52.7473% (minimum 80%, Enhanced); pituitary gland: 50.2618% (minimum 99%, Missing); rectum: 74.4186% (minimum 97%, Missing); retina: 45.9330% (minimum 99%, Missing); salivary gland: 63.5762% (minimum 80%, Enhanced); skeletal muscle: 70.0730% (minimum 99%, Missing); small intestine: 38.5542% (minimum 99%, Missing); smooth muscle: 61.1465% (minimum 95%, Enhanced); spinal cord: 67.1329% (minimum 99%, Missing); stomach: 67.6056% (minimum 97%, Missing); thymus: 68.0851% (minimum 95%, Missing); tongue: 83.4783% (minimum 97%, Missing); urinary bladder: 64.4295% (minimum 80%, Enhanced)",0,12,partial,100.5,8.6,15.6,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 6); bone marrow: 7.7 nTPM (vital, limit 6); adrenal gland: 7.4 nTPM (vital, limit 6); colon: 7.4 nTPM (protected, limit 2); smooth muscle: 6.1 nTPM (vital, limit 6); spinal cord: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 2); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 2); hypothalamus: 3.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),93,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240303,ACAD11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.269149,-0.405294,-0.902807
False,excluded,rna_above_tissue_ceiling;incomplete_routine_rna,True,True,False,,9,80,unavailable,2.2,1.7,2.3,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240445,FOXO3B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.3571% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.8182% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 67.1642% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.5385% (minimum 99%, Baseline (adaptation disabled)); colon: 81.8182% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.9474% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 83.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 93.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 72.5806% (minimum 97%, Baseline (adaptation disabled)); pancreas: 84.9057% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); rectum: 84.9057% (minimum 97%, Baseline (adaptation disabled)); retina: 72.5806% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.3571% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.7500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.7705% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.3571% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.8182% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.1765% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 81.8182% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.3333% (minimum 97%, Baseline (adaptation disabled))",9,80,unavailable,2.2,1.7,2.3,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240445,FOXO3B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.288235,-0.244194,-0.318358
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"adipose tissue: 83.3333% (minimum 95%, Missing); adrenal gland: 80.3571% (minimum 99%, Missing); bone marrow: 81.8182% (minimum 99%, Missing); cerebral cortex: 67.1642% (minimum 99%, Missing); choroid plexus: 86.5385% (minimum 99%, Missing); colon: 81.8182% (minimum 97%, Missing); duodenum: 83.3333% (minimum 99%, Missing); esophagus: 78.9474% (minimum 97%, Missing); heart muscle: 75.0000% (minimum 99%, Missing); kidney: 83.3333% (minimum 99%, Missing); liver: 93.7500% (minimum 99%, Missing); lung: 83.3333% (minimum 99%, Missing); lymph node: 72.5806% (minimum 97%, Missing); pancreas: 84.9057% (minimum 99%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); rectum: 84.9057% (minimum 97%, Missing); retina: 72.5806% (minimum 99%, Missing); salivary gland: 83.3333% (minimum 97%, Missing); skeletal muscle: 80.3571% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 93.7500% (minimum 99%, Missing); smooth muscle: 73.7705% (minimum 99%, Missing); spleen: 80.3571% (minimum 95%, Missing); stomach: 81.8182% (minimum 97%, Missing); thymus: 66.1765% (minimum 95%, Missing); thyroid gland: 81.8182% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 83.3333% (minimum 97%, Missing)",9,80,unavailable,2.2,1.7,2.3,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240445,FOXO3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.288235,-0.244194,-0.318358
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.4,5.2,0.9,"colon: 5.2 nTPM (protected, limit 2); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240563,L1TD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.3913% (minimum 99%, Baseline (adaptation disabled)); colon: 68.2927% (minimum 97%, Baseline (adaptation disabled)); kidney: 97.3913% (minimum 99%, Baseline (adaptation disabled)); lung: 88.8889% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.3226% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 96.5517% (minimum 97%, Baseline (adaptation disabled)); small intestine: 97.3913% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.3913% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.5620% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.4,5.2,0.9,"colon: 5.2 nTPM (protected, limit 2); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240563,L1TD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.0243802,-0.287073,-0.101111
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.3913% (minimum 99%, Missing); colon: 68.2927% (minimum 97%, Missing); kidney: 97.3913% (minimum 99%, Missing); lung: 88.8889% (minimum 99%, Missing); rectum: 90.3226% (minimum 97%, Missing); salivary gland: 96.5517% (minimum 97%, Missing); small intestine: 97.3913% (minimum 99%, Missing); smooth muscle: 97.3913% (minimum 99%, Missing); spleen: 92.5620% (minimum 95%, Missing)",0,80,unavailable,1.4,5.2,0.9,"colon: 5.2 nTPM (protected, limit 2); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240563,L1TD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Jamin 2021;Chang 2019;Wang 2016;Bruggeman 2018,-0.0243802,-0.287073,-0.101111
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,50.4,31.2,22.1,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 2); thymus: 22.1 nTPM (manageable, limit 5); esophagus: 21.5 nTPM (protected, limit 2); colon: 20.9 nTPM (protected, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 2); skin: 19.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); adipose tissue: 18.1 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); urinary bladder: 17.7 nTPM (protected, limit 2); rectum: 16.3 nTPM (protected, limit 2); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); salivary gland: 14.4 nTPM (protected, limit 2); thyroid gland: 14.4 nTPM (manageable, limit 5); stomach: 14.4 nTPM (protected, limit 2); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000240682,ISY1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0609% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.5607% (minimum 99%, Baseline (adaptation disabled)); amygdala: 67.1924% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 66.5625% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 29.7071% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 64.7416% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 62.4633% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 67.4051% (minimum 99%, Baseline (adaptation disabled)); colon: 50.4739% (minimum 97%, Baseline (adaptation disabled)); duodenum: 58.8398% (minimum 99%, Baseline (adaptation disabled)); esophagus: 49.7664% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 50.8353% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 68.2692% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.8344% (minimum 99%, Baseline (adaptation disabled)); kidney: 59.3315% (minimum 99%, Baseline (adaptation disabled)); liver: 66.7712% (minimum 99%, Baseline (adaptation disabled)); lung: 60.8571% (minimum 99%, Baseline (adaptation disabled)); lymph node: 40.5714% (minimum 97%, Baseline (adaptation disabled)); midbrain: 66.9811% (minimum 99%, Baseline (adaptation disabled)); pancreas: 58.1967% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 66.3551% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 71.4765% (minimum 99%, Baseline (adaptation disabled)); rectum: 56.6489% (minimum 97%, Baseline (adaptation disabled)); retina: 67.8344% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 59.6639% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 38.7978% (minimum 99%, Baseline (adaptation disabled)); skin: 51.9512% (minimum 95%, Baseline (adaptation disabled)); small intestine: 57.5676% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 52.2059% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 66.3551% (minimum 99%, Baseline (adaptation disabled)); spleen: 54.4757% (minimum 95%, Baseline (adaptation disabled)); stomach: 59.6639% (minimum 97%, Baseline (adaptation disabled)); thymus: 49.0783% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 59.6639% (minimum 95%, Baseline (adaptation disabled)); tongue: 51.0791% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.6154% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,50.4,31.2,22.1,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 2); thymus: 22.1 nTPM (manageable, limit 5); esophagus: 21.5 nTPM (protected, limit 2); colon: 20.9 nTPM (protected, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 2); skin: 19.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); adipose tissue: 18.1 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); urinary bladder: 17.7 nTPM (protected, limit 2); rectum: 16.3 nTPM (protected, limit 2); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); salivary gland: 14.4 nTPM (protected, limit 2); thyroid gland: 14.4 nTPM (manageable, limit 5); stomach: 14.4 nTPM (protected, limit 2); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000240682,ISY1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.459217,-0.564286,-0.692929
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0609% (minimum 95%, Missing); adrenal gland: 61.5607% (minimum 99%, Missing); amygdala: 67.1924% (minimum 99%, Missing); basal ganglia: 66.5625% (minimum 99%, Missing); bone marrow: 29.7071% (minimum 99%, Missing); cerebellum: 64.7416% (minimum 99%, Missing); cerebral cortex: 62.4633% (minimum 99%, Missing); choroid plexus: 67.4051% (minimum 99%, Missing); colon: 50.4739% (minimum 97%, Missing); duodenum: 58.8398% (minimum 99%, Missing); esophagus: 49.7664% (minimum 97%, Missing); heart muscle: 50.8353% (minimum 99%, Missing); hippocampal formation: 68.2692% (minimum 99%, Missing); hypothalamus: 67.8344% (minimum 99%, Missing); kidney: 59.3315% (minimum 99%, Missing); liver: 66.7712% (minimum 99%, Missing); lung: 60.8571% (minimum 99%, Missing); lymph node: 40.5714% (minimum 97%, Missing); midbrain: 66.9811% (minimum 99%, Missing); pancreas: 58.1967% (minimum 99%, Missing); parathyroid gland: 66.3551% (minimum 97%, Missing); pituitary gland: 71.4765% (minimum 99%, Missing); rectum: 56.6489% (minimum 97%, Missing); retina: 67.8344% (minimum 99%, Missing); salivary gland: 59.6639% (minimum 97%, Missing); skeletal muscle: 38.7978% (minimum 99%, Missing); skin: 51.9512% (minimum 95%, Missing); small intestine: 57.5676% (minimum 99%, Missing); smooth muscle: 52.2059% (minimum 99%, Missing); spinal cord: 66.3551% (minimum 99%, Missing); spleen: 54.4757% (minimum 95%, Missing); stomach: 59.6639% (minimum 97%, Missing); thymus: 49.0783% (minimum 95%, Missing); thyroid gland: 59.6639% (minimum 95%, Missing); tongue: 51.0791% (minimum 97%, Missing); urinary bladder: 54.6154% (minimum 97%, Missing)",0,4,partial,50.4,31.2,22.1,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 2); thymus: 22.1 nTPM (manageable, limit 5); esophagus: 21.5 nTPM (protected, limit 2); colon: 20.9 nTPM (protected, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 2); skin: 19.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); adipose tissue: 18.1 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); urinary bladder: 17.7 nTPM (protected, limit 2); rectum: 16.3 nTPM (protected, limit 2); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); salivary gland: 14.4 nTPM (protected, limit 2); thyroid gland: 14.4 nTPM (manageable, limit 5); stomach: 14.4 nTPM (protected, limit 2); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 2); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000240682,ISY1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.459217,-0.564286,-0.692929
True,compatible,,True,True,False,,0,4,partial,0.4,0.1,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000240720,LRRD1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.9452% (minimum 99%, Baseline (adaptation disabled)); retina: 97.2789% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,0.4,0.1,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000240720,LRRD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0294521,0.0230556,-0.0172109
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 97.2789% (minimum 99%, Missing)",0,4,partial,0.4,0.1,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000240720,LRRD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.0172109
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.3,4.6,5.1,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); esophagus: 4.6 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240747,KRBOX1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7111% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.0102% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.3615% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.8677% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.3615% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8169% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.1604% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.3112% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.3615% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.3151% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2106% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.0102% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.1604% (minimum 99%, Baseline (adaptation disabled)); retina: 98.6140% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.3644% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.6614% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,5.3,4.6,5.1,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); esophagus: 4.6 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240747,KRBOX1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0241379,0.00661413,-0.016849
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.7111% (minimum 99%, Missing); amygdala: 98.0102% (minimum 99%, Missing); basal ganglia: 98.3615% (minimum 99%, Missing); cerebellum: 98.8677% (minimum 99%, Missing); cerebral cortex: 98.3615% (minimum 99%, Missing); choroid plexus: 98.8169% (minimum 99%, Missing); heart muscle: 98.1604% (minimum 99%, Missing); hippocampal formation: 98.3112% (minimum 99%, Missing); hypothalamus: 98.3615% (minimum 99%, Missing); kidney: 97.3151% (minimum 99%, Missing); midbrain: 98.2106% (minimum 99%, Missing); pancreas: 98.0102% (minimum 99%, Missing); pituitary gland: 98.1604% (minimum 99%, Missing); retina: 98.6140% (minimum 99%, Missing); smooth muscle: 97.3644% (minimum 99%, Missing); spinal cord: 97.6614% (minimum 99%, Missing)",0,80,unavailable,5.3,4.6,5.1,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); esophagus: 4.6 nTPM (protected, limit 2); adrenal gland: 4.5 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 2); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 2); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); stomach: 2.5 nTPM (protected, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); rectum: 2.2 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000240747,KRBOX1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0241379,0.00661413,-0.016849
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000241128,OR14A2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000241128,OR14A2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000241128,OR14A2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000241149,ZNF722,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 94.4444% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000241149,ZNF722,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021;Loriot 2025,0.05,0.03,-0.0455556
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 94.4444% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000241149,ZNF722,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021;Loriot 2025,0.05,0.03,-0.0455556
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.8,0.5,7.3,"skin: 7.3 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000241233,KRTAP5-8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 87.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.6842% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 82.3529% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.6842% (minimum 99%, Baseline (adaptation disabled)); colon: 93.3333% (minimum 97%, Baseline (adaptation disabled)); esophagus: 93.3333% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 82.3529% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.7778% (minimum 99%, Baseline (adaptation disabled)); kidney: 19.4444% (minimum 99%, Baseline (adaptation disabled)); liver: 87.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 93.3333% (minimum 99%, Baseline (adaptation disabled)); midbrain: 87.5000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.3333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 93.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.3333% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.3333% (minimum 99%, Baseline (adaptation disabled)); skin: 16.0920% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.5000% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.3333% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 73.6842% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,5.8,0.5,7.3,"skin: 7.3 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000241233,KRTAP5-8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.78908,-0.233158,-0.795556
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.3333% (minimum 95%, Missing); adrenal gland: 93.3333% (minimum 99%, Missing); amygdala: 87.5000% (minimum 99%, Missing); basal ganglia: 73.6842% (minimum 99%, Missing); cerebellum: 82.3529% (minimum 99%, Missing); cerebral cortex: 73.6842% (minimum 99%, Missing); colon: 93.3333% (minimum 97%, Missing); esophagus: 93.3333% (minimum 97%, Missing); hippocampal formation: 82.3529% (minimum 99%, Missing); hypothalamus: 77.7778% (minimum 99%, Missing); kidney: 19.4444% (minimum 99%, Missing); liver: 87.5000% (minimum 99%, Missing); lung: 93.3333% (minimum 99%, Missing); midbrain: 87.5000% (minimum 99%, Missing); pancreas: 93.3333% (minimum 99%, Missing); pituitary gland: 93.3333% (minimum 99%, Missing); salivary gland: 93.3333% (minimum 97%, Missing); skeletal muscle: 93.3333% (minimum 99%, Missing); skin: 16.0920% (minimum 95%, Missing); small intestine: 93.3333% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 93.3333% (minimum 95%, Missing); urinary bladder: 73.6842% (minimum 97%, Missing)",0,80,unavailable,5.8,0.5,7.3,"skin: 7.3 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000241233,KRTAP5-8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.78908,-0.233158,-0.795556
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,36.7,20.4,19.4,"bone marrow: 36.7 nTPM (vital, limit 2); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 2); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (manageable, limit 5); esophagus: 19.3 nTPM (protected, limit 4); rectum: 18.9 nTPM (protected, limit 2); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 2); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 2); spleen: 16.9 nTPM (manageable, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 2); urinary bladder: 15.9 nTPM (protected, limit 2); skin: 15.6 nTPM (manageable, limit 5); salivary gland: 15.6 nTPM (protected, limit 2); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 2); adipose tissue: 13 nTPM (manageable, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000241258,CRCP,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 53.6278% (minimum 99%, Baseline (adaptation disabled)); amygdala: 56.1056% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.7377% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 31.6574% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.7975% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 48.8506% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.6667% (minimum 99%, Baseline (adaptation disabled)); colon: 48.9914% (minimum 97%, Baseline (adaptation disabled)); duodenum: 51.2048% (minimum 99%, Baseline (adaptation disabled)); esophagus: 46.8320% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 50.2959% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.2391% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.9683% (minimum 99%, Baseline (adaptation disabled)); kidney: 51.6717% (minimum 99%, Baseline (adaptation disabled)); liver: 39.7196% (minimum 99%, Baseline (adaptation disabled)); lung: 54.6624% (minimum 99%, Baseline (adaptation disabled)); lymph node: 51.6717% (minimum 97%, Baseline (adaptation disabled)); midbrain: 55.0162% (minimum 99%, Baseline (adaptation disabled)); pancreas: 46.0705% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 45.4545% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 61.1511% (minimum 99%, Baseline (adaptation disabled)); rectum: 47.3538% (minimum 97%, Baseline (adaptation disabled)); retina: 55.1948% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 52.1472% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 54.4872% (minimum 99%, Baseline (adaptation disabled)); skin: 52.1472% (minimum 95%, Baseline (adaptation disabled)); small intestine: 54.3131% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 49.2754% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 55.3746% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.1475% (minimum 95%, Baseline (adaptation disabled)); stomach: 49.5627% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.7975% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 46.7033% (minimum 95%, Baseline (adaptation disabled)); tongue: 56.6667% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.6717% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,36.7,20.4,19.4,"bone marrow: 36.7 nTPM (vital, limit 1); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 2); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (manageable, limit 5); esophagus: 19.3 nTPM (protected, limit 2); rectum: 18.9 nTPM (protected, limit 2); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 2); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 2); spleen: 16.9 nTPM (manageable, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 2); urinary bladder: 15.9 nTPM (protected, limit 2); skin: 15.6 nTPM (manageable, limit 5); salivary gland: 15.6 nTPM (protected, limit 2); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 2); adipose tissue: 13 nTPM (manageable, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000241258,CRCP,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.482967,-0.515455,-0.673426
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.6667% (minimum 95%, Missing); adrenal gland: 53.6278% (minimum 99%, Missing); amygdala: 56.1056% (minimum 99%, Missing); basal ganglia: 55.7377% (minimum 99%, Missing); bone marrow: 31.6574% (minimum 98%, Approved); cerebellum: 53.7975% (minimum 99%, Missing); cerebral cortex: 48.8506% (minimum 99%, Missing); choroid plexus: 66.6667% (minimum 99%, Missing); colon: 48.9914% (minimum 97%, Missing); duodenum: 51.2048% (minimum 99%, Missing); esophagus: 46.8320% (minimum 95%, Approved); heart muscle: 50.2959% (minimum 99%, Missing); hippocampal formation: 57.2391% (minimum 99%, Missing); hypothalamus: 53.9683% (minimum 99%, Missing); kidney: 51.6717% (minimum 99%, Missing); liver: 39.7196% (minimum 99%, Missing); lung: 54.6624% (minimum 99%, Missing); lymph node: 51.6717% (minimum 97%, Missing); midbrain: 55.0162% (minimum 99%, Missing); pancreas: 46.0705% (minimum 99%, Missing); parathyroid gland: 45.4545% (minimum 97%, Missing); pituitary gland: 61.1511% (minimum 99%, Missing); rectum: 47.3538% (minimum 97%, Missing); retina: 55.1948% (minimum 99%, Missing); salivary gland: 52.1472% (minimum 97%, Missing); skeletal muscle: 54.4872% (minimum 99%, Missing); skin: 52.1472% (minimum 95%, Missing); small intestine: 54.3131% (minimum 99%, Missing); smooth muscle: 49.2754% (minimum 99%, Missing); spinal cord: 55.3746% (minimum 99%, Missing); spleen: 50.1475% (minimum 95%, Missing); stomach: 49.5627% (minimum 97%, Missing); thymus: 53.7975% (minimum 95%, Missing); thyroid gland: 46.7033% (minimum 95%, Missing); tongue: 56.6667% (minimum 97%, Missing); urinary bladder: 51.6717% (minimum 97%, Missing)",0,3,partial,36.7,20.4,19.4,"bone marrow: 36.7 nTPM (vital, limit 2); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 2); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (manageable, limit 5); esophagus: 19.3 nTPM (protected, limit 4); rectum: 18.9 nTPM (protected, limit 2); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 2); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 2); spleen: 16.9 nTPM (manageable, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 2); urinary bladder: 15.9 nTPM (protected, limit 2); skin: 15.6 nTPM (manageable, limit 5); salivary gland: 15.6 nTPM (protected, limit 2); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 2); adipose tissue: 13 nTPM (manageable, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,ENSG00000241258,CRCP,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.482967,-0.515455,-0.663426
True,compatible,,True,True,False,,0,2,partial,0,0,0.2,,,54,not_established,not_triggered,,,ENSG00000241476,SSX2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Seager 2024;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0,0,0.2,,,54,not_established,not_triggered,,,ENSG00000241476,SSX2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Seager 2024;Loriot 2025;da Silva 2017,0.0378049,0.03,0.01
True,compatible,,True,True,True,,0,2,partial,0,0,0.2,,,54,not_established,not_triggered,,,ENSG00000241476,SSX2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Chang 2019;Wang 2016;Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,3,partial,18.4,1.1,1,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242220,TCP10L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.8024% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.6547% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.1169% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.4095% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8024% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.7531% (minimum 99%, Baseline (adaptation disabled)); liver: 91.4972% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,18.4,1.1,1,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242220,TCP10L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0449749,0.0244751,-0.0750277
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 98.8024% (minimum 99%, Missing); basal ganglia: 98.6547% (minimum 99%, Missing); hippocampal formation: 98.8024% (minimum 99%, Missing); hypothalamus: 98.7531% (minimum 99%, Missing); liver: 91.4972% (minimum 99%, Missing)",0,3,partial,18.4,1.1,1,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242220,TCP10L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Gong 2021,0.0479839,0.0244751,-0.0750277
True,compatible,,True,True,False,,0,80,unavailable,0.9,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000242221,PSG2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,,True,True,True,,0,80,unavailable,0.9,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000242221,PSG2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0482759,0.0291372,0.00612903
True,compatible,,True,True,True,,0,80,unavailable,0.9,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,ENSG00000242221,PSG2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0482759,0.0291372,0.00612903
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000242362,CT47A2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000242362,CT47A2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000242362,CT47A2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,ENSG00000242389,RBMY1E,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,ENSG00000242389,RBMY1E,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,ENSG00000242389,RBMY1E,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,8.4,2,"colon: 8.4 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000242441,GTF2A1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 97.9798% (minimum 99%, Baseline (adaptation disabled)); colon: 87.3874% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.6441% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.1450% (minimum 99%, Baseline (adaptation disabled)); lung: 98.1450% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.9796% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.3244% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.9796% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.8115% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.8814% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 93.4189% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,1.6,8.4,2,"colon: 8.4 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000242441,GTF2A1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0167774,-0.0961261,-0.0167559
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 97.9798% (minimum 99%, Missing); colon: 87.3874% (minimum 97%, Missing); heart muscle: 98.6441% (minimum 99%, Missing); kidney: 98.1450% (minimum 99%, Missing); lung: 98.1450% (minimum 99%, Missing); skeletal muscle: 98.9796% (minimum 99%, Missing); small intestine: 97.3244% (minimum 99%, Missing); smooth muscle: 98.9796% (minimum 99%, Missing); spinal cord: 98.8115% (minimum 99%, Missing); stomach: 95.8814% (minimum 97%, Missing); urinary bladder: 93.4189% (minimum 97%, Missing)",0,80,unavailable,1.6,8.4,2,"colon: 8.4 nTPM (protected, limit 2); urinary bladder: 4.1 nTPM (protected, limit 2); stomach: 2.5 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,ENSG00000242441,GTF2A1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0167774,-0.0961261,-0.0167559
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.8,1.8,0.6,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242715,CCDC169,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 95.3566% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2906% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.9673% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.9673% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.9673% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.9646% (minimum 97%, Baseline (adaptation disabled)); retina: 95.8333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.4576% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.8,1.8,0.6,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242715,CCDC169,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,0.039673,-0.000354132,-0.0364345
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 95.3566% (minimum 99%, Missing); cerebral cortex: 98.2906% (minimum 99%, Missing); choroid plexus: 98.9673% (minimum 99%, Missing); heart muscle: 98.9673% (minimum 99%, Missing); kidney: 98.9673% (minimum 99%, Missing); parathyroid gland: 96.9646% (minimum 97%, Missing); retina: 95.8333% (minimum 99%, Missing); smooth muscle: 97.4576% (minimum 99%, Missing)",0,80,unavailable,2.8,1.8,0.6,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242715,CCDC169,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019;Wang 2016;Loriot 2025,0.039673,-0.000354132,-0.0364345
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3,2.2,2.8,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242852,ZNF709,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7107% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 94.3038% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.8537% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.6279% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.7532% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.1808% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.4110% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 94.3038% (minimum 99%, Baseline (adaptation disabled)); colon: 94.3038% (minimum 97%, Baseline (adaptation disabled)); esophagus: 96.1290% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 93.7107% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.8537% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.6905% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.3030% (minimum 99%, Baseline (adaptation disabled)); liver: 97.3856% (minimum 99%, Baseline (adaptation disabled)); lung: 94.9045% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.9045% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.9753% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.1250% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.1345% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.3030% (minimum 99%, Baseline (adaptation disabled)); retina: 83.2402% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.7107% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.3038% (minimum 99%, Baseline (adaptation disabled)); small intestine: 94.9045% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 93.7107% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.7107% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.5466% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.9045% (minimum 97%, Baseline (adaptation disabled)); thymus: 87.6471% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 84.1808% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.3038% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.3038% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3,2.2,2.8,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242852,ZNF709,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.108192,-0.098655,-0.157598
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.7107% (minimum 95%, Missing); adrenal gland: 94.3038% (minimum 99%, Missing); amygdala: 90.8537% (minimum 99%, Missing); basal ganglia: 86.6279% (minimum 99%, Missing); bone marrow: 96.7532% (minimum 99%, Missing); cerebellum: 84.1808% (minimum 99%, Missing); cerebral cortex: 91.4110% (minimum 99%, Missing); choroid plexus: 94.3038% (minimum 99%, Missing); colon: 94.3038% (minimum 97%, Missing); esophagus: 96.1290% (minimum 97%, Missing); heart muscle: 93.7107% (minimum 99%, Missing); hippocampal formation: 90.8537% (minimum 99%, Missing); hypothalamus: 88.6905% (minimum 99%, Missing); kidney: 90.3030% (minimum 99%, Missing); liver: 97.3856% (minimum 99%, Missing); lung: 94.9045% (minimum 99%, Missing); lymph node: 94.9045% (minimum 97%, Missing); midbrain: 91.9753% (minimum 99%, Missing); pancreas: 93.1250% (minimum 99%, Missing); parathyroid gland: 87.1345% (minimum 97%, Missing); pituitary gland: 90.3030% (minimum 99%, Missing); retina: 83.2402% (minimum 99%, Missing); salivary gland: 93.7107% (minimum 97%, Missing); skeletal muscle: 94.3038% (minimum 99%, Missing); small intestine: 94.9045% (minimum 99%, Missing); smooth muscle: 93.7107% (minimum 99%, Missing); spinal cord: 93.7107% (minimum 99%, Missing); spleen: 92.5466% (minimum 95%, Missing); stomach: 94.9045% (minimum 97%, Missing); thymus: 87.6471% (minimum 95%, Missing); thyroid gland: 84.1808% (minimum 95%, Missing); tongue: 94.3038% (minimum 97%, Missing); urinary bladder: 94.3038% (minimum 97%, Missing)",0,80,unavailable,3,2.2,2.8,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242852,ZNF709,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.108192,-0.098655,-0.157598
True,compatible,,True,True,False,,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,ENSG00000242875,RBMY1B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,ENSG00000242875,RBMY1B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,ENSG00000242875,RBMY1B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Wang 2016;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.7,1.2,1,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242950,ERVW-1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Jamin 2021;Gong 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6916% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.6916% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.6522% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8764% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6916% (minimum 99%, Baseline (adaptation disabled)); retina: 88.7395% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.8764% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8764% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,6.7,1.2,1,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242950,ERVW-1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Jamin 2021;Gong 2021;Loriot 2025,0.0314126,0.00777778,-0.102605
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.6916% (minimum 99%, Missing); bone marrow: 98.6916% (minimum 99%, Missing); choroid plexus: 95.6522% (minimum 99%, Missing); lung: 98.8764% (minimum 99%, Missing); pancreas: 98.6916% (minimum 99%, Missing); retina: 88.7395% (minimum 99%, Missing); skeletal muscle: 98.8764% (minimum 99%, Missing); small intestine: 98.8764% (minimum 99%, Missing)",0,80,unavailable,6.7,1.2,1,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000242950,ERVW-1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Jamin 2021;Gong 2021;Loriot 2025,0.0314126,0.00777778,-0.102605
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000243073,PRAMEF4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000243073,PRAMEF4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000243073,PRAMEF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,1,partial,0.5,0,0.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000243130,PSG11,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.5,0,0.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000243130,PSG11,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0480545,0.03,0.00034749
True,compatible,,True,True,True,,0,1,partial,0.5,0,0.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000243130,PSG11,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,2,partial,1,53.8,3.2,"parathyroid gland: 53.8 nTPM (protected, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; tonsil,ENSG00000243137,PSG4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 72.1676% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,1,53.8,3.2,"parathyroid gland: 53.8 nTPM (protected, limit 2)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; tonsil,ENSG00000243137,PSG4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0275753,-0.248324,0.00288256
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 72.1676% (minimum 90%, Supported)",0,2,partial,1,53.8,3.2,"parathyroid gland: 53.8 nTPM (protected, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; tonsil,ENSG00000243137,PSG4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,-0.178324,0.00928367
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.3,0.1,0.5,"lung: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000243543,WFDC6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,1.3,0.1,0.5,"lung: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000243543,WFDC6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0477043,0.02954,0.00405306
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,80,unavailable,1.3,0.1,0.5,"lung: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000243543,WFDC6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0477043,0.02954,0.00405306
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,11,9.5,10.3,"skeletal muscle: 11 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 4); choroid plexus: 8.9 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); rectum: 7.7 nTPM (protected, limit 2); smooth muscle: 7.2 nTPM (vital, limit 2); parathyroid gland: 7 nTPM (protected, limit 4); adrenal gland: 6.8 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 2); retina: 6.7 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 2); stomach: 5.8 nTPM (protected, limit 2); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 2); cerebellum: 5 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000243667,DNAAF10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.8972% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.6429% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.2222% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 81.2500% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.7282% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 75.3623% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 63.6735% (minimum 99%, Baseline (adaptation disabled)); colon: 72.5581% (minimum 97%, Baseline (adaptation disabled)); duodenum: 71.8894% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.6429% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.1975% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 76.8473% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.6411% (minimum 99%, Baseline (adaptation disabled)); liver: 75.7282% (minimum 99%, Baseline (adaptation disabled)); lung: 73.5849% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.1514% (minimum 97%, Baseline (adaptation disabled)); midbrain: 79.5918% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.7879% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 69.0265% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 77.2277% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.9528% (minimum 97%, Baseline (adaptation disabled)); retina: 69.9552% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 71.8894% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.6466% (minimum 99%, Baseline (adaptation disabled)); skin: 60.2317% (minimum 95%, Baseline (adaptation disabled)); small intestine: 75.3623% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 68.4211% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 78.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 66.1017% (minimum 95%, Baseline (adaptation disabled)); stomach: 72.8972% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.3830% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.8228% (minimum 95%, Baseline (adaptation disabled)); tongue: 64.1975% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 76.4706% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,11,9.5,10.3,"skeletal muscle: 11 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 2); choroid plexus: 8.9 nTPM (vital, limit 1); heart muscle: 8.7 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 2); thyroid gland: 8.1 nTPM (manageable, limit 5); spleen: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); rectum: 7.7 nTPM (protected, limit 2); smooth muscle: 7.2 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 2); esophagus: 6.8 nTPM (protected, limit 2); adrenal gland: 6.8 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 2); stomach: 5.8 nTPM (protected, limit 2); adipose tissue: 5.8 nTPM (manageable, limit 5); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000243667,DNAAF10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.347683,-0.348486,-0.403534
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 72.8972% (minimum 90%, Approved); adrenal gland: 69.6429% (minimum 99%, Missing); amygdala: 78.0000% (minimum 99%, Missing); basal ganglia: 72.2222% (minimum 99%, Missing); bone marrow: 81.2500% (minimum 99%, Missing); cerebellum: 75.7282% (minimum 99%, Missing); cerebral cortex: 75.3623% (minimum 99%, Missing); choroid plexus: 63.6735% (minimum 99%, Missing); colon: 72.5581% (minimum 97%, Missing); duodenum: 71.8894% (minimum 99%, Missing); esophagus: 69.6429% (minimum 97%, Missing); heart muscle: 64.1975% (minimum 99%, Missing); hippocampal formation: 75.0000% (minimum 99%, Missing); hypothalamus: 76.8473% (minimum 99%, Missing); kidney: 74.6411% (minimum 99%, Missing); liver: 75.7282% (minimum 98%, Approved); lung: 73.5849% (minimum 99%, Missing); lymph node: 62.1514% (minimum 95%, Approved); midbrain: 79.5918% (minimum 99%, Missing); pancreas: 78.7879% (minimum 99%, Missing); parathyroid gland: 69.0265% (minimum 95%, Approved); pituitary gland: 77.2277% (minimum 99%, Missing); rectum: 66.9528% (minimum 97%, Missing); retina: 69.9552% (minimum 99%, Missing); salivary gland: 71.8894% (minimum 97%, Missing); skeletal muscle: 58.6466% (minimum 99%, Missing); skin: 60.2317% (minimum 95%, Missing); small intestine: 75.3623% (minimum 99%, Missing); smooth muscle: 68.4211% (minimum 98%, Approved); spinal cord: 78.0000% (minimum 99%, Missing); spleen: 66.1017% (minimum 90%, Approved); stomach: 72.8972% (minimum 97%, Missing); thymus: 66.3830% (minimum 95%, Missing); thyroid gland: 65.8228% (minimum 95%, Missing); tongue: 64.1975% (minimum 97%, Missing); urinary bladder: 76.4706% (minimum 97%, Missing)",0,2,partial,11,9.5,10.3,"skeletal muscle: 11 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 4); choroid plexus: 8.9 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); rectum: 7.7 nTPM (protected, limit 2); smooth muscle: 7.2 nTPM (vital, limit 2); parathyroid gland: 7 nTPM (protected, limit 4); adrenal gland: 6.8 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 2); retina: 6.7 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 2); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 2); stomach: 5.8 nTPM (protected, limit 2); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 2); cerebellum: 5 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000243667,DNAAF10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.347683,-0.328486,-0.403534
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,5,partial,13.6,0.2,1,"choroid plexus: 13.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,ENSG00000243710,CFAP57,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.7806% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.8000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.8448% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 62.5344% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.0328% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.2764% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.1864% (minimum 99%, Baseline (adaptation disabled)); liver: 89.3701% (minimum 99%, Baseline (adaptation disabled)); lung: 90.4382% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.4249% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 91.9028% (minimum 99%, Baseline (adaptation disabled)); retina: 94.1909% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.6957% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,13.6,0.2,1,"choroid plexus: 13.6 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,ENSG00000243710,CFAP57,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.00780591,0.0212664,-0.364656
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 95.7806% (minimum 99%, Missing); basal ganglia: 90.8000% (minimum 99%, Missing); choroid plexus: 62.5344% (minimum 99%, Missing); hippocampal formation: 93.0328% (minimum 99%, Missing); hypothalamus: 92.2764% (minimum 99%, Missing); liver: 89.3701% (minimum 95%, Enhanced); lung: 90.4382% (minimum 99%, Missing); pituitary gland: 91.9028% (minimum 99%, Missing); retina: 94.1909% (minimum 99%, Missing); spinal cord: 98.6957% (minimum 99%, Missing)",0,5,partial,13.6,0.2,1,"choroid plexus: 13.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,ENSG00000243710,CFAP57,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.0412664,0.03,-0.364656
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000243729,OR5V1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000243729,OR5V1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000243729,OR5V1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,1.2,0,0.1,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000243978,RTL9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.7013% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.2025% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.3563% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.8272% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.4359% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 93.8272% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.4359% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 86.3636% (minimum 99%, Baseline (adaptation disabled)); liver: 98.7013% (minimum 99%, Baseline (adaptation disabled)); midbrain: 91.5663% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.4359% (minimum 99%, Baseline (adaptation disabled)); retina: 97.4359% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.7013% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.7013% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7013% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,1.2,0,0.1,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000243978,RTL9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.037013,0.03,-0.126364
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 96.2025% (minimum 99%, Missing); basal ganglia: 87.3563% (minimum 99%, Missing); cerebellum: 93.8272% (minimum 95%, Enhanced); heart muscle: 93.8272% (minimum 95%, Enhanced); hippocampal formation: 97.4359% (minimum 99%, Missing); hypothalamus: 86.3636% (minimum 99%, Missing); midbrain: 91.5663% (minimum 99%, Missing); pituitary gland: 97.4359% (minimum 99%, Missing); retina: 97.4359% (minimum 99%, Missing); spinal cord: 98.7013% (minimum 99%, Missing)",0,4,partial,1.2,0,0.1,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000243978,RTL9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,0.05,0.03,-0.126364
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0.2,1.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000244057,LCE3C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"esophagus: 50.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 10.5263% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0.2,1.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000244057,LCE3C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.844737,-0.47,0.01
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"esophagus: 50.0000% (minimum 97%, Missing); skin: 10.5263% (minimum 95%, Missing)",0,80,unavailable,0,0.2,1.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,ENSG00000244057,LCE3C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.844737,-0.47,0.01
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,3.4,2.4,3.8,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000244219,TMEM225B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 98.5936% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.9412% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.1577% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.8864% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.3026% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.0854% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.0132% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.5110% (minimum 99%, Baseline (adaptation disabled)); lung: 98.9599% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.8692% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.9412% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.3026% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.4,2.4,3.8,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000244219,TMEM225B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0222628,0.0123009,-0.0148902
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 98.5936% (minimum 99%, Missing); amygdala: 97.9412% (minimum 99%, Missing); basal ganglia: 98.1577% (minimum 99%, Missing); cerebellum: 98.8864% (minimum 99%, Missing); cerebral cortex: 98.3026% (minimum 99%, Missing); hippocampal formation: 98.0854% (minimum 99%, Missing); hypothalamus: 98.0132% (minimum 99%, Missing); kidney: 97.5110% (minimum 99%, Missing); lung: 98.9599% (minimum 99%, Missing); midbrain: 97.8692% (minimum 99%, Missing); pituitary gland: 97.9412% (minimum 99%, Missing); spinal cord: 98.3026% (minimum 99%, Missing)",0,80,unavailable,3.4,2.4,3.8,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); parathyroid gland: 2.4 nTPM (protected, limit 2); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000244219,TMEM225B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0222628,0.0123009,-0.0148902
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,False,,9,5,partial,0,0.2,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000244234,GMCL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,9,5,partial,0,0.2,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000244234,GMCL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,0.0193617,0.01
False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,9,5,partial,0,0.2,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000244234,GMCL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,0.0193617,0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000244395,RBMY1D,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000244395,RBMY1D,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000244395,RBMY1D,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.6,7.2,0.5,"parathyroid gland: 7.2 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,ENSG00000244476,ERVFRD-1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8950% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.6226% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.6226% (minimum 99%, Baseline (adaptation disabled)); lung: 98.3516% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 83.2558% (minimum 97%, Baseline (adaptation disabled)); small intestine: 98.6226% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,7.2,0.5,"parathyroid gland: 7.2 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,ENSG00000244476,ERVFRD-1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0362259,-0.137442,-0.00648352
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.8950% (minimum 99%, Missing); duodenum: 98.6226% (minimum 99%, Missing); kidney: 98.6226% (minimum 99%, Missing); lung: 98.3516% (minimum 99%, Missing); parathyroid gland: 83.2558% (minimum 97%, Missing); small intestine: 98.6226% (minimum 99%, Missing)",0,80,unavailable,0.6,7.2,0.5,"parathyroid gland: 7.2 nTPM (protected, limit 2)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,ENSG00000244476,ERVFRD-1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0362259,-0.137442,-0.00648352
True,compatible,,True,True,False,,0,5,partial,0.8,0.1,0,,,51,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000244588,RAD21L1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 92.8571% (minimum 99%, Baseline (adaptation disabled))",0,5,partial,0.8,0.1,0,,,51,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000244588,RAD21L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.0204762,-0.0614286
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 92.8571% (minimum 99%, Missing)",0,5,partial,0.8,0.1,0,,,51,not_established,required,lymphatic_and_immune_function_review,lymph node,ENSG00000244588,RAD21L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.0614286
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000244624,KRTAP20-1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"skin: 20.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0,0,0.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000244624,KRTAP20-1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.75,0.03,0.01
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"skin: 20.0000% (minimum 95%, Missing)",0,80,unavailable,0,0,0.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000244624,KRTAP20-1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.75,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,84.8,69.2,61.9,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 2); tongue: 68.2 nTPM (protected, limit 2); colon: 67.1 nTPM (protected, limit 2); lymph node: 66.8 nTPM (protected, limit 2); urinary bladder: 65.3 nTPM (protected, limit 2); pancreas: 62.7 nTPM (vital, limit 1); skin: 61.9 nTPM (manageable, limit 5); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 2); thymus: 59.2 nTPM (manageable, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 2); adipose tissue: 59.1 nTPM (manageable, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 2); salivary gland: 54 nTPM (protected, limit 2); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); spleen: 50.5 nTPM (manageable, limit 5); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (manageable, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000244687,UBE2V1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.0292% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 54.0928% (minimum 99%, Baseline (adaptation disabled)); amygdala: 51.1981% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.4605% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 55.8849% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 54.6928% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 45.0140% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 45.4288% (minimum 99%, Baseline (adaptation disabled)); colon: 48.8567% (minimum 97%, Baseline (adaptation disabled)); duodenum: 53.0190% (minimum 99%, Baseline (adaptation disabled)); esophagus: 48.0870% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.6103% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.6907% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.6851% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.4612% (minimum 99%, Baseline (adaptation disabled)); liver: 45.8184% (minimum 99%, Baseline (adaptation disabled)); lung: 53.1069% (minimum 99%, Baseline (adaptation disabled)); lymph node: 48.9687% (minimum 97%, Baseline (adaptation disabled)); midbrain: 56.0315% (minimum 99%, Baseline (adaptation disabled)); pancreas: 50.5521% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 52.0292% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 65.7436% (minimum 99%, Baseline (adaptation disabled)); rectum: 51.9449% (minimum 97%, Baseline (adaptation disabled)); retina: 58.3789% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 54.2760% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 43.0490% (minimum 99%, Baseline (adaptation disabled)); skin: 50.8730% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.9825% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 47.5167% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.1000% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.9337% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.1385% (minimum 97%, Baseline (adaptation disabled)); thymus: 51.9870% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.9778% (minimum 95%, Baseline (adaptation disabled)); tongue: 48.4505% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 49.5363% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,84.8,69.2,61.9,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 2); tongue: 68.2 nTPM (protected, limit 2); colon: 67.1 nTPM (protected, limit 2); lymph node: 66.8 nTPM (protected, limit 2); urinary bladder: 65.3 nTPM (protected, limit 2); pancreas: 62.7 nTPM (vital, limit 1); skin: 61.9 nTPM (manageable, limit 5); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 2); thymus: 59.2 nTPM (manageable, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 2); adipose tissue: 59.1 nTPM (manageable, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 2); salivary gland: 54 nTPM (protected, limit 2); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); spleen: 50.5 nTPM (manageable, limit 5); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (manageable, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000244687,UBE2V1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.44127,-0.48913,-0.55951
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.0292% (minimum 95%, Missing); adrenal gland: 54.0928% (minimum 99%, Missing); amygdala: 51.1981% (minimum 99%, Missing); basal ganglia: 54.4605% (minimum 99%, Missing); bone marrow: 55.8849% (minimum 99%, Missing); cerebellum: 54.6928% (minimum 99%, Missing); cerebral cortex: 45.0140% (minimum 99%, Missing); choroid plexus: 45.4288% (minimum 99%, Missing); colon: 48.8567% (minimum 97%, Missing); duodenum: 53.0190% (minimum 99%, Missing); esophagus: 48.0870% (minimum 97%, Missing); heart muscle: 51.6103% (minimum 99%, Missing); hippocampal formation: 55.6907% (minimum 99%, Missing); hypothalamus: 53.6851% (minimum 99%, Missing); kidney: 53.4612% (minimum 99%, Missing); liver: 45.8184% (minimum 99%, Missing); lung: 53.1069% (minimum 99%, Missing); lymph node: 48.9687% (minimum 97%, Missing); midbrain: 56.0315% (minimum 99%, Missing); pancreas: 50.5521% (minimum 99%, Missing); parathyroid gland: 52.0292% (minimum 97%, Missing); pituitary gland: 65.7436% (minimum 99%, Missing); rectum: 51.9449% (minimum 97%, Missing); retina: 58.3789% (minimum 99%, Missing); salivary gland: 54.2760% (minimum 97%, Missing); skeletal muscle: 43.0490% (minimum 99%, Missing); skin: 50.8730% (minimum 95%, Missing); small intestine: 55.9825% (minimum 99%, Missing); smooth muscle: 47.5167% (minimum 99%, Missing); spinal cord: 64.1000% (minimum 99%, Missing); spleen: 55.9337% (minimum 95%, Missing); stomach: 54.1385% (minimum 97%, Missing); thymus: 51.9870% (minimum 95%, Missing); thyroid gland: 56.9778% (minimum 95%, Missing); tongue: 48.4505% (minimum 97%, Missing); urinary bladder: 49.5363% (minimum 97%, Missing)",0,80,unavailable,84.8,69.2,61.9,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 2); tongue: 68.2 nTPM (protected, limit 2); colon: 67.1 nTPM (protected, limit 2); lymph node: 66.8 nTPM (protected, limit 2); urinary bladder: 65.3 nTPM (protected, limit 2); pancreas: 62.7 nTPM (vital, limit 1); skin: 61.9 nTPM (manageable, limit 5); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 2); thymus: 59.2 nTPM (manageable, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 2); adipose tissue: 59.1 nTPM (manageable, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 2); salivary gland: 54 nTPM (protected, limit 2); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); spleen: 50.5 nTPM (manageable, limit 5); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (manageable, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000244687,UBE2V1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.44127,-0.48913,-0.55951
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,4,partial,32,23.1,17.5,"skeletal muscle: 32 nTPM (vital, limit 6); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 2); lymph node: 20.9 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 2); cerebral cortex: 17.7 nTPM (vital, limit 1); skin: 17.5 nTPM (manageable, limit 5); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); colon: 16 nTPM (protected, limit 2); salivary gland: 15.4 nTPM (protected, limit 2); urinary bladder: 15 nTPM (protected, limit 2); duodenum: 14.8 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); thymus: 14.1 nTPM (manageable, limit 5); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); small intestine: 12.8 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); rectum: 11.2 nTPM (protected, limit 2); thyroid gland: 11.2 nTPM (manageable, limit 5); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (manageable, limit 5); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000247077,PGAM5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5263% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 48.4940% (minimum 99%, Baseline (adaptation disabled)); amygdala: 58.1227% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.5455% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.2355% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 52.7869% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 47.6331% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.9194% (minimum 99%, Baseline (adaptation disabled)); colon: 50.1558% (minimum 97%, Baseline (adaptation disabled)); duodenum: 52.1036% (minimum 99%, Baseline (adaptation disabled)); esophagus: 41.0714% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 45.3521% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 52.7869% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 57.5000% (minimum 99%, Baseline (adaptation disabled)); kidney: 53.8462% (minimum 99%, Baseline (adaptation disabled)); liver: 36.3431% (minimum 99%, Baseline (adaptation disabled)); lung: 64.1434% (minimum 99%, Baseline (adaptation disabled)); lymph node: 43.5135% (minimum 97%, Baseline (adaptation disabled)); midbrain: 62.4031% (minimum 99%, Baseline (adaptation disabled)); pancreas: 39.0777% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 61.2167% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.6459% (minimum 99%, Baseline (adaptation disabled)); rectum: 58.9744% (minimum 97%, Baseline (adaptation disabled)); retina: 73.5160% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 51.1111% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 33.4719% (minimum 99%, Baseline (adaptation disabled)); skin: 47.9167% (minimum 95%, Baseline (adaptation disabled)); small intestine: 55.7093% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.2996% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 67.6471% (minimum 99%, Baseline (adaptation disabled)); spleen: 55.7093% (minimum 95%, Baseline (adaptation disabled)); stomach: 54.7619% (minimum 97%, Baseline (adaptation disabled)); thymus: 53.3113% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.9744% (minimum 95%, Baseline (adaptation disabled)); tongue: 47.0760% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 51.7685% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,32,23.1,17.5,"skeletal muscle: 32 nTPM (vital, limit 1); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 2); lymph node: 20.9 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 2); cerebral cortex: 17.7 nTPM (vital, limit 1); skin: 17.5 nTPM (manageable, limit 5); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); colon: 16 nTPM (protected, limit 2); salivary gland: 15.4 nTPM (protected, limit 2); urinary bladder: 15 nTPM (protected, limit 2); duodenum: 14.8 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); thymus: 14.1 nTPM (manageable, limit 5); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); spleen: 12.8 nTPM (manageable, limit 5); small intestine: 12.8 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); rectum: 11.2 nTPM (protected, limit 2); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (manageable, limit 5); parathyroid gland: 10.2 nTPM (protected, limit 2); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000247077,PGAM5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.470833,-0.559286,-0.655281
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5263% (minimum 95%, Missing); adrenal gland: 48.4940% (minimum 99%, Missing); amygdala: 58.1227% (minimum 99%, Missing); basal ganglia: 58.5455% (minimum 99%, Missing); bone marrow: 49.2355% (minimum 99%, Missing); cerebellum: 52.7869% (minimum 99%, Missing); cerebral cortex: 47.6331% (minimum 99%, Missing); choroid plexus: 64.9194% (minimum 99%, Missing); colon: 50.1558% (minimum 97%, Missing); duodenum: 52.1036% (minimum 99%, Missing); esophagus: 41.0714% (minimum 97%, Missing); heart muscle: 45.3521% (minimum 99%, Missing); hippocampal formation: 52.7869% (minimum 99%, Missing); hypothalamus: 57.5000% (minimum 99%, Missing); kidney: 53.8462% (minimum 99%, Missing); liver: 36.3431% (minimum 99%, Missing); lung: 64.1434% (minimum 99%, Missing); lymph node: 43.5135% (minimum 97%, Missing); midbrain: 62.4031% (minimum 99%, Missing); pancreas: 39.0777% (minimum 99%, Missing); parathyroid gland: 61.2167% (minimum 80%, Enhanced); pituitary gland: 62.6459% (minimum 99%, Missing); rectum: 58.9744% (minimum 97%, Missing); retina: 73.5160% (minimum 99%, Missing); salivary gland: 51.1111% (minimum 97%, Missing); skeletal muscle: 33.4719% (minimum 95%, Enhanced); skin: 47.9167% (minimum 95%, Missing); small intestine: 55.7093% (minimum 99%, Missing); smooth muscle: 60.2996% (minimum 99%, Missing); spinal cord: 67.6471% (minimum 99%, Missing); spleen: 55.7093% (minimum 95%, Missing); stomach: 54.7619% (minimum 97%, Missing); thymus: 53.3113% (minimum 95%, Missing); thyroid gland: 58.9744% (minimum 95%, Missing); tongue: 47.0760% (minimum 97%, Missing); urinary bladder: 51.7685% (minimum 97%, Missing)",0,4,partial,32,23.1,17.5,"skeletal muscle: 32 nTPM (vital, limit 6); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 2); lymph node: 20.9 nTPM (protected, limit 2); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 2); cerebral cortex: 17.7 nTPM (vital, limit 1); skin: 17.5 nTPM (manageable, limit 5); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); colon: 16 nTPM (protected, limit 2); salivary gland: 15.4 nTPM (protected, limit 2); urinary bladder: 15 nTPM (protected, limit 2); duodenum: 14.8 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); thymus: 14.1 nTPM (manageable, limit 5); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 2); small intestine: 12.8 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); rectum: 11.2 nTPM (protected, limit 2); thyroid gland: 11.2 nTPM (manageable, limit 5); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (manageable, limit 5); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000247077,PGAM5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.470833,-0.559286,-0.626569
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,3.5,5.4,5.1,"parathyroid gland: 5.4 nTPM (protected, limit 2); thyroid gland: 5.1 nTPM (manageable, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000247746,USP51,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.1520% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.9880% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.2151% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.9754% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.7936% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.8919% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.8333% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.0239% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.1831% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.2663% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.2432% (minimum 99%, Baseline (adaptation disabled)); liver: 97.7733% (minimum 99%, Baseline (adaptation disabled)); lung: 96.9880% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.3790% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.7733% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.9441% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.1831% (minimum 99%, Baseline (adaptation disabled)); retina: 94.1520% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5714% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.4072% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.5758% (minimum 99%, Baseline (adaptation disabled)); thyroid gland: 90.4494% (minimum 95%, Baseline (adaptation disabled))",0,6,partial,3.5,5.4,5.1,"parathyroid gland: 5.4 nTPM (protected, limit 2); thyroid gland: 5.1 nTPM (manageable, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000247746,USP51,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0455056,-0.0705587,-0.0575676
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 94.1520% (minimum 99%, Missing); amygdala: 96.9880% (minimum 99%, Missing); basal ganglia: 96.2151% (minimum 99%, Missing); bone marrow: 98.9754% (minimum 99%, Missing); cerebellum: 96.7936% (minimum 99%, Missing); cerebral cortex: 94.8919% (minimum 99%, Missing); choroid plexus: 95.8333% (minimum 99%, Missing); heart muscle: 96.0239% (minimum 99%, Missing); hippocampal formation: 97.1831% (minimum 99%, Missing); hypothalamus: 95.2663% (minimum 99%, Missing); kidney: 93.2432% (minimum 99%, Missing); liver: 97.7733% (minimum 99%, Uncertain); lung: 96.9880% (minimum 99%, Missing); midbrain: 97.3790% (minimum 99%, Missing); pancreas: 97.7733% (minimum 99%, Missing); parathyroid gland: 89.9441% (minimum 97%, Missing); pituitary gland: 97.1831% (minimum 99%, Missing); retina: 94.1520% (minimum 99%, Missing); small intestine: 98.5714% (minimum 99%, Missing); smooth muscle: 96.4072% (minimum 99%, Uncertain); spinal cord: 97.5758% (minimum 99%, Missing); thyroid gland: 90.4494% (minimum 95%, Missing)",0,6,partial,3.5,5.4,5.1,"parathyroid gland: 5.4 nTPM (protected, limit 2); thyroid gland: 5.1 nTPM (manageable, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000247746,USP51,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0455056,-0.0705587,-0.0575676
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,107.3,117.2,40.4,"tongue: 117.2 nTPM (protected, limit 2); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 2); parathyroid gland: 54.4 nTPM (protected, limit 2); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 2); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (manageable, limit 5); salivary gland: 39.7 nTPM (protected, limit 2); adipose tissue: 32.6 nTPM (manageable, limit 5); bone marrow: 32 nTPM (vital, limit 1); skin: 30.9 nTPM (manageable, limit 5); thymus: 26.2 nTPM (manageable, limit 5); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 2); midbrain: 23.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 2); colon: 20.3 nTPM (protected, limit 2); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); rectum: 14.5 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000248098,BCKDHA,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6614% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 28.9326% (minimum 99%, Baseline (adaptation disabled)); amygdala: 59.0822% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 57.0111% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 49.1256% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 61.5538% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 55.0802% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 36.2251% (minimum 99%, Baseline (adaptation disabled)); colon: 60.3516% (minimum 97%, Baseline (adaptation disabled)); duodenum: 61.4314% (minimum 99%, Baseline (adaptation disabled)); esophagus: 32.8374% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 26.0980% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 62.8049% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.5802% (minimum 99%, Baseline (adaptation disabled)); kidney: 41.8133% (minimum 99%, Baseline (adaptation disabled)); liver: 22.3589% (minimum 99%, Baseline (adaptation disabled)); lung: 58.7452% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.3869% (minimum 97%, Baseline (adaptation disabled)); midbrain: 56.4899% (minimum 99%, Baseline (adaptation disabled)); pancreas: 40.8190% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 36.2251% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 56.9061% (minimum 99%, Baseline (adaptation disabled)); rectum: 68.0617% (minimum 97%, Baseline (adaptation disabled)); retina: 59.5376% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 43.7677% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 22.5547% (minimum 99%, Baseline (adaptation disabled)); skin: 50.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.9328% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 71.6937% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 62.1730% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.5934% (minimum 95%, Baseline (adaptation disabled)); stomach: 37.6829% (minimum 97%, Baseline (adaptation disabled)); thymus: 54.1156% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 43.3380% (minimum 95%, Baseline (adaptation disabled)); tongue: 20.8643% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.5376% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,107.3,117.2,40.4,"tongue: 117.2 nTPM (protected, limit 2); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 2); parathyroid gland: 54.4 nTPM (protected, limit 2); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 2); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (manageable, limit 5); salivary gland: 39.7 nTPM (protected, limit 2); adipose tissue: 32.6 nTPM (manageable, limit 5); bone marrow: 32 nTPM (vital, limit 1); skin: 30.9 nTPM (manageable, limit 5); thymus: 26.2 nTPM (manageable, limit 5); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 2); midbrain: 23.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 2); colon: 20.3 nTPM (protected, limit 2); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); rectum: 14.5 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000248098,BCKDHA,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.51662,-0.761357,-0.766411
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6614% (minimum 95%, Missing); adrenal gland: 28.9326% (minimum 99%, Missing); amygdala: 59.0822% (minimum 99%, Missing); basal ganglia: 57.0111% (minimum 99%, Missing); bone marrow: 49.1256% (minimum 99%, Missing); cerebellum: 61.5538% (minimum 99%, Missing); cerebral cortex: 55.0802% (minimum 99%, Missing); choroid plexus: 36.2251% (minimum 99%, Missing); colon: 60.3516% (minimum 97%, Missing); duodenum: 61.4314% (minimum 99%, Missing); esophagus: 32.8374% (minimum 97%, Missing); heart muscle: 26.0980% (minimum 99%, Missing); hippocampal formation: 62.8049% (minimum 99%, Missing); hypothalamus: 63.5802% (minimum 99%, Missing); kidney: 41.8133% (minimum 99%, Missing); liver: 22.3589% (minimum 99%, Missing); lung: 58.7452% (minimum 99%, Missing); lymph node: 56.3869% (minimum 97%, Missing); midbrain: 56.4899% (minimum 99%, Missing); pancreas: 40.8190% (minimum 99%, Missing); parathyroid gland: 36.2251% (minimum 97%, Missing); pituitary gland: 56.9061% (minimum 99%, Missing); rectum: 68.0617% (minimum 97%, Missing); retina: 59.5376% (minimum 99%, Missing); salivary gland: 43.7677% (minimum 97%, Missing); skeletal muscle: 22.5547% (minimum 99%, Missing); skin: 50.0000% (minimum 95%, Missing); small intestine: 62.9328% (minimum 99%, Missing); smooth muscle: 71.6937% (minimum 99%, Missing); spinal cord: 62.1730% (minimum 99%, Missing); spleen: 56.5934% (minimum 95%, Missing); stomach: 37.6829% (minimum 97%, Missing); thymus: 54.1156% (minimum 95%, Missing); thyroid gland: 43.3380% (minimum 95%, Missing); tongue: 20.8643% (minimum 97%, Missing); urinary bladder: 59.5376% (minimum 97%, Missing)",0,3,partial,107.3,117.2,40.4,"tongue: 117.2 nTPM (protected, limit 2); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 2); parathyroid gland: 54.4 nTPM (protected, limit 2); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 2); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (manageable, limit 5); salivary gland: 39.7 nTPM (protected, limit 2); adipose tissue: 32.6 nTPM (manageable, limit 5); bone marrow: 32 nTPM (vital, limit 1); skin: 30.9 nTPM (manageable, limit 5); thymus: 26.2 nTPM (manageable, limit 5); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 2); midbrain: 23.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 2); colon: 20.3 nTPM (protected, limit 2); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); rectum: 14.5 nTPM (protected, limit 2); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000248098,BCKDHA,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.51662,-0.761357,-0.766411
True,compatible,,True,True,False,,0,2,partial,1.8,2.8,5.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000248099,INSL3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,True,,0,2,partial,1.8,2.8,5.1,"spleen: 5.1 nTPM (manageable, limit 5); lymph node: 2.8 nTPM (protected, limit 2); bone marrow: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000248099,INSL3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0373197,0.0229982,0.00548759
True,compatible,,True,True,True,,0,2,partial,1.8,2.8,5.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000248099,INSL3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0489937,0.0289937,0.00824032
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,1.1,28.8,0.9,"parathyroid gland: 28.8 nTPM (protected, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; tonsil,ENSG00000248383,PCDHAC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 63.6364% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.6364% (minimum 99%, Baseline (adaptation disabled)); amygdala: 63.6364% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 53.8462% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 41.1765% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 87.5000% (minimum 99%, Baseline (adaptation disabled)); colon: 87.5000% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 63.6364% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 58.3333% (minimum 99%, Baseline (adaptation disabled)); kidney: 77.7778% (minimum 99%, Baseline (adaptation disabled)); liver: 87.5000% (minimum 99%, Baseline (adaptation disabled)); lung: 53.8462% (minimum 99%, Baseline (adaptation disabled)); lymph node: 36.8421% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.6364% (minimum 99%, Baseline (adaptation disabled)); pancreas: 38.8889% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 2.3729% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 50.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.6364% (minimum 97%, Baseline (adaptation disabled)); smooth muscle: 77.7778% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.5000% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.7778% (minimum 95%, Baseline (adaptation disabled)); stomach: 87.5000% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 43.7500% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,1.1,28.8,0.9,"parathyroid gland: 28.8 nTPM (protected, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; tonsil,ENSG00000248383,PCDHAC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.5125,-0.946271,-0.601111
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"adipose tissue: 63.6364% (minimum 95%, Missing); adrenal gland: 63.6364% (minimum 99%, Missing); amygdala: 63.6364% (minimum 99%, Missing); basal ganglia: 70.0000% (minimum 99%, Missing); cerebellum: 53.8462% (minimum 99%, Missing); cerebral cortex: 41.1765% (minimum 99%, Missing); choroid plexus: 87.5000% (minimum 99%, Missing); colon: 87.5000% (minimum 97%, Missing); hippocampal formation: 63.6364% (minimum 99%, Missing); hypothalamus: 58.3333% (minimum 99%, Missing); kidney: 77.7778% (minimum 99%, Missing); liver: 87.5000% (minimum 99%, Missing); lung: 53.8462% (minimum 99%, Missing); lymph node: 36.8421% (minimum 97%, Missing); midbrain: 63.6364% (minimum 99%, Missing); pancreas: 38.8889% (minimum 99%, Missing); parathyroid gland: 2.3729% (minimum 97%, Missing); pituitary gland: 50.0000% (minimum 99%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 63.6364% (minimum 97%, Missing); smooth muscle: 77.7778% (minimum 99%, Missing); spinal cord: 87.5000% (minimum 99%, Missing); spleen: 77.7778% (minimum 95%, Missing); stomach: 87.5000% (minimum 97%, Missing); thyroid gland: 43.7500% (minimum 95%, Missing)",0,80,unavailable,1.1,28.8,0.9,"parathyroid gland: 28.8 nTPM (protected, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; tonsil,ENSG00000248383,PCDHAC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017,-0.5125,-0.946271,-0.601111
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,4,partial,1,0.2,0.4,,kidney / cells in tubules: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000248483,POU5F2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"bone marrow: 82.6087% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.4762% (minimum 99%, Baseline (adaptation disabled)); colon: 95.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 90.4762% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 95.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.4762% (minimum 97%, Baseline (adaptation disabled)); rectum: 95.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 65.5172% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 95.0000% (minimum 97%, Baseline (adaptation disabled)); skin: 82.6087% (minimum 95%, Baseline (adaptation disabled)); small intestine: 90.4762% (minimum 99%, Baseline (adaptation disabled)); stomach: 90.4762% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 90.4762% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.0000% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,1,0.2,0.4,,kidney / cells in tubules: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000248483,POU5F2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,-0.123913,-0.0652381,-0.334828
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"bone marrow: 82.6087% (minimum 95%, Enhanced); cerebral cortex: 90.4762% (minimum 95%, Enhanced); colon: 95.0000% (minimum 97%, Missing); duodenum: 90.4762% (minimum 95%, Enhanced); kidney: 95.0000% (minimum 99%, Missing); retina: 65.5172% (minimum 99%, Missing); small intestine: 90.4762% (minimum 95%, Enhanced); tongue: 95.0000% (minimum 97%, Missing)",0,4,partial,1,0.2,0.4,,kidney / cells in tubules: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000248483,POU5F2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0,-0.02,-0.334828
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000248767,FOXL3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000248767,FOXL3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000248767,FOXL3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,13,partial,29.1,7.7,4,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); colon: 5.5 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); salivary gland: 4.1 nTPM (protected, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / langerhans cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in corneal layer: Low (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: High (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000248905,FMN1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 85.3448% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 93.3962% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.1165% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0198% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.1892% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.8182% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.2000% (minimum 99%, Baseline (adaptation disabled)); colon: 64.2857% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.3929% (minimum 99%, Baseline (adaptation disabled)); esophagus: 83.8983% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 92.5234% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.1923% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.1923% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.5714% (minimum 99%, Baseline (adaptation disabled)); liver: 96.1165% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 91.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 93.3962% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.1892% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 87.6106% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 73.3333% (minimum 99%, Baseline (adaptation disabled)); rectum: 70.2128% (minimum 97%, Baseline (adaptation disabled)); retina: 25.3846% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 70.7143% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 93.3962% (minimum 99%, Baseline (adaptation disabled)); skin: 71.2230% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.6154% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 82.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.8421% (minimum 99%, Baseline (adaptation disabled)); spleen: 90.8257% (minimum 95%, Baseline (adaptation disabled)); stomach: 56.2500% (minimum 97%, Baseline (adaptation disabled)); thymus: 72.7941% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 79.8387% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.1923% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.3929% (minimum 97%, Baseline (adaptation disabled))",0,13,partial,29.1,7.7,4,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); colon: 5.5 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); salivary gland: 4.1 nTPM (protected, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / langerhans cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in corneal layer: Low (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: High (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000248905,FMN1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.23777,-0.4075,-0.736154
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 93.3962% (minimum 99%, Missing); amygdala: 96.1165% (minimum 99%, Missing); basal ganglia: 98.0198% (minimum 99%, Missing); bone marrow: 89.1892% (minimum 97%, Supported); cerebral cortex: 81.8182% (minimum 97%, Supported); choroid plexus: 79.2000% (minimum 99%, Missing); colon: 64.2857% (minimum 97%, Missing); duodenum: 88.3929% (minimum 99%, Missing); esophagus: 83.8983% (minimum 97%, Missing); heart muscle: 92.5234% (minimum 99%, Missing); hippocampal formation: 95.1923% (minimum 99%, Missing); hypothalamus: 95.1923% (minimum 99%, Missing); kidney: 78.5714% (minimum 99%, Missing); liver: 96.1165% (minimum 97%, Supported); lung: 75.0000% (minimum 99%, Missing); midbrain: 93.3962% (minimum 99%, Missing); pancreas: 89.1892% (minimum 99%, Missing); parathyroid gland: 87.6106% (minimum 97%, Missing); pituitary gland: 73.3333% (minimum 99%, Missing); rectum: 70.2128% (minimum 97%, Missing); retina: 25.3846% (minimum 99%, Missing); salivary gland: 70.7143% (minimum 97%, Missing); skeletal muscle: 93.3962% (minimum 99%, Missing); skin: 71.2230% (minimum 95%, Missing); small intestine: 84.6154% (minimum 99%, Missing); smooth muscle: 82.5000% (minimum 99%, Missing); spinal cord: 86.8421% (minimum 99%, Missing); stomach: 56.2500% (minimum 97%, Missing); thymus: 72.7941% (minimum 95%, Missing); thyroid gland: 79.8387% (minimum 80%, Supported); tongue: 95.1923% (minimum 97%, Missing); urinary bladder: 88.3929% (minimum 97%, Missing)",0,13,partial,29.1,7.7,4,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 2); colon: 5.5 nTPM (protected, limit 2); rectum: 4.2 nTPM (protected, limit 2); salivary gland: 4.1 nTPM (protected, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / langerhans cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in corneal layer: Low (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: High (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,ENSG00000248905,FMN1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.23777,-0.4075,-0.736154
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,1,partial,0.1,0,0.1,,,54,not_established,not_triggered,,,ENSG00000249139,EPPIN-WFDC6,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,1,partial,0.1,0,0.1,,,54,not_established,not_triggered,,,ENSG00000249139,EPPIN-WFDC6,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0483974,0.03,0.00839744
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,1,partial,0.1,0,0.1,,,54,not_established,not_triggered,,,ENSG00000249139,EPPIN-WFDC6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.5,2.9,3.7,"pancreas: 3.5 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.5 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000249471,ZNF324B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.9286% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.1111% (minimum 99%, Baseline (adaptation disabled)); amygdala: 66.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 62.2642% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 55.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 52.3810% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.7500% (minimum 99%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.7059% (minimum 99%, Baseline (adaptation disabled)); esophagus: 53.2258% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 66.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.7059% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 66.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 57.8947% (minimum 99%, Baseline (adaptation disabled)); lung: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 60.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.7391% (minimum 99%, Baseline (adaptation disabled)); pancreas: 48.5294% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 56.8966% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 52.3810% (minimum 99%, Baseline (adaptation disabled)); rectum: 66.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 64.7059% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.9322% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 52.3810% (minimum 99%, Baseline (adaptation disabled)); skin: 47.1429% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 61.1111% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 73.3333% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.9322% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.8966% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.0000% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.3469% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 53.2258% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.5,2.9,3.7,"pancreas: 3.5 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.5 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000249471,ZNF324B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.478571,-0.437742,-0.504706
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.9286% (minimum 95%, Missing); adrenal gland: 61.1111% (minimum 99%, Missing); amygdala: 66.0000% (minimum 99%, Missing); basal ganglia: 62.2642% (minimum 99%, Missing); bone marrow: 66.0000% (minimum 99%, Missing); cerebellum: 55.0000% (minimum 99%, Missing); cerebral cortex: 52.3810% (minimum 99%, Missing); choroid plexus: 68.7500% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 64.7059% (minimum 99%, Missing); esophagus: 53.2258% (minimum 97%, Missing); heart muscle: 66.0000% (minimum 99%, Missing); hippocampal formation: 64.7059% (minimum 99%, Missing); hypothalamus: 66.0000% (minimum 99%, Missing); kidney: 60.0000% (minimum 99%, Missing); liver: 57.8947% (minimum 99%, Missing); lung: 60.0000% (minimum 99%, Missing); lymph node: 60.0000% (minimum 97%, Missing); midbrain: 71.7391% (minimum 99%, Missing); pancreas: 48.5294% (minimum 99%, Missing); parathyroid gland: 56.8966% (minimum 97%, Missing); pituitary gland: 52.3810% (minimum 99%, Missing); rectum: 66.0000% (minimum 97%, Missing); retina: 64.7059% (minimum 99%, Missing); salivary gland: 55.9322% (minimum 97%, Missing); skeletal muscle: 52.3810% (minimum 99%, Missing); skin: 47.1429% (minimum 95%, Missing); small intestine: 60.0000% (minimum 99%, Missing); smooth muscle: 61.1111% (minimum 99%, Missing); spinal cord: 73.3333% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 55.9322% (minimum 97%, Missing); thymus: 56.8966% (minimum 95%, Missing); thyroid gland: 55.0000% (minimum 95%, Missing); tongue: 67.3469% (minimum 97%, Missing); urinary bladder: 53.2258% (minimum 97%, Missing)",0,80,unavailable,3.5,2.9,3.7,"pancreas: 3.5 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); urinary bladder: 2.9 nTPM (protected, limit 2); esophagus: 2.9 nTPM (protected, limit 2); cerebellum: 2.7 nTPM (vital, limit 1); stomach: 2.6 nTPM (protected, limit 2); salivary gland: 2.6 nTPM (protected, limit 2); parathyroid gland: 2.5 nTPM (protected, limit 2); liver: 2.4 nTPM (vital, limit 1); colon: 2.2 nTPM (protected, limit 2); small intestine: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); lymph node: 2.2 nTPM (protected, limit 2); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000249471,ZNF324B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.478571,-0.437742,-0.504706
True,compatible,,True,True,False,,0,4,partial,1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000249481,SPATS1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.1651% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.2727% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 95.5357% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 97.2727% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.2727% (minimum 99%, Baseline (adaptation disabled)); lung: 97.2727% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000249481,SPATS1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0453488,0.0253488,-0.0346429
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.1651% (minimum 99%, Missing); basal ganglia: 97.2727% (minimum 99%, Missing); choroid plexus: 95.5357% (minimum 99%, Missing); hippocampal formation: 97.2727% (minimum 99%, Missing); hypothalamus: 97.2727% (minimum 99%, Missing); lung: 97.2727% (minimum 98%, Approved)",0,4,partial,1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,ENSG00000249481,SPATS1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0453488,0.03,-0.0346429
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000249581,CLRN2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"kidney: 50.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 50.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000249581,CLRN2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.47,-0.49
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"kidney: 50.0000% (minimum 99%, Missing); salivary gland: 50.0000% (minimum 97%, Missing)",0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000249581,CLRN2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.47,-0.49
True,compatible,,True,True,False,,0,80,unavailable,0.5,0.2,0.3,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000249693,SPMAP2L,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1136/jitc-2023-007935,Chang 2019;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 91.8919% (minimum 99%, Baseline (adaptation disabled)); colon: 94.4444% (minimum 97%, Baseline (adaptation disabled)); skin: 91.8919% (minimum 95%, Baseline (adaptation disabled)); smooth muscle: 87.1795% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 94.4444% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0.2,0.3,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000249693,SPMAP2L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1136/jitc-2023-007935,Chang 2019;Carter 2023,-0.0310811,-0.0255556,-0.118205
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 91.8919% (minimum 99%, Missing); colon: 94.4444% (minimum 97%, Missing); skin: 91.8919% (minimum 95%, Missing); smooth muscle: 87.1795% (minimum 99%, Missing); urinary bladder: 94.4444% (minimum 97%, Missing)",0,80,unavailable,0.5,0.2,0.3,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,ENSG00000249693,SPMAP2L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1136/jitc-2023-007935,Chang 2019;Carter 2023,-0.0310811,-0.0255556,-0.118205
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,7.4,7.7,7.7,"tongue: 7.7 nTPM (protected, limit 2); thyroid gland: 7.7 nTPM (manageable, limit 5); kidney: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); rectum: 7 nTPM (protected, limit 2); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lymph node: 6.7 nTPM (protected, limit 2); stomach: 6.6 nTPM (protected, limit 2); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 2); heart muscle: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000249709,ZNF564,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 67.9245% (minimum 99%, Baseline (adaptation disabled)); amygdala: 75.7895% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 72.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 62.6087% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 72.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 64.2857% (minimum 99%, Baseline (adaptation disabled)); colon: 50.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 54.1353% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.2871% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.5041% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 75.7895% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 79.1209% (minimum 99%, Baseline (adaptation disabled)); kidney: 49.3151% (minimum 99%, Baseline (adaptation disabled)); liver: 56.6929% (minimum 99%, Baseline (adaptation disabled)); lung: 63.7168% (minimum 99%, Baseline (adaptation disabled)); lymph node: 51.7986% (minimum 97%, Baseline (adaptation disabled)); midbrain: 78.2609% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 49.6552% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.9029% (minimum 99%, Baseline (adaptation disabled)); rectum: 50.7042% (minimum 97%, Baseline (adaptation disabled)); retina: 51.0638% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.5042% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 54.5455% (minimum 99%, Baseline (adaptation disabled)); skin: 58.0645% (minimum 95%, Baseline (adaptation disabled)); small intestine: 51.0638% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 63.1579% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 51.7986% (minimum 95%, Baseline (adaptation disabled)); stomach: 52.1739% (minimum 97%, Baseline (adaptation disabled)); thymus: 49.6552% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 48.3221% (minimum 95%, Baseline (adaptation disabled)); tongue: 48.3221% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.5366% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,7.4,7.7,7.7,"tongue: 7.7 nTPM (protected, limit 2); thyroid gland: 7.7 nTPM (manageable, limit 5); kidney: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); rectum: 7 nTPM (protected, limit 2); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lymph node: 6.7 nTPM (protected, limit 2); stomach: 6.6 nTPM (protected, limit 2); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 2); heart muscle: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000249709,ZNF564,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.466779,-0.486779,-0.496849
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 95%, Missing); adrenal gland: 67.9245% (minimum 99%, Missing); amygdala: 75.7895% (minimum 99%, Missing); basal ganglia: 72.0000% (minimum 99%, Missing); bone marrow: 62.6087% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); cerebral cortex: 72.0000% (minimum 99%, Missing); choroid plexus: 64.2857% (minimum 99%, Missing); colon: 50.0000% (minimum 97%, Missing); duodenum: 54.1353% (minimum 99%, Missing); esophagus: 71.2871% (minimum 97%, Missing); heart muscle: 59.5041% (minimum 99%, Missing); hippocampal formation: 75.7895% (minimum 99%, Missing); hypothalamus: 79.1209% (minimum 99%, Missing); kidney: 49.3151% (minimum 99%, Missing); liver: 56.6929% (minimum 99%, Missing); lung: 63.7168% (minimum 99%, Missing); lymph node: 51.7986% (minimum 97%, Missing); midbrain: 78.2609% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 49.6552% (minimum 97%, Missing); pituitary gland: 69.9029% (minimum 99%, Missing); rectum: 50.7042% (minimum 97%, Missing); retina: 51.0638% (minimum 99%, Missing); salivary gland: 60.5042% (minimum 97%, Missing); skeletal muscle: 54.5455% (minimum 99%, Missing); skin: 58.0645% (minimum 95%, Missing); small intestine: 51.0638% (minimum 99%, Missing); smooth muscle: 63.1579% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 51.7986% (minimum 95%, Missing); stomach: 52.1739% (minimum 97%, Missing); thymus: 49.6552% (minimum 95%, Missing); thyroid gland: 48.3221% (minimum 95%, Missing); tongue: 48.3221% (minimum 97%, Missing); urinary bladder: 58.5366% (minimum 97%, Missing)",0,80,unavailable,7.4,7.7,7.7,"tongue: 7.7 nTPM (protected, limit 2); thyroid gland: 7.7 nTPM (manageable, limit 5); kidney: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 2); colon: 7.2 nTPM (protected, limit 2); rectum: 7 nTPM (protected, limit 2); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lymph node: 6.7 nTPM (protected, limit 2); stomach: 6.6 nTPM (protected, limit 2); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 2); heart muscle: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 2); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); esophagus: 2.9 nTPM (protected, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000249709,ZNF564,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.466779,-0.486779,-0.496849
True,compatible,,True,True,False,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000249861,LGALS16,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 93.3333% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.2456% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.5517% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.2456% (minimum 99%, Baseline (adaptation disabled)); retina: 93.3333% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000249861,LGALS16,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.0566667
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 93.3333% (minimum 99%, Missing); cerebral cortex: 98.2456% (minimum 99%, Missing); hypothalamus: 96.5517% (minimum 99%, Missing); midbrain: 98.2456% (minimum 99%, Missing); retina: 93.3333% (minimum 99%, Missing)",0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000249861,LGALS16,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.0566667
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,4.1,0.9,0.6,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000249884,RNF103-CHMP3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); amygdala: 57.1429% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 48.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 22.6415% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.5882% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 33.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 70.5882% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.1579% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 23.0769% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 60.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.1579% (minimum 99%, Baseline (adaptation disabled)); kidney: 85.7143% (minimum 99%, Baseline (adaptation disabled)); liver: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 85.7143% (minimum 99%, Baseline (adaptation disabled)); lymph node: 80.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 70.5882% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.3077% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 85.7143% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.3077% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 36.3636% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 80.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 57.1429% (minimum 97%, Baseline (adaptation disabled)); thymus: 66.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 85.7143% (minimum 95%, Baseline (adaptation disabled)); tongue: 75.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.3077% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.1,0.9,0.6,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000249884,RNF103-CHMP3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,-0.398571,-0.763585
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 75.0000% (minimum 95%, Missing); adrenal gland: 85.7143% (minimum 99%, Missing); amygdala: 57.1429% (minimum 99%, Missing); basal ganglia: 48.0000% (minimum 99%, Missing); bone marrow: 22.6415% (minimum 99%, Missing); cerebellum: 70.5882% (minimum 99%, Missing); cerebral cortex: 33.3333% (minimum 99%, Missing); colon: 70.5882% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 63.1579% (minimum 97%, Missing); heart muscle: 23.0769% (minimum 99%, Missing); hippocampal formation: 60.0000% (minimum 99%, Missing); hypothalamus: 63.1579% (minimum 99%, Missing); kidney: 85.7143% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lung: 85.7143% (minimum 99%, Missing); lymph node: 80.0000% (minimum 97%, Missing); midbrain: 70.5882% (minimum 99%, Missing); pancreas: 92.3077% (minimum 99%, Missing); parathyroid gland: 80.0000% (minimum 97%, Missing); pituitary gland: 85.7143% (minimum 99%, Missing); rectum: 80.0000% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); salivary gland: 92.3077% (minimum 97%, Missing); skeletal muscle: 36.3636% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 80.0000% (minimum 99%, Missing); smooth muscle: 80.0000% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); spleen: 80.0000% (minimum 95%, Missing); stomach: 57.1429% (minimum 97%, Missing); thymus: 66.6667% (minimum 95%, Missing); thyroid gland: 85.7143% (minimum 95%, Missing); tongue: 75.0000% (minimum 97%, Missing); urinary bladder: 92.3077% (minimum 97%, Missing)",0,80,unavailable,4.1,0.9,0.6,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000249884,RNF103-CHMP3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,-0.398571,-0.763585
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.4,0.3,0.6,"bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000249961,TERB1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.6000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 89.7059% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.6000% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.6000% (minimum 99%, Baseline (adaptation disabled)); lung: 98.3871% (minimum 99%, Baseline (adaptation disabled)); retina: 96.8254% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.4,0.3,0.6,"bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000249961,TERB1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.003125,0.006,-0.0929412
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.6000% (minimum 99%, Missing); bone marrow: 89.7059% (minimum 99%, Missing); cerebral cortex: 97.6000% (minimum 99%, Missing); duodenum: 97.6000% (minimum 99%, Missing); lung: 98.3871% (minimum 99%, Missing); retina: 96.8254% (minimum 99%, Missing)",0,80,unavailable,1.4,0.3,0.6,"bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000249961,TERB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.003125,0.006,-0.0929412
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8,0.7,2,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000250120,PCDHA10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 82.6087% (minimum 99%, Baseline (adaptation disabled)); amygdala: 57.5758% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 55.8824% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 39.5833% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 19.1919% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 86.3636% (minimum 99%, Baseline (adaptation disabled)); colon: 90.4762% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.3636% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.5758% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.5172% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.5758% (minimum 99%, Baseline (adaptation disabled)); lung: 73.0769% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 59.3750% (minimum 99%, Baseline (adaptation disabled)); pancreas: 32.2034% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 73.0769% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 57.5758% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 45.2381% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 79.1667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 95.0000% (minimum 99%, Baseline (adaptation disabled)); small intestine: 73.0769% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.8824% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 42.2222% (minimum 99%, Baseline (adaptation disabled)); stomach: 86.3636% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 48.7179% (minimum 95%, Baseline (adaptation disabled)); tongue: 95.0000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 95.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,8,0.7,2,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000250120,PCDHA10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.462821,-0.239231,-0.798081
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 70.3704% (minimum 95%, Missing); adrenal gland: 82.6087% (minimum 99%, Missing); amygdala: 57.5758% (minimum 99%, Missing); basal ganglia: 55.8824% (minimum 99%, Missing); bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 39.5833% (minimum 99%, Missing); cerebral cortex: 19.1919% (minimum 99%, Missing); choroid plexus: 86.3636% (minimum 99%, Missing); colon: 90.4762% (minimum 97%, Missing); duodenum: 86.3636% (minimum 99%, Missing); heart muscle: 95.0000% (minimum 99%, Missing); hippocampal formation: 57.5758% (minimum 99%, Missing); hypothalamus: 65.5172% (minimum 99%, Missing); kidney: 57.5758% (minimum 99%, Missing); lung: 73.0769% (minimum 99%, Missing); lymph node: 95.0000% (minimum 97%, Missing); midbrain: 59.3750% (minimum 99%, Missing); pancreas: 32.2034% (minimum 99%, Missing); parathyroid gland: 73.0769% (minimum 97%, Missing); pituitary gland: 57.5758% (minimum 99%, Missing); rectum: 95.0000% (minimum 97%, Missing); retina: 45.2381% (minimum 99%, Missing); salivary gland: 79.1667% (minimum 97%, Missing); skeletal muscle: 95.0000% (minimum 99%, Missing); small intestine: 73.0769% (minimum 99%, Missing); smooth muscle: 55.8824% (minimum 99%, Missing); spinal cord: 42.2222% (minimum 99%, Missing); stomach: 86.3636% (minimum 97%, Missing); thyroid gland: 48.7179% (minimum 95%, Missing); tongue: 95.0000% (minimum 97%, Missing); urinary bladder: 95.0000% (minimum 97%, Missing)",0,80,unavailable,8,0.7,2,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000250120,PCDHA10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.462821,-0.239231,-0.798081
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,3.7,4.6,"lymph node: 3.7 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000250312,ZNF718,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.0000% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 52.4590% (minimum 99%, Baseline (adaptation disabled)); amygdala: 71.1111% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 69.5652% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 52.4590% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 60.3774% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.7273% (minimum 99%, Baseline (adaptation disabled)); colon: 57.1429% (minimum 97%, Baseline (adaptation disabled)); duodenum: 66.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.3061% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.7451% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.1111% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 68.0851% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.1429% (minimum 99%, Baseline (adaptation disabled)); liver: 69.5652% (minimum 99%, Baseline (adaptation disabled)); lung: 62.7451% (minimum 99%, Baseline (adaptation disabled)); lymph node: 46.3768% (minimum 97%, Baseline (adaptation disabled)); midbrain: 68.0851% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.1404% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.1724% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.7451% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.3774% (minimum 97%, Baseline (adaptation disabled)); retina: 55.1724% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.3774% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.0488% (minimum 99%, Baseline (adaptation disabled)); skin: 52.4590% (minimum 95%, Baseline (adaptation disabled)); small intestine: 64.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 64.0000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 64.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 53.3333% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 41.5584% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 41.0256% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.3061% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 62.7451% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,3.7,4.6,"lymph node: 3.7 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000250312,ZNF718,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.539744,-0.506232,-0.46541
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.0000% (minimum 95%, Missing); adrenal gland: 52.4590% (minimum 99%, Missing); amygdala: 71.1111% (minimum 99%, Missing); basal ganglia: 69.5652% (minimum 99%, Missing); bone marrow: 52.4590% (minimum 99%, Missing); cerebellum: 60.3774% (minimum 99%, Missing); cerebral cortex: 53.3333% (minimum 99%, Missing); choroid plexus: 72.7273% (minimum 99%, Missing); colon: 57.1429% (minimum 97%, Missing); duodenum: 66.6667% (minimum 99%, Missing); esophagus: 65.3061% (minimum 97%, Missing); heart muscle: 62.7451% (minimum 99%, Missing); hippocampal formation: 71.1111% (minimum 99%, Missing); hypothalamus: 68.0851% (minimum 99%, Missing); kidney: 57.1429% (minimum 99%, Missing); liver: 69.5652% (minimum 99%, Missing); lung: 62.7451% (minimum 99%, Missing); lymph node: 46.3768% (minimum 97%, Missing); midbrain: 68.0851% (minimum 99%, Missing); pancreas: 56.1404% (minimum 99%, Missing); parathyroid gland: 55.1724% (minimum 97%, Missing); pituitary gland: 62.7451% (minimum 99%, Missing); rectum: 60.3774% (minimum 97%, Missing); retina: 55.1724% (minimum 99%, Missing); salivary gland: 60.3774% (minimum 97%, Missing); skeletal muscle: 78.0488% (minimum 99%, Missing); skin: 52.4590% (minimum 95%, Missing); small intestine: 64.0000% (minimum 99%, Missing); smooth muscle: 64.0000% (minimum 99%, Missing); spinal cord: 64.0000% (minimum 99%, Missing); spleen: 53.3333% (minimum 95%, Missing); stomach: 64.0000% (minimum 97%, Missing); thymus: 41.5584% (minimum 95%, Missing); thyroid gland: 41.0256% (minimum 95%, Missing); tongue: 65.3061% (minimum 97%, Missing); urinary bladder: 62.7451% (minimum 97%, Missing)",0,80,unavailable,2.9,3.7,4.6,"lymph node: 3.7 nTPM (protected, limit 2); adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); pancreas: 2.5 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); rectum: 2.1 nTPM (protected, limit 2); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000250312,ZNF718,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.539744,-0.506232,-0.46541
True,compatible,,True,True,False,,0,3,partial,1.3,0,0,,,53,not_established,not_triggered,,,ENSG00000250423,KIAA1210,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 96.9121% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.3,0,0,"adrenal gland: 1.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,ENSG00000250423,KIAA1210,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,0.05,0.03,-0.0208789
True,compatible,,True,True,True,,0,3,partial,1.3,0,0,,,53,not_established,not_triggered,,,ENSG00000250423,KIAA1210,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Chang 2019;Wang 2016;Bruggeman 2018;Gong 2021,0.05,0.03,0.00755501
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,8,partial,4.2,2.3,2.8,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000250565,ATP6V1E2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 93.8776% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 92.6174% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.7460% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.7925% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.8421% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.8421% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 89.9023% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.2432% (minimum 99%, Baseline (adaptation disabled)); colon: 94.5205% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.5714% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.8333% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.8454% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.3204% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 91.3907% (minimum 99%, Baseline (adaptation disabled)); kidney: 93.2432% (minimum 99%, Baseline (adaptation disabled)); liver: 93.5593% (minimum 99%, Baseline (adaptation disabled)); lung: 95.8333% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.1980% (minimum 97%, Baseline (adaptation disabled)); midbrain: 88.4615% (minimum 99%, Baseline (adaptation disabled)); pancreas: 91.0891% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.5205% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 91.0891% (minimum 99%, Baseline (adaptation disabled)); retina: 92.3077% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.3077% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 89.3204% (minimum 99%, Baseline (adaptation disabled)); skin: 90.7895% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.5017% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 97.1831% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 87.8981% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.5593% (minimum 95%, Baseline (adaptation disabled)); stomach: 94.8454% (minimum 97%, Baseline (adaptation disabled)); tongue: 95.5017% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.1980% (minimum 97%, Baseline (adaptation disabled))",0,8,partial,4.2,2.3,2.8,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); salivary gland: 2.3 nTPM (protected, limit 2); retina: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000250565,ATP6V1E2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0421053,-0.0469231,-0.122075
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 92.6174% (minimum 95%, Enhanced); amygdala: 88.7460% (minimum 99%, Missing); basal ganglia: 86.7925% (minimum 99%, Missing); cerebral cortex: 89.9023% (minimum 95%, Enhanced); choroid plexus: 93.2432% (minimum 99%, Missing); colon: 94.5205% (minimum 97%, Missing); duodenum: 98.5714% (minimum 99%, Missing); heart muscle: 94.8454% (minimum 95%, Enhanced); hippocampal formation: 89.3204% (minimum 99%, Missing); hypothalamus: 91.3907% (minimum 99%, Missing); kidney: 93.2432% (minimum 95%, Enhanced); liver: 93.5593% (minimum 95%, Enhanced); midbrain: 88.4615% (minimum 99%, Missing); pancreas: 91.0891% (minimum 95%, Enhanced); pituitary gland: 91.0891% (minimum 99%, Missing); retina: 92.3077% (minimum 99%, Missing); skeletal muscle: 89.3204% (minimum 95%, Enhanced); small intestine: 95.5017% (minimum 99%, Missing); spinal cord: 87.8981% (minimum 99%, Missing); tongue: 95.5017% (minimum 97%, Missing)",0,8,partial,4.2,2.3,2.8,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000250565,ATP6V1E2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,0.00833333,-0.0247945,-0.122075
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.4,0.3,0.1,,,0,not_established,not_triggered,,,ENSG00000250709,CCDC169-SOHLH2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"heart muscle: 96.1165% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.0198% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0.3,0.1,,,0,not_established,not_triggered,,,ENSG00000250709,CCDC169-SOHLH2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.04,0.000588235,-0.028835
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"heart muscle: 96.1165% (minimum 99%, Missing); kidney: 98.0198% (minimum 99%, Missing)",0,80,unavailable,0.4,0.3,0.1,,,0,not_established,not_triggered,,,ENSG00000250709,CCDC169-SOHLH2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.04,0.000588235,-0.028835
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000250719,P3R3URF,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000250719,P3R3URF,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000250719,P3R3URF,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000250741,NT5C1B-RDH14,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000250741,NT5C1B-RDH14,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00382716
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000250741,NT5C1B-RDH14,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00382716
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000250803,ZNF475,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000250803,ZNF475,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0489837,0.03,0.00796954
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,ENSG00000250803,ZNF475,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0489837,0.03,0.00796954
True,compatible,,True,True,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000251258,RFPL4B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 84.2105% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000251258,RFPL4B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.147895
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 84.2105% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000251258,RFPL4B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.147895
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.7,1.9,1.2,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000251493,FOXD1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.1905% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 64.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 74.4186% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.2105% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 71.1111% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 68.0851% (minimum 99%, Baseline (adaptation disabled)); colon: 96.9697% (minimum 97%, Baseline (adaptation disabled)); esophagus: 65.3061% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 74.4186% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 54.2373% (minimum 99%, Baseline (adaptation disabled)); kidney: 60.3774% (minimum 99%, Baseline (adaptation disabled)); lung: 91.4286% (minimum 99%, Baseline (adaptation disabled)); lymph node: 88.8889% (minimum 97%, Baseline (adaptation disabled)); midbrain: 64.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.9697% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 62.7451% (minimum 99%, Baseline (adaptation disabled)); retina: 88.8889% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.0513% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.4286% (minimum 99%, Baseline (adaptation disabled)); skin: 72.7273% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.7273% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 80.0000% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.1176% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 91.4286% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.7451% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 88.8889% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.7,1.9,1.2,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000251493,FOXD1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.222727,-0.342549,-0.447627
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.1905% (minimum 95%, Missing); adrenal gland: 64.0000% (minimum 99%, Missing); amygdala: 74.4186% (minimum 99%, Missing); basal ganglia: 64.0000% (minimum 99%, Missing); cerebellum: 84.2105% (minimum 99%, Missing); cerebral cortex: 71.1111% (minimum 99%, Missing); choroid plexus: 68.0851% (minimum 99%, Missing); colon: 96.9697% (minimum 97%, Missing); esophagus: 65.3061% (minimum 97%, Missing); hippocampal formation: 74.4186% (minimum 99%, Missing); hypothalamus: 54.2373% (minimum 99%, Missing); kidney: 60.3774% (minimum 99%, Missing); lung: 91.4286% (minimum 99%, Missing); lymph node: 88.8889% (minimum 97%, Missing); midbrain: 64.0000% (minimum 99%, Missing); parathyroid gland: 96.9697% (minimum 97%, Missing); pituitary gland: 62.7451% (minimum 99%, Missing); retina: 88.8889% (minimum 99%, Missing); salivary gland: 82.0513% (minimum 97%, Missing); skeletal muscle: 91.4286% (minimum 99%, Missing); skin: 72.7273% (minimum 95%, Missing); small intestine: 72.7273% (minimum 99%, Missing); spinal cord: 80.0000% (minimum 99%, Missing); stomach: 94.1176% (minimum 97%, Missing); thyroid gland: 91.4286% (minimum 95%, Missing); tongue: 62.7451% (minimum 97%, Missing); urinary bladder: 88.8889% (minimum 97%, Missing)",0,80,unavailable,2.7,1.9,1.2,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000251493,FOXD1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.222727,-0.342549,-0.447627
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,8.3,1.4,2,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000251503,CENPS-CORT,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 97.5069% (minimum 99%, Baseline (adaptation disabled)); amygdala: 89.7959% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 88.6650% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 80.9195% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 97.2376% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.2564% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8764% (minimum 99%, Baseline (adaptation disabled)); duodenum: 95.6522% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.1749% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 91.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.9561% (minimum 99%, Baseline (adaptation disabled)); kidney: 94.1176% (minimum 99%, Baseline (adaptation disabled)); liver: 96.7033% (minimum 99%, Baseline (adaptation disabled)); lung: 98.3240% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.9697% (minimum 97%, Baseline (adaptation disabled)); midbrain: 92.3885% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7033% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.1749% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 93.6170% (minimum 99%, Baseline (adaptation disabled)); retina: 93.6170% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.3240% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.8787% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.7033% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.6237% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,8.3,1.4,2,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000251503,CENPS-CORT,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.00376344,-0.00825137,-0.180805
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 97.5069% (minimum 99%, Missing); amygdala: 89.7959% (minimum 99%, Missing); basal ganglia: 88.6650% (minimum 99%, Missing); bone marrow: 80.9195% (minimum 99%, Missing); cerebellum: 97.2376% (minimum 99%, Missing); cerebral cortex: 90.2564% (minimum 99%, Missing); choroid plexus: 98.8764% (minimum 99%, Missing); duodenum: 95.6522% (minimum 99%, Missing); esophagus: 96.1749% (minimum 97%, Missing); hippocampal formation: 91.6667% (minimum 99%, Missing); hypothalamus: 90.9561% (minimum 99%, Missing); kidney: 94.1176% (minimum 99%, Missing); liver: 96.7033% (minimum 99%, Missing); lung: 98.3240% (minimum 99%, Missing); lymph node: 96.9697% (minimum 97%, Missing); midbrain: 92.3885% (minimum 99%, Missing); pancreas: 96.7033% (minimum 99%, Missing); parathyroid gland: 96.1749% (minimum 97%, Missing); pituitary gland: 93.6170% (minimum 99%, Missing); retina: 93.6170% (minimum 99%, Missing); small intestine: 98.3240% (minimum 99%, Missing); spinal cord: 94.8787% (minimum 99%, Missing); stomach: 96.7033% (minimum 97%, Missing); thymus: 94.6237% (minimum 95%, Missing)",0,80,unavailable,8.3,1.4,2,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000251503,CENPS-CORT,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.00376344,-0.00825137,-0.180805
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,1.1,1.3,"pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000253506,NACA2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5782% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.8906% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.8906% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.8906% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5782% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8906% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.4227% (minimum 99%, Baseline (adaptation disabled)); liver: 98.8906% (minimum 99%, Baseline (adaptation disabled)); lung: 98.8906% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.7342% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2677% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.8906% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.4227% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.8906% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.7342% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,1.1,1.3,"pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000253506,NACA2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;da Silva 2017,0.0295918,0.0126772,-0.00732283
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.5782% (minimum 99%, Missing); amygdala: 98.8906% (minimum 99%, Missing); basal ganglia: 98.8906% (minimum 99%, Missing); cerebellum: 98.8906% (minimum 99%, Missing); heart muscle: 98.5782% (minimum 99%, Missing); hippocampal formation: 98.8906% (minimum 99%, Missing); kidney: 98.4227% (minimum 99%, Missing); liver: 98.8906% (minimum 99%, Missing); lung: 98.8906% (minimum 99%, Missing); midbrain: 98.7342% (minimum 99%, Missing); pancreas: 98.2677% (minimum 99%, Missing); pituitary gland: 98.8906% (minimum 99%, Missing); skeletal muscle: 98.4227% (minimum 99%, Missing); small intestine: 98.8906% (minimum 99%, Missing); spinal cord: 98.7342% (minimum 99%, Missing)",0,80,unavailable,1.1,1.1,1.3,"pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000253506,NACA2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;da Silva 2017,0.0295918,0.0126772,-0.00732283
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.6,1.1,1.4,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000253910,PCDHGB2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 75.6757% (minimum 99%, Baseline (adaptation disabled)); amygdala: 48.2759% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 48.2759% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.5517% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 46.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 43.7500% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 93.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 73.6842% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.3333% (minimum 99%, Baseline (adaptation disabled)); esophagus: 77.7778% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 62.2222% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 57.1429% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.2222% (minimum 99%, Baseline (adaptation disabled)); kidney: 82.3529% (minimum 99%, Baseline (adaptation disabled)); liver: 80.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 63.6364% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.3226% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.6364% (minimum 99%, Baseline (adaptation disabled)); pancreas: 77.7778% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 71.7949% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 75.6757% (minimum 99%, Baseline (adaptation disabled)); rectum: 80.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 65.1163% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 77.7778% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 77.7778% (minimum 99%, Baseline (adaptation disabled)); skin: 77.7778% (minimum 95%, Baseline (adaptation disabled)); small intestine: 84.8485% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 66.6667% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 65.1163% (minimum 99%, Baseline (adaptation disabled)); spleen: 82.3529% (minimum 95%, Baseline (adaptation disabled)); stomach: 84.8485% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.3226% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 82.3529% (minimum 95%, Baseline (adaptation disabled)); tongue: 77.7778% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.6757% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.6,1.1,1.4,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000253910,PCDHGB2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.283333,-0.252051,-0.5525
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 66.6667% (minimum 95%, Missing); adrenal gland: 75.6757% (minimum 99%, Missing); amygdala: 48.2759% (minimum 99%, Missing); basal ganglia: 48.2759% (minimum 99%, Missing); bone marrow: 96.5517% (minimum 99%, Missing); cerebellum: 46.6667% (minimum 99%, Missing); cerebral cortex: 43.7500% (minimum 99%, Missing); choroid plexus: 93.3333% (minimum 99%, Missing); colon: 73.6842% (minimum 97%, Missing); duodenum: 93.3333% (minimum 99%, Missing); esophagus: 77.7778% (minimum 97%, Missing); heart muscle: 62.2222% (minimum 99%, Missing); hippocampal formation: 57.1429% (minimum 99%, Missing); hypothalamus: 62.2222% (minimum 99%, Missing); kidney: 82.3529% (minimum 99%, Missing); liver: 80.0000% (minimum 99%, Missing); lung: 63.6364% (minimum 99%, Missing); lymph node: 90.3226% (minimum 97%, Missing); midbrain: 63.6364% (minimum 99%, Missing); pancreas: 77.7778% (minimum 99%, Missing); parathyroid gland: 71.7949% (minimum 97%, Missing); pituitary gland: 75.6757% (minimum 99%, Missing); rectum: 80.0000% (minimum 97%, Missing); retina: 65.1163% (minimum 99%, Missing); salivary gland: 77.7778% (minimum 97%, Missing); skeletal muscle: 77.7778% (minimum 99%, Missing); skin: 77.7778% (minimum 95%, Missing); small intestine: 84.8485% (minimum 99%, Missing); smooth muscle: 66.6667% (minimum 99%, Missing); spinal cord: 65.1163% (minimum 99%, Missing); spleen: 82.3529% (minimum 95%, Missing); stomach: 84.8485% (minimum 97%, Missing); thymus: 90.3226% (minimum 95%, Missing); thyroid gland: 82.3529% (minimum 95%, Missing); tongue: 77.7778% (minimum 97%, Missing); urinary bladder: 75.6757% (minimum 97%, Missing)",0,80,unavailable,3.6,1.1,1.4,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000253910,PCDHGB2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.283333,-0.252051,-0.5525
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,12.4,2.1,0.6,"cerebral cortex: 12.4 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000254221,PCDHGB1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.7500% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 61.1111% (minimum 99%, Baseline (adaptation disabled)); amygdala: 36.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 36.6667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 52.3810% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 8.1481% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 84.6154% (minimum 99%, Baseline (adaptation disabled)); colon: 78.5714% (minimum 97%, Baseline (adaptation disabled)); esophagus: 84.6154% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 68.7500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 44.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 50.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 73.3333% (minimum 99%, Baseline (adaptation disabled)); liver: 91.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 64.7059% (minimum 99%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 61.1111% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 34.3750% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 52.3810% (minimum 99%, Baseline (adaptation disabled)); rectum: 91.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 42.3077% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 78.5714% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 91.6667% (minimum 99%, Baseline (adaptation disabled)); skin: 84.6154% (minimum 95%, Baseline (adaptation disabled)); small intestine: 91.6667% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 57.8947% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 47.8261% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.6667% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 64.7059% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.5714% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 78.5714% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,12.4,2.1,0.6,"cerebral cortex: 12.4 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000254221,PCDHGB1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.302941,-0.62625,-0.908519
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.7500% (minimum 95%, Missing); adrenal gland: 61.1111% (minimum 99%, Missing); amygdala: 36.6667% (minimum 99%, Missing); basal ganglia: 36.6667% (minimum 99%, Missing); cerebellum: 52.3810% (minimum 99%, Missing); cerebral cortex: 8.1481% (minimum 99%, Missing); choroid plexus: 84.6154% (minimum 99%, Missing); colon: 78.5714% (minimum 97%, Missing); esophagus: 84.6154% (minimum 97%, Missing); heart muscle: 68.7500% (minimum 99%, Missing); hippocampal formation: 44.0000% (minimum 99%, Missing); hypothalamus: 50.0000% (minimum 99%, Missing); kidney: 73.3333% (minimum 99%, Missing); liver: 91.6667% (minimum 99%, Missing); lung: 64.7059% (minimum 99%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 61.1111% (minimum 99%, Missing); parathyroid gland: 34.3750% (minimum 97%, Missing); pituitary gland: 52.3810% (minimum 99%, Missing); rectum: 91.6667% (minimum 97%, Missing); retina: 42.3077% (minimum 99%, Missing); salivary gland: 78.5714% (minimum 97%, Missing); skeletal muscle: 91.6667% (minimum 99%, Missing); skin: 84.6154% (minimum 95%, Missing); small intestine: 91.6667% (minimum 99%, Missing); smooth muscle: 57.8947% (minimum 99%, Missing); spinal cord: 47.8261% (minimum 99%, Missing); spleen: 91.6667% (minimum 95%, Missing); stomach: 91.6667% (minimum 97%, Missing); thyroid gland: 64.7059% (minimum 95%, Missing); tongue: 78.5714% (minimum 97%, Missing); urinary bladder: 78.5714% (minimum 97%, Missing)",0,80,unavailable,12.4,2.1,0.6,"cerebral cortex: 12.4 nTPM (vital, limit 1); parathyroid gland: 2.1 nTPM (protected, limit 2); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,ENSG00000254221,PCDHGB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.302941,-0.62625,-0.908519
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.3,5.2,2,"parathyroid gland: 5.2 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000254535,PABPC4L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.6106% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 96.1165% (minimum 99%, Baseline (adaptation disabled)); colon: 96.1165% (minimum 97%, Baseline (adaptation disabled)); duodenum: 97.0588% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.2857% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 85.3448% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.8257% (minimum 99%, Baseline (adaptation disabled)); lung: 95.1923% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.0198% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.0588% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 65.5629% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 97.0588% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 82.5000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.0198% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.0588% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.1475% (minimum 99%, Baseline (adaptation disabled)); thymus: 91.6667% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 83.1933% (minimum 95%, Baseline (adaptation disabled)); tongue: 92.5234% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 94.2857% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.3,5.2,2,"parathyroid gland: 5.2 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000254535,PABPC4L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.118067,-0.314371,-0.178525
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 87.6106% (minimum 95%, Missing); adrenal gland: 96.1165% (minimum 99%, Missing); colon: 96.1165% (minimum 97%, Missing); duodenum: 97.0588% (minimum 99%, Missing); esophagus: 94.2857% (minimum 97%, Missing); heart muscle: 85.3448% (minimum 99%, Missing); kidney: 90.8257% (minimum 99%, Missing); lung: 95.1923% (minimum 99%, Missing); midbrain: 98.0198% (minimum 99%, Missing); pancreas: 97.0588% (minimum 99%, Missing); parathyroid gland: 65.5629% (minimum 97%, Missing); pituitary gland: 97.0588% (minimum 99%, Missing); salivary gland: 82.5000% (minimum 97%, Missing); skeletal muscle: 98.0198% (minimum 99%, Missing); small intestine: 97.0588% (minimum 99%, Missing); smooth muscle: 81.1475% (minimum 99%, Missing); thymus: 91.6667% (minimum 95%, Missing); thyroid gland: 83.1933% (minimum 95%, Missing); tongue: 92.5234% (minimum 97%, Missing); urinary bladder: 94.2857% (minimum 97%, Missing)",0,80,unavailable,2.3,5.2,2,"parathyroid gland: 5.2 nTPM (protected, limit 2); smooth muscle: 2.3 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000254535,PABPC4L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.118067,-0.314371,-0.178525
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.1,1.1,0.9,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000254726,MEX3A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2759% (minimum 99%, Baseline (adaptation disabled)); amygdala: 86.3636% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 90.4762% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 93.4426% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 87.6923% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.0769% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.6102% (minimum 99%, Baseline (adaptation disabled)); colon: 93.4426% (minimum 97%, Baseline (adaptation disabled)); duodenum: 95.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 89.0625% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.2759% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.4762% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.4762% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.6923% (minimum 99%, Baseline (adaptation disabled)); liver: 85.0746% (minimum 99%, Baseline (adaptation disabled)); lung: 93.4426% (minimum 99%, Baseline (adaptation disabled)); lymph node: 96.6102% (minimum 97%, Baseline (adaptation disabled)); midbrain: 91.9355% (minimum 99%, Baseline (adaptation disabled)); pancreas: 93.4426% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.0000% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.6102% (minimum 99%, Baseline (adaptation disabled)); rectum: 93.4426% (minimum 97%, Baseline (adaptation disabled)); retina: 85.0746% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 83.8235% (minimum 97%, Baseline (adaptation disabled)); skin: 93.4426% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 89.0625% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.9355% (minimum 99%, Baseline (adaptation disabled)); stomach: 95.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.3636% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 89.0625% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.1,1.1,0.9,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000254726,MEX3A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0863636,-0.131765,-0.259231
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.2759% (minimum 99%, Missing); amygdala: 86.3636% (minimum 99%, Missing); basal ganglia: 90.4762% (minimum 99%, Missing); bone marrow: 93.4426% (minimum 99%, Missing); cerebellum: 87.6923% (minimum 99%, Missing); cerebral cortex: 73.0769% (minimum 99%, Missing); choroid plexus: 96.6102% (minimum 99%, Missing); colon: 93.4426% (minimum 97%, Missing); duodenum: 95.0000% (minimum 99%, Missing); esophagus: 89.0625% (minimum 97%, Missing); heart muscle: 98.2759% (minimum 99%, Missing); hippocampal formation: 90.4762% (minimum 99%, Missing); hypothalamus: 90.4762% (minimum 99%, Missing); kidney: 87.6923% (minimum 99%, Missing); liver: 85.0746% (minimum 99%, Missing); lung: 93.4426% (minimum 99%, Missing); lymph node: 96.6102% (minimum 97%, Missing); midbrain: 91.9355% (minimum 99%, Missing); pancreas: 93.4426% (minimum 99%, Missing); parathyroid gland: 95.0000% (minimum 97%, Missing); pituitary gland: 96.6102% (minimum 99%, Missing); rectum: 93.4426% (minimum 97%, Missing); retina: 85.0746% (minimum 99%, Missing); salivary gland: 83.8235% (minimum 97%, Missing); skin: 93.4426% (minimum 95%, Missing); small intestine: 95.0000% (minimum 99%, Missing); smooth muscle: 89.0625% (minimum 99%, Missing); spinal cord: 91.9355% (minimum 99%, Missing); stomach: 95.0000% (minimum 97%, Missing); thymus: 86.3636% (minimum 95%, Missing); urinary bladder: 89.0625% (minimum 97%, Missing)",0,80,unavailable,2.1,1.1,0.9,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000254726,MEX3A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.0863636,-0.131765,-0.259231
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,6.4,6,3.6,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000255150,EID3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.1923% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.0588% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.1165% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 91.9505% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 95.4984% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.4286% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.6974% (minimum 99%, Baseline (adaptation disabled)); colon: 95.1923% (minimum 97%, Baseline (adaptation disabled)); duodenum: 98.6711% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.9005% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.2723% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.9612% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.2177% (minimum 99%, Baseline (adaptation disabled)); liver: 97.6974% (minimum 99%, Baseline (adaptation disabled)); lung: 95.3451% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.8257% (minimum 97%, Baseline (adaptation disabled)); midbrain: 97.3770% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.1165% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 94.2857% (minimum 99%, Baseline (adaptation disabled)); retina: 90.2736% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.8065% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 96.4286% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.2177% (minimum 99%, Baseline (adaptation disabled)); stomach: 96.5854% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.2857% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 96.2723% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,6.4,6,3.6,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000255150,EID3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00714286,-0.0617431,-0.0872644
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 95.1923% (minimum 99%, Uncertain); amygdala: 97.0588% (minimum 99%, Missing); basal ganglia: 96.1165% (minimum 99%, Missing); bone marrow: 91.9505% (minimum 99%, Uncertain); cerebellum: 95.4984% (minimum 99%, Missing); cerebral cortex: 96.4286% (minimum 99%, Uncertain); choroid plexus: 97.6974% (minimum 99%, Missing); colon: 95.1923% (minimum 97%, Missing); duodenum: 98.6711% (minimum 99%, Uncertain); heart muscle: 96.9005% (minimum 99%, Missing); hippocampal formation: 96.2723% (minimum 99%, Missing); hypothalamus: 95.9612% (minimum 99%, Missing); kidney: 97.2177% (minimum 99%, Missing); liver: 97.6974% (minimum 99%, Uncertain); lung: 95.3451% (minimum 99%, Uncertain); lymph node: 90.8257% (minimum 97%, Uncertain); midbrain: 97.3770% (minimum 99%, Missing); pancreas: 96.1165% (minimum 99%, Uncertain); pituitary gland: 94.2857% (minimum 99%, Missing); retina: 90.2736% (minimum 99%, Missing); small intestine: 95.8065% (minimum 99%, Uncertain); smooth muscle: 96.4286% (minimum 99%, Uncertain); spinal cord: 97.2177% (minimum 99%, Missing); stomach: 96.5854% (minimum 97%, Uncertain); thymus: 94.2857% (minimum 95%, Missing); urinary bladder: 96.2723% (minimum 97%, Uncertain)",0,2,partial,6.4,6,3.6,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 2); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); colon: 3 nTPM (protected, limit 2); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); urinary bladder: 2.3 nTPM (protected, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,ENSG00000255150,EID3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019;Wang 2016,-0.00714286,-0.0617431,-0.0872644
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000255181,CCDC166,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 97.5610% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000255181,CCDC166,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0143902
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 97.5610% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000255181,CCDC166,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,-0.0143902
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,ENSG00000255223,OR5M11,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"urinary bladder: 50.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,ENSG00000255223,OR5M11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.47,0.01
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"urinary bladder: 50.0000% (minimum 97%, Missing)",0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,ENSG00000255223,OR5M11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,-0.47,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000255251,PRR23D1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000255251,PRR23D1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00945025
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000255251,PRR23D1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.00945025
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000255298,OR8G5,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000255298,OR8G5,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000255298,OR8G5,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,0.8,0.1,8.4,"spleen: 8.4 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000255346,NOX5,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.9091% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.9091% (minimum 97%, Baseline (adaptation disabled)); kidney: 90.9091% (minimum 99%, Baseline (adaptation disabled)); retina: 90.9091% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 55.5556% (minimum 99%, Baseline (adaptation disabled)); spleen: 10.6383% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.9091% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.8,0.1,8.4,"spleen: 8.4 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000255346,NOX5,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.843617,-0.0609091,-0.434444
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 90.9091% (minimum 99%, Missing); esophagus: 90.9091% (minimum 97%, Missing); kidney: 90.9091% (minimum 99%, Missing); retina: 90.9091% (minimum 99%, Missing); smooth muscle: 55.5556% (minimum 99%, Missing); spleen: 10.6383% (minimum 95%, Missing); stomach: 90.9091% (minimum 97%, Missing)",0,80,unavailable,0.8,0.1,8.4,"spleen: 8.4 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,ENSG00000255346,NOX5,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,-0.843617,-0.0609091,-0.434444
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000255359,CCDC179,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000255359,CCDC179,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000255359,CCDC179,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000255378,PRR23D2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 92.8571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.8571% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.8571% (minimum 99%, Baseline (adaptation disabled)); pancreas: 92.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.8571% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000255378,PRR23D2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.0614286
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 92.8571% (minimum 99%, Missing); hippocampal formation: 92.8571% (minimum 99%, Missing); hypothalamus: 92.8571% (minimum 99%, Missing); pancreas: 92.8571% (minimum 99%, Missing); spinal cord: 92.8571% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000255378,PRR23D2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.0614286
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2,0.5,0.5,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000255408,PCDHA3,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.4706% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 65.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 56.5217% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 54.1667% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 39.3939% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 72.2222% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.6667% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.8571% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 81.2500% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 54.1667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 54.1667% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.4211% (minimum 99%, Baseline (adaptation disabled)); lung: 61.9048% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.8571% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.9048% (minimum 99%, Baseline (adaptation disabled)); pancreas: 54.1667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.8571% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 48.1481% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.8571% (minimum 97%, Baseline (adaptation disabled)); retina: 59.0909% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 92.8571% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.8571% (minimum 99%, Baseline (adaptation disabled)); skin: 92.8571% (minimum 95%, Baseline (adaptation disabled)); small intestine: 81.2500% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 81.2500% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 50.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 86.6667% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.6667% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 72.2222% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 86.6667% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2,0.5,0.5,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000255408,PCDHA3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.227778,-0.247778,-0.596061
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 76.4706% (minimum 95%, Missing); adrenal gland: 65.0000% (minimum 99%, Missing); amygdala: 56.5217% (minimum 99%, Missing); basal ganglia: 54.1667% (minimum 99%, Missing); cerebellum: 39.3939% (minimum 99%, Missing); cerebral cortex: 50.0000% (minimum 99%, Missing); colon: 72.2222% (minimum 97%, Missing); duodenum: 86.6667% (minimum 99%, Missing); esophagus: 92.8571% (minimum 97%, Missing); heart muscle: 81.2500% (minimum 99%, Missing); hippocampal formation: 54.1667% (minimum 99%, Missing); hypothalamus: 54.1667% (minimum 99%, Missing); kidney: 68.4211% (minimum 99%, Missing); lung: 61.9048% (minimum 99%, Missing); lymph node: 92.8571% (minimum 97%, Missing); midbrain: 61.9048% (minimum 99%, Missing); pancreas: 54.1667% (minimum 99%, Missing); parathyroid gland: 92.8571% (minimum 97%, Missing); pituitary gland: 48.1481% (minimum 99%, Missing); rectum: 92.8571% (minimum 97%, Missing); retina: 59.0909% (minimum 99%, Missing); salivary gland: 92.8571% (minimum 97%, Missing); skeletal muscle: 92.8571% (minimum 99%, Missing); skin: 92.8571% (minimum 95%, Missing); small intestine: 81.2500% (minimum 99%, Missing); smooth muscle: 81.2500% (minimum 99%, Missing); spinal cord: 50.0000% (minimum 99%, Missing); spleen: 86.6667% (minimum 95%, Missing); stomach: 86.6667% (minimum 97%, Missing); thyroid gland: 72.2222% (minimum 95%, Missing); urinary bladder: 86.6667% (minimum 97%, Missing)",0,80,unavailable,2,0.5,0.5,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000255408,PCDHA3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.227778,-0.247778,-0.596061
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,34.7,37.4,23.4,"tongue: 37.4 nTPM (protected, limit 2); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 2); midbrain: 24.3 nTPM (vital, limit 1); spinal cord: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); thymus: 20.8 nTPM (manageable, limit 5); spleen: 20.7 nTPM (manageable, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 2); adipose tissue: 18.7 nTPM (manageable, limit 5); cerebral cortex: 18.7 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 2); colon: 15 nTPM (protected, limit 2); skin: 14.9 nTPM (manageable, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 2); stomach: 14.6 nTPM (protected, limit 2); urinary bladder: 14.6 nTPM (protected, limit 2); rectum: 14.6 nTPM (protected, limit 2); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000255529,POLR2M,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.2447% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.3962% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.4535% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 64.9903% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 66.7992% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.1678% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 64.2447% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 77.9582% (minimum 99%, Baseline (adaptation disabled)); colon: 69.1358% (minimum 97%, Baseline (adaptation disabled)); duodenum: 73.8462% (minimum 99%, Baseline (adaptation disabled)); esophagus: 69.4215% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 54.4571% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.2768% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 62.9213% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.3962% (minimum 99%, Baseline (adaptation disabled)); liver: 69.2784% (minimum 99%, Baseline (adaptation disabled)); lung: 70.8861% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.2447% (minimum 97%, Baseline (adaptation disabled)); midbrain: 58.0311% (minimum 99%, Baseline (adaptation disabled)); pancreas: 68.2927% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.6329% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 79.2453% (minimum 99%, Baseline (adaptation disabled)); rectum: 69.7095% (minimum 97%, Baseline (adaptation disabled)); retina: 73.2026% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.2927% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 49.1947% (minimum 99%, Baseline (adaptation disabled)); skin: 69.2784% (minimum 95%, Baseline (adaptation disabled)); small intestine: 72.4138% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 56.2814% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 58.0311% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.8785% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.7095% (minimum 97%, Baseline (adaptation disabled)); thymus: 61.7647% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.9474% (minimum 95%, Baseline (adaptation disabled)); tongue: 47.3239% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 69.7095% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,34.7,37.4,23.4,"tongue: 37.4 nTPM (protected, limit 2); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 2); midbrain: 24.3 nTPM (vital, limit 1); spinal cord: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); thymus: 20.8 nTPM (manageable, limit 5); spleen: 20.7 nTPM (manageable, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 2); adipose tissue: 18.7 nTPM (manageable, limit 5); cerebral cortex: 18.7 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 2); colon: 15 nTPM (protected, limit 2); skin: 14.9 nTPM (manageable, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 2); stomach: 14.6 nTPM (protected, limit 2); urinary bladder: 14.6 nTPM (protected, limit 2); rectum: 14.6 nTPM (protected, limit 2); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000255529,POLR2M,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.360526,-0.496761,-0.498053
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.2447% (minimum 95%, Missing); adrenal gland: 63.3962% (minimum 99%, Missing); amygdala: 62.4535% (minimum 99%, Missing); basal ganglia: 64.9903% (minimum 99%, Missing); bone marrow: 66.7992% (minimum 99%, Missing); cerebellum: 75.1678% (minimum 99%, Missing); cerebral cortex: 64.2447% (minimum 99%, Missing); choroid plexus: 77.9582% (minimum 99%, Missing); colon: 69.1358% (minimum 97%, Missing); duodenum: 73.8462% (minimum 99%, Missing); esophagus: 69.4215% (minimum 97%, Missing); heart muscle: 54.4571% (minimum 99%, Missing); hippocampal formation: 63.2768% (minimum 99%, Missing); hypothalamus: 62.9213% (minimum 99%, Missing); kidney: 63.3962% (minimum 99%, Missing); liver: 69.2784% (minimum 99%, Missing); lung: 70.8861% (minimum 99%, Missing); lymph node: 64.2447% (minimum 97%, Missing); midbrain: 58.0311% (minimum 99%, Missing); pancreas: 68.2927% (minimum 99%, Missing); parathyroid gland: 57.6329% (minimum 97%, Missing); pituitary gland: 79.2453% (minimum 99%, Missing); rectum: 69.7095% (minimum 97%, Missing); retina: 73.2026% (minimum 99%, Missing); salivary gland: 68.2927% (minimum 97%, Missing); skeletal muscle: 49.1947% (minimum 99%, Missing); skin: 69.2784% (minimum 95%, Missing); small intestine: 72.4138% (minimum 99%, Missing); smooth muscle: 56.2814% (minimum 99%, Missing); spinal cord: 58.0311% (minimum 99%, Missing); spleen: 61.8785% (minimum 95%, Missing); stomach: 69.7095% (minimum 97%, Missing); thymus: 61.7647% (minimum 95%, Missing); thyroid gland: 58.9474% (minimum 95%, Missing); tongue: 47.3239% (minimum 97%, Missing); urinary bladder: 69.7095% (minimum 97%, Missing)",0,80,unavailable,34.7,37.4,23.4,"tongue: 37.4 nTPM (protected, limit 2); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 2); midbrain: 24.3 nTPM (vital, limit 1); spinal cord: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); thymus: 20.8 nTPM (manageable, limit 5); spleen: 20.7 nTPM (manageable, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 2); adipose tissue: 18.7 nTPM (manageable, limit 5); cerebral cortex: 18.7 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 2); colon: 15 nTPM (protected, limit 2); skin: 14.9 nTPM (manageable, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 2); stomach: 14.6 nTPM (protected, limit 2); urinary bladder: 14.6 nTPM (protected, limit 2); rectum: 14.6 nTPM (protected, limit 2); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000255529,POLR2M,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.360526,-0.496761,-0.498053
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,3,partial,28.7,8.4,8.5,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 2); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000256061,DNAAF4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.6977% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 83.5714% (minimum 99%, Baseline (adaptation disabled)); amygdala: 82.9787% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 79.5918% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 86.0294% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 96.6942% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 79.5918% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 40.2062% (minimum 99%, Baseline (adaptation disabled)); colon: 92.1260% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.8571% (minimum 99%, Baseline (adaptation disabled)); esophagus: 90.6977% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 87.9699% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 82.3944% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.9740% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.0599% (minimum 99%, Baseline (adaptation disabled)); liver: 95.1220% (minimum 99%, Baseline (adaptation disabled)); lung: 72.6708% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 86.6667% (minimum 99%, Baseline (adaptation disabled)); pancreas: 85.4015% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 58.2090% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 76.9737% (minimum 99%, Baseline (adaptation disabled)); rectum: 90.6977% (minimum 97%, Baseline (adaptation disabled)); retina: 28.9604% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 87.3134% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 92.1260% (minimum 99%, Baseline (adaptation disabled)); skin: 82.3944% (minimum 95%, Baseline (adaptation disabled)); small intestine: 92.1260% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 84.7826% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.6977% (minimum 99%, Baseline (adaptation disabled)); spleen: 89.3130% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.6977% (minimum 97%, Baseline (adaptation disabled)); thymus: 94.3548% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 57.9208% (minimum 95%, Baseline (adaptation disabled)); tongue: 93.6000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 89.3130% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,28.7,8.4,8.5,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 2); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000256061,DNAAF4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.370792,-0.38791,-0.700396
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 90.6977% (minimum 95%, Uncertain); adrenal gland: 83.5714% (minimum 99%, Missing); amygdala: 82.9787% (minimum 99%, Missing); basal ganglia: 79.5918% (minimum 99%, Missing); bone marrow: 86.0294% (minimum 99%, Missing); cerebellum: 96.6942% (minimum 99%, Missing); cerebral cortex: 79.5918% (minimum 99%, Missing); choroid plexus: 40.2062% (minimum 99%, Missing); colon: 92.1260% (minimum 97%, Missing); duodenum: 92.8571% (minimum 99%, Missing); esophagus: 90.6977% (minimum 97%, Missing); heart muscle: 87.9699% (minimum 99%, Missing); hippocampal formation: 82.3944% (minimum 99%, Missing); hypothalamus: 75.9740% (minimum 99%, Missing); kidney: 70.0599% (minimum 99%, Missing); liver: 95.1220% (minimum 99%, Missing); lung: 72.6708% (minimum 99%, Uncertain); lymph node: 90.0000% (minimum 97%, Missing); midbrain: 86.6667% (minimum 99%, Missing); pancreas: 85.4015% (minimum 99%, Missing); parathyroid gland: 58.2090% (minimum 97%, Missing); pituitary gland: 76.9737% (minimum 99%, Missing); rectum: 90.6977% (minimum 97%, Missing); retina: 28.9604% (minimum 99%, Missing); salivary gland: 87.3134% (minimum 97%, Missing); skeletal muscle: 92.1260% (minimum 99%, Missing); skin: 82.3944% (minimum 95%, Missing); small intestine: 92.1260% (minimum 99%, Missing); smooth muscle: 84.7826% (minimum 99%, Missing); spinal cord: 90.6977% (minimum 99%, Missing); spleen: 89.3130% (minimum 95%, Missing); stomach: 90.6977% (minimum 97%, Missing); thymus: 94.3548% (minimum 95%, Missing); thyroid gland: 57.9208% (minimum 95%, Missing); tongue: 93.6000% (minimum 97%, Missing); urinary bladder: 89.3130% (minimum 97%, Missing)",0,3,partial,28.7,8.4,8.5,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 2); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000256061,DNAAF4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.370792,-0.38791,-0.700396
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,44.1,16.8,20.5,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (manageable, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 2); kidney: 10.6 nTPM (vital, limit 1); liver: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); stomach: 10.2 nTPM (protected, limit 2); skin: 8.6 nTPM (manageable, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); salivary gland: 7.7 nTPM (protected, limit 2); thymus: 7.5 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 2); rectum: 6 nTPM (protected, limit 2); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 2); esophagus: 5.8 nTPM (protected, limit 2); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256223,ZNF10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.8912% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.3978% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.5766% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 82.3741% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 72.9299% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 77.3649% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 80.3509% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 66.1850% (minimum 99%, Baseline (adaptation disabled)); colon: 68.3582% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.4151% (minimum 99%, Baseline (adaptation disabled)); esophagus: 79.7909% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 74.1100% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 83.8828% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 78.9655% (minimum 99%, Baseline (adaptation disabled)); kidney: 68.3582% (minimum 99%, Baseline (adaptation disabled)); liver: 68.7688% (minimum 99%, Baseline (adaptation disabled)); lung: 75.5776% (minimum 99%, Baseline (adaptation disabled)); lymph node: 79.7909% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.5018% (minimum 99%, Baseline (adaptation disabled)); pancreas: 64.1457% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 57.6826% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 34.1791% (minimum 99%, Baseline (adaptation disabled)); rectum: 79.2388% (minimum 97%, Baseline (adaptation disabled)); retina: 64.3258% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 74.8366% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 82.9710% (minimum 99%, Baseline (adaptation disabled)); skin: 72.6984% (minimum 95%, Baseline (adaptation disabled)); small intestine: 76.8456% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 73.3974% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.6715% (minimum 99%, Baseline (adaptation disabled)); spleen: 79.5139% (minimum 95%, Baseline (adaptation disabled)); stomach: 69.1843% (minimum 97%, Baseline (adaptation disabled)); thymus: 75.3289% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.7650% (minimum 95%, Baseline (adaptation disabled)); tongue: 78.9655% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.7688% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,44.1,16.8,20.5,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (manageable, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 2); kidney: 10.6 nTPM (vital, limit 1); liver: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); stomach: 10.2 nTPM (protected, limit 2); skin: 8.6 nTPM (manageable, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); salivary gland: 7.7 nTPM (protected, limit 2); thymus: 7.5 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 2); rectum: 6 nTPM (protected, limit 2); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 2); esophagus: 5.8 nTPM (protected, limit 2); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256223,ZNF10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.42235,-0.393174,-0.648209
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 77.8912% (minimum 95%, Missing); adrenal gland: 62.3978% (minimum 99%, Missing); amygdala: 83.5766% (minimum 99%, Missing); basal ganglia: 82.3741% (minimum 99%, Missing); bone marrow: 72.9299% (minimum 99%, Missing); cerebellum: 77.3649% (minimum 99%, Missing); cerebral cortex: 80.3509% (minimum 99%, Missing); choroid plexus: 66.1850% (minimum 99%, Missing); colon: 68.3582% (minimum 97%, Missing); duodenum: 86.4151% (minimum 99%, Missing); esophagus: 79.7909% (minimum 97%, Missing); heart muscle: 74.1100% (minimum 99%, Missing); hippocampal formation: 83.8828% (minimum 99%, Missing); hypothalamus: 78.9655% (minimum 99%, Missing); kidney: 68.3582% (minimum 99%, Missing); liver: 68.7688% (minimum 99%, Missing); lung: 75.5776% (minimum 99%, Missing); lymph node: 79.7909% (minimum 97%, Missing); midbrain: 84.5018% (minimum 99%, Missing); pancreas: 64.1457% (minimum 99%, Missing); parathyroid gland: 57.6826% (minimum 97%, Missing); pituitary gland: 34.1791% (minimum 99%, Missing); rectum: 79.2388% (minimum 97%, Missing); retina: 64.3258% (minimum 99%, Missing); salivary gland: 74.8366% (minimum 97%, Missing); skeletal muscle: 82.9710% (minimum 99%, Missing); skin: 72.6984% (minimum 95%, Missing); small intestine: 76.8456% (minimum 99%, Missing); smooth muscle: 73.3974% (minimum 99%, Missing); spinal cord: 82.6715% (minimum 99%, Missing); spleen: 79.5139% (minimum 95%, Missing); stomach: 69.1843% (minimum 97%, Missing); thymus: 75.3289% (minimum 95%, Missing); thyroid gland: 52.7650% (minimum 95%, Missing); tongue: 78.9655% (minimum 97%, Missing); urinary bladder: 68.7688% (minimum 97%, Missing)",0,80,unavailable,44.1,16.8,20.5,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (manageable, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 2); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 2); kidney: 10.6 nTPM (vital, limit 1); liver: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 2); stomach: 10.2 nTPM (protected, limit 2); skin: 8.6 nTPM (manageable, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); salivary gland: 7.7 nTPM (protected, limit 2); thymus: 7.5 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 2); rectum: 6 nTPM (protected, limit 2); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 2); esophagus: 5.8 nTPM (protected, limit 2); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256223,ZNF10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.42235,-0.393174,-0.648209
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,6.7,4.3,5.1,"retina: 6.7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); parathyroid gland: 4.3 nTPM (protected, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256294,ZNF225,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.5172% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 80.0000% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.5714% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 86.1111% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 84.3537% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.4872% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 78.9809% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 76.5432% (minimum 99%, Baseline (adaptation disabled)); colon: 83.7838% (minimum 97%, Baseline (adaptation disabled)); duodenum: 83.7838% (minimum 99%, Baseline (adaptation disabled)); esophagus: 86.1111% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.3239% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.5714% (minimum 99%, Baseline (adaptation disabled)); kidney: 81.0458% (minimum 99%, Baseline (adaptation disabled)); liver: 82.1192% (minimum 99%, Baseline (adaptation disabled)); lung: 82.1192% (minimum 99%, Baseline (adaptation disabled)); lymph node: 77.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 87.9433% (minimum 99%, Baseline (adaptation disabled)); pancreas: 86.7133% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 74.2515% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 83.7838% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.7838% (minimum 97%, Baseline (adaptation disabled)); retina: 64.9215% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 80.5195% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 83.2215% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 85.5172% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.7838% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 86.1111% (minimum 99%, Baseline (adaptation disabled)); spleen: 76.0736% (minimum 95%, Baseline (adaptation disabled)); stomach: 81.0458% (minimum 97%, Baseline (adaptation disabled)); thymus: 70.8571% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 76.0736% (minimum 95%, Baseline (adaptation disabled)); tongue: 84.3537% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 83.2215% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,6.7,4.3,5.1,"retina: 6.7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); parathyroid gland: 4.3 nTPM (protected, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256294,ZNF225,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.241429,-0.227485,-0.340785
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 85.5172% (minimum 95%, Missing); adrenal gland: 80.0000% (minimum 99%, Missing); amygdala: 88.5714% (minimum 99%, Missing); basal ganglia: 86.1111% (minimum 99%, Missing); bone marrow: 84.3537% (minimum 99%, Missing); cerebellum: 79.4872% (minimum 99%, Missing); cerebral cortex: 78.9809% (minimum 99%, Missing); choroid plexus: 76.5432% (minimum 99%, Missing); colon: 83.7838% (minimum 97%, Missing); duodenum: 83.7838% (minimum 99%, Missing); esophagus: 86.1111% (minimum 97%, Missing); heart muscle: 80.0000% (minimum 99%, Missing); hippocampal formation: 87.3239% (minimum 99%, Missing); hypothalamus: 88.5714% (minimum 99%, Missing); kidney: 81.0458% (minimum 99%, Missing); liver: 82.1192% (minimum 99%, Missing); lung: 82.1192% (minimum 99%, Missing); lymph node: 77.5000% (minimum 97%, Missing); midbrain: 87.9433% (minimum 99%, Missing); pancreas: 86.7133% (minimum 99%, Missing); parathyroid gland: 74.2515% (minimum 97%, Missing); pituitary gland: 83.7838% (minimum 99%, Missing); rectum: 83.7838% (minimum 97%, Missing); retina: 64.9215% (minimum 99%, Missing); salivary gland: 80.5195% (minimum 97%, Missing); skeletal muscle: 83.2215% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 85.5172% (minimum 99%, Missing); smooth muscle: 83.7838% (minimum 99%, Missing); spinal cord: 86.1111% (minimum 99%, Missing); spleen: 76.0736% (minimum 95%, Missing); stomach: 81.0458% (minimum 97%, Missing); thymus: 70.8571% (minimum 95%, Missing); thyroid gland: 76.0736% (minimum 95%, Missing); tongue: 84.3537% (minimum 97%, Missing); urinary bladder: 83.2215% (minimum 97%, Missing)",0,80,unavailable,6.7,4.3,5.1,"retina: 6.7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); parathyroid gland: 4.3 nTPM (protected, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 2); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); salivary gland: 3 nTPM (protected, limit 2); stomach: 2.9 nTPM (protected, limit 2); kidney: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); colon: 2.4 nTPM (protected, limit 2); rectum: 2.4 nTPM (protected, limit 2); bone marrow: 2.3 nTPM (vital, limit 1); tongue: 2.3 nTPM (protected, limit 2); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256294,ZNF225,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.241429,-0.227485,-0.340785
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3,0.4,1,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256453,DND1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.3333% (minimum 99%, Baseline (adaptation disabled)); amygdala: 94.4000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.4729% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 98.3333% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 79.7297% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.9134% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 90.0763% (minimum 99%, Baseline (adaptation disabled)); colon: 96.7213% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 96.7213% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 94.4000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 94.4000% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.1875% (minimum 99%, Baseline (adaptation disabled)); liver: 92.1875% (minimum 99%, Baseline (adaptation disabled)); lung: 95.1613% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.1613% (minimum 99%, Baseline (adaptation disabled)); pancreas: 94.4000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.7213% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.7692% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 94.4000% (minimum 99%, Baseline (adaptation disabled)); small intestine: 95.1613% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 94.4000% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.1875% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3,0.4,1,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256453,DND1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.028125,-0.00278689,-0.192703
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 98.3333% (minimum 99%, Missing); amygdala: 94.4000% (minimum 99%, Missing); basal ganglia: 91.4729% (minimum 99%, Missing); bone marrow: 98.3333% (minimum 99%, Missing); cerebellum: 79.7297% (minimum 99%, Missing); cerebral cortex: 92.9134% (minimum 99%, Missing); choroid plexus: 90.0763% (minimum 99%, Missing); colon: 96.7213% (minimum 97%, Missing); heart muscle: 96.7213% (minimum 99%, Missing); hippocampal formation: 94.4000% (minimum 99%, Missing); hypothalamus: 94.4000% (minimum 99%, Missing); kidney: 92.1875% (minimum 99%, Missing); liver: 92.1875% (minimum 99%, Missing); lung: 95.1613% (minimum 99%, Missing); midbrain: 95.1613% (minimum 99%, Missing); pancreas: 94.4000% (minimum 99%, Missing); parathyroid gland: 96.7213% (minimum 97%, Missing); pituitary gland: 90.7692% (minimum 99%, Missing); skeletal muscle: 94.4000% (minimum 99%, Missing); small intestine: 95.1613% (minimum 99%, Missing); smooth muscle: 98.3333% (minimum 99%, Missing); spinal cord: 94.4000% (minimum 99%, Missing); spleen: 92.1875% (minimum 95%, Missing)",0,80,unavailable,3,0.4,1,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256453,DND1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.028125,-0.00278689,-0.192703
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,5.4,0.1,4.3,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256660,CLEC12B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 70.6522% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.2963% (minimum 99%, Baseline (adaptation disabled)); liver: 98.4848% (minimum 99%, Baseline (adaptation disabled)); lung: 94.8905% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.4848% (minimum 99%, Baseline (adaptation disabled)); skin: 75.1445% (minimum 95%, Baseline (adaptation disabled)); spleen: 89.6552% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,5.4,0.1,4.3,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256660,CLEC12B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.198555,0.0223664,-0.283478
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 70.6522% (minimum 99%, Missing); choroid plexus: 96.2963% (minimum 99%, Missing); liver: 98.4848% (minimum 99%, Missing); lung: 94.8905% (minimum 99%, Missing); midbrain: 98.4848% (minimum 99%, Missing); skin: 75.1445% (minimum 95%, Missing); spleen: 89.6552% (minimum 95%, Missing)",0,80,unavailable,5.4,0.1,4.3,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000256660,CLEC12B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Chang 2019;Wang 2016;Bruggeman 2018,-0.198555,0.0223664,-0.283478
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,8.1,0.1,0.4,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus; tonsil,ENSG00000256980,KHDC1L,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 80.5970% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 40.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.4286% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 84.3750% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 87.0968% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 87.0968% (minimum 99%, Baseline (adaptation disabled)); lung: 90.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 83.0769% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.1818% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 78.2609% (minimum 99%, Baseline (adaptation disabled)); retina: 91.5254% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 91.5254% (minimum 99%, Baseline (adaptation disabled)); thymus: 93.1034% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,8.1,0.1,0.4,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus; tonsil,ENSG00000256980,KHDC1L,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0189655,0.0118182,-0.59
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 80.5970% (minimum 99%, Missing); basal ganglia: 40.0000% (minimum 99%, Missing); bone marrow: 96.4286% (minimum 99%, Missing); cerebellum: 75.0000% (minimum 99%, Missing); cerebral cortex: 84.3750% (minimum 99%, Missing); hippocampal formation: 87.0968% (minimum 99%, Missing); hypothalamus: 87.0968% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); midbrain: 83.0769% (minimum 99%, Missing); pancreas: 98.1818% (minimum 99%, Missing); pituitary gland: 78.2609% (minimum 99%, Missing); retina: 91.5254% (minimum 99%, Missing); spinal cord: 91.5254% (minimum 99%, Missing); thymus: 93.1034% (minimum 95%, Missing)",0,80,unavailable,8.1,0.1,0.4,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus; tonsil,ENSG00000256980,KHDC1L,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.0189655,0.0118182,-0.59
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,36.7,12.6,11.6,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 2); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); thymus: 11.6 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 2); salivary gland: 10.1 nTPM (protected, limit 2); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 2); amygdala: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 2); adipose tissue: 9.7 nTPM (manageable, limit 5); urinary bladder: 9.6 nTPM (protected, limit 2); stomach: 9.3 nTPM (protected, limit 2); skin: 9.2 nTPM (manageable, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); esophagus: 8.5 nTPM (protected, limit 2); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000257218,GATC,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 53.7037% (minimum 99%, Baseline (adaptation disabled)); amygdala: 53.9535% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 56.0386% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 61.3757% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 43.6090% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 50.6550% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.8832% (minimum 99%, Baseline (adaptation disabled)); colon: 54.2056% (minimum 97%, Baseline (adaptation disabled)); duodenum: 50.4348% (minimum 99%, Baseline (adaptation disabled)); esophagus: 57.7114% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 64.4444% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 51.3274% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 53.7037% (minimum 99%, Baseline (adaptation disabled)); kidney: 44.1065% (minimum 99%, Baseline (adaptation disabled)); liver: 42.3358% (minimum 99%, Baseline (adaptation disabled)); lung: 58.2915% (minimum 99%, Baseline (adaptation disabled)); lymph node: 53.9535% (minimum 97%, Baseline (adaptation disabled)); midbrain: 50.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 24.0166% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 47.9339% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 60.1036% (minimum 99%, Baseline (adaptation disabled)); rectum: 52.9680% (minimum 97%, Baseline (adaptation disabled)); retina: 48.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 53.4562% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 58.5859% (minimum 99%, Baseline (adaptation disabled)); skin: 55.7692% (minimum 95%, Baseline (adaptation disabled)); small intestine: 53.9535% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.7330% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 43.2836% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.3107% (minimum 95%, Baseline (adaptation disabled)); stomach: 55.5024% (minimum 97%, Baseline (adaptation disabled)); thymus: 50.0000% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 50.8772% (minimum 95%, Baseline (adaptation disabled)); tongue: 60.1036% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 54.7170% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,36.7,12.6,11.6,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 2); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); thymus: 11.6 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 2); salivary gland: 10.1 nTPM (protected, limit 2); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 2); amygdala: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 2); adipose tissue: 9.7 nTPM (manageable, limit 5); urinary bladder: 9.6 nTPM (protected, limit 2); stomach: 9.3 nTPM (protected, limit 2); skin: 9.2 nTPM (manageable, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); esophagus: 8.5 nTPM (protected, limit 2); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000257218,GATC,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.490661,-0.749834
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 95%, Missing); adrenal gland: 53.7037% (minimum 99%, Missing); amygdala: 53.9535% (minimum 99%, Missing); basal ganglia: 56.0386% (minimum 99%, Missing); bone marrow: 61.3757% (minimum 99%, Missing); cerebellum: 43.6090% (minimum 99%, Missing); cerebral cortex: 50.6550% (minimum 99%, Missing); choroid plexus: 58.8832% (minimum 99%, Missing); colon: 54.2056% (minimum 97%, Missing); duodenum: 50.4348% (minimum 99%, Missing); esophagus: 57.7114% (minimum 97%, Missing); heart muscle: 64.4444% (minimum 99%, Missing); hippocampal formation: 51.3274% (minimum 99%, Missing); hypothalamus: 53.7037% (minimum 99%, Missing); kidney: 44.1065% (minimum 99%, Missing); liver: 42.3358% (minimum 99%, Missing); lung: 58.2915% (minimum 99%, Missing); lymph node: 53.9535% (minimum 97%, Missing); midbrain: 50.0000% (minimum 99%, Missing); pancreas: 24.0166% (minimum 99%, Missing); parathyroid gland: 47.9339% (minimum 97%, Missing); pituitary gland: 60.1036% (minimum 99%, Missing); rectum: 52.9680% (minimum 97%, Missing); retina: 48.3333% (minimum 99%, Missing); salivary gland: 53.4562% (minimum 97%, Missing); skeletal muscle: 58.5859% (minimum 99%, Missing); skin: 55.7692% (minimum 95%, Missing); small intestine: 53.9535% (minimum 99%, Missing); smooth muscle: 60.7330% (minimum 99%, Missing); spinal cord: 43.2836% (minimum 99%, Missing); spleen: 56.3107% (minimum 95%, Missing); stomach: 55.5024% (minimum 97%, Missing); thymus: 50.0000% (minimum 95%, Missing); thyroid gland: 50.8772% (minimum 95%, Missing); tongue: 60.1036% (minimum 97%, Missing); urinary bladder: 54.7170% (minimum 97%, Missing)",0,80,unavailable,36.7,12.6,11.6,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 2); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); thymus: 11.6 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 2); salivary gland: 10.1 nTPM (protected, limit 2); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 2); amygdala: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 2); adipose tissue: 9.7 nTPM (manageable, limit 5); urinary bladder: 9.6 nTPM (protected, limit 2); stomach: 9.3 nTPM (protected, limit 2); skin: 9.2 nTPM (manageable, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); esophagus: 8.5 nTPM (protected, limit 2); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 2); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000257218,GATC,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.45,-0.490661,-0.749834
True,compatible,,True,True,False,,0,80,unavailable,0.2,1.1,0,,,0,not_established,not_triggered,,,ENSG00000257987,SPMIP11,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"stomach: 94.8357% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.2,1.1,0,,,0,not_established,not_triggered,,,ENSG00000257987,SPMIP11,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.05,-0.0216432,0.000196078
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"stomach: 94.8357% (minimum 97%, Missing)",0,80,unavailable,0.2,1.1,0,,,0,not_established,not_triggered,,,ENSG00000257987,SPMIP11,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019;Gong 2021,0.05,-0.0216432,0.000196078
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000258223,PRSS58,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000258223,PRSS58,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0460317,0.03,0.00603175
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000258223,PRSS58,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;da Silva 2017,0.0460317,0.03,0.00603175
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,80,51.8,59.2,"skeletal muscle: 80 nTPM (vital, limit 1); thymus: 59.2 nTPM (manageable, limit 5); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 2); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (manageable, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 2); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 2); lymph node: 41.8 nTPM (protected, limit 2); spleen: 40.9 nTPM (manageable, limit 10); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 2); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 2); kidney: 33.1 nTPM (vital, limit 1); stomach: 32.7 nTPM (protected, limit 2); amygdala: 32.7 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 2); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (manageable, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); skin: 29.2 nTPM (manageable, limit 5); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); salivary gland: 25.7 nTPM (protected, limit 2); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000258289,CHURC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.8538% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 57.1279% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.5000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 65.3477% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 56.0123% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 74.6575% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.2985% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 57.4289% (minimum 99%, Baseline (adaptation disabled)); colon: 56.3017% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.8038% (minimum 99%, Baseline (adaptation disabled)); esophagus: 62.5000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 48.9228% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 63.8921% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 63.9671% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.2146% (minimum 99%, Baseline (adaptation disabled)); liver: 51.6098% (minimum 99%, Baseline (adaptation disabled)); lung: 65.7419% (minimum 99%, Baseline (adaptation disabled)); lymph node: 56.5940% (minimum 97%, Baseline (adaptation disabled)); midbrain: 59.3036% (minimum 99%, Baseline (adaptation disabled)); pancreas: 65.0358% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 55.2178% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.9001% (minimum 99%, Baseline (adaptation disabled)); rectum: 60.5556% (minimum 97%, Baseline (adaptation disabled)); retina: 60.3544% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 67.9551% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 40.5204% (minimum 99%, Baseline (adaptation disabled)); skin: 65.1135% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.0787% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 54.8290% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 52.6570% (minimum 99%, Baseline (adaptation disabled)); spleen: 57.1279% (minimum 95%, Baseline (adaptation disabled)); stomach: 62.5000% (minimum 97%, Baseline (adaptation disabled)); thymus: 47.9332% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 63.8921% (minimum 95%, Baseline (adaptation disabled)); tongue: 51.2700% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 59.5628% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,80,51.8,59.2,"skeletal muscle: 80 nTPM (vital, limit 1); thymus: 59.2 nTPM (manageable, limit 5); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 2); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (manageable, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 2); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 2); lymph node: 41.8 nTPM (protected, limit 2); spleen: 40.9 nTPM (manageable, limit 5); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 2); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 2); kidney: 33.1 nTPM (vital, limit 1); stomach: 32.7 nTPM (protected, limit 2); amygdala: 32.7 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 2); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (manageable, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); skin: 29.2 nTPM (manageable, limit 5); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); salivary gland: 25.7 nTPM (protected, limit 2); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000258289,CHURC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.470668,-0.4573,-0.584796
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.8538% (minimum 95%, Missing); adrenal gland: 57.1279% (minimum 99%, Missing); amygdala: 62.5000% (minimum 99%, Missing); basal ganglia: 65.3477% (minimum 99%, Missing); bone marrow: 56.0123% (minimum 99%, Missing); cerebellum: 74.6575% (minimum 99%, Missing); cerebral cortex: 63.2985% (minimum 99%, Missing); choroid plexus: 57.4289% (minimum 99%, Missing); colon: 56.3017% (minimum 97%, Missing); duodenum: 64.8038% (minimum 99%, Missing); esophagus: 62.5000% (minimum 97%, Missing); heart muscle: 48.9228% (minimum 99%, Missing); hippocampal formation: 63.8921% (minimum 99%, Missing); hypothalamus: 63.9671% (minimum 99%, Missing); kidney: 62.2146% (minimum 99%, Missing); liver: 51.6098% (minimum 99%, Missing); lung: 65.7419% (minimum 99%, Missing); lymph node: 56.5940% (minimum 97%, Missing); midbrain: 59.3036% (minimum 99%, Missing); pancreas: 65.0358% (minimum 99%, Missing); parathyroid gland: 55.2178% (minimum 97%, Missing); pituitary gland: 68.9001% (minimum 99%, Missing); rectum: 60.5556% (minimum 97%, Missing); retina: 60.3544% (minimum 99%, Missing); salivary gland: 67.9551% (minimum 97%, Missing); skeletal muscle: 40.5204% (minimum 99%, Missing); skin: 65.1135% (minimum 95%, Missing); small intestine: 63.0787% (minimum 99%, Missing); smooth muscle: 54.8290% (minimum 99%, Missing); spinal cord: 52.6570% (minimum 99%, Missing); spleen: 57.1279% (minimum 90%, Approved); stomach: 62.5000% (minimum 97%, Missing); thymus: 47.9332% (minimum 95%, Missing); thyroid gland: 63.8921% (minimum 95%, Missing); tongue: 51.2700% (minimum 97%, Missing); urinary bladder: 59.5628% (minimum 97%, Missing)",0,6,partial,80,51.8,59.2,"skeletal muscle: 80 nTPM (vital, limit 1); thymus: 59.2 nTPM (manageable, limit 5); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 2); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (manageable, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 2); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 2); lymph node: 41.8 nTPM (protected, limit 2); spleen: 40.9 nTPM (manageable, limit 10); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 2); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 2); kidney: 33.1 nTPM (vital, limit 1); stomach: 32.7 nTPM (protected, limit 2); amygdala: 32.7 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 2); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (manageable, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); skin: 29.2 nTPM (manageable, limit 5); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); salivary gland: 25.7 nTPM (protected, limit 2); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000258289,CHURC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.470668,-0.4573,-0.584796
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,14.5,8.3,7.6,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 2); urinary bladder: 6.3 nTPM (protected, limit 2); pancreas: 6 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); cerebral cortex: 5.9 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000258366,RTEL1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.1329% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 58.5366% (minimum 99%, Baseline (adaptation disabled)); amygdala: 83.4783% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 75.5906% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 64.8649% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 39.8340% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.9355% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 80.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 53.6313% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 68.0851% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 71.6418% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.6723% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 70.5882% (minimum 99%, Baseline (adaptation disabled)); liver: 67.1329% (minimum 99%, Baseline (adaptation disabled)); lung: 62.3377% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.0488% (minimum 97%, Baseline (adaptation disabled)); midbrain: 84.2105% (minimum 99%, Baseline (adaptation disabled)); pancreas: 61.5385% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.6723% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 44.6512% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.7196% (minimum 97%, Baseline (adaptation disabled)); retina: 86.4865% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 63.1579% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.0851% (minimum 99%, Baseline (adaptation disabled)); skin: 68.5714% (minimum 95%, Baseline (adaptation disabled)); small intestine: 62.7451% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.4865% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 82.7586% (minimum 99%, Baseline (adaptation disabled)); spleen: 61.9355% (minimum 95%, Baseline (adaptation disabled)); stomach: 60.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 74.4186% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 55.8140% (minimum 95%, Baseline (adaptation disabled)); tongue: 87.2727% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.3774% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,14.5,8.3,7.6,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 2); urinary bladder: 6.3 nTPM (protected, limit 2); pancreas: 6 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); cerebral cortex: 5.9 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000258366,RTEL1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.39186,-0.433687,-0.59166
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 67.1329% (minimum 95%, Missing); adrenal gland: 58.5366% (minimum 99%, Missing); amygdala: 83.4783% (minimum 99%, Missing); basal ganglia: 75.5906% (minimum 99%, Missing); bone marrow: 64.8649% (minimum 99%, Missing); cerebellum: 39.8340% (minimum 99%, Missing); cerebral cortex: 61.9355% (minimum 99%, Missing); choroid plexus: 80.0000% (minimum 99%, Missing); colon: 53.6313% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 68.0851% (minimum 97%, Missing); heart muscle: 71.6418% (minimum 99%, Missing); hippocampal formation: 80.6723% (minimum 99%, Missing); hypothalamus: 75.0000% (minimum 99%, Missing); kidney: 70.5882% (minimum 99%, Missing); liver: 67.1329% (minimum 99%, Missing); lung: 62.3377% (minimum 99%, Missing); lymph node: 78.0488% (minimum 97%, Missing); midbrain: 84.2105% (minimum 99%, Missing); pancreas: 61.5385% (minimum 99%, Missing); parathyroid gland: 80.6723% (minimum 97%, Missing); pituitary gland: 44.6512% (minimum 99%, Missing); rectum: 89.7196% (minimum 97%, Missing); retina: 86.4865% (minimum 99%, Missing); salivary gland: 63.1579% (minimum 97%, Missing); skeletal muscle: 68.0851% (minimum 99%, Missing); skin: 68.5714% (minimum 95%, Missing); small intestine: 62.7451% (minimum 99%, Missing); smooth muscle: 86.4865% (minimum 99%, Missing); spinal cord: 82.7586% (minimum 99%, Missing); spleen: 61.9355% (minimum 95%, Missing); stomach: 60.0000% (minimum 97%, Missing); thymus: 74.4186% (minimum 95%, Missing); thyroid gland: 55.8140% (minimum 95%, Missing); tongue: 87.2727% (minimum 97%, Missing); urinary bladder: 60.3774% (minimum 97%, Missing)",0,80,unavailable,14.5,8.3,7.6,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 2); thyroid gland: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 2); urinary bladder: 6.3 nTPM (protected, limit 2); pancreas: 6 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); cerebral cortex: 5.9 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 2); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 2); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); lymph node: 2.7 nTPM (protected, limit 2); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); parathyroid gland: 2.3 nTPM (protected, limit 2); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000258366,RTEL1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.39186,-0.433687,-0.59166
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,1,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000258405,ZNF578,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.8551% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 91.1765% (minimum 99%, Baseline (adaptation disabled)); amygdala: 95.3846% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 91.1765% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.5714% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.5373% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 81.5789% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 89.8551% (minimum 99%, Baseline (adaptation disabled)); colon: 92.5373% (minimum 97%, Baseline (adaptation disabled)); duodenum: 93.9394% (minimum 99%, Baseline (adaptation disabled)); esophagus: 93.9394% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 84.9315% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.3846% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.3846% (minimum 99%, Baseline (adaptation disabled)); kidney: 87.3239% (minimum 99%, Baseline (adaptation disabled)); liver: 95.3846% (minimum 99%, Baseline (adaptation disabled)); lung: 89.8551% (minimum 99%, Baseline (adaptation disabled)); lymph node: 89.8551% (minimum 97%, Baseline (adaptation disabled)); midbrain: 96.8750% (minimum 99%, Baseline (adaptation disabled)); pancreas: 89.8551% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 86.1111% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 95.3846% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.8551% (minimum 97%, Baseline (adaptation disabled)); retina: 68.1319% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 89.8551% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 87.3239% (minimum 99%, Baseline (adaptation disabled)); skin: 84.9315% (minimum 95%, Baseline (adaptation disabled)); small intestine: 93.9394% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.3239% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.9394% (minimum 99%, Baseline (adaptation disabled)); spleen: 83.7838% (minimum 95%, Baseline (adaptation disabled)); stomach: 91.1765% (minimum 97%, Baseline (adaptation disabled)); thymus: 86.1111% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 78.4810% (minimum 95%, Baseline (adaptation disabled)); tongue: 91.1765% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 92.5373% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,1,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000258405,ZNF578,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.16519,-0.108889,-0.308681
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 89.8551% (minimum 95%, Missing); adrenal gland: 91.1765% (minimum 99%, Missing); amygdala: 95.3846% (minimum 99%, Missing); basal ganglia: 91.1765% (minimum 99%, Missing); bone marrow: 88.5714% (minimum 99%, Missing); cerebellum: 92.5373% (minimum 99%, Missing); cerebral cortex: 81.5789% (minimum 99%, Missing); choroid plexus: 89.8551% (minimum 99%, Missing); colon: 92.5373% (minimum 97%, Missing); duodenum: 93.9394% (minimum 99%, Missing); esophagus: 93.9394% (minimum 97%, Missing); heart muscle: 84.9315% (minimum 99%, Missing); hippocampal formation: 95.3846% (minimum 99%, Missing); hypothalamus: 95.3846% (minimum 99%, Missing); kidney: 87.3239% (minimum 99%, Missing); liver: 95.3846% (minimum 99%, Missing); lung: 89.8551% (minimum 99%, Missing); lymph node: 89.8551% (minimum 97%, Missing); midbrain: 96.8750% (minimum 99%, Missing); pancreas: 89.8551% (minimum 99%, Missing); parathyroid gland: 86.1111% (minimum 97%, Missing); pituitary gland: 95.3846% (minimum 99%, Missing); rectum: 89.8551% (minimum 97%, Missing); retina: 68.1319% (minimum 99%, Missing); salivary gland: 89.8551% (minimum 97%, Missing); skeletal muscle: 87.3239% (minimum 99%, Missing); skin: 84.9315% (minimum 95%, Missing); small intestine: 93.9394% (minimum 99%, Missing); smooth muscle: 87.3239% (minimum 99%, Missing); spinal cord: 93.9394% (minimum 99%, Missing); spleen: 83.7838% (minimum 95%, Missing); stomach: 91.1765% (minimum 97%, Missing); thymus: 86.1111% (minimum 95%, Missing); thyroid gland: 78.4810% (minimum 95%, Missing); tongue: 91.1765% (minimum 97%, Missing); urinary bladder: 92.5373% (minimum 97%, Missing)",0,80,unavailable,2.9,1,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000258405,ZNF578,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.16519,-0.108889,-0.308681
True,compatible,,True,True,False,,0,4,partial,0.2,0,0,,,50,not_established,not_triggered,,,ENSG00000258436,RNASE12,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0.2,0,0,,,50,not_established,not_triggered,,,ENSG00000258436,RNASE12,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.00970562
True,compatible,,True,True,True,,0,4,partial,0.2,0,0,,,50,not_established,not_triggered,,,ENSG00000258436,RNASE12,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000258597,SERPINA2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000258597,SERPINA2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000258597,SERPINA2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,0,0.3,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000258713,C20orf141,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.7520% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.6,0,0.3,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000258713,C20orf141,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0476359,0.03,-0.0024805
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 98.7520% (minimum 99%, Missing)",0,80,unavailable,1.6,0,0.3,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000258713,C20orf141,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.0476359,0.03,-0.0024805
True,compatible,,True,True,False,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000258992,TSPY1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000258992,TSPY1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,ENSG00000258992,TSPY1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019;Wang 2016;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000259060,ENSG00000259060,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000259060,ENSG00000259060,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000259060,ENSG00000259060,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499,Wang 2016,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000259224,SLC35G6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.0392% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0392% (minimum 99%, Baseline (adaptation disabled)); retina: 98.0392% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 92.5926% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000259224,SLC35G6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,0.05,0.03,-0.0640741
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 98.0392% (minimum 99%, Missing); cerebellum: 98.0392% (minimum 99%, Missing); retina: 98.0392% (minimum 99%, Missing); skeletal muscle: 92.5926% (minimum 99%, Missing)",0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,ENSG00000259224,SLC35G6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1136/jitc-2023-007935,Carter 2023,0.05,0.03,-0.0640741
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,False,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000259316,ENSG00000259316,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000259316,ENSG00000259316,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000259316,ENSG00000259316,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000259571,BLID,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"choroid plexus: 33.3333% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 50.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000259571,BLID,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.656667
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence,False,False,True,"choroid plexus: 33.3333% (minimum 99%, Missing); heart muscle: 50.0000% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000259571,BLID,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.656667
True,compatible,,True,True,False,,0,80,unavailable,1,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000260286,ARMH2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 92.8571% (minimum 99%, Baseline (adaptation disabled)); lung: 92.8571% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000260286,ARMH2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.00588235,0.0148485,-0.0614286
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 92.8571% (minimum 99%, Missing); lung: 92.8571% (minimum 99%, Missing)",0,80,unavailable,1,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000260286,ARMH2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.00588235,0.0148485,-0.0614286
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,False,,0,2,partial,2.7,1.2,1.4,"kidney: 2.7 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000260287,TBC1D3G,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 96.9466% (minimum 99%, Baseline (adaptation disabled)); amygdala: 97.3180% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.5779% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3636% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 95.8491% (minimum 99%, Baseline (adaptation disabled)); esophagus: 95.4887% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 98.0695% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 95.8491% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 97.3180% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.3915% (minimum 99%, Baseline (adaptation disabled)); liver: 95.4887% (minimum 99%, Baseline (adaptation disabled)); lung: 97.6923% (minimum 99%, Baseline (adaptation disabled)); midbrain: 97.6923% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.6923% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.5779% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 98.0695% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.6923% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 97.3180% (minimum 99%, Baseline (adaptation disabled)); spleen: 94.7761% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 95.4887% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,2.7,1.2,1.4,"kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000260287,TBC1D3G,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.00223881,-0.0151128,-0.0860854
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 96.9466% (minimum 97%, Supported); amygdala: 97.3180% (minimum 99%, Missing); basal ganglia: 96.5779% (minimum 99%, Missing); cerebellum: 92.3636% (minimum 97%, Supported); cerebral cortex: 95.8491% (minimum 97%, Supported); hippocampal formation: 95.8491% (minimum 99%, Missing); hypothalamus: 97.3180% (minimum 99%, Missing); kidney: 90.3915% (minimum 99%, Missing); liver: 95.4887% (minimum 97%, Supported); midbrain: 97.6923% (minimum 99%, Missing); pituitary gland: 96.5779% (minimum 99%, Missing); spinal cord: 97.3180% (minimum 99%, Missing)",0,2,partial,2.7,1.2,1.4,"kidney: 2.7 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000260287,TBC1D3G,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.010695,-0.0860854
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,10,partial,6.8,3,2.4,"liver: 6.8 nTPM (vital, limit 3); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 3); cerebral cortex: 4.1 nTPM (vital, limit 3); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 3); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000260456,C16orf95,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.3832% (minimum 99%, Baseline (adaptation disabled)); amygdala: 96.1951% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.6667% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 96.7615% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.7976% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.0078% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.6000% (minimum 99%, Baseline (adaptation disabled)); duodenum: 98.6000% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.5272% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 96.9518% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.9518% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.4308% (minimum 99%, Baseline (adaptation disabled)); liver: 93.5484% (minimum 99%, Baseline (adaptation disabled)); lung: 98.7976% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.8212% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.9518% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.8175% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 95.9144% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.5015% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 96.9518% (minimum 99%, Baseline (adaptation disabled))",0,10,partial,6.8,3,2.4,"liver: 6.8 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); kidney: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); stomach: 2.1 nTPM (protected, limit 2); small intestine: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000260456,C16orf95,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0262376,0.000472441,-0.0545161
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 96.3832% (minimum 97%, Supported); amygdala: 96.1951% (minimum 99%, Missing); basal ganglia: 96.6667% (minimum 99%, Missing); bone marrow: 96.7615% (minimum 97%, Supported); cerebral cortex: 96.0078% (minimum 97%, Supported); choroid plexus: 98.6000% (minimum 99%, Missing); duodenum: 98.6000% (minimum 99%, Missing); hippocampal formation: 96.9518% (minimum 99%, Missing); hypothalamus: 96.9518% (minimum 99%, Missing); liver: 93.5484% (minimum 97%, Supported); midbrain: 95.8212% (minimum 99%, Missing); pancreas: 96.9518% (minimum 97%, Supported); pituitary gland: 97.8175% (minimum 99%, Missing); skeletal muscle: 95.9144% (minimum 97%, Supported); small intestine: 98.5015% (minimum 99%, Missing); spinal cord: 96.9518% (minimum 99%, Missing)",0,10,partial,6.8,3,2.4,"liver: 6.8 nTPM (vital, limit 3); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 3); cerebral cortex: 4.1 nTPM (vital, limit 3); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 3); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); tongue: 3 nTPM (protected, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000260456,C16orf95,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223,Chang 2019,0.0330508,0.000472441,-0.0345161
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; thymus,ENSG00000260596,DUX4,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adrenal gland: 90.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.0000% (minimum 99%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 90.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 90.0000% (minimum 97%, Baseline (adaptation disabled)); pancreas: 90.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 81.8182% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 90.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 90.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 90.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 90.0000% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; thymus,ENSG00000260596,DUX4,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.05,-0.151818,-0.24
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adrenal gland: 90.0000% (minimum 99%, Missing); cerebral cortex: 90.0000% (minimum 99%, Missing); duodenum: 75.0000% (minimum 99%, Missing); lung: 90.0000% (minimum 99%, Missing); lymph node: 90.0000% (minimum 97%, Missing); pancreas: 90.0000% (minimum 99%, Missing); salivary gland: 81.8182% (minimum 97%, Missing); skeletal muscle: 90.0000% (minimum 99%, Missing); skin: 90.0000% (minimum 95%, Missing); stomach: 90.0000% (minimum 97%, Missing); thymus: 90.0000% (minimum 95%, Missing)",0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; thymus,ENSG00000260596,DUX4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.05,-0.151818,-0.24
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000260734,TLE7,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000260734,TLE7,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000260734,TLE7,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.8,0.3,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000261341,SMIM47,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.8,0.3,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000261341,SMIM47,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0102558,0.0285748,0.00620853
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0.8,0.3,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000261341,SMIM47,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0102558,0.0285748,0.00620853
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000261509,TP53TG3B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 97.7273% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000261509,TP53TG3B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.0127273
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 97.7273% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000261509,TP53TG3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017,0.05,0.03,-0.0127273
True,compatible,,True,True,False,,0,80,unavailable,0.4,0,0.1,,,0,not_established,not_triggered,,,ENSG00000261649,GOLGA6L7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.5401% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.4,0,0.1,,,0,not_established,not_triggered,,,ENSG00000261649,GOLGA6L7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,0.04631,0.03,-0.00459854
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 98.5401% (minimum 99%, Missing)",0,80,unavailable,0.4,0,0.1,,,0,not_established,not_triggered,,,ENSG00000261649,GOLGA6L7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,0.04631,0.03,-0.00459854
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,ENSG00000261739,GOLGA8S,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 94.2857% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 89.1892% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 91.6667% (minimum 99%, Baseline (adaptation disabled)); duodenum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 94.2857% (minimum 99%, Baseline (adaptation disabled)); pancreas: 82.5000% (minimum 99%, Baseline (adaptation disabled)); retina: 94.2857% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.0588% (minimum 99%, Baseline (adaptation disabled)); stomach: 94.2857% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,ENSG00000261739,GOLGA8S,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,-0.00714286,-0.0271429,-0.165
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 94.2857% (minimum 95%, Missing); bone marrow: 89.1892% (minimum 99%, Missing); cerebral cortex: 91.6667% (minimum 99%, Missing); duodenum: 91.6667% (minimum 99%, Missing); heart muscle: 94.2857% (minimum 99%, Missing); pancreas: 82.5000% (minimum 99%, Missing); retina: 94.2857% (minimum 99%, Missing); small intestine: 97.0588% (minimum 99%, Missing); stomach: 94.2857% (minimum 97%, Missing)",0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,ENSG00000261739,GOLGA8S,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,-0.00714286,-0.0271429,-0.165
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,10.5,0,0.1,"retina: 10.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000261873,SMIM36,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"bone marrow: 96.4286% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.4286% (minimum 99%, Baseline (adaptation disabled)); retina: 20.4545% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,10.5,0,0.1,"retina: 10.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000261873,SMIM36,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0142857,0.03,-0.785455
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"bone marrow: 96.4286% (minimum 99%, Missing); cerebral cortex: 96.4286% (minimum 99%, Missing); retina: 20.4545% (minimum 99%, Missing)",0,80,unavailable,10.5,0,0.1,"retina: 10.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,ENSG00000261873,SMIM36,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0142857,0.03,-0.785455
True,compatible,,True,True,False,,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000261949,GFY,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 72.2222% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 92.8571% (minimum 99%, Baseline (adaptation disabled)); retina: 68.4211% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000261949,GFY,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.05,0.03,-0.305789
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 72.2222% (minimum 99%, Missing); cerebral cortex: 92.8571% (minimum 99%, Missing); retina: 68.4211% (minimum 99%, Missing)",0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,ENSG00000261949,GFY,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.05,0.03,-0.305789
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,68.7,23.7,55.2,"bone marrow: 68.7 nTPM (vital, limit 1); spleen: 55.2 nTPM (manageable, limit 5); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 2); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 2); cerebral cortex: 17.5 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); stomach: 14.9 nTPM (protected, limit 2); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 2); thyroid gland: 14 nTPM (manageable, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 2); cerebellum: 12.4 nTPM (vital, limit 1); skin: 11.3 nTPM (manageable, limit 5); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 2); thymus: 10.6 nTPM (manageable, limit 5); pancreas: 10.5 nTPM (vital, limit 1); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); parathyroid gland: 4.4 nTPM (protected, limit 2); retina: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000262246,CORO7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 64.0288% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 63.5714% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.9259% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 52.5591% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 27.9874% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 68.2864% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 60.4072% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 81.4024% (minimum 99%, Baseline (adaptation disabled)); colon: 57.4194% (minimum 97%, Baseline (adaptation disabled)); duodenum: 64.4928% (minimum 99%, Baseline (adaptation disabled)); esophagus: 71.5818% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.2632% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 56.4482% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.2544% (minimum 99%, Baseline (adaptation disabled)); kidney: 63.8756% (minimum 99%, Baseline (adaptation disabled)); liver: 75.6374% (minimum 99%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 52.9762% (minimum 97%, Baseline (adaptation disabled)); midbrain: 63.2701% (minimum 99%, Baseline (adaptation disabled)); pancreas: 71.7742% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 85.8521% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 67.0854% (minimum 99%, Baseline (adaptation disabled)); rectum: 85.5769% (minimum 97%, Baseline (adaptation disabled)); retina: 95.0178% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 67.2544% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 81.1550% (minimum 99%, Baseline (adaptation disabled)); skin: 70.2632% (minimum 95%, Baseline (adaptation disabled)); small intestine: 46.9244% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 83.4375% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 56.8085% (minimum 99%, Baseline (adaptation disabled)); spleen: 32.6007% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.1827% (minimum 97%, Baseline (adaptation disabled)); thymus: 71.5818% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 65.6020% (minimum 95%, Baseline (adaptation disabled)); tongue: 94.3463% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.4412% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,68.7,23.7,55.2,"bone marrow: 68.7 nTPM (vital, limit 1); spleen: 55.2 nTPM (manageable, limit 5); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 2); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 2); cerebral cortex: 17.5 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); stomach: 14.9 nTPM (protected, limit 2); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 2); thyroid gland: 14 nTPM (manageable, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 2); cerebellum: 12.4 nTPM (vital, limit 1); skin: 11.3 nTPM (manageable, limit 5); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 2); thymus: 10.6 nTPM (manageable, limit 5); pancreas: 10.5 nTPM (vital, limit 1); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); parathyroid gland: 4.4 nTPM (protected, limit 2); retina: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000262246,CORO7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.623993,-0.440238,-0.710126
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 64.0288% (minimum 95%, Uncertain); adrenal gland: 63.5714% (minimum 99%, Uncertain); amygdala: 65.9259% (minimum 99%, Missing); basal ganglia: 52.5591% (minimum 99%, Missing); bone marrow: 27.9874% (minimum 99%, Missing); cerebellum: 68.2864% (minimum 99%, Uncertain); cerebral cortex: 60.4072% (minimum 99%, Uncertain); choroid plexus: 81.4024% (minimum 99%, Missing); colon: 57.4194% (minimum 97%, Missing); duodenum: 64.4928% (minimum 99%, Missing); esophagus: 71.5818% (minimum 97%, Uncertain); heart muscle: 70.2632% (minimum 99%, Uncertain); hippocampal formation: 56.4482% (minimum 99%, Missing); hypothalamus: 67.2544% (minimum 99%, Missing); kidney: 63.8756% (minimum 99%, Missing); liver: 75.6374% (minimum 99%, Uncertain); lung: 50.0000% (minimum 99%, Missing); lymph node: 52.9762% (minimum 97%, Missing); midbrain: 63.2701% (minimum 99%, Missing); pancreas: 71.7742% (minimum 99%, Missing); parathyroid gland: 85.8521% (minimum 97%, Uncertain); pituitary gland: 67.0854% (minimum 99%, Missing); rectum: 85.5769% (minimum 97%, Missing); retina: 95.0178% (minimum 99%, Missing); salivary gland: 67.2544% (minimum 97%, Uncertain); skeletal muscle: 81.1550% (minimum 99%, Missing); skin: 70.2632% (minimum 95%, Missing); small intestine: 46.9244% (minimum 99%, Missing); smooth muscle: 83.4375% (minimum 99%, Missing); spinal cord: 56.8085% (minimum 99%, Missing); spleen: 32.6007% (minimum 95%, Missing); stomach: 64.1827% (minimum 97%, Missing); thymus: 71.5818% (minimum 95%, Missing); thyroid gland: 65.6020% (minimum 95%, Uncertain); tongue: 94.3463% (minimum 97%, Missing); urinary bladder: 65.4412% (minimum 97%, Uncertain)",0,2,partial,68.7,23.7,55.2,"bone marrow: 68.7 nTPM (vital, limit 1); spleen: 55.2 nTPM (manageable, limit 5); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 2); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 2); cerebral cortex: 17.5 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); stomach: 14.9 nTPM (protected, limit 2); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 2); thyroid gland: 14 nTPM (manageable, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 2); cerebellum: 12.4 nTPM (vital, limit 1); skin: 11.3 nTPM (manageable, limit 5); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 2); thymus: 10.6 nTPM (manageable, limit 5); pancreas: 10.5 nTPM (vital, limit 1); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 2); parathyroid gland: 4.4 nTPM (protected, limit 2); retina: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000262246,CORO7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.623993,-0.440238,-0.710126
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.3,2.2,1.7,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000262576,PCDHGA4,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.8750% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 53.5714% (minimum 99%, Baseline (adaptation disabled)); amygdala: 50.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 40.5405% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 44.1176% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 31.2500% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 65.2174% (minimum 97%, Baseline (adaptation disabled)); duodenum: 88.2353% (minimum 99%, Baseline (adaptation disabled)); esophagus: 78.9474% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 51.7241% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 55.5556% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 55.5556% (minimum 99%, Baseline (adaptation disabled)); kidney: 78.9474% (minimum 99%, Baseline (adaptation disabled)); liver: 83.3333% (minimum 99%, Baseline (adaptation disabled)); lung: 60.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 93.7500% (minimum 97%, Baseline (adaptation disabled)); midbrain: 57.6923% (minimum 99%, Baseline (adaptation disabled)); pancreas: 42.8571% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 40.5405% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 60.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 83.3333% (minimum 97%, Baseline (adaptation disabled)); retina: 50.0000% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 68.1818% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 68.1818% (minimum 99%, Baseline (adaptation disabled)); skin: 75.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 83.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 51.7241% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 53.5714% (minimum 99%, Baseline (adaptation disabled)); spleen: 88.2353% (minimum 95%, Baseline (adaptation disabled)); stomach: 78.9474% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.2353% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 71.4286% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.5000% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 68.1818% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.3,2.2,1.7,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000262576,PCDHGA4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.48125,-0.564595,-0.6775
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.8750% (minimum 95%, Missing); adrenal gland: 53.5714% (minimum 99%, Missing); amygdala: 50.0000% (minimum 99%, Missing); basal ganglia: 40.5405% (minimum 99%, Missing); cerebellum: 44.1176% (minimum 99%, Missing); cerebral cortex: 31.2500% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 65.2174% (minimum 97%, Missing); duodenum: 88.2353% (minimum 99%, Missing); esophagus: 78.9474% (minimum 97%, Missing); heart muscle: 51.7241% (minimum 99%, Missing); hippocampal formation: 55.5556% (minimum 99%, Missing); hypothalamus: 55.5556% (minimum 99%, Missing); kidney: 78.9474% (minimum 99%, Missing); liver: 83.3333% (minimum 99%, Missing); lung: 60.0000% (minimum 99%, Missing); lymph node: 93.7500% (minimum 97%, Missing); midbrain: 57.6923% (minimum 99%, Missing); pancreas: 42.8571% (minimum 99%, Missing); parathyroid gland: 40.5405% (minimum 97%, Missing); pituitary gland: 60.0000% (minimum 99%, Missing); rectum: 83.3333% (minimum 97%, Missing); retina: 50.0000% (minimum 99%, Missing); salivary gland: 68.1818% (minimum 97%, Missing); skeletal muscle: 68.1818% (minimum 99%, Missing); skin: 75.0000% (minimum 95%, Missing); small intestine: 83.3333% (minimum 99%, Missing); smooth muscle: 51.7241% (minimum 99%, Missing); spinal cord: 53.5714% (minimum 99%, Missing); spleen: 88.2353% (minimum 95%, Missing); stomach: 78.9474% (minimum 97%, Missing); thymus: 88.2353% (minimum 95%, Missing); thyroid gland: 71.4286% (minimum 95%, Missing); tongue: 62.5000% (minimum 97%, Missing); urinary bladder: 68.1818% (minimum 97%, Missing)",0,80,unavailable,3.3,2.2,1.7,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); parathyroid gland: 2.2 nTPM (protected, limit 2); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000262576,PCDHGA4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.48125,-0.564595,-0.6775
False,excluded,positive_ihc_outside_permitted,True,True,False,,0,1,partial,0.6,0.2,0.4,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000262874,C19orf84,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"bone marrow: 97.2727% (minimum 99%, Baseline (adaptation disabled))",0,1,partial,0.6,0.2,0.4,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000262874,C19orf84,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0316514,0.0207407,-0.0172727
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"bone marrow: 97.2727% (minimum 99%, Uncertain)",0,1,partial,0.6,0.2,0.4,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,ENSG00000262874,C19orf84,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019;Gong 2021;da Silva 2017,0.0316514,0.0207407,-0.0172727
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000266826,IGBP1C,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000266826,IGBP1C,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000266826,IGBP1C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,False,,0,2,partial,4.1,0,0,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 2)",pituitary gland / cells in anterior : High (Approved),54,not_established,not_triggered,,,ENSG00000267631,CGB1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 60.0000% (minimum 99%, Baseline (adaptation disabled)); pancreas: 10.3448% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 6.8182% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,4.1,0,0,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Approved),54,not_established,not_triggered,,,ENSG00000267631,CGB1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.921818
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 60.0000% (minimum 98%, Approved); pancreas: 10.3448% (minimum 98%, Approved); pituitary gland: 6.8182% (minimum 99%, Missing)",0,2,partial,4.1,0,0,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 2)",pituitary gland / cells in anterior : High (Approved),54,not_established,not_triggered,,,ENSG00000267631,CGB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,-0.921818
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,6,partial,237,232.8,41,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 2); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 2); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 2); stomach: 53.2 nTPM (protected, limit 2); colon: 45.2 nTPM (protected, limit 2); spinal cord: 43.9 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 2); spleen: 41 nTPM (manageable, limit 5); thyroid gland: 40.1 nTPM (manageable, limit 5); thymus: 39.7 nTPM (manageable, limit 5); adipose tissue: 38.2 nTPM (manageable, limit 30); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 2); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 2); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); lymph node: 28.8 nTPM (protected, limit 2); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 1 / vascular mural cells: Low (Enhanced); skin 2 / arrector pili muscle cells: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); skin 2 / vascular mural cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / arrector pili muscle cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / sebaceous glands; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000267855,NDUFA7,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.8831% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 38.2374% (minimum 99%, Baseline (adaptation disabled)); amygdala: 39.5331% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 37.9061% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 60.9049% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 58.7248% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 42.3387% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 23.0871% (minimum 99%, Baseline (adaptation disabled)); colon: 53.7359% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.1700% (minimum 99%, Baseline (adaptation disabled)); esophagus: 48.3871% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 24.3959% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 46.1741% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 45.6919% (minimum 99%, Baseline (adaptation disabled)); kidney: 37.9335% (minimum 99%, Baseline (adaptation disabled)); liver: 39.2084% (minimum 99%, Baseline (adaptation disabled)); lung: 63.5593% (minimum 99%, Baseline (adaptation disabled)); lymph node: 64.5756% (minimum 97%, Baseline (adaptation disabled)); midbrain: 40.3536% (minimum 99%, Baseline (adaptation disabled)); pancreas: 59.3891% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 34.5168% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 38.4334% (minimum 99%, Baseline (adaptation disabled)); rectum: 61.8375% (minimum 97%, Baseline (adaptation disabled)); retina: 62.7240% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 55.4382% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 18.1347% (minimum 99%, Baseline (adaptation disabled)); skin: 63.7910% (minimum 95%, Baseline (adaptation disabled)); small intestine: 61.4035% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 70.5645% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 54.4606% (minimum 99%, Baseline (adaptation disabled)); spleen: 56.1497% (minimum 95%, Baseline (adaptation disabled)); stomach: 49.6689% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.9414% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 56.6955% (minimum 95%, Baseline (adaptation disabled)); tongue: 18.4017% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 60.4143% (minimum 97%, Baseline (adaptation disabled))",0,6,partial,237,232.8,41,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 2); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 2); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 2); stomach: 53.2 nTPM (protected, limit 2); colon: 45.2 nTPM (protected, limit 2); spinal cord: 43.9 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 2); spleen: 41 nTPM (manageable, limit 5); thyroid gland: 40.1 nTPM (manageable, limit 5); thymus: 39.7 nTPM (manageable, limit 5); adipose tissue: 38.2 nTPM (manageable, limit 5); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 2); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 2); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); lymph node: 28.8 nTPM (protected, limit 2); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 1 / vascular mural cells: Low (Enhanced); skin 2 / arrector pili muscle cells: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); skin 2 / vascular mural cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / arrector pili muscle cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / sebaceous glands; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000267855,NDUFA7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.388503,-0.785983,-0.808653
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.8831% (minimum 60%, Enhanced); adrenal gland: 38.2374% (minimum 99%, Missing); amygdala: 39.5331% (minimum 99%, Missing); basal ganglia: 37.9061% (minimum 99%, Missing); bone marrow: 60.9049% (minimum 99%, Missing); cerebellum: 58.7248% (minimum 99%, Missing); cerebral cortex: 42.3387% (minimum 99%, Missing); choroid plexus: 23.0871% (minimum 99%, Missing); colon: 53.7359% (minimum 97%, Missing); duodenum: 69.1700% (minimum 99%, Missing); esophagus: 48.3871% (minimum 97%, Missing); heart muscle: 24.3959% (minimum 99%, Missing); hippocampal formation: 46.1741% (minimum 99%, Missing); hypothalamus: 45.6919% (minimum 99%, Missing); kidney: 37.9335% (minimum 99%, Missing); liver: 39.2084% (minimum 99%, Missing); lung: 63.5593% (minimum 99%, Missing); lymph node: 64.5756% (minimum 97%, Missing); midbrain: 40.3536% (minimum 99%, Missing); pancreas: 59.3891% (minimum 99%, Missing); parathyroid gland: 34.5168% (minimum 97%, Missing); pituitary gland: 38.4334% (minimum 99%, Missing); rectum: 61.8375% (minimum 97%, Missing); retina: 62.7240% (minimum 99%, Missing); salivary gland: 55.4382% (minimum 97%, Missing); skeletal muscle: 18.1347% (minimum 99%, Missing); skin: 63.7910% (minimum 95%, Missing); small intestine: 61.4035% (minimum 99%, Missing); smooth muscle: 70.5645% (minimum 99%, Missing); spinal cord: 54.4606% (minimum 99%, Missing); spleen: 56.1497% (minimum 95%, Missing); stomach: 49.6689% (minimum 97%, Missing); thymus: 56.9414% (minimum 95%, Missing); thyroid gland: 56.6955% (minimum 95%, Missing); tongue: 18.4017% (minimum 97%, Missing); urinary bladder: 60.4143% (minimum 97%, Missing)",0,6,partial,237,232.8,41,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 2); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 2); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 2); stomach: 53.2 nTPM (protected, limit 2); colon: 45.2 nTPM (protected, limit 2); spinal cord: 43.9 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 2); spleen: 41 nTPM (manageable, limit 5); thyroid gland: 40.1 nTPM (manageable, limit 5); thymus: 39.7 nTPM (manageable, limit 5); adipose tissue: 38.2 nTPM (manageable, limit 30); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 2); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 2); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); lymph node: 28.8 nTPM (protected, limit 2); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 1 / vascular mural cells: Low (Enhanced); skin 2 / arrector pili muscle cells: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); skin 2 / vascular mural cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / arrector pili muscle cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / sebaceous glands; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000267855,NDUFA7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.388503,-0.785983,-0.808653
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,ENSG00000267978,MAGEA9B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.9796% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,ENSG00000267978,MAGEA9B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,0.029798,0.0197959,-0.000204082
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.9796% (minimum 99%, Missing)",0,80,unavailable,0.1,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,ENSG00000267978,MAGEA9B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,0.029798,0.0197959,-0.000204082
True,compatible,,True,True,False,,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,ENSG00000268009,SSX4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 93.9394% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.8750% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 96.8750% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,ENSG00000268009,SSX4,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,-0.00125,-0.0506061
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 93.9394% (minimum 99%, Missing); heart muscle: 96.8750% (minimum 97%, Supported)",0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,ENSG00000268009,SSX4,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.03,-0.0506061
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000268223,ARL14EPL,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adipose tissue: 66.6667% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 40.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 66.6667% (minimum 99%, Baseline (adaptation disabled)); lung: 50.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); spleen: 66.6667% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000268223,ARL14EPL,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,-0.47,-0.59
False,excluded,reproductive_selectivity_below_threshold;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,"adipose tissue: 66.6667% (minimum 95%, Missing); bone marrow: 40.0000% (minimum 99%, Missing); kidney: 66.6667% (minimum 99%, Missing); lung: 50.0000% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); spleen: 66.6667% (minimum 95%, Missing)",0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,ENSG00000268223,ARL14EPL,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.283333,-0.47,-0.59
True,compatible,,True,True,False,,0,2,partial,0.1,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000268447,SSX2B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.1,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000268447,SSX2B,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.0321429,0.03,0.0039759
True,compatible,,True,True,True,,0,2,partial,0.1,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000268447,SSX2B,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.0039759
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,False,,9,80,unavailable,0.8,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000268480,NFILZ,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 94.1176% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 66.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.1176% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.8889% (minimum 99%, Baseline (adaptation disabled)); colon: 94.1176% (minimum 97%, Baseline (adaptation disabled)); duodenum: 94.1176% (minimum 99%, Baseline (adaptation disabled)); esophagus: 94.1176% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); kidney: 88.8889% (minimum 99%, Baseline (adaptation disabled)); liver: 88.8889% (minimum 99%, Baseline (adaptation disabled)); lung: 88.8889% (minimum 99%, Baseline (adaptation disabled)); lymph node: 84.2105% (minimum 97%, Baseline (adaptation disabled)); rectum: 94.1176% (minimum 97%, Baseline (adaptation disabled)); retina: 76.1905% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.1176% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 80.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 80.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 94.1176% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.1176% (minimum 99%, Baseline (adaptation disabled)); spleen: 84.2105% (minimum 95%, Baseline (adaptation disabled)); stomach: 88.8889% (minimum 97%, Baseline (adaptation disabled)); thymus: 88.8889% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 94.1176% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 94.1176% (minimum 97%, Baseline (adaptation disabled))",9,80,unavailable,0.8,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000268480,NFILZ,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,-0.15,-0.127895,-0.323333
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 94.1176% (minimum 95%, Missing); bone marrow: 66.6667% (minimum 99%, Missing); cerebral cortex: 94.1176% (minimum 99%, Missing); choroid plexus: 88.8889% (minimum 99%, Missing); colon: 94.1176% (minimum 97%, Missing); duodenum: 94.1176% (minimum 99%, Missing); esophagus: 94.1176% (minimum 97%, Missing); heart muscle: 94.1176% (minimum 99%, Missing); kidney: 88.8889% (minimum 99%, Missing); liver: 88.8889% (minimum 99%, Missing); lung: 88.8889% (minimum 99%, Missing); lymph node: 84.2105% (minimum 97%, Missing); rectum: 94.1176% (minimum 97%, Missing); retina: 76.1905% (minimum 99%, Missing); salivary gland: 94.1176% (minimum 97%, Missing); skeletal muscle: 80.0000% (minimum 99%, Missing); skin: 80.0000% (minimum 95%, Missing); small intestine: 94.1176% (minimum 99%, Missing); smooth muscle: 94.1176% (minimum 99%, Missing); spleen: 84.2105% (minimum 95%, Missing); stomach: 88.8889% (minimum 97%, Missing); thymus: 88.8889% (minimum 95%, Missing); thyroid gland: 94.1176% (minimum 95%, Missing); urinary bladder: 94.1176% (minimum 97%, Missing)",9,80,unavailable,0.8,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000268480,NFILZ,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,-0.15,-0.127895,-0.323333
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000268606,MAGEA2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000268606,MAGEA2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000268606,MAGEA2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000268629,TEX13A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000268629,TEX13A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000268629,TEX13A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,4,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000268651,CTAG1A,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,,,
True,compatible,,True,True,True,,0,4,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000268651,CTAG1A,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.0378049,0.03,0.01
True,compatible,,True,True,True,,0,4,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000268651,CTAG1A,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna,True,True,False,,9,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,ENSG00000268696,ZNF723,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna,True,True,True,"bone marrow: 97.0588% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.0588% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 94.2857% (minimum 97%, Baseline (adaptation disabled))",9,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,ENSG00000268696,ZNF723,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.05,-0.0271429,-0.0194118
False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna,True,True,True,"bone marrow: 97.0588% (minimum 99%, Missing); pancreas: 97.0588% (minimum 99%, Missing); parathyroid gland: 94.2857% (minimum 97%, Missing)",9,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,ENSG00000268696,ZNF723,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.05,-0.0271429,-0.0194118
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,1.7,2,1.1,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000268738,HSFX2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 97.5610% (minimum 99%, Baseline (adaptation disabled)); amygdala: 90.9091% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.5912% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 92.3077% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 88.8889% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 88.2353% (minimum 99%, Baseline (adaptation disabled)); colon: 95.2381% (minimum 97%, Baseline (adaptation disabled)); duodenum: 96.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.7742% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 90.9091% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 88.2353% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 92.3077% (minimum 99%, Baseline (adaptation disabled)); kidney: 96.0000% (minimum 99%, Baseline (adaptation disabled)); liver: 96.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 96.0000% (minimum 99%, Baseline (adaptation disabled)); midbrain: 92.3077% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.7742% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 90.9091% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 96.7742% (minimum 99%, Baseline (adaptation disabled)); rectum: 96.7742% (minimum 97%, Baseline (adaptation disabled)); retina: 92.3077% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 93.0233% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 94.4882% (minimum 99%, Baseline (adaptation disabled)); skin: 91.6031% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.5610% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.4882% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.2381% (minimum 99%, Baseline (adaptation disabled)); spleen: 91.6031% (minimum 95%, Baseline (adaptation disabled)); stomach: 96.7742% (minimum 97%, Baseline (adaptation disabled)); tongue: 85.7143% (minimum 97%, Baseline (adaptation disabled))",0,3,partial,1.7,2,1.1,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000268738,HSFX2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.0339695,-0.112857,-0.114088
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 90.9091% (minimum 99%, Missing); basal ganglia: 87.5912% (minimum 99%, Missing); cerebellum: 92.3077% (minimum 97%, Supported); cerebral cortex: 88.8889% (minimum 97%, Supported); choroid plexus: 88.2353% (minimum 99%, Missing); duodenum: 96.0000% (minimum 97%, Supported); heart muscle: 90.9091% (minimum 97%, Supported); hippocampal formation: 88.2353% (minimum 99%, Missing); hypothalamus: 92.3077% (minimum 99%, Missing); kidney: 96.0000% (minimum 97%, Supported); liver: 96.0000% (minimum 97%, Supported); lung: 96.0000% (minimum 97%, Supported); midbrain: 92.3077% (minimum 99%, Missing); pancreas: 96.7742% (minimum 97%, Supported); pituitary gland: 96.7742% (minimum 99%, Missing); retina: 92.3077% (minimum 99%, Missing); skeletal muscle: 94.4882% (minimum 97%, Supported); smooth muscle: 94.4882% (minimum 97%, Supported); spinal cord: 95.2381% (minimum 99%, Missing); tongue: 85.7143% (minimum 97%, Missing)",0,3,partial,1.7,2,1.1,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000268738,HSFX2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.01,-0.112857,-0.114088
True,compatible,,True,True,False,,0,80,unavailable,0.1,1,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,ENSG00000268902,CSAG2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 90.9091% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 90.9091% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.9091% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.9091% (minimum 99%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.9091% (minimum 99%, Baseline (adaptation disabled)); skin: 58.8235% (minimum 95%, Baseline (adaptation disabled)); spinal cord: 90.9091% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.5000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 90.9091% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,0.1,1,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,ENSG00000268902,CSAG2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.361765,-0.47,-0.0809091
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 90.9091% (minimum 99%, Missing); hippocampal formation: 90.9091% (minimum 99%, Missing); hypothalamus: 90.9091% (minimum 99%, Missing); kidney: 90.9091% (minimum 99%, Missing); lymph node: 50.0000% (minimum 97%, Missing); midbrain: 90.9091% (minimum 99%, Missing); skin: 58.8235% (minimum 95%, Missing); spinal cord: 90.9091% (minimum 99%, Missing); spleen: 62.5000% (minimum 95%, Missing); urinary bladder: 90.9091% (minimum 97%, Missing)",0,80,unavailable,0.1,1,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,ENSG00000268902,CSAG2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.361765,-0.47,-0.0809091
True,compatible,,True,True,False,,0,80,unavailable,0.4,1.3,2.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus; tonsil,ENSG00000268916,CSAG3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 95.0000% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 95.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.4359% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 92.6829% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.0000% (minimum 99%, Baseline (adaptation disabled)); kidney: 92.6829% (minimum 99%, Baseline (adaptation disabled)); liver: 97.4359% (minimum 99%, Baseline (adaptation disabled)); lung: 97.4359% (minimum 99%, Baseline (adaptation disabled)); lymph node: 74.5098% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.4762% (minimum 99%, Baseline (adaptation disabled)); skin: 80.8511% (minimum 95%, Baseline (adaptation disabled)); small intestine: 97.4359% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 95.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.3333% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,0.4,1.3,2.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus; tonsil,ENSG00000268916,CSAG3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.316667,-0.224902,-0.0852381
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 95.0000% (minimum 99%, Missing); basal ganglia: 95.0000% (minimum 99%, Missing); cerebral cortex: 97.4359% (minimum 99%, Missing); hippocampal formation: 92.6829% (minimum 99%, Missing); hypothalamus: 95.0000% (minimum 99%, Missing); kidney: 92.6829% (minimum 99%, Missing); liver: 97.4359% (minimum 99%, Missing); lung: 97.4359% (minimum 99%, Missing); lymph node: 74.5098% (minimum 97%, Missing); midbrain: 90.4762% (minimum 99%, Missing); skin: 80.8511% (minimum 95%, Missing); small intestine: 97.4359% (minimum 99%, Missing); spinal cord: 95.0000% (minimum 99%, Missing); spleen: 63.3333% (minimum 95%, Missing)",0,80,unavailable,0.4,1.3,2.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus; tonsil,ENSG00000268916,CSAG3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.316667,-0.224902,-0.0852381
False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,False,,0,3,partial,0.8,0,0,,skin 2 / epidermal cells: Low (Supported),53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 2 / epidermal cells,ENSG00000268940,CT45A1,reproductive_required,False,True,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"amygdala: 95.0820% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.5484% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 96.6667% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 93.5484% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 95.0820% (minimum 99%, Baseline (adaptation disabled)); lung: 96.6667% (minimum 99%, Baseline (adaptation disabled)); midbrain: 95.8678% (minimum 99%, Baseline (adaptation disabled)); retina: 95.0820% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 93.5484% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.8,0,0,,skin 2 / epidermal cells: Low (Supported),53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 2 / epidermal cells,ENSG00000268940,CT45A1,current_fixed,False,True,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.0545161
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"amygdala: 95.0820% (minimum 99%, Missing); basal ganglia: 93.5484% (minimum 99%, Missing); cerebral cortex: 96.6667% (minimum 97%, Supported); hippocampal formation: 93.5484% (minimum 99%, Missing); hypothalamus: 95.0820% (minimum 99%, Missing); lung: 96.6667% (minimum 97%, Supported); midbrain: 95.8678% (minimum 99%, Missing); retina: 95.0820% (minimum 99%, Missing); spinal cord: 93.5484% (minimum 99%, Missing)",0,3,partial,0.8,0,0,,skin 2 / epidermal cells: Low (Supported),53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 2 / epidermal cells,ENSG00000268940,CT45A1,current_adaptive,False,True,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.0545161
True,compatible,,True,True,False,,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000268964,ERVV-2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.5904% (minimum 99%, Baseline (adaptation disabled)); kidney: 95.2941% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 94.1860% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000268964,ERVV-2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0378049,0.03,-0.0481395
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 97.5904% (minimum 99%, Missing); kidney: 95.2941% (minimum 99%, Missing); skeletal muscle: 94.1860% (minimum 99%, Missing)",0,80,unavailable,0.5,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000268964,ERVV-2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0378049,0.03,-0.0481395
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000268988,SPANXN2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000268988,SPANXN2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000268988,SPANXN2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1.2,0.2,1.2,"retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,ENSG00000268994,FAM236B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 98.7590% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.2,0.2,1.2,"retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,ENSG00000268994,FAM236B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0375905,0.0279101,-0.00240951
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 98.7590% (minimum 99%, Missing)",0,80,unavailable,1.2,0.2,1.2,"retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,ENSG00000268994,FAM236B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0375905,0.0279101,-0.00240951
True,compatible,,True,True,False,,0,2,partial,0.1,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000269058,CALR3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,2,partial,0.1,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000269058,CALR3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0484152,0.03,0.00841521
True,compatible,,True,True,True,,0,2,partial,0.1,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000269058,CALR3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0484152,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,False,,0,4,partial,2.3,0,0,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),52,not_established,not_triggered,,,ENSG00000269096,CT45A3,reproductive_required,False,True,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"amygdala: 81.4159% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 83.6364% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9247% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 90.1961% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.8723% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 80.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 85.1852% (minimum 99%, Baseline (adaptation disabled)); lung: 95.8333% (minimum 99%, Baseline (adaptation disabled)); midbrain: 87.6190% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 96.8421% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.4037% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,2.3,0,0,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),52,not_established,not_triggered,,,ENSG00000269096,CT45A3,current_fixed,False,True,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.19
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"amygdala: 81.4159% (minimum 99%, Missing); basal ganglia: 83.6364% (minimum 99%, Missing); cerebral cortex: 90.1961% (minimum 97%, Supported); choroid plexus: 97.8723% (minimum 99%, Missing); hippocampal formation: 80.0000% (minimum 99%, Missing); hypothalamus: 85.1852% (minimum 99%, Missing); lung: 95.8333% (minimum 97%, Supported); midbrain: 87.6190% (minimum 99%, Missing); pituitary gland: 96.8421% (minimum 99%, Missing); spinal cord: 84.4037% (minimum 99%, Missing)",0,4,partial,2.3,0,0,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),52,not_established,not_triggered,,,ENSG00000269096,CT45A3,current_adaptive,False,True,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Gong 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.19
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.2,0.1,0,"pituitary gland: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000269405,NXF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734,Jamin 2021;Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 97.3684% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.6667% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.7320% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1039% (minimum 99%, Baseline (adaptation disabled)); lung: 98.6667% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 82.2222% (minimum 99%, Baseline (adaptation disabled)); retina: 96.7320% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,3.2,0.1,0,"pituitary gland: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000269405,NXF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734,Jamin 2021;Loriot 2025,0.05,0.0232886,-0.167778
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.6667% (minimum 99%, Missing); basal ganglia: 97.3684% (minimum 99%, Missing); cerebellum: 98.6667% (minimum 99%, Missing); choroid plexus: 96.7320% (minimum 99%, Missing); hypothalamus: 96.1039% (minimum 99%, Missing); lung: 98.6667% (minimum 99%, Missing); pituitary gland: 82.2222% (minimum 99%, Missing); retina: 96.7320% (minimum 99%, Missing)",0,80,unavailable,3.2,0.1,0,"pituitary gland: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000269405,NXF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734,Jamin 2021;Loriot 2025,0.05,0.0232886,-0.167778
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.4,0.1,0,"pituitary gland: 2.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000269437,NXF2B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.0132% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.0132% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.0132% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.6667% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 96.1039% (minimum 99%, Baseline (adaptation disabled)); lung: 98.6667% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 86.0465% (minimum 99%, Baseline (adaptation disabled)); retina: 98.0132% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.4,0.1,0,"pituitary gland: 2.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000269437,NXF2B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,0.0232886,-0.129535
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 98.6667% (minimum 99%, Missing); basal ganglia: 98.0132% (minimum 99%, Missing); cerebellum: 98.0132% (minimum 99%, Missing); choroid plexus: 98.0132% (minimum 99%, Missing); hippocampal formation: 98.6667% (minimum 99%, Missing); hypothalamus: 96.1039% (minimum 99%, Missing); lung: 98.6667% (minimum 99%, Missing); pituitary gland: 86.0465% (minimum 99%, Missing); retina: 98.0132% (minimum 99%, Missing)",0,80,unavailable,2.4,0.1,0,"pituitary gland: 2.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000269437,NXF2B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,0.05,0.0232886,-0.129535
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.2,0.7,2.1,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000269502,DMRTC1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.5294% (minimum 99%, Baseline (adaptation disabled)); amygdala: 78.1250% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 58.1395% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 73.5294% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 43.8596% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 83.3333% (minimum 99%, Baseline (adaptation disabled)); colon: 92.5926% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.5926% (minimum 99%, Baseline (adaptation disabled)); esophagus: 96.1538% (minimum 97%, Baseline (adaptation disabled)); hippocampal formation: 83.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 69.4444% (minimum 99%, Baseline (adaptation disabled)); kidney: 89.2857% (minimum 99%, Baseline (adaptation disabled)); lung: 92.5926% (minimum 99%, Baseline (adaptation disabled)); lymph node: 78.1250% (minimum 97%, Baseline (adaptation disabled)); midbrain: 89.2857% (minimum 99%, Baseline (adaptation disabled)); pancreas: 78.1250% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 80.6452% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 59.5238% (minimum 99%, Baseline (adaptation disabled)); rectum: 89.2857% (minimum 97%, Baseline (adaptation disabled)); retina: 52.0833% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 86.2069% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 96.1538% (minimum 99%, Baseline (adaptation disabled)); small intestine: 86.2069% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 86.2069% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.5926% (minimum 99%, Baseline (adaptation disabled)); spleen: 80.6452% (minimum 95%, Baseline (adaptation disabled)); stomach: 86.2069% (minimum 97%, Baseline (adaptation disabled)); thymus: 78.1250% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 54.3478% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 92.5926% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,3.2,0.7,2.1,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000269502,DMRTC1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.406522,-0.18875,-0.551404
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.5294% (minimum 99%, Missing); amygdala: 78.1250% (minimum 99%, Missing); basal ganglia: 58.1395% (minimum 99%, Missing); cerebellum: 73.5294% (minimum 99%, Missing); cerebral cortex: 43.8596% (minimum 99%, Missing); choroid plexus: 83.3333% (minimum 99%, Missing); colon: 92.5926% (minimum 97%, Missing); duodenum: 92.5926% (minimum 99%, Missing); esophagus: 96.1538% (minimum 97%, Missing); hippocampal formation: 83.3333% (minimum 99%, Missing); hypothalamus: 69.4444% (minimum 99%, Missing); kidney: 89.2857% (minimum 99%, Missing); lung: 92.5926% (minimum 99%, Missing); lymph node: 78.1250% (minimum 97%, Missing); midbrain: 89.2857% (minimum 99%, Missing); pancreas: 78.1250% (minimum 99%, Missing); parathyroid gland: 80.6452% (minimum 97%, Missing); pituitary gland: 59.5238% (minimum 99%, Missing); rectum: 89.2857% (minimum 97%, Missing); retina: 52.0833% (minimum 99%, Missing); salivary gland: 86.2069% (minimum 97%, Missing); skeletal muscle: 96.1538% (minimum 99%, Missing); small intestine: 86.2069% (minimum 99%, Missing); smooth muscle: 86.2069% (minimum 99%, Missing); spinal cord: 92.5926% (minimum 99%, Missing); spleen: 80.6452% (minimum 95%, Missing); stomach: 86.2069% (minimum 97%, Missing); thymus: 78.1250% (minimum 95%, Missing); thyroid gland: 54.3478% (minimum 95%, Missing); urinary bladder: 92.5926% (minimum 97%, Missing)",0,80,unavailable,3.2,0.7,2.1,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,ENSG00000269502,DMRTC1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.406522,-0.18875,-0.551404
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.7,0.2,0.1,"kidney: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000269526,ERVV-1,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 93.9394% (minimum 99%, Baseline (adaptation disabled)); kidney: 90.1163% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.7,0.2,0.1,"kidney: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000269526,ERVV-1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0435897,0.0172611,-0.0888372
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 93.9394% (minimum 99%, Missing); kidney: 90.1163% (minimum 99%, Missing)",0,80,unavailable,1.7,0.2,0.1,"kidney: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000269526,ERVV-1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y,Gong 2021,0.0435897,0.0172611,-0.0888372
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,1.4,0,0,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,ENSG00000269586,CT45A10,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 88.2353% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 93.7500% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.9011% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 94.7368% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 86.5385% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 93.7500% (minimum 99%, Baseline (adaptation disabled)); lung: 98.9011% (minimum 99%, Baseline (adaptation disabled)); midbrain: 92.7835% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 89.1089% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,1.4,0,0,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,ENSG00000269586,CT45A10,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,-0.124615
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 88.2353% (minimum 99%, Missing); basal ganglia: 93.7500% (minimum 99%, Missing); cerebral cortex: 94.7368% (minimum 97%, Supported); hippocampal formation: 86.5385% (minimum 99%, Missing); hypothalamus: 93.7500% (minimum 99%, Missing); midbrain: 92.7835% (minimum 99%, Missing); spinal cord: 89.1089% (minimum 99%, Missing)",0,3,partial,1.4,0,0,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,ENSG00000269586,CT45A10,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,-0.124615
True,compatible,,True,True,False,,0,2,partial,0.1,0,0,,,52,not_established,not_triggered,,,ENSG00000269791,SSX4B,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 96.2963% (minimum 99%, Baseline (adaptation disabled))",0,2,partial,0.1,0,0,,,52,not_established,not_triggered,,,ENSG00000269791,SSX4B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.03,-0.027037
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 96.2963% (minimum 97%, Supported)",0,2,partial,0.1,0,0,,,52,not_established,not_triggered,,,ENSG00000269791,SSX4B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.03,-0.00703704
True,compatible,,True,True,False,,0,80,unavailable,0.2,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000270379,HEATR9,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.9899% (minimum 99%, Baseline (adaptation disabled)); lung: 98.9899% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000270379,HEATR9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0107843,0.019899,-0.01
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"duodenum: 98.9899% (minimum 99%, Missing); lung: 98.9899% (minimum 99%, Missing); small intestine: 98.0000% (minimum 99%, Missing)",0,80,unavailable,0.2,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,ENSG00000270379,HEATR9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0107843,0.019899,-0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000270601,PRAMEF5,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000270601,PRAMEF5,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000270601,PRAMEF5,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.1,0.1,0.3,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,ENSG00000270806,C17orf50,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.9403% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,0.1,0.3,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,ENSG00000270806,C17orf50,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,0.0470874,0.0290272,-0.000597303
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 98.9403% (minimum 99%, Missing)",0,80,unavailable,1.1,0.1,0.3,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,ENSG00000270806,C17orf50,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021;Loriot 2025;da Silva 2017,0.0470874,0.0290272,-0.000597303
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,False,,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,ENSG00000270946,CT45A9,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"basal ganglia: 88.8889% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 88.8889% (minimum 99%, Baseline (adaptation disabled))",0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,ENSG00000270946,CT45A9,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,-0.101111
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"basal ganglia: 88.8889% (minimum 99%, Missing); hypothalamus: 88.8889% (minimum 99%, Missing)",0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,ENSG00000270946,CT45A9,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,-0.101111
True,compatible,,True,True,False,,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000271321,CTAGE6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000271321,CTAGE6,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0429078,0.0159155,0.0029078
True,compatible,,True,True,True,,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000271321,CTAGE6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0429078,0.0159155,0.0029078
True,compatible,,True,True,False,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000271449,CT45A2,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000271449,CT45A2,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,ENSG00000271449,CT45A2,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0.1,0,13.8,"skin: 13.8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000272804,KRTAP10-7,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0.1,0,13.8,"skin: 13.8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000272804,KRTAP10-7,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0.1,0,13.8,"skin: 13.8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000272804,KRTAP10-7,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1,0.8,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000272968,RBAK-RBAKDN,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 98.7762% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.7762% (minimum 99%, Baseline (adaptation disabled)); retina: 98.2609% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.9492% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1,0.8,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000272968,RBAK-RBAKDN,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0360384,0.0160384,-0.0073913
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 98.7762% (minimum 99%, Missing); cerebral cortex: 98.7762% (minimum 99%, Missing); retina: 98.2609% (minimum 99%, Missing); small intestine: 98.9492% (minimum 99%, Missing)",0,80,unavailable,1,0.8,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000272968,RBAK-RBAKDN,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0360384,0.0160384,-0.0073913
True,compatible,,True,True,False,,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,ENSG00000273111,LYPD4,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,ENSG00000273111,LYPD4,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.0290196,0.00706458
True,compatible,,True,True,True,,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,ENSG00000273111,LYPD4,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.0290196,0.00706458
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,False,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000273313,RBAKDN,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000273313,RBAKDN,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000273313,RBAKDN,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,,True,True,False,,0,3,partial,0.1,0,0.1,,,53,not_established,not_triggered,,,ENSG00000273696,CT45A7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 80.0000% (minimum 95%, Baseline (adaptation disabled)); lung: 80.0000% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,0.1,0,0.1,,,53,not_established,not_triggered,,,ENSG00000273696,CT45A7,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,-0.15,0.03,-0.19
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lung: 80.0000% (minimum 97%, Supported)",0,3,partial,0.1,0,0.1,,,53,not_established,not_triggered,,,ENSG00000273696,CT45A7,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0,0.03,-0.17
True,compatible,,True,True,False,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000273976,GOLGA6L1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.2206% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000273976,GOLGA6L1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.00779359
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebral cortex: 98.2206% (minimum 99%, Missing)",0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,ENSG00000273976,GOLGA6L1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.00779359
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000274102,OR4M2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000274102,OR4M2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000274102,OR4M2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.6,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000274183,H2AB1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 95.0000% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.2759% (minimum 99%, Baseline (adaptation disabled)); duodenum: 96.6102% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.2759% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.2759% (minimum 99%, Baseline (adaptation disabled)); liver: 98.2759% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.2759% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.6102% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.2759% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000274183,H2AB1,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0161017,0.0127586,-0.04
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 95.0000% (minimum 99%, Missing); cerebellum: 98.2759% (minimum 99%, Missing); duodenum: 96.6102% (minimum 99%, Missing); heart muscle: 98.2759% (minimum 99%, Missing); kidney: 98.2759% (minimum 99%, Missing); liver: 98.2759% (minimum 99%, Missing); pancreas: 98.2759% (minimum 99%, Missing); skeletal muscle: 96.6102% (minimum 99%, Missing); small intestine: 98.2759% (minimum 99%, Missing)",0,80,unavailable,0.6,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,ENSG00000274183,H2AB1,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.0161017,0.0127586,-0.04
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000274209,ANTXRL,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 92.5373% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000274209,ANTXRL,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.042,0.022,-0.0646269
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 92.5373% (minimum 99%, Missing)",0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,ENSG00000274209,ANTXRL,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.042,0.022,-0.0646269
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,1.4,0,0,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000274274,GAGE13,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.4545% (minimum 99%, Baseline (adaptation disabled))",0,4,partial,1.4,0,0,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000274274,GAGE13,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,-0.0154545
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 97.4545% (minimum 99%, Missing)",0,4,partial,1.4,0,0,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,ENSG00000274274,GAGE13,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Seager 2024;Loriot 2025;da Silva 2017,0.05,0.03,-0.0154545
True,compatible,,True,True,False,,0,1,partial,0,0.1,0.3,,,55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000274391,TPTE,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Bruggeman 2018;Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0,0.1,0.3,,,55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000274391,TPTE,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Bruggeman 2018;Gong 2021;da Silva 2017,0.0472727,0.0290893,0.01
True,compatible,,True,True,True,,0,1,partial,0,0.1,0.3,,,55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,ENSG00000274391,TPTE,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Jamin 2021;Bruggeman 2018;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,False,,0,2,partial,7,4,4.1,"cerebellum: 7 nTPM (vital, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); basal ganglia: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); colon: 2.3 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000274419,TBC1D3D,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 80.6818% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 69.6078% (minimum 99%, Baseline (adaptation disabled)); amygdala: 79.7753% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 73.9583% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 50.3546% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 73.9583% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 51.0791% (minimum 99%, Baseline (adaptation disabled)); colon: 75.5319% (minimum 97%, Baseline (adaptation disabled)); duodenum: 86.5854% (minimum 99%, Baseline (adaptation disabled)); esophagus: 63.9640% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 82.5581% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 79.7753% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 77.1739% (minimum 99%, Baseline (adaptation disabled)); kidney: 74.7368% (minimum 99%, Baseline (adaptation disabled)); liver: 68.2692% (minimum 99%, Baseline (adaptation disabled)); lung: 76.3441% (minimum 99%, Baseline (adaptation disabled)); lymph node: 94.6667% (minimum 97%, Baseline (adaptation disabled)); midbrain: 81.6092% (minimum 99%, Baseline (adaptation disabled)); pancreas: 73.1959% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 95.9459% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.6078% (minimum 99%, Baseline (adaptation disabled)); rectum: 92.2078% (minimum 97%, Baseline (adaptation disabled)); retina: 76.3441% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 69.6078% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 78.8889% (minimum 99%, Baseline (adaptation disabled)); skin: 65.1376% (minimum 95%, Baseline (adaptation disabled)); small intestine: 63.3929% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.6111% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 84.5238% (minimum 99%, Baseline (adaptation disabled)); spleen: 63.3929% (minimum 95%, Baseline (adaptation disabled)); stomach: 75.5319% (minimum 97%, Baseline (adaptation disabled)); thyroid gland: 77.1739% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 67.6190% (minimum 97%, Baseline (adaptation disabled))",0,2,partial,7,4,4.1,"cerebellum: 7 nTPM (vital, limit 1); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); stomach: 2.3 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000274419,TBC1D3D,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.316071,-0.33036,-0.486454
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 80.6818% (minimum 90%, Approved); adrenal gland: 69.6078% (minimum 98%, Approved); amygdala: 79.7753% (minimum 99%, Missing); basal ganglia: 73.9583% (minimum 99%, Missing); cerebellum: 50.3546% (minimum 98%, Approved); cerebral cortex: 73.9583% (minimum 98%, Approved); choroid plexus: 51.0791% (minimum 99%, Missing); colon: 75.5319% (minimum 97%, Missing); duodenum: 86.5854% (minimum 98%, Approved); esophagus: 63.9640% (minimum 95%, Approved); heart muscle: 82.5581% (minimum 98%, Approved); hippocampal formation: 79.7753% (minimum 99%, Missing); hypothalamus: 77.1739% (minimum 99%, Missing); kidney: 74.7368% (minimum 98%, Approved); liver: 68.2692% (minimum 98%, Approved); lung: 76.3441% (minimum 98%, Approved); lymph node: 94.6667% (minimum 95%, Approved); midbrain: 81.6092% (minimum 99%, Missing); pancreas: 73.1959% (minimum 99%, Missing); pituitary gland: 69.6078% (minimum 99%, Missing); rectum: 92.2078% (minimum 95%, Approved); retina: 76.3441% (minimum 99%, Missing); salivary gland: 69.6078% (minimum 95%, Approved); skeletal muscle: 78.8889% (minimum 98%, Approved); skin: 65.1376% (minimum 90%, Approved); small intestine: 63.3929% (minimum 98%, Approved); spinal cord: 84.5238% (minimum 99%, Missing); spleen: 63.3929% (minimum 90%, Approved); stomach: 75.5319% (minimum 95%, Approved); thyroid gland: 77.1739% (minimum 90%, Approved); urinary bladder: 67.6190% (minimum 97%, Missing)",0,2,partial,7,4,4.1,"cerebellum: 7 nTPM (vital, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 2); urinary bladder: 3.4 nTPM (protected, limit 2); liver: 3.3 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); basal ganglia: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); colon: 2.3 nTPM (protected, limit 2); lung: 2.2 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; tonsil,ENSG00000274419,TBC1D3D,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,-0.266071,-0.31036,-0.479209
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,7,partial,0.2,0.3,0.5,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000274600,RIMBP3B,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"pancreas: 98.5075% (minimum 99%, Baseline (adaptation disabled))",0,7,partial,0.2,0.3,0.5,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000274600,RIMBP3B,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0135036,0.00777778,-0.00492537
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,7,partial,0.2,0.3,0.5,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000274600,RIMBP3B,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0135036,0.03,0.0024812
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,False,,0,4,partial,0.8,0.2,0.7,,adipose tissue / adipocytes: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000274618,H4C6,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 20.0000% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 40.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 66.6667% (minimum 97%, Baseline (adaptation disabled)); esophagus: 66.6667% (minimum 97%, Baseline (adaptation disabled)); lymph node: 50.0000% (minimum 97%, Baseline (adaptation disabled)); thymus: 22.2222% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,0.8,0.2,0.7,,adipose tissue / adipocytes: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000274618,H4C6,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.727778,-0.47,-0.79
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 20.0000% (minimum 99%, Missing); choroid plexus: 40.0000% (minimum 99%, Missing); colon: 66.6667% (minimum 97%, Missing); esophagus: 66.6667% (minimum 97%, Missing); lymph node: 50.0000% (minimum 97%, Missing); thymus: 22.2222% (minimum 95%, Missing)",0,4,partial,0.8,0.2,0.7,,adipose tissue / adipocytes: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000274618,H4C6,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.727778,-0.47,-0.79
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000274764,PRAMEF27,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000274764,PRAMEF27,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000274764,PRAMEF27,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,4,partial,0.9,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000274933,TBC1D3I,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 98.5507% (minimum 99%, Baseline (adaptation disabled)); amygdala: 98.5507% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5507% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 88.3117% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 93.1507% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.5507% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 97.1429% (minimum 99%, Baseline (adaptation disabled)); duodenum: 97.1429% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5507% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5507% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5507% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.1429% (minimum 99%, Baseline (adaptation disabled)); liver: 95.7746% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5507% (minimum 99%, Baseline (adaptation disabled)); lymph node: 95.7746% (minimum 97%, Baseline (adaptation disabled)); midbrain: 98.5507% (minimum 99%, Baseline (adaptation disabled)); pancreas: 97.1429% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1429% (minimum 99%, Baseline (adaptation disabled)); retina: 93.1507% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 94.4444% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 88.3117% (minimum 99%, Baseline (adaptation disabled)); skin: 91.8919% (minimum 95%, Baseline (adaptation disabled)); small intestine: 95.7746% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 98.5507% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 98.5507% (minimum 99%, Baseline (adaptation disabled)); urinary bladder: 95.7746% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,0.9,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000274933,TBC1D3I,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,-0.0310811,-0.0255556,-0.106883
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 98.5507% (minimum 99%, Missing); basal ganglia: 98.5507% (minimum 99%, Missing); bone marrow: 88.3117% (minimum 98%, Approved); cerebellum: 93.1507% (minimum 98%, Approved); choroid plexus: 97.1429% (minimum 99%, Missing); duodenum: 97.1429% (minimum 98%, Approved); hippocampal formation: 98.5507% (minimum 99%, Missing); hypothalamus: 98.5507% (minimum 99%, Missing); kidney: 97.1429% (minimum 98%, Approved); liver: 95.7746% (minimum 98%, Approved); midbrain: 98.5507% (minimum 99%, Missing); pancreas: 97.1429% (minimum 98%, Approved); pituitary gland: 97.1429% (minimum 99%, Missing); retina: 93.1507% (minimum 99%, Missing); salivary gland: 94.4444% (minimum 95%, Approved); skeletal muscle: 88.3117% (minimum 98%, Approved); small intestine: 95.7746% (minimum 98%, Approved); spinal cord: 98.5507% (minimum 99%, Missing)",0,4,partial,0.9,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000274933,TBC1D3I,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0189189,-0.00555556,-0.0968831
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,3.2,1.1,1.9,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000275004,ZNF280B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 89.0411% (minimum 99%, Baseline (adaptation disabled)); amygdala: 88.4354% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 87.8378% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.7444% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 84.4156% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 83.3333% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 96.2963% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 96.2963% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 89.6552% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 81.2500% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.4848% (minimum 99%, Baseline (adaptation disabled)); lung: 98.4848% (minimum 99%, Baseline (adaptation disabled)); lymph node: 92.8571% (minimum 97%, Baseline (adaptation disabled)); midbrain: 90.2778% (minimum 99%, Baseline (adaptation disabled)); pancreas: 96.2963% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 92.1986% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 90.9091% (minimum 99%, Baseline (adaptation disabled)); retina: 80.2469% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.7444% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.0149% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 94.2029% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 90.2778% (minimum 99%, Baseline (adaptation disabled)); spleen: 93.5252% (minimum 95%, Baseline (adaptation disabled)); thymus: 94.2029% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 87.2483% (minimum 95%, Baseline (adaptation disabled))",0,80,unavailable,3.2,1.1,1.9,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000275004,ZNF280B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.0775168,-0.0480142,-0.187531
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 89.0411% (minimum 99%, Missing); amygdala: 88.4354% (minimum 99%, Missing); basal ganglia: 87.8378% (minimum 99%, Missing); bone marrow: 97.7444% (minimum 99%, Missing); cerebellum: 84.4156% (minimum 99%, Missing); cerebral cortex: 83.3333% (minimum 99%, Missing); choroid plexus: 96.2963% (minimum 99%, Missing); heart muscle: 96.2963% (minimum 99%, Missing); hippocampal formation: 89.6552% (minimum 99%, Missing); hypothalamus: 81.2500% (minimum 99%, Missing); kidney: 98.4848% (minimum 99%, Missing); lung: 98.4848% (minimum 99%, Missing); lymph node: 92.8571% (minimum 97%, Missing); midbrain: 90.2778% (minimum 99%, Missing); pancreas: 96.2963% (minimum 99%, Missing); parathyroid gland: 92.1986% (minimum 97%, Missing); pituitary gland: 90.9091% (minimum 99%, Missing); retina: 80.2469% (minimum 99%, Missing); skeletal muscle: 97.7444% (minimum 99%, Missing); small intestine: 97.0149% (minimum 99%, Missing); smooth muscle: 94.2029% (minimum 99%, Missing); spinal cord: 90.2778% (minimum 99%, Missing); spleen: 93.5252% (minimum 95%, Missing); thymus: 94.2029% (minimum 95%, Missing); thyroid gland: 87.2483% (minimum 95%, Missing)",0,80,unavailable,3.2,1.1,1.9,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000275004,ZNF280B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Jamin 2021;Bruggeman 2018,-0.0775168,-0.0480142,-0.187531
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,2.9,3.7,3.1,"parathyroid gland: 3.7 nTPM (protected, limit 2); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000275111,ZNF2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.8525% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.6866% (minimum 99%, Baseline (adaptation disabled)); amygdala: 72.4138% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 70.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 85.7143% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 65.6250% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.6364% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 75.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 64.6154% (minimum 97%, Baseline (adaptation disabled)); duodenum: 67.7419% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.6250% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 59.1549% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.1864% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 72.4138% (minimum 99%, Baseline (adaptation disabled)); kidney: 62.6866% (minimum 99%, Baseline (adaptation disabled)); liver: 70.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 64.6154% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.1549% (minimum 97%, Baseline (adaptation disabled)); midbrain: 72.4138% (minimum 99%, Baseline (adaptation disabled)); pancreas: 66.6667% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 53.1646% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 70.0000% (minimum 99%, Baseline (adaptation disabled)); rectum: 71.1864% (minimum 97%, Baseline (adaptation disabled)); retina: 60.8696% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 66.6667% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 59.1549% (minimum 99%, Baseline (adaptation disabled)); skin: 60.0000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 71.1864% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.6866% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.8696% (minimum 95%, Baseline (adaptation disabled)); stomach: 64.6154% (minimum 97%, Baseline (adaptation disabled)); thymus: 57.5342% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 58.3333% (minimum 95%, Baseline (adaptation disabled)); tongue: 54.5455% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 65.6250% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,2.9,3.7,3.1,"parathyroid gland: 3.7 nTPM (protected, limit 2); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000275111,ZNF2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.374658,-0.438354,-0.398451
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 68.8525% (minimum 95%, Missing); adrenal gland: 62.6866% (minimum 99%, Missing); amygdala: 72.4138% (minimum 99%, Missing); basal ganglia: 70.0000% (minimum 99%, Missing); bone marrow: 85.7143% (minimum 99%, Missing); cerebellum: 65.6250% (minimum 99%, Missing); cerebral cortex: 63.6364% (minimum 99%, Missing); choroid plexus: 75.0000% (minimum 99%, Missing); colon: 64.6154% (minimum 97%, Missing); duodenum: 67.7419% (minimum 99%, Missing); esophagus: 65.6250% (minimum 97%, Missing); heart muscle: 59.1549% (minimum 99%, Missing); hippocampal formation: 71.1864% (minimum 99%, Missing); hypothalamus: 72.4138% (minimum 99%, Missing); kidney: 62.6866% (minimum 99%, Missing); liver: 70.0000% (minimum 99%, Missing); lung: 64.6154% (minimum 99%, Missing); lymph node: 59.1549% (minimum 97%, Missing); midbrain: 72.4138% (minimum 99%, Missing); pancreas: 66.6667% (minimum 99%, Missing); parathyroid gland: 53.1646% (minimum 97%, Missing); pituitary gland: 70.0000% (minimum 99%, Missing); rectum: 71.1864% (minimum 97%, Missing); retina: 60.8696% (minimum 99%, Missing); salivary gland: 66.6667% (minimum 97%, Missing); skeletal muscle: 59.1549% (minimum 99%, Missing); skin: 60.0000% (minimum 95%, Missing); small intestine: 71.1864% (minimum 99%, Missing); smooth muscle: 62.6866% (minimum 99%, Missing); spinal cord: 70.0000% (minimum 99%, Missing); spleen: 60.8696% (minimum 95%, Missing); stomach: 64.6154% (minimum 97%, Missing); thymus: 57.5342% (minimum 95%, Missing); thyroid gland: 58.3333% (minimum 95%, Missing); tongue: 54.5455% (minimum 97%, Missing); urinary bladder: 65.6250% (minimum 97%, Missing)",0,80,unavailable,2.9,3.7,3.1,"parathyroid gland: 3.7 nTPM (protected, limit 2); tongue: 3.5 nTPM (protected, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lymph node: 2.9 nTPM (protected, limit 2); retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); stomach: 2.3 nTPM (protected, limit 2); lung: 2.3 nTPM (vital, limit 1); colon: 2.3 nTPM (protected, limit 2); urinary bladder: 2.2 nTPM (protected, limit 2); esophagus: 2.2 nTPM (protected, limit 2); cerebellum: 2.2 nTPM (vital, limit 1); salivary gland: 2.1 nTPM (protected, limit 2); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000275111,ZNF2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.374658,-0.438354,-0.398451
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,4,partial,2.4,14.9,0.2,"stomach: 14.9 nTPM (protected, limit 4); retina: 2.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000275113,GAGE2E,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 91.3669% (minimum 99%, Baseline (adaptation disabled)); stomach: 63.0273% (minimum 97%, Baseline (adaptation disabled))",0,4,partial,2.4,14.9,0.2,"stomach: 14.9 nTPM (protected, limit 2); retina: 2.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000275113,GAGE2E,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.0421875,-0.339727,-0.0763309
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 91.3669% (minimum 99%, Missing); stomach: 63.0273% (minimum 95%, Approved)",0,4,partial,2.4,14.9,0.2,"stomach: 14.9 nTPM (protected, limit 4); retina: 2.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000275113,GAGE2E,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,-0.319727,-0.0763309
True,compatible,,True,True,False,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000275489,SPMAP1,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000275489,SPMAP1,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0395288,0.03,0.00473684
True,compatible,,True,True,True,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000275489,SPMAP1,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0395288,0.03,0.00473684
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1.5,1.9,0.8,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000275520,FAM236A,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,1.5,1.9,0.8,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000275520,FAM236A,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0447264,0.0175654,0.00015748
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,1.5,1.9,0.8,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,ENSG00000275520,FAM236A,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0447264,0.0175654,0.00015748
True,compatible,,True,True,False,,0,1,partial,0.3,0.2,1.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000275722,LYZL6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,1,partial,0.3,0.2,1.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000275722,LYZL6,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0269392,0.0257265,0.00360341
True,compatible,,True,True,True,,0,1,partial,0.3,0.2,1.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,ENSG00000275722,LYZL6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.00360341
False,excluded,insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000275774,HNRNPCL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000275774,HNRNPCL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000275774,HNRNPCL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,False,,0,7,partial,0.3,0.7,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000275793,RIMBP3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.9247% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.9247% (minimum 99%, Baseline (adaptation disabled))",0,7,partial,0.3,0.7,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000275793,RIMBP3,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,0.015035,0.00526502,-0.000752688
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 98.9247% (minimum 99%, Missing); hypothalamus: 98.9247% (minimum 99%, Missing)",0,7,partial,0.3,0.7,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000275793,RIMBP3,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021;Carter 2023;da Silva 2017,0.015035,0.0263899,-0.000752688
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.6,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000275954,TBC1D3F,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 97.0588% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 98.5075% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 97.0588% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 91.6667% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.5075% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.5075% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.5075% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.5075% (minimum 99%, Baseline (adaptation disabled)); kidney: 97.0588% (minimum 99%, Baseline (adaptation disabled)); liver: 97.0588% (minimum 99%, Baseline (adaptation disabled)); lung: 98.5075% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.5075% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.0588% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 97.0588% (minimum 99%, Baseline (adaptation disabled)); small intestine: 97.0588% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.6,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000275954,TBC1D3F,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.00652174,0.000588235,-0.0733333
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 97.0588% (minimum 99%, Missing); basal ganglia: 98.5075% (minimum 99%, Missing); bone marrow: 97.0588% (minimum 99%, Missing); cerebellum: 91.6667% (minimum 99%, Missing); cerebral cortex: 98.5075% (minimum 99%, Missing); heart muscle: 98.5075% (minimum 99%, Missing); hippocampal formation: 98.5075% (minimum 99%, Missing); hypothalamus: 98.5075% (minimum 99%, Missing); kidney: 97.0588% (minimum 99%, Missing); liver: 97.0588% (minimum 99%, Missing); lung: 98.5075% (minimum 99%, Missing); pancreas: 98.5075% (minimum 99%, Missing); pituitary gland: 97.0588% (minimum 99%, Missing); skeletal muscle: 97.0588% (minimum 99%, Missing); small intestine: 97.0588% (minimum 99%, Missing)",0,80,unavailable,0.6,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000275954,TBC1D3F,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.00652174,0.000588235,-0.0733333
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000275969,SPATA31A3,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000275969,SPATA31A3,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000275969,SPATA31A3,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276040,SPATA31A7,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276040,SPATA31A7,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276040,SPATA31A7,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,10.2,4.8,5.3,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); thyroid gland: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); pancreas: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); esophagus: 3.7 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000276234,TADA2A,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.5926% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 74.2424% (minimum 99%, Baseline (adaptation disabled)); amygdala: 62.8205% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 61.2500% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 79.6748% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 49.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 56.3218% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.6748% (minimum 99%, Baseline (adaptation disabled)); colon: 67.1233% (minimum 97%, Baseline (adaptation disabled)); duodenum: 85.2174% (minimum 99%, Baseline (adaptation disabled)); esophagus: 72.5926% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 70.5036% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 64.0523% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 61.2500% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.0588% (minimum 99%, Baseline (adaptation disabled)); liver: 68.0556% (minimum 99%, Baseline (adaptation disabled)); lung: 75.3846% (minimum 99%, Baseline (adaptation disabled)); lymph node: 83.7607% (minimum 97%, Baseline (adaptation disabled)); midbrain: 61.2500% (minimum 99%, Baseline (adaptation disabled)); pancreas: 67.1233% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 89.9083% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 68.5315% (minimum 99%, Baseline (adaptation disabled)); rectum: 78.4000% (minimum 97%, Baseline (adaptation disabled)); retina: 67.1233% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 72.0588% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 62.0253% (minimum 99%, Baseline (adaptation disabled)); skin: 68.0556% (minimum 95%, Baseline (adaptation disabled)); small intestine: 65.3333% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 87.5000% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 61.6352% (minimum 99%, Baseline (adaptation disabled)); spleen: 64.9007% (minimum 95%, Baseline (adaptation disabled)); stomach: 70.5036% (minimum 97%, Baseline (adaptation disabled)); thymus: 85.9649% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 64.9007% (minimum 95%, Baseline (adaptation disabled)); tongue: 88.2883% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 67.1233% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,10.2,4.8,5.3,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); thyroid gland: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); pancreas: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); esophagus: 3.7 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000276234,TADA2A,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.300993,-0.298767,-0.5
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 72.5926% (minimum 95%, Missing); adrenal gland: 74.2424% (minimum 99%, Missing); amygdala: 62.8205% (minimum 99%, Missing); basal ganglia: 61.2500% (minimum 99%, Missing); bone marrow: 79.6748% (minimum 99%, Missing); cerebellum: 49.0000% (minimum 99%, Missing); cerebral cortex: 56.3218% (minimum 99%, Missing); choroid plexus: 79.6748% (minimum 99%, Missing); colon: 67.1233% (minimum 97%, Missing); duodenum: 85.2174% (minimum 99%, Missing); esophagus: 72.5926% (minimum 97%, Missing); heart muscle: 70.5036% (minimum 99%, Missing); hippocampal formation: 64.0523% (minimum 99%, Missing); hypothalamus: 61.2500% (minimum 99%, Missing); kidney: 72.0588% (minimum 99%, Missing); liver: 68.0556% (minimum 99%, Missing); lung: 75.3846% (minimum 99%, Missing); lymph node: 83.7607% (minimum 97%, Missing); midbrain: 61.2500% (minimum 99%, Missing); pancreas: 67.1233% (minimum 99%, Missing); parathyroid gland: 89.9083% (minimum 97%, Missing); pituitary gland: 68.5315% (minimum 99%, Missing); rectum: 78.4000% (minimum 97%, Missing); retina: 67.1233% (minimum 99%, Missing); salivary gland: 72.0588% (minimum 97%, Missing); skeletal muscle: 62.0253% (minimum 99%, Missing); skin: 68.0556% (minimum 95%, Missing); small intestine: 65.3333% (minimum 99%, Missing); smooth muscle: 87.5000% (minimum 99%, Missing); spinal cord: 61.6352% (minimum 99%, Missing); spleen: 64.9007% (minimum 95%, Missing); stomach: 70.5036% (minimum 97%, Missing); thymus: 85.9649% (minimum 95%, Missing); thyroid gland: 64.9007% (minimum 95%, Missing); tongue: 88.2883% (minimum 97%, Missing); urinary bladder: 67.1233% (minimum 97%, Missing)",0,80,unavailable,10.2,4.8,5.3,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); thyroid gland: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 2); pancreas: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 2); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 2); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 2); esophagus: 3.7 nTPM (protected, limit 2); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); rectum: 2.7 nTPM (protected, limit 2); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000276234,TADA2A,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.300993,-0.298767,-0.5
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,False,,9,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,ENSG00000276240,OR4E1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,ENSG00000276240,OR4E1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,ENSG00000276240,OR4E1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,False,,0,4,partial,1,0.2,1,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000276410,H2BC3,reproductive_required,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 56.5217% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 72.2222% (minimum 99%, Baseline (adaptation disabled)); colon: 92.8571% (minimum 97%, Baseline (adaptation disabled)); duodenum: 92.8571% (minimum 99%, Baseline (adaptation disabled)); esophagus: 92.8571% (minimum 97%, Baseline (adaptation disabled)); lymph node: 86.6667% (minimum 97%, Baseline (adaptation disabled)); retina: 92.8571% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 86.6667% (minimum 99%, Baseline (adaptation disabled)); small intestine: 92.8571% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 92.8571% (minimum 99%, Baseline (adaptation disabled)); spleen: 92.8571% (minimum 95%, Baseline (adaptation disabled)); thymus: 56.5217% (minimum 95%, Baseline (adaptation disabled))",0,4,partial,1,0.2,1,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000276410,H2BC3,current_fixed,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.384783,-0.103333,-0.424783
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 56.5217% (minimum 99%, Missing); choroid plexus: 72.2222% (minimum 99%, Missing); colon: 92.8571% (minimum 97%, Missing); duodenum: 92.8571% (minimum 99%, Missing); esophagus: 92.8571% (minimum 97%, Missing); lymph node: 86.6667% (minimum 97%, Missing); retina: 92.8571% (minimum 99%, Missing); skeletal muscle: 86.6667% (minimum 99%, Missing); small intestine: 92.8571% (minimum 99%, Missing); spinal cord: 92.8571% (minimum 99%, Missing); spleen: 92.8571% (minimum 95%, Missing); thymus: 56.5217% (minimum 95%, Missing)",0,4,partial,1,0.2,1,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,ENSG00000276410,H2BC3,current_adaptive,False,False,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.384783,-0.103333,-0.424783
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,1.6,29.3,42.2,"skin: 42.2 nTPM (manageable, limit 5); esophagus: 29.3 nTPM (protected, limit 2); salivary gland: 14.9 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,ENSG00000276430,FAM25C,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 32.7982% (minimum 97%, Baseline (adaptation disabled)); salivary gland: 48.9726% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 98.6207% (minimum 99%, Baseline (adaptation disabled)); skin: 25.3097% (minimum 95%, Baseline (adaptation disabled)); small intestine: 89.9371% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.6,29.3,42.2,"skin: 42.2 nTPM (manageable, limit 5); esophagus: 29.3 nTPM (protected, limit 2); salivary gland: 14.9 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,ENSG00000276430,FAM25C,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.696903,-0.642018,-0.0906289
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 32.7982% (minimum 97%, Missing); salivary gland: 48.9726% (minimum 97%, Missing); skeletal muscle: 98.6207% (minimum 99%, Missing); skin: 25.3097% (minimum 95%, Missing); small intestine: 89.9371% (minimum 99%, Missing)",0,80,unavailable,1.6,29.3,42.2,"skin: 42.2 nTPM (manageable, limit 5); esophagus: 29.3 nTPM (protected, limit 2); salivary gland: 14.9 nTPM (protected, limit 2); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,ENSG00000276430,FAM25C,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,-0.696903,-0.642018,-0.0906289
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276581,SPATA31A5,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276581,SPATA31A5,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276581,SPATA31A5,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276747,PADI6,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276747,PADI6,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276747,PADI6,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276950,GSTT4,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276950,GSTT4,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000276950,GSTT4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000277322,GOLGA6L6,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000277322,GOLGA6L6,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000277322,GOLGA6L6,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,False,,0,0,routine_complete,2.2,2,2.2,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000277462,ZNF670,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 62.1622% (minimum 99%, Baseline (adaptation disabled)); amygdala: 69.6970% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 71.8750% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 82.1429% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 51.1111% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 58.9744% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 79.3103% (minimum 99%, Baseline (adaptation disabled)); colon: 60.5263% (minimum 97%, Baseline (adaptation disabled)); duodenum: 69.6970% (minimum 99%, Baseline (adaptation disabled)); esophagus: 65.7143% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 69.6970% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 71.8750% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 67.6471% (minimum 99%, Baseline (adaptation disabled)); kidney: 57.5000% (minimum 99%, Baseline (adaptation disabled)); liver: 58.9744% (minimum 99%, Baseline (adaptation disabled)); lung: 60.5263% (minimum 99%, Baseline (adaptation disabled)); lymph node: 62.1622% (minimum 97%, Baseline (adaptation disabled)); midbrain: 71.8750% (minimum 99%, Baseline (adaptation disabled)); pancreas: 56.0976% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 60.5263% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 69.6970% (minimum 99%, Baseline (adaptation disabled)); rectum: 63.8889% (minimum 97%, Baseline (adaptation disabled)); retina: 52.2727% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 60.5263% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 71.8750% (minimum 99%, Baseline (adaptation disabled)); skin: 62.1622% (minimum 95%, Baseline (adaptation disabled)); small intestine: 60.5263% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 58.9744% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 69.6970% (minimum 99%, Baseline (adaptation disabled)); spleen: 62.1622% (minimum 95%, Baseline (adaptation disabled)); stomach: 53.4884% (minimum 97%, Baseline (adaptation disabled)); thymus: 56.0976% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 62.1622% (minimum 95%, Baseline (adaptation disabled)); tongue: 62.1622% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 58.9744% (minimum 97%, Baseline (adaptation disabled))",0,0,routine_complete,2.2,2,2.2,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000277462,ZNF670,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.438889,-0.435116,-0.478889
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 95%, Missing); adrenal gland: 62.1622% (minimum 99%, Missing); amygdala: 69.6970% (minimum 99%, Missing); basal ganglia: 71.8750% (minimum 99%, Missing); bone marrow: 82.1429% (minimum 99%, Uncertain); cerebellum: 51.1111% (minimum 99%, Missing); cerebral cortex: 58.9744% (minimum 99%, Missing); choroid plexus: 79.3103% (minimum 99%, Missing); colon: 60.5263% (minimum 97%, Missing); duodenum: 69.6970% (minimum 99%, Missing); esophagus: 65.7143% (minimum 97%, Missing); heart muscle: 69.6970% (minimum 99%, Missing); hippocampal formation: 71.8750% (minimum 99%, Missing); hypothalamus: 67.6471% (minimum 99%, Missing); kidney: 57.5000% (minimum 99%, Missing); liver: 58.9744% (minimum 99%, Uncertain); lung: 60.5263% (minimum 99%, Missing); lymph node: 62.1622% (minimum 97%, Missing); midbrain: 71.8750% (minimum 99%, Missing); pancreas: 56.0976% (minimum 99%, Missing); parathyroid gland: 60.5263% (minimum 97%, Missing); pituitary gland: 69.6970% (minimum 99%, Missing); rectum: 63.8889% (minimum 97%, Missing); retina: 52.2727% (minimum 99%, Missing); salivary gland: 60.5263% (minimum 97%, Missing); skeletal muscle: 71.8750% (minimum 99%, Missing); skin: 62.1622% (minimum 95%, Missing); small intestine: 60.5263% (minimum 99%, Missing); smooth muscle: 58.9744% (minimum 99%, Missing); spinal cord: 69.6970% (minimum 99%, Missing); spleen: 62.1622% (minimum 95%, Missing); stomach: 53.4884% (minimum 97%, Missing); thymus: 56.0976% (minimum 95%, Missing); thyroid gland: 62.1622% (minimum 95%, Missing); tongue: 62.1622% (minimum 97%, Missing); urinary bladder: 58.9744% (minimum 97%, Missing)",0,0,routine_complete,2.2,2,2.2,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,ENSG00000277462,ZNF670,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.438889,-0.435116,-0.478889
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000277535,CT47C1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000277535,CT47C1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,ENSG00000277535,CT47C1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1,0.6,1.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000277745,H2AB3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 96.8254% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.7055% (minimum 99%, Baseline (adaptation disabled)); kidney: 98.3871% (minimum 99%, Baseline (adaptation disabled)); small intestine: 98.0707% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1,0.6,1.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000277745,H2AB3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.00611285,0.0107074,-0.021746
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 96.8254% (minimum 99%, Missing); heart muscle: 98.7055% (minimum 99%, Missing); kidney: 98.3871% (minimum 99%, Missing); small intestine: 98.0707% (minimum 99%, Missing)",0,80,unavailable,1,0.6,1.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,ENSG00000277745,H2AB3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.00611285,0.0107074,-0.021746
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000277865,GOLGA6L22,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebral cortex: 98.7952% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000277865,GOLGA6L22,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.00204819
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebral cortex: 98.7952% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000277865,GOLGA6L22,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.00204819
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000278057,TEX28,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 98.8636% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000278057,TEX28,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0386364,0.03,-0.00136364
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 98.8636% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000278057,TEX28,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.0386364,0.03,-0.00136364
False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,False,,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,ENSG00000278085,CT45A8,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"basal ganglia: 90.9091% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 90.9091% (minimum 99%, Baseline (adaptation disabled))",0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,ENSG00000278085,CT45A8,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,-0.0809091
False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,"basal ganglia: 90.9091% (minimum 99%, Missing); hypothalamus: 90.9091% (minimum 99%, Missing)",0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,ENSG00000278085,CT45A8,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025;da Silva 2017,0.05,0.03,-0.0809091
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,3,partial,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,ENSG00000278289,CT45A6,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 14.2857% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 2.5000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 33.3333% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 20.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 7.6923% (minimum 99%, Baseline (adaptation disabled)); midbrain: 33.3333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 7.6923% (minimum 99%, Baseline (adaptation disabled)); retina: 33.3333% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 20.0000% (minimum 99%, Baseline (adaptation disabled))",0,3,partial,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,ENSG00000278289,CT45A6,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.965
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 14.2857% (minimum 99%, Missing); basal ganglia: 2.5000% (minimum 99%, Missing); cerebral cortex: 33.3333% (minimum 97%, Supported); hippocampal formation: 20.0000% (minimum 99%, Missing); hypothalamus: 7.6923% (minimum 99%, Missing); midbrain: 33.3333% (minimum 99%, Missing); pituitary gland: 7.6923% (minimum 99%, Missing); retina: 33.3333% (minimum 99%, Missing); spinal cord: 20.0000% (minimum 99%, Missing)",0,3,partial,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,ENSG00000278289,CT45A6,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Loriot 2025;da Silva 2017,0.05,0.03,-0.965
False,excluded,rna_above_tissue_ceiling,True,True,False,,0,80,unavailable,4.3,2.6,1.9,"retina: 4.3 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000278318,ZNF229,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 56.7568% (minimum 99%, Baseline (adaptation disabled)); amygdala: 65.6250% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 60.0000% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 95.4545% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 70.0000% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 61.7647% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 60.0000% (minimum 99%, Baseline (adaptation disabled)); colon: 70.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.0000% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 70.0000% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 65.6250% (minimum 99%, Baseline (adaptation disabled)); kidney: 72.4138% (minimum 99%, Baseline (adaptation disabled)); liver: 77.7778% (minimum 99%, Baseline (adaptation disabled)); lung: 80.7692% (minimum 99%, Baseline (adaptation disabled)); lymph node: 87.5000% (minimum 97%, Baseline (adaptation disabled)); midbrain: 65.6250% (minimum 99%, Baseline (adaptation disabled)); pancreas: 75.0000% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 44.6809% (minimum 97%, Baseline (adaptation disabled)); pituitary gland: 63.6364% (minimum 99%, Baseline (adaptation disabled)); rectum: 95.4545% (minimum 97%, Baseline (adaptation disabled)); retina: 32.8125% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 75.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 87.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 87.5000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 72.4138% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 70.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 77.7778% (minimum 95%, Baseline (adaptation disabled)); stomach: 77.7778% (minimum 97%, Baseline (adaptation disabled)); thymus: 65.6250% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 52.5000% (minimum 95%, Baseline (adaptation disabled)); tongue: 65.6250% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",0,80,unavailable,4.3,2.6,1.9,"retina: 4.3 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000278318,ZNF229,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.425,-0.523191,-0.661875
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 80.7692% (minimum 95%, Missing); adrenal gland: 56.7568% (minimum 99%, Missing); amygdala: 65.6250% (minimum 99%, Missing); basal ganglia: 60.0000% (minimum 99%, Missing); bone marrow: 95.4545% (minimum 99%, Missing); cerebellum: 70.0000% (minimum 99%, Missing); cerebral cortex: 61.7647% (minimum 99%, Missing); choroid plexus: 60.0000% (minimum 99%, Missing); colon: 70.0000% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 75.0000% (minimum 97%, Missing); heart muscle: 60.0000% (minimum 99%, Missing); hippocampal formation: 70.0000% (minimum 99%, Missing); hypothalamus: 65.6250% (minimum 99%, Missing); kidney: 72.4138% (minimum 99%, Missing); liver: 77.7778% (minimum 99%, Missing); lung: 80.7692% (minimum 99%, Missing); lymph node: 87.5000% (minimum 97%, Missing); midbrain: 65.6250% (minimum 99%, Missing); pancreas: 75.0000% (minimum 99%, Missing); parathyroid gland: 44.6809% (minimum 97%, Missing); pituitary gland: 63.6364% (minimum 99%, Missing); rectum: 95.4545% (minimum 97%, Missing); retina: 32.8125% (minimum 99%, Missing); salivary gland: 75.0000% (minimum 97%, Missing); skeletal muscle: 75.0000% (minimum 99%, Missing); skin: 87.5000% (minimum 95%, Missing); small intestine: 87.5000% (minimum 99%, Missing); smooth muscle: 72.4138% (minimum 99%, Missing); spinal cord: 70.0000% (minimum 99%, Missing); spleen: 77.7778% (minimum 95%, Missing); stomach: 77.7778% (minimum 97%, Missing); thymus: 65.6250% (minimum 95%, Missing); thyroid gland: 52.5000% (minimum 95%, Missing); tongue: 65.6250% (minimum 97%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",0,80,unavailable,4.3,2.6,1.9,"retina: 4.3 nTPM (vital, limit 1); parathyroid gland: 2.6 nTPM (protected, limit 2); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,ENSG00000278318,ZNF229,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.425,-0.523191,-0.661875
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000278522,POTEB3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 98.0000% (minimum 99%, Baseline (adaptation disabled)); retina: 98.0000% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000278522,POTEB3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0107843,0.03,-0.01
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 98.0000% (minimum 99%, Missing); retina: 98.0000% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,ENSG00000278522,POTEB3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.0107843,0.03,-0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000278685,IQCA1L,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skeletal muscle: 97.7273% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000278685,IQCA1L,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.0127273
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skeletal muscle: 97.7273% (minimum 99%, Missing)",0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000278685,IQCA1L,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021;da Silva 2017,0.05,0.03,-0.0127273
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000279169,PRAMEF13,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000279169,PRAMEF13,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000279169,PRAMEF13,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000279408,OR4N4C,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000279408,OR4N4C,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000279408,OR4N4C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000282419,TEX13D,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000282419,TEX13D,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000282419,TEX13D,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000282815,TEX13C,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,,,
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000282815,TEX13C,current_fixed,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,0.05,0.03,0.01
True,compatible,,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000282815,TEX13C,current_adaptive,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Gong 2021;Carter 2023;Loriot 2025,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,False,,0,80,unavailable,4.7,0,0,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000283093,CENPVL2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 46.6667% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 12.9630% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 53.8462% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 58.3333% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 13.2075% (minimum 99%, Baseline (adaptation disabled)); midbrain: 53.8462% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 77.7778% (minimum 99%, Baseline (adaptation disabled)); spinal cord: 77.7778% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,4.7,0,0,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000283093,CENPVL2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.05,0.03,-0.86037
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence,False,False,True,"amygdala: 46.6667% (minimum 99%, Missing); basal ganglia: 12.9630% (minimum 99%, Missing); cerebral cortex: 53.8462% (minimum 99%, Missing); hippocampal formation: 58.3333% (minimum 99%, Missing); hypothalamus: 13.2075% (minimum 99%, Missing); midbrain: 53.8462% (minimum 99%, Missing); pituitary gland: 77.7778% (minimum 99%, Missing); spinal cord: 77.7778% (minimum 99%, Missing)",0,80,unavailable,4.7,0,0,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,ENSG00000283093,CENPVL2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1371/journal.pgen.1011734,Loriot 2025,0.05,0.03,-0.86037
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000283205,ENSG00000283205,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000283205,ENSG00000283205,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.0130508,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,ENSG00000283205,ENSG00000283205,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.0130508,0.01
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1.1,1.8,0.9,"pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000283268,TEX54,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pituitary gland: 98.5488% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.1,1.8,0.9,"pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000283268,TEX54,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0380952,0.00647059,-0.00451187
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pituitary gland: 98.5488% (minimum 99%, Missing)",0,80,unavailable,1.1,1.8,0.9,"pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,ENSG00000283268,TEX54,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0380952,0.00647059,-0.00451187
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283434,CSNK2A2IP,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283434,CSNK2A2IP,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283434,CSNK2A2IP,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283439,SPEM3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283439,SPEM3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283439,SPEM3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,2.7,0.1,0.2,"adrenal gland: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000283463,HSFX4,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 84.3931% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 98.6486% (minimum 99%, Baseline (adaptation disabled)); liver: 98.6486% (minimum 99%, Baseline (adaptation disabled)); pancreas: 98.6486% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.6486% (minimum 99%, Baseline (adaptation disabled)); retina: 98.6486% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,2.7,0.1,0.2,"adrenal gland: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000283463,HSFX4,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0364865,0.0231973,-0.146069
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 84.3931% (minimum 99%, Missing); heart muscle: 98.6486% (minimum 99%, Missing); liver: 98.6486% (minimum 99%, Missing); pancreas: 98.6486% (minimum 99%, Missing); pituitary gland: 98.6486% (minimum 99%, Missing); retina: 98.6486% (minimum 99%, Missing)",0,80,unavailable,2.7,0.1,0.2,"adrenal gland: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,ENSG00000283463,HSFX4,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.0364865,0.0231973,-0.146069
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000283516,LITAFD,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 95.8333% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 97.1831% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000283516,LITAFD,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.0316667
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 95.8333% (minimum 99%, Missing); pituitary gland: 97.1831% (minimum 99%, Missing)",0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,ENSG00000283516,LITAFD,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,-0.0316667
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283594,FAM236C,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283594,FAM236C,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283594,FAM236C,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,,True,True,False,,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000283599,ENSG00000283599,reproductive_required,True,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Gong 2021;Carter 2023,,,
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.7654% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 97.5610% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.7654% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000283599,ENSG00000283599,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Gong 2021;Carter 2023,0.05,0.03,-0.0143902
False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 98.7654% (minimum 99%, Missing); cerebral cortex: 97.5610% (minimum 99%, Missing); choroid plexus: 98.7654% (minimum 99%, Missing)",0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,ENSG00000283599,ENSG00000283599,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Gong 2021;Carter 2023,0.05,0.03,-0.0143902
False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,1.2,0,0.3,"adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000283697,HSFX3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 92.1053% (minimum 99%, Baseline (adaptation disabled)); heart muscle: 97.9021% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.5915% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,1.2,0,0.3,"adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000283697,HSFX3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.029021,0.03,-0.0689474
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 92.1053% (minimum 99%, Missing); heart muscle: 97.9021% (minimum 99%, Missing); pituitary gland: 98.5915% (minimum 99%, Missing)",0,80,unavailable,1.2,0,0.3,"adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,ENSG00000283697,HSFX3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.029021,0.03,-0.0689474
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,False,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283758,PMIS2,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283758,PMIS2,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;existing_nomination_or_manual_review,False,False,True,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000283758,PMIS2,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.03,0.01
True,compatible,existing_nomination_or_manual_review,True,True,False,,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,ENSG00000284188,C1orf202,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,,,
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 98.8506% (minimum 99%, Baseline (adaptation disabled)); basal ganglia: 96.6292% (minimum 99%, Baseline (adaptation disabled)); cerebellum: 98.8506% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 98.8506% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 98.8506% (minimum 99%, Baseline (adaptation disabled)); hippocampal formation: 98.8506% (minimum 99%, Baseline (adaptation disabled)); hypothalamus: 98.8506% (minimum 99%, Baseline (adaptation disabled)); midbrain: 98.8506% (minimum 99%, Baseline (adaptation disabled)); pituitary gland: 98.8506% (minimum 99%, Baseline (adaptation disabled)); skeletal muscle: 96.6292% (minimum 99%, Baseline (adaptation disabled))",0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,ENSG00000284188,C1orf202,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.0185057,-0.0237079
False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 98.8506% (minimum 99%, Missing); basal ganglia: 96.6292% (minimum 99%, Missing); cerebellum: 98.8506% (minimum 99%, Missing); cerebral cortex: 98.8506% (minimum 99%, Missing); choroid plexus: 98.8506% (minimum 99%, Missing); hippocampal formation: 98.8506% (minimum 99%, Missing); hypothalamus: 98.8506% (minimum 99%, Missing); midbrain: 98.8506% (minimum 99%, Missing); pituitary gland: 98.8506% (minimum 99%, Missing); skeletal muscle: 96.6292% (minimum 99%, Missing)",0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,ENSG00000284188,C1orf202,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.1038/s41467-021-22695-y,Gong 2021,0.05,0.0185057,-0.0237079
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000284609,OR8B3,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000284609,OR8B3,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000284609,OR8B3,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna,True,True,False,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000284680,OR8B2,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,,,
False,unresolved,incomplete_routine_rna,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000284680,OR8B2,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna,True,True,True,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,ENSG00000284680,OR8B2,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Wang 2016;Gong 2021;da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,False,,9,4,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000284701,TMEM247,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,9,4,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000284701,TMEM247,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,9,4,partial,0,0,0,,,50,not_established,not_triggered,,,ENSG00000284701,TMEM247,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,0.05,0.03,0.01
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,False,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000284723,OR8S1,reproductive_required,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000284723,OR8S1,current_fixed,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,ENSG00000284723,OR8S1,current_adaptive,False,True,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,10.18632/oncotarget.21715,da Silva 2017,,,
False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,False,,9,5,partial,8.4,3.8,6.6,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); kidney: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil,ENSG00000284770,TBCE,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5424% (minimum 95%, Baseline (adaptation disabled)); adrenal gland: 42.4658% (minimum 99%, Baseline (adaptation disabled)); bone marrow: 58.4906% (minimum 99%, Baseline (adaptation disabled)); cerebral cortex: 63.2653% (minimum 99%, Baseline (adaptation disabled)); choroid plexus: 58.4906% (minimum 99%, Baseline (adaptation disabled)); colon: 44.9275% (minimum 97%, Baseline (adaptation disabled)); duodenum: 54.3860% (minimum 99%, Baseline (adaptation disabled)); esophagus: 47.6923% (minimum 97%, Baseline (adaptation disabled)); heart muscle: 38.7500% (minimum 99%, Baseline (adaptation disabled)); kidney: 46.9697% (minimum 99%, Baseline (adaptation disabled)); liver: 36.4706% (minimum 99%, Baseline (adaptation disabled)); lung: 62.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 59.6154% (minimum 97%, Baseline (adaptation disabled)); pancreas: 63.2653% (minimum 99%, Baseline (adaptation disabled)); parathyroid gland: 51.6667% (minimum 97%, Baseline (adaptation disabled)); rectum: 50.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 41.3333% (minimum 99%, Baseline (adaptation disabled)); salivary gland: 47.6923% (minimum 97%, Baseline (adaptation disabled)); skeletal muscle: 26.9565% (minimum 99%, Baseline (adaptation disabled)); skin: 59.6154% (minimum 95%, Baseline (adaptation disabled)); small intestine: 70.4545% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 62.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 60.7843% (minimum 95%, Baseline (adaptation disabled)); stomach: 45.5882% (minimum 97%, Baseline (adaptation disabled)); thymus: 60.7843% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 31.9588% (minimum 95%, Baseline (adaptation disabled)); tongue: 67.3913% (minimum 97%, Baseline (adaptation disabled)); urinary bladder: 55.3571% (minimum 97%, Baseline (adaptation disabled))",9,5,partial,8.4,3.8,6.6,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); kidney: 3.5 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 2); salivary gland: 3.4 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lymph node: 2.1 nTPM (protected, limit 2); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil,ENSG00000284770,TBCE,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.630412,-0.520725,-0.720435
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5424% (minimum 95%, Missing); adrenal gland: 42.4658% (minimum 99%, Missing); bone marrow: 58.4906% (minimum 99%, Missing); cerebral cortex: 63.2653% (minimum 99%, Missing); choroid plexus: 58.4906% (minimum 99%, Missing); colon: 44.9275% (minimum 97%, Missing); duodenum: 54.3860% (minimum 99%, Missing); esophagus: 47.6923% (minimum 97%, Missing); heart muscle: 38.7500% (minimum 99%, Missing); kidney: 46.9697% (minimum 99%, Missing); liver: 36.4706% (minimum 99%, Missing); lung: 62.0000% (minimum 98%, Approved); lymph node: 59.6154% (minimum 95%, Approved); pancreas: 63.2653% (minimum 99%, Missing); parathyroid gland: 51.6667% (minimum 97%, Missing); rectum: 50.0000% (minimum 97%, Missing); retina: 41.3333% (minimum 99%, Missing); salivary gland: 47.6923% (minimum 97%, Missing); skeletal muscle: 26.9565% (minimum 99%, Missing); skin: 59.6154% (minimum 95%, Missing); small intestine: 70.4545% (minimum 99%, Missing); smooth muscle: 62.0000% (minimum 98%, Approved); spleen: 60.7843% (minimum 95%, Missing); stomach: 45.5882% (minimum 97%, Missing); thymus: 60.7843% (minimum 95%, Missing); thyroid gland: 31.9588% (minimum 95%, Missing); tongue: 67.3913% (minimum 97%, Missing); urinary bladder: 55.3571% (minimum 97%, Missing)",9,5,partial,8.4,3.8,6.6,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 2); stomach: 3.7 nTPM (protected, limit 2); kidney: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 2); esophagus: 3.4 nTPM (protected, limit 2); rectum: 3.1 nTPM (protected, limit 2); parathyroid gland: 2.9 nTPM (protected, limit 2); duodenum: 2.6 nTPM (vital, limit 1); urinary bladder: 2.5 nTPM (protected, limit 2); bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil,ENSG00000284770,TBCE,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1002/1878-0261.12900,Jamin 2021,-0.630412,-0.520725,-0.720435
False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,False,,9,80,unavailable,5,1.4,1.4,"bone marrow: 5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000285077,ARHGAP11B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,True,"adipose tissue: 60.0000% (minimum 95%, Baseline (adaptation disabled)); bone marrow: 5.6604% (minimum 99%, Baseline (adaptation disabled)); colon: 60.0000% (minimum 97%, Baseline (adaptation disabled)); duodenum: 75.0000% (minimum 99%, Baseline (adaptation disabled)); esophagus: 75.0000% (minimum 97%, Baseline (adaptation disabled)); liver: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lung: 75.0000% (minimum 99%, Baseline (adaptation disabled)); lymph node: 17.6471% (minimum 97%, Baseline (adaptation disabled)); parathyroid gland: 75.0000% (minimum 97%, Baseline (adaptation disabled)); rectum: 50.0000% (minimum 97%, Baseline (adaptation disabled)); retina: 75.0000% (minimum 99%, Baseline (adaptation disabled)); skin: 37.5000% (minimum 95%, Baseline (adaptation disabled)); small intestine: 50.0000% (minimum 99%, Baseline (adaptation disabled)); smooth muscle: 60.0000% (minimum 99%, Baseline (adaptation disabled)); spleen: 50.0000% (minimum 95%, Baseline (adaptation disabled)); stomach: 42.8571% (minimum 97%, Baseline (adaptation disabled)); thymus: 17.6471% (minimum 95%, Baseline (adaptation disabled)); thyroid gland: 75.0000% (minimum 95%, Baseline (adaptation disabled)); urinary bladder: 75.0000% (minimum 97%, Baseline (adaptation disabled))",9,80,unavailable,5,1.4,1.4,"bone marrow: 5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000285077,ARHGAP11B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.773529,-0.793529,-0.933396
False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,True,"adipose tissue: 60.0000% (minimum 95%, Missing); bone marrow: 5.6604% (minimum 99%, Missing); colon: 60.0000% (minimum 97%, Missing); duodenum: 75.0000% (minimum 99%, Missing); esophagus: 75.0000% (minimum 97%, Missing); liver: 75.0000% (minimum 99%, Missing); lung: 75.0000% (minimum 99%, Missing); lymph node: 17.6471% (minimum 97%, Missing); parathyroid gland: 75.0000% (minimum 97%, Missing); rectum: 50.0000% (minimum 97%, Missing); retina: 75.0000% (minimum 99%, Missing); skin: 37.5000% (minimum 95%, Missing); small intestine: 50.0000% (minimum 99%, Missing); smooth muscle: 60.0000% (minimum 99%, Missing); spleen: 50.0000% (minimum 95%, Missing); stomach: 42.8571% (minimum 97%, Missing); thymus: 17.6471% (minimum 95%, Missing); thyroid gland: 75.0000% (minimum 95%, Missing); urinary bladder: 75.0000% (minimum 97%, Missing)",9,80,unavailable,5,1.4,1.4,"bone marrow: 5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,ENSG00000285077,ARHGAP11B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,-0.773529,-0.793529,-0.933396
False,excluded,insufficient_positive_reproductive_evidence;incomplete_routine_rna,False,False,False,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000293137,MSL3B,reproductive_required,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000293137,MSL3B,current_fixed,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,
False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,ENSG00000293137,MSL3B,current_adaptive,False,True,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,10.1038/s41388-018-0357-2,Bruggeman 2018,,,